| 摘要: |
| ［摘要］ 目的 分析血必净联合乌司他丁治疗重症急性胰腺炎的疗效及对血清炎症因子的影响。方法 选取该院2015-09～2016-04收治的重症急性胰腺炎患者70例作为研究对象，按照随机数字表法分为两组，各35例。对照组单纯采用乌司他丁治疗，观察组在乌司他丁治疗基础上加用血必净，均连续治疗7 d。对比两组治疗前后血清炎症因子水平、内毒素含量。结果 观察组痊愈18例，显效11例，有效4例，无效2例。对照组痊愈12例，显效10例，有效5例，无效8例。观察组疗效优于对照组(P<0.05)。治疗前两组患者血清炎症因子、内毒素含量比较差异无统计学意义（P>0.05）。治疗后，对照组患者超敏C反应蛋白（hs-CRP）、内毒素、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）水平均高于观察组，白细胞介素-10（IL-10）水平低于观察组，差异有统计学意义(P<0.01)。结论 血必净联合乌司他丁治疗重症急性胰腺炎临床疗效显著，可有效提高IL-10水平，降低内毒素、IL-6、IL-8、TNF-α水平，减轻炎症对患者造成的影响，值得在临床应用中推广。 |
| 关键词: 血必净 乌司他丁 重症急性胰腺炎 临床疗效 血清指标 |
| DOI：10.3969/j.issn.1674-3806.2018.06.23 |
| 分类号:R 576 |
| 基金项目: |
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| Effects of Xuebijing injection combined with ulinastatin on serum inflammatory factors in patients with severe acute pancreatitis |
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ZHANG Jie-xian
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Department of Digestive Internal Medicine, the First People′s Hospital of Zhumadian City, Henan 463000, China
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| Abstract: |
| ［Abstract］ Objective To analyze the effects of Xuebijing injection combined with ulinastatin on serum inflammatory factors in patients with severe acute pancreatitis. Methods 70 patients with severe acute pancreatitis in our hospital from September 2015 to April 2016 were selected as the research subjects and were divided into two groups by the random number table method, with 35 cases in each group. The control group received ulinastatin and the observation group was treated with ulinastatin plus Xuebijing injection. The serum levels of inflammatory cytokines and endotoxin were compared between the two groups before and 7days after treatment. Results In the observation group,18 cases were cured,11 cases markedly effective, 4 cases effective and 2 cases ineffective. In the control group,12 cases were cured,10 cases markedly effective, 5 cases effective and 8 cases inffective. The clinical effect of the observation group was significantly better than that of the control group(P<0.05). Before treatment,there were no significant differences in the levels of serum inflammatory cytokines and endotoxin between the two groups(P>0.05). After treatment, the levels of hs-CRP, endotoxin, IL-6, IL-8 and TNF alpha in the control group were significantly higher than those in the observation group, but the level of IL-10 in the control group was significantly lower than that in the observation group(P<0.01). Conclusion Xuebijing injection combined with ulinastatin is effective in the patients with severe acute pancreatitis, which can effectively elevate the level of IL-10 and reduce the levels of endotoxin, IL-6, IL-8 and TNF alpha. |
| Key words: Xuebijing injection Ulinastatin Severe acute pancreatitis Clinical curative effect Serum index |
