引用本文: | 莫柱宁,焦伟,罗瑞献,阳子骥,黎海澜,叶冬梅.哌拉西林他唑巴坦钠诱导免疫性溶血反应的研究[J].中国临床新医学,0,():-. |
| mo zhu ning,Jiao Wei.哌拉西林他唑巴坦钠诱导免疫性溶血反应的研究[J].中国临床新医学,0,():-. |
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摘要: |
目的 探讨哌拉西林他唑巴坦钠药物抗体的发生频率及其导致免疫性溶血反应的情况。方法 应用微柱凝胶技术对临床上使用哌拉西林他唑巴坦钠治疗的患者,采集血样进行直接抗球蛋白试验(DAT),并对DAT阳性者进行哌拉西林他唑巴坦钠药物抗体检测,对药物抗体阳性者收集实验室数据及临床资料,分析其诱导免疫溶血反应的情况。结果 纳入本研究的125例被检者中,DAT阳性74例(59.2%),其中检出哌拉西林他唑巴坦钠药物抗体34例(27.2%),发现4例患者出现症状较轻的血管外溶血反应。结论 临床上使用哌拉西林他唑巴坦钠治疗过程中,机体可产生相关药物抗体而引起药源性免疫溶血反应。 |
关键词: 抗菌药物,药物抗体,免疫溶血 |
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基金项目:基金项目:广西科学研究与技术开发计划课题(桂科攻14279011)、广西卫生和计划生育委员会科研课题(Z20170315) |
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The study of piperacillin tazobactam sodium-induced immune hemolytic reaction |
mo zhu ning, Jiao Wei
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The People’s Hospital of Guangxi Zhuang Autonomous Region
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Abstract: |
Objective To explore the prevalence of piperacillin tazobactam sodium antibodies and the characteristics of these drug-induced immune hemolytic reaction. Methods We collected blood samples from patients who treated with piperacillin tazobactam sodium, using the red blood cell to do the direct antiglobulin test (DAT) by the micro gel column technique. When the DAT was positive, subsequent drug antibodies detection was performed. Then collecting the laboratory and clinical data of patients with drug antibodies to analyze whether they suffered a drug antibodies-induced immune hemolysis reaction. Results In total,125 patients were entered into this study. Among them, there were 74 patients (59.2%) with DAT positive and 34 patients(27.2%)with piperacillin-tazobactam sodium drug antibodies. Of these patients with drug antibodies, only four patients encountered extravascular hemolysis with slight symptoms. Conclusion Patients who treated with piperacillin tazobactam sodium would produce drug antibodies and cause drug-induced immune hemolytic reaction. |
Key words: Antibiotics Drug antibody Immune hemolytic reaction |