| 摘要: |
| ［摘要］ 目的 通过动态监测婴幼儿喘息患儿治疗前后呼出气一氧化氮(FeNO)浓度变化，评价FeNO在婴幼儿喘息性疾病中的临床作用。方法 根据哮喘预测指数(API)将105例婴幼儿喘息患儿分为哮喘预测指数阳性组（APIP组）62例和哮喘预测指数阴性组（APIN组）43例，并设健康对照组20例。检测并比较APIP组和APIN组婴幼儿喘息患儿急性发作期、治疗后1个月、3个月FeNO浓度变化趋势。结果 APIP组患儿在喘息发作期、治疗后1个月、3个月FeNO值均显著高于APIN组（P均<0.05）及对照组（P均<0.05）；而APIN组患儿在喘息发作期、治疗后1个月高于对照组（P均<0.05），治疗后3个月降至正常水平。APIP组、APIN组患儿在治疗后1个月、3个月FeNO值均低于喘息发作期（P均<0.05）。结论 FeNO可以反映婴幼儿喘息患儿气道炎症及程度，对婴幼儿喘息患儿抗炎药物的使用具有临床指导意义。 |
| 关键词: 喘息 婴幼儿 呼出气一氧化氮 哮喘预测指数 |
| DOI：10.3969/j.issn.1674-3806.2017.04.02 |
| 分类号:R 725.6 |
| 基金项目:广西医疗卫生适宜技术研究与开发项目（编号：S201551） |
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| Study on fractional exhaled nitric oxide in infants and toddlers with recurrent wheeze |
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WEN Zhi-hong, YANG Ying-jie, WANG Mei-chun, et al.
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Department of Pediatrics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the clinical value of fractional exhaled nitric oxide(FeNO) in wheezy infants and toddlers with asthma predictive index positive(API-positive) or asthma predictive index negative（API-negative） by continuously monitoring the concentrations of FeNO.Methods A total of 105 wheezy infants and toddlers were enrolled as the experimental subjects and were divided into API-positive group and API-negative group.Twenty healthy children were collected as the control group. The levels of FeNO were determined using the off-line tidal breathing technique in the acute stage, the first month and the third month after the treatment and the levels of FeNO were compared among the three groups.Results The FeNO levels of the API-positive group were significantly higher than those of the API-negative group and those of the control group in the acute stage or on the first month and the third month after the treatment(P<0.05). In the API-negative group, the FeNO levels of wheezy cases on the first month after the treatment were still significantly higher than those of the controls(P<0.05), but the FeNO levels decreased to the normal level on the third month. In the API-positive group and the API-negative group, the FeNO levels of wheezy cases were significantly lower than those of the controls both on the first month and on the third month after the treatment(P<0.05).Conclusion Continuously monitoring concentration of FeNO may be used to reflect the airway inflammation in the infants and toddlers with recurrent wheeze and FeNO may be contributed to the guideline of anti-inflammation therapy. |
| Key words: Wheeze Infants and toddlers Fractional exhaled nitric oxide Asthma predictive index |
