［Abstract］　Objective　To evaluate the diagnosis, clinical features and treatment of deformity of meatal-hymen.Methods　 Fifteen cases of deformity of meatal-hymen in our department from Dec.1998 to Dec.2006 were reviewed and analyzed.Results　 All patients were treated with surgical methods and had been followed up for 3～36 months. The curative and effective rate of surgical therapy was 86.7% and 100.0%, respectively.Conclusion　Deformity of meatal-hymen should be taken into consideration in females patients with repeated lower urinary tract infection. Surgical intervention is recommended if the diagnosis has been confirmed.]]> 2018/12/13 9:30:20 TANG Yong, WANG Zhi-rou, MENG Qing-gui, et al. 642true ［Abstract］　Objective　To observe the relations of renal function in type 2 diabetes patients and related factors to explore the risk factors of renal dysfunction. Methods　A total of 492 cases were recruited from the department of endocrinology in our study. Their clinical data were collected and biochemical indicators were measured. The data were analyzed by SPSS13.0 software. Results　Age, course, systolic blood pressure, total cholesterol, low-density lipoprotein, blood urea nitrogen, serum creatinine, serum uric acid and urinary albumin excretion in type 2 diabetes with renal dysfunction group were significantly higher than the normal renal function group (P<0.05). They were relevant with age, course and urinary albumin excretion (P<0.05). Conclusion　Age and course is the main influencing factors of renal dysfunction in type 2 diabetes patients.]]> 2018/12/13 9:30:20 HU Ying-yu, YAN Xiao-dong, LU Wen-sheng, et al. 641true ［Abstract］　Objective　To discuss the adaptation of conservative therapy and surgery treatment of lumbar spinal stenosis in elder patients.Methods　The analysed elder patients of lumbar spinal stenosis were divided into 2 groups.Fifty-four cases in the surgery group were performed surgery treatment one week after diagnosis and performed the waist muscle function exercise after one week of surgery treatment. Forty-two cases in the conservative therapy group were treated by such conservative treatments as bed rest, the non-hormone pharmacological treatment, the physical therapy, the silver nature needle treatment, the waist muscle exercise, the massage as well as the waistband to protect the waist.Results　The cure rate in surgery group was 94.2%, that in conservative therapy group was 90.5%. There were no significant difference between two groups (P>0.05).Conclusion　All lumbar spinal stenosis in elder patients needs the surgery by no means and should grasp strictly the adaptation between conservative therapy and surgery treatment.]]> 2018/12/13 9:30:20 LAN Yong-bo 640true ［Abstract］　Objective　To explore the relationship between the brachial ankle pulse wave velocity （Ba-PWV）level and high risk factors of coronary heart disease and stricture of coronary artery in acute coronary syndrome(ACS).Methods　Seventy four cases of ACS were divided into two groups: twenty cases with Ba-PWV<1400cm/s and fifty four cases with Ba-PWV>1400 cm/s. Risk factors of coronary heart disease were analyzed such as age, gender, hypertension, hyperlipidemia, diabetes mellitus and smoking and stricture of coronary artery in two groups. Results　(1)In group with Ba-PWV>1400cm/s, the risk factors of coronary heart disease was more than that in group with Ba-PWV<1400cm/s, P<0.05, the risk factors were no less than two in 96.3% of cases, P<0.01.(2)There was no statistics difference in the stricture degree of coronary artery between two groups.Conclusion　The risk factors in the cases with high Ba-PWV levels are more than those in the cases with low Ba-PWV level in ACS. There was no relativity between the Ba-PWV and the stricture degree of corresponding coronary arteries in ACS.]]> 2018/12/13 9:30:20 ZHANG Xiao-dong, LI yi, LI Jian-mei, et al. 639true ［Abstract］　Objective　To observe the effect of different dose simvastatin on carotid intimamedia thickness(IMT) of ischemic cerebrovascular disease patients and the safety of medication.Methods　One hundred and eighty-six ischemic cerebrovascular disease patients were randomly divided into 10 mg/d、20 mg/d、30 mg/d、40 mg/d four simvastastin treatment group. All patients were examined the carotid intimamedia thickness before treatment and after six months treatment, then compared the variability of the carotid IMT within group and between groups, and compared untoward reaction of medication between groups.Results　After 6 months treatment, every comparisions and corresponding t-values were as follows: the carotid IMT of every group compared with before treatment, P<0.05； the carotid IMT of 10mg/d group compared with other three groups, P<0.05; the carotid IMT of 20 mg/d group compared with 30 mg/d group, P>0.05；the carotid IMT of 20mg/d group compared with 40 mg/d group, P<0.05；the rate of untoward reaction of 10 mg/d group compared with 20 mg/d group, P>0.05; the rate of untoward reaction of 10mg/d group and 20mg/d group compared with other two groups, P<0.05.Conclusion　Four groups simvastatin treatment can degrade carotid IMT, 20mg/d group can degrade carotid IMT effectually, but also avoid high rate of untoward reaction of medication.]]> 2018/11/7 8:23:04 HONG Xing 638true ［Abstract］　Objective　To study the feasibility of the application of DiaMed add clone gelatin card in identifying ABO and Rh(D) of newborn′s navel blood and direct coombs′ test. Methods　Navel blood were samplied. In identifying ABO and Rh(D) were used DiaMed odd clone gelatin cards and test tube method and direct coombs′ test. Results　The results of identifying blood type and identifying Rh(D) were all identical between DiaMed odd clone gelatin cards and test tube method and in direct coombs′ test, the checked ratio of test tube method was 4.04% and the DiaMed odd clone gelatin cards′ was 5.05%. Conclusion　DiaMed odd clone gelatin cards is better than test tube method in direct coombs′ test， and the identifying results of ABO and Rh(D) are reliable. It could have a good use in identifying newborn′s blood type and in direct coombs′ test.]]> 2018/11/7 8:23:04 JIAO Wei, LI Hai-lan 637true ［Abstract］　Objective　To summarize the therapeutic efficacy and experience of pneumocystoscopic Cohen ureteric reimplantation in children.Methods　During April 2006 to October 2008, 14 children with monstrositas in the distal ureter were treated with pneumocystoscopic Cohen ureteric reimplantation. In these cases, age ranged from 6 months to 12 years, 8 cases suffered from vesicoureteral reflux, 5 cases with vesicoureteral junction obstruction and 1 case with ureterocele. The comparision between the group of cases used pneumocystoscopic Cohen ureteric reimplantation and the group of 42 cases used open Cohen′s procedure included age, blood loss, post-operation hospital stay, complication and therapeutic efficacy.Results　All procedures were accomplished without conversion. The mean operative age was (5.1±4.2) years and the duration of operation was (128.9±52.1) minutes which were coincidence to the open procedure(P>0.05); blood loss was (4.7±1.3)ml, lower than open procedure(P<0.05), the post-operation hospital stay was (6.9±2.4) days, lower than open procedure. All the cases had no complication, none of them had obstruction of ureter and vesicoureteral reflux in the 0.5～1 year follow-up period, which were coincidenced to the open procedure(P>0.05).Conclusion　Pneumocystoscopic Cohen ureteric reimplantation as a well minimally invasive surgery, which is safe and reliable in children with monstrositas in the distal ureter.]]> 2018/11/7 8:23:04 DONG Chun-qiang 636true ［Abstract］　Objective　To study the application of the standardized patient in health evaluation teaching of higher nursing professional education.Methods　One hundred and twenty-two students in 2 classes of 2006-grade of nurising profession and Four hundred and eighty-three students in 9 classes of 2007-grade of nurising profession in the Guangxi Medical Managment College were chosen as the objects of study, and after end of course the statistic comparative analysis of the results and the questionnaire survey were separately performed.Results　In comparison of the experimental group and the control group, There was no significant correlation between the two groups′s score on health evaluation test (P>0.05), but there was significant correlation between two groups′s score on writing of holistic nursing casehistory test (P<0.05). The most of students obtained the positive attitude to the effects of standardized patient in health evaluation teaching.Conclusion　Application of the standardized patient in the teaching can obviously enhance the students′ ability to interrogate the healthy history.This practice will not only push forward quality-oriented education, but also upgrade health evaluation teaching and learning in China.]]> 2018/11/7 8:23:04 LIU Chun-bin, XIE Xiao-keng, LIANG Hui-ping 635true ［Abstract］　Objective　To discuss the effect of health education in treating atopic dermatitis, in order to providing the basis for improving atopic dermatitis. Methods　Ninety-one 1-year-old patients with atopic dermatitis were divided into 2 groups including experimental and reference group which are given conventional treatment, and experimental group was added to be intervened with health education, tracking the two group patients for two years and then evaluating the effect of treatment.Results　（1）Total treatment efficiency of 2-year-old experimental group was 57.14% which had no significant difference compared with reference group whose total treatment efficiency was 50%(P>0.05). （2）Total treatment efficiency of 3-year-old experimental group was 83.78% which higher significantly than reference group whose total treatment efficiency was 58.82%(P<0.05).（3）Total treatment efficiency had significant difference between 2-year-old and 3-year-old experimental groups(P<0.05), however, there was no significant difference when compared with corresponding two reference groups(P>0.05).Conclusion　Carrying out continuous health education to atopic dermatitis patients can help to improve treatment.]]> 2018/12/3 0:00:00 LU Hai, LI Jian-min, WANG Juan, et al. 634true ［Abstract］　Objective　To observe the clinical efficacy of multipurpose spectrum instrument in the treatment of cervical erosion.Methods　Four hundred and eighteen patients with cervical erosion were treated by multipurpose spectrum instrunent, and followed-up for two month after treatment for observing the curative effect and side-effect.Results　The total cure rate was 97.6%；the cure rates in mild degree(Ⅰ), moderate degree(Ⅱ), and severe degree(Ⅲ) growp were 100%，97.4% and 95.2%，respectively; no severe complication occurred.Conclusion　Using multipurpose spectrum instrument in the treatment of cervical erosion has many advantages, such as shorter course of treatment, higher curative effect, satety and reliability etc. It should be widely used in clinic.]]> 2018/12/3 8:39:12 HUANG Jiang-lian, ZHOU Hui-hong, ZHOU Gui-fen, et al. 633true ［Abstract］　Objective　To study reasonable body weight gain of pregnant women in normal pregnancy in Guilin area.Methods　The data of 238 of pregnant women in Affiliated Hospital of Guilin Medical College for antenatal care and information informed choice were collected, the pre-pregnancy maternal weight, height, prenatal weight and neonatal birth weight in the single fetal primipara were recorded.Results　(1)The best data from 222 pregnant women showed that all pregnant women increased by an average weight of 14.37 kg;(2)There was no significant statistical difference between maternal weight gain during pregnancy and birth weight;(3)There was no significant statistical difference between different pre-pregnancy body mass index (BMI) and birth weight.Conclusion　In Guilin area, the recommended weight gain for pregnant women in the BMI value of different groups was 14 kg.]]> 2018/12/3 8:39:12 ZHONG Ping, YAO Jun, Yang hua 632true ［Abstract］　Objective　The diagnosis of Churg-Srauss syndrome (CSS) keeps difficult during clinical practice. To enhance the knowledge of CSS, 5 cases of this disorder were reported.Methods　The clinical data of 5 patients with CSS were analyzed and related literatures were reviewed.Results　At the time of diagnosis, all of the 5 patients with CSS presented with asthma, rhinitis or paranasal sinusitis was found in 3 patients, heart and gastrointestinal tract were involved in 1 patient, respectively. Five patients had eosinophilia of >10% white blood cell. The major radiographic findings showed pulmonary infiltrates in 5 patients, which were transient patterns in 3 patients. All patients achieved remission by corticosteroid or combination with immunosuppressant.Conclusion　Asthma, peripheral blood eosinophilia and migratory pulmonary consolidation are the clinical features of CSS. Corticosteroid or immunosuppressant adjunction to corticosteroid benefits this disease.]]> 2018/12/3 8:39:12 QIN Zhi-qiang, WEI Hai-ming, LU Ai-ling, et al. 631true ［Abstract］　Objective　To discussion the endoscopic thyroidectomy main points, feasibility and clinical value of the endoscopic thyroidectomy.Methods　Thirty-eight thyroid adenoma patients were analyzed by retrospective analysis method，the patients were randomly divided into endoscopic thyroidectomy group(observation group) and the traditional thyroidectomy group (control group).Results　All patients were successfully completed surgery, postoperative recovery was good, no postoperative complications such as breathing difficulties occurred. Bleeding volume, duration of hospitalization, pain score, beauty cosmetic evaluation of observation group were better than these of the control group, the difference between the groups was significant （P<0.05）.Conclusion　Endoscopic thyroidectomy can not only achieve minimally invasive surgery purpose，but also have advantages.Such as less bleeding, less postoperative pain, shorter hospitalization time, it is a safe and effective method for treatment of thyroid diseases.]]> 2018/12/3 8:39:12 WANG Hai-peng, TIAN Xiao-lin, PANG Ling-kun 630true ［Abstract］　Objective　To analysies the cost-effectiveness on statins in the treatment of type 2 diabetes patients with hyperlipoidemia and find out a low-cost and effective treatment scheme. Methods　One hundred and sixty-eight type 2 diabetes patients with hyperlipoidemia were randomly divided into 4 groups, Group A received fluvastatin, Group B received lovastatin, Group C received provastatin and Group D received simvastatin. The therapeutic effects and cost-effectiveness were compared in 4 groups.Results　The effective rates of Groups A, B, C and D were 85.71%、88.10%、83.33%、90.48%, respectively(P>0.05), the cost-effectiveness ratios were 166.58、95.77、163.16、84.90 respectively.Conclusion　Simvastatin is the optimal treatment for type 2 diabetes patients with hyperlipoidemia.]]> 2018/12/3 8:39:12 WANG You-hong 629true ［Abstract］　Objective　To investigate the therapeutic effects of combivent and mucovent inhalation in the patientts with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods　Ninety-eight patients with AECOPD were randomly divided into two groups. The basic therapy for the two groups were antibiotics, aminophyline and Solu-Medrol. The treatment group with 49 cases was given 2.5 ml combivent and 15 mg mucovent inhalation two times daily, while the control group with 49 cases was treated with 15 mg mucovent only.Results　There were not difference in symptom and sign between the two groups before therapy. But on the seventh day between the two groups after therapy, there were significant difference in disappearance rate of symptom and sign (P<0.05), also, there was significant difference in PaO₂, PaCO₂ and lung function (FEV₁, FEV₁/FVC%)(P<0.05).Conclusion　As an effective treatment, combivent and mucovent inhalation can relieve the symptom，lung function，low-oxygen and high-carbon dioxide of patients with acute exacerbations of chronic obstructive pulmonary disease.]]> 2018/12/3 8:39:12 YlN Shi-qi, SANG Yu-lan 628true ［Abstract］　Objective　To explore the aggressive growth characteristics in peripheral parts and central parts of keloid by analysing the insulin-like growth factor-I (IGF-I) and the insulin-like growth factor-I receptor (IGF-IR) index.Methods　Fibroblasts of 8 keloids cases and 4 normal skin cases were investigated by immunohistochemical analysis of IGF-I and IGF-IR. IGF-I and IGF-IR index of difference parts in keloids and normal skin were compared.Results　These were no positive fibroblasts in normal skin samples. The IGF-I and IGF-IR index of peripheral parts of keloids are higher than those of central parts, and there is significant difference(P<0.05).Conclusion　The difference in distribution of IGF-I and IGF-IR index may be responsible for the aggressive growth of keloid.]]> 2018/12/3 8:39:43 HUNG Xin, SHAN Sheng-guo, WEI Hai-ming, et al. 627true ［Abstract］　Objective　To 1earn bone marrow morphocytology in systemic lupus erythematosus(SLE) patients with peripheral cytopenia.Methods　The smears of bone marrow aspirates obtained from 34 SLE patients who had bone marrow aspiration due to peripheral cytopenia (WBC<4×10⁹/L, or Hb<100 g/L, or platelet count<100×10⁹/L) were examined retrospectively.And the smears of the bone marrow aspirates obtained from 14 healthy controls, 18 patients with MDS (refractory anemia), and 26 patients with idiopathic thrombocytopenic purpura (ITP) were inserted randomly among those obtained from the SLE patients.Results　Of the 34 SLE patients, 24(70.6%) had dysplasias, including: erythroid cell multinuclearity (trinuclear or more) 10(29.4%), megaloblastoid changes 8(23.5%), pseudo Pelger-Hüet abnormalities 12(35.3%), separated nuclear megakaryocytes 8(23.5%), and micromegakaryocytes 10(29.4%).Conclusion　This study found that bone marrow dysplasia can be observed in all lineage cells of SLE patients, We conclude that the bone marrow may be a target organ in SLE with cytopenia.]]> 2018/12/3 8:39:43 JIANG Lie-jun, BI Yi-fang 626true ［Abstract］　Objective　To investigate the change of the biochemistry and immunity indexes in the children with hemophagocytic syndrome and its clinical significance. Methods　The immunofluorescence and enzyme immuno assay methods were applied for detecting the biochemistry and immunity indexes of vein blood specimens from the children with hemophagocytic syndrome （the experiment group） and the ones with ordinary respiratory tract infection （the comparison group） respectively.Results　Compared with the comparison group GPT、GOT、LDH、TBIL、TG、FP and β₂-PG of the experiment group increased, in the same time, FIB and ALB reduced(P<0.05).Conclusion　Some biochemistry and immunity indexes have obvious changes in children with hemophagocytic syndrome, it is significant to diagnose and take pertinent therapy for this disease.]]> 2018/12/3 8:39:43 ZHENG Yu-feng, QIN Li-jun, SHEN Na-jun, et al. 625true ［Abstract］　Objective　To study the effect and the safety of low molecular weight heparin calcium on the treatment of progressive cerebral infarction.Methods　Seventy-six patients with progressive cerebral infarction were randomly divided into low molecular weight heparin calcium treated group (treatment group) and control group. The control group was given routine drug treatment and the treatment group was given low molecular weight heparin calcium treatment at the same time.Results　The effective rat was significantly highter in the treatment group than in the control group and hemodynamic change of treatment group were apparently better than those of control group.Conclusion　The treatment of progressive cerebral infarction with low molecular weight heparin calcium is safe and efficient.]]> 2018/12/3 8:39:43 YANG Sheng-xian 624true ［Abstract］　Objective　To approach the feature of abnormal electroencephalogram(EEG) of newborn with hypoxic-ischemic encephalopathy(HIE).Methods　One hundred and four newborns with HIE who visited in Guangxi Women and Children Health Hospital from January 2006 to October 2008 and diagnosed as abnormal EEG in first time were retrospectively analyzed.Results　(1)Of the 104 newborns with abnormal EEG, there were low tension and slowly frequency in 44 patients, electrical silence in 28 patients, eleptiform discharge in 22 patients, burst suppression in 8 patients and dissymmetry in 2 patients. (2)There were 16 patients with mild HIE, of them there were low tension and slowly frequency in 12 patients, eleptiform discharge in 4 patients; There were 46 patients with moderate HIE, of them there were low tension and slowly frequency in 28 patients, eleptiform discharge in 10 patients, electrical silence in 4 patients, and burst suppression in 2 patients and dissymmetry in 2 patients; There were 42 patients with severe HIE, of them there were low tension and slowly frequency in 4 patients, eleptiform discharge in 8 patients, electrical silence in 24 patients and burst suppression in 6 patients.Conclusion　The main pattern of abnormal EEG of newborn with HIE are low tension and slowly frequency, electrical silence and burst suppression; the degree of EEG is in accordance with clinical grading of the newborn with HIE.]]> 2018/12/3 8:39:43 FENG Jun-tan, SONG Xiong, LIU Xian-zhi, et al. 623true ［Abstract］　Objective　To compare safety and benefits of laparoscopic versus open appendectomy.Methods　The 124 cases underwent laparoscopic appendectomy were compared with another 108 cases underwent open appendectomy from February 2004 to October 2008. The patients were selected randomly. Results　The recovery time of gastronintestinal function and the time of hospital stay in laparoscopic appendectomy group were shorter than that in open appendectomy group (P<0.01). The operative and anesthesia time of laparoscopic appendectomy were longer than that of open appendectomy. The laparoscopic appendectomy had fewer infection of incision.Conclusion　The laparoscopic appendectomy is proved to be safe and efficient with shorter hospital stay, lighter pain, few infection of incision. It will be first choice of appendectomy gradually.]]> 2018/12/6 8:49:55 ZHONG Li, LU Chong-liang, TIAN Xiao-lin, et al. 622true ［Abstract］　Objective　To investigate the effect of sevoflurane preconditioning on plasma TNF-α levels in children undergoing cardiac surgery with cardiopulmonary bypass(CPB).Methods　Twenty-four ASA Ⅰ or Ⅱ patients (11 male, 13 female) aged 0.9～12years, weight 6～26 kg, were randomly allocated to one of two groups (n=12 each):experimental group (group S) and control group (group C).In group S, the patients were inhaled 2% sevoflurane from anesthesia induction until aortic cross clamping while in group C the patients were inhaled only 100% O₂.Blood samples were obtained from radial artery before induction of anesthesia(T₀), 20 min after aortic unclamping(T₁), 4 h(T₂) and 24 h(T₃) after CPB for determination of plasma levels of TNF-α and cTnI.Results　Plasma levels of TNF-α and cTnI were significantly increased at T_1～3 as compared with the baseline values at T₀ in both groups and were significantly lower in group S than in group C (P <0.05）. Conclusion　Sevoflurane preconditioning can effectively inhibit the inflammatory response in children undergoing open heart operation with CPB.]]> 2018/12/6 8:49:55 HE Bing-hua, JIANG Ying 621true ［Abstract］　Objective　To analyze the change of platelet parameters and coagulation indices in patients with hepatic cirrhosis, and the relation between the change and Child-Pugh score in hepatic cirrhosis.Methods　In 430 patients with hepatic cirrhosis and 65 healthy people, the platelet and its parameters(PLT、MPV、PDW 、PCT） were detected by KX-21N type auto counter, the coagulation indices（PT、APTT、TT、FIB）were detected by CA-6000 type auto blood coagulation analyzer, the results were compared. Results　Compared with healthy group, PLT、PCT descended evidently and MPV、PDW increased significantly, PT、APTT 、TT were longer and FIB descended evidently in patients with hepatic cirrhosis, there were significant difference between two groups（P<0.01）. The PLT, MPV, PDW, PCT, PT, APTT, TT and FIB in the hepatic cirrhosis group had statistical significance followed by Child-Pugh score A to C （P<0.01）.Conclusion　There is abnormality of platelet parameters and disturbance of blood coagulation in patients with hepatic cirrhosis, the platelet parameters and coagulation indices help to determine the damage degree of hepatic cirrhosis and prognosis in hepatic cirrhosis.]]> 2018/12/6 8:49:55 SHI Ren-fang, TANG Mei-yuan 620true ［Abstract］　Objective　To investigate the influence of different drug delivery time on the morning blood pressure surge(MBPS) in elderly patients with hypertension in accordance with the time of drug delivery of chronotherapeutics. Methods　With 180-EA ambulatory blood pressure monitoring system, the ambulatory blood pressure monitoring method was used to screen out 206 patients with MBPS from elderly patients with hypertension. The 206 patients with MBPS were randomly divided into group A and B. Routine treatment of drug administration at 8∶00 AM was taken by group A, while evening bedtime administration was used in group B which lasted four weeks. Before and after treatment, ambulatory blood pressure monitoring inspection were carried out. Results　Before treatment, there was no significant difference in 24 h average blood pressure, daytime average blood pressure, mean blood pressure at night and morning blood pressure surge between two groups (P>0.05). After treatment the 24 h average blood pressure, daytime average blood pressure, mean blood pressure at night and morning blood pressure surge of the two groups were significantly decreased. Compared with the data before treatment, there was a significant difference (P<0.01). After treatment Group B′s blood pressure at night and morning blood pressure surge decreased significantly, and compared with the data after treatment of group A, there was a significant difference (P<0.01). Blood pressure of group B resumed circadian rhythm. Conclusion　It is better to take chronotherapeutics to correct the high load of blood pressure at night, to restrain the morning blood pressure surge, and to restore the circadian rhythm of blood pressure of obvious morning blood pressure surge in elderly patients with hypertension.]]> 2018/12/6 8:49:55 LIANG Ling, LIU Wei-hua 619true ［Abstract］　Objective　To explore how to choose right approach of repair of inguinal hernia.Methods　Two hundred and fifty-one cases undergone inguinal herniorrhaphy from Oct.2005 to Nov.2008 were collected, and the effectivness, complications and cost of varied approachs of inguinal hernia repair were analyzed comparatively and retrospectively.Results　Operating time was different between laparoscopic approach and open approach(P<0.05); the patients with laparoscopic approach was earlier to be discharged and retun to work than that with open approach (P<0.05); cost of laparoscopic approach was higher than that of open approach (P<0.05); the rate of complication and recurrence between two approachs was similar, dispite there were 4 serious complications in IPOM. Conclusion　Open tension-free inguinal herniorrhaphy is the most frequent approach of inguinal hernia repair, especially huge hernia.Iaparoscopic inguinal herniorrahphy has the advantages of slighter pain, smaller incision, short hospital stay and earlier return to work, TEP is suitable to direct inguinal hernia, TAPP to recurrent inguinal hernia, and IPOM +internal ring closing may occur severe complications.]]> 2018/12/6 0:00:00 YU Jun-ying, FENG Ze-rong, HUANG Shun-rong, et al. 618true ［Abstract］　Objective　To evaluate the efficacy and safety of acupuncture and Oxybutynin hydrochloride sustained release tablets in treatment of patients with motor urge urinary incontinence(MUUI).Methods　Forty-patients with MUUI after transurethral resection of the prostate were divided into two grouds randomly, 20 patients in each group. There were no significant difference in age and course of disease(P>0.05).The testing group were treated by acupuncture and oxybutynin hydrochloride sustained release tablets.The data of each patients we collected and analysed before and after the treatment which included micturition frequency in 3 days, the average daily frequency of micturition, the average volume and the total incontinence frequency in 3 days. Results　Each grouds′data had significantly different before and after treatment(P<0.05).There wasn′t significantly different between the testing group and the control group in the case of efficacy.But there was significantly differen between the two group in adverse reactions（P<0.05）.Conclusion　There are the same efficacy in the two treatment methods, but acupuncture has a lower adverse reactions rate.]]> 2018/12/6 8:49:55 ZHENG Fang, LI Feng, WU Song-he 617true ［Abstract］　Objective　To investigate the methods of the treatmennt and prevention of the complications of laparoscopic cholecystectomy. Methods　From August 2003 to December 2008, the data of 561 case of laparoscopic cholecystectomy were analysed.Results　Laparoscopic cholecystectomy was successfully performed in 558 of 561 cases(99.47%).There were 4 cases（0.71%) with complicatios.These involved 2 cases（0.36%） with a biliary leak, 2（0.36%）complete transversal injury of the common bile duct. The operative duration was (51.36±20.46)min; The duration for hospitalization after operation was (4.15±1.36)d. Conclusion　Laparoscopic cholecystectomy is minimally invasive technique which can be carried out safely and effectively.The complicatios can be minmized by emphasizing prevention and improving the techniques of laparoscopic cholecystectomy.]]> 2018/12/6 8:49:55 JIANG Wen-shu, LU Bang-yu, LIU Zu-jun 616true ［Abstract］　Objective　To observe the efficiency of noninvasive positive pressure ventilation（NPPV）in the treatment of patients with severe acute left heart failure. Methods　The clinical data of 61 patients with acute left heart failure from January, 2006 to May, 2008 were retrospectively analyzed. In addition to conventional treatment，33 patients accepted NPPV by a face mask connected to a ventilation set in pressure support ventilation（PSV）and positive end-expiratory pressure(PEEP). The change of clinical symptoms， respiratory rate（RR）, heat rate（HR）, mean arterial pressure（MAP）, arterial blood gas (pH, PaO₂, PaCO₂, SpO₂) of two groups at admission and at 2 hours, 1 day after NPPV were compared. Results　After NPPV, the clinical symptoms had been improved significantly. All the clinical parameters showed a statistical differences（P all<0.05）compared with those before NPPV and the routine treatment(RT) group. The mortality was remarkably lower in the NPPV group（9.09%）than that in the RT group（28.57%）（P<0.05）. The mean length of hospital stay was significantly shorter in the NPPV group than that in the RT group（P<0.05）.Conclusion　NPPV can improve symptoms and hypoxemia in patients with the severe acute left heart failure rapidly. It is a safe and effective method in treating the severe acute left heart failure.]]> 2018/12/6 0:00:00 ZAI De-fu, LI Ming 615true ［Abstract］　GDNF, a member of the transforming growth factorβ, is known to demonstrate neuroprotective effects on dopaminergic neurons through a heterodimetric receptor complex consisting of a transmembrane receptor tyrosine kinase, Ret, and the ligand binding component GDNF-family receptor α1 (GFRα1). It is demonstrated that GDNF enhances the survival and morphological differentiation of dopaminergic neurons. Many studies have examined GDNF therapy as a treatment for various diseases both of the central nervous system (CNS), including stroke, spinal cord injury, traumatic brain injury and neurodegenerative diseases, such as PD, and amyotrophic lateral sclerosis (ALS) and peripheral nervous systems, such as sympathetic neuron，parasympathetic neuron，peripheral motor neuron and sensory eurons. GDNF is considered to be one of the strongest neuroprotectants for dopaminergic neurons. In this review article, We have a brief rewiew about the neural protection of the GDNF in resent years. The future of GDNF therapy is uncertain, although GDNF has strong neuroprotective and neurorestorative effects. Steady and continuous efforts are required to elucidate the potencies of GDNF and its potential contribution to PD patients.]]> 2018/12/6 8:50:23 FAN Rui-fang, SHEN Yue-fei 614true ［Abstract］　Leukotriene is a very important mediators of inflammation. This article reviews current status and research development of leukotriene, including the signal transduction, the related pathophysiology, and the clinical application of the related receptor antagonist.]]> 2018/12/6 8:50:23 HE Shuang, DAI yan, DU hua 613true ［Abstract］　The digonositic or trement level of coronary heart disease(CHD) has made great development, but the pathogeny is still unknowen.Revently a large evidence of study in pathology manifest there is a link between chornic infection and coronary heart disease. Pathogenic microorganisms, including pathogen(Chlamydia pneumoniae, CPn;Mycoplasma pneumoniae, MPn), virus(Cytomegalvirus, CMV;Herpes simplex virus, HSV;Enstein-Berrvirus, EBV;HAV, HIV, HBV, Influenzavirus), bacterium (Helicobacter pylori, HP;Streptococcus, H. Influenza) etc is infection factors.The infection factors affect stableness of atherosclerotic plaque.Cytokine(TNF、IL-6、CRP) and adhesion molecule induce vascular cell injury. Application of the antibotic in the treatment of CHD has achieved some progress.In this article, the progress in this field are summarized.]]> 2018/12/6 8:50:23 DUAN-hao, LIN Feng-xian, ZHANG Hong-kao, et al. 612true ［Abstract］　Calcitonin gene-related peptide (CGRP) is known to be the most powerful vasodilator peptide in the body at present, and participate in a number of important features of the regulation. Diabetic microangiopathy is a common chronic complications, mainly involving kidneys and eyes. CGRP′s strong role that include expansion of blood vessels, inhibition of vascular smooth muscle cell proliferation, protection of endothelial cells, and inhibition of vasocontrictive effect of endothelin involve in the development of diabetic kidney disease and the occurrence of new blood vessels of diabetic retinopathy, meanwhile, and play an important role in both the occurrence and development. Studying the change trend of CGRP in microvascular disease can provide a basis for the early diagnosis and treatment for diabetic microangiopathy.]]