摘要: |
目的 探讨奥卡西平联合丙戊酸钠治疗对青年难治性部分性癫痫(refractory partial epilepsy,RPE)患者认知功能的影响。方法 选取2016-01~2016-12收治的100例青年RPE患者为研究对象,按照随机数字表法将其分为对照组和观察组,每组50例。对照组给予丙戊酸钠治疗,观察组在对照组的基础上给予奥卡西平治疗,连续治疗6个月,比较两组临床疗效、癫痫发作频率、认知功能评分及临床不良反应。结果 观察组临床治疗总有效率(92.00%)明显高于对照组(68.00%),且差异有统计学意义(P<0.05);观察组和对照组临床不良反应发生率均较低,分别为8.00%和6.00%,两组比较无明显差异(P>0.05);两组治疗后3个月及6个月的癫痫发作频率明显低于同组治疗前水平(P<0.05),且观察组低于对照组(P<0.05);两组治疗后3个月及6个月的MoCA评分明显高于同组治疗前水平(P<0.05),且观察组高于对照组(P<0.05)。结论 奥卡西平联合丙戊酸钠治疗青年难治性部分性癫痫的疗效确切,可明显改善患者的认知功能,降低癫痫发作频率,且临床安全性较好,值得推广应用。 |
关键词: 奥卡西平 丙戊酸钠 难治性部分性癫痫 临床疗效 认知功能 |
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Effects of oxcarbazepine combined with sodium valproate on cognitive function in patients with chronic refractory partial epilepsy |
Ye Zhanghai
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Department of neurology,The second people's hospital of Zhaoqing city,Guangdong province
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Abstract: |
Objective To investigate the effect of oxcarbazepine combined with sodium valproate on cognitive function in patients with chronic refractory partial epilepsy.Methods A total of 100 young patients with RPE were enrolled in our hospital fromJanuary 2016 to December 2016. They were divided into control group and observation group according to the random number table method. Fifty patients in each group were divided into control group and observation group.The control group was treated with sodium valproate. The observation group was treated with oxcarbazepine on the basis of the control group for 6 months. The clinical efficacy, seizure frequency, cognitive function score and clinical adverse reaction were compared between the two groups.Results The overall effective rate (90.00%) was significantly higher in the observation group than in the control group (76.00%), and the difference was statistically significant (P<0.05). The incidence of clinical adverse reactions in the observation group and the control group were lower(P<0.05). The frequency of seizures at three months and six months after treatment was significantly lower than that of the same group (P<0.05), and the level of epilepsy was significantly lower in the two groups (P> 0.05) . The scores of MoCA at three months and six months after treatment were significantly higher than those of the control group (P <0.05), and the observation group was higher than the control group (P<0.05).Conclusions Oxacillipine combined with sodium valproate in the treatment of chronic refractory partial epilepsy is effective, can significantly improve the cognitive function of patients, reduce the frequency of seizures, and clinical safety is good, worthy of popularization and application. |
Key words: Oxcarbazepine Sodium valproate Refractory partial epilepsy Clinical efficacy Cognitive function |