| 摘要: |
| ［摘要］ 目的 分析地屈孕酮与黄体酮在早期先兆流产患者中的应用效果。方法 选取该院生殖科早期先兆流产患者100例，根据治疗方法不同分为观察组和对照组各50例。观察口服地屈孕酮治疗，对照组肌肉注射黄体酮治疗。对比两组疗效、流产率、临床症状消失时间、不良反应发生率，以及治疗前后两组雌二醇（E2）及血人绒毛膜促性腺激素（HCG）水平。结果 治疗后2 d观察组E2略高于对照组（P<0.01）；治疗后4 d两组患者血HCG水平均高于治疗前（P<0.05），但两组比较差异无统计学意义（P>0.05）；观察组临床症状消失时间短于对照组（P<0.01）；观察组治疗总有效率略高于对照组，但差异无统计学意义（P>0.05）；观察组流产率与对照组比较差异无统计学意义（P>0.05）；观察组不良反应发生率低于对照组，差异有统计学意义（P<0.05）。结论 地屈孕酮应用效果与黄体酮相似，但地屈孕酮能减少不良反应，缩短治疗时间，安全性高，服用更方便，值得临床应用。 |
| 关键词: 地屈孕酮 黄体酮 早期先兆流产 疗效 |
| DOI：10.3969/j.issn.1674-3806.2017.04.10 |
| 分类号:R 714.21 |
| 基金项目: |
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| Comparison of the clinical effect between progesterone and flexor progesterone on the patients with early threatened abortion |
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WU Ting-ting, LI Xiao-fang
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Department of Reproductive Science, the Fourth People′s Hospital of Linfen City, Shanxi 041000, China
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| Abstract: |
| ［Abstract］ Objective To compare the clinical effect between progesterone and flexor progesterone on the patients with early threatened abortion.Methods 100 patients with early threatened abortion were collected and were randomly divided into the observation group(flexor progesterone) and the control group(progesterone) according to the different treatments. The curative effect, the abortion rate, the symptoms disappear time, the incidence of adverse reactions and the levels of estradiol(E2) and blood human chorionic gonadotropin(HCG) were compared between the two groups before and after the treatment.Results The E2 of the observation group was significantly higher than that of the control group two days after the treatment(P<0.01). The levels of blood HCG in both of the two groups fours days after the treatment were significantly higher than those before the treatment(P<0.05), however there was no significant difference between the two groups after the treatment(P>0.05). The clinical symptom disappear time of the observation group was significantly shorter than that of the control group(P<0.01). The clinical effect of the observation group was slightly higher than that of the control group, without a statistically significant difference(P>0.05). There was no statistically significant difference in the spontaneous abortion rate between the two groups(P>0.05). The adverse reaction rate of the control group was significantly higher than that of the observation group(P<0.05).Conclusion Flexion progesterone and progesterone have a similar clinical effect on the treatment of early threatened abortion but flexion progesterone is safer and more convenient than progesterone. |
| Key words: Flexor progesterone Progesterone Early threatened abortion Curative effect |
