| 摘要: |
| ［摘要］ 目的 探讨前列地尔联合厄贝沙坦治疗对早期糖尿病肾病患者血流变学及肾功能的影响。方法 选择2015-06～2016-06该院收治的80例早期糖尿病肾病患者作为研究对象，采用随机数字表法将其分为观察组和对照组，每组40例。对照组服用厄贝沙坦治疗，观察组采用前列地尔联合厄贝沙坦治疗，2周一疗程，均服用2个疗程。比较两组患者的治疗效果及治疗前后的血流变学及肾功能等指标水平。结果 治疗前两组血流变学指标相比，差异无统计学意义（P>0.05），治疗后观察组血流变学指标改善情况明显优于对照组，差异有统计学意义（P<0.01）；治疗前两组肾功能指标相比，差异无统计学意义（P>0.05），治疗后观察组血肌酐（Scr）、尿素氮（BUN）及尿蛋白排泄率（UAER）水平均显著低于对照组，而血清白蛋白（Alb）水平高于对照组，差异有统计学意义（P<0.01）。观察组临床疗效优于对照组，差异有统计学意义（P<0.01）。结论 早期糖尿病肾病患者采用前列地尔联合厄贝沙坦治疗效果显著，可明显改善患者肾功能及血流变学，缓解临床症状，值得临床广泛应用。 |
| 关键词: 前列地尔 厄贝沙坦 糖尿病肾病 肾功能 |
| DOI：10.3969/j.issn.1674-3806.2017.09.17 |
| 分类号:R 587.1 |
| 基金项目: |
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| Effect of alprostadil combined with irbesartan on the treatment of early diabetic nephropathy and blood rheology and renal function |
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LIU Xin-sheng
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Department of Endocrinology, the People′s Hospital of Changyuan County, Henan 453400, China
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| Abstract: |
| ［Abstract］ Objective To investigate the effect of alprostadil combined with irbesartan on the treatment of early diabetic nephropathy and blood rheology and renal function.Methods 80 patients with diabetic nephropathy in our hospital during June 2015 to June 2016 were collected as the research subjects, and were randomly divided into the observation group and the control group, with 40 cases in each group. The control group was given irbesartan, and the observation group was treated with alprostadil combined with irbesartan for 4 weeks. The therapeutic effects and the changes of blood flow and renal function and other indexes were compared between the two groups.Results There were no significant differences in the levels of blood flow and renal function between the two groups（P>0.05）. The blood rheology indicators of the observation group improved significantly better than those of the control group(P<0.01). The levels of Scr, BUN and UAER in the observation group were significantly lower than those in the control group, while the level of Alb in the observation group was higher than that in the control group(P<0.01). The total effective rate of the observation group was higher than that of the control group(P<0.01).Conclusion Alprostadil combined with irbesartan can effectively improve the renal function and blood rheology, and relieve the symptoms in the patients with early diabetic nephropathy. |
| Key words: Alprostadil Irbesartan Diabetic nephropathy Renal function |
