| 摘要: |
| ［摘要］ 目的 探讨他汀不同降脂强度对卒中后患者神经功能缺损、血脂水平、颈动脉内-中膜厚度的影响。方法 选取该院住院的脑梗死（卒中）患者68例，随机分为研究组和对照组各34例。在常规治疗基础上，研究组给予阿托伐他汀钙40 mg/次，1次/d，疗程3个月；对照组给予阿托伐他汀钙20 mg/次，1次/d，疗程3个月。分别于治疗前、治疗后3个月进行美国国立卫生研究院卒中量表（NIHSS）评分，收集血脂数据，应用彩色多普勒超声诊断仪检测颈动脉内-中膜厚度。结果 两组治疗前、治疗后3个月NIHSS评分比较差异无统计学意义（P>0.05）。治疗后，研究组总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）及颈动脉内-中膜厚度较对照组显著降低（P<0.05）；而甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）两组间未见显著差异。结论 相较于中强度的阿托伐他汀（20 mg），高强度的阿托伐他汀（40 mg）可显著降低TC及LDL-C水平，稳定颈内动脉斑块，减小颈动脉内-中膜厚度。 |
| 关键词: 降脂 卒中患者 神经功能缺损 血脂水平 颈动脉内-中膜厚度 |
| DOI：10.3969/j.issn.1674-3806.2018.05.17 |
| 分类号:R 743.3 |
| 基金项目: |
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| Effects of different lipid-decreasing intensities on poststroke nerve function defect, blood lipid level and intima-media thickness of carotid artery |
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WU Chuan-xi, LIN Jin-hua
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The Fourth Department of Internal Medicine, the Eighth People′s Hospital of Dongguan City, Guangdong 523000, China
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| Abstract: |
| ［Abstract］ Objective To explore the effects of different lipid-decreasing intensities on poststroke nerve function defect, blood lipid level and intima-media thickness of carotid artery.Methods 68 patients with acute cerebral infarction were randomly divided into the research group(n=34) and the control group(n=34). The research group was treated with atorvastatin calcium(40 mg, qd) for 3 months.The control group received calcium atorvastatin(20 mg, qd) for 3 months. NIHSS scores and the data of serum lipid level were collected before and after treatment. Intima-media thickness of carotid artery was detected by TCD method.Results There were no significant differences in NIHSS scores between the research group and the control group before and 3 months after treatment. After treatment, TC, LDL-C and the intima-media thickness of carotid artery in the research group were significantly lower than those in the control group. However, there were no significant differences in TG and HDL-C between the two groups.Conclusion Large dose of atorvastatin(40 mg) can decrease TC and LDL-C, stabilize internal carotid artery plaque, and reduce intima-media thickness of carotid artery on a larger scale than small dose of atorvastatin(20 mg). |
| Key words: Lipid-decreasing Stroke patients Nerve function defect Blood lipid level Intima-media thickness of carotid artery |
