| 摘要: |
| ［摘要］ 目的 探讨参芪益心汤治疗射血分数正常慢性充血性心力衰竭的作用。方法 选择确诊的射血分数正常慢性充血性心力衰竭患者94例，将患者随机分为中医组和西医组，各47例。中医组给予中药参芪益心汤治疗，西医组给予硝酸甘油、利尿剂、血管紧张素转化酶抑制剂（ACEI）等治疗，治疗4周为1个疗程，治疗3个疗程。比较两组治疗期间以及治疗后的左室功能指标、N末端B型利钠肽原（NT-proBNP）血浆水平变化以及临床疗效。结果 两组治疗后左室射血分数（LVEF）、高峰射血率（PER）明显高于治疗前，高峰射血时间（TPER）明显低于治疗前（P<0.05），中医组LVEF、PER明显高于西医组，TPER比西医组明显缩短(P<0.05)。两组治疗前血浆NT-proBNP水平无明显差异，治疗后均明显降低（P<0.05），但中医组明显低于西医组(P<0.05)。中医组显效26例，有效18例，无效3例。西医组显效17例，有效21例，无效9例，中医组疗效优于西医组(P<0.05)。结论 参芪益心汤加减治疗射血分数正常慢性充血性心力衰竭能有效改善患者心功能，增加其活动耐受力，疗效优于西药治疗。 |
| 关键词: 参芪益心汤 左室射血分数 慢性充血性心力衰竭 |
| DOI：10.3969/j.issn.1674-3806.2019.01.18 |
| 分类号:R 541.6 |
| 基金项目: |
|
| Clinical observation of Shenqiyixin decoction on chronic congestive heart failure in patients with normal ejection fraction |
|
LIU Jing-mei, LI Yu-xian
|
|
Department of Heart Diseases, the Second Traditional Chinese Medicine Hospital of Luoyang City, Henan 471003, China
|
| Abstract: |
| ［Abstract］ Objective To investigate the effect of Shenqiyixin decoction on chronic congestive heart failure in patients with normal ejection fraction. Methods Ninety-four patients who were diagnosed with chronic congestive heart failure but with normal ejection fraction were selected, and were randomly divided into Chinese Medicine group and Western Medicine group, with 47 cases in each group. The Chinese Medicine group was treated with Traditional Chinese Medicine Shenqiyixin decoction. The Western Medicine group was treated with nitroglycerin, diuretic and angiotensin-converfing enzyme inhibitor(ACEI), with 4 weeks for a course and a total of 3 courses of treatment. The changes of clinical indexes of left ventricular function and plasma NT-proBNP levels during and after treatment, and the curative effect were compared between the two groups. Results The levels of LVEF, PEF after treatment were obviously higher than those before treatment in the two group, while the levels of TPER were obviously lower than those before treatment(P<0.05). The levels of LVEF and PEF were obviously higher and the level of TPER was obviously shorter in the Chinese Medicine group than those in the Western Medicine group(P<0.05). There were no significant differences in the plasma levels of NT-proBNP between the two groups before treatment, but they were significantly reduced in both of the two groups after treatment(P<0.05). The improvement of NT-proBNP in the Chinese Medicine group was better than that in the Western Medicine group(P<0.05). In the Chinese Medicine group, 26 cases were markedly effective, 18 cases effective and 3 cases ineffective. In the Western Medicine group, 17 cases were markedly effective, 21 cases effective and 9 cases ineffective. The curative effect of the Chinese Medicine group was better than that of the Western Medicine group(P<0.05). Conclusion Modified Shenqiyixin decoction is effective on chronic congestive heart failure and improves cardiac function and increases activity tolerance in the patients who are diagnosed with chronic congestive heart failure but with normal ejection fraction. |
| Key words: Shenqiyixin decoction Left ventricular ejection fraction(LVEF) Chronic congestive heart failure |