> 2018/12/6 8:50:23 NING Gai-jun, LONG Yan, SU Ke 611true ［Abstract］　C-peptide and NO are the main participants in pathology of diabetic renal disease，with a wide range of biological activity. This paper reviews their molecular structure, effect mechanism and the evolution of pathology in diabetic nephropathy, and reveal the new ideas to prevent and control diabetic nephropathy at cytokines level on the multi-factor mechanism.]]> 2018/12/6 8:50:23 YUAN-Qing, LIN Fa-quan 610true ［Abstract］　Congenital absence of vagina is congenital malformation due to incapacity of development of paramesonephric duct or stop of development of the terminal of paramesonephric duct and failure of extension.There are many Surgery methods of vaginoplasty, the mode of laparoscopic peritoneum vaginoplasty is safe and effective and less traumatic, and it can reform the patients′ life quality.]]> 2018/12/6 8:50:23 LI Jing-ling, MA Gang 609true ［Abstract］　 Laparoscopic radical surgery for colorectal cancer has been increasingly popularized recently. The article reviews and summarizes the current status of laparoscopic radical surgery for colorectal cancer on the operation modes, technical advantages, outcomes and cost-benefit analysis, changes of immune function, and tumor-free technique.]]> 2018/12/6 8:50:23 HUANG Shi-feng, HUANG Shun-rong 608true ［Abstract］　Hirschsprung′s disease (HD), a congenital disease, is characterized by the absence of ganglion cells in the ganglion plexuses of the caudal most gut. It stands as a model for complex multifactorial or multigenic disorders. In the last two decades, there has been a greater understanding of the etiopathogenisis and pathogenesy of hirschsprung′s disease. The goals of this review are to summarize progress in the study of etiological factor, such as genic mutation, the disorders of the interstitial cells of Cajal and connexin 43 (Cx43), the effect of environment.]]> 2018/12/6 8:50:23 JIANG Li, WANG Hong 607true ［Abstract］　With the improvement of apparatus and the application of 2-D ultrasoic imaging scanner with high resolution combined with color Doppler ultrasonic imaging, the early diagnosis for small hepatic carcinoma is possible. Rapidly developing contrast-enhanced ultrasonic technique and 3-Dimaging scanner have been widely applied to the diagnosis for small hepatic carcinoma. The early and exact diagnosis for malignant tumor of liver will be reliable through ultrasonically-guided biopsy of liver.]]> 2018/12/6 8:50:23 XU Chun-mei 606true ［Abstract］　Objective　To explore the differential diagnosis value of CEA, NSE, CY_21-1 and GLU in tuberculous effusion(TE) and malignant pleural effusion(MPE).Methods　 The levels of the four markers in 42 cases of MPE and 54 cases of TE were detected by electrochemilumin-escence immunoassay.Results　The levels of four markers in MPE group were significantly higher than that in TE group（P < 0. 05）.The sensitivity for each marker of CEA, NSE, CY_21-1 in the diagnosis of MPE was 64.3%, 26.2%, 57%, respectively， specificity was 94.4%, 94.4%, 80.4%, respectively. Combined three markers in the detections of in MPE, the sensitivity and specificity were 90.5% and 83.3%, respectively. Conclusion　 Combined detection of four markers of CEA, NSE, CY_21-1　and GLU has significant value in the differential diagnosis of TE and MPE.]]> 2018/12/12 16:20:04 ZHANG Jin-hui, HUANG Li-xiao, WANG Qi 605true ［Abstract］　Objective　 To investigate the regularity and clinical significance of electrotonic modulation of the T wave （EMTV）within 3 days after radiofrequency current catheter ablation（RFCA）in idiopathicventricular tachycardia.Methods　 The sequence of ventricle depolarization and the emerge of EMTV within 3 days after RFCA were observed in 87 patients with idiopathicventricular tachycardia (47 left idiopathic ventricular tachycardia, 40 right idiopathic ventricular tachycardia). Results　(1)There was no EMTV in the right outflow tract after RFCA;(2)The incidence rate of EMTV in left ventricular tachycardia was more higher than that in right ventricular tachycardia after RFCA(P<0.01); (3)The EMTV and the immediate effective time in RFCA was negatively correlated;(4)The characters of distribution of the lead and the depth 、width of EMTV after RFCA was different.Conclusion　EMTV can occur after RFCA in paroxysmal tachycardia patients, which is a normal electrophysiological manifestation of heart muscle after an abnormal depolarization.]]> 2018/12/12 0:00:00 LI Jing, ZHU Li-guang 604true ［Abstract］　Objective　To explore and establish a method for screening acquired metallo-β-lactamases (MBLs) in clinical microbiology laboratory.Methods　Seventy Acinetobacter baumannii strains with an imipenem′s MIC of ≥8 μg/ml and a ceftazidime′s MIC of ≥64 μg/ml were selected for MBLs screening. Imipenem-or ceftazidime-EDTA double disks test were used to detect the metallo-β-lactamases production. BlaIMP and blaVIM were amplified by PCR.And the results were evaluated with those of PCR analyses.Results　 Of the 70 clinical strains, there were 10 strains tested positive for MBLs genes by PCR: 6 for blaIMP and 4 for blaVIM. The imipenem-EDTA disks＇s sensitivity was 50% and the specificity was 28.6%.The ceftazidime-EDTA disks＇s sensitivity was 85.8% and the specificity was 13.3%. Conclusion　The inhibitor potentiated disk diffusion test using IMP-EDTA is a convenient and credible method for detecting acquired MBLs producer in clinical microbiology laboratory.]]> 2018/12/12 0:00:00 SHI Ying-hong, FENG Ping 603true ［Abstract］　Objective　To explore the effect of pulmonary surfactant（PS）on neonatal respiratory distress syndrome（NRDS）.Methods　 Nineting patients with NRDS were treated with mechanical ventilation and PS(treatment group), another 20 patients were treated with mechanical ventilation(control group). Gestational age and newborn weight were similar(P>0.05)between two groups. All patients were evaluated in blood-gas analysis, the parameter of mechanical ventilation, mechanical ventilation time, complications, time in hospital and fatality rate. Results　 After PS treatment, the level of PaO₂ increased remarkably(P<0.01), and the level of PaCO₂ decreased greatly (P<0.01).The PiP, MAP and FiO₂ dropped obviously(P<0.01).The mechanical ventilation time, complications and time in hospital were different significantly between two groups (P<0.05).The fatality rate was not different between two groups (P >0.05).Conclusion　 PS therapy has more curative effect on NRDS, it can improve oxygenation of NRDS and reduce the mechanical ventilation time, complications and time in hospital, but it can not reduce the fatality rate.]]> 2018/12/12 16:20:04 YANG Tong, LIN Xing-pin, HUANG Xian-wen, et al. 602true ［Abstract］　Objective　 To protect the periodontal health of patients wearing the reformed transparent full-arch wraparound retainers and evaluate the effects of the oral hygiene care during maintenance. The periodontal conditions were analyzed between the reformed transparent full-arch wraparound retainer and the Hawley′s retainer.Methods　 Eighty patients required retention after orthodontic treatment were divided into two groups. Patient wore the reformed transparent full-arch wraparound retainers or Hawley′s retainer was random. Each group had 40 patients. All patients were undergone scaling after remove of the fixed appliances and PD, PLI and GI were examined as the basic line data. Afollow-up examinations of PD, PLI and GI of each patient were carried out in one month, three months, six months and twelve months respectively during retention periods. In the mean time, in order to know the periodontal conditions in different periods and treat odontal and periodontal diseases in time, besides general oral health instruction, the methods of oral hygiene examination and maintenance by myself were instructed. Results　 (1)The data of PLI of basic line were significantly different from other different periods, but PD and GI were not different from other periods in the two groups. (2) PD in three months and GI in twelve months showed significant difference between two groups（P<0.05）.Conclusion　(1) There is no bad effects on patient periodontal tissues when they wear transparent full-arch wraparound retainer if only the retainer are well designed and oral hygiene dealt efficiently. (2)No matter what type of retainer patient wear, some methods must be taken to prevent odontal and periodontal diseases.]]> 2018/12/12 16:20:04 ZHOU Yan, FANG Zhi-xin, WEI Hei-ping 601true ［Abstract］　Objective　To observe and investigate the effects of intermittent hemofiltration in the treatment of multiple organ dysfunction syndrome(MODS). Methods　 Thirty four patients with MODS were selected. Changes of BUN and serum CRE, K⁺, pH and acute physiology and chronic Ⅱ scores before and after treatment were compared. Mean arterial pressure, central venous pressure and heart rate were monitored during the treatment and their changes before and after treatment were compared.Results　 Compared with that before treatment, all above of datas were significant changes. There were statistically significant difference before and after treatment (P<0.05).Conclusion　Intermittent hemofiltration can effectively clear extra solutes, appropriately adjust ionic and acid-base balance with little disturbance on blood flow dynamics. It is a effective multiple organ function support therapeutic method.]]> 2018/12/12 0:00:00 GONG Rong, GUO Hua, LIANG Zhu, et al. 600true ［Abstract］　Objective　 To summarize the therapeutic effect of lobectomy of liver for primary intrahepatic bile duct stone.Methods　The clinical therapeutic effect of 52 cases suffering from intrahepatic bile duct stone who underwent lobectomy of liver with other operation modality in nearly 6 years were retrospectively analyzed. Results　Among all the cases, 2 cases were treated with right lateral hepatectomy, 2 cases with right posterior lobe liver resection, 9 cases with irregular liver resection， 13 cases with left half liver resection, 26 cases with left lateral lobe resection.Remnant stones were found in 7 cases after operation, the stones of 5 cases were removed by choledochoscopy.Conclusion　 Lobectomy of liver is now a ideal method for the treatment of primary intrahepatic bile duct stone.]]> 2018/12/12 16:20:04 LUO Kun-lun, YU Feng, FANG Zheng, et al. 599true ［Abstract］　Objective　To evaluate the clinical effects on the treatment of thoracolumbar bursting fracture and dislocation by AF pedical screw spinal system. Methods　The clinical treatment result of 72 cases of thoracolumbar bursting fracture and dislocation with the nerved injury treated by AF pedical screw spinal system were reviewed and analyzed.Results　All 72 cases were followed up an average period of 4 years and 8 months.There were no special complication. The average height of anterior border of vertebral body raised from preoperative average height of 60% to postoperative average height of 95%.The cobb′s angle improved from preoperative average of 20° to postoperative average of 3°.The neuro function recovered more thanⅠgrade.Conclusion　 AF pedical screw spinal system treating the thoracolumbar bursting fracture and dislocation is a kind of effective and ideal clinical method.It have characteristics of good reduction, good decompression, orthopaedic in three-dimensional space and short segmental transpedicular fixation.]]> 2018/12/12 0:00:00 LI Hong-yu, YIN Dong, LIANG Bin, et al. 598true ［Abstract］　Objective　To study the therapeutic effects of manipulation and fixed-point rotation reposition in patients with knee osteoarthritis.Methods　 One hundred and twenty patients with knee osteoarthritis were randomly divided into two groups. The treating group was treated with manipulation and fixed-point rotation reposition while the control group was treated with mere manipulation. The therapeutic effects of the two groups were judged by the improvements of clinical symptoms and their scores, and their relapse rates were compared after one year′s follow-up.Results　 The total effective rates in the treating group and control group were 93.3% and 85% respectively, P<0.05. The relapse rate was 7.1% in the treating group and 21.6% in the control group, P<0.05.Conclusion　 The therapentic effect of manipulation and fixed-point rotation reposition in patients with knee osteoarthritis was better than that in patients with the treatment of mere manipulation.]]> 2018/12/12 16:20:04 YANG Jia-zhen, CHEN Chun-yu, QIN Yi-jue, et al. 597true ［Abstract］　Objective　To evaluate the prevalence of congenital heart disease and to determine the age distribution of congenital heart disease by coloure flow doppler echocardiography and to recognize the importance of clinically adult congenital heart disease.Methods　Two hundred patients with suspected congenital heart disease underwent colour flow doppler echocardiogram with muti-sectional approach in echocardiography laboratory. Pulmonary hypertension were assessed by tricuspide regurgitation gradient.Results　Two hundred patients had congenital heart disease,aged from 6～68 years. Male 89, female 110.54（27%） patients were less than 18 years,111(58%) patients were aged from 18～44 years, 31(16%) patients were older than 45 years.47 patients underwent transesphogeal echocardiography.62 atrial septal defect, 55 ventricular septal defect,19 persistent ductus arteriosu (PDA).15 ventricular septal aneurysm, 49 other congenital heart disease. only 38 patients underwent operation or interventional treatment.Conclusion　Modern colour flow doppler echocardiography is an important approach for the diagnosis of adult congenital heart disease. Appropriate treatment is important for the life quality and prolonge life.]]> 2018/12/12 16:20:04 ZHOU Qing-hua,WU Yu-li 596true ［Abstract］　Objective　To analyze the effect of Coulter flow cytometry with self-mix reagents on immunophenotyping of acute leukemia.Methods　The physical and chemical properties, accuracy, precision and the application effect on testing immunophenotyping of acute leukemia antigens between the original and the self-mix reagents of the hemolysis reagent, sheath fluid and cleaning fluid, were compared respectively.Results　The physical and chemical properties were basically the same in two reagents; The within-run CV were less than 2% by testing several cell membrane antigens of acute leukemia with two reagents, every for 20 times; there were no statistics significance in detective results of membrance and cytoplasmic antigens between two reagents (P>0.05), and the correlation coefficient of intracellular antigen cMPO and cCD79a were bigger than 0.970.Conclusion　The application effect of self-mix reagents is good, and the original reagents could be replaced by them when flow cytometry is applied to immunophenotyping of acute leukemia.]]> 2018/12/12 16:20:31 LI Ruo-lin, QIN Xue, MO Wu-ning，et al. 595true ［Abstract］　Objective　To observe and compare long curative effect and complications of the endoscopic internal and external drainage in the treatment of different lesions and different parts of obstruction of bile duct.Methods　The date of 506 cases of obstruction of bile duct drained by the duodenoscope from Octomber 2003 to December 2007 were reviewed.Results　Four hundred and eighty-one cases were successful in 506 and the successful rate was 95.1%. The symptoms of obstruction had remittence(jaundice abatment, pain relief and temperature descent).Conclusion　The endoscopic drainage for treating obstruction of bile duct has following merits: less trauma, less pain, quick recovery, short hospitalization time and good effect.Paying attention to selection of drain site can further improve the successful rate of endoscopic biliary drainage.]]> 2018/12/12 16:20:31 LI Rui-xian, PAN Xiao-ping 594true ［Abstract］　Objective　To study the pathogenetic mechanisms and treatment of malignant tumor complicated by limb deep venous thrombosis (LDVT). Methods　The data of 21 patients with LDVT after operations for malignant tumor from January 2000 to June 2006 were collected and analyzed retrospectively. Results　The patients with LDVT were 5.4%(21/392)of overall deep venous thrombosis of the same period.The left leg was involved in 13 of the patients, and right leg in 8 cases. After the treatment, patients′ condition were improved in some extent. Conclusion　The causes of LDVT are various.The early diagnosis and therapy in time is the key to improve prognosis.The importance of prevention of LDVT after operation for rectal cancer should always be emphasized.]]> 2018/12/12 0:00:00 WANG Qing, MA Chun-lin 593true ［Abstract］　Objective　To observe the effects on stress response of the patients undergoing laparoscopic surgery through comparing target-controlled infusion(TCI) with propofol and remifentanil with combined intravenous inhalation anesthesia.Methods　Forty ASA Ⅰ～Ⅱ patients undergoing elective laparoscopic gastrectomy or intestinectomy surgery were randomly divided into two groups: group T underwent intravenous TCI of propofol and remifentanil(n=20) and group I underwent combined intravenous inhalation anesthesia (n=20).The muscular relaxation was maintained by intermittent boluses of vecuronium. HR、SBP、DBP and the plasma glucose concentration, epinephrine, norepinephrine and cortisol were mesured before induction(T₀), immediately after tracheal intubation(T₁), at 5min before pneumoperitoneum (T₂), at 10min after pneumoperitoneum (T₃), at 60min after pneumoperitoneum (T₄) and at 10min after cease pneumoperitoneum (T₅).Results　HR、SBP、DBP in group T were no significant difference at every point（P>0.05）, and significant differences were found at T₁, T₂, T₃, T₄, T₅compared with point T₀(P<0.05) in group I. The plasma glucose concentration, epinephrine, norepinephrine and cortisol increased signifisently at T₃, T₄, T₅ in group T, but were significantly less than that in group I(P < 0.05).Conclusion　 Target-controlled infusion(TCI) restrains stress response effectively and maintains the hemodynamic stabilization response.]]> 2018/12/12 0:00:00 HU Yan-yan, HUANG Zhong-hua, LIANG Ning, et al. 592true ［Abstract］　Objective　To evaluate the accuracy and the consistency of the result which was got by different types of hematology analyzer in the routine work.Methods　The Gen-s System2 hematology analyzer was used to determine 40 blood specimens, which included high, middle and low classes. Every specimen was parallelly determined two times by the same instrument. The mean value was used to analyze several parameters and the results, which were determined by other types of hematology analyzer, were evaluated in items including WBC, RBC, HGB, PLT, HCT got by Gen-s System2 hematology analyzer.Results　(1)The accuracy of four Hematology analyzers was good.(2)The results of t-test in WBC, RBC, HGB, PLT and HCT showed that there are no statistical differences (P>0.05). (3)Compared to instrument parameter, the correlation coefficient of each instrument were good(r>0.975).(4)Compared with the regression curve and the regression equation, the error　of each instrument system was known. Conclusion　(1) The system error between instrument is promptly found through the test of evaluating the fresh and whole blood by hematology analyzer. (2)The accuracy and the consistency of the result, got by hematology analyzer in the identical laboratory, can be enhanced and guaranteed with the verification testing of hematology analyzer in determining the fresh and whole blood specimen in the identical laboratory.]]> 2018/12/12 16:20:31 LIU Xin-feng, MO Wu-ning, LAN Hui-hua. 591true ［Abstract］　Objective　To explore the effects of early combined therapy for nasosinusitis complicated with nasal adhesion in patients with nasopharyngeal carcinoma after radiotherapy.Methods　Thirty-eight patients with nasopharyngeal carcinoma, who suffered from sinusitis complicated with nasal adhesion after radiotherapy and were treated by conservative therapy with unsatisfactory curative effect, were treated by endoscopic sinus micro-wound surgical intervention in 2～4 months after radiotherapy, and the curative effects and the factors influencing the curative effects were observed.Results　Twenty-three cases (60.5%) were completely cured, 15 cases (39.5%) were improved and no case (0%) showed ineffective. The total effective rate was 100%.Conclusion　For some of the nasosinusitis complicated with nasal adhesion in patients with nasopharyngeal carcinoma after radiotherapy, it will attain satisfactory curative effect take micro-wound surgical intervention early, strictly control the wound area in the surgery and adopt appropriate postoperative combined therapy.]]> 2018/12/12 16:20:31 MENG Ti-hang, WANG Chun, LI Zhu-yang, et al. 590true ［Abstract］　Objective　To investigate the effects of Chinese medicines cryptotanshinone, tanshinone II-A, berberine, baicalin, matrine on the lipid synthesis of SZ95 sebocytes compared with isotretinoin.Methods　Lipid contents in the SZ95 sebocytes were labeled with a fluorescence dye(Nile red) and analyzed using flow cytometry.Results　Lipid synthesis was inhibited by 1.25×10^-7M tanshinone II-A（-34.2%）, 1×10^-4M baicalin(-30.1%), 1×10^-7M isotretinoin（-21.1%）， 1.25×10^-7M　Cryptotanshinone（-16.2%）and 1×10^-5 M Berberine（-7.8%）also decreased lipogenesis but no statistical significance was found. Matrine increased lipogenesis（26.913%）.Conclusion　Tanshinone II-A and baicalin may have a direct effect on lipid synthesis in sebocytes.]]> 2018/12/12 16:20:31 LU Quan-xing, ZHANG Jin-yu 589true ［Abstract］　Objective　To explore the variety of blood biochemical indicators after asphyxia in premature infants.Methods　The levels of K⁺、Na⁺、Cl^-、myocardial enzymes， BUN、CO₂CP、Cr、Ca²⁺ in the premature infants in the experimental group and the control group were determined by electrode method, rate method and enzymatic method respectively, and the indicators′ difference between two groups were compared.Results　 The levels of myocardial enzymes， BUN、Cr rose, but CO₂CP、Na⁺、Cl^-、and Ca²⁺ decreased after asphyxia (K⁺ in blood serum changed only in the group of severe asphyxia); enzymes，BUN、Cr rose and CO₂CP、Na⁺、Ca²⁺ declined in the group of intrauterine asphyxia, there was a statistically difference compared with group of birth asphyxia.Conclusion　The changes of biochemical indicators in blood might occur after asphyxia in premature infants, so which can be regarded as the early monitoring indicators.]]> 2018/12/12 16:20:31 SHEN Yang, WANG Ling 588true ［Abstract］　Objective　To observe the feature of clinic and coronary angiography in the young patients with acute coronary syndrome(ACS).Methods　 The clinical data of coronary angiography in 422 patients with ACS who were divided into two groups (young group and elderly group) were analyzed retrospectively.Results　18.25% of patients with ACS were males aged 45 years old or less. In young group, the risk factors were related with smoking, hyperlipidemia and obese. Those patients have typical symptoms, less hospitalization mortality, more simple coronary artery lesion. While in elderly group, males were more than female, and there were more factors related with ACS, such as hypertension, diabetes, smoking and hyperlipidemia. The complex and diffusing coronary artery lesion were seen more often. Conclusion　The young patients with ACS have significantly different feature of clinic and coronary artery lesion which are different from those of the aged. Different treatments should be used to deal with patients with ACS in the different age.]]> 2018/12/12 0:00:00 WANG Hao, YANG Bo, WU Xu-bin, et al. 587true ［Abstract］　Objective　 To investigate the feasibility and safety of bedside temporary cardiac pacing via left subclavian vein guided by pacemaker electrocardiogram.Methods　Punctured the left subclavian vein by seldinger′s method, then the sheath was sent into the left subclavian vein.The temporary cardiac pacing electrode was sent into chambers of heart through the sheath until appearing ventricular premature beats or short paroxysmal ventricular tachycardia.Connected the pacing electrode to the temporary cardiac pacemaker, the pacing rate, output voltage and sensitivity were set up 20bpm over the self heart rate, 3～5V and 2mV respectively.The 12-leads pacemaker electrocardiogram was recorded after complete pacing and the site of the pacing electrode was adjusted according to the QRS configuration of Ⅱ、Ⅲ、 aVF leads until the dominant wave of QRS inversed. And QRS configuration of V1-V6 leads presented complete left bundle branch block.Results　 The pacing electrodes were inserted successfully in all of the patients, and all of them obtained satisfactory pacing effect, the operating time was 5～10 mins, the depth of the inserted electrodes was 25～30 cm, there were no operating related complications appeared.Conclusion　 Temporary cardiac pacing via left subclavian vein guided by pacemaker electrocardiogram was a sort of safe，effective and feasible approach, the achievement ratio of which was high and was worth to applied widely in the clinical practice.]]> 2018/12/13 9:29:22 HU Chang-xing, XU Guang-ma, LU Zhi-hong, et al. 586true ［Abstract］　Objective　To investigate the value of tumor markers changes in evaluation of effects of chemotherapy in patients with lung cancer. Methods　 Thirty eight patients with lung cancer were given 2 periods of chemotherapy of TP(Taxol+DDP) or EP(VP-16+DDP). Before the first and the third chemotherapy, the tumor markers changes of CEA, CYFRA21-1 and NSE and the changes of Chest CT were recorded.Results　 After the secend chemotherapy the levels of tumor markers apperently reduced, there were statistically difference compared with the value of the first chemotherapy. The changes of CEA in lung adenocarcinoma patients were valuable and so did CYFRA21-1 in lung squamous cell carcinomas patients and NSE in small lung cancer patients.Conclusion　Monitoring on CEA, CYFRA21-1 and NSE could help evaluate the effects of post-chemotherapy in patients with lung cancer, which is simple and cost-effective.]]> 2018/12/13 9:29:22 JIANG Ke-jia, DIGN Ming-dong， QIN Shao-yun 585true ［Abstract］　Objective　To explore the relation between the plasma fibrinogen and the pathological degree of coronary artery in the aged patients with metabolic syndrome.Methods　Retrospective analysis of angiographic coronary artery disease of 157 patients with metabolic syndrome was carried out. Each patient′s body mass index(BMI), non-same date blood pressure, blood fat lipoprotein, fasting blood glucose (FBG), and two hours postprandial blood glucose(PBG2h) were measured. According to the standard of Chinese Medical Association Diabetes Society, metabolic syndrome was diagnosed. Essential pathological degree of coronary artery was associated with the narrow diameter of coronary. The coronary diameter stenosis ≥50% was regarded as the significant lesions. The pathological degree of coronary artery adopted Gensini integral.Results　Along with the age growth, the pathological changing degree of coronary artery aggravated. The levels of plasma fibrinogen in the aged patients were higher than that in the control group(P<0.01). The fibrinogen elevating caused increasing of relative risk (RR) of coronary disease.Conclusion　Coronary disease is one of main clinical consequences of metabolic syndrome. Besides positively controlling the basic dangerous factors, we should also pay attention to and give intervention treatment to the dangerous factor plasma fibrinogen.]]> 2018/12/13 9:29:22 LIANG Ling，ZHU Li-guang 584true ［Abstract］　Objective　To observe the clinical effect and the mechanism of hyperbaric oxygen(HBO) in the treatment of vascular dementia (VD).Methods　 Eighty-two patients with the VD were divided into two groups at random:the control group (the pure drug group, 42cases,)and the experiment group(the HBO group, 40 cases).All of patients were tested by the cognitive impairment and dementia′s rating and the evaluation index of the symptoms improvement were valued by the Mini-mental state examination (MMSE) and annual daily living(ADL) before and after the treatment.Results　The comparison of the data before and after treatment showed, MMSE score changes in HBO group had significant differences (P<0.05), there were no significant difference (P>0.05)in the control group, ADL score had significant difference in the HBO group (P<0.05), there was no significant difference in the ADL score changes of the control group (P>0.05).Conclusion　 HBO play the rehabilitation role in the vascular dementia.]]> 2018/12/13 9:29:22 SONG Cheng-fu, HU Cai-di, GU Pei-fang, et al. 583true ［Abstract］　Objective　To explore the changes of bone marrow morphology results in the past 10 years.Methods　 Data were statistically analyzed from the cases in 1997 and 2007 respectively，according to morphology classification of bone marrow samples.Results　 The cases of hemopathy changed from 654 to 1184 between 1997 and 2007, the cases of acute leukemia increased from 277 to 510 during 10 years.Conclusion　 The cases, types and subtypes of hemopathy change greatly in the past 10 years, this analysis would be useful for the diagnose and study epidemiology of hemopathy.]]> 2018/12/13 9:29:22 LAN Hui-hua, CHEN Zheng-li, MO Wu-ning, et al. 582true ［Abstract］　Objective　To investigate the change of α-actinin-4 expression and the effect of benzapril on α-actinin-4 expression.Methods　STZ-induced diabetic rats were established, benzapril was given to it, immunohistochemical and RT-PCR were employed to study the change of α-actinin-4 protein and mRNA.Results　At week 8, compared with normal group, the expression of α-actinin-4 protein in diabetic group increased dramatically（P<0.01）;At week 12, the expression still raised（P<0.01）.The expression of α-actinin-4 mRNA was similar to immunohistochemical staining. At week 8, the expression of α-actinin-4 protein in benzapril group decreased when compared with diabetic group（P<0.05）; At week 12, it can also decreased, but had no statistical significance.Conclusion　The expression of α-actinin-4 increased in diabetic nephropathy and benzapril can normalize it.]]> 2018/12/13 9:29:50 YIN Yu-hong, LI Ying 581true ［Abstract］　Objective　To study the cause of EH and the relation between the cause and the prognosis of EH in infant.Methods　 The clinical data included the causes of perinatal period, the treatment and the prognosis were analyzed in 64 cases of EH.Results　The causes of perinatal period was 36 cases. The causes of non perinatal period was 16 cases involved the infection in respiratory system, digestive system and nervous system, 2 cases intracranial hemorrhage because of Vitamin K deficiency. Unknown cause was 12 cases. Most of cases were well， only 2 cases had sequelae in nevous system.Conclusion　The causes of perinatal period was the main reason of EH. The cases involved by hypoxic in perinatal period had sequelae in nevous system.]]> 2018/12/13 9:29:50 ZHOU Yu, HUANG Xiao-wei, MO Xiao-qing 580true ［Abstract］　Objective　To review the efficacy and safety of simvastatin in combination with fenofibrate in treatment of combined hyperlipidemia.Methods　 Forty-six cases of coronary heart disease with combined hyperlipidemia were randomized into two groups, 23 in each one. Group A included 16 men and 7 women, with a mean (SD) age of (60.01±8.25) years; group B included 15 men and 8 women, with a mean age of (60.00±7.8) years. Patients in group A took orally simvastatin at dose of 20mg at bedtime and fenofibrate 0.1g twice a day; and patients in group B were treated only with simvastatin at dose of 20mg at bedtime. Both regimens lasted for 24 weeks. Blood lipid measurements were planned before and after the study took place.Results　 Serum levels of total cholesterol (TC), triglycerides (TG) and low density lipoprotein-cholesterol (LDL-C) were decreased respectively by 27.8%, 56% and 41.4% in group A; and by 15.4%, 11.6% and 24.7% in group B. On the contrary, high density lipoprotein cholesterol (HDL-C) was increased by 22% in group A and by 11.5% in group B (P<0.05). Three patients with unstable angina pectoris were found in group A, and six in group B (P<0.05).Conclusion　 Simvastatin in combination with fenofibrate may provide a safe and efficacious treatment modality that enables achievement of several therapeutic goals in patients with combined hyperlipidemia who have high cardiovascular risk.]]> 2018/12/13 9:29:50 YANG Ping 579true ［Abstract］　Objective　To study the dentures for children with hypohidrotic ectodermal dysphasia.Methods　The dentures were fabricated according to the characteristics of children.Results　 The case with hypohidrotic ectodermal dysplasia was treated successfully with denture.Conclusion　 Fabrication and application of the dentures for children with hypohidrotic ectodermal dysplasia should be in accordance with their physiological characteristics.]]> 2018/12/13 9:29:50 XIE Li-li, LI Yu-ling 578true ［Abstract］　Objective　To investigate the effect of acetylglutamide on anti-fatigue.Methods　With the weight carrying for swimming as motor model, the acetylglutamide were used in the mice by superalimentation for 21 days. The time of tolerate hypoxia and exhausting swimming, hemoglobin, blood lactate and blood urea nitrogen after determining charge were measured respectively.Results　The results showed that acetylglutamide could obviously prolong the time of exhausting swimming and tolerrate hypoxia, increase hemoglobin, decrease blood lactate and blood urea nitrogen level after determining intensity.Conclusion　 Acetylglutamide can improve the sport capacity.]]