引用本文:严发忠,谭 萍,崔德志,高永盛,秦宁恩加,李禄庆.帕瑞昔布钠联合地佐辛超前镇痛对老年胃癌术后认知功能及炎症因子的影响[J].中国临床新医学,2017,10(8):765-768.
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帕瑞昔布钠联合地佐辛超前镇痛对老年胃癌术后认知功能及炎症因子的影响
严发忠,谭 萍,崔德志,高永盛,秦宁恩加,李禄庆
733299 甘肃,天祝县人民医院普外科(严发忠,崔德志,高永盛,秦宁恩加,李禄庆);730050 兰州,甘肃省中医院麻醉手术科(谭 萍)
摘要:
[摘要] 目的 探讨帕瑞昔布钠联合地佐辛超前镇痛对老年胃癌术后认知功能及炎症因子的影响。方法 选取2012-03~2014-05在该院行胃癌手术的72例老年患者,采用奇偶法将其分为观察组和对照组,各36例。对照组给予常规麻醉,观察组给予帕瑞昔布钠联合地佐辛静脉注射。观察比较两组患者不同时点的镇痛情况、炎症因子水平、认知功能以及不良反应发生情况。结果 不同检测时间、不同治疗组间的VAS评分之间差异均有统计学意义(P<0.05),检测时间和不同麻醉方式之间存在交互作用(F=5.652,P=0.008);两组患者白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)术前比较差异无统计学意义(P>0.05),手术后两组均显著升高(P<0.05),且观察组明显低于对照组(P<0.01);两组患者术前认知功能比较差异无统计学意义(P>0.05),手术后两组均有所降低,但观察组认知功能改善情况优于对照组,且前者认知功能障碍发生率为25.00%,明显低于后者的47.22%(P<0.05);观察组不良反应的总发生率为30.56%,明显低于对照组,两组患者不良反应的总发生率比较差异有统计学意义(χ2=6.769,P=0.009)。结论 帕瑞昔布钠联合地佐辛超前镇痛应用于老年胃癌手术中,不仅可以明显降低炎症因子反应,而且能够显著改善术后认知功能情况。
关键词:  帕瑞昔布钠  地佐辛  胃癌  认知功能  炎症因子
DOI:10.3969/j.issn.1674-3806.2017.08.15
分类号:R 735
基金项目:
Effects of parecoxib sodium combined with dezocine preemptive analgesia on cognitive function and inflammatory factors in elderly patients with gastric cancer after operation
YAN Fa-zhong, TAN Ping, CUI De-zhi, et al.
Effects of parecoxib sodium combined with dezocine preemptive analgesia on cognitive function and inflammatory factors in elderly patients with gastric cancer after operation
Abstract:
[Abstract] Objective To explore the effects of parecoxib sodium combined with dezocine preemptive analgesia on cognitive function and inflammatory factors in elderly patients with gastric cancer after operation.Methods 72 elderly patients with gastric cancer treated with operation in our hospital from March 2012 to May 2014 were selected as the research subjects and were divided into the observation group and the control group according to the parity method, with 36 cases in each group. The control group was treated with general anesthesia,and the observation group received parecoxib sodium combined with dezocine intravenous injection. The analgesic effects at different time points, the levels of inflammatory factors, the cognitive function and the occurrence of adverse reactions were observed and compared between the two groups.Results There were significant differences in VAS scores between the two groups at different detection time points between the different treatment groups(P<0.05), and there was an interaction between the detection time points and the different anesthetic methods(F=5.652, P=0.008).There were no significant differences in the levels of IL-6, IL-8 and TNF-α before operation between the two groups(P>0.05), and the levels of IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group after operation(P<0.01). There was no significant difference in preoperative cognitive function between the two groups(P>0.05), but the cognitive function of the observation group was better than that of the control group, and the incidence of cognitive dysfunction in the observation group(25.00%) was significantly lower than that in the control group(47.22%)(P<0.05). There was a statistically significant difference in the total incidence of adverse reactions between the two groups(χ2=6.769, P=0.009), and it was 30.56% in the observation group, with a significantly lower rate than that in the control group.Conclusion Parecoxib sodium combined with dezocine analgesia can not only significantly reduce the inflammatory response, but also improve the postoperative cognitive function in the elderly patients with gastric cancer surgery.
Key words:  Parecoxib sodium  Dezocine  Gastric cancer  Cognitive function  Inflammatory factors