| 摘要: |
| ［摘要］ 目的 观察増液解毒汤治疗头颈部恶性肿瘤急性放射性口腔黏膜炎的临床疗效。方法 选取达州市中心医院2015-03～2016-07收治的头颈部恶性肿瘤患者共118例，随机分为试验组(n=59)和对照组(n=59)。两组均行同步放、化疗，试验组给予増液解毒汤煎服，对照组给予常规含漱液，观察两组口腔黏膜反应的情况。结果 （1）放疗20 Gy时，两组均出现不同程度黏膜反应，试验组为25.86%，对照组为44.64%。（2）放疗结束时，试验组口腔黏膜副作用发生率为56.90%，对照组为71.43%；试验组3、4级发生率为6.90%，对照组为17.86%。（3）对照组延迟放疗患者比率为28.57%，试验组为15.52%。（4）口腔黏膜炎给予其他干预治疗为对照组30.36%，试验组为13.79%。以上两组结果差异均有统计学意义（P<0.05）。结论 増液解毒汤能减轻患者急性口腔黏膜炎的程度，降低放疗时间延长率，减少其他干预治疗措施，值得临床推广。 |
| 关键词: 増液解毒汤 头颈部恶性肿瘤 急性放射性口腔黏膜炎 |
| DOI：10.3969/j.issn.1674-3806.2018.03.12 |
| 分类号:R 739.91 |
| 基金项目: |
|
| Clinical study of Zengyejiedu decoction on acute radioactive oral mucositis in patients with head-neck malignant carcinoma |
|
SONG Zhu-mei, SONG Hong-mei, GUI Jin-chuan, et al.
|
|
Department of Oncology, Dazhou Center Hospital, Sichuan 635000, China
|
| Abstract: |
| ［Abstract］ Objective To observe the clinical effect of Zengyejiedu decoction on acute radioactive oral mucositis in the patients with head-neck malignant carcinoma.Methods 118 patients who were diagnosed with head-neck malignant carcinoma in the department of oncology of Dazhou center hospital from March 2015 to July 2016 were randomly divided into the experimental group(n=59) and the control group(n=59). All the patients received concurrent radiochemtherapy, the experimental group was treated with oral Zengyejiedu decoction, while the control group received conventional gargle. The clinical effect on the treatment of acute radioactive oral mucositis was compared between the two groups.Results (1)With the dosage of radiation reaching 20 Gy, mucosa reaction appeared to some extent in some patients in the experimental group(25.86%) and the control group(44.64%); (2)After the radiation, the incidence of oral mucosa reaction was 56.90% in the experimental group, and 71.43% in the control group, the incidence of reaction on level 3, 4 in the control group(17.86%) was higher than that in the experimental group(6.90%); (3)The percentage of delayed radiotherapy in the control group(28.57%) was higher than that in the experimental group(15.52%); (4)The percentage of the patients who were treated with other interventional therapies in the control group(30.36%) was significantly higher than that in the experimental group(13.79%).Conclusion Zengyejiedu decoction can improve the patients′ radiation tolerance, release the acute oral mucosa reaction caused by radiation, and improve the quality of life. |
| Key words: Zengyejiedu decoction Head-neck malignant carcinoma Acute radioactive oral macositis |