> 2018/10/22 8:14:38 HE Xian-guang 577true ［Abstract］　Objective　To investigate the clinical efficacy of root canal preparation by the combination of sonic endodontic instrument and hand K- file for infected molar root canals.Methods　One hundred and fifty-five molars of 129 chronic infected cases were randomly assigned to two groups and were prepared with step-back technique and disinfected by using calcium hydroxide paste as an interappointment medicament, experiment group（76 molars, 163 root canals）were prepared by sonic endodontic instrument MM1500 unit and hand K- file; control group（79 molars, 168 root canals）were prepared only by stainless steel hand K-files. The quality of root canal obturation，the incidence of EIE and the numbers of treatment sessions between two groups were compared.Results　There were significant difference of the numbers of treatment sessions between two groups，experiment group was less （P<0.05）, but no statistical significant differences of the quality of root canal obturation and the incidence of EIE between two groups （P > 0.05）.Conclusion　The combination of sonic endodontic instrument and hand K- file for infected molars root canals can reduce the numbers of treatment sessions，and be worth of clinical application.]]> 2018/10/22 8:14:38 LI Shi-jian, CHEN Yan, LU Zhao-wei, et al. 576true ［Abstract］　Objective　To investigate the clinical effect of fasudil hydrochloride on delayed cerebral vasospasm after subarachnoid hemorrage.Methods　Fifty-five patients were randomly divided into 3 groups: nimodipine group(n=15), fasudil group(n=20) and drugs combination group(n=20). Transcranial Doppler was performed at 3, 7, 14, 21, 28 days after onset.Blood pressure and Glasgow outcome scale were also evaluated.Results　Cerebral vasospasm were relieved and outcome were improved in the three groups, and there was no statistic difference among them.But incidence rate of low blood pressure in fasudil group was lower than that in both drug combination group and nimodipine group.Conclusion　The effect of fasudil hydrochloride on delayed cerebral vasospasm after subarachnoid hemorrhage was equivalent to nimodipine. The effect of fasudil-nimodipine combination were not enhanced.The influence of fasudil hydrochloride on blood pressure is lighter than nimodipine.]]> 2018/10/22 8:14:38 ZHANG Jin-hua, ZHAO Yan, JING Hong-jian, et al. 575true ［Abstract］　Objective　To discuss the infection condition of cervix humanpapillomavirus(HPV) in women in the Yulin, provide the theory basis for preventing the HPV infection and preventing and treating cervical cancer.Methods　The special-purpose sampling brush for cervix cast-off cells which was produced by the Hong Kong Kaipu biotechnology Co.LTD was used to take the uterus cast-off cells to carry on the HPV examination in the Yulin′s 862 women, and the HPV-DNA subtypes were analyzed.Results　There were 165 women with HPV infection in 862 women cervix samples, the positive rate was 19.14%. And the HPV infection′s percentage of the 19～30 -years -old group was 19.44%;the 31～45 -years- old group′s was 18.60%;the 46～70- years-old group′s was 20.45%, the HPV infection′s differences were not evident among the various age groups. The HPV′s distributing condition showed, there were 18 kinds of subtypes, 214 case-times, the high-risk subtype accounted for 73.36%.There were 12 high-risk subtypes (including HPV16, 18, 31, 33, 35, 39, 45, 51、52, 58, 59、68), 157 case-times, the first place of HPV high-risk subtype was HPV16, which accounted for 27.39%, other subtypes were as followings: HPV52 accounted for 26.11%;HPV58, accounted for 14.01%;HPV18, accounted for 10.83%; HPV31, accounted for 3.18%. There were 6 low-risk subtypes (including HPV11, 43, 53, 6, 66, CP8304), 57 case-times, accounted for 26.63%. Conclusion　The high-risk HPV infection is the etiology factor inducing cervical cancer, and screening, controlling the HPV infection can reduce the cervical cancer′s incidence rate effectively.]]> 2018/10/22 8:14:38 LUO Yu-di, DENG Guo-sheng 574true ［Abstract］　Objective　To research the effect of simvastatin on lipid-lowing, blood pressure and C-reactive protein. Methods　Sixty-eight patients with essential hypertension in Liuzhou Tumor Hospital from February 2007 to February 2009 were randomly selected, including 46 males and 22 females with an average age of (66.2±7.6). The study group with 34 patients was given simvastatin on a basis of perindopril and amlodipine besylate, the control group was given perindopril and amlodipine besylate, the change of lipid, blood pressure and C-reactive protein were observed after 4 weeks. Results　The total cholesterol, triglycerides, low density lipoprotein and cholesterol of the patients in treatment group were much lower than that in control group, the decreased degree of blood pressure and C-reactive protein of the patients in treatment group were much lower than that in control group. Conclusion　Simvastatin could reduce the blood pressure and serum C-reactive protein of the patients with essential hypertension.]]> 2018/10/22 8:14:38 YANG Ping 573true ［Abstract］　Objective　To investigate the effect of lipid abnormality and lipid -medulating therapy on monocyte adhesion molecules expression in patients with atherosclerosis.Methods　Thirty patients with unstable angina(UA) and 30 normal controls were enrolled in this study. After 3 months of treatment, the percentage of CD11a, CD11b and CD18 positive monocytes were measured. The levels of serum P-selectin, ICAM-1 and Ox-LDL in these patients before and after treatment with XZK were determined. Then relavent correlations were further studied.Results　Serum Ox-LDL levels significantly increased in patients with UA and positively correlated with serum P-selectin. Meanwhile there were also positive relationships between LDL and CD11a, CD18. Furthermore, after lipid-modulating therapy, with decrease of serum TC and LDL-c, the serum P-selectin, ICAM-1 and Ox-LDL levels were also decreased significantly, which suggested XZK could prevent inflammatory reaction of atherosclerosis, improve the function of vascular endothelial cells and delay the process of coronary artery atherosclerosis.Conclusion　XZK could decrease Ox-LDL induced adhesion molecules expression, which may be its another anti-atherosclerosis mechanism independent of lipid- modulating role.]]> 2018/10/22 8:15:02 DONG Yu-jiang, WANG Ping 572true ［Abstract］　Objective　To investigate the relationship between lipid metabolism and carotid atherosclerosis in essential hypertensive patients.Methods　The total cholesterol(TC), triglyceride(TG)，HDL-C, LDL-C, ApoA, ApoB, lipoprotein-a were tested and carotid artery ultrasonography were undergone in 122 essential hypertensive patients (observed group) and 34 normotensive persons (control group).Results　Compared with control group, the intima-media thickness was thicker, the number of atherosclerotic plaques was larger and the level of TG，LDL-C, ApoB, lipoprotein-a were higher in observed group.Conclusion　Abnormal lipid metabolism is related to the intima-media thickness and formation of plaque in hypertensive patients. Timely detecting the level of blood lipid and degree of carotid atherosclerosis, and evaluating the degree of patholoic change has important effect in early preventing and treating for hypertensive patients.]]> 2018/10/22 8:15:02 WANG Rong-gui, LIANG Hao 571true ［Abstract］　Objective　To explore the risk factors of hospital acquired pneumonia in neurological ICU patients, and to provide the corresponding clinical prevention strategies.Methods　The clinical data of all the 194 patients admitted to our neurological ICU from November 2007 to October 2008 were retrospectively investigated, of them 138 patients complicated with pneumonia as the case group, 56 patients without complications of pneumonia as the control group. A total 16 factors, including the age, sex, days of hospital stay ect, were collected for single-factor analysis and Binary Logistic regression analysis.Results　The single-factor analysis showed that the number of hospital days, indwelling stomach tube, indwelling urinary catheter, artery and vein cannulation, tracheal intubation or tracheostomy, invasive mechanical ventilation, and coma were related to acquired pneumonia. Logistic regression determined the number of hospital days, indwelling stomach tube were the risk factors for hospital acquired pneumonia.Conclusion　The internal and external environment factors lead to acquired pneumonia of neurological ICU patients.]]> 2018/10/22 8:15:02 JIANG Hong-liang, SHEN Yue-fei, LUO Jie-feng 570true ［Abstract］　Objective　To observe the effect of primary pterygium treated by improved pterygium excision with mitomycin-C.Methods　One hundred and thirty-one eyes were randomly divided into two groups.Seventy-three eyes were treated by improved pterygium excision with mitomycin-C in group A, fifty-eight eyes were treated by simple pterygium excision with mitomycin-C in group B. All surgery had been done by the same doctor. The patients had been followed up for 1～2 years.Results　The rate of complication in group A was lower than that in group B(P<0.05). The recurence rate was 6.3% in group A(4 eyes).The recurence rate was 17.2% in group B(10 eyes).The diferences were statistical significance between two groups(P<0.05).Conclusion　The method of improved pterygium excision with mitomycin-C can decrease the recurence rate and complication. It is a simple method of pterygium surgery.]]> 2018/10/22 8:15:02 ZHONG Hai-bin, LI Min, ZHAO Xin 569true ［Abstract］　Objective　To investigate the amplication ratio of panoramic radiograph.Methods　Fifty cases were examined with panoramic radiograph before implant placement, during which steil balls with 5mm diametter were placed in the edentulous area. Then diameter of the steil balls in the X ray film was measured and amplication ratio were calculated.Results　The mean of the amplication ratio in the vertical direction was 24.51%, and the frequency distribution table showed most of the value was in 20%～24%. No obvious distribution was observed.Conclusion　The amplication ratio of the vertical direction is relatively stable and similar to the innate amplication ratio. But 16% of the cases shows more deviation.]]> 2018/10/22 8:15:02 TANG Li, CHEN Dong-hui 568true ［Abstract］　Objective　To explore changes of serum cystatin C in neonate with hyperbilirubinemia, and evaluate its effect on function of glomerular filtration.Methods　Serum cystatin C, blood urea nitrogen(BUN) and creatinine(Cr) of neonates in hyperbilirubinemia group and of neonates in the control group were measured by enzyme-linked immunosorbent assay (ELISA).Results　There were no significant difference in serum BUN and Cr levels between the hyperbilirubinemia group and the control group.Serum Cys C levels in the hyperbilirubinemia group were significantly higher than those in the control group(P <0.01).When serum hyperbilirubinemia levels was decreased, serum Cys C levels was decreased too.Conclusion　Serum Cys C can be considered as a marker of damage function of glomerular filtration of hyperbilirubinemia neonates.]]> 2018/11/7 8:22:37 LI Shu-jun, TANG Cheng-he, ZHANG Jian 567true ［Abstract］　Objective　To observe the effect of locking compression plate on treatment of complicated fractures near extremity joint.Methods　One hundred and fifty-two cases of complicated fractures near extremity joint underwent internal fixation with locking compression plate, which were classified into B₁ type (18 cases), B₂(22 cases), B₃(35 cases), C₁(28 cases), C₂(29 cases) and C₃(20 cases) according to AO typing. All the clinical data were analyzed retrospectively.Results　One hundred and fifty-two cases were followed up for averaging (12.1±2.3) months. All fractures were healed without plate loosening or breaking. The results were excellent in 105 cases, fine in 33, fair in12, and poor in 2, with the total excellent and fine rate being 90.8%.Conclusion　Internal fixation with locking compression plate for treatment of complicated fractures near extremity joint was effective and feasible. It provided a simple operation with advantages of solid fixation, early fracture healing and functional recovery.]]> 2018/11/7 8:22:37 YANG Qing-da, SU Rui-jian, LIANG Bo, et al. 566true ［Abstract］　Objective　To investigate the scan skills and diagnostic methods in assessment of perforating veins of lower extremity with varicosity using color Doppler ultrasound(CDU). Methods　Thirty-three patients with varicosity of lower extremity were routinely detected by Logiq 700 ultrasound system with the 5～10MHz linear transducer before operation. The perforating veins were completely evaluated, including location, extension, size and valvula function.Results　One hundred and fifty-one incompetent perforating veins were found in 33 patients. Most of the perforating veins were located in calf (82%) and only 18% in thigh. All of the incompetent perforating veins found in CDU were confirmed in operation. Compared with the operation, 83% perforating veins were demonstrated by CDU.Conclusion　CDU can demonstrated most of incompetent perforating veins of lower extremity with varicosity. It is a simple and non-invasive technique for accurate diagnosis of incompetent perforating veins of lower extremity with varicosity.]]> 2018/11/7 8:22:37 ZHANG Bu-lin, HUANG Li, XIE Xiang-bo, et al. 565true ［Abstract］　Objective　To explore the value of lumbar disc microendoscopic discectomy (MED)when the lumbosacral nerve root anomaly occurred.Methods　Five hundred and sixty cases of lumbar discs herniation were treated with MED.In which 16 case of nerve root anomalies were found. The incidence was 2.8%.There were type Ⅱ10 cases, type Ⅲ 1 case and type Ⅳ 5 cases according to Kadish type. There were 6 cases at L4.5, 9 cases at L5S1 and 1 cases between L4.5 and L5S1.Sixteen cases of nerve root anomalies were operated by MED.Results　No nerve root injury happened in these 16 nerve root anmalies cases post MED.Preoperative symptoms and sings disappeared and no cases of recurrence were found by follow-up.Conclusion　There is a low incidence of the lumbosacral nerve root anomalies.There is a clearly identifying under MED, it could effectively prevent the nerve root injury because of its distinct vision and adjacent relationship between protruding disc and nerve root and anomaly nerve root. There were no special complications.]]> 2018/11/7 8:22:37 LI Hong-yu, LIANG Bin, YIN Dong, et al. 564true ［Abstract］　Objective　To investigate the rational therapy in treatment of tubal pregnancy.Methods　Data of 110 cases with tubal pregnancy from August 2007 to January 2009 were studied retrospectively. Three treatment methods were given included Chinese medicinal herbs, conservative surgery and radical surgery.Results　Intrauterine pregnant rate was16%, 47.83%, 10.87% in medicine therapy, conservative surgery, and radical surgery, respectively, which significant difference among three groups. Recurrent ectopic pregnant rate among three groups was no statistically significant.Conclusion　Conservative surgery is suitable for the young women who hope to preserve fertility; radical surgery is suitable for the women who have no hope to preserve fertility or with bulky lesion; Chinese medicinal herbs has no trauma and is cheap and has a long follow-up.]]> 2018/11/7 8:22:37 LIU Jiu-ying, MA Gang, Wang Lin 563true ［Abstract］　Objective　To investigate the method of early enteral nutrition in the upper digestive tract injury induced by chemical burn. Methods　The clinical data of early enteral nutrition with liquid capsule jejunum catheter for the 16 cases of upper digestive tract injury induced by chemical burn in the past 5 years were retrospectively analyzed. Results　Liquid capsule jejunum catheter was soft and thin, and the early application of liquid capsule jejunum catheter for establishment of early enteral nutrition access in upper digestive tract injury induced by chemical burn was valuables, without bleeding or perforation. Conclusion　Early enteral nutrition with liquid capsule jejunum catheter in upper digestive tract injury induced by chemical burn is safe and feasible.]]> 2018/11/7 8:22:37 SU Jun-kai, ZHANG Ming-qing, WANG Ai-min, et al. 562true ［Abstract］　Objective　To explore the defecation feasibility of laparoscopic extraperitoneal colostomy in patients with advanced stage rectal cancer.Methods　The clinical data of 21 cases of advanced stage rectal cancer received laparoscopic extraperitoneal colostomy from June 2006 to May 2008 were analysed retrospectively.Results　All the 21 cases received laparoscopic extraperitoneal colostomy successfully without conversion.Conclusion　The laparoscopic extraperitoneal colostomy is safe and feasible in the patients with advanced stage rectal cancer to solve the problem of defecation.]]> 2018/11/7 8:22:37 TAO Xu-xiong, Ye De-qiang, YU De-yuan, et al. 561true ［Abstract］　Objective　To study the outcome of hypertensive intracranial hemorrhage treated by stereotactic methods in ultra-early stage.Methods　Sixty-six patients with hypertensive intracranial hemorrhage were divided into two groups: ultra-early group (34 cases) and early group (32 cases). Hemorrhagic masses were evacuated by stereotactic methods. The outcome between two groups was compared.Results　In ultra-early group, 4 cases were dead.And 28 cases were followed-up, good in 5 cases, moderate disability in 18 cases, severe disability in 4 cases, and vegetative stage in 1 case. In early group, 3 cases were dead. And 27 cases were followed-up, good in 3 cases,moderate disability in 12 cases, sever disability in 11 cases, and vegetative stage in 1 case. The comparison of good- moderate disability rate and severe disability rate between two groups showed the treatment effect of the ultra-early group was better than that of early group（u^c=2.015,P<0.05).Conclusion　Better outcome might be achieve by ultra-early evacuation with stereotactic method for hypertensive intracranial hemorrhage.]]> 2018/9/10 8:34:49 LIU Gui-biao,HUANG He-qing,CHEN Jia-kang,et al. 560true ［Abstract］　Objective　To study the middle and long-term efficacy and side effects of traditional Chinese medicine in the treatment of antipsychotic drugs(AP)-induced amenorrhea in female schizophrenic patients.Methods　One hundred female schizophrenic patients with antipsychotic drugs -induced amenorrhea whose menstruation were interrupted more than 3 months were randomly divided into two groups with 50 patients in each group. The treatment group was treated with traditional Chinese medicine for 6 months and the control group was treated with artificial menstrual cycle therapy.Results　There were no significant difference between two groups after 3 months treatment (P>0.05), the efficacy of study group was better than that of the control group after 6-months of treatment (P<0.05).Conclusion　Traditional Chinese medicine has better efficacy and fewer side effects for treating amenorrhea caused by antipsychotic drugs in female patients with schizophrenia.]]> 2018/9/10 8:34:49 SHI jie，TAO Jian-qing，LIANG Jia, et al. 559true ［Abstract］　Objective　To evaluate the efficacy of amphotericin B in the treament of penicilliosis marneffei patients with nephropathy,in order to improve the level of safe clinical drug application.Methods　Three penicilliosis marneffei patients with nephropathy were treated with amphotericin B,and their hepatic renal function before and after treatment were compared; the treatment efficacy and adverse reaction were evaluated.Results　After treatmnt,all three patients showed in improvement clinic symstom.The infection-related liver function damage also were improved.The adverse reaction included hypokalemia and fatigue ect.,but no severe side reation were found.Conclusion　Amphotericin B may be an effective and contollable drug in treating penicilliosis marneffei patients with nephropathy.]]> 2018/9/10 8:34:49 YANG Zheng-teng,CHEN Xiao-yu,LI Hui,et al. 558true ［Abstract］　Objective　To evaluate the clinical significance of expression of vascular endothelial growth factor(VEGF) expression in the treatment of cervical cancer by artery chemoembolization combined with preoperative intracavitary brachytherapy(IB).Methods　Fifty-one patients with cervical cancer were treated between August 2000 and November 2007.Twenty-six patients were performed bilateral uterine artery embolization after uterine artery injection of chemotherapeutic agents, IB were underwent in 12 of 26 patients.Twenty-five patients were infused chemotherapy drugs by bilateral internal iliac artery transcatheter, IB were undergone in 10 of 25 patients.All patients were treated by carboplatin-based combination chemotherapy. and then radical hysterectomy and pelvic lymphadanectomy was performed 2 weeks after interventional therapy or IB. VEGF expression were observed by immunohistochemical methods on a total of 102 cervical cancer specimens before and after the treatment.Results　The positive expression of VEGF in cervical cancer was dropped from 64.7% preoperation to 45.1%, the difference was significant.Preoperative positive expression of VEGF was significantly correlated with FIGO stage, tumor grade and pathological response. The clinical response after arterial chemoembolization followed by preoperative IB in patients with positive expression of VEGF(54.5%, 18/33) was lower than those with negative VEGF expression (77.8%, 14/18), but the difference was not statistically significant (P= 0.105). The 5-year overall survival and disease-free survival rates in patients with negative expression of VEGF before treatment were higher than those with VEGF positivity (100%, 94% vs. 73%, 75%, P= 0.043, P= 0.112), overall survival rate difference was statistically significant.Conclusion　The study indicates that VEGF expression before treatment may serve as clinical response and prognosis predictors in patients with cervical cancer who receive artery chemoembolization combined with preoperative IB.]]> 2018/9/10 8:34:49 YU Lei,YANG Jian-yong,XIANG Xian-hong,et al. 557true ［Abstract］　Objective　To analyze the relationship between adiponectin and the cardiac and cerebral angiopathy in the patients with type 2 diabetes mellitus (T2DM). Methods　There was three groups： 35 examined healthy persons were enrolled in this study as control group (group A); the group B was composed of the diabetic patients without macroangiopathy(n=42); the group C was composed of the diabetic patients with the cardiac and cerebral vascular complication (n=38). Their serum adiponectin(ADP), blood glucose,blood lipid,fasting inlusin were determined. The insulin resistance index (IRI) was calculated. The carotid intima-media thickness(CIMT) was measured. The results were analyzed. Results　(1)The level of serum adiponectin of group B was lower than that of group A (P<0.01), Group C had the lowest level of adiponectin among 3 groups (P<0.01). The patients in group B and C had more evident metabolic disturbance and insulin resistance than group A. (2) ADP was negatively correlated with CIMT (P<0.01).(3) Multiple linear stepwise regression analysis suggested that decrease of adiponectin and high-density lipoprotein cholesterol and the increase of triglycerides were the dangerous factors of CIMT thickening. Conclusion　Lower adiponectin concentration is one of the independent dangerous factors for atherosclerosis in the type 2 diabetes patients. It can improve insulin resisitent, regulate blood glucose and blood lipid, lower blood pressure, slow down the atherosclerosis of diabetes， protect the patients with type 2 diabetes against the cardiac and cerebral vascular disease.]]> 2018/9/10 8:35:16 XUN Jing-qiong, SU Ke,LONG Yan,et al. 556true ［Abstract］　Objective　To study the effect of the insulin intensive therapy on the inflammatory factors and apoptosis in diabetic rabbit′s brain tissue.Methods　Homemade rabbit diabetes mellitus models induced by alloxan were divided into 3 groups according to the different insulin infusion programs: A group received multiple subcutaneous injection of insulin, B group adopted isophane protamine biosynthetic human injection (pre-mixed 50R), C group received isophane protamine biosynthetic human injection (pre-mixed 30R).D group(untreated group) and N group(control groups). The therapy period was 30 days. The insulin dose and period at the targeted blood glucose level among 3 insulin groups were recorded.The blood glucose levels,body weight,TNF-α,IL-6,the rate of apoptosis of the pyramidal cells by dTdT mediated duTP rick end-labeling (TUNEL) and pathohistology change in the parietal lobe of the brain by hematoxylin-eosin dyeing (HE) were observed.The values inspected were compared to those of untreated group and control groups.Results　Insulin dose(5.62±0.67)U/kg of B group is less than A group and C group. C group used the largest amount of insulin to get to the targeted blood glucose levels. There was significant difference among treated groups(P<0.01). the period was shortest in A group (7.00±1.31) days and longest in C group(19.63±1.41) days.There was significant difference among treated groups(P<0.001). At the end of the investigation, the body weight was negatively related to the blood glucose(r=- 0.559, P<0.01), IL-6 and TNF-α were positively related to the blood glucose (r=0.751、 0.799, P<0.001). The water content of the brain、 TNF-α were significant difference among treated groups(P<0.05). Most of the neurons were degenerate and apoptotic in untreated group, the rate of apoptosis was (26.67 ± 0.99)%, There was significant difference among 3 groups (P<0.01). Conclusion　Diabetes mellitus can increase the expression of inflammatory cytokines in diabetic rabbit′s brain tissue and promote the pyramidal cells apoptosis. Intensive insulin therapy can relieve the apoptosis and inflammatory reaction in the diabetic rabbit′s brain. Subcutaneous injection of pre-mixed 30R may be the optimal insulin regimen.]]> 2018/9/10 8:35:16 ZHONG Mei,LI Ni,CHEN Hui,et al. 555true ［Abstract］　Objective　To evaluate the impact of rehabilitation therapy on poststroke depression and deformity in the patients with stroke.Methods　We evaluated 122 consecutive patients with stroke(90men,32 women; aged( 64±10) years enrolled in rehabilitation therapy from July 2006 to January 2009.Depressive symptoms were assessed by HAMD questionnaire and neural functional impairment was evaluated by NIHSS before and after rehabilitation therapy.Results　Depressed patients had higher neural functional impairment than nondepressed patients (P<0.0001).Prevalence of depressive symptoms significantly decreased after rehabilitation therapy, from 17% to 6%(P<0.0001). Similar reductions in depressive symptoms and its associated deformity were related to rehabilitation therapy.Conclusion　These findings indicate that depression is a frequent companion of stroke, and rehabilitation therapy is helpful in improving depressive symptoms and the deformity.]]> 2018/9/10 8:35:16 LI Lei-li,MA Li-ping 554true ［Abstract］　Objective　To evaluate the clinical features and perinatal outcome of early-onset preeclampsia (PE). Methods　A retrospective analysis of 524 cases of preeclampsia from January 2004 to December 2009 was performed. All the patients were divided into two groups according to gestational week: early-onset preeclampsia group (<32 weeks) and lately-onset preeclampsia group (≥32 weeks). The data were analyzed on the incidence，manifestation， maternal and fetal complications. Results　Compared with the lately-onset preeclampsia group, the early-onset preeclampsia group had significant family history of hypertension and preeclampsia (P<0.01); easily developed into severe preeclampsia and renal dysfunction and hepatic dysfunction (P<0.01); had high perinatal mortality (P<0.01); The gestational time at delivery was significantly correlated with perinatal prognosis (P<0.05). Conclusion　Early-onset preeclampsia is a severe type of preeclampsia, which has high perinatal mortality.]]> 2018/9/10 8:35:16 HUANG Ling-ling, ZHONG Lin-lin, SU Sha 553true ［Abstract］　Objective　To explore the clinical curative effect of laparoscopic total mesorectal excision(TME) for rectal cancer.Methods　From September 2005 to December 2009，84 patients with rectal cancer received laparoscopic TME were analyzed retrospectively.Results　The TME were successfully completed by laparoscopic approach in 82 patients，and 2 patients was converted to open procedures.The operation time was 164(115～280）min. Operative blood loss was 77.1(30～200）ml.The bowel function was returned 1～2 days after operation.Average hospital stay was 9.1（6～15）d.Postoperative anastomotic leakage occurred in 2 patients and pulmonary infection in 3 patients. The patients were followed up for from 1 months to 4 years，no reccurrence was found after operation.Conclusion　Laparoscopic TME for rectal cancer is an excellent minimally invasive technique.It has advantages such as less trauma，less bleeling，and rapid postoperative recovery.]]> 2018/9/10 8:35:16 ZHAI Dong-sheng 552true ［Abstract］　Objective　To compare the effect of propofol combined with different opioid drug anesthesia on the pain-free gastroscopy.Methods　Two hundred and fourty ASAⅠor Ⅱpatients aged 25～60 years weighing 45～75 kg were randomly divided into 4 groups(n=60): group P received propofol 1～2.5 mg/kg;group F received fentanil 0.8 μg/kg;group S received suffentanil 0.08 μg/kg; group R received remifentanil 0.5 μg/kg slowly iv.Lidocaine 20 mg and propofol 1～2 mg/kg were then injected slowly iv except group P until consciousness was lost and eyelash reflex disappeared. Gastroscopy was started when the consciousness disappeared.Intermittent iv boluses of propofol 0.5～1 mg/kg were given during operation when necessary. The total dosage of propofol used for induction,awakening time, the score of VSA were observed.The level of pain at awaking and at 1 hour after awaking,and side effects were evaluated.Results　The total dosage of propofol used for induction was significantly lower in group R,group F and group S than that in group P （P<0.05）;the total dosage of propofol used for induction was significantly lower in group R than group F and group S （P<0.05）. The rate of hypoxemia was increased in group R than group F and group S （P<0.05）;The awaking time was shorter and visual simulation score at awaking was lower in group F,group S and group R than in group P. There were no significant differences in awaking time and visual simulation score at awaking in other groups except group P;the VSA at 1 hour after awaking in group S was lower than group F and group R （P<0.05）.Conclusion　The total dosage of propofol used for induction is lower in propofol combined with different opioid drug anesthesia than single uea propofol in the pain-free gastroscopy, the total of propofol used for induction is lower in 0.5 μg/kg remifentanil group than in 0.8 μg/kg fentanil group and 0.08 μg/kg suffentanil group，the rate of hypoxemia was increased in group R than group F and group S.]]> 2018/9/10 8:35:16 DING Ling-ling 551true ［Abstract］　Objective　To discuss the related factors of refractive regression after LASIK in myopia.Methods　Sixty-nine eyes were retreated for the refractive regression after LASIK. They were divided into 4 groups by their myopia diopter. The data of the patients and the operation were recorded and compared statistically.Results　The rates of the regression among the 4 groups had significant differences and the degree of the regression had significant differences also. Higher myopia diopter before the surgery, higher degree of refractive regression after LASIK.Conclusion　There is the relationship between the refractive regression diopter after the LASIK and original myopia diopter.]]> 2018/9/17 8:12:27 SONG Qiang， LU Lin-de，WU Shang-guo 550true ［Abstract］　Objective　To determine the necessity and feasibility of blood compatibility test for emergency patients treatment before blood transfusion.Methods　A retrospective analysis of the percentage of emergency patients′ transfusion and the situation of blood compatibility test of emergency patients before transfusion in four 3 A grade hospitals were performed.Results　There were 746501 emergency patients in the four hospitals, which included 1848 applicants and 920 users in transfusion, separately accounted for 0.25% and 49.78%. The items of blood compatibility test before transfusion were perfect in the hospitals. Transfusion compatibility tests were accomplished accurately before sending out blood.Conclusion　It is very necessary and feasible that rapid and effect tests are jointly applied before emergency patients receiving blood transfusion.]]> 2018/9/17 8:12:27 JIAO Wei, LI Hai-lan, WANG You-xin, et al. 549true ［Abstract］　Objective　To analyze diagnosis,treatment and prognosis of 11 cases of solid-pseudopapillary tumor of pancreas(SPTP).Methods　The clinical data of 11cases of SPTP were analyzed retrospectively.Results　There were no specific clinical symptoms in all patients and abdominal pain and space occupying were the mostly symptoms.Nine cases recieved fine-needle aspiration biopsy;of them preoperative diagnosis of 4 cases were correct.All the cases were received operation. Eight cases recovered successfully after operation;one case received nonstandard pancreatic resections suffered from postoperative pancreatic fistiula and was cured by conservative treatment;one case recurred and was cured by the second operation.Conclusion　The correct preoperative diagnosis can be obtained by histologic finding and immunohistochemisty.Complete surgery could get good prognosis.]]> 2018/9/17 8:12:27 LONG Di,GUO Ya,BI Yong-hao,et al. 548true ［Abstract］　Objective　To investigate the effect of vacuum sealing drainage(VSD) technique on the management of severe skin and soft tissue defects. Methods　One hundred and twenty patients with severe skin and soft tissue dirty defects were divided in two groups,VSD group was treated by the VSD technique(60 patients) and the control group(60 patients) was managed by traditional method. Results　In VSD group, wound surface treatment time were 6～12 d with an average of (7.6±1.5)d, skin graft were performed in 45 patients, flap repair in 15 patients; in control group, wound surface treatment time were 12～20 d with an average of (15.6±4.3)d, skin graft in 32 patients, flap repair in 28 patients, there were significant differences in times of treatment, the total time of hospitalization between two groups(P<0.01). And there was a significant difference in curative effect of skin grafting between two groups(P<0.05). Conclusion　VSD is superior to the traditional dressing charge for curing the skin and soft tissue detect.]]