摘要: |
[摘要] 结外鼻型NK/T细胞淋巴瘤(extranodal NK/T cell lymphoma,nasal type,ENKTCL)是一种与EBV密切相关的恶性淋巴瘤,具有侵袭性强、对化疗反应差、易复发、预后差等特点。microRNA(miRNA)是一种约20~24 nt的非编码RNA,它的失调控可导致多种肿瘤的发生,与ENKTCL的发病密切相关。有效的分子指标对ENKTCL的正确诊断、及时治疗及预后评估具有重要意义。该文就miRNA在ENKTCL发生发展中的作用进行综述。 |
关键词: microRNA 淋巴瘤 结外鼻型NK/T细胞淋巴瘤 恶性肿瘤 |
DOI:10.3969/j.issn.1674-3806.2018.08.30 |
分类号:R 733 |
基金项目:国家自然科学基金资助项目(编号:81360355);广西卫计委科研课题(编号:Z2013355) |
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Research situation of the effect of microRNA on development of nasal type of extranodal NK/T-cell lymphoma |
CHEN Hui-ling, MO Xiang-lan
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Youjiang Medical College for Nationalities, Baise 533000, China
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Abstract: |
[Abstract] The nasal type of extranodal NK/T-cell lymphoma(ENKTCL) is a kind of malignant lymphomas closely associated with Epstein-Barr virus(EBV) infection. The features of ENKTCL are aggressive strongly, poor response to chemotherapy, easy to relapse and poor prognosis. microRNA(miRNA) is about 20~24 nt noncoding RNA, and the dysregulation of miRNA can lead to the occurrence of many tumors and is closely related to the pathogenesis of ENKTCL. Effective markers are crucial in the diagnosis, treatment and prognostic evaluation of ENKTCL. We review the roles of miRNA in the development of ENKTCL in this paper. |
Key words: microRNA(miRNA) Lymphoma Extranodal NK/T cell lymphoma, nasal type(ENKTCL) Malignancy |