| 摘要: |
| ［摘要］ 微小RNA（MicroRNA，miRNA）的差异性表达与多种疾病的发生、发展相关，许多研究已证实miRNA在肠易激综合征（IBS）发病中也起着关键作用，据此提出某些特定的miRNA或将成为IBS特异性诊断和治疗的新工具。近年来发现微泡（Microvescles，MV）是机体内miRNA转运的关键媒介，因此在将来的研究中或许可以利用MV作为载体，向体内转染经沉默或过表达后的特殊miRNA。该文对miRNA在肠易激综合征诊断和治疗中的研究进展进行了综述。 |
| 关键词: 肠易激综合征 miRNA 微泡 诊断 治疗 |
| DOI：10.3969/j.issn.1674-3806.2017.01.28 |
| 分类号:R 574 |
| 基金项目:国家自然科学基金资助项目（编号：81160053） |
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| MicroRNA-a potential diagnostic and therapeutic tool for IBS |
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LIANG De-jiao, LIANG Lie-xin, ZHANG Fa-can
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Department of Gastroenterology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ The dysregulation of miroRNAs(miRNAs) is associated with many diseases. Evidences show that it also plays an important role in the occurrence of irritable bowel syndrome(IBS). Some special miRNAs may be both diagnostic and therapeutic tools for IBS. During the last several years, blood microvesicles(MV) have been found that they are pivotal physiological vehicles to deliver miRNAs in human beings. Thus, it is possible to use MV as vehicles to deliver miRNAs inhibitor vector(or miRNA precursor) in vivo in the future studies. |
| Key words: Irritable bowel syndrome（IBS） miRNA Microvesicle Diagnose Therapy |