> 2018/9/17 8:12:27 GAN Feng-ping,JIANG Jian-zhong,TAN Hai-tao 547true ［Abstract］　Objective　To explore the effect of prophylactic application of amiodarone in emergency treatment of patients with sudden cardiac death and its safety.Methods　Thirty patients with sudden cardiac death were randomly divided into two groups: amiodarone prophylactic application group and routine treatment group with 15 patients in each group. The times of defibrillation and cases of death and adverse reaction were statistically analyzed.Results　The times of defibrillation were (1.3±0.1) in amiodarone prophylactic application group and (4.86±0.5) in routine treatment group (P<0.01). The death rate were 40% in amiodarone prophylactic application group and 80% in routine treatment group (P<0.05). Adverse reactions were observed in 2 patients in amiodarone prophylactic application group.Conclusion　Prophylactic application of amiodarone in emergency treatment of patients with sudden cardiac death can significantly decrease the utilization rate of defibrillator, increase the rate of successful rescue with no severe adverse reaction.]]> 2018/9/17 8:12:27 HE Xian-guang, LIU Zhao-hong, NI Xiao-qing 546true ［Abstract］　Objective　To explore the method and effect of hepatectomy for the treatment of the patients with hepatolithiasis.Methods　Retrospective summary was made on 256 patients with hepatolithiasis undergone different types of hepatic lobectomy from December 1996 to December 2006.Results　None of patients died in operation. The postoperative complications included biliary fistulas (12 patients, 4.69%), subphrenic infection (7 patients, 2.73%), peritoneal abscesses (5 patients, 1.95%) and liver failure (2 patients, 0.78%). Long-term follow-up was performed in 229 patients. The follow-up time ranged from 4 months to 10 years with an average of 7 years and 3 months. The results showed that 93.01% of patients were without symptom and could work and live normally; 5.68% of patients had occasional mild attacks of cholangitis; 1.31% of patients had severe cholangitis requiring further surgical intervention.Conclusion　Hepatic lobectomy is one of the most effective treatments for hepatolithiasis.]]> 2018/9/17 8:13:20 ZHANG Qi-shun, HUANG Shi-feng, LIU Lei, et al. 545true ［Abstract］　Objective　To evaluate the efficacy of ultrasound guided kneading and compression in the treatment of post-PCI femoral artery pseudoaneurysms. Methods　Eight patients with post-PCI femoral artery pseudoaneurysms underwent kneading and compression treatment with a convex probe GE HEALTHCARE. Results　All femoral artery pseudoaneurysms were successfully treated in one time, the average time of kneading and compression is ten minutes. Conclusion　Ultrasound guided kneading and compression treatment is a simple, effective, safe methods for the treatment of post-PCI femoral artery pseudoaneurysms.]]> 2018/9/17 8:13:20 DENG Jin-long, LAN Chun-yong, WU Yin-xiong, et al. 544true ［Abstract］　Objective　To investigate the relationship between small airway obstruction and early lung adenocarcinoma in non-smoking women,and the correlation between environment exposure and small airway obstruction.Methods　A case-control study was carried out.There were 85 female patients diagnosed as lung cancer group and the control group included 85 healthy volunteers.Pulmonary function tests were used to evaluate small airway function.Results　There was a significant difference in pulmonary function test indexes FEF50%,FEF75%,MMEF75/25 between lung cancer group and control group（P<0.01）,above indexes in control group was higher those in lung cancer group.Passive smoking was related with small airway obstruction in patients with lung adenocarcinoma［adjusted relative risk (adjusted RR)=3.55, 95%confidence interval(95%CI)=1.33～9.02］.Cooking oil exposure(adjusted RR=3.61, 95%CI=1.78～9.13) had higher risk of small airway obstruction than no exposure(adjusted RR=1.90,95%CI=0.84～4.03).Conclusion　Small airway obstruction is associated with early lung adenocarcinoma in non-smoking women. Passive smoking and cooking oil exposure are risk factors of small airway obstruction.]]> 2018/9/17 8:13:20 ZHANG Jin-hui, WANG Zhen-shan, WANG Qi,et al. 543true ［Abstract］　Objective　To investigate the clinical features of isolated noncompaction of ventricular myocardium (NVM).Methods　Clinical manifestations of 11cases of NVM were reviewed and the features of assisted examination such as echocardiogram, X-ray, electrocardiograph and so on were discussed.Results　More patients revealed left heart failure and then ventricular arrhythmia.Conclusion　NVM has a long-term clinical course and diversified manifestations which usually result in misdiagnosis, while echocardiogram is important in diagnosis and screening.]]> 2018/9/17 8:13:20 HU Chang-xing, ZHAO Y-ilan, XU Guang-ma, et al. 542true ［Abstract］　Objective　To expore the relationship between the related factors and pulse pressure(PP) of the elderly patients with essential hypertension (EH). Methods　A retrospective investigation of 309 hospitalized patients with EH (male 185 cases, 124 cases of women) from 2003 to 2007 were performed, In accordance with PP≤60 mmHg, 60100 mmHg, the patients were divided into 3 groups. In each group,the correlation of PP with sex, hypertension course, body mass index (BMI), SBP, DBP, blood glucose, blood lipids, LVMI, EF, FS, carotid artery plaque were annalyzed. Results　There was no correlation of PP with the BMI, blood glucose, triglyceride (TG), cholesterol (TC), low density lipoprotein (LDL)(P>0.05); There were positive correlations of PP with age, hypertension course, SBP, LVMI, carotid artery plaque, EF(r=0.25, 0.23, 0.48, 0.65, 0.69, 0.31, P all <0.01), while there was negative correlation of PP with DBP, FS, high-density lipoprotein (HDL)（r=-0.90, -0.35, -0.22, P all <0.01). Conclusion　There is correlation of PP with age, duration of hypertension, SBP, DBP, EF, FS, HDL, LVMI, carotid artery plaque]]> 2018/9/28 10:50:38 LI Wei,XIA Hao,WANG Feng,et al. 541true ［Abstract］　Objective　To investigate the effect of sodium vanadate on cyclinD1 expression in human gastric cancer cell line SGC7901 and explore its potential mechanisms of inhibiting proliferation.Methods　Cell growth inhibition in vitro was evaluated with MTT assay in human gastric cancer cell line SGC7901. Western blot analysis was applied to determine modification of cyclinD1 proteins of human gastric cancer cell line SGC7901.Results　The expression of CyclinD1 was evidently decreased by sodium vanadate of certain concentration.Conclusion　Sodium vanadate inhibits the proliferation of human gastric cancer cell line SGC7901 significantly， the antitumor mechanism of sodium vanadate may be related to down-regulation of CyclinD1 expression.]]> 2018/9/28 10:51:43 HUANG Li-hua,LV Jun,PAN Xiao-ping,et al. 540true ［Abstract］　Objective　To investigate the serum levels of matrix metalloproteinase-9(MMP-9) and its specific inhibitor matrixmetalloproteinase-1(TIMP-1) in elderly patients with chronic ischemic nephropathy and their potential significance in pathogenesis. Methods　Serum MMP-9 and TIMP-1 levels were measured with ELISA in 30 patients with chronic ischemic nephropathy and 22 subjects in control group and the correlation with serum lipids and creatinine to be analyzed. Results　The serum MMP-9 and TIMP-1 level (346.9±14.3; 112.9±10.5）ng/ml in the nephropathy group were significantly higher than those in controls （91.6±7.5; 57.4±3.9）ng/ml （P<0.01）; the serum MMP-9 and TIMP-1 content ware positively correlated with serum total cholesterol（r=0.7231, r=0.6415, P<0.01）, but uncorrelated with creatinine. Conclusion　MMP-9 and TIMP-1 may be involved in the pathogenesis of chronic ischemic nephropathy and may be the indenpent risk factor in the progression of ischemic nephropathy.]]> 2018/9/28 10:51:43 ZHAO Hai-xia, WU Yu-mei, SUN Hui, et al. 539true ［Abstract］　Objective　To investigate the clinical situation, laboratory examination, chest radiology, pulmonary function in patients with polymyositis(PM)/ dermatomyositis(DM)-associated interstitial lung disease(ILD).Methods　Seven patients with PM/DM-associated ILD were observed, 5 male and 2 female of them, mean age was 55.7 years, and 5 patients were DM, 2 patients were PM. Serum enzyme and autoantibody were determined, high resolution CT (HRCT) scanning, pulmonary function testing, skin and muscle biopsy were taken in all patients.Results　The levels of creatine kinase (CK) and lactate dehydrogenase (LDH) increased significantly in six patients. Antinuclear antibody(ANA) was positive in four patients, and anti-Jo-1 antibody was positive in two patients. Skin and muscle biopsy indicated that pathology was in accord with PM or DM pathological characteristics in all patients; HRCT scanning showed that reticular and patching abnormalities in four patents, ground glass opacities and consolidation shadow in three patients. Pulmonary function testing showed that restrictive ventilatory functional disturbance, and diffusion capacity of the lung for carbon monoxide (DLCO) decreased significantly in all patients. After glucocorticoids and immunodepressant were used in six patients, five patient′s condition was stable, but one patient died.Conclusion　HRCT may find early pulmonary changes in PM/DM. CK level increase markedly and positive anti-Jo-1 antibody are important diagnostic indicators for PM/DM-associated ILD, and DLCO is decrease significantly in patients. Therapy with glucocorticoids and immunodepressant may make better curative effect.]]> 2018/9/28 10:51:43 LIANG Da-hua, WEI Cai-zhou, LONG Sheng-ze, et al. 538true ［Abstract］　Objective　To analysis the etiology, risk factors, clinical characteristics and prognosis of young patients with cerebral infarction.Methods　The clinical data were retrospectively analysed on 80 young patients with cerebral infarction, and 80 elderly patients with cerebral infarction were randomly sampled over the same period of hospitalization for comparative analysis.Results　There were 23 patients with atherosclerosis (28.75%),16 patients with hyperlipemia (20.0%), 18 patients with hypertension (22.5%)，and 2 patients with infection history（2.5%）in the young group,while they were 66 patients（82.5%），38 patients（47.5%），51 patients（63.75%）and no patients respectively in old group.There were significant differences between two groups(all P<0.01).Conclusion　The incidence rate in male was significantly higher than that in women, and prognosis is good. Like the elderly，hypertensive，arteriosclerosis, heart disease, diabetes, hyperlipidemia, transient cerebral ischemic attack(TIA), obesity, smoking and drinking are the main pathogenic and risk factors of young patients with cerebral infarction. Only to find the causes as soon as possible,control a variety of risk factors actively,and give adequate intervention,the incidence of cerebral infarction in young people can be effectively reduced.]]> 2018/9/28 10:51:43 SHANG Guan-wen 537true ［Abstract］　Objective　To explore the pathogenesis, diagnosis and treatment of centeral hyponatremia after severe brain injury.Methods　The data of 67 patients with central hyponatremia were analyzed retrospectively on clinical manifestations, laboratory examination, treatment and efficacy.Results　The patients of inappropriate secretion of antidiuretic hormone syndrome(SIADH) were treated with limited water intake and the patients of cerebral salt wasting syndrome(CSWS) with added salt. All patients with hyponatremia were corrected.Conclusion　There are two forms of central hyponatremia after severe brain injury: Inappropriate SIADH and CSWS. Therefore, there are two different therapeutic methods for centeral hyponatremia after severe brain injury.]]> 2018/9/28 10:51:43 SUN Zhi-yang, TANG Lun-xian, Xu Tao, et al. 536true ［Abstract］　Objective　To assess the data collected through the computerized system for reporting bacillary dysentery, providing information for developing improvement strategies.Methods　The electronic reports on bacillary dysentery derived from the online reporting system in Guangxi were analyzed using EXCEL and FOXPRO.Results　From 2007 to 2009, Guangxi reported 28 636 cases of bacillary dysentery. The rate was 95.19% from diagnosis to report form completion within 24 h 67.43% form completion to electronic reporting within 24 h.The rate of timeliness was 98.34% from electronic reporting to review by local epidemiologists. The proportion of laboratory confirmation was 16.50% (4 723/28 636), however, at township levels, it was only 6.44%. Conclusion　The online reporting system has improved the timeliness in disease reporting. There is a need to further improve guidelines for infectious diseases surveillance in order to enhance the abilities of laboratory confirmation and timely response to infectious diseases at various levels.]]> 2018/9/28 10:51:43 ZHANG Jie 535true ［Abstract］　Objective　To compare the effects of different anesthesia induction and tracheal intubation on circulatory system in elderly patients.Methods　Eighty elderly patients undergoing elective surgery were randomly divided into two groups, Ⅰ group were treated with amnesia induced slow analgesia method;Ⅱ group were treated with intravenous rapid induction method for endotracheal intubation general anesthesia. HR,MAP and SpO₂ at repose time(T₀), 2min after administration (T₁), before intubation (T₂), immediate intubation (T₃), 1 min after intubation (T₄), 3 min after intubation (T₅), 5 min after intubation (T₆) were recorded. The occurrence of adverse reaction were observed.Results　At T₀ MAP and HR in the two groups was no significant difference (P>0.05); when compared with T₀, MAP and HR at all time inⅠgroup was no significant difference (P>0.05); and compared with T₀,MAP at T_1～2 in Ⅱ group was lower (P<0.05); when compared with T₀, MAP at T_3～5 in Ⅱ group was higher (P<0.05); when compared with T₀, HR at T₂ inⅡ group was lower (P<0.05); and compared with T₀, HR at T_3～5 inⅡ group was higher (P<0.05); compared with group Ⅰ,incidence of hypertension and tachycardia was higher（P<0.05). Conclusion　Compared with the rapid intravenous analgesia amnesia slow-induced analgesia method is more secure in the elderly patients, the impact on hemodynamics is small, with few complications.]]> 2018/10/8 8:27:44 DING Ling-ling,Jin Chao-hai,Zhang Hong,et al. 534true ［Abstract］　Objective　To observe the efficacy and advantages of TCM comprehensive therapy in treatment of simple obesity.Methods　Two hundred cases of simple obesity were randomly divided into four groups (comprehensive therapy group,herbal group, acupuncture and tuina group, catgut implantation group), with each group receiving a different treatment. The results were collated after 8 weeks.Results　The rate of effectiveness for the comprehensive therapy group was 92%, with the body weight, BMI and WHR improving after the treatments when compared with the other groups（P<0.05）, and with no significant side effects.Conclusion　TCM comprehensive therapy can significantly improve the treatment effectiveness in simple obesity without any significant side effects. Clinic compliance for this method is also very good，and it is suitable for long-term use.]]> 2018/10/8 8:27:44 HUANG Long-jian,JIANG Jun-ling,LV Yan 533true ［Abstract］　Objective　To investigate the relationship between the polymorphism of dopamine receptor D4 (DRD4) and primary osteoporosis in elder men in Fuzhou.Methods　In 70 aged male patients with osteoporosis and 70 healthy older men, the genotypes and alleles of DRD4 were detected and analyzed by using the polymerase chain reaction and gene sequencing techniques.Results　Osteoporosis genotype and allele frequency distribution of patients compared with healthy older men was no significant difference (respectively χ²=3.79，P>0.05；χ²=3.38，P>0.05).Conclusion　DRD4 gene could not be confirmed as candidate genes for primary osteoporosis in elderly men in Fuzhou region.]]> 2018/10/8 8:28:25 ZENG Yue-gui, CHEN Yan, YAO Jin, et al. 532true ［Abstract］　Objective　To evaluate the effects of the orthodontic treatment on the periodontal patients with tooth migration.Methods　Periodontal indices，X-ray analysis， model analysis，soft tissues analysis and questionnaire analysis were used.The changes of malocclusion and periodontal health before and after orthodontic treatment were compared.Results　The patients′ periodontal health were maintained;the overjet and overbite were decreased. The facial balance self-confidence were improved.Conclusion　Orthodontic treatment could correct the malpositioned teeth，maintain the periodontium conditions and gain the positive psychological effect for the patients.]]> 2018/10/8 8:28:25 LU Yu,HE Hong, WANG Zeng-quan, et al. 531true ［Abstract］　Objective　To study the clinical effects of using cervifix internal fixation system on upper cervical spine injuries.Methods　Twelve patients with upper cervical injuries were fixed using cervifix internal fixation system with autologous bone grafts,including 3 patients with old atlantoaxial dislocation,3 patients with acute atlantoaxial dislocation,2 patients with fracture of the dentoid process of axis，2 patients with fracture of C₂ vertebra and accompanied atlanto-axial incomplete dislocation,2 patients with fracture of C₂,C₃ vertebra.Graded by ASIA:A 2 patients, B 4 patients, C 5 patients, D 1 patient.Results　All patients were followed up postoperatively for 0.8～5 years, with an average of 2.7 years.All patients had solid osseous unions, the rate of fusion was 100%.There were no complications of lossening and rupture of the internal fixation rods and screws.Graded by ASIA:A 1 patients, B 2 patients, C 3 patients, D 6 patients, the recovery of paralysis was significant in post-operations（P<0.01）.Conclusion　Cervifix internal fixation can provide rigid stability of upper cervical injuries, the effect of fixation is well and the rate of fusion is high.]]> 2018/10/8 8:28:25 XU Shun-li,CAO Fei,ZHANG Fu-hua,et al. 530true ［Abstract］　Objective　To investigate the relationship between the efficacy and the karyotype and immunophenotype in acute lymphocytic leukemia (ALL). Methods　A total of 49 bone marrow samples were taken for the karyotype and immunophenotype analysis. Results　The detected rate of abnormal karycotype with t(9;22) in ALL children was significantly lower than that in ALL adult (P<0.05), but no difference in efficacy (P> 0.05); There was differences in efficacy between the abnormal karyotype with t(9;22) and normal karyotype (P<0.05); There was no difference in efficacy between acute lymphocytic leukemia with and without myeloid antigen expression (P> 0.05). Conclusion　There was a higher rate of abnormal chromosome karycotype in patients with ALL, the more common chromosomal abnormal karycotype was t(9;22). There was a relationship between chromosomal abnormal karycotype and the efficacy. The efficacy was poorer in chromosomal abnormal karycotype accompanied by t(9;22) in ALL, while there was no difference in efficacy between other abnormal karyotypes in ALL.]]> 2018/10/8 8:28:25 CHEN Zheng-li, NING Zi-jue, LIU Bo,et al. 529true ［Abstract］　Objective　To observe the effect of high glucose on the expression of TGF-β1 in primary cultured human mesangial cells，and to elucidate their possible role in diabetic nephropathy.Methods　Fetal kidneys from voluntary induction of labor with water bag were cut into pieces;Human mesangial cells were cultivated with the method of renal cortical tissue combined eugenic selection；ELISA was used to measure the expression of TGF-β1.Results　Compared to the normal group, the expression of TGF-β1 in high glucose group were significantly high at 24 h, 48 h, 72 h(P<0.05 or P<0.01).Conclusion　High glucose can increase the expression of TGF-β1 in mesangial cells, which may contribute to the inhibition of ECM degradation in glomerulus and the possibility of diabetic nephropathy.]]> 2018/10/8 8:28:53 YIN Yan-zhi, ZHANG Li-mei, MU Shou-han, et al. 528true ［Abstract］　Objective　To investigate the developmental potential of surplus embryos after embryo transfer or freezing at day 3. Methods　The surplus embryos were extended culture to blastocyst to observe the blastocyst development rate and blastocyst quality, and also the relationship between blastocyst formation and the pregnancy result was analyzed. Results　In 115 IVF/ICSI-ET cycles, a total of 603 surplus embryos were extended culture to blastocyst, formed 222 blastulas(36.82%) among which 49(8.13%) were high-quality blastulas; 53 frozen blastocysts (8.79%) were obtained from 36 cycles(31.30%); 4 of 12 FET cycles achieved clinical pregnancy by transferring the frozen blastocysts formed of surplus embryos. ≥6 blastomeres embryos, 2PN embryos had a significant higher blastocyst development rate than other groups (P<0.05); the blastocyst group had a significant higher clinical pregnancy rate than the group without blastocyst development(P<0.05). Conclusion　It had a limited value of morphological assessment at day 3 to predict the embryo developmental potential; It is a feasible method for increasing the number of available embryos in treatment cycles by blastocyst culture to select the potential embryos; The blastocyst development of surplus embryos could predict the pregnancy result.]]> 2018/10/8 8:28:53 XUE Lin - tao, HUANG Li, HE Bing, et al. 527true ［Abstract］　Objective　To investigate the short term effect and safety of percutaneous balloon mitral valvuloplasty(PBMV) in the treatment of elderly patient with mitral valve stenosis.Methods　Thirty-two elderly patients with mitral stenosis were treated by PBMV. The short term effect of treatment was analysed.Results　The pulmonary artery mean pressure，left atrial mean pressure and mitral valve gradient decreased significantly（P<0.001），the mitral valve area increased significantly（P<0.001）, the cardiac output increased significantly（P<0.05）, the ejection fraction increased significantly（P<0.001）after operation, and there was no serious complication during operation.Conclusion　Using PBMV in the treatment of elderly patient with mitral stenosis can achieve excellent short term effects without serious complications.]]> 2018/10/8 8:28:53 LI Lin, YANG Li-hua, HUANG Chuang 526true ［Abstract］　Objective　To study the relationship between glycosylated hemoglobin and microalbuminuria.The optimal sensitiveity and specificity of various cut-off values of glucosylated hemoglobin for predicting microalbuminuria were examined by receiver operating characteristic (ROC) curve analysis.Methods　Data came from the Qingdao area population-based cross-sectional study, and 3 506 Chinese adults aged 20～70 year and no known diabetes history were enrolled in this study, glycosylated hemoglobin (HbA1c) was measured by HPLC analysis,and UAER was measured by RIA.One ROC curve for the best blood glycosylated hemoglobin cut-offs values for predicting microalbuminuria was made by ROC analysis method.Results　(1)Differences among the urinary quantities of UAER in the five groups of people (divided according to the HbA1c levels )were also significant (P<0.01), with increase of blood glycosylated henoglobin levels, the quantities of UAER significantly increased (P<0.01); (2) There were positive correlations between blood glycosylated hemoglobin levels and the quantities of UAER;(3) The best blood glycosylated hemoglobin cut-offs values for predictting microalbuminuria was 6.3% (sensitivity and specificity are 85.7% and 75.3% respectively).Conclusion　(1) The blood HbA1c levels is closely related to microalbuminuria, and it may predict and evaluate the risk of microalbuminuria.(2) HbA1c≥6.3% is the best HbA1c cut-point for predicting microalbuminuria.]]> 2018/8/27 8:16:11 RAO Xiao-pang,WANG Lin,LU Jun-li 525true ［Abstract］　Objective　To assess the effectiveness and safety of Chinese medical herbs of bushen huoxue in the treatment of infertility women with positive antisperm antibody. Methods　The literature published between 1979～2008 were obtained from databases in Chinese. A comparison between the Chinese medicine and western medicine treatment of randomized controlled trials was perfurmed. Controls were western medicine. Data were evaluated by Meta analysis with Revman 4.2. Results　Seven RCT trials met inclusion criteria. Chinese medicinal herbs were effective compared with Western treatment methods and resulted in higher pregnancy rate ［OR=2.64, 95%CI（1.67,4.16）, P<0.0001］ and antisperm antibody (AsAb) negative rate ［OR=4.42, 95%CI（2.82, 6.93）, P<0.00001］. Conclusion　Chinese medical herbs of bushen huoxue in the treatment of infertility women with positive AsAb may be effective. However, methodological quality of some trials is poor, the validity is uncertain. More strictly designed, randomized, double blind and more cases trials are required.]]> 2018/8/27 8:16:11 LIU Jiu-ying, WANG Lin,LI Lin,et al. 524true ［Abstract］　Objective　To observe the clinical effect of biafine cream in preventing irradiation-induced skin injury of patients with nasopharyngeal carcinoma. Methods　Eighty patients with nasopharyngeal carcinoma undergoing radiotherapy were randomly divided into 2 groups: 40 patients in the treatment group received a biafine cream application following the first radiotherapy, while 40 patients in the control group received no application of the cream, only followed normal procedures for conventional radiotherapy and health education. Results　The irradiation-induced skin reaction occurred in both the treatment group and the control group. A mild radiation reaction (grade-Ⅰ and Ⅱ) occurred in 82.50% of patients (33/40 cases) in the treatment group and 35% of patients (14/40 cases) in the control group. A serve reaction (grade-Ⅲ and Ⅳ) occurred in 17.50% of patients (7/40 cases) in the treatment group and 65% of patients (26/40 cases) in the control group (P<0.01). When the radiation dose was below 40Gy, the skin reaction occurred in 82.5% of patients(33/40) in the control group and in 37.5% of patients(15/40) in the treatment group(P<0.01). Conclusion　Biafine cream can effectively prevent irradiative dermatitis and ensure uneventful radiotherapy.]]> 2018/8/27 8:16:11 CHEN Fang, RUAN Pei-gang, ZOU Yan, et al. 523true ［Abstract］　Objective　To research the effect of shenyankangfu tablet and prednisolone on nephrotic syndrome.Methods　First 51 patients diagnosed as nephrotic syndrome were divided into two groups.The treated group (25 patients)was treated with shenyankangfu tablet and prednisolone,the control group (24 patients) was treated with prednisolone. Before and after treatment,the blood serum albumin,serum creatinine,urine protein quantity per 24 hours and the side effect of medicine were oberserved.Results　The total effective rate of the treated group was 84.0%, that of the control group was 49.9%.There was a significant difference between the two group(P<0.05).Conclusion　Prednisolone combined with shenyankangfu tablet has better effect on nephritic syndrome.It′s side effect is less.]]> 2018/8/27 8:16:11 GONG Rong 522true ［Abstract］　Objective　To study the relationship of the levels serum CA 125 with Child-pugh classification of 1iver cirrhosis and quantity of ascites.Methods　A total of 103 patients were studied,including 36 in Child-pugh A,39 in B,28 in C. There were 55 patients with ascites and 48 without ascites. The levels of serum CA 125 were measured in all patients and in 42 normal persons by ELISA.Results　The levels of serum CA 125 in liver cirrhosis patients were significantly higher than that in controls(P<0.01). The results showed the levels of serum CA 125 in Child-pugh C>in B>in A,increased gradually with aggravating lesion of the liver(P<0.01). The levels of serum CA 125 in liver cirrhosis with ascites group and with small amount ascites group were significantly higher than that without ascites group(P<0.01). The levels of serum CA 125 in liver cirrhosis with middle amount ascites group significantly higher than with small amount ascites group(P<0.01).There were no statistical significant difference in the levels of serum CA 125 between large amount ascites group and middle amount ascires group.Conclusion　The levels of serum CA 125 in 1iver cirrhosis patients have a osculating correlation with lesion of the liver and ascites degree,may serve as a sensitive marker for liver lesion degree and monitoring ascites quantity,and are of value to early diagnosis and estimating prognosis for 1iver cirrhosis patients with ascites.]]> 2018/8/27 8:24:30 HUANG Jun-juan,ZHANG Fa-can,ZHANG Guo 521true ［Abstract］　Objective　To investigate the effect of xue bi jing injection on myocardial damage of patients with septic shock.Methods　Twenty-seven patients with septic shock accompanied with myocardial damage were randomly divided into routine therapy group(control group,n=13),which were given anti-infection,liquid resuscitation,immunity and nutritional support,etc,and xue bi jing group(treated group,n=14),which were supplemented by xue bi jing injection 100ml/day besides the routine therapy.The marker of myocardial damage(troponin-I) was measured before and after the therapy.Results　Concentration of troponin-I was much lower in xue bi jing group than that in control group(P<0.01).Conclusion　xue bi jing injection can effectly improve myocardial damage of the patients with septic shock.]]> 2018/8/27 8:24:30 LIANG Dao-ye,HUANG Jie-min,WANG Rong-hui,et al. 520true ［Abstract］　Objective　To explore the clinical value of hybrid capture (HC-Ⅱ) in detection of high-risk human papilomavirus (HR-HPV) infection in cervical scraping specimens in early diagnosis and treatment of cervical lesions. Methods　Techniques of HC-Ⅱ was used to detect the expression of HR-HPV infection in cervical scraping specimens in 1 169 pations from June 2008 to June 2010. All of them were divided into different groups according to age and degree of cervical lesions. Meanwhile, cervical biopsy under colposcopy for the biology pathology had also been used in some abnormal cases. Results　Positive infection rate of HR-HPV-DNA were 24.89%(291/1169) those in ≤34 years old group and ≥35 years old group were 30.32%（181/597） and 19.23%（110/572）, there was significant difference between the two groups (χ²=19.207； P= 0.000 )； The rate of cervical biopsy was 29.60%, positive infection rate of HR-HPV-DNA in CINⅡ/Ⅲ, CINⅠ and inflammation group were 64.29%(18/28), 37.33%（28/75) and 18.93%（46/243) respectively, which showed significantly higher percentages in CINⅡ/Ⅲ group than those of CINⅠ and inflammation groups （χ²=32.122； P=0.000）. The viral loads (RLU/PC) of HPV in high-degree group was significantly higher than that in inflammation group. Conclusion　HR-HPV infection in young women is more common. HCⅡ-HR-HPV test may reflect the degree of cervical lesions, continuous HR-HPV test would have higher clinical value in early diagnosis and treatment of cervical lesions.]]> 2018/8/27 8:24:30 LIN Zhi-xin, YAN Fang,GUI Qing-hua,et al. 519true ［Abstract］　Objective　To establish the model of acute nectotizing pancreatitis (ANP) -associated lung injury induced by L-arginine in rats.Methods　Forty-eight Spraque-Dawley male rats were randomly divided into tow groups C and A. ANP and APALI were induced by injected intraperitoneally three times with 1.5 mg/g body weight 6% L-Arg in an interval of 1 hour in group A. Group C received saline alone on the same methods. Rats were killed at the 6th,12th and 24th hour after the last time of L-Arg injection. The pathological changes of tissue of pancreatic and lung were respectively analyzed and scored according to Kusser′s and Lei weizhang′s standard. Results　With time going,the pathological injuries of the pancreas and lung in group A were significantly more severely than that in group C(P<0.01). The serum amylase in group A was significantly higher than that in group C,especially at the 24th hour（P<0.01). Pathological injury score in pancreatic showed a correlation with the level of amylase and the lung injury （r^s=0.374,P=0.046；r^s=0.452,P=0.027）.Conclusion　The rat model of acute nectotizing pancreatitis (ANP) -associated lung injury can be induced by intraperitoneal injection of L-arginine(1.5 mg/g,three times)at the concentration of 60g/L at an interval of 1 hour. Lung injury is closely related to pancreatic tissue injury in ANP.]]> 2018/8/27 8:24:30 NIU Gui-jun,TANG Guo-du, ZHONG Wei-yi 518true ［Abstract］　Objective　To investigate the risk factors of macrophage activation syndrome(MAS) in children with kawasaki disease.Methods　A retrospective study was performed on the clinical and laboratory data of 278 KD children from January 2000-May 2008. Then logistic regression was used to identify the risk factors of macrophage activation syndrome in children with kawasaki disease.Results　（1）Of the 278 KD patients, 6 patients (2.1%) were found to have a codiagnosis of MAS and KD; (2)The median age，duration of hospitalizition, time of MAS diagonosis, the days of fever, reaction rate of the treatment of IVIG, hepatosplenomegaly, arthralgia and/or mylagia were higher in MAS patients.but there were not signifcant difference between two groups about redness of palms and soles,bilateral nonexudative conjunctivitis, lip or oral cavity changes, cervical lymphadenopathy, polymorphous exanthema. (3)The level of PLT, WBC, ALb, Fib in MAS patients were lower than that of KD patients. All MAS patients had elevated ALT, elevated AST. elevated LDH, elevated TG, elevated SF, there were signifcant difference between two groups. Conclusion　Multivariate logisitic regression analysis showed that the risk factors of MAS in children with kawasaki disease were >7 age, lasting fever > 10 days, no reaction to the treatment of IVIG, arthralgia, PLT<100×10⁹, ALT>200 U/L, LDH>1 000 U/L, SF>500 μg/L.]]