| 摘要: |
| ［摘要］ 肝癌的复发转移是影响肝癌患者预后的关键。血管包绕肿瘤细胞巢（VETC）癌巢型肝细胞癌的转移方式无法用上皮-间质转化（EMT）理论来解释，其可以内皮细胞包绕肿瘤细胞团的形式发生整体转移，转移过程中肿瘤细胞不会发生EMT，VETC癌巢型肝细胞癌更易发生转移，转移效率更高，术后更易复发，预后更差。该文对VETC癌巢型肝细胞癌的分型、分子学特征、诊断、治疗及预后等进行评价和介绍，从而提高临床医师及研究人员对该类肝癌诊治的认识。 |
| 关键词: 肝细胞癌 血管包绕肿瘤细胞巢 诊断 治疗 预后 |
| DOI：10.3969/j.issn.1674-3806.2021.06.01 |
| 分类号:R 735.7 |
| 基金项目:国家自然科学基金项目（编号：81560406） |
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| Research progress of VETC carcinoma nest-type hepatocellular carcinoma |
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YANG Jian-rong, LIU Tian-qi, ZHENG Shu-sen, et al.
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Department of Hepatobiliary, Pancreas and Spleen Surgery, Guangxi Academy of Medical Sciences, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Relapse and metastasis are the key factors affecting the prognosis of patients with hepatocellular carcinoma(HCC). The metastasis mechanisms of vessels encapsulated tumor clusters(VETC) carcinoma nest-type HCC can not be explained by the theory of epithelial-to-mesenchymal transition(EMT). In VETC carcinoma nest-type HCC, tumor cells do not metastasize through EMT, but metastasize to other organs in carcinoma nest form in which VETC carcinoma nest-type HCC is encapsulated by endothelial cells. VETC carcinoma nest-type HCC is more likely to have metastasis and higher metastatic efficiency, and is more likely to relapse after operation, resulting in a worse prognosis. This paper evaluates and introduces the classification, molecular characteristics, diagnosis, treatment and prognosis of VETC carcinoma nest-type HCC, so as to improve the understanding of clinicians and researchers on the diagnosis and treatment of VETC carcinoma nest-type HCC. |
| Key words: Hepatocellular carcinoma(HCC) Vessels encapsulated tumor clusters(VETC) Diagnosis Therapy Prognosis |
