| 摘要: |
| ［摘要］ 目的 通过观察上皮细胞-间质转型（EMT）通路相关蛋白跨膜丝氨酸蛋白酶TMPRSS4（transmembrane protease serine 4，TMPRSS4）在非小细胞肺癌患者手术切除的肺癌组织、癌旁组织中的表达，探讨TMPRSS4蛋白水平表达与非小细胞肺癌的临床关系。方法 应用免疫组织化学SP法检测45例非小细胞肺癌及其配对癌旁组织中TMPRSS4蛋白的表达情况。结果 非小细胞肺癌组织中TMPRSS4蛋白阳性表达率为60.00%，癌旁组织中TMPRSS4阳性表达率为4.44%；癌组织中TMPRSS4蛋白阳性表达率明显高于癌旁正常肺组织（χ2=29.31,P<0.01）。TMPRSS4蛋白表达与非小细胞肺癌淋巴结转移、临床分期相关（P<0.05）。结论 TMPRSS4在非小细胞肺癌中的表达与肿瘤发生、转移密切相关，高表达的TMPRSS4蛋白提示肺癌有转移风险更高及预后更差的可能，TMPRSS4可能成为非小细胞肺癌中一个新的研究方向。 |
| 关键词: Ⅱ型跨膜丝氨酸蛋白酶 免疫组化S-P法 非小细胞肺癌 |
| DOI：10.3969/j.issn.1674-3806.2017.10.05 |
| 分类号:R 734.2 |
| 基金项目:南宁市科研项目（编号：20143180） |
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| Expression of TMPRSS4 protein in NSCLC and its clinical significances |
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LI Shou-nan, WU Zheng-qiu, LU Qiang-chang, et al.
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Department of Cardiothoracic Surgery, the People′s Hospital of Binyang County, Guangxi 530405, China
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| Abstract: |
| ［Abstract］ Objective To investigate the expression of transmembrane protease serine 4(TMPRSS4) protein in non-small-cell lung cancer(NSCLC) and its clinical significances.Methods The expressions of TMPRSS4 were detected in the tissues of NSCLC and their matched adjacent normal tissues in 45 patients by the immunohistochemical streptavidin peroxidase(SP) technique.Results The positive expression rate of TMPRSS4 was 60.0% in the NSCLC cancer tissues, and 4.44% in the matched adjacent normal tissues. The positive expression rate of TMPRSS4 in the NSCLC tissues was significantly higher than that in the pericarcinomatous tissues(χ2=29.31, P<0.01). The expression of TMPRSS4 protein was related to the metastasis and clinical stages of NSCLC.Conclusion The expression of TMPRSS4 protein is related to the metastasis and clinical stages of NSCLC and the overexoression of TMPRSS4 indicates the high risk of metastasis and poor prognosis, which may be a novel research hotspot in NSCLC. |
| Key words: Transmembrane protease serine 4(TMPRSS4) Immunohistochemical streptavidin peroxidase(SP) technique Non-small-cell lung cancer(NSCLC) |
