| 摘要: |
| ［摘要］ 二甲双胍为治疗2型糖尿病（T2DM）应用最广泛的降糖药物，对治疗糖尿病有良好的疗效，且有较高的安全性及卫生经济学效益，其对心血管疾病及并发症、慢性肾功能不全、多囊卵巢综合征、肿瘤等也发挥了作用，功效和机制正逐渐被阐明。该文就二甲双胍的多效能药理作用作一综述，以期为该药在临床的新应用提供依据。 |
| 关键词: 二甲双胍 心血管疾病 慢性肾病 多囊卵巢综合征 肿瘤 |
| DOI：10.3969/j.issn.1674-3806.2021.04.22 |
| 分类号:R 969.2 |
| 基金项目: |
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| Research progress in multipotent pharmacological action of metformin |
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YANG Zhou-sheng, CHEN Xiao-yu
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Department of Pharmacy, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Metformin is one of the most widely used oral glucose-lowering drugs in the treatment of type 2 diabetes mellitus(T2DM). It has a good curative effect on diabetes, and has relatively high safety and health economic benefits. In addition to the hypoglycemic effect, metformin also plays a role in cardiovascular disease and complications, chronic renal insufficiency, polycystic ovary syndrome and tumor, and the effects and mechanisms of metformin of these diseases are gradually being elucidated. In this paper, the research progress in multipotent pharmacological action of metformin is reviewed to provide evidence for the new clinical applications of the drug. |
| Key words: Metformin Cardiovascular disease Chronic kidney disease Polycystic ovary syndrome(PCOS) Tumor |
