| 摘要: |
| ［摘要］ 目的 探讨血白蛋白与球蛋白比值（AGR）对慢性阻塞性肺疾病急性加重期（AECOPD）患者预后评估的价值。方法 回顾性分析2016-01～2018-05于该院呼吸与危重症医学科以AECOPD为第一诊断入院的126例患者的临床资料，采用ROC曲线法获取AGR对预后结局的最佳截断值，并以此将研究对象分为高AGR组（AGR≥1.295）76例，低AGR组（AGR<1.295）50例。对两组的临床资料、实验室资料及预后情况进行比较。结果 高AGR组与低AGR组在性别、年龄、吸烟史、饮酒史和痰培养情况方面比较差异无统计学意义（P>0.05）；高AGR组的CRP、IL-6、PCT、合并感染人数、住院时间、出院1年内因急性加重需再次入院治疗人数及死亡人数低于低AGR组，BMI、FEV1%高于低AGR组，差异有统计学意义（P<0.05）。相关分析结果显示，AECOPD患者的AGR水平与CRP、IL-6、PCT、住院时间呈负相关，与BMI、FEV1%呈正相关（P<0.05）。结论 血AGR能够对AECOPD患者的预后结局进行预测，且有助于评估患者肺功能情况，为指导临床治疗提供了良好的参考指标。 |
| 关键词: 慢性阻塞性肺疾病 急性加重 白蛋白与球蛋白比值 预后 |
| DOI：10.3969/j.issn.1674-3806.2020.01.11 |
| 分类号:R 563 |
| 基金项目:河南省教育厅基础与前沿技术研究项目（编号：152300410051） |
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| Prognostic evaluation value of the ratio of albumin to globulin in patients with acute exacerbation of chronic obstructive pulmonary disease |
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WANG Sai-nan, LIU Jian-bo, HAN Xiao-peng, et al.
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Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Zhengzhou University, Henan 450000, China
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| Abstract: |
| ［Abstract］ Objective To explore the prognostic evaluation value of serum albumin to globulin ratio(AGR) in the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods A retrospective study was conducted on the clinical data of 126 patients admitted to the hospital with AECOPD as the first diagnosis from January 2016 to May 2018. The optimal cut-off value of AGR for prognostic outcome was obtained by receiver operating characteristic(ROC) curve method, and the study subjects were divided into high AGR group(AGR≥1.295, n=76) and low AGR group(AGR<1.295, n=50). The clinical data, laboratory data and prognosis were compared between the two groups. Results There were no significant differences in gender, age, smoking history, drinking history and sputum culture between the high AGR group and the low AGR group(P>0.05). The levels of C-reactive protein(CRP), interleukin-6(IL-6) and procalcitonin(PCT) in the high AGR group were significantly lower than those in the low AGR group(P<0.05). The number of co-infection, readmission due to acute exacerbation with 1 year of discharge from the hospital and death in the high AGR group was significantly less than those in the low AGR group(P<0.05). The hospitalization time of the high AGR group was shorter than that of the low AGR group(P<0.05). The levels of body mass index(BMI) and forced expiratory volume in 1 second(FEV1)% in the high AGR group were significantly higher than those in the low AGR group(P<0.05). The results of correlation analysis showed that the level of AGR was negatively correlated with CRP, IL-6, PCT and hospitalization time, and positively correlated with BMI and FEV1% in the AECOPD patients(P<0.05). Conclusion Blood AGR can predict the prognosis of the patients with AECOPD and help to assess the lung function of the patients, which provides a good reference for guiding clinical treatment. |
| Key words: Chronic obstructive pulmonary disease(COPD) Acute exacerbation Albumin to globulin ratio(AGR) Prognosis |
