| 摘要: |
| 目的 探讨慢性阻塞性肺疾病(COPD)合并侵袭性肺曲霉菌病(IPA)的危险因素。方法 采用病例对照研究的方法，选取2015.5-2018.5我院呼吸内科住院的COPD合并侵袭性肺曲霉菌病的住院患者共24例为观察组，以年龄为匹配因素(±2岁)， 1:2的比例选取同期住院的COPD患者共48例为对照组，采用条件logistic回归分析COPD合并侵袭性肺曲霉菌病的危险因素。结果 单因素分析结果显示COPD频繁急性加重、糖尿病、慢性肾功能不全、应用广谱抗生素≥2周、应用糖皮质激素为COPD合并侵袭性肺曲霉菌的危险因素(P＜0.10)；采用条件logistic分析，糖尿病、应用广谱抗生素≥2周、应用糖皮质激素为COPD合并侵袭性肺曲霉菌病的独立危险因素(OR=7.384,6.681,32.354,P ＜0. 05)。结论 糖尿病、应用糖皮质激素为COPD合并侵袭性肺曲霉菌病的独立危险因素。 |
| 关键词: 慢性阻塞性肺疾病，侵袭性肺曲霉菌病，危险因素 |
| DOI： |
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| Rrisk factors of chronic obstructive pulmonary disease combined with invasive pulmonary aspergillosis |
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An Yongpeng
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Kaifeng Central Hospital
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| Abstract: |
| Objective To investigate the clinical risk factors of chronic obstructive pulmonary disease combined with invasive pulmonary aspergillosis. Methods This case control study include patients with COPD in Department of Resp-iratory Medicine，Kaifeng Central Hospital from May 2015 to May 2018,Twenty-four cases of IPA patients with COPD were matched(age,±2years) with fourty-eight control patients with COPD. We evaluated risk factors of IPA in COPD patients with conditional logistic regression analysis.Results Singal factor analysis showed that significant factors were acute exaxerbation of COPD,diabetes mellitus ,chronic renal failure,duration of broad-spectrum antibiotic use≥ two weeks and systemic use of steroids (P＜0.10);Conditional logistic regression analysis showed that diabetes mellitus and systemic use of steroids were the independent risk factors of COPD combined with invasive pulmonary aspergillosis (OR=7.384,6.681,32.354,P ＜0. 05). Conclusions Diabetes mellitus,duration of broad-spectrum antibiotic use≥ two weeks and systemic use of steroids are independent risk factors of COPD combined with conditional logistic regression analysis invasive pulmonary aspergillosis. |
| Key words: chronic obstructive pulmonary disease, invasive pulmonary aspergillosis, risk factor |
