| 摘要: |
| ［摘要］ 目的 分析肾病综合征(nephrotic syndrome,NS)患儿停用激素1年后身高及骨代谢指标恢复情况，为临床预防性用药提供指导。方法 选取2015-07～2016-07该院就诊的停用糖皮质激素1年的原发NS患儿27例作为NS组，另选取同期27名健康儿童作为对照组，测定对照组和NS组血清骨保护素和骨钙素N-端中分子片段（N-MID）水平，记录两组儿童身高，计算身高标准差得分。结果 NS组血清骨保护素、骨钙素N-MID含量、身高标准差得分分别为（432±52）ng/L、（76±27）ng/ml、（-0.602±1.381），对照组各参数分别为（434±63）ng/L、（68±19）ng/ml、（-0.136±1.601），两组比较差异无统计学意义（均P>0.05）。结论 NS患儿停用糖皮质激素1年后骨代谢生化指标及身高水平可恢复至正常儿童水平。 |
| 关键词: 肾病综合征 糖皮质激素 儿童 骨代谢 恢复 |
| DOI：10.3969/j.issn.1674-3806.2017.10.16 |
| 分类号:R 725.8 |
| 基金项目: |
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| Recovery of the markers of bone metabolism after glucocorticoid withdrawal in children with nephrotic syndrome |
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LI Yu-liu, LIU Cui-hua, WANG Hua, et al.
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Department of Nephrology and Rheumatology, the Children′s Hospital of Zhengzhou City, Henan 450000, China
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| Abstract: |
| ［Abstract］ Objective To observe the recovery of the makers of bone metabolism and height in children with nephrotic syndrome(NS) after glucocorticoid withdrawal, and to provide the guidance for clinical preventive medications.Methods The levels of serum osteoprotegerin(OPG) and serum N-terminal midfragment of osteocalcin（ N-MID osteocalcin） were measured in 27 healthy children(the control group) and in 27 children with NS(the NS group) after the withdrawal of glucocorticoid therapy for one year, and the height and height standard different scores(HtSDS) were recorded in both of the two groups.Results There were no significant differences between the NS group and the control group in the levels of serum OPG［(432±52)ng/L vs (434±63 ng/L)］, N-MID osteocalcin［(76±27）ng/ml vs (68±19)ng/ml］ and HtSDS［(-0.602±1.381） vs (-0.136±1.601)］（P>0.05）.Conclusion The makers of bone metabolism and height levels in children with NS after the withdrawal of glucocorticoid therapy for one year may recover to those in normal children. |
| Key words: Nephrotic syndrome(NS) Glucocorticoid Children Bone metabolism Recovery |
