摘要: |
[摘要] 目的 探讨噻托溴铵联合肺康复治疗对稳定期慢阻肺患者肺动脉压力及其生活质量改善的影响。方法 选取该院2012-07~2014-03收治的稳定期慢阻肺患者72例作为研究对象,按治疗方式不同将其分为两组,对照组(n=35)给予6个月的肺康复治疗,治疗组(n=37)在肺康复治疗的基础上给予噻托溴铵治疗,比较两组患者间接肺动脉收缩压、血气分析及生活质量改善情况。结果 两组患者治疗前生活质量评分无明显差异(P>0.05),治疗组患者治疗后生活质量评分明显低于对照组,组间比较差异有统计学意义(P<0.05);两组患者治疗前6 min步行距离无明显差异,治疗后治疗组患者6 min步行距离明显长于对照组,差异具有统计学意义(P<0.05);两组患者治疗前肺动脉收缩压比较无明显差异,治疗后治疗组患者肺动脉收缩压明显低于对照组,差异具有统计学意义(P<0.05)。治疗后两组PaCO2值和PaO2值差异有统计学意义(P<0.05)。结论 应用噻托溴铵与肺康复治疗,可使稳定期慢阻肺患者生活质量得到明显的改善,降低其肺动脉压力,值得应用推广。 |
关键词: 慢性肺阻塞 肺康复 噻托溴铵 肺动脉压 生活质量 |
DOI:10.3969/j.issn.1674-3806.2017.01.23 |
分类号:R 56 |
基金项目: |
|
The effects of tiotropium bromide combined with pulmonary rehabilitation on pulmonary artery pressure and the quality of life in patients with stable chronic obstructive pulmonary disease |
LI Yu-hu
|
Department of Respiratory, the Hospital of Jiangmen City, Guangdong 529000, China
|
Abstract: |
[Abstract] Objective To explore the effects of tiotropium bromide combined with pulmonary rehabilitation on pulmonary artery pressure and the quality of life in patients with stable chronic obstructive pulmonary disease(COPD).Methods Seventy-two patients with stable COPD were collected from July 2012 to March 2014 and were divided into two groups. The control group(n=35) received pulmonary rehabilitation for six months,and the treatment group(n=37) was treated with pulmonary rehabilitation in combination with tiotropium bromide. The indirect systolic pulmonary artery pressure,blood analysis and the improvement of quality of life were compared between the two groups.Results The scores of quality of life were not significantly different between the two groups before the treatment(P>0.05). The treatment group had significantly lower scores of quality of life than the control group after the treatment(P<0.05). There was no significant difference in 6 Minute Walking Test between the two groups before the treatment. The walking distance of 6 minutes in the treatment group was significantly longer than that in the control group(P<0.05) after the treatment. There was no significant difference between the two groups in pulmonary artery systolic pressure before the treatment. The treatment group had significantly lower pulmonary artery systolic pressure than the control group after the treatment(P<0.05). Blood gas analysis showed significant differences in PaCO2 and PaO2 values between the two groups after the treatment(P<0.05).Conclusion Tiotropium bromide in combination with pulmonary rehabilitation can reduce the pulmonary arterial pressure and improve the quality of life in the patient with stable COPD. |
Key words: Chronic pulmonary obstruction Pulmonary rehabilitation Tiotropium bromide Pulmonary artery pressure Quality of life |