%0 Journal Article %T Hp感染对冠心病患者抗血小板治疗效果及远期预后的影响 %T Effect of Hp infection on anti-platelet therapy and long-term prognosis in patients with coronary heart disease %A 张士铭 %A ZHANG,Shi ming %J 中国临床新医学 %J CHINESE JOURNAL OF NEW CLINICAL MEDICINE %@ 1674-3806 %V 10 %N 12 %D 2017 %P 1207-1210 %K 冠心病;抗血小板治疗;幽门螺杆菌 %K Coronary heart disease(CHD);Anti-platelet therapy;Helicobacter pylori %X [摘要] 目的 研究幽门螺杆菌(Hp)感染对冠心病患者抗血小板治疗效果及远期预后的影响。方法 选取该院2012-05~2015-05收治的97例冠心病患者为研究对象,所有患者接受抗血小板治疗,根据Hp感染情况将患者分为感染组(n=62)与未感染组(n=35)。分析两组抗血小板效果、血脂水平以及1年内预后。结果 感染组治疗后的纤维蛋白原、总胆固醇、消化道出血率、心血管事件发生率分别为(5.21±1.57)g/L、(5.36±1.17)mmol/L、21.0%、29.0%,显著高于未感染组的(3.32±1.19)g/L、(4.24±1.35)mmol/L、5.7%、11.4%(P<0.05)。结论 幽门螺杆菌感染可能对冠心病抗血小板治疗效果产生影响,诱发心血管事件,增加消化道出血风险,不利于患者的远期预后。 %X [Abstract] Objective To study the effect of Hp infection on anti-platelet therapy and long-term prognosis in patients with coronary heart disease(CHD).Methods From May 2012 to May 2015, 97 patients with CHD in our hospital were given anti-platelet therapy and they were divided into the infection group(n=62) and the non-infection group(n=35). The effects of anti-platelet therapy, the levels of blood lipid and the prognosis were analyzed within 1 year of the therapy.Results After the treatment, the levels of fibrinogen and total cholesterol, the incidence rates of digestive tract hemorrhage and cardiovascular events in the infection group[(5.21±1.57)g/L, (5.36±1.17)mmol/L,21.0%, 29.0%] were significantly higher than those in the non-infection group[(3.32±1.19)g/L, (4.24±1.35)mmol/L, 5.7%, 11.4%](P<0.05).Conclusion Helicobacter pylori infection may have adverse effects on the anti-platelet therapy in the patients with CHD, which induce cardiovascular events and increase the risk of gastrointestinal bleeding and which is unfavorable for the long-term prognosis. %R 10.3969/j.issn.1674-3806.2017.12.25 %U http://www.zglcxyxzz.com/ch/reader/view_abstract.aspx %1 JIS Version 3.0.0