| 摘要: |
| ［摘要］ 目的 探讨系统评价方法对小儿重症手足口病细胞免疫功能变化的可行性。方法 计算机检索CNKI、万方数据库、中国生物医学文献、维普、Cochrane图书馆、Medline、PubMed、web of science、Ovid等电子资料库，对手足口病患儿的细胞免疫功能进行比较。结果 共纳入42篇文献。（1）重症手足口病组CD4+细胞、CD8+细胞均低于普通手足口病组（P<0.05），重症手足口病组与普通手足口病组患儿CD4+细胞、CD8+细胞均较正常对照组降低（P<0.05）；（2）重症手足口病组B淋巴细胞较普通手足口病组增高（P<0.05），重症手足口病组与普通手足口病组患儿B淋巴细胞均较正常对照组增高（P<0.05）；（3）手足口病组的自然杀伤（NK）细胞与正常对照组比较差异均无统计学意义（P>0.05）。结论 手足口病患儿的T淋巴细胞功能处于抑制状态与手足口病的病情轻重相关联。 |
| 关键词: 手足口病 细胞免疫功能 儿童 |
| DOI：10.3969/j.issn.1674-3806.2018.07.08 |
| 分类号:R 816.92 |
| 基金项目:南宁市科学研究与技术开发计划项目（编号：20153092）；南宁市青秀区科技计划项目（编号：2015S06） |
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| Systematic review on changes of cellular immunity in severe hand-foot-mouth disease |
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LI Xing-zhi, WU Shu-yue, XIE Qing-ling
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Department of Pediatrics, the First People′s Hospital of Nanning City, Guangxi 530021, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the changes of cellular immunity in severe hand-foot-mouth disease(HFMD). Methods Databases including CNKI,VIP, CBM, WanFang Data, PubMed, Medline, Web of Science, Ovid and The Cochrane Library were searched to collect the data about the changes of cellular immunity in severe HFMD. The changes of cellular immunity in different stages were compared. Results A total of 42 literatures were included. (1)CD4+ cells and CD8+ cells in severe the HFMD group were significantly decreased than those in the common HFMD group(P<0.05); CD4+ and CD8+ cells in the severe group and the common group were significantly decreased than those in the health control group (P<0.05). (2) B lymphocyte in the severe group was significantly increased than that in the common group(P<0.05); B lymphocytes in the severe group and the common group were significantly increased than those in the health control group（P<0.05）. (3)There were no significant differences in NK cells between the HFMD group and the control group(P>0.05). Conclusion The function of T lymphocyte immunity in children with HFMD is in a state of inhibition which is related to the severity of the illness. |
| Key words: Hand-foot-mouth disease(HFMD) Cellular immunity Children |
