| 摘要: |
| ［摘要］ 目的 探讨白介素22（IL-22）与冠状动脉钙化的关系以及预测价值。方法 将202例研究对象根据冠状动脉CT检查计算钙化积分结果分为低钙化积分组（LCAC，总积分≤300）146例，为非冠心病者；高钙化积分组（HCAC，总积分>300）56例，为冠心病者。通过ELISA法测定不同组别血清IL-22水平。结果 LCAC组IL-22为(28.34±12.63)pg/ml，HCAC组IL-22为(38.59±12.90)pg/ml（t=-6.12，P<0.001）。相关性分析提示血清IL-22水平与冠脉钙化积分(CCS)有明显相关性（r=0.42，P<0.01）。IL-22诊断冠状动脉钙化的ROC曲线下面积为0.871，最佳临界值为27.50 pg/ml，此时敏感度为85%,特异度为71%。结论 严重冠状动脉钙化者血清IL-22水平显著增高，血清IL-22可能可以作为冠状动脉钙化预测因子。 |
| 关键词: 白介素22 冠状动脉钙化 |
| DOI：10.3969/j.issn.1674-3806.2017.05.01 |
| 分类号:R 543.5 |
| 基金项目:国家自然科学基金资助项目（编号：81360055）；广西科学研究与技术开发计划项目（编号：桂科攻14124003-9）；广西卫计委科研课题（编号：Z2014213） |
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| Study on the correlation between serum IL-22 and coronary artery calcification |
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YANG Zi-cong, LIU Yu, GAN Jian-ting, et al
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Department of Cardiology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the correlation between serum IL-22 and coronary artery calcification and the predictive value of IL-22 in vascular calcification.Methods 202 patients were divided into low calcification group(LCAC, total scores≤300, with non-coronary heart disease, n=146), and calcification group(HCAC, high total scores>300, with coronary heart disease, n=56). The levels of serum IL-22 were determined by ELISA.Results The levels of IL-22 were (28.34±12.63)pg/ml in the LCAC group and (38.59±12.90)pg/ml in the HCAC group(t=-6.12, P<0.001). The statistic results showed that there was a significant correlation between the level of serum IL-22 and the coronary calcification scores(HCAC: r=0.42, P<0.01). The area under ROC curve of IL-22 was 0.871, and the optimal critical value was 27.50 pg/ml, with a sensitivity of 85% and a specificity of 71%.Conclusion The level of serum IL-22 is significantly increased in the patients with severe coronary artery calcification, which may be used as a predictor of coronary artery calcification. |
| Key words: Interleukin 22 Coronary artery calcification |
