| 摘要: |
| ［摘要］ 目的 探讨帕金森病患者出现认知功能障碍的危险因素,为临床预防治疗提供参考。方法 对165例帕金森病患者采用帕金森病统一评分量表(UPDRS)、蒙特利尔认知评估量表(MoCA)、汉密尔顿抑郁量表(HAMD)、H-Y分级量表进行调查分析引起认知功能障碍发生的危险因素。结果 MoCA调查显示帕金森病患者认知功能障碍发生率为51.51%;无认知功能障碍组病程、HAMD评分、H-Y分级、PUDRS Ⅱ评分、PUDRS Ⅲ评分低于认知功能障碍组；多因素Logistic回归分析显示受教育年限（OR=0.096）、病程（OR=2.626）、HAMD评分（OR=4.038）、H-Y分级（OR=9.157）、PUDRS Ⅱ评分（OR=2.223）是帕金森病患者发生认知功能障碍的独立危险因素。结论 受教育年限、病程、HAMD评分得分、H-Y分级、PUDRS Ⅱ评分得分是帕金森病患者发生认知功能障碍的相关危险因素，应加以关注，及早干预，以期减少或延缓认知功能障碍的发生。 |
| 关键词: 帕金森病 认知功能障碍 危险因素 |
| DOI：10.3969/j.issn.1674-3806.2017.03.05 |
| 分类号:R 741 |
| 基金项目:广西卫计委科研课题（编号：Z2014623） |
|
| The risk factors of cognitive dysfunction in Parkinson′s disease |
|
WEI Chun-ying, HAN Min, MO Ying-min, et al.
|
|
The Cadre Ward in Department of Neurology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the risk factors of cognitive dysfunction in Parkinson′s disease.Methods The risk factors of cognitive dysfunction in 165 patients with Parkinson′s disease were assessed by Unified Parkinson′s disease rating scale(UPDRS), Montreal cognitive assessment scale(MoCA), Hamilton depression scale(HAMD) and H-Y rating scale.Results The survey results of MoCA showed that the incidence of cognitive dysfunction in Parkinson′s disease was 51.51%. Course of the disease, HAMD score, H-Y grading, PUDRS Ⅱ score and PUDRS Ⅲ score in the noncognitive dysfunction group were significantly shorter or lower than those in the cognitive dysfunction group. Multiple logistic regression analysis demonstrated that the education years（OR=0.096）, course of the disease（OR=2.626）, HAMD score（OR=4.038）, H-Y grading（OR=9.157） and PUDRS Ⅱ score（OR=2.223）were the independent risk factors(P<0.05).Conclusion The education years, course of the disease, HAMD score, H-Y grading,and PUDRS Ⅱ score are the related risk factors of cognitive dysfunction in Parkinson′s disease. More attention and early intervention should be focused on the patients to reduce or delay the occurrence and progress cognitive dysfunction. |
| Key words: Parkinson′s disease Cognitive dysfunction Risk factors |
