摘要: |
[摘要] 放射治疗是肿瘤综合治疗的重要手段,在其应用日趋广泛的同时,放疗抵抗问题也日趋凸显,放疗敏感性不高成为影响肿瘤患者放疗疗效的关键问题。环氧合酶-2已被证实参与肿瘤的发生发展,近期研究证实其表达能导致放疗抵抗。该文将对环氧合酶-2的表达在放疗抵抗的产生中的作用及其机制进行综述。 |
关键词: 环氧合酶-2 放射治疗 抵抗 肿瘤 |
DOI:10.3969/j.issn.1674-3806.2017.11.30 |
分类号:R 45 |
基金项目:云南省卫生科技计划项目(编号:2014NS036,2017NS182);云南省教育厅科学研究基金项目(编号:2016ZDX061) |
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The effects and mechanisms of the expression of cyclooxygenase-2 in the production of radiation resistance |
LIU Shan, ZHAO Li, SHEN Hong-mei
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Yunnan Provincial Integrated Chinese and Western Medicine Tumor Research Center(Department of Integrated Chinese and Western Medicine, the Third Affiliated Hospital of Kunming Medical University), Kunming 650118, China
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Abstract: |
[Abstract] Radiation therapy is an important method for the comprehensive treatment of tumors, however resistance has been becoming an increasingly prominent problem, because radiation therapy is applied more and more extensively in clinics. Low radiation sensitivity is a main problem affecting the efficacy of radiotherapy for cancer patients. Cyclooxygenase-2 has been confirmed to participate in the occurrence and development of tumors. Recent studies indicat that the expression of cyclooxygenase-2 can lead to radiation resistance. The effects and mechanisms of the expression of cyclooxygenase-2 in the production of radiation resistance is reviewed in this paper. |
Key words: Cyclooxygenase-2 Radiation therapy Resistance Tumors |