| 摘要: |
| ［摘要］ 爆震性耳聋是一种常见的职业病，在军事、矿业人员中尤为突出。它是由爆震波引起的爆震或间断性脉冲噪声引起的外耳、中耳及内耳不同程度损伤，从而造成耳鸣、耳聋、耳痛等一系列临床症状。近年来研究发现，爆震不仅会引起听觉系统的机械性损伤造成耳聋，还会引发一系列分子级联反应和细胞过程，如氧化应激增加、耳蜗血流量减少、血管收缩、谷氨酸兴奋性毒性、钙浓度增加等。根据这些分子变化机制，研发相应的药物或寻找分子靶点，将有助于改善爆震性耳聋的预防和治疗。该文对爆震性耳聋的研究概况作一综述。 |
| 关键词: 爆震波 爆震性耳聋 氧自由基 钙稳态 神经营养因子 |
| DOI：10.3969/j.issn.1674-3806.2017.07.36 |
| 分类号:R 764 |
| 基金项目: |
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| Progress of research on explosive deafness |
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LIU Tong, CHEN Zi-long, ZHU Xiao-fen
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Progress of research on explosive deafness
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| Abstract: |
| ［Abstract］ Explosive deafness is a common occupational disease, especially for the military personnel. Explosive deafness is the primary blast injury caused by blast waves, which can induce blast damage to the outer ears, middle ears and inner ears and lead to a series of clinical symptoms, such as deafness, tinnitus and earache. Recently, several studies suggest that blast not only caused mechanical injury of auditory system, but also initiated a series of molecular cascade reactions and cellular processes, such as increasing oxidative stress, decreasing cochlear blood flow, blood vessel contraction, glutamate excitability toxicity, and increasing calcium concentration in cells. Finding safe and effective interventions that attenuate explosive deafness according to these molecular mechanism will be helpful for the prevention and treatment of acquired hearing loss. The progress of research on explosive deafness is reviewed in this paper. |
| Key words: Blast wave Explosive deafness Oxygen free radical Calcium homeostasis Neurotrophic factors |
