| 摘要: |
| ［摘要］ 目的 观察右美托咪定用于腰硬联合麻醉下剖宫产手术的疗效。方法 将美国麻醉医师协会（ASA）Ⅰ～Ⅱ级腰硬联合麻醉下行剖宫产手术的产妇100例，按照术中是否使用右美托咪定分为右美托咪定组和对照组，每组50例。右美托咪定组产妇在术中切断脐带后给予右美托咪定，负荷量为0.5 μg/kg快速输注（2～3 min），并以1 μg/（kg·h）术中微泵维持，术毕停用右美托咪定。两组产妇的观察指标包括麻醉前的收缩压（P1）和心率(HR1)、胎儿娩出时的收缩压(P2)、术中最低的收缩压(P3)和术中最快的心率(HR2)；麻黄素总的使用量；牵拉痛、恶心呕吐、寒战等并发症；麻醉医师及产妇的麻醉满意度；术中呼吸抑制及术后过度镇静等不良反应的发生率。结果 两组产妇P1和HR1比较差异无统计学意义（P>0.05）；P2、P3、HR2及麻黄素总的使用量差异均有统计学意义（P<0.01）；两组产妇术中牵拉痛、恶心呕吐、寒战等并发症及麻醉医师、产妇的麻醉满意度比较差异均有统计学意义（P<0.01）；两组产妇术中呼吸抑制、过度镇静等不良反应发生率差异无统计学意义（P>0.05）。结论 右美托咪定是腰硬联合麻醉下剖宫产手术的一种高效、安全、舒适的麻醉辅助药。 |
| 关键词: 右美托咪定 腰硬联合麻醉 剖宫产 |
| DOI：10.3969/j.issn.1674-3806.2017.09.12 |
| 分类号:R 971.2 |
| 基金项目:广西卫计委科研课题（编号：Z20170074） |
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| Effects of dexmedetomidine on combined spinal and epidural anesthesia in parturient women undergoing cesarean section |
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DENG Zhe
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Department of Anesthesiology, the People′s Hospital of Beihai City, Guangxi 536000, China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of dexmedetomidine on the combined spinal and epidural anesthesia in the parturients undergoing cesarean section.Methods A total of 100 parturient women with ASA Ⅰ or Ⅱ were randomly divided into the dexmedetomidine group and the control group, 50 cases in each group. Dexmedetomidine was rapidly infused intravenously within 2 to 3 minutes at the loading dose of 0.5 μg/kg after umbilical cord was cut, and was maintained at the rate of 1 μg/（kg·h） until the end of surgery. The paramenter women including systolic blood pressure（P1） and heart rate(HR1) at preanesthesia, the systolic blood pressure after childbirth（P2）, the lowest systolic blood pressure(P3) and the fastest heart rate(HR2) during operation, the total amount of ephedrine, the complications of dragging pain, nausea and vomiting, shiver, anesthesia satisfactions from anesthesiologists and parturient women, and the incidences of adverse reactions of intraoperative respiratory depression and excessive postoperative sedation were compared between the two groups.Results There were no significant differences in P1 and HR1（P>0.05） and there were significant differences in P2, P3, HR2 and the total amount of ephedrine between the two groups（P<0.01）; There were significant differences in the dragging pain, nausea and vomiting, shiver; anesthesia satisfactions from the anesthesiologists and parturient women（P<0.01）, and there were no significant differences in the incidences of adverse reactions of intraoperative respiratory depression and excessive postoperative sedation between the two groups（P>0.05）.Conclusion Dexmedetomidine is a safe, effective and comfortable auxiliary anesthetic agent for the the combined spinal and epidural anesthesia in the parturient women undergoing cesarean section. |
| Key words: Dexmedetomidine Combined spinal and epidural anesthesia Cesarean section |
