| 摘要: |
| ［摘要］ 身高受遗传和环境因素共同影响，其中遗传因素对身高的影响更大。身高遗传学的基因研究，从家系单基因连锁分析到复杂疾病/性状的候选基因关联分析、全基因组关联研究，每一阶段都取得了重大成果。目前，已发现并鉴定了数百个与身高相关的遗传位点，解释了身高遗传的部分机制，但大部分相关基因位点对身高稳定精确的作用机制尚不明了，表明身高受多基因的复杂调控。该文就身高的遗传学研究概况作一综述。 |
| 关键词: 身高 遗传学 连锁分析 候选基因 全基因组关联研究 |
| DOI：10.3969/j.issn.1674-3806.2018.11.28 |
| 分类号:R 394 |
| 基金项目: |
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| Research progress of genetics of height |
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SONG Hong-chao, LIANG You-fang
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Department of Preventive Health Care, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Height is influenced by genetic and environmental factors. Medical studies have confirmed that genetic factors have a greater impact on height development. The genetic research of height genetics has gone through family single gene linkage analysis to candidate gene association analysis of complex diseases/traits and genome-wide association study. Great achievements have been achieved in every stage of research. So far, hundreds of genetic sites associated with height have been found and identified, which explains part of the mechanism of height genetics. The mechanisms of the stability and accuracy of most of the related gene loci remain unknown. These indicate that height is a complex trait controlled by multiple genes. In this paper, a summary of the genetic research of height is reviewed. |
| Key words: Height Genetics Linkage analysis Candidate gene Genome-wide association study |
