| 摘要: |
| ［摘要］ 目的 探讨稳定型心绞痛患者服用尼可地尔治疗对冠状动脉微循环阻力指数（IMR）的影响。方法 选取2014-03～2016-03该院收治的56例拟行介入术治疗的稳定型心绞痛患者，根据入院时间随机分为研究组和对照组，每组28例。两组入院后均给予常规药物治疗，对照组服用硝酸异山梨酯，研究组服用尼可地尔，均治疗4周，对治疗前后两组患者的IMR及临床效果进行比较分析。结果 治疗后，研究组的IMR为（16.87±4.71），低于对照组的（26.21±8.61），差异有统计学意义（P<0.05）。研究组显效14例，有效12例，无效2例。对照组显效9例，有效11例，无效8例。研究组疗效优于对照组（P<0.05）。结论 对稳定型心绞痛患者在常规用药基础上加服尼可地尔，可有效降低IMR，改善患者的冠状动脉微循环和心功能。 |
| 关键词: 稳定型心绞痛 尼可地尔 冠状动脉 微循环阻力指数 |
| DOI：10.3969/j.issn.1674-3806.2017.10.07 |
| 分类号:R 54 |
| 基金项目: |
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| Effect of oral administration of nicorandil on coronary microcirculation resistance index in patients with stable angina pectoris |
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HAN Wen-jie, LIU Heng-liang
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Department of Cardiovascular Medicine, the People′s Hospital of Zhengzhou, Henan 450000, China
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| Abstract: |
| ［Abstract］ Objective To explore the effect of oral administration of nicorandil on coronary microcirculation resistance index(IMR) in patients with stable angina pectoris.Methods 56 patients with stable angina pectoris treated from March 2014 to March 2016 were selected and randomly divided into the treatment group and the control group, with 28 cases in each group. The control group took isosorbide dinitrate, and the treatment group was treated with nicorandil treatment for 4 weeks. The clinical effect of IMR was compared between the two groups before and after treatment.Results After treatment, IMR of the treatment group (16.87±4.71) was lower than that of the control group (26.21±8.61), with a significant difference between the two groups(P<0.05). In the treatment group, 14 cases were markedly effective, 12 cases effective, and 2 cases ineffective. In the control group, 9 cases were markedly effective, 11 cases effective, and 8 cases ineffective. The curative effect of the treatment group was better than that of the control group(P<0.05).Conclusion Nicorandil can effectively reduce IMR and improve the coronary microcirculation and cardiac function on the basis of routine treatment for the patients with stable angina pectoris. |
| Key words: Stable angina Nicorandil Coronary artery Microcirculation resistance index |
