引用本文: | 刘怀毫,魏波,梁振,梁沛杰,陈祝明.骨肉瘤化学治疗进展[J].中国临床新医学,0,():-. |
| liuhuaihao,weibo,liangzhen,liangpeijie,chenzhuming.骨肉瘤化学治疗进展[J].中国临床新医学,0,():-. |
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摘要: |
骨肉瘤(Osteosarcoma, OS)是临床骨科肿瘤中发病率最高的原发于骨组织恶性骨肿瘤,主要好发于儿童。骨肉瘤治疗总体难度较大,随着新辅助化疗和术后辅助化疗的出现,患者无病生存率和预后较前获得了较大的改善。然而骨肉瘤化疗的毒副作用,包括骨髓拟制反应、恶心、呕吐、脱发,粘膜炎症、生育能力的丧失及偶发过敏反应给患者带来一定的生理和心理上的伤害。同时骨肉瘤对化学药物的抵抗及耐药骨肉瘤细胞的出现,使得骨肉瘤的对当前化疗方案效果不太理想。本文针对骨肉瘤的化学治疗进行综述,进一步说明骨肉瘤化疗现状及其进展。 |
关键词: 骨肉瘤 化疗 耐药性 毒副作用 |
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基金项目:2017年度广东大学生科技创新培育专项资金(编号:pdjh2017a0219) |
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Progress in osteosarcoma chemotherapy |
liuhuaihao, weibo, liangzhen, liangpeijie, chenzhuming
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Affiliated Hospital of Guangdong Medical University
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Abstract: |
Osteosarcoma is the most common malignant bone tumor of bone in clinical orthopedic tumors. It is derived from mesenchymal tissue and mainly consists of spindle fibroblasts and osteoblasts, which are mainly good Made in children. The overall treatment of osteosarcoma is more difficult. With the advent of neoadjuvant chemotherapy and postoperative adjuvant chemotherapy, disease-free survival rate and prognosis have been greatly improved . However, the side effects of osteosarcoma chemotherapy, including myelosuppression, nausea, vomiting, hair loss, mucosal inflammation, loss of fertility and incidental allergic reactions, have caused physical and psychological damage to patients. Simultaneously, Osteosarcoma resistance to chemical drugs and the emergence of resistant osteosarcoma cells make osteosarcoma less effective than current chemotherapy regimens. This review summarizes the chemotherapy of osteosarcoma to further illustrate the status and progress of osteosarcoma chemotherapy. |
Key words: Osteosarcoma Chemotherapy Prognosis side effects Drug resistance |