| 摘要: |
| ［摘要］ 目的 分析妊娠期肝内胆汁淤积症（ICP）孕妇临床特点及妊娠结局。方法 回顾性分析2015-01～2016-01产科收治的135例ICP孕妇（观察组）和同期分娩的135例非ICP孕妇（对照组），比较两组孕妇临床生化指标和羊水污染率、早产率、胎儿窘迫发生率、围产儿病死率、剖宫产率及孕妇产后出血量。结果 （1）观察组总胆汁酸（TBA）、总胆红素（TB）、直接胆红素（DB）、丙氨酸转氨酶（ALT）和门冬氨酸转氨酶（AST）表达水平均明显高于对照组，差异有统计学意义（P<0.05）；（2）观察组羊水污染率、早产率、胎儿窘迫发生率、围产儿病死率、剖宫产率及产后出血率均明显高于对照组，且产后出血量明显多于对照组，差异均有统计学意义（P<0.05）。结论 ICP患者血清总胆汁酸水平明显升高，且妊娠结局常有明显不良预后，胎儿尤为明显，所以临床上应定时监测其TBA水平，及时予以相应治疗措施，减少或避免胎儿不良预后的发生，改善妊娠结局。 |
| 关键词: 妊娠期 肝内胆汁淤积症 妊娠结局 |
| DOI：10.3969/j.issn.1674-3806.2017.07.22 |
| 分类号:R 714 |
| 基金项目: |
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| Clinical analysis of 135 pregnant women with intrahepatic cholestasis during pregnancy and their pregnant outcomes |
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LIU Li-na, WU Wei-qi
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Department of Gynecology and Obstetrics, the Second People′s Hospital of Xinxiang, Henan 453000, China
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| Abstract: |
| ［Abstract］ Objective To analyze the clinical features of pregnant women with intrahepatic cholestasis of pregnancy(ICP) and their pregnant outcomes.Methods From January 2015 to January 2016, a total of 270 pregnant women in our hospital were taken as the research subjects, and they were divided into the observation group(n=135, with ICP） and the control group(n=135, normal pregnancy）. The clinical biochemical indicators, the incidence of amniotic fluid contamination, the premature birth rate, the fetal distress rate, the perinatal mortality rate, the cesarean section rate and postpartum hemorrhage volume were compared between the two groups.Results The levels of TBA, TB, DB, ALT and AST in the observation group were higher than those in the control group（P<0.05）. The incidence of amniotic fluid contamination, the premature birth rate, the fetal distress rate, the perinatal mortality rate, the cesarean section rate and postpartum hemorrhage volume in the observation group were higher than those in the control group（P<0.05）.Conclusion The serum levels of total bile acid are significantly increased in the ICP patients, and they have poor pregnant outcomes and unfavourable prognoses. |
| Key words: Pregnancy Intrahepatic cholestasis of pregnancy Pregnant outcomes |
