| 摘要: |
| ［摘要］ 白血病化疗药物如环磷酰胺、吉西他滨、柔红霉素等可引起不同程度的血小板减少,进而导致皮肤黏膜及重要脏器出血而使化疗终止,甚至危及生命。目前临床上主要是通过输注血小板、应用促血小板生成药物等展开对症治疗。该文对白血病化疗后血小板减少症的发病机制、输血治疗、rhTP0和rhIL-11等促血小板生长因子治疗等方面进行了综述。 |
| 关键词: 白血病 血小板减少症 化疗 重组人血小板生成素 |
| DOI：10.3969/j.issn.1674-3806.2017.05.28 |
| 分类号:R 733.7 |
| 基金项目: |
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| Research progress in the treatment of thrombocytopenia associated with leukemia chemotherapy |
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HU Xiao-liang, TAO Jie
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Shanxi Medical University, Taiyuan 030001, China
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| Abstract: |
| ［Abstract］ Chemotherapeutic drugs applied to treating leukemia such as cyclophosphamide,gemcitabine, daunorubicin and so on can cause thrombocytopenia in varying degrees, leading to bleeding of the skin mucous membrane and the internal organs, and even the termination of chemotherapy and life threatening. At present platelet transfusion and platelet growth factors such as recombinant human interleukin-11(rhIL-11), recombinant human thrombopoietin(rhTPO) have been used clinically to treat thrombocytopenia associated with leukemia chemotherapy. In this paper, the pathogenesis of thrombocytopenia after chemotherapy, and the treatments of platelet transfusion and platelet growth factors are reviewed. |
| Key words: Leukemia Thrombocytopenia Chemotherapy Recombinant human thrombopoietin(rhTPO) |