> 2018/8/31 16:02:30 ZHAO Ya-ling, LIANG Kun, XU Jing, et al. 517true ［Abstract］　Objective　To study the tensile strength tests of the new cobalt chromium biology ceramic alloy (CW-CC), BEGO Wirron bord C alloy and Reminum 2000 alloy, for the purpose of future clinical application.Methods　Three kinds of alloys were prepared by five different samples. The tensile strength were measured with a universal testing machine and the analysis of the differences were performed by SEM.Results　There was no statistical significant difference in tensile strength between CW-CC cobalt chromium alloy（785±21)MPa and the German Reminum 2000 alloy (764±15)MPa, but there was a statistical significant difference in tensile strength between CW-CC cobalt chromium alloy（785±21)MPa and German BEGO Wirron bord C alloy (680±12)MPa.Conclusion　The tensile strength of new domestic cobalt chromium bio-ceramic alloy had achieved the performance requirements of ceramic alloy.]]> 2018/8/31 16:02:31 XU Sheng，LI Ning，HUANG Hui-ping 516true ［Abstract］　Objective　To explore the effects and safety of nebulizations inhalation of salbutamol plus budesonide in the treatment of patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods　Eighty patients with AECOPD were randomly divided into four groups: the salbutamol plus budesonide group (combination group), the salbutamol or budesonide group (sole medicine group) and the control group. The basic treatments for the four groups included oxygen,antibiotics，antiasthmatics and apophlegmatisant. The combination group was given nebulizations inhalation of salbutamol plus budesonide, the sole medicine group was only given salbutamol inhalation or budesonide inhalation. All patients underwent pulmonary function test and arterial blood gas analysis before treatment and 1 day, 10 days after therapy. All patients underwent blood glucose test and calcium test before and after treatment.Results　There were no difference among four groups before treatments (P>0.05). One day after therapy, there were significant difference in pulmonary function and arterial blood gas analysis in combination group (P<0.05). Ten days after therapy, there were significant difference in pulmonary function and arterial blood gas analysis among four groups (P<0.05) after treatment. There were no difference between combination group and sole medicine group (P>0.05). There were significant difference between treatment group and control group. There were no difference in blood glucose and calcium in four groups.Conclusion　Salbutamol and budesonide are safe and effective drug in the treatment of AECOPD. Nebulizations inhalation of salbutamol plus budesonide can improve pulmonary function and arterial blood gas of patients with AECOPD in short period.]]> 2018/8/31 16:02:31 JIANG Ke-jia 515true ［Abstract］　Objective　To investigate the clinical manifestation and the characteristics of the treatment of the influenza A (H1N1).Methods　Retrospective analysis was used to analyze the clinical data of 25 influenza A（H1N1）in patients in our hospital from October 29 to November 5 in 2009.Results　These patients were all young man, with continued fever for 4 to 40 hours (mean 20.76±10.86 hours);other common symptoms included cough, asthenia, dizzy and nasal obstruction. Major physical sign was congestion of throat. Laboratory examination showed low counts of WBC and neutrophil granulocyte; high ratio of monocyte, significant high of creatine kinase counts and lower globular protein counts. The body temperature of the patients with fever returned to normal in 2 days after treatment, and met the discharged standard in a week.Conclusion　The toxicity of influenza A (H1N1) is weak. The 25 cases in this study had mild general symptoms, and their disease condition were easy to be controlled through the used symptomatic treatment combined with integrated traditional chinese and western medicine.]]> 2018/8/31 16:02:31 CHEN Ji，YANG Yun-qi，WANG Qing-zhu，et al. 514true ［Abstract］　Objective　To observe the changes of haematology parameter in patients with cancer before and after collection of peripheral blood mononuclear cell with COM. TEC blood cell separator using MNC program.Methods　Using COM. TEC blood cell separator MNC program, the peripheral blood mononuclear cells were collected in 54 patients with cancer.In patients treated by ECTL each processing anticoagulation whole blood was (2055±342) ml, anticoagulants was (225±27) ml, time was (57±13) min.In patients treated by CIK each processing anticoagulation whole blood was (1776±206) ml, anticoagulants (209±27) ml, (49± time for 15) min.Results　After collection WBC, platelet (PLT), hemoglobin (Hb) , hematocrit （Hct）decreased, compared with before collecting, the differences had statistical significance (P<0.05). No serious adverse reactions happened during the collecting process. Conclusion　Although WBC, PLT, Hb, Hct declined after collection, but the changes were respectively in the normal range, and COM. TEC blood cell separator using MNC program can collect enough number of peripheral blood mononuclear cell for cancer immunotherapy. This sampling method is reliable, can satisfy the requirements of clinical treatment.]]> 2018/7/16 16:35:42 CAO Yu-hua，QIU Xiang-ying，FENG Guo-sheng 513true ［Abstract］　Objective　To explore the clinical characteristics of herpes zoster(HZ). Methods　The clinical data of 600 inpatients with HZ was analyzed. Results　There was no significant difference in seasons of onset and sex. Five hundred and thirth-two patients (88.7%) were middle-aged and elderly people, and lumbosacral nerve was affected easily. Elder patients tended to endure more intense pain and longer duration. Conclusion　The incidence of HZ increases in aged population. As for aged population, their condition of HZ is more serious and duration is longer than the young. It should be necessary to pay more attention to them in clinic.]]> 2018/7/16 16:35:42 MEI Ce-fang, ZHU Shao-xuan 512true ［Abstract］　Objective　To explore the clinical treatment method of severe acute viral myocarditis and analyze its efficacy. Methods　The clinical data of 26 cases of severe acute viral myocarditis were retrospectively analyzed including general data, infection situation, clinical manifestations, clinical test results, treatment and prognosis. Results　22 of 26 cases were successfully rescued. The success ratio was 84.6%. 4 cases died, including 2 cases died in the acute stage with cardiogenic shock, the other 2 cases died from acute pulmonary edema.Conclusion　Severe acute viral myocarditis is an acute disease with poor prognosis. More attention should be paid to early diagnosis and positive treatment of this disease.]]> 2018/7/16 16:35:42 WANG Yun 511true ［Abstract］　Objective　To explore the therapeutic effect of lacidipine in the treatment of patients with mild to moderate hypertention. Methods　By the open self-control method, 50 patients with casual blood pressure(CBP) ≥160/95 mmHg affter 2 weeks of stopping antihypertensive drugs, received lacidipine 4～8 mg daily for 4 weeks without any other antihypertensive drugs. The 24 h ambulatory blood pressure monitoring (ABPm) and CBP were obsered. Results　After 4 weeks of treatment CBP reduced, the total effective rate was 88%, the curve of ABPm descended after treatment, the trough-peak ratio of systolic blood pressure was 65.2%, the trough-peak ratio of diastolic blood pressure was 61.1%. Conclusion　Doses of 4～8 mg/d domestic lacidipine have a safe and effective effect in the treatment of patients with mild to moderate hypertention with better tolerance and less adverse reactions. Lacidiple is a safe and effective antihypertensive drug.]]> 2018/7/16 16:35:42 LU Zhi-hong 510true ［Abstract］　Objective　To evaluate the clinical effect of allogeneic hemapoietic stem cell transplantation(Allo-HSCT) with cyclophosphamide (Cy) as conditioning regimen for severe aplastic anaemia(SAA). Methods　One patient with SAA received HLA matched allo-HSCT. Conditioning regimen was Cy 50 mg/kg^-1 · d^-1×4 d. The peripheral blood stem cells (PBSC) + bone marrow stem cells (BMSC) were used as the source of grafts. The infused number of mononuclear cells were 10.41×10⁸/kg and the number of CD34(+) cells were 6.86×10⁶/kg. Cyclosporine A (CsA) and short-course methotrexate(MTX ) and mycophenlate mofetil(MMF) were administered to prevent the graft versus host disease(GVHD). Results　The patient was engrafted. The time for granulocyte count 0.5×10⁹/L and platelet count 20×10⁹/L were 14 days. The blood type was changed into the type donor(B→O) in +96 days. Grade Ⅳ aGVHD developed and was controlled in the patient. Acute suppurative tonsillitis, dental ulcer, acute bronchitis, herpes zoster virus infection, cytomegalovirus viremia and peeumonia occurred in 150 days after allo-HSCT, and these complications were properly disposed. With follow-up of 24 months, the patient survived with disease free. Conclusion　Allo-HSCT with cyclophosphamide as conditioning regimens is a method for curing the patient with SAA.]]> 2018/7/16 16:36:19 LAN Mei，GAO Qing-ping 509true ［Abstract］　Objective　To explore the clinical effect of fresh femoral shaft fracture treated by domestic interlocking intramedullary nail. Methods　In 38 patients with fresh femoral shaft fracture. 34 patients were restorated in small incision, 4 patients received closed restoration and the intramedullary nails were inserted along the line. Results　Thirty-eight patients were followed up for 5～12 months (average 8. 6 months) after operation. The time of fracture healing were 10～15 weeks (average 12. 6 weeks). In 35 patients hip activity return to normal, in 3 patients hip abduction function was restricted slightly (<80%), and in 1 patient with femur shortened about 1 cm. According to the level of pain, range of movement, walking ability, daily life, and using JOA score: excellent effect was found in 21 patients, good in 13 patients, fair in 4 patients, the excellent and good rate was 89. 0%. Conclusion　It can effectively maintain stability of fracture section of fresh femoral shaft fracture treated by domestic interlocking intramedullary nail, with auxiliary restoration in small incision, this method has advantages of small, shorter operation time, less damage to the local blood supply of fracture, lower infection rate, and higher fracture healing rate. It is a good method for treating femoral shaft fracture.]]> 2018/7/16 16:36:19 WEI Ting-qiang 508true ［Abstract］　Objective　To investigate the constitutive characteristics of gynecologic malignant neoplasmas in hospitalized patients. Methods　A retrospective analysis of the clinical date of 424 hospitalized patients with gynecologic malignant neoplasmas were performed. Results　Three leading types of malignant neoplasmas were cervical cancers, endometrial cancers, and ovarian cancers according to the constitutive ratios of the 424 patients with neoplasmas. The age of occurrence of cervical cancers and ovarian cancers were 40～50 years, but the age of occurrence of endometrial cancers were 50～60 years. The ratio of early diagnosis and treatment of cervical cancers, endometrial cancersis weas higher than that of ovarian cancers. The ratio of ovarian cancers of young females was higher than that of senile females. And the ratio of cervical cancers and ovarian cancers of young and senile females were higher than that of all hospitalized patients (P<0. 05). Conclusion　It should be necessary to strengthen the screening program of cervical cancer, and pay more atention to prevention and control of other gynecological reproductive organ tumors at the same time, a improve early diagnosis and treatment of gynecologic malignant neoplasms.]]> 2018/7/16 16:36:19 LIU Ni-ping, CHEN Chang-yi 507true ［Abstract］　Objective　To investigate the infection of helicobacter pylori(Hp) and its relationship to serum lipids in patients with coronary heart disease(CHD).Methods　Serological antibodies of anti-Hp-CagA and anti-Hp were determined in 78 patients with CHD and 30 healthy controls by ELASA assay. The positive rate of Hp and its relationship with the levels of serum lipids were analyzed.Results　Anti-Hp and anti-Hp-CagA antibody positive rates in patients with CHD were obviously higher than those in controls (P<0.01). Serum levels of cholesterol, triglyceride and low density lipoprotein including apolipoprotein A1 and B in anti-Hp positive patients with CHD were higher but high density lipoprotein was lower than those in anti-Hp nagative patients with CHD (P<0.05).Conclusion　Hp infection may induce the occurrence of CHD by modifying the serum lipid profile in a way that increases the risk of atherosclerosis.]]> 2018/7/16 16:37:43 ZHANG Ai-guo, LIU Qing-miao, MENG Li-ying, et al. 506true ［Abstract］　Objective　To study the cause and preventive measures of uterine rupture during the pregnancy.Methods　The clinical data of 47 cases of uterine rupture in late pregnancy in Maradi hospital (Niger, west african area) from November 2008 to November 2010 were retrospectively analyzed.Results　Forty-three cases were cured completely,another 4 cases were dead.The mortality rate was 8.5%. The fetuses in 5 cases of incomplete uterine rupture were all alive. In 42 cases of complete uterine rupture,the fetuses in 3 cases without placental separation were alive.The others (39 fetuses) all were dead. The mortality rate of fetus was 83.0%.There were 4 cases of vesicovaginal fistulae between 4 and 30 days after cesarean section.Conclusion　It would lower the fetal or maternal mortality rate if the diagnosis of uterine rupture could be gotten earlier during the pregnancy period,for surgical management being performed in time.It is urgent for the physicians all over the world to lower the caesarean section rate for decreasing the risk of scar rupture in subsequent pregnancies.At the same time, skilled management of difficult vaginal delivery,as well as rational use of oxytocin,could decrease the incidence of uterine rupture.]]> 2018/7/16 16:37:43 WU Yue-lian, HUANG Lin 505true ［Abstract］　Objective　To investigate the effect of sequential mechanical ventilation in severe pneumonia patients with severe respiratory failure and the feasibility of the pulmonary-infection-control window (PIC) combined with spontaneous breathing trial(SBT).Methods　Some severe pneumonia patients with severe respiratory failure were analyzed retrospectively. These patients were divided into treated group (35 cases) and control group (26 cases). The time of invasive and mechanical ventilation, days in ICU and condition of reintubation and nosocomial death were studied.Results　Compared with the control group, the time of invasive and mechanical ventilation, the condition of reintubation and days in ICU of treated group was decreased significantly. There was no significant difference in the total mortality between the two groups.Conclusion　(1)The sequential mechanical ventilation was better than the conventional mechanical ventilation, because it can decrease the time of invasive and mechanical ventilation, the condition of reintubation and days in ICU; (2)There is no enough evidence that the sequential mechanical ventilation can decrease the total mortality; (3) The sequential mechanical ventilation in severe pneumonia patients with severe respiratory failure and the application of the PIC combined with SBT was a feasible approach.]]> 2018/7/16 16:37:43 ZHU Yun-feng,TANG Zhong-ping,LIN Feng,et al. 504true ［Abstract］　Objective　To investigate the exploration value of laparoscopy in obscure small intestinal bleeding.Methods　The clinic data of 14 patients with obscure small intestinal bleeding undergoing laparoscopic exploration in our hospital from September 2003 to February 2009 were analyzed.Results　All the patients were cured successfully. The mean operation time was (70.3± 32.6) min, the mean intraoperative blood loss was (16.1±12.4)ml.The mean hospital days after operation was (7.9±3.1)d. All the patients were followed up from 3 to 30 months. No complications or rehemorrhage was found.Conclusion　The laparoscopic exploration has the advantages of exact positioning, less bleeding, less operation time, less complication and quicker recovery in diagnosis and treatment of patients with acute small intestinal bleeding and is worthy of clinical popularization.]]> 2018/7/16 16:37:43 ZHANG Gui-nian, HUANG Shun-rong, QIN Qian-zi, et al. 503true ［Abstract］　Objective　To observe the endogenous hydrogen sulfide(H₂S) on viral replication of myocardium in coxsackievirus B₃(CVB₃) induced viral myocarditis(VMC) of mice, and to explore the endogenous H₂S on pathogenesis of VMC. Methods　Male Balb / c mice were inoculated intraperitoneally with CVB₃ to reconstrute an animal model of myocarditis. Seventy-five male Balb / c mice were randomly divided into five groups (n=15): normal control group, VMC group, D, L-prepargylycine ［PAG, an irreversible inhibitor of cystathionine-γ-lyase (CSE) ］ low-dose, middle-dose and high-dose intervention groups, PAG was administered by subcutaneous injection (sc). The mice were inoculated intraperitoneally with CVB₃ while sc PAG(the dosage of PAG in three intervention groups were 20.0, 40.0, 80.0 mg·kg^-1, respectivelly) each day one time for six times. All mice were sacrificed at seven days after inoculated intraperitoneally with CVB₃. The pathological changes of myocardial tissues were observed with light microscope. The content of H₂S was determined by spectrophotometry in myocardial tissue. The activity of CSE and content of cardiac troponinⅠ(cTnⅠ) were determined by enzyme-linked immunosorbnent assay method in myocardial tissue and serum, respectively. The expression of CVB₃mRNA was detected by reverse transcription-ploymerase chaine reaction in myocardial tissue. Results　VMC group compared with normal control group: The activity of CSE and content of H₂S in myocardial tissues were significantly lower than those in normal control group（P﹤0.01), the pathological scores and expressive level of CVB₃mRNA in myocardial tissues, the content of cTnⅠin serum were significantly higher than those in normal control group（P﹤0.01). PAG three intervention groups compared with VMC group: The activity of CSE and content of H₂S in myocardial tissues were significantly lower than those in VMC group（P﹤0.01), the pathological scores and expressive level of CVB₃mRNA in myocardial tissues, the content of cTnⅠin serum were significantly higher than those in VMC group（P﹤0.01). Conclusion　The CVB₃ replication was inhibited by endogenous H₂S in myocardium.]]> 2018/7/31 15:05:07 WANG Min, YANG Guan-ming 502true ［Abstract］　Objective　To analyze the clinical features of biliary origin pyogenic liver abscesses(PLA) and cryptogenic origin PLA, and provide the evidence for diagnosis and treatment in cryptogenic origin PLA.Methods　Clinical data of 61 cases with pyogenic liver abscesses from July 2001 to June 2010 were reviewed retrospectively.According to aetiology, all cases were divided into the biliary group (n=25) and cryptogenic group (n=36).Results　Cryptogenic group had a higher frequency of underlying diabetes,and biliary group had a higher frequency of underlying bile duct stones, there was significant difference between two groups (P<0.05)； Fever/chill,white blood cell increased,CRP increased and single abscess were more often presented in the cryptogenic group than in the biliary group, abdominal pain,jaundice,AKP increased and multiple abscesses were more often presented in the biliary group than in the cryptogenic group,there were significant difference (P<0.05)；There was a higher fequency of positive blood cultures in the cryptogenic group than in the biliary group,K. pneumoniae were more frequently isolated in the cryptogenic group,E.coli were more frequently isolated in the biliary group, there were significant difference (P<0.05).Conclusion　Compared to those patients with PLA of biliary origin, patients with PLA of cryptogenic origin had a higher frequency of underlying diabetes, fever/chill,white blood cell increased,CRP increased and single abscess were more often presented, there was a higher fequency of positive blood cultures, and K. pneumoniae were more frequently isolated in the cryptogenic group.]]> 2018/7/31 15:05:07 LONG Di,BI Yong-hao,HUANG Heng-yi, et al. 501true ［Abstract］　Objective　To explore the application and significance of geographic information system (GIS) technology in case analysis. Methods　2009 cases of cesarean section in our hospital were counted, GIS to was applied epidemiological spatial statistic and spatial analysis, and drawing a visual geographic distribution map. Results　The global Moran′s I value of Guangxi is 0.02, Z inspection results is 2.54, P value is less than 0.05, results show that, the spatial distribution of puerperants who choose cesarean section in our hospital in 2009 is gathering distribution, especially in Nanning, the distribution is even more focused(Moran′s I value is -0.53, Z value is -1.32, P value is greater than 0.05). Conclusion　GIS technology can be used to do some certain diseases epidemiology investigation and case statistical analysis, and also can draw the results′ visual intuitive distribution map, provide evidence and data support for prevention and control work.]]> 2018/7/31 15:05:07 CHU Min, ZHOU Hong-xia 500true ［Abstract］　Objective　To provide a scientific basis for prediction of progressive ischemic stroke through contrastive study on changes of high sensitive C-reaction protein and D-dimer of patients with progressive and patients with non- progressive ischemic stroke.Methods　Serum high sensitive C-reaction protein and D-dimer at different corresponding time points in above-mentioned two groups of patients and controlled healthy people were detected by immunonephelometric assay and enzyme-linked immunosorbentassay(ELISA),and the results were compared.The resulting neurological deficit of patients with acute ischemic stroke were judged according to the Scandinavian Stroke Scale (SSS).Results　The order of D-dimer level in progressive ischemic stroke group was that 7d after the onset >3 d after the onset >within 24 h after the onset >14 d after the onset. D-dimer level in progressive ischemic stroke group was significantly higher than non- progressive ischemic stroke group during 1 w after the onset（P<0.01）. The order of high sensitive C-reaction protein level in progressive ischemic stroke group was that 3 d after the onset >7 d after the onset >within 24 h after the onset >14 d after the onset. High sensitive C-reaction protein level in progressive ischemic stroke group was significantly higher than non- progressive ischemic stroke group on 3 d and 7 d after the onset （P<0.01）. The return of the resulting neurological deficit of progressive ischemic stroke was worse than non- progressive ischemic stroke group at the end of 3 w（P<0.01）.Conclusion　Elevated high sensitive C-reaction protein and D-dimer levels are closely related to the occurrence of progressive ischemic stroke and could be a prediction index of progressive ischemic stroke.]]> 2018/8/1 8:23:53 LI Li 499true ［Abstract］　Objective　To observe the influence of endothelial progenitor cells (EPCs) on the osteogenic effects of autologous bone marrow stromal cells (BMSCs) of rats in vitro co-culture of EPCs and BMSCs.Methods　BMSCs and EPCs were obtained from rat bone marrow and peripheral blood by density gradient centrifugation.The cultured cells were divided into four groups：group A (BMSCs)，group B (EPCs osteogenic induction)，group C (BMSCs osteogenic induction) and group D(co-culture of induced BMSCs and EPCs).The EPCs were identified with immunocytochemistry staining. The cell proliferation and alkaline phosphatase (ALP) activity were observed to determine the effects of the osteogenic potential and cellular compatibility in each group.Results　The cells were able to line up in the cord-like structure and showed CD31、vWF、positive in group B. There was good compatibility when EPCs and induced BMSCs were co-cultured. The activity of ALP in the group C and D was higher than the other two groups.Conclusion　In direct co-culture system in vitro, the cellular compatibility is perfect. EPCs can improve ALP activity of induced osteoblasts.]]> 2018/8/1 8:23:53 WEI Hui-ping,PANG Fang-he 498true ［Abstract］　Objective　To investigate the prevalence rate of depression and understand the influencing factors of depression in the HIV-infected outpatients, determine the risk and protective factors of depression, and provide valuable information for effective intervention measures.Methods　Four hundred AIDS out-patients in the infectious disease special hospital were surveyed by Zung designed “Depression Scale” (SDS) to determine the prevalence rate of depression and the epidemiological influencing factors. Outcome was analyzed by SPSS16.0.Results　The prevalence rate of depression in out-patients was 46.25%. However fourteen factors was used to multivariate Logistic regression analysis,only eight factors eventually enter the model.These were age, education level, morbid state, social support, drug history,shame, negative life events, and adverse drug reaction,and the adjusted OR values and ORCI respectively is 4.133 (1.774～9.627), 2.515 (1.185～5.337), 5.038 (1.941～13.076), 0.510 (0.265～0.976), 2.913 (1.194～7.110), 2.099 (1.080～4.080), 29.753 (17.965～56.155), 2.816 (1.349～6.054).Conclusion　Prevalence of depression in out-patients is significantly higher than the national norm. The risk factors for depression according to the relevance (OR) in the order is negative life event, AIDS, ≥history of 50 years, drug abuse, drug side effects, education level, a sense of shame.The protective factors of depression is social support.]]> 2018/8/1 8:23:53 DONG Wen-yi,GENG Wen-kui，HUANG Jin-ping,et al. 497true ［Abstract］　Objective　To investigate the clinical significance of analysis of serum Lipoprotein(a)［Lp(a)］ level in diagnosis of early diabetic nephropathy(DN). Methods　One hundred and eighteen patients with diabetes mellitus were divided into 3 groups according to 24-hour urinary albumin excretion rate(UAER): group A(patients without DN), 41, UAER<30 mg/24 h; group B(early DN), 39, 30 mg/24 h≤UAER<300 mg/24 h; group C(clinical DN), 38, UAER≥300 mg/24 h. Forty healthy volunteers were as control group(group D). The UAER and serum Lp(a) were tested in all patients. The results were analyzed with ANOVA and Linear correlation. Results　The serum Lp(a) level of group A, B, C was higher than that of group D（group A vs. D, P<0.05，group B and C vs. D, P<0.01）, and was increasing with the progression of DN (group B vs. A, P<0.01，group C vs. B, P<0.05).The level of Lp(a) of group A and B were positive linear correlation with UAER(group A, r=0.356, P< 0.05；group B, r=0.438, P<0.01).Conclusion　Serum Lp(a) level may be related with the lesion of DN, the analysis of Lp(a) would be one of the adjunctive methods in the diagnosis of the early stage of this disease.]]> 2018/8/1 8:23:53 ZHANG Chang-ming, LONG Yan, SU Ke, et al. 496true ［Abstract］　Objective　To study the correlation between the drift rate of serum Th1/Th2 and thyroid ¹³¹I conversion rate in patients with Graves disease. Methods　Sixty patients with Graves disease(GD group) and thirty healthy people(control group) were selected and compared. In this study, IL-2 represented cytokines of Th1, IL-6 represented cytokines of Th2. Results　IL-6 in GD group was obviously higher than that in the control group（P<0.01）； IL- 2 in GD group was obviously lower than that in the control group（P<0.01）； There was no correlation between IL-2、 IL-6、 IL-2/IL-6 and ¹³¹I conversion rate. Conclusion　The imbalance of Th1/Th2 cytokines in patients with GD was in favour of Th2.There was no correlation between the drift rate of Th1/Th2 cytokines and thyroid ¹³¹I conversion rate.]]> 2018/8/1 8:23:53 LI Hong-kun, QIN Wei-wu, XIE Yong-Shuang, et al. 495true ［Abstract］　Objective　To investigate the effect of different levels of serum FT3 concentration on the turnover rate of radioiodine.Methods　The serum concentration of FT3 and the uptake of radioiodine at 3 h and 24 h in 438 Graves hyperthyroidism patients were mesured.All the patients were divided into three groups by different FT3 levels and classified into four degrees by different levels of the turnover rate of radioiodine.Results　The turnover rate of radioiodine showed statistically significant between the three groups（P<0.05）.Conclusion　Different levels of serum FT3 concentration have different effect on the turnover rate of radioiodine,the levels of serum FT3 concentration can be used for estimating the level of the turnover rate of radioiodine.]]> 2018/8/1 9:43:06 LI Yan,QIN Wei-wu,LI Xiu-qiong,et al. 494true ［Abstract］　Objective　To study the influence of G6PD deficiency on MCV and MCH of the thalassemia gene carriers.Methods　The enzyme assay and blood cell analysis were performed in pregnant women and their husbands who were confirmed as thalassemia gene carriers in prenatal screening in our hospital from June 2006 to December 2008. The carriers were divided into two groups: the G6PD deficiency group and normal G6PD group and then their MCV and MCH were compared.Results　MCV and MCH in α-thalassemia-1 gene combined with G6PD deficiency group were obviously higher than those in α-thalassemia-1 gene combined with normal G6PD group（P<0.05）. MCV in light β-thalassemia gene combined with G6PD deficiency group was obviously higher than that of light β-thalassemia gene combined with normal G6PD group（P<0.05）. MCH in light β-thalassemia gene combined with G6PD deficiency group was higher than that of light β-thalassemia gene combined with normal G6PD group. However, the difference did not have statistias significance.Conclusion　G6PD deficiency can influence the sensibility of MCV and MCH in thalassemia screening, leading to the missed diagnosis. Therefore, blood cell analysis, hemoglobin electrophoresis, red cell osmotic fragility test, and detection of G6PD activity are recommended to jointly screen thalassemia, aiming to increase detection rate of thalassemia gene carriers and reduce birth defects.]]> 2018/8/1 9:43:06 QIN Ting,ZHAO Lin,XU Li-li 493true ［Abstract］　Objective　To study the therapeutic effect of penequinine hydrochloride(PH) on the shock.Methods　According to the date of visiting hospital, 67 patients with shock were ramdomly divided into two groups: PH group and 654-2 group.In addition to routine therapy, PH group was given the PH while the 654-2 group was given anisodamine.The heart rate,blood pressure,central venous pressure,gurgling sound,urine output,SPaO₂,duration of peripheral warming,serun lactic acid were measured and compared at 1,6,12 h after medication.Results　All the above mentioned indexes in the PH group were significantly better than those in the 654-2 group. Conclusion　The antishock effect of PH is better than that of anisodamine.]]> 2018/8/1 9:43:06 LIANG Hui-jun,ZENG Xiao-long 492true ［Abstract］　Objective　To investigate the clinical applications of broncho-alveolar lavage in the patients with acute respiratory failure in ICU. Methods　The clinical data of 35 patients with respiratory failure， together with difficulty to cough up phlegm，atelectasis or pulmonary infection were chosen. These patients were treated with suction，broncho-alveolar lavage and local injection under bronchofiberscope and monitored the heart rate, blood pressure, respiration, oxygen saturation of blood and blood gas analysis,when it is ineffective in the treatment of oxygen therapy, anti-infection, spasmolysis, antiasthmatic, expectorant, or mechanical ventilation. Results　In all treated patients the clinical symptoms were improved, the PaO₂ and SaO₂ were markedly increased compared with those before treatment (P<0.05). Conclusion　The treatment with suction, broncho-alveolar lavage and local injection under bronchofiberscope is effective in the treatment of patients with acute respiratory failure and can rapidly relieve atelectasis and dyspnea caused by airway obstruction and is helpful in airway management and infection control， and it can significantly shorten patients′stay time in the ICU, reduce hospitalization time and cost, and can be widely clinically applied.]]> 2018/8/1 9:43:06 ZHOU Hong-wei,ZENG Hong,LU Jian-fang,et al. 491true ［Abstract］　Objective　To study the variation and significance of ankle-brachial index(ABI) in patients with unstable angina pectoris(UAP).Methods　There were detected for serum creatinine, blood uric acid, blood-lipid, serum glucose, serum levels of hs-CRP and ABI in 105 UAP patients with PCI (UAP group) and 96 coronary arteriongraphy normal ones(control group),and the difference in above indexes between the two groups were compaired.Results　The serum levels of hs-CRP in UAP patients were higher than the control group（t=22.287，P<0.001）,but the ABI（t=5.461，P<0.001）lower.Conclusion　Early monitoring of ABI and hs-CRP could be useful in prevention and treatment in UAP,but ABI was more suitable for clinical application.]]> 2018/8/17 8:09:35 HUANG Zong-yan, LIN Ying-zhong, LIU Ling,et al. 490true ［Abstract］　Objective　To compare the effects between the anatomical plate and dynamic hip screw(DHS) in the treatment of intertrochanteric fracture of the femur.Methods　The two types of internal fixation for the treatment of intertrochanteric fracture of femur were applied in 56 patients.Of them 27 patients were treated by anatomical plate (A group), 29 patients were treated by DHS (B group).the statistics of intraoperative bleeding volume, operative time, postoperative drainage volume, postoperative complications and hip joint function and so on were performed between two groups.Results　There was no significant difference in the clinical efficacy between anatomical plate and DHS in the treatment of intertrochanteric fracture of the femur(P>0.05), but the A group is superior to B group in the intraoperative bleeding volume, operative time and postoperative drainage volume (P<0.05).Conclusion　Anatomical plate in the treatment of intertrochanteric fracture of the femur have advantages such as simple operation, less damage, reliable fixation and so on,and it is a better treatment method of intertrochanteric fracture of the femur.]]