| 摘要: |
| ［摘要］ 目的 探讨前列地尔辅助血管介入治疗糖尿病足的抗炎以及抗氧化作用。方法 选取2013-04～2015-06在该院接受治疗的糖尿病足患者100例，随机分为观察组和对照组各50例，对照组患者采用常规治疗，观察组患者采用前列地尔辅助血管介入治疗，比较两组患者治疗后临床症状改善、血清炎症因子改善以及血管功能改善情况等。结果 治疗后，两组患者的高敏C反应蛋白、肿瘤坏死因子以及白细胞介素6都有所下降，观察组低于对照组，差异有统计学意义（P<0.05）；治疗后观察组患者的疼痛缓解、麻木改善、跛行距离延长以及冷感改善情况明显优于对照组，差异有统计学意义（P<0.05）；治疗后，两组患者的内膜中层厚度、收缩期血管峰值血流速度以及（DI-DO）/DO都有所下降，观察组低于对照组，差异有统计学意义（P<0.05）。结论 前列地尔辅助血管介入治疗，能够显著地改善患者的炎症反应，改善患者下肢血管功能，效果显著。 |
| 关键词: 前列地尔 血管介入 糖尿病足 |
| DOI：10.3969/j.issn.1674-3806.2017.01.04 |
| 分类号:R 587 |
| 基金项目:肇庆市科技创新计划项目（编号：2014E212） |
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| The effects of alprostadil adjuvant with endovascular intervention on anti-inflammation and antioxidation in patients with diabetic feet |
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SU Rong-bin, SU Yong-cai, FENG Xin-wu, et al.
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Department of Cardiovascular Medicine, the First People′s Hospital of Zhaoqing, Guangdong 526000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the anti-inflammatory and antioxidant effects of alprostadil assisted endovascular interventional treatment for diabetic foot.Methods One hundred patients with diabetic feet were selected from our hospital during April 2013 and June 2015, and they were randomly divided into the observation group（n=50） and the control group（n=50）. The control group was treated with conventional treatment, and the observation group was treated with alprostadil adjuvant with endovascular interventional treament. The improvements of the clinical symptoms, serum inflammatory cytokines and vascular function were compared between the two groups before and after the treatment.Results After the treatment, the high-sensitivity C-reactive protein, tumor necrosis factor and interleukin-6 were decreased in both of the two groups which were significantly lower than those in the control group(P<0.05). The improvement of pain relief, numbness and claudication distance extended and the improvement of sensation in the observation group were better than those in the control group(P<0.05). The intima-media thickness, systolic peak velocity and vascular(DI-DO)/DO were decreased in both of the two groups, with singnificantly lower ones in the observation group than those in the control group(P<0.05).Conclusion Alprostadil adjuvant with endovascular intervention can significantly improve the inflammatory response and the vascular function in lower limbs of the patients with diabetic feet. |
| Key words: Alprostadil Vascular intervention Diabetic foot |
