引用本文:张 诺.七叶皂苷钠对结核性脑膜炎患者脑脊液中细胞数和蛋白质及颅内压的影响[J].中国临床新医学,2017,10(12):1199-1201.
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七叶皂苷钠对结核性脑膜炎患者脑脊液中细胞数和蛋白质及颅内压的影响
张 诺
457000 河南,濮阳市第五人民医院结核内科
摘要:
[摘要] 目的 探讨七叶皂苷钠对结核性脑膜炎患者脑脊液中细胞数和蛋白质及颅内压的影响。方法 将2010-04~2016-09该院接诊的结核性脑膜炎患者104例纳入研究,根据抽签法分为观察组和对照组各52例。在抗结核治疗的基础上,对照组予以地塞米松联合尿激酶治疗,观察组在对照组基础上加用七叶皂苷钠,均需连续治疗8周。比较两组临床疗效、脑脊液细胞数、蛋白质及颅内压情况。结果 观察组显效21例,有效28例,无效3例。对照组显效13例,有效28例,无效11例,观察组疗效高于对照组(P<0.05)。观察组的脑脊液细胞数、蛋白质及颅内压均低于对照组,差异有统计学意义(P<0.05)。结论 对结核性脑膜炎患者在常规治疗的基础上加用七叶皂苷钠治疗,效果确切,有利于降低患者的脑脊液细胞数、蛋白质及颅内压。
关键词:  七叶皂苷钠  结核性脑膜炎  脑脊液细胞数  蛋白质  颅内压
DOI:10.3969/j.issn.1674-3806.2017.12.22
分类号:R 56
基金项目:
Effects of sodium aescinate on cell count, protein content and intracranial pressure in cerebrospinal fluid of patients with tuberculous meningitis
ZHANG Nuo
Department of Internal Medicine -Tuberculosis, the Fifth People′s Hospital of Puyang City, Henan 457000, China
Abstract:
[Abstract] Objective To investigate the effects of sodium aescinate on cell count, protein content and intracranial pressure in cerebrospinal fluid of patients with tuberculous meningitis.Methods From April 2010 to September 2016,104 patients with tuberculous meningitis in our hospital were included in the study, and they were divided into two groups by drawing lots, with 52 cases in each group. The control group received anti-tuberculosis treatment plus dexamethasone and urokinase, while the observation group received the same treatment as the control group plus sodium aescinate. Both of the two groups were treated for 8 weeks. The clinical efficacy, cerebrospinal fluid cell count, protein content and intracranial pressure were compared between the two groups.Results In the observation group, 21 cases were markedly effective, 28 cases effective and 3 cases ineffective. In the control group,13 cases were markedly effective, 28 cases effective, and 11 cases ineffective. The effective rate of the observation group was higher than that of the control group(P<0.05). The number of cerebrospinal fluid cells, protein content and intracranial pressure in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Sodium aesinate is effective in the treatment for the patients who received prior treatment of tuberculous meningitis. It can reduce the number of cerebrospinal fluid cells, protein content and intracranial pressure in the patients.
Key words:  Sodium aescinate  Tuberculous meningitis  Cerebrospinal fluid cell count  Protein  Intracranial pressure