> 2018/8/17 8:09:35 WANG Wen-quan，LI Dong-hai，LI Tong-lin，et al. 489true ［Abstract］　Objective　To observe the short-term results of patients who underwent valve replacement operation combined with bipolar radiofrequency ablation (RFA) modified Cox-Maze procedure.Methods　From October 2009 to March 2010, 14 consecutive patients underwent valve replace operation combined with a modified Cox-Maze procedure with bipolar radiofrequency ablation for AF; the short-term results were analyzed retrospectively.Results　The mean preoperative AF duration was （28.6±13.5）months.The mean perfusion and cross-clamp times were （88.7±10.4）min and （41.7±8.2） min, respectively.No preoperative death.No patient required implantation of a permanent pacemaker.During discharge, all patients were in sinus rhythm.Patients were followed up for a mean duration of （4.7±1.2）months (range: 3～6 months). During follow-up period, 13 patients (93.4%) remained in sinus rhythm,late death occurred in one patient.Conclusion　Valve replace operation combined with bipolar radiofrequency ablation (RFA) modified cox maze procedure is a safe and efficient method to patients with valvular disease of the heart and atrial fibrillation. The use of bipolar RF energy significantly decreased cross-clamp times and simplified the procedure compared to the traditional Cox-Maze procedure, potentially increasing utilization of the procedure among cardiac surgeons.]]> 2018/8/17 8:09:35 LIANG Sheng-jing,LIN Hui,LI Xiang-wei,et al. 488true ［Abstract］　Objective　To investigate the related factors influencing corneal endothelial cells and the importance of measuring corneal endothelial cells before intraocular surgery.Methods　Retrospective study on 100 inpatients treated in the People′s Hospital of Guangxi Zhuang Autonomous Region were performed, the counts of corneal endothelial cells were measured before surgery, and SPSS17.0 statistical software was used for correlation analysis and t test.Results　The associated degree of age, sex, nation and ocular trauma with the counts of corneal endothelial cell was low, the associated degree of intraocular surgery with the counts of corneal endothelial cell was normal. The counts of corneal endothelial cells in patients′ eyes had intraocular surgrey was higher than that in contralateral healthy eyes (P<0.05). There were no significant statistic differences in counts of corneal endothelial cell between patients′ trauma eye and contralateral healthy eyes (P>0.05).Conclusion　It′s important to measure corneal endothelial cells before intraocular surgery and it could help to reduce the corneal endothelial decompensation.]]> 2018/8/17 8:09:35 LI Jing-bo,LI Min 487true ［Abstract］　Objective　To study the recurring factors and treatment of recurrent pituitary tumors.Methods　Thirty-eight cases of recurrent pituitary tumor were reviewed, including their clinic presentations, imaging data, therapy methods, and results. Of 38 cases, 31 cases received second surgical removal, 4 cases received γ-knife, 2 cases PRL-adenomas received medicine, and one PRL-adenoma received no treatment. Of 14 cases received first trans- sphenoid operations, 11 cases received second trans-sphenoid operations and 3 cases received second trans-pterion operations. Of 11 cases received first sub-frontal operations, 7 cases received second trans-sphenoid operations and 4 cases received second sub-frontal operations.Results　Of 31 cases received second surgical removal, 21 cases tumors received total recession, 7 cases subtotal recession, and 3 cases major recession. Of 2 cases PRL-adenomas received medicine, one got normal PRL level and tumor diminution. Of 4 cases received γ-knife, 3 cases tumors diminuted and one got no change.Conclusion　Surgical removal is most effective method for recurrent pituitary tumor. Medicine is an aid therapy, which got tumor diminution and normal PRL level. Radiotherapy made tumor necrosis, diminution, and hormone level decreasing. For those could not get total recession by second surgical removal, tumor tissue around optic nerve and chiasm should be resected as far as possible in order to radiotherapy.]]> 2018/8/17 8:10:44 YE Jin，XU Ke-bei，ZHONG Shu，et al. 486true ［Abstract］　Objective　To observe the comprehensive rehabilitation therapy in the treatment of patients with multi-infarct dementia(MID).Methods　Sixty patients with MID were randomly divided into three groups,there were 20 patients in each group.The routine treatment gtoup received routine therapy;the xingnaojing group received xingnaojing injection therapy on the basis of routine therap;the comprehensive group received acupuncture therapy on the basis of above therapy.The therapentic effects among 3 groups were compared.Results　The MMSE score and ADL score in 3 groups increased after the treatment. The scores of the comprehensive group significantly increased than that of the routine treatment group(P<0.05).Conclusion　Comprehensive rehabilitation therapy has a good therapcutic effect on the cognitive function of patients with multi-infarct dementia.]]> 2018/8/17 8:10:44 WU Zan-hua 485true ［Abstract］　Objective　To assess the efficacy and safety of cervus and cucumis polypeptide injection in treating fracture of extremities.Methods　MEDLINE(1950 to 2010),EMBASE(1974 to 2010)，the Cochrane Library (Issue 4,2010) CBM（1978 to March 2010）,Wanfang database(1982 to March 2010),and CNKI(1979 to 2010) were searched.Some related journals were searched by manul operation as well.The search had no language limit and the deadline was March 2010.The subjects were the patients with fraction of extremities.The quality of included randomized controlled trials was evaluated and meta-analysis was conducted by the Cochrane collaboration′s software Revman 4.2.2.Results　Eight studies involving 1437 patients (792Males,645Females) were included.It was revealed that the cervus and cucumis polypeptide injection had a positive effect in treating fracture of extremities(OR=3.29,95%CI 1.25 to 8.67,P=0.02<0.05). However,there was rare studies in demonstrating the certain type of fracture and the sample was rare, so the clinical effect of certain type of fracture cannot be analyzed. The reports on the side effect were found in 3 studies;The side effects were not found in other 5 studies, and no drop-out was recorded.Conclusion　The preliminary studies has shown the positive clinical effect of cervus and cucumis polypeptide injection in treating fracture of extremities,the drug has low side-effect rate and high safety in using,but further study is needed.]]> 2018/8/17 8:12:31 MEI Jie, PENG Hao, YIN Dong 484true ［Abstract］　Objective　To analyze the situation and tendency of mutual aid blood donation(MABD) in Nanning.Methods　According to registration form of MABD and MABD′s aim patients were divided to four parts:leukemia,tumor,operation,others. The number of MABD′s aim patients and MABD participants,the used and donated volume of blood were calculated, and the situation of MABD in Nanning was analyzed.Results　The number of MABD participants increased gradually during 2009-08 to 2010-05.One thousand, one hundred and eighty-nine patients got 814 unit platelet,3 140 U erythrocytes and 1 773 U blood plasma provided by 3 047 people. Conclusion　MABD is a kind of blood donation ensuring clinical blood provision. Although it makes a perfect beginning in Nanning, we shall prevent it′s malpractice also.]]> 2018/8/17 8:12:31 LI Bin,LIANG Ri-mei,ZENG Shao-hong,et al. 483true ［Abstract］　Objective　To establish a general anaesthesia model without bronchial cannula for Guangxi bama miniature pig.Methods　Eight male Guangxi bama miniature pigs were chosen. Ketamine hydrochloride injection in a dose of 0.1 g and diazepam injection in a dose of 10 mg were used to anaesthetize Guangxi bama miniature pigs through intramuscular injection behind the pigs′ ears.Then Guangxi bama miniature pigs were anaesthetized with ketamine hydrochloride injection and diazepam injection through intravenous anaesthesia discontinuously.While the operations were done on urinary system,the depth of anaesthesia was adjusted according animal′s heart rate,eyelash reflex and pain response.Results　Eight Guangxi bama miniature pigs recovered well and the effects of anaesthesia were satisfactory. Conclusion　It was a safe,effective,simple and easy method to anaesthetize Guangxi bama miniature pig with diazepam injection and ketamine hydrochloride injection discontinuously.]]> 2018/8/17 8:12:31 DENG Da-zhi，LIU Gang 482true ［Abstract］　Objective　To investigate the effects of atorvastatin calcium tablets combined with tongxinluo capsule on intima-media thickness (IMT) of the common carotid artery and the levels of plasm inflammation markers in patients with hyperlipidemia and carotid artery atherosclerosis.Methods　Seventy patients with hyperlipidemia and carotid artery atherosclerosis were randomly divided into the treatment group and control group. Both were given general treatment. The treatment group were given atorvastatin calcium tablets 20 mg, once a day, combined with tongxinluo capsule, 4 tablets, three times a day. Meanwhile, the control group were only given atorvastatin calcium tablets 20 mg, once a day.Both were treated for 12 weeks. The levels of TC, TG, LDL-C, HDL-C, hs-CRP, TNF-α were determined and color doppler echo-cardiography was used to measure IMT of the common carotid artery before the entry into the trial and after 12 weeks of the trial, respectively.Results　After 12 weeks, the concentration level of TC,TG,LDL-C,hs-CRP,TNF-α,IMT were all decreased significantly (P<0.05), meanwhile, HDL-C was increased significantly (P<0.05) in both groups. But in treatment group, the concentration level of TC,TG,LDL-C, hs-CRP, TNF-α, IMT were significantly lower and HDL-C was higher than those in control group (P<0.05).Conclusion　Atorvastatin calcium tablets combined with tongxinluo capsule can effectly regulate blood fat, reduce inflammation, resist arteriosclerosis and reverse or delay the process of the carotid artery atherosclerosis.]]> 2018/6/28 8:50:28 WANG Hua，HUANG Ling，CHEN Ping, et al. 481true ［Abstract］　Objective　To evaluate the effectiveness, feasibility and safety of laparoscopic surgery in patients with ectopic pregnancy complicated with hemorrhagic shock. Methods　One hundred and nineteen patients with ectopic pregnancy complicated with hemorrhagic shock（67 patients of laparoscopy group and 52 patients of laparotomy group） treated in our hospital were analyzed retrospectively. The hospital time, duration of operation, time of entering the abdominal cavity, intraoperative blood loosing, postoperative farting time and complications between the two groups were compared. Results　The mean operation duration of laparoscopy group was（42.0±7.0）minutes, laparotomy group was （45.0±12.0）minutes, no significant difference was found between two groups（P>0.05）. Intraoperative blood loosing of laparoscopy group was（34.0±17.0）ml, laparotomy group was（42.0±7.0）ml, there was significant difference between two groups as well（P<0.01）. Time of entering the abdominal cavity in laparoscopy group was （1.5±1.0）minutes, shorter than （6.5±1.0）minutes in laparotomy group（P<0.01）. Postoperative farting time in laparoscopy group was （13.5±4.5）hours, shorter than （37.5±12.5）hours in laparotomy group. The hospital time in laparoscopy group was（4.22±1.20）days, shorter than （6.74±1.67）days in laparotomy group（P<0.01）. There were no intraoperative and postoperative complications and death in two groups. Conclusion　With the aid of effective anti-shock therapy，perfect monitoring and nursing of physiological parameters and anesthesia management, combined with skillful laparoscopic operation technique, laparoscopic treatment in patients with ectopic pregnancy complicated with hemorrhagic shock can be safe，effective and feasible.]]> 2018/6/28 8:50:28 LEI Dong-lan, LEI Yan-liu, NING Fen-rong 480true ［Abstract］　Objective　To comprehend the characteristics and general rules of adverse drug reaction(ADR) in our hospital, in order to provide suggestion for rational use of medicines in clinical practice.Methods　A retrospective analysis of 1393 ADR reports in our hospital from Jan.2008 to Jun.2011 were analyzed.Results　Of 1393 ADR reports, with total 1 666 cases of drugs induced ADR 211 classes of drugs were involved, and drugs combination more than one class approximated 5%. The greatest proportion of ADR was caused by antimicrobial agents (860 cases, 51.62%), followed by agents for nutritional support and energy metabolism (150 cases, 9%); Main route of administration was intravenous injection (1 211 reports, 86.93%); The doseage-form of medicine was injection primarily (1 518 cases, 91.12%); Organ or system involved in ADR mainly were skin and its appendants (760 reports，54.56%)，followed by systemic and digestive system. In outcome of ADR，1389 patients were cured or improved, 2 patients suffered from sequelae, 2 patients died.Conclusion　The occurrence of ADR is related to many factors. ADR monitoring and report should be strengthened in the clinic, in order to promote rational and safe use of medicines in the clinic.]]> 2018/6/28 8:50:28 YANG Tian-yan, LI Mei, WANG Jin, et al. 479true ［摘要］　目的　明确阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea,OSA）患者戴入治疗有效的口腔矫治器后髁状突的位置变化。方法　选取21例使用口腔矫治器成功治疗的OSA患者参加研究，采用经颅咽方向投照双侧颞下颌关节的方法摄取闭口位、最大开口位及戴有效的口腔矫治器后双侧颞下颌关节的数字化X线片。测量髁状突的位置并作三个不同下颌位置的比较，对髁状突位置的变化及戴用口腔矫治器后的疗效变化作相关分析。结果　三个髁状突位置明显不同。患者戴入治疗有效的口腔矫治器后髁状突的最上点座标为X（-1.21±1.98）mm，Y（-0.68±1.08）mm。髁状突位置的变化与口腔矫治器疗效的变化无明显相关性，x值的相关系数为r=0.057，y值的相关系数为r=0.024。结论　戴入有效的口腔矫治器后髁状突的最上点为靠近于颞下颌关节的结节点。]]> 2018/6/28 8:51:28 黄敏方，周　嫣，陈世稳，方志欣，钟　易，KO Ching-chang 478true ［Abstract］　Objective　To explore the clinical effect of mesh-plug tension-free herniorrhaphy for incarcerated inguinal hernia.Methods　The clinical data of 14 patients with incarcerated inguinal hernia treated with ultrapro hermia system (UHS) for mesh-plug tension-free herniorrhaphy were retrospectively analyzed.Results　All patients were operated successfully. The follow-up period ranged from 8 months to 3 years. No recurrence was observed.Conclusion　Application of mesh-plug tension-free herniorrhaphy for incarcerated inguinal hernia is viable in case of indications strictly well being controlled.]]> 2018/6/28 8:51:28 ZHAI Dong-sheng 477true ［Abstract］　Objective　To explore the application of somatostatin in treatment of enterocolitis after surgical treatment for Hirschsprung′s disease. Methods　Patients with enterocolitis after surgical treatment for Hirschsprung′s disease were randomly divided into treatment group（12 patients） and control group（15 patients）, during the year of January 2000 and January 2011. The treatment group was treated by conventional therapy combinded with somatostatin, while the control group was only treated by conventional therapy. The time needed for disappearance of abdominal bloat, vomit and healing was observed and evaluated. Results　Time needed for the disappearance of abdominal bloat, vomit and average curative time were significantly shorter in treatment group than in control group. Conclusion　Somatostatin may overall inhibit secretion of digestive juice, mitigate intestinal expansion and ischemic change, significantly improve the clinical symptoms of enterocolitis after surgical treatment for Hirschsprung′s disease, and improve the success rate of conservative treatment.]]> 2018/6/28 8:51:28 DENG Hong-qiang, WU Hong-gen 476true ［Abstract］　Objective　To explore the connection between carotid plaque and cerebral infarction by color Doppler ultrasonography.Methods　Color Doppler ultrasonography was used for the examination of the carotid of 225 patients with cerebral infarction to discover whether there were carotid plaques or not. If there were carotid plaques, measured the thickness of the carotid artery intima-media membrane, the size of plaques, blood vessel hemodynamic parameter and observed whether the blood vessel became narrow.Results　Among the 225 patients with cerebral infarction, color Doppler ultrasonography showed increasing thickness of carotid artery intima-media membrane combined with plaques forming in 197 patients. Plaques appeared mostly in the crotch of common carotid artery, among which flat plaques were found in 78 cases, soft plaques in 64 cases, ulcerous plaques in 31 cases, and tough plaques in 24 cases.Conclusion　The formation of atherosclerostic plaque in carotid arteries had close relationship with the occurrence of cerebral infarction. Applying color Doppler ultrasonography to the examination of carotid atherosclerosis has clinical significance in prognosticating and treating cerebral infarction.]]> 2018/7/2 15:40:24 LIN Jian-jun 475true ［Abstract］　Objective　To explore the effects of the Silagum polysiloxane impression material in the repair of the all ceramic crown and bridge.Methods　The Silagum polysiloxane impression material was used for making 77 work impressions,57 un-work impressions were made by alginate impression material.Results　All the work impressions were eligible while there were 6 un-work impressions not eligible at the first time.Conclusion　The effects of the Silagum polysiloxane impression material in the repair of the all ceramic crown and bridge is satisfactory.]]> 2018/7/2 15:40:24 ZHONG Ai-xi,PENG Li-hui,PAN Xiao-bo,et al. 474true ［Abstract］　Objective　To explore the status of mycoplasma infection in female genital tract and drug susceptibility, drug resistance.Methods　The culture and antibiotic susceptibility testing for vaginal secretions was performed by mycoplasma culture kit in 281 women diagnosed as mycoplasma infection.Results　In the 281 specimens, 87 cases of mycoplasma-positive (28.8%) was showed.Among which, Ureaplasma urealyticum (Uu) was detected in 66 cases (75.9%), Mycoplasma hominis (Mh) in 7 cases (8.0%) and Uu+Mh mixed infection in 14 cases(16.1%). The sensitive rates were in descending order of doxycycline(92.0%), josamycin(90.8%),clarithromycin(82.8%),minocycline(75.9%); the resistance rates were in ascending order of azithromycin(89.7%), erythromycin, sparfloxacin, levofloxacin (94.3%),ofloxacin(98.9%), norfloxacin (100.0%).Conclusion　In female genital infection, Uu was the first, followed by Uu+Mh mixed infection. In the treatment of mycoplasma infections, antibiotics should be selected based on susceptibility testing of antibiotics. Doxycycline, josamycin, clarithromycin, and minocycline should be as the preferred medication.]]> 2018/4/27 8:24:40 CHENG Xian-gui, CHEN Yue, DENG Chao-ying,et al. 473true ［Abstract］　Objective　To investigate the incidence and correlative factors of rheumatoid arthritis associated interstitial lung disease (RA-ILD).Methods　The complete medical records of 352 in-patient with rheumatoid arthritis (RA) were retrospectively analyzed. These in-patients were divided two groups: the first group was patients with RA-ILD(RA-ILD group) and the second without RA-ILD(no ILD group). Correlative clinic factors were analyzed by the comparative method.Results　The total incidence rate of RA-ILD was 5.1% in these in-patients with RA from December 2005 to October 2007. Monofactorical analysis showed that the correlative factors included age，the abnormal level of immunoglobulin G in serum and the level Ⅲ/Ⅳ damage on hand in X-ray；Multifactoical analysis indicated that the correlative factors were age and the abnormal level of immunoglobulin G in serum.Conclusion　The incidence rate of RA-ILD is higher，and it is the results of multiple factors.]]> 2018/5/14 8:34:42 MO Yi,ZHAO Cheng 472true ［Abstract］　Objective　To investigate the clinical significance and diagnostic value of the concentrations of plasma NT-proBNP and BNP in children with bronchiolitis and acute congestive heart failure(AHF).Methods　The concentration of plasma NT-proBNP and BNP were determined in the children with bronchiolitis (n=60,among the children 27 in AHF group,33 in controls) by enzyme-linked-immunosorbent serologic assay(ELISA), and LVEF were measured by two-dimensional echocardiography.Results　The plasma concentrations of NT-proBNP and BNP were much higher in AHF children than those in controls(without AHF)(P<0.01). The NT-proBNP and BNP levels in AHF group had negative correlation with LVEF(r=-0.62,P<0.01; r=-0.39,P<0.05).Conclusion　Plasma NT-proBNP and BNP level may be the more valuable laboratory plasma marker for prognosis and diagnosis of bronchiolitis with acute congestive heart failure.]]> 2018/5/14 8:34:42 ZHANG Yuan-feng,MA Shao-chun 471true ［Abstract］　Objective　To explore the value of PORT score in the evaluation of prognosis of elderly patients with community acquired pneumonia（CAP）. Methods　The clinical data of 139 elderly paitents with CAP was prospectively analyzed. According to the prognosis, the patients were divided into survivors and non-survivors groups, and the level of PORT score was calculated. Next, according to PORT score,patients were divided into ≤70 group,71～90 group,91～130 group and >130 group, the mortality rate were observed.Results　The level of PORT score was higher in non-survivors group than that in survivors group (P<0.01). Mortality rate in ≤70 group,71～90 group,91～130 group and >130 group were 10.0%,13.9%,32.2%和67.6%(P<0.01). The sensitivity, specificity and the diagnostic value of PORT score were 79.2 %, 69.2% and 105, respectively,and the area under the ROC curve was known to be 0.803 (95%CI:0.725～0.881,P=0.000).Conclusion　PORT score is a good indicators for prognosis of elderly patients with CAP.]]> 2018/5/14 8:34:42 HU Guo-ping,YU Yan,LIANG Wei-qiang,et al. 470true ［Abstract］　Objective　To observe the clinical efficacy of application of two kind of cutaneous nerve nutrient vessels flap of lower extremity in repair of tissue defects in distal leg and ankle.Methods　The wounds in the distal leg and ankle were repaired by flexibly choosing the saphenous nerve or the sural nerve nutrient vessels flaps according to the angle and distance of the transferring. The preoperative Doppler was using for clearing perforating branch location.The flap axis was set according to the nerve walking line. The flap was separated at the deep side of the deep fascia. The saphenous nerve or the sural nerve and their accompanying vascular nework were included in the flaps.Then the flap was transferred for wound repair. The donor site directly closed, or repaired by skin graft.Results　In more than three years,these flaps were used for repairing the defects in the lower limbs and foot and ankle defects in 38 patients.The flaps in 33 patients survived completely, in the remaining five patients, there was varying degrees of distal necrosis.Of them, two patients were cured by dressing, three patients were cured by debridement and skin grafting.Conclusion　Saphenous nerve and the sural nerve nutrient vessels retrograde skin flap have the advantages of precise blood supply, simple anatomy, and is able to meet the needs of repair of tissue defects in the distal leg and ankle and is suitable for application in the primary hospital.]]> 2018/5/14 8:34:42 YANG Li,ZHU Xiao-ping 469true ［Abstract］　Objective　To analyze the epidemiological characterization of hand-foot-and-mouth disease in Qinzhou city from 2009 to 2011, aimed to provide basis for prevention and control of hand-foot-and-mouth disease.Methods　Characterization of descriptive epidemiology of patients with hand-foot-and-mouth disease were analyzed according to the National Electronic Disease Surveillance System in Qinzhou city from 2009 to 2011.Results　9 580 cases were reported in Qinzhou city,63 cases of serious conditions included. There was no death case. Annual incidence ranged from 39.47/100000 to 204.19/100000, showing a V distribution. The morbidity in male was higher than that in female. Hand-foot-and-mouth disease mainly occurred in scattered children and children in kindergarten, aging from 0～5 years old.Among them, the morbidity of children under 3 years old was 82.66%.The positive rate of EV71 was 81.61% according to the etiology detection. Hand-foot-and-mouth disease mainly occurred from April to June.Conclusion　The epidemiological characteristics of hand and mouth disease in Qinzhou from 2009 to 2011,were whole high incidence,multi-points,wide range and local outbreak, there was s significant age difference,gender,occupation.Preventing the children under 5 years old from hand-foot-and-mouth disease is the key to control the hand-foot-and-mouth disease.]]> 2018/5/14 8:34:42 LIANG Ye-bang 468true ［Abstract］　Objective　To analyze the correlation factors of macrosomia in order to avoid its occurrence and provide a reliable theoretical basis for intervention. On the other hand, to explore the mode of delivery and treatment scheme of macrosomia in order to reduce maternal injury and improve the prognosis of macrosomia. Methods　The clinical data of 318 macrosomic infants who were born in the people′s Hospital of Guangxi Zhuang Autonomous Region were analyzed retrospectively from January 2007 to March 2012.These data included pregnant women′s raise of weight, blood glucose, modes of delivery, complications, weight of infants, neonatal birth injury, neonatal asphyxia and hypoglycemia of neonates.Results　The correlation factors of macrosomia included hereditary factor, pregnant women′s weight and stature, abnormal glucose metabolism, postterm pregnancy, race, district, habits of life and economic status, parity, male fetus and polyhydramnios factors.Conclusion　Paying close attention to the correlation factors of macrosomia, early prevention, adopting appropriate mode of delivery can reduce the occurrence of macrosomia and its related complications.]]> 2018/5/14 8:34:42 WU Hua, CHEN Chang-yi, LI Jing 467true ［Abstract］　Objective　To study the curative effect of using vacuum sealing drainage, external fixation and stamp skin grafting in the treatment of upper limbs open fracture with soft tissue defect.Methods　From January 2009 to August 2011, 16 patients with upper limbs open fracture with soft tissue defect in the hospital were cured by external fixation after wound debridement. The wounds were covered with VSD materials, then linked to the closed negative pressure attracting device, then closing wound with stamps skin grafting.Results　The result of this surgical method were satisfied. The wounds of 16 patients all healed finally. Six patients′ wounds were infected. All patients were followed up for 6 months to 1 year and 6 months (with an average of 8 months). Thirteen cases showed bone primary union in 3 months and 3 cases showed delayed union in 6 months. The average time of fracture healing was 4.6 months.Conclusion　This method treating upper limbs open fracture with soft tissue defect by using vacuum sealing drainage, external fixation and stamp skin grafting can fix fractures effectively and quickly. Patients treating with this surgery could exercise the affected limbs early. At the same time wounds were closed safely and effectively. Focal infection were limited with the help of VSD. This condition promoted the fracture healing. The granulation tissue were fresh after VSD. The skin lived easily and was got conveniently. This operation is a convenient and effective treatment method for treating upper limbs open fracture with soft tissue defects.]]> 2018/5/14 8:35:38 HUANG Wen-wen, YIN dong, PENG hao, et al. 466true ［Abstract］　Objective　To evaluate the effect of Evidence-based medicine (EBM) on cardiothoracic surgery teaching.Methods　The teacher presented questions according to the clinical cases. The students were asked to find the best solutions to the questions by looking into books and searching articles through the internet and library.Results　We found that most students were improved in clinical and research ability.Conclusion　Our findings show that EBM has good influence on clinical teaching in ways of enhancing the research ability and clinical thinking.]]> 2018/5/21 9:01:32 LEI Bin-feng, XIAN Lei, GUO Jian-ji 465true ［Abstract］　Objective　To investigate the relationship among the platelet count,the plasma levels of fibrinogen and the advanced Non-small cell lung cancer,and its clinical significance.Methods　The platelet count and the plasma levels of fibrinogen were detected in 80 patients with advanced non-small cell lung cancer and 30 normal controls.Results　The platelet count and the plasma levels of fibrinogen of patients with advanced non-small cell lung cancer were significantly higher than those of normal congtrols(P<0.05). The platelet count and the plasma levels of fibrinogen in the patients with advanced non-small cell lung cancer were not related to histological classification, but the platelet count significantly higher in the stage Ⅳ than in the stage Ⅲ.Conclusion　For the patients of lung cancer and clinical suspicion of lung cancer, the platelet count and the plasma levels of fibrinogen has important significance for the diagnosis and prognosis judgment of the disease.]]> 2018/5/21 9:01:32 ZHANG Can-hui,XUE Qing,JIAO Wei-ke, et al. 464true ［Abstract］　Objective　To explore the change of blood zinc and the curative effect of zinc supplementation treatment in persisting diarrhea children.Methods　The peripheral blood of 76 persisting diarrhea children in our hospital and 213 healthy children who had a physical examination in Child′s Health Care from 2007 to 2010 were collected.The blood zinc was determined according to age groups, blood level of zinc was compared between two groups. And persisting diarrhea children were randomly divided into zinc supplementation treatment group(40 cases), and routine therapy group(36 cases). the routining therapy group were given montmorillonite powder, micro-ecological agents and fluid infusion treatment, etc; Zinc supplementation treatment group were given oral zinc gluconate tablets 20 mg/d (children below 6 months, 10 mg/d) based on routine treatment for 14 d.The blood level of zinc was detected after treatment. After discharge,3 months, follow-up visit were given to persisting diarrhea children to observe the diarrhea frequency and weight gain, etc.Results　（1）Zinc level of persisting diarrhea children was obviously lower than that of healthy children of the same age (P<0.01);（2）Total effective rate was 95.0% in the zinc supplementation treatment group and 77.8% in the routine therapy group, respectively, having significant difference (P<0.05)；（3）The average course of treatment were（8.3±2.8）d in the zinc supplementation treatment group and （11.6±3.1）d in the routine therapy group (P<0. 01);（4）After treatment there was no significant difference between blood zinc between the zinc supplementation treatment group and health control group (P>0. 05);（5）Three months after discharge, diarrhea recurrence were （2.3±1.1）times in zinc treatment group and （4.6±2.3）times in routine therapy group (P<0. 01);（6）Zinc supplementation can increase weight of the children with malnutrition.Conclusion　Blood zinc level of persisting diarrhea children was lower, zinc supplementation can increase the clinical efficacy and shorten the period of treatment.]]> 2018/5/21 9:01:32 LI Nian 463true ［Abstract］　Objective　To explore the risk factors for death in AIDS patients complicated with in Penicilliosis Marneffei(PSM).Methods　Using the historical cohort study method, Three hundred and seven cases of AIDS patients complicated with Penicilliosis marneffei treated in Guangxi Longtan hosipital from January 2008 to December 2009 were investigated, a multivariate Logistic regression analysis was used for screening the risk factors for death.Results　There were 226 patients in the survival group and 81 patients in the death froup, with a mortality rate of 26.38%, including 11 patients with relapse, with recurrence rate of 3.58%. The univariate logistic regression analysis showed: routes of infection, treatment options, HAART treatment, complicated with bacterial or other fungal pneumonia, complicated with Pneumocystis carinii pneumonia (PCP), toxic hepatitis, leukopenia, thrombocytopenia, decreased albumin, elevated blood urea nitrogen, serum total bilirubin were associated with risk factors for death. The multiple factors analysis showed, implementation of fluconazole and amphotericin B treatment scheme was protective factors; complicated with PCP, thrombocytopenia, elevated blood urea nitrogen, total bilirubin was high risk factors.Conclusion　It will be significant to reduce the mortality in the future through this study, which will provide some suggestion to take effective treatment and control measures for the doctors.]]> 2018/5/28 8:15:14 LI Fang, GENG Wen-kui, DENG Xiao-jun, et al. 462true ［Abstract］　Objective　To explore the role of the serum IL-6 and C-reactive protein(CRP) in pathogenesis of progressive ischemic stroke.Methods　The levels of serum IL-6 and CRP in different stages in 80 patients with acute cerebral infarction were determined by double-antibody sandwich enzyme-linked immunosorbent assay and transmission turbidimetry, and the development of progressive stroke was determined on the basis of the clinical neurological deficits scale (NDS) score. The other 40 healthy volunteers were used as control group.Results　Of 80 patients with acute cerebral infarction progressive stroke were found in 27 patients (33.75%) within 7 days of stroke. The levels of IL-6 and CRP in peripheral blood at 1st d,3rd d,7th d,14th d after stroke in patients with progressive stroke were significantly higher than that in patients without progressive stroke(P all <0.05).There was no significant difference in levels of IL-6 and CRP at 14th d between progressive stroke group and normal control group(P>0.05).IL-6, CRP were risk factors of progressive stroke.The levels of IL-6 and CRP on the first day were positively correlated with the body temperature, blood white cell count, plasma fibrinogen on admission (correlation coefficient r=0.87,0.66,0.51,P all <0.01).Conclusion　The increase of serum IL-6 and CRP were closely related to progressive ischemic stroke, and may play an important role in the pathogenesis of ischemic stroke. Monitoring the levels of serum IL-6 and CRP has a great significance for monitoring conditions of disease activity and severity.]]