| 摘要: |
| ［摘要］ 基质细胞衍生因子-1(stromal cell derived factor-1，SDF-1)属于趋化因子家族，与其受体CXCR4组成SDF-1/CXCR4轴,可以调节间充质干细胞（mesenchymal stem cell，MSC）促进慢性创伤的愈合。慢性创伤包括糖尿病足溃疡、动静脉溃疡、压力性溃疡等。利用SDF-1/CXCR4轴调节MSC向慢性创伤部位归巢促进愈合的特点，可以作为一种有潜力的治疗糖尿病足等慢性创伤的手段，该文主要对SDF-1/CXCR4轴调节MSC的作用机制和信号通路进行综述。 |
| 关键词: SDF-1/CXCR4轴 间充质干细胞 慢性创伤愈合 糖尿病足溃疡 |
| DOI：10.3969/j.issn.1674-3806.2017.06.32 |
| 分类号:R 587.2 |
| 基金项目:广西自然科学基金资助项目（编号：2013GXNSFAA278002） |
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| Research progress in the mechanism of SDF-1/CXCR4 axis in promotion of chronic wound healing |
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ZHANG Jie, XIANG Jie, QIN Ying-fen
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Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Stromal cell derived factor-1(SDF-1) belongs to the family of chemokines.SDF-1/CXCR4 axis plays an important role in mesenchymal stem cell homing to chronic wound healing and it can be a potential treatment for the diabetic patients with chronic wounds including diabetic foot ulcer, venous ulcer, arterial ulcer and stress ulcer. This review summarizes the research progress in the mechanism and signaling pathways of SDF-1/CXCR4 axis in regulation of mesenchymal stem cell. |
| Key words: SDF-1/CXCR4 axis Mesenchymal stem cell Chronic wound healing Diabetic foot ulcer |
