引用本文: | 朱慧静,朱昕,沙晗,张巧芹,程霖,杨明明.妊娠期糖尿病患者血清vaspin的变化及其与炎症因子的关系[J].中国临床新医学,0,():-. |
| 朱慧静.妊娠期糖尿病患者血清vaspin的变化及其与炎症因子的关系[J].中国临床新医学,0,():-. |
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摘要: |
目的 探讨妊娠期糖尿病(GDM)患者血清vaspin水平的变化及其与炎症因子TNF-α、IL-6的相关性。 方法 选取2016年10月至2017年12月于菏泽市立医院产科门诊行常规产前检查的孕妇120例,按75g葡萄糖耐量试验(OGTT)结果,分为GDM组60例,糖耐量正常妊娠组(GNGT)60例,采用酶联免疫吸附法(ELISA)测定空腹血清vaspin、TNF-α、IL-6水平。采用SPSS 22.0软件进行统计学分析。依据数据类型,分别进行t检验、Pearson线性相关分析及多元逐步回归分析。 结果 GDM组血清vaspin、TNF-α、IL-6水平均显著高于GNGT组(P<0.05)。线性相关分析显示,Vaspin与孕前BMI(r=0.328, P<0.01)、BMI增加幅度(r=0.21, P=0.021)、FINS(r=0.269, P=0.003)、HOMA-IR(r=0.26, P=0.004)呈正相关,与TNF-α(r=-0.205, P=0.025)、IL-6(r=-0.193, P=0.035)呈负相关。多因素回归分析显示,孕前BMI、TNF-α、IL-6和HOMA-IR是血清vaspin的独立影响因素(P<0.05)。 结论 GDM患者血清vaspin、TNF-α、IL-6水平均升高,vaspin可能代偿性参与了肥胖、胰岛素抵抗及GDM的发生发展。同时Vaspin有抑制炎症反应的作用。 |
关键词: vaspin 妊娠期糖尿病 TNF-α IL-6 胰岛素抵抗 |
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Change of serum vaspin levels in patients with gestational diabetes mellitus and its correlation with inflammatory factors ZHU Hui-jing,ZHU Xin, SHA Han, et al. Department of Endocrinology Metabolism, Municipal Hospital, Heze, Shandong 274031, China.Corresponding author:YANG Ming-ming,E-mail:fancycarp158@163.com |
朱慧静
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Municipal Hospital of HeZe
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Abstract: |
Objective To explore the change of serum vaspin levels in patients with gestational diabetes mellitus (GDM) and its correlation with inflammatory factors TNF-α、IL-6. Methods 120 cases of pregnant women undergoing prenatal examination in obstetrical clinic of HeZe Municipal Hospital from October 2016 to December 2017 were selected and given 75g oral glucose tolerance test (OGTT), based on which the 120 pregnant women were divided into GDM group(n=60) and normal glucose tolerance(GNGT)group(n=60).The level of fasting serum vaspin, TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay(ELISA).For the statistical analysis by SPSS 22.0 software. According to data type, t-test, Pearson linear correlation analysis and multivariate regression are performed separately. Results The serum vaspin, TNF-α and IL-6 in GDM group were significantly higher than that of GNGT group (P<0.05).Correlation analysis showed that vaspin was positively correlated with pre-gestational BMI(r=0.328, P<0.01),increment of BMI during pregnancy(r=0.21, P=0.021),FINS(r=0.269, P=0.003) and HOMA-IR(r=0.26, P=0.004); while negatively correlated with TNF-α(r=-0.205, P=0.025) and IL-6(r=-0.193, P=0.035).In a multiple stepwise linear regression analysis,pre-gestational BMI, TNF-α, IL-6 and HOMA-IR were independent determinants for serum vaspin concentrations. Conclusion Serum vaspin, TNF-α and IL-6 levels in GDM subjects are increased; vaspin may be compensatory in the occurrence and development of obesity, IR and GDM. Meanwhile vaspin can inhibit the inflammatory response. |
Key words: Vaspin Gestational diabetes mellitus TNF-α IL-6 Insulin resistance |