> 2018/5/28 8:15:14 SHANG GUAN-wen 461true ［Abstract］　Objective　To explore the clinical effect of compound glycyrrhizin tablets combined narrow spectrum ultraviolet B in the treatment of palmoplantar pustulosis.Methods　Sixty-six patients were randomly divided into 3 groups(n=22 in each group): treatment group was treated with compound glycyrrhizin tablets and narrow spectrum ultraviolet B and control 1 group was treated with compound glycyrrhizin tablets and control 2 group narrow spectrum ultraviolet B. Four weeks was consisted as one treatment course and examination was made before treatment,at the fouth weekend and eighth weekend affer treatment respectively.Results　After 4 weeks,the cure rate of treatment group, control 1 group and control 2 group were 40.91%、18.18% and 13.64% respectively,and the total effective rate of the three groups were 72.73%、40.91% and 36.36% respectively, After 8 weeks,the cure rate of treatment group, control 1 group and control 2 group were 72.73%,31.82% and 22.73% respectively, and the total effective rate of the three groups were 90.91%,63.64% and 54.55% respectively. Treatment group had higher cure rates and total effective rates compared with that of group control 1 and 2 at the 4 weeks and 8 weeks treatment with significant difference(all P<0.05).Conclusion　Compound glycyrrhizin tablets combined with narrow spectrum ultraviolet B were safe and effective in the treatment of palmoplantar pustulosis.]]> 2018/5/28 8:17:41 ZHAO Xiao-fang 460true ［Abstract］　Objective　To study the clinical significance of serum cholinesterase in patients with chronic hepatitis B virus.Methods　Totally 317 patients with chronic hepatitis B virus were randomly assigned to a chronic hepatitis B group (n=111),a liver cirrhosis group (n=108) and a liver cancer group (n=98),and the control group was composed of 110 with healthy cases without liver and renal chronic diseases. the serum cholinesterase, ALT, ALB, TBIL, Chol were desermined.Results　The serum cholinesterase of chronic hepatitis B group, liver cirrhosis group and liver cancer group was lower than that of control group, in liver cirrhosis group and liver cancer group was more lower, the liver cirrhosis of Child-Pugh C class was the lowest, the differences between Child-Pugh A class and Child-Pugh B class were significant (P<0.05).Conclusion　Determination of levels of serum cholinesterase might reflect the degree of liver inflammation and fibrosis in patients with chronic hepatitis B virus,the change of cholinesterase is very important factor influencing prognosis.]]> 2018/5/28 8:17:42 DENG Zhi-hai 459true ［Abstract］　Objective　To study the effect of lipoprotein(a)(Lp-a) in the occunence and development of coronary heart disease.Methods　The serum Lp-a concentration in 34 cases of myocardial infarction (AMI),123 cases of non myocardial infarction coronary heart disease and 163 cases of non coronary heart disease were determined.Results　Serum Lp-a concentration was （51.17±41.99）mg/dl,（28.90±29.61）mg/dl,（12.54±8.50）mg/dl in AMI group, non myocardial infarction coronary heart disease group and non coronary heart disease group respectively. There were statistical significant difference among the 3 groups （P<0.01）.In non coronary heart disease group, they were （22.84±3.73）mg/dl and （33.33±3.66）mg/dl in local narrow subgroup and diffuse narrow subgroup respectively. And （22.04±3.25）mg/dl and （31.74±3.49） mg/dl in mild narrow subgroup and moderate or more narrow subgroup. There were statistical significant difference between every two groups.Conclusion　The increase of serum Lp-a concentration may promote the occurrence and development of coronary heart disease. The Lp-a concentration gradually increase with the increase of coronary artery pathological changes, and its increase may be a risk factor for coronary heart disease.]]> 2018/5/28 8:17:42 HUANG Xian-nan, LAN Jing-sheng, LIU Yan, et al. 458true ［Abstract］　Objective　To study the curative effect of treating early avascular necrosis of femoral head by grafting sartorius muscle iliac bone flap.Methods　Since December 2006 to February 2010, 56 cases of avascular necrosis of femoral head (male 30 cases, female 26 cases) in the hospital were study. All cases were confirmed after comprehensive analyzing its clinical manifestations and image data. Fifty-six cases were cured with grafting sartorius muscle iliac bone flap into groove of femoral head and neck.Results　The follow-up of the 56 patients during 8 months to 36 months (with an average of 18 months) revealed that based on the Harris evaluation for the hip function，the scores preoperative was (38.3±4.1) points and 12 month postoperative scores was (85.2±6.3) points. The result of T chest showed （P<0.01）. The results showed excellent therapeutic result in 41 cases, good in 11 cases, fair in 2 cases and poor in 2 cases, the excellent and good rate was 92.8%. Conclusion　This method treating early avascular necrosis of femoral head by grafting sartorius muscle iliac bone flap has not only reconstructed the blood circulation of femoral head, but also provided autologous live bone which can alternative necrotic bone. Sartorius muscle iliac bone flap can be acquired conveniently.So it is a good treatment method for treating early avascular necrosis of femoral head.]]> 2018/6/4 8:29:26 LIU Chao,PENG Hao,YIN Dong,et al. 457true ［Abstract］　Objective　To study the normal range of SCA3/MJD gene (CAG)n repeats in Han population in Guangxi region.Methods　The (CAG)n repeats polymorphism of SCA3/MJD gene was detected by fluorescence-polymerase chain reaction (PCR) and capillary electrophoresis (CE).Results　The normal ranges of (CAG)n of SCA3/MJD gene varied from 13 to 34 repeats, including a total of 17 alleles. The most common repeats number was 13 repeats, allele frequency was 52.00%, heterozygosity was 69.33%.Conclusion　SCA3/MJD gene (CAG)n repeats in the normal population in Guangxi showed polymorphism. There are regional differences in the normal range of variation.]]> 2018/6/4 8:29:26 LUO Man, WANG Jin, LI Gui-bing, et al. 456true ［Abstract］　Objective　To investigate the ultrasonic features and scan skills in the diagnosis of ovarian torsion using color Doppler ultrasound.Methods　Fifteen patients with ovarian torsion were routinely detected by ultrasound system with curved transducer, endocavity transducer, and linear transducer. The sonographic findings of ovarian torsion were completely evaluated, including gray-scale ultrasound and color Doppler ultrasound. The results were compared with the operation.Results　Ultrasonic features of ovarian torsion included unilateral enlarged ovary (15 cases), uniform peripheral cystic structures (11 cases), a coexistent benign mass (12 cases) with the affected ovary, and twisted vascular pedicle (6 cases). Lack of arterial or venous flow was demonstrated in 12 cases. And venous flow was demonstrated in 3 cases by color Doppler ultrasound.Conclusion　Ultrasonography is the primary imaging modality for accurate evaluation of ovarian torsion. Twisted vascular pedicle and central venous flow demonstrated with color Doppler ultrasound may indicate that the ovary is viable.]]> 2018/6/4 8:29:26 CHEN Li-rong, ZHANG Bu-lin, QING Dong-qiong, et al. 455true ［Abstract］　Objective　To explore the therapeutic effects of danhong injection and its influence on the concentration level of c-reactive protein and hemorheology in patients with acute exacerbation of chronic cor pulmonale.Methods　Eighty patients with acute exacerbation of chronic cor pulmonale were randomly divided into the treatment group and the control group. Both groups were treated by using of oxygen, anti-inflammatory, cardiac diuretic, vasodilatation, correcting acid-base balance and electrolyte imbalance. At the same time, the treatment group was added danhong injection, once a day, for 14 days. The levels of c-reactive protein, hemorheology (D-dimer, hemoglobin, fibrinogen, hematocrit value) were determined before the entry into the trial and after 14 days of the trial, respectively.Results　After 14 days, the therapeutic effects of treatment group was better than that of control group (P<0.05). The concentration level of c-reactive protein and hemorheology(D-dimer,hemoglobin,fibrinogen,hematocrit value) were significantly lower in both groups (P<0. 05).However, the concentration level of c-reactive protein and hemorheology in treatment group were significantly lower than that in control group (P<0.05).Conclusion　Danhong injection can reduce the concentration level of the c-reactive protein and hemorheology significantly and plays an important role in increasing therapeutic effect and improving hypercoagulable state in patients with acute exacerbation of chronic cor pulmonale.]]> 2018/6/4 8:30:03 WANG Hua,HUANG Ling,CHEN Ping,et al. 454true ［Abstract］　Objective　To explore the important role of interleukin-6 (IL-6) and C reaction protein (CRP) in onset and development of mycoplasma pneumonine pneumonia (MPP) and judge the severity and prognosis by studying the changes of IL-6 and CRP in peripheral blood of children with MPP at acute stage.Methods　Forty-seven children with MPP were divided into myocardial injury group and non-myocardial injury group according to myocardial enzymogram. The serum levels of IL-6 with the method of enzyme-linked immunosorbent assay (ELISA) and CRP with turbidimetric assay in automatic biochemical analyzer were determined in those patiets as well as 28 controls.Results　The levels of serum IL-6 and CRP in children with MPP were higher than those in the controls (P<0.01). The levels of serum IL-6 and CRP in the myocardial injury group were higher than those in the non-myocardial injury group (P<0.01). The level of serum IL-6 was positively correlated with the level of serum CRP （r=0.690,P<0.001）.Conclusion　The concertration of IL-6 and CRP in children with MPP at acute stage increased significantly and there were significant positive correlation between them, indicating acute phase of MPP in children associated with a clear inflammatory response. Furthermore the levels of IL-6 and CRP in children with myocardial injury were higher than those without myocardial injury, suggesting that the changes of levels of IL-6 and CRP may be associated with disease severity.]]> 2018/6/4 8:30:03 CHEN Yun-zhi,TIAN Dong 453true ［Abstract］　Objective　To study the serum levels of C-reactive protein (CRP) in essential hypertensive patients with extracranial carotid atherosclerosis. Methods　A high-resolution extravascular B-mode ultrasonographic measurement were used in 92 essential hypertensive patients. The carotid atherosclerosis was identified as intimal-medial thickness≥1.0 mm or finding of carotid plaques. Enzyme-linked immunosorbent assay was used to examine the level of serum C-reactive protein.Results　Carotid atherosclerosis were identified in 48 participatients. There was no difference in carotid atherosclerosis prevalence between the male and female patients, however, the serum levels of CRP in essential hypertensive patients with extracranial carotid atherosclerosis were higher than those in essential hypertensive patients without extracranial carotid atherosclerosis ［（2.1±1.5)mg/ml vs (3.2±2.4)mg/ml］, (P<0.05）.Conclusion　The serum levels of CRP in essential hypertensive patients was associated with extracranial carotid atherosclerosis.]]> 2018/6/4 8:30:03 TANG Zhen, CHEN Jian-ye, ZHANG Xiu-yun, et al. 452true ［Abstract］　Objective　To investigate the clinical diagnosis and treatment methods for rotavirus infectious diarrhea comblined with multiple organ function damage.Methods　Forty infants with rotavirus infectious diarrhea complicated by multiple organ function damage treated in paediatric ward of our hospital from December 2010 to March 2011 were selected. After admission, fresh stool sample were collected for detecting rotavirus antigen, and stool culture was performed, and the function of liver and kidney, myocardial enzyme, blood electrolyte and C-reactive protein were detected.Results　There were respiratory symptoms at different degree, abnormal changes in urine routine, myocardial enzyme, electrolyte and CRP in 40 infants with rotavirus infectious diarrhea.Conclusion　The infants with rotavirus infectious diarrhea are easily complicated by extraintestinal organ function damage, detecting timely and early treating are the key of prevention and treatment.]]> 2018/6/4 8:30:03 CHEN Hong-bing,LIAO Li-hong,LIU Juan,et al. 451true ［Abstract］　Objective　To investigate the common sensitizing agents in patients with chronic urticaria by MORA and assess the clinical efficacy and safety of MORA combined with epinastine hydrochloride for chronic urticaria.Methods　Sixty-five patients with chronic urticaria were randomly divided into two groups: The treatment group received the treatment of MORA combined with epinastine hydrochloride; The control group received epinastine hydrochloride simply. The course of treatment were four weeks, before and after the course their efficacy were assessed.Results　The positive rate of dust mite, which varied from 39.3% to 50.0%,was the highest among the tested allergens, followed by that of mound 35.7%,food additives 35.7%, textile detergent dye 32.2%, fish 28.6% and bacteria 28.6%.After treatment obvious dicreases in clinical scores were found in both groups. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). Conclusion　The treatment of MORA combined with epinastine hydrochloride could be an effective and safe choice for patients with chronic urticaria, worthy of more clinical study and promotion.]]> 2018/6/22 16:33:56 MEI Ce-fang, WEN Jing, OU YANG-lie, et al. 450true ［Abstract］　Objective　To investigate the clinical features of children with hemophagocytic syndrome (HPS).Methods　The clinical and laboratory data of 26 cases with infection-associated HPS were analyzed retrospectively.Results　In all the 26 cases of HPS, 17 cases were infection-associated（65.38%), 3 cases were not infection-associated (11.54%), 6 cases were unknown causes (23.08%).The main clinical characteristics of the disease in this group were sustaining fever (100.00%), hepatomegaly (84.62%), splenomegaly (92.31%). Laboratory tests showed decrease of peripheral white blood count (76.92%), of blood platelet (88.46%), of hemoglobin (80.77%), hemophagocytes in bone marrow slides (100.00%).Conclusion　The main manifestations of HPS are continuing hyperpyrexia, hepatomegaly and splenomegaly ; the laboratory findings include decrease of white blood count, hemoglobin or blood platelet, hypertriglyceridemia, liver disfunction, elevation of serum ferritin, and the hemophagocytes in bone marrow.]]> 2018/6/22 16:33:56 ZHANG Hui, MO Wu-ning, LI Ping 449true ［Abstract］　Objective　To explore the clinical characteristics of moyamoya disease associated with intracranial aneurysms,and to provide evidence for clinical treatment and diagnosis.Methods　A retrospective analysis of the clinical data of 8 patients with Moyamoya disease associated with intracranial aneurysms was performed, including the clinical symptoms, distribution of aneurysms and treatment method.Results　Among the 8 patients, 4 presented with SAH, 2 patients presented with ischaemic stroke,and 2 patients presented with ventricle hemorrhage. Distribution of the 8 aneurysms was:4 around the circle of Willis,2 on the top of base artery,1 in vertebray artery，1 in choroid anterior artery. Five patients received intervention embolization procedures with a favorable outcome.Conclusion　According to the distribution of the aneurysms, the different treatment can be applied. Intervention embolization procedures can be applied to aneurysms in the artery of moyamoya disease or posterior circulation aneurysm,and the treatment for aneurysms found on the collateral vessels(peripheral artery) need a further discussion, because no appropriate surgical method to treat it is available now.]]> 2018/6/22 16:33:56 MAO Zhong-chen, FU Zhi-xin,GAO Tiang 448true ［Abstract］　Objective　To validate the efficacy and safety of Ginaton in the treatment of acute ischemic stroke.Methods　Fifty patients (37 male and 13 female) with acute cerebral infarction were treated with routine therapy plus Ginaton sequential therapy for 45 days,in an open,self-control study.Results　The neurological deficit scores (neurological functional deficit scale,NFDS) on the 14 days and 45 days of treatment were significantly lower than that before treatment （P<0.05）,and the scores on the 45 days of treatment was significantly lower than the 14 days of treatment（P<0.05). The efficiency of treatment on the 14 days of treatment was 82%,that on the 45 days of treatment was 96%.Conclusion　Ginaton is significantly effective and highly safe in the treatment of acute ischemic stroke,which has been widely used for the prevention and treatment of acute ischemic stroke.]]> 2018/4/8 15:34:47 LU Fang, ZHEN Jin-ou 447true ［Abstract］　Objective　To observe the effect of sedation and analgesia on cerebral metabolism in patients with severe subarachnoid hemorrhage.Methods　Thirty-four patients with severe subarachnoid hemorrhage was chosen, and the way of self-control study was used. Conventional hemostasis, dehydration and anti-vasospasm therapies were employed after admission. According to the level of pain and irritable of patients,fentanyl was associated with propofol and midazolam respectively for therapy.The carotid venous oxygen saturation were detected before treatment,during treatment,and at 1 hour,3 hours and 6 hours after the end of treatment.Results　There was no significant change in carotid arterial oxygen saturation before and after treatment.After treatment,jugular venous oxygen saturation and central venous oxygen saturation were lower than those before treatment,returned to normal at 2 hours after treatment and gradually decreased to close to the level before treatment at 1 hour,3 hours and 6 hours after the end of treatment.Conclusion　Analgesia and sedation could reduce cerebral oxygen metabolism at the same time reducing the systemic metabolism.]]> 2018/4/8 15:34:47 MAO Zhong-chen, FU Zhi-xin, JIA Yong-lin, et al. 446true ［Abstract］　Objective　To investigate the diagnostic value of serum tumor markers neuron specific enolase (NSE),tokeratin 19 fragment (CYFRA21-1), carcinoembryonic antigen (CEA),carbohydrate antigen (CA125) in lung cancer.Methods　The NSE,CYFRA21-1,CEA,CA125 contents of 70 cases of lung cancer,50 cases of benign disease and 50 cases of healthy controllers were detected by electrochemiluminescence immunoassay(ECLIA) and analyzed.Results　In comparison of 4 tumor markers among three groups,the difference was statistically significant (all P<0.01). The average of the NSE,CYFRA21-1,CEA,CA125 of lung cancer group were higher than those of benign lung disease and healthy controllers (all P<0.01). The level of NSE in patients with small cell lung cancer was higher than those of other subtypes (all P<0.01). The level of CYFRA21-1 in patients with squamous cell carcinoma was higher than those of other subtypes (all P<0.05). The sensitivity of NSE were most high in four tumor markers,which was 87.14%.The sensitivity of the combined detection of more than one of the four tumor markers were most high,which was 98.57%, which was superior to signal assay. The sensitivity of NSE in small cell lung cancer was higher than those of other subtypes. The sensitivity of CYFRA21-1 in squamous cell carcinoma was higher than those of other subtypes. The sensitivity of CEA adenocarcinoma was higher than those of other subtypes.Conclusion　Tumor markers NSE,CYFRA21-1,CEA,CA125 for lung cancer diagnosis,differential diagnosis and classification has very important clinical significance.]]> 2018/4/11 8:05:21 HE Wang-jiao 445true ［Abstract］　Objective　To compare the anesthetic effect between propofol-fentanyl and propofol-remifentanil in painless fiberoptic bronchoscopy.Methods　Forty patients undergoing elective painless fiberoptic bronchoscopy were randomly divided into 2 groups: Fentanyl group (group F) received intravenous injection of propofol 1.5 mg/kg and fentanyl 0.5 μg /kg; Remifentanil group (group R) received intravenous injection of propofol 1.0 mg/kg and remifentanil 0.3 μg /kg.Results　In two groups of patients were successfully completed the check. The dosage of propofol was lower used and waken time was shorter in group R compared with group F（P<0.05）.Conclusion　Propofol combined with fentanyl or propofol combined with remifentanil both can satisfy the painless requirements, the two methods are feasible and safe in clinical practice,but the effect of the former is more better.]]> 2018/4/11 8:05:21 LI Guo-feng,WANG Yue-gang,LIU Xin-feng 444true ［Abstract］　Objective　To understand the infection situation and drug resistance of MRSA from respiratory tract.Methods　A total of 263 isolates of staphyloccus aureus from respiratory tract in outpatients and inpatients in Daqing oilfield general hospital from Norember 2010 to October 2011 were analyzed.Results　MRSA accounted for 57.79%(152/263),drug sensitivity result showed that MRSA was sensitive to vancomycin and linezolid and was relatively sensitive to compound sinomin and rifampicin and the resistance rates of MRSA to β-lactam antibiotics, quinolones, macrolides,aminoglycosides were more than 80%.Conclusion　MRSA are highly resistant to multiple antibiotices，either vancomycin or linezolid should be chosen firstly.]]> 2018/4/27 8:23:45 GU Guo-zhong,BAI Yan-ling,YANG Li 443true ［Abstract］　Objective　To evaluate the role of double-stapling technique in low anterior resection for low rectal cancer, investigate the causes of complications and its corresponding of measures prevention and cure.Methods　A retrospective study was conducted on 90 consecutive patients who underwent double-stapled low anterior resection for low rectal carcinoma.Results　The double stapling procedure in 90 patients were successful without operative deaths,anastomotic fistula was found in 5 patients（5.6%）,anastomotic stenosis was in 2 patients（2.2%）.All complication were cured after corresponding treatment.Conclusion　The double stapling technique improves the successful rate in the sphincter-preserving operation of low rectal cancer and effectively redure the incidence of complication.]]> 2018/4/27 8:23:45 ZHANG Rui 442true ［Abstract］　Objective　To explore the related factors of cerebral palsy in twin or multiple pregnancies，and the effect of early intervention on prognosis.Methods　One hundred and fifty nine cases of twin or multiple pregnancy from 86 families in the perinatal period were investigated by retrospective investigation and analysis method, and assessed them by Gesell scale at the same time, the results were comprehensively analyzed.Results　There were 106 cases of cerebral palsy in 159 cases twin or multiple pregnancies, the cerebral palsy rate was 66.7%(106/159). There were 94 cases of cerebral palsy among 143 babies of twin or multiple pregnancies, the cerebral palsy rate was 65.7%(94/143). After the rehabilitation treatment, the cerebral palsy rate was 14.5%(23/159), There were many high risk factors of cerebral palsy, which in turn was premature birth, low birth weight, hyperbilirubinemia, hypoxic ischemic encephalopathy, asphyxia, neonatal pneumonia, hypoglycemia, gestational diabetes, in-vitro fertilization and cesarean section.Conclusion　Twin or multiple pregnancies are prong to premature birth; there were positive correlation between infantile cerebral palsy and their high risk factors. But early intervention could significantly reduce the incidence of cerebral palsy, and the smaller age of rehabilitation therapy, the better results, and the optimal treatment time window was before 6 months age.]]> 2018/1/29 9:17:02 LIU Zhen- ling, HE Shuang, CHEN Fang, et al. 441true ［Abstract］　Objective　To evaluate the application value of transcutaneous oxygen pressure(TcPO₂) monitoring in the diabetic foot amputation surgery.Methods　Retrospective analysis of 68 type 2 diabetic patients with foot amputations was performed. Thirty-two diabetic foot patients in the trial group(group A) were amputated at the level above of 40 mmHg in TcPO₂,and was compared with the control group(group B) in which 36 diabetic foot patients were amputated based on clinical experience. Their prognosis were observed and analyzed.Results　The postoperative wound healing of group A was obviously superior to group B.The amputation complication rate in group A was lower than that in group B.There were significantly difference(P<0.01).Conclusion　TcPO₂ measurement is a guide and reliable index to ascertain the level of amputation, with advantages of less cost, reliable result, and repeatable, simple non-invasive operation.]]> 2018/1/29 9:17:02 CAI Min, LI Hong-yu, YUAN Yan, et al. 440true ［Abstract］　Objective　To explore the clinica1 value of hysteroscopic curettage after uterine artery embolization (UAE) in the treatment of the cesarean scar pregnancy(CSP).Methods　A retrospective analysis of 13 patients of CSP was performed.Results　Except for 1 patient of resection of uterine for patient′s requiring hysterectomy, the remaining 12 patients were treated by uterine artery embolization combined with hysteroscopic uterine curettage and were cured.Conclusion　The interventional therapy can rapidly stop bleading, effectively kill embryo, reduce the risk of bleeding and hysterectomy, and is the effective treatment method of CSP.]]> 2018/1/29 9:17:02 LIU Hui-ping, WANG Ruo-guang, PENG Gui-hua,et al. 439true ［Abstract］　Objective　To observe and analyze the standards of the normal adult splenic multislice spiral CT(MSCT) imaging to provide relevant normal range for clinic and teaching.Methods　One hundred and sixty cases with normal spleen were undergone abdominal MSCT, then 3D imaging was performed, the position of spleen distance between two poles of spleen,the out edges of right and left of spleen,the midpoint of the splenic hailar and the central line of the spine, the diameter of splenic portal vein and splenic length,thickness and width were observed and measured with statistics analysis.Results　Almost splenic upper poles located at the T₁₀ level，lower poles located at the L₂ level and the midpoint of the splenic hailar located at the L₁ level. The values measured on CT of spleen in men were larger than that in women.Except for the distance between the midpoint of the splenic hailar,the out edges of right and left of spleen and the central line of the body and thick of spleen, the most values measured on CT were all of significant statistically(P<0. 05). Along with age increasing, the values measured on CT of spleen in normal adult have a tendency of shrinking.Conclusion　The data of normal adult splenic location, size and shape obtained in this study can be used as the values consulted by clinic diagnosis, treatment and teaching.]]> 2018/2/5 8:39:48 ZI Gang,ZHOU Li 438true ［Abstract］　Objective　To evaluation the relationship between X-ray repair cross-complementing group 1 (XRCC1) single nucleotide polymorphisms （SNPs） and genetic susceptibility to prostate cancer (Pca) risk.Methods　We searched on MEDLINE, EMBASE and OVID, collected and abstracted the case-control studies about XRCC1 codon 194, 280, 399 polymorphisms and genetic susceptibility of Pca; did Meta-analysis by Stata, Odds ratios (ORs) and 95% confidence interval (95%CI) were calculated to evaluate correlation strength; the relation between smoking and Pca was analyzed by SPSS, OR evaluated relative risk of smoking.Results　XRCC1 399 Gln/Gln and XRCC1 280 Arg/His were related with risk for Pca (Gln/Gln vs Arg/Arg: OR=1.27, 95%CI=1.02～1.59; Arg/His vs Arg/Arg:OR=1.66, 95%CI=1.09～2.52), especially Asian Gln/Gln obviously increased risk for Pca (OR=1.52, 95%CI=1.18～1.96); Arg194Trp was not related with risk for Pca. Smoking was a risk factor of Pca (χ²=13.974, P=0.000, OR=1.22).Conclusion　XRCC1 399 Gln/Gln and XRCC1 280 Arg/His were probably related with genetic susceptibility to Pca.]]> 2018/2/5 8:39:48 LIU Fei,ZHANG Hai-feng,JIAO Wei,et al. 437true ［Abstract］　Objective　To understand the component of hospitalized patients with blood disease, in order to provide scientific basic for a reasonable allocation of social health resources and the early protection and early treatment.Methods　The component of the patients in hematology department during from 2004 to 2010 were analyzed and chi-square test was used for statistical analysis and comparison.Results　In the seven years, there were 3 757 patients for the first diagnosis and therapy in the hospital. Annual newly diagnosed patients had greatly increased. The top five of the common blood diseases were ANLL，ITP，Hench-schonlein purpura，AA，Megaloblastic anemia. The difference of disease incidence of ITP，Hench-schonlein purpura，IDA，CML，HL was statistically significant between sex ratio. MM can be found more often in elderly patients，and Hench-schonlein purpura，ALL，AA in the majority with teenagers, IDA in puberty and childbearing age women increased. Megaloblastic anemia had younger and older two peak periods of incidence.Conclusion　During 2004～2010, there is an increasing tendency in annual newly diagnosed patients. The difference of disease incidence was statistically significant between sex ratio. We should strengthen the prevention and education work in blood disease.]]> 2018/2/5 8:39:48 ZHANG Qing-yi, GE Gui-min, YAN Yi-peng 436true ［Abstract］　Objective　To compare the effects of intestinal preparation, reverse drug reactions, bubbles and tolerability among 4 different intestinal preparation methods, in order to seek out simple fast and safe intestinal preparation methods.Methods　Two hundred and forty patients undergoing colonoscopy were randomly divided into 4 groups with 60 cases in each group. Group A received mannital, group B received Macrogol 4000 powder for oral solution, group C received Macrogol 4000 powder for oral solution combined with Mosapride citrate dispersible tablets,group D received oral sodium phosphate. Effects of bowel cleansing, reverse drug reactions and bubbles were observed and compared.Results　The intestinal cleanliness of group C and group D were superior to group A and group B . Among the four groups, group D has the lest rate of reverse drug reactions（P<0.05）. Four groups showed the similar rate of bubbles.Conclusion　Both methods, no matter the combined use of Macrogol 4000 powder for oral solution and Mosapride citrate dispersible tablets,or oral sodium phosphate have better quality of bowel cleansing, and oral sodium phosphate has the lest rate of reverse drug reactions.]]> 2018/2/5 8:39:48 ZHOU Yun,SU Yi-qun,ZHOU Xu-jun 435true ［Abstract］　Objective　To observe the clinical curative efficacy of the interference electric theraphy combined with traction, paraffin therapy, electric acupuncture in the treatment of lumbar disc herniation.Methods　In the observation group,45 patients with lumbar disc herniation were treated by interference electric therapy combined with paraffin therapy, traction, and electric acupuncture; In the treatment group, 45 patients with lumbar disc herniation were treated by electric, paraffin therapy and traction. The treatment effect between two groups was compared.Results　The observation group’s total effective rate was 95.6%, the treatment group’s total effective rate was 84.4%,there were no statisfisially significant difference in totel effective effect between two groups(P>0.05).Conclusion　The curative effect of interference electric therapy with traction, paraffin therapy, and effect acupuncture in the treatment of lumbar disc herniation is remarkable, and is worthy of clinical promotion.]]> 2018/2/5 8:39:26 DONG Jun-cheng 434true ［Abstract］　Objective　To observe the serum zinc levels and the clinical effect of zinc treatment in children with rotavirus(RV) enteritis.Methods　The children with RV enteritis were divided into conventional treatment group and zinc treatment group, with 64 cases in each group. The serum zinc content were detected,and the total effective rate, disappeared time of clinical symptoms and the number of days of hospitalization were compared between two groups.Results　In RV enteritis zinc group, after and before treatment the difference in serum zinc level was significant.After treatment,there was significant difference in serum zinc level between RV enteritis zinc group and conventional treatment group(P<0.05); The difference of total efficiency rate, fever duration, diarrhea duration and hospitalization time between two groups were statistically significant(P<0.05); but there was no statistically difference in vomiting duration between the two groups(P>0.05).Conclusion　RV enteritis has a great influence on serum zinc metabolism, zinc supplementation may be an effective auxiliary method for the treatment and prevention of rotavirus enteritis.]]> 2018/2/5 8:39:26 ZHANG Ji-yong,DONG Guo-qing,ZHANG Ying-biao 433true ［Abstract］　Objective　To study serum levels of brain natriuretic peptide (BNP) and cardiac troponin I (cTnI)in children with rheumatic heart disease.Methods　Serum levels of BNP and cTnI were measured in twenty five children with rheumatic heart disease and twenty five healthy children using ELISA.Results　Mean serum level of BNP and cTnI in children with rheumatic heart disease was significantly higher than that of the control group(P<0.01 or P<0.05). The linear regression analysis showed that the BNP level was positively correlated with the levels of CRP and WBC(r=0.1547,0.1421,P<0.05) in children with rheumatic heart disease.Conclusion　The serum BNP and cTnI levels increased significantly in children with rheumatic heart disease, and are positively correlated with the levels of CRP and WBC.]]