| 摘要: |
| ［摘要］ 目的 探讨体外冲击波（ESW）联合中药独活寄生汤治疗早中期膝关节骨性关节炎（KOA）的疗效和安全性。方法 将360例（445膝）按患者治疗意愿分为中药独活寄生汤治疗组（A组）、单纯ESW治疗组（B组）、ESW联合中药独活寄生汤综合治疗组（C组），每组120例。分别对三组患者治疗前和治疗后2周、6周、12周、24周行VAS疼痛评分及Lysholm功能评分检查，以及膝关节液中一氧化氮（NO）、超氧化物歧化酶（SOD）等含量检测，并进行对比。结果 与治疗前比较，治疗后2周、6周、12周、24周，三组VAS疼痛评分均降低，Lysholm功能评分均提高，C组VAS疼痛评分、Lysholm功能评分与其他两组比较差异均有统计学意义（P<0.05）。三组患者治疗后2周、6周、12周、24周膝关节液中NO含量较治疗前降低，SOD含量较治疗前增高，差异有统计学意义（P<0.05）；C组与其他两组比较差异有统计学意义（P<0.05）。结论 ESW联合中药独活寄生汤综合治疗早中期KOA是一种具有多方面优越性的无创性可行技术，临床疗效确切，值得推广应用。 |
| 关键词: 体外冲击波 独活寄生汤 膝关节骨性关节炎 一氧化氮 超氧化物歧化酶 |
| DOI：10.3969/j.issn.1674-3806.2020.01.12 |
| 分类号:R 684.1 |
| 基金项目:广西医疗卫生适宜技术研究与开发项目（编号：S201313-05）；广西科学研究与技术开发计划项目（编号：桂科攻1598012-10）；广西医疗卫生适宜技术开发与推广应用项目（编号：S201643） |
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| Clinical study on the treatment of knee osteoarthritis with extracorporeal shock wave combined with Traditional Chinese Medicine Duhuo Jisheng decoction |
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WANG Hong-run, LI Hong-yu, JIN Xian-yue, et al.
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Department of Orthopedics, the People′ s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To explore the efficacy and safety of extracorporeal shock wave(ESW) combined with Traditional Chinese Medicine Duhuo Jisheng decoction in treatment of knee osteoarthritis(KOA). Methods Three hundred and sixty cases(445 knees) of KOA were divided into Chinese Medicine Duhuo Jisheng decoction treatment group(group A), simple ESW therapy group(group B), and ESW combined with Chinese Medicine Duhuo Jisheng decoction comprehensive treatment group(group C) according to the patients′ treatment intention, with 120 cases in each group. Visual Analogue Scale(VAS) scores and Lysholm function scores were measured in the three groups before and 2, 6, 12 and 24 weeks after treatment, and the concentrations of nitric oxide(NO) and superoxide dismutase(SOD) in the knee joint fluid were detected and compared among the three groups. Results Compared with those before treatment, VAS scores decreased and Lysholm function scores increased 2, 6, 12, and 24 weeks after treatment in the three groups. There were significant differences in VAS scores and Lysholm function scores between group C and the other two groups(P<0.05). Compared with those before treatment, the concentrations of NO in the knee joint fluid were significantly decreased and the concentrations of SOD in the knee joint fluid were significantly increased in the three groups 2, 6, 12, and 24 weeks after treatment(P<0.05), and there was significant difference between group C and the other two groups(P<0.05). Conclusion The comprehensive treatment of KOA by ESW combined with Chinese Medicine Duhuo Jisheng decoction is a non-invasive and feasible technology with many advantages. It has a definite clinical effect and is worth applying in clinics. |
| Key words: Extracorporeal shock wave(ESW) Duhuo Jisheng decoction Knee osteoarthritis(KOA) Nitric oxide(NO) Superoxide dismutase(SOD) |
