引用本文:张 梅,冯 良.益肾活血汤对子宫内膜异位症合并不孕症患者腹腔镜术后氧化应激因子及激素水平的影响[J].中国临床新医学,2017,10(12):1185-1188.
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益肾活血汤对子宫内膜异位症合并不孕症患者腹腔镜术后氧化应激因子及激素水平的影响
张 梅,冯 良
450012 河南,郑州市妇幼保健院药剂科
摘要:
[摘要] 目的 探讨益肾活血汤对子宫内膜异位症合并不孕症患者腹腔镜术后氧化应激因子及激素水平的影响。方法 选取2015-01~2015-12该院收治的70例子宫内膜异位症合并不孕症患者为研究对象,采用随机数字表法分为观察组和对照组各35例。两组患者均行腹腔镜手术治疗,对照组术后给予促性腺激素释放激素激动剂(GnRH-a)皮下注射,观察组给予中药益肾活血汤煎服,两组疗程均为3个月。比较两组氧化应激因子、激素水平等指标。结果 治疗3个月后,观察组患者血清超氧化物岐化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)含量均明显高于对照组(P<0.05),丙二醛(MDA)含量明显低于对照组(P<0.05);血清促卵泡生成素(FSH)、黄体生成素(LH)、雌激素(E2)含量均明显高于对照组(P<0.05)。结论 益肾活血汤有助于降低子宫内膜异位症合并不孕症患者腹腔镜术后氧化应激反应,改善激素水平。
关键词:  子宫内膜异位症  腹腔镜手术  益肾活血汤  氧化应激  激素
DOI:10.3969/j.issn.1674-3806.2017.12.17
分类号:R 453.9
基金项目:
Effects of Yishenhuoxue decoction on oxidative stress and hormone levels in patients with endometriosis complicated with infertility after gynecological laparoscopy
ZHANG Mei, FENG Liang
Department of Pharmacy, Maternal and Child Care Hospital of Zhengzhou City, Henan 450012, China
Abstract:
[Abstract] Objective To explore the effects of Yishenhuoxue decoction on oxidative stress and hormone levels in patients with endometriosis complicated with infertility after gynecological laparoscopy.Methods Seventy patients with endometriosis complicated with infertility were collected as the research subjects in our hospital from January 2015 to December 2015 and were randomly divided into the observation group(treated with Yishenhuoxue decoction, n=35) and the control group (treated with GnRH-a subcutaneous injection, n=35). The levels of oxidative stress and hormones were observed and recorded.Results The levels of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px), follicle-stimulating hormone(FSH), luteinizing hormone(LH) and estradiol(E2) in the observation group were significantly higher than those in the control group(P<0.05). The malondialdehyde(MDA) content of the observation group was significantly lower than that of the control group(P<0.05).Conclusion Yishenhuoxue decoction reduces the oxidative stress response and improves the levels of hormones in the patients with endometriosis complicated with infertility after gynecological laparoscopy.
Key words:  Endometriosis  Gynecological laparoscopy  Yishenhuoxue decoction  Oxidative stress response  Hormones