引用本文:周晓萍,张玲,吴君荣.探讨原发性肝癌患者症状体征与血清AFP的关系[J].中国临床新医学,0,():-.
周晓萍,张玲,吴君荣.探讨原发性肝癌患者症状体征与血清AFP的关系[J].中国临床新医学,0,():-.
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探讨原发性肝癌患者症状体征与血清AFP的关系
周晓萍1, 张玲2, 吴君荣3
1.广西中医药大学第一附属医院;2.广西中医药大学附属瑞康医院;3.广西医科大学附属肿瘤医院
摘要:
[摘要]目的 分层研究血清AFP水平与原发性肝癌(PHC)患者各临床症状和体征的相关性。方法 采用SPSS 19.0软件统计分析PHC患者不同层次血清AFP水平中的各临床症状和体征。结果 本研究共纳入1030例PHC患者，logistic回归分析发现，年龄、腹痛、腹胀、影像学检查为块状型、病理检查为肝细胞型及胆管细胞型对血清AFP水平有明显影响。通过线性趋势分析发现肝硬化、腹痛、腹胀、腹水、肝大、影像学检查为块状型、大三阳及小三阳百分率随AFP水平的升高而呈现增加趋势，而影像学检查为结节型、病理检查为肝细胞型和胆管细胞型阳性百分率随AFP水平的升高而呈现下降趋势。结论 临床上应动态监测PHC患者血清AFP水平，并密切观察患者症状和体征的变化，更好的提高PHC患者的治疗效果。
关键词:  甲胎蛋白  原发性肝癌  症状  体征
DOI：
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基金项目:广西高校中青年教师基础能力提升项目（编号：2017KY0127）
Explored the relationship between symptoms, signs and serum Alpha-fetoprotein level of patients with primary hepatocellular carcinoma
周晓萍,张玲,吴君荣
Abstract:
Explored the relationship between symptoms, signs and serum Alpha-fetoprotein level of patients with primary hepatocellular carcinoma Zhou Xiao-ping﹡, Zhang Ling, Wu Jun-rong. ﹡Department of Laboratory Medicine, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530022, Guangxi, China. [Abstract] Objective To explore the relationship between symptoms, signs and different Alpha-fetoprotein (AFP) levels of patients with primary hepatocellular carcinoma (PHC). Methods SPSS 19.0 was used to statistically analyze symptoms and signs of PHC patients with different levels of AFP. Results A total of 1030 PHC patients were included in our study. The results from the logistic regression analysis showed that the following factors had a significant effect on AFP levels, including age, abdominal pain, bloating, block type, type of liver cells, bile duct cell type. The results from the linear trend analysis indicated that the percentage of positive cirrhosis, abdominal pain, bloating, ascites, hepatomegaly, massive, HBsAg, HBeAg and Anti-HBc positive and HBsAg, Anti-HBe and Anti-HBc positive increase with elevated AFP, while the percentage of positive nodular, type of liver cells and bile duct cell type decrease with elevated AFP. Conclusions In order to make PHC patients are treated more timely and effectively, we should dynamically detect serum AFP level and observe the clinical symptoms and signs of PHC patients [Key words] Alpha-fetoprotein, Primary hepatocellular carcinoma, Symptom, Sign
Key words:  Alpha-fetoprotein, Primary hepatocellular carcinoma, Symptom, Sign