| 摘要: |
| ［摘要］ 目的 探讨HCV核心抗原(HCV-cAg)检测在丙型肝炎感染早期诊断中的应用价值。方法 选择2020年1月至2021年7月西南医科大学附属医院接治的HCV-cAg阳性患者90例和丙型肝炎抗体（HCV-Ab）阳性患者164例作为研究对象，测定其血清谷丙转氨酶（ALT）和丙型肝炎病毒核酸（HCV-RNA）水平。以核酸检测结果为金标准，分析HCV-cAg检测在丙肝感染早期诊断中的有效性。结果 90例HCV-cAg阳性患者中，HCV-RNA阳性76例（84.44%），肝功能异常54例（60.00%）。164例HCV-Ab阳性患者中，HCV-RNA阳性114例（69.51%），肝功能异常75例（45.73%）。HCV-cAg阳性组的HCV-RNA阳性率和肝功能异常率都显著高于HCV-Ab阳性组（P<0.05），并且HCV-cAg的S/CO值与肝功能异常率存在关联性（P<0.05）。结论 HCV-cAg检测结果能反映肝功能状态，可用于丙型肝炎的早期筛查及疗效评估。 |
| 关键词: 丙型肝炎 核心抗原 丙型肝炎抗体 谷丙转氨酶 早期诊断 |
| DOI：10.3969/j.issn.1674-3806.2022.12.14 |
| 分类号:R 512.6+3 |
| 基金项目:西南医科大学校级大创项目（编号：2021488） |
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| A study on the application of HCV-cAg detection in early diagnosis of hepatitis C infection |
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JIANG Ling, LI Sheng, WANG Zhi-yao, et al.
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Department of Blood Transfusion, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the application value of hepatitis C virus core antigen(HCV-cAg) detection in early diagnosis of hepatitis C infection. Methods Ninety patients with HCV-cAg positive and 164 patients with hepatitis C virus antibody(HCV-Ab) positive who received treatment in the Affiliated Hospital of Southwest Medical University from January 2020 to July 2021 were selected as the research subjects. The levels of glutamic-pyruvic transaminase(ALT) and hepatitis C virus ribonucleic acid(HCV-RNA) in the patients′ serum were detected, and nucleic acid test results were used as the gold standard to analyze the effectiveness of HCV-cAg detection in the early diagnosis of hepatitis C infection. Results Among the 90 cases of HCV-cAg positive specimens, 76 cases were positive for HCV-RNA, with the positive rate being 84.44%, and 54 cases were abnormal liver function, with the abnormal rate being 60.00%. Among the 164 cases of HCV-Ab positive, 114 cases(69.51%) were HCV-RNA positive, and 75 cases(45.73%) had abnormal live function. The rate of positive HCV-RNA and abnormal liver function in the HCV-cAg positive group were significantly higher than those in the HCV-Ab positive group(P<0.05), and the sample′s optical density/cut-off(S/CO) value of HCV-cAg was associated with abnormal liver function(P<0.05). Conclusion The detection results of HCV-cAg can reflect the liver function status, and can be used for early screening and efficacy evaluation of hepatitis C. |
| Key words: Hepatitis C Hepatitis C virus core antigen(HCV-cAg) Hepatitis C virus antibody(HCV-Ab) Glutamic-pyruvic transaminase(ALT) Early diagnose |
