引用本文:王瑞锋,尹 娟.同型半胱氨酸与肝炎严重程度的相关性研究[J].中国临床新医学,2017,10(8):794-797.
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同型半胱氨酸与肝炎严重程度的相关性研究
王瑞锋,尹 娟
467000 河南,平煤神马医疗集团总医院检验科
摘要:
[摘要] 目的 探讨同型半胱氨酸与肝炎严重程度间的相关性。方法 以2013-01~2016-10该院收治的112例慢性乙型肝炎患者为研究对象,其中轻度肝炎21例,中度肝炎72例,重度肝炎19例;取同期健康体检者30名作为正常组。检测两组血清生物化学指标丙氨酸转氨酶(ALT)、门冬氨酸转氨酶(AST)、总胆红素(TBIL)、胆碱酯酶(CHE)及同型半胱氨酸(Hcy)浓度。比较两组间及患者组不同病情程度组间上述各指标的血清水平差异,并对患者组内生化指标与Hcy的相关性进行分析。结果 患者组的血清Hcy水平高于正常组,差异具有统计学意义(P<0.05)。轻度、中度、重度患者组的平均血清Hcy水平分别为(9.54±2.63)、(23.41±4.62)与(35.25±63.41)μmol/L,三组差异有统计学意义(P<0.05),轻度组<中度组<重度组(P<0.05)。两组间各生化指标比较差异有统计学意义(P<0.05),患者组血清ALT、AST、TBIL水平高于正常组,CHE水平则低于正常组。ALT、AST、TBIL与Hcy呈正相关,CHE与Hcy呈负相关(P<0.05)。结论 乙型肝炎患者机体Hcy水平变化反映了肝脏的受损情况,可将Hcy持续升高视为肝炎进展的危险因素,为临床诊断、治疗和预后判断提供帮助。
关键词:  同型半胱氨酸  肝炎  相关性
DOI:10.3969/j.issn.1674-3806.2017.08.25
分类号:R 575.1
基金项目:
Study on the correlation between homocysteine and severity of hepatitis
WANG Rui-feng, YIN Juan
Study on the correlation between homocysteine and severity of hepatitis
Abstract:
[Abstract] Objective To investigate the correlation between homocysteine and severity of Hepatitis.Methods 112 patients with chronic hepatitis B admitted to our hospital from January 2013 to October 2016 were taken as the study subjects(the observation group). At the same time, 30 healthy people who came to our hospital for physical examination were taken as the normal controls(the normal group). The serum levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), cholinesterase(CHE) and homocysteine(Hcy) were detected and were compared between the two groups and among the different subgroups in the patients with different degrees of chronic hepatitis B. The correlation between the levels of ALT, AST, TBIL and CHE and the level of Hcy in the observation group was analyzed.Results The average serum level of Hcy in the observation group was significantly higher than that in the normal group(P<0.05). The average serum levels of Hcy in the subgroups of mild, moderate and severe patients were (9.54±2.63), (23.41±4.62) and (35.25±63.41)mol/L respectively, and there was significant difference among the three subgroups(mild groupP<0.05). The serum levels of ALT, AST and TBIL were higher, while the level of CHE was lower in the observation group than those in the normal group. ALT, AST and TBIL were positively correlated with CHE. CHE was negatively correlated with Hcy(P<0.05).Conclusion There is a correlation between the changes of Hcy and severity of hepatitis B. The continuous rising of Hcy is a risk factor for progression of hepatitis.
Key words:  Homocysteine(Hcy)  Hepatitis  Correlation