| 摘要: |
| ［摘要］ 药疹是常见的药物不良反应之一，其中一些严重的类型如Stevens-Johnson综合征（Stevens-Johnson syndrome,SJS）、中毒性表皮坏死松懈症（toxic epidermal necrolysis,TEN）、药物反应伴嗜酸性粒细胞增多和系统症状/药物超敏反应综合征（drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome,DRESS/DIHS）、急性泛发型发疹性脓疱病（acute generalized exanthematous pustulosis,AGEP）因累及多器官系统、后遗症多、致残致死率较高，被称为重症药疹。近年来，重症药疹与人类白细胞抗原（human leukocyte antigen,HLA）基因之间的关联性研究取得了重大进展，这些研究为未来建立预测个体潜在药疹遗传易感性的检测方法提供了基础。该文对重症药疹与特定HLA基因之间关系的研究概况进行综述。 |
| 关键词: 重症药疹 人类白细胞抗原 药物不良反应 |
| DOI：10.3969/j.issn.1674-3806.2018.06.29 |
| 分类号:R 758.25 |
| 基金项目: |
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| Advances in research on relationship between human leukocyte antigen and severe drug eruptions |
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XIANG Yi-kui, YAN Yan, WANG Bao-xi
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Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
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| Abstract: |
| ［Abstract］ Drug eruptions are the most common adverse reactions to drugs. Severe drug eruptions, including Stevens-Johnson syndrome(SJS), toxic epidermal necrolysis(TEN), drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome(DRESS/DIHS) and acute generalized exanthematous pustulosis(AGEP), can cause high mortality. Recently, substantial progress has been made in understanding the relationship between human leukocyte antigen(HLA) and severe drug eruptions. These findings will facilitate the establishment of testing methods for predicting potential genetic susceptibility to drug eruptions in individuals. In this paper, we review the relationship between severe drug eruptions and specific HLA alleles. |
| Key words: Severe drug eruptions Human leukocyte antigen Adverse drug reactions |