> 2018/2/5 8:39:26 WANG Jin-ju, WANG Wen-di, JIANG Yan 432true ［Abstract］　Objective　To evaluate the applied value of transthoracic echocardiography(TTE) in perioperative period of transcatheter closure of ostium secundum atrial septal defects(ASD).Methods　Eighty six patients with ostium secundum ASD waiting for surgical treatment underwent TTE for pre-operative assessment of ASD size and rims on various views, selection of amplatzer septal occluder(ASO), monitoring setting and releasing of occluder in operation and post-operation follow-up.Results　The size of ASD measured by TTE was 5～34（24.4±5.63）mm in 86 patients before operation, the size of selected occluder was 8～40（27.5±7.12）mm. Eighty-one cases were successfully treated with ASO(94.2%), including 2 cases with multiple ASD. Five patients with residual shunt were found immediately after the operation. During the 3 months follow-up,all residual shunts disappeared.Conclusion　Transcatheter closure is a safe and effective method in patients with ostium secundum ASD. TTE have important clinical value in choice of ASD patients and the size of occluder device, monitoring setting and releasing of occluder in operation and evaluation of the treatment efficiency.]]> 2018/2/23 15:16:37 ZHANG Xiao-hong,CHEN Ying,ZHU Dan-ru 431true ［Abstract］　Objective　To explore the clinical and histopathological characteristcs and the diagnosis ststus of seborrheic keratosis(SK).Methods　The clinical datas of 220 patients with SK were analyzed retrospectively.Results　The elderly patients accounted for the majority and males were more than females in patients with SK. SK more occurred in exposed parts than non-exposed parts. The most common pathological type was acanthosis and hyperkeratosis. Clinically, SK was easily confused with nevi, flat warts, common warts, actinic keratoses, basal cell carcinoma, melanoma and so on. The diagnosis depends on the histopathological examination.Conclusion　SK is related to gender, age, and sunlight, histopathological examination is important in the diagnosis and differential diagnosis of SK.]]> 2018/2/23 15:16:37 CHENG Xian-gui, XIE Fang-ming, CHEN-Yue, et al. 430true ［Abstract］　Objective　To investigate optimal concentration of bupivacaine for lumbar anesthesia in undergoing second cesarean section.Methods　Sixty patients who underwent the second caesarean section with spinal-epidural anesthesia were randomly divided into two groups. Every group involved 30 cases. Group A received 7.5 mg of 0.5% bupivacaine for lumbar anesthesia; group B received 7.5 mg of 0.25% bupivacaine. The anaesthetic effects and side effects were compared between the two groups.Results　The effective time, anesthesia level, the operation time and newborn Apgar score had no distinct difference between two groups. The usage rate of lidocaine in group A were less than those in group B(P<0.05). The anaesthetic effects in group A was better than that in group B(P<0.05).Conclusion　0.5% bupivacaine is more effective and safe than 0.25% bupivacaine for lumbar anesthesia in second cesarean section.]]> 2018/2/23 15:16:37 ZHONG Ying, LI Bi-wan, LIANG Jun 429true ［Abstract］　Objective　To investigate clinical features, outcome and laboratory characteristics of thrombotic thrombocytopenic purpura (TTP) and improve diagnostic ability for physicians in TTP management.Methods　The clinical features, treatment and prognosis of 18 TTP patients were retrospectively analyzed.Results　There were 77.8% patients with the triad of TTP, including hemolytic anemia, thrombocytopenia and neurologic abnormalities or had the classical pentad of TTP. All the patients showed the classical pentad of TTP in the process of treatment. Twelve patients accepted plasmapheresis, 75.0% of them achieved complete remission. Six patients without plasmapheresis all died.Conclusion　In order to improve early diagnostic ability, to be active to use plasma exchange therapy and to maximize survival, whether the diagnostic criteria of TTP should be relaxed or not remains further discussion.]]> 2018/2/23 15:17:06 XU Min, DENG Dong-hong, YANG Jie, et al. 428true ［Abstract］　Objective　To explore the correlation of hearing thresholds using click evoked auditory brainstem response(click-ABR) and pure tone audiometry(PTA) with different auditory configurations.Methods　Ten normal hearing adults(20 ears). Sixty-two cases of sensorineural hearing loss were divided into flat type group(24 ears) and steep drop type group(38 ears). The steep drop type group was further divided into four subgroups:1 kHz steep drop type group(5 ears),2 kHz steep drop type group(11 ears),4 kHz steep drop type group(19 ears),6 kHz steep drop type group(3 ears). The response threshold of click-ABR and 0.25,0.5,1,2,4,6,8 kHz hearing threshold of PTA were recorded. The recorded data was analyzed by SPSS V13.0.Results　The linear correlation of 2-frequency(2,4 kHz) pure-tone threshold average and the click-ABR response threshold at normal hearing group,flat type group,1 kHz steep drop type,2 kHz steep drop type coefficients were:0.83 (P<0.01),0.94 (P<0.01),0.97(P<0.01),0.80(P<0.01). 4 kHz steep drop type was:0.16(P>0.05). Because of the 6 kHz steep drop group was fewer, it was no statistically significant.Conclusion　The response threshold of click-ABR correlated with 2-frequency(2,4 kHz) pure-tone threshold average, but can not be understood to be able to use the response threshold of click-ABR accurate to assess 2-frequency(2,4 kHz) pure-tone threshold average. The correction value of the difference between the response threshold of click-ABR and 2-frequency(2,4 kHz) pure-tone threshold average was 36 dB.For the normal hearing group and the flat-type group,it can be accurate assessment of hearing threshold.For hearing threshold assessment of the steep drop type group，the difference between the response threshold of click-ABR and 2-frequency(2,4 kHz) pure-tone threshold average were from 10 dB to 70 dB. Nevertheless, the response threshold of click-ABR as the hearing threshold assessment still has its reference value in the clinical application.]]> 2018/2/23 15:17:06 WANG Tao,LIANG Jian-ping,LU Qiu-tian, et al. 427true ［Abstract］　Objective　To observe the clinical effect of arthroscopic resection of radial head in the treatment of adult Mason Ⅲ radial head fracture.Methods　Twelve patients with radial head fracture were treated with arthroscopic resection of radial head.Results　All patients were followed up for 6～18 months with an average of 10 months. Mild elbow ectopic ossification was found in one patient. No elbow instability and radial nerve injury was found. According to Broberg-Morrey elbow function assessment standard of therapeutic effectiveness，Excellent effect was found in 10 patients, good in 2 patients.Conclusion　Arthroscopic resection of radial head for treatment of adult Mason Ⅲ radial head fracture was less complications compared to traditional radial head resection,and can make more patients doing functional exercises early.It is an effective method for treatment of adult radial head fractures.]]> 2018/2/23 15:17:06 WANG Hong-tao, MI Kun,LIU Wu, et al. 426true ［Abstract］　Objective　To observe the clinical efficiency of topical tazarotene cream combined with local injection of triamcinolone acetonide in the treatment of prurigo nodularis.Methods　One hundred and sixty-eight patients with prurigo nodularis were divided into two groups. Ninety-eight patients of treatment group were given topical 0.1% tazarotene cream combined with local injection of triamcinolone acetonide, however, patients of the control group were only given local injection of triamcinolone acetonide. After eight weeks, the number of lesions and subjective symptom of patients were recorded, and the therapeutic efficiency were compared, and the recurrence and side-effect were also analysed.Results　At the end of 4th and 8th week of treatment course, the therapeutic efficiency of treatment group were 46.9% and 84.7% separately, and the recurrence rate of which at the end of 12th week after treatment was 5.1%. There were significant differences compared with the control group(18.6%,54.3% and 18.6% respectively) (all P<0.01). Also, the side-effect was slight and could be tolerated by patients in the treatment group.Conclusion　The therapy of topical 0.1% tazarotene cream combined with local injection of triamcinolone acetonide in the treatment of prurigo nodularis has an excellent efficiency, and which should be commendably recommend in the treatment of such disease.]]> 2018/2/23 15:17:06 LI Yu-qiu， WEI Lan，HUANG Qi-tao，et al. 425true ［Abstract］　Objective　To use the principal component analysis and cluster analysis to study the early biochemical markers of pancreatitis，and classify the pancreatitis（AP） patients according to their characteristics.Methods　The data of analysis of blood cells and blood chemistry examination in 24 AP patients admitted in hospital from May 2011 to April 2012 was investigated，the principal component analysis was performed by SPSS13.0 software，cluster analysis by SPSS13.0 and SAS software.Results　According to the results of principal component analysis the early biochemical markers of AP can be classified into 4 categories，including related changes in enzymes,blood concentration and inflammatory exudation situation,coagulation and severity of infection. The cluster analysis results showed that for the majority of AP patients,its incidence had regularity，which could provide the basis and reference for standardized treatment.We should Pay particular attention to the patients with higher valves of lipase, amylase, aspartate aminotransferase, alanine aminotransferase values, hematocrit and obvious abnormalities of monocytes, then provide guidance for research of pathogenesis pancreatitis and the development of individualized treatment plan.Conclusion　The data can be fully explored by principal component analysis and cluster analysis, timely evaluate the state of the patients’ disease and to classify patients based on the results, and provide the basis and reference for early diagnosis, early treatment and prevention of complications.]]> 2018/3/12 9:42:55 WANG Zhi-min,WANG Gang,JI Jia-chao,et al. 424true ［Abstract］　Objective　To investigate the clinical value of ultrasound, CT scan, MRI/MRCP examination in the diagnosis and treatment of hilar cholangiocarcinoma.Methods　The cases of hilar cholangiocarcinoma,statistical analysis of ultrasound, CT scan,MRI/MRCP examination of the hilar cholangiocarcinoma in qualitative, positioning, type, vascular invasion and metastasis diagnosis was performed.Results　Accuracy rate of CT scan, MRI/MRCP examination was higher than ultrasound.Conclusion　The imaging examination has important clinical application value in the diagnosis and treatment of hilar cholangiocarcinoma.]]> 2018/3/12 9:42:55 DAI Lei,LU Qing-kai,DONG Gang, et al. 423true ［Abstract］　Objective　To study the effect of interdialytic weight gain rate(IDWG%),dry weight(DW),body mass index(BMI),ultrafiltration volume(UF) and intradialytic weight loss rate on hemodialysis adequacy(spKt/V).Methods　A retrospective analysis was performed on the records of 58 patients who received maintenance hemodialysis (MHD)for at last 6 months at Weifang People’s Hospital.The data were used to calculate IDWG%, DW, BMI, Intradialytic weight loss rate. And then, the correlation of spKt/V with BMI, UF, IDWG, IDWG%,DW, intradialytic weight loss rate were analyzed.Results　DW,BMI were negatively related to spKt/V(P<0.01). UF, IDWG was irrelevant to spKt/V(P>0.05). IDWG%, intradialytic weigh loss had a positive relationship with spKt/V(P<0.05).Conclusion　In order to improve quality of life, MHD patients should keep their BMI within the normal range and different patients should have different rules to control weight gain during MHD period.]]> 2018/3/12 9:42:55 ZHAO Jie, ZHAO Zhan-yun 422true ［Abstract］　Objective　To investigate the expression and significance of Bmi-1 in non-small cell lung carcinoma(NSCLC) tissue, and evaluate its relationship with the expression of p16.Methods　The quantities of Bmi-1 and p16 protein expression were detected by immunohistochemical assay in NSCLC and normal lung tissues.Results　Immunohistochemical studies showed that the positive rate of Bmi-1 in NSCLC tissues was significantly higher than that in normal lung tissues, and the expression of Bmi-1 significantly associated with TNM staging and lymph node metastasis. The expression of Bmi-1 was significant negatively associated with the expression of p16 in NSCLC tissues (r=-0.281, P<0.05).Conclusion　It has shown that Bmi-1 has important effect in the progression and metastasis of NSCLC.]]> 2018/3/12 9:42:55 ZHAO Jun-sheng, CHEN Xiao-yan 421true ［Abstract］　Objective　To observe the effects of acupuncture combined with movement therapy in treatment of scapulahumeral periarthritis.Methods　Sixty patients with scapulohumeral periarthritis were divided into 2 groups.Thirty patients in treatment group were treated by acupuncture combined with movement therapy, thirty patients in control group were treated by the medical gymnastics.The efficacy was summarized after 30 times treatment in the two groups.Results　The total effective rate of treatment group was 93.3%.The total effective rate of control group was 70.0%.It showed statistically significant difference between the two groups (P<0.05).Conclusion　The acupuncture combined with movement therapy has obvious effect in treatment of scapulohumeral periarthritis and thus improves patients’ ability of life.]]> 2018/3/12 9:42:55 LIU Shi-dan 420true ［Abstract］　Objective　To explore the relationship between nasopharyngeal carcinoma and mRNA of FHIT and MDR1 gene.Methods　Real-time PCR was used to test the two gene′s mRNA expression in 45 inflammatory control group and 61 nasopharyngeal carcinoma group.Results　The two gene′s mRNA expression was different between 45 inflammatory control group and 61 nasopharyngeal carcinoma group(P=0.049 and P=0.014 respectively). mRNA expression of FHIT was related to histological type, clinical stages and invasion stages. It was lower in the nasopharyngeal carcinoma than that inflammatory control group.It declined with the cancer deteriorating. mRNA expression of MDR1 is higher in the 61 nasopharyngeal carcinoma group. There were no correlation between the expression of FHIT mRNA and MDR1 mRNA in nasopharyngeal carcinoma tissue(P=0.14).Conclusion　The expression of FHIT mRNA is lower and MDR1 mRNA is higher in nasopharyngeal carcinoma tissue. There is no correlation between FHIT and MDR1.]]> 2018/3/12 9:43:40 LI Ping, MO Wu-ning, Chen Xu, et al. 419true ［Abstract］　Objective　To explore the feasibility of application of polycyclic mucosal resection in the treatment of intestinal lesions.Methods　The polycyclic mucosal resection was used for the treatment of intestinal flat lesions in 18 patients with flat lesions. Its removal rate and the probability of complications such bleeding,performation were observed.Results　The removal rate of polycyclic mucosal resection was 85.00%;bleeding rate was 11.76%.Conclusion　Polycyclic mucosal resection has advantages of less trauma, safe and reliable effect.]]> 2018/3/12 9:43:40 LUO Xian-ke, TAN Jian-rong,TANG Xue-yuan 418true ［Abstract］　Objective　To study the relationship between the serum level of LDH, β₂-MG and clinical diagnosis,stage and effectiveness of treatment in patients with non-Hodgkin lymphoma(NHL).Methods　The level of serum LDH and β₂-MG in 32 patients with NHL(NHL group) and 35 healthy subjects(control group)were detected respectively.Results　(1)The level of serum LDH and β₂-MG in NHL group were obviously higher than those in the control group（P<0.01）；(2)The level of serum LDH and β₂-MG in Ⅲ+Ⅳstage were obviously higher than that in Ⅰ+Ⅱ stage（P<0.01）；(3) After two cycles of chemotherapy,there was statistical difference between prechemotherapy and postchemotherapy (P<0.01).Conclusion　The levels of serum LDH and β₂-MG can be taked as an reference index for diagnosis, classification, effectiveness of treatment in the patients with NHL.]]> 2018/3/12 9:43:40 GU Ai-hu,KOU Ke-ren, WANG Yong,et al. 417true ［Abstract］　Objective　To explore the clinical value of MSCTA in venous occlusive diseases of lower extremity.Methods　The MSCTA data of 40 cases of venous occlusive diseases of lower extremity conformed by digital subtraction angiography (DSA) were reviewed. The findings of MSCTA were compared with that of DSA and the accuracy of MSCTA was analyzed.Results　There were 39 cases of venous occlusive diseases of lower extremity conformed by MSCTA,including 32 cases of venous thrombosis of the lower extremity and 12 cases of iliac vein compression syndrome.There were 5 cases of deep vein thrombosis.The results were accordant between DSA and MSCTA in the all cases.Conclusion　MSCTA is an effective examination in diagnosis of venous occlusive diseases of lower extremity.]]> 2018/3/12 9:43:40 ZHENG Yu- fei,WANG Zuo-qun,ZHU Li-li,et al. 416true ［Abstract］　Objective　To evaluate the diagnostic value of neuron-specific enolase(NSE) in malignant pleural effusion. We selected relevant literatures to undertake a meta analysis for evaluating the diagnostic value of NSE in malignant pleural effusion.Methods　The inclusion criteria to selected literatures was formulated. Required indicators were extracted from selected literatures and pooled by using random-effects models to determine sensitivity, specificity, and other measures of accuracy of NSE concentrations in the diagnosis of pleural effusion. Summary receiver operating characteristic curves were used to summarize overall test performance.Results　Ten studies met our inclusion criteria and were selected eventually. The summary estimates for NSE in the diagnosis of malignant pleural effusion in the studies included were as follows: sensitivity, 0.29(95%CI 0.25～0.33); specificity, 0.87(95%CI 0.84～0.89); positive likelihood ratio, 3.67(95%CI 2.06～6.54); negative likelihood ratio,0.77(95%CI 0.63～0.95); and diagnostic odds ratio, 5.24(95%CI 2.22～12.38).Conclusion　NSE determination is not a sensitive and specific test for the diagnosis of malignant pleural effusion. The measurement of NSE levels in pleural effusions is not a useful tool for differentiation between malignant and benign pleural effusion. NSE levels in pleural effusions should be interpreted in parallel with clinical manifestations and the results of conventional examinations.]]> 2018/3/21 8:06:39 LUO Ling, LIU Hang, LIANG Da-hua 415true ［Abstract］　Objective　To observe the clinical efficacy of infantile eczema treated by external washing of chinese medicine combined with Desonide cream and vitamin E allantoin cream.Methods　The patients were randomly divided into two groups. The treatment group(n=40) were treated by external washing of Chinese medicine combined with Desonide cream and vitamin E allantoin cream；the control group by Desonide cream.Results　The EASI scores in the treatment group was significantly lower than that in the control group(P<0.05).Compared with the EASI scores before treatment EASI scores declined significantly after treatment in two groups (P<0.01). The effective rate in treatment group was 85.00%, that in the control group was 52.50%, the difference was significant between two groups (P<0.01). The recurrence rate in the treatment group was 12.5%, that in the placebo group was 32.5%, after three months,there was a significant difference between two groups (P<0.05).Conclusion　External washing of Chinese medicine combined with Desonide cream and vitamin E allantoin cream in the treatment of infantile eczema has satisfactory curative effect and higher safety.]]> 2018/3/21 8:06:39 LI Juan，HUANG Zhi-xiong，LI Qing-hua 414true ［摘要］　目的　探讨聚丙烯酰胺凝胶对大鼠肝肾、皮下组织及背阔肌的毒性作用。方法　SD大鼠20只随机分成实验组和对照组各10只，在实验组SD大鼠背侧皮下注射25%聚丙烯酰胺10 ml，对照组SD大鼠背侧皮下注射生理盐水10 ml。1个月后分别取各组SD大鼠肝脏、肾脏、皮下组织和背阔肌组织，光镜下观察肝、肾和皮下组织病理学改变以及透射电镜观察各组肝、肾、背阔肌超微结构变化。结果　实验组光镜及电镜下肝、肾均出现较明显细胞变性，皮下组织肉眼及光镜下均未见明显病理学改变，电镜下背阔肌肌纤维变性。对照组肝、肾、皮下组织及背阔肌光镜及电镜下表现均为正常状态。结论　聚丙烯酰胺凝胶对SD大鼠的肝、肾及背阔肌组织均能产生细胞变性。]]> 2018/3/21 8:07:41 麦　慧，朱格非，张　驰，傅丽清，滕晓颦，樊秋晓 413true ［Abstract］　Objective　To investigate the clinical effects of intravenous drip of magnesium sulfate in the treatment of oligohydramnios.Methods　Sixty late pregnant women who diagnosed as oligohydramnios by ultrasound were randomized into therapy group (n=30) and control group (n=30). Patients of control group were treated with fructopyranose, energy mixture and amino acid liquid for 7 days. Patients of therapy group were given intravenous drip of magnesium sulfate except above therapy. Amniotic fluid indexes and fetal umbilical blood flow S/D ratio were compared by ultrasound before and after treatment in two groups.Results　Amniotic fluid indexes before and after treatment of therapy group was (6.67±0.75) and (10.46±1.33) respectively(P<0.01). Fetal umbilical blood flow S/D ratio was (2.97±0.29) and (2.44±0.39) before and after treatment (P<0.05). The therapentic effect of therapy group was better than control group.Conclusion　Intravenous drip of magnesium sulfate could obviously improve the therapeutic effect and pregnancy outcome in a certain degree in late pregnant women with oligohydramnios.]]> 2018/3/21 8:07:41 WU Hua，CHEN Chang-yi 412true ［Abstract］　Objective　To investigate the value of plasma pro B-type natriuretic peptide level in diagnosis of cirrhotic cardiomyopathy(CCM).Methods　Plasma proBNP levels,the changes on ECG(QTc,QTd,QTcd and Pd) were measured and evaluated in 38 patients with cirrhosis and 20 healthy controls, and compared between the two groups. In patients with cirrhosis, the association between the changes on ECG and CTP score,MELD score,proBNP levels were analyzed.Results　ProBNP was significantly higher in patients with cirrhosis(228.0±83.4)fmol/ml than in healthy controls(127.4±21.1 )fmol/ml. And in patients with cirrhosis,the changes on ECG, QTc、QTd,QTcd and Pd, were （446.9±28.0）ms^1/2,（36.4±6.6）ms,（40.6±9.0）ms^1/2,（22.8±4.8）ms respectively and significantly increased compared with healthy subjects（417.2±21.5）ms^1/2,（29.6±4.9）ms,（31.1±4.9）ms^1/2,（19.0±4.1）ms, and positively related to CTP score,MELD score and proBNP level.Conclusion　The plasma level of proBNP was valuable for diagnosis of CCM，and correlated with the severity of CCM.]]> 2018/1/24 8:18:04 CHEN Feng-song，XING Wei-song，WANG Song-liu，et al. 411true ［Abstract］　Objective　To investigate the clinical effects of kaishi injection combined with torasemide in the treatment of patients with hypertensive chronic renal failure.Methods　Sixty-six patients with hypertensive chronic renal failure were enrolled and randomly divided into observation group and control group,thirty-three cases for each group.Patients in the observation group were treated with kaishi injection combined with torasemide,the patients in the control group were treated with kaishi injection only.After fourteen days′ treatment, SCr, BUN and 24h urinary protein were measured.Results　After treatment the levels of SCr, BUN and 24h urinary protein decreased in two groups, but the reduction of above indexes in the research group was much lower than the control group（P<0.01）.Conclusion　Kaishi injection combined with torasemide has more positive effect in the treatment of hypertensive chronic renal failure than kaishi injection only.]]> 2018/1/24 8:18:04 HE Xian-guang,CHI Shao-Jie 410true ［Abstract］　Objective　To investigate the diagnostic value and influencing factors of the first transurethral resection of bladder tumor(TURBT).Methods　The clinical data was retrospectively analyzed on 112 cases of non-muscle invasive bladder cancer, pathological results of bladder cancer were determined by the first TURBT, and then the pathological results were compared between the first TURBT and the second transurethral resection(93 cases) or partial cystectomy(9 cases) or radical cystectomy(10 cases) after 2 to 6 weeks.Results　The tissue morphology changes were found in 23 patients and the absence of the detrusor muscle in 35 patients,relying on the specimens collected during the first TURBT.After first TURBT tumor residues were found in 47 patients, and the pathological results were identical in 84 patients and were under-staging in 28 patients by comparison. The risk of tumour progression,the tumor locations，the method of transurethral resection and the operator′s experience were apparently related to tumor residues after first TURBT(P<0.05).The degree of relevance was as follows,from more to less,by logistic regression analysis:the risk of tumour progression,the method of transurethral resection,the operator′s experience,the tumor locations.The method of transurethral resection and the operator′s experience were apparently related to the specimens lacked muscle tissue(P<0.05).The transurethral device were apparently related to tissue morphology changes.The specimens lacked muscle tissue and the tissue morphology changes were apparently related to pathological results from the first TURBT（P<0.05）.Conclusion　There are still shortcomings with the first TURBT,such as the high rate of tumor residue and pathological underestimate,the poor quality of specimens.A experienced urologist is advocated to adopt the diagnostic TURBT by bipolar plasmakinetic scalpel system.It is necessary for high-risk tumors to receive a second TURBT.]]> 2018/1/24 8:18:04 RONG Zu-yi, LIANG Jian-bo, LI Wei, et al. 409true ［Abstract］　Objective　To explore the imaging features of rhabdomyosarcoma in children.Methods　Clinical data and imaging findings of 19 children with rhabdomyosarcoma were retrospectively analyzed.Results　Two cases were located in head and face，2 in abdominal cavity，11 in pelvic cavity，2 in extremities, and 2 near to vertebral column.Seventeen cases were embryoid rhabdomyosarcoma, and 2 cases were alveolar rhabdomyosarcoma.The imaging findings included similar density or signal intensity to soft tissue,obvious enhancement,and lytic lesion of adjacent bone.Conclusion　The imaging features of rhabdomyosarcoma are the same as tumours of soft tissue and unspecific. We can make a correct diagnosis by combining the age of children with clinical features.]]> 2018/1/24 8:18:05 GAO Feng,TANG Wen-wei,LI Xiao-hui,et al. 408true ［Abstract］　Objective　To summarize the clinical application effect of immediate breast reconstruction using(extended) latissimus dorsi flaps after skin-sparing modified radical mastectomy for patients with breast cancer.Methods　A total of 5 patients with breast cancer undergoing immediate breast reconstruction using(extended) latissimus dorsi flaps after skin-sparing modified radical mastectomy from June 2010 to October 2012 were included in this study. The perioperative results were analyzed.Results　All 5 patients were successful with well recovery.Subcutaneous effusion occurred in 3 patients and were cured after local treatment.All patients were followed up for 6～34 months after operation, and local recurrence was not found.Conclusion　Immediate breast reconstruction using(extended) latissimus dorsi flaps after skin-sparing modified radical mastectomy for patients with breast cancer has the advantage of good breast appearance.]]> 2018/1/24 8:18:05 LI Qing-guo,CHEN Long-zhou,WANG Jin-xing 407true ［Abstract］　Objective　To explore the predisposing cause and the clinical manifestations of Penicilliosis marneffei(PSM).Methods　The clinical data of 64 patients with PSM was reviewed and analyzed.Results　The main predisposing cause of PSM was AIDS（accounted for 48.4%）.For non HIV positive patient,underlying diseases of lung was the main pathogenic predisposing cause(accounted for 68.3%).The other predisposition causes included: diabetes mellitus long, term use of glucocorticoids,long-term use of broad spectrum antibiotics, using antituberculosis drug,the history of close contact with Penicillium marneffei(PS).Conclusion　The patients with above past history or underlying diseases should be alerted to the possibility of the PSM.]]> 2018/1/24 8:18:34 LI Ping， MO Wu-ning， LI Shan， et al. 406true ［Abstract］　Objective　To explore the characteristics of the sleep monitoring in patients with narcolepsy and patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods　The sleep latency(SL)， sleep onset rapid eye movement period(SOREMP),total sleep times(TST),sleep efficiency(SE) and apnea hypopnea index(AHI) were determined in 15 patients with narcolepsy group and 15 patients with OSAHS group using multiple sleep latency test（MSLT) and all-night sleep recording by polysomnography(PSG) measurements, and the monitoring results were compared between two groups.Results　Compared to OSAHS group, narcolepsy group showed SL was shorter significantly［(3.93±2.99)min vs (10.39±2.01)min，P<0.01］ and SOREMP was increased significantly［(2.87±0.83) vs (0.27±0.59)times/h，P<0.01］ on MSLT. The sleep parameters of PSG showed that compared to OSAHS group,TST was less［(395.77±47.74)min vs (495.95±29.15)min，P<0.01］,and SE was lower［(75.95±4.37)% vs (82.81±2.81)%,P<0.01］in the narcolepsy group than those in the OSAHS group(P<0.01)；AHI was higher in OSAHS group than that in narcolepsy［(25.85±3.61) vs (0.79±1.08)times/h，P<0.01］.Conclusion　SL was shorter and SOREMP was more in narcolepsy group than those in OSAHS group.PSG showed that TST was less,and SE was lower in narcolepsy group than those in OSAHS group.The sleep respiratory disturbance is more obvious in the OSAHS group than that in narcolepsy group. The MSLT combined with PSG have played an important role in the diagnosis and differential diagnosis of narcolepsy and OSAHS.]]> 2018/1/24 8:18:34 LIANG Da-hua, LIU Jian-hong, XIE Yu-ping 405true ［Abstract］　Objective　To investigate the effects of surgical managements of acute obstruction caused by primary left colorectal carcinoma in the elderly.Methods　Clinical data of 103 patients with acute obstruction caused by primary left colorectal carcinoma, who were treated by emergent operation in the people′s hospital of Zhengzhou from January 2008～January 2012, were retrospectively analyzed.Results　Of 71 patients with left colon carcinoma, 26 received one stage tumor resection and anastomosis, 19 received Hartmann operation, 7 were performed colostomy and then tumor resection, and only 19 patients who had celiac metastasis received colostomy. Of 32 patients with rectal carcinoma received emergency operation, 5 received preoperative stent insertion and Dixon operation，16 received Hartmann operation, and only 11 patients with celiac metastasis were performed colostomy. As postoperative complications, incision infection occurred in 6 cases and intestinal fistula in 6 cases. Otherwise, 2 patients died for pneumonia.Conclusion　Dissolving those obstructions and saving patients′ life was the key for surgical treatment of acute obstruction caused by primary left colorectal carcinoma in the elderly. Surgical treatment should be considered as the first choice, and the selection of appropriate surgical methods should be dependent on the patients′ illnesses and regional medical conditions.]]> 2018/1/24 8:18:34 ZHANG Chun-li, WANG Hong-shan，LI Ying, et al. 404true ［Abstract］　Objective　To compare the result of white blood cells in the urine by the automated urine analyzer(dry chemical method), automatic urinary sediment analyzer and artificial microscopy.Methods　Three different methods(dry chemistry method ， urinary sediment method and artificial microscopy）were used for determination of white cells in 845 urine samples,and the results were compared.Results　Using the microscope detection results as the gold standard in 845 urine samples, the detection of dry chemical method for urine leukocyte showed the positive coincidence rate was 89.69%,the negative coincidence rate was 66.82%, the false positive rate was 33.12%, the false negative rate was 10.31%, the positive likelihood ratio was 2.71, the negative likelihood ratio was 0.15, the total coincidence rate was 72.07%, comparing the results of the two methods, the difference was statistically significant(P<0.01). The detection of urinary sediment method for urine leukocyte showed the positive coincidence rate was 95.87%, the negative coincidence rate 83.56%, the false positive rate is 16.44%, the false negative rate was 4.13%, the positive likelihood ratio was 5.80, the negative likelihood ratio was 0.05, the total coincidence rate 86.39%, comparing the results of the two methods, the difference was statistically significant(P<0.01).The comparison between the dry chemical method and urinary sediment method showed the positive coincidence rate was 89.41%, the negative coincidence rate 76.81%, the false positive rate is 23.19%, the false negative rate was 10.59%, the total coincidence rate was 81.18%, the positive likelihood ratio was 3.85,the negative likelihood ratio was 0.13, there was significant statistically differences between two methods(P<0.01).Conclusion　Urine visible components are complex, full automatic instrument method can not completely replace the microscopy and can only be used as a sieving mothod in analysis of large quantities of samples, so its positive test results still need to use the microscopy to improve accuracy in reporting results. The combination of the three kinds of methods can improve the accuracy of the detection results and have great value in clinical application.]]> 2018/1/24 8:18:34 LI Hang， MA Chun-yan， LI Xiang-lei，et al. 403true ［Abstract］　Objective　To summarize the experience of carotid endarterectomy in prevention and treatment of the ischemic stroke.Methods　From October 2001 to December 2011, 196 patients with unilateral internal carotid artery stenosis received carotid endarterectomy.In operation, carotid artery, shunts were applied in 47 cases, blocking blood flow in 149 cases. The preoperative carotid angiography showed internal carotid artery stenosis greater than 70% in 133 cases, more than 95% in 63 cases. There were 71 cases to be complicated by coronary artery lesions, 17 cases received coronary artery bypass simultaneously.Results　The postoperative clinical symptoms improved in 191 cases, cerebral hemorrhage appeared in 3 cases within 1 week after operation, among them after the hemostatic craniotomy drainage, 1 case was healed, 2 cases died. In 12 cases hematoma appealed inside cervical incision and were cured by the surgical debridement hemostasis. All cases were followed up for 6 to 60 months, 166 cases received follow-up, lost fellow-up in 28 cases, 38 cases died of disaster or ill in a follow-up. There were no attack of cerebral ischemic symptoms again in128 cases.Conclusion　Carotid endarterectomy is an effective and safe treatment for severe carotid artery stenosis.]]> 2018/1/29 9:14:33 WANG Min, TONG Xian-zhou,TONG Lin-long 402true ［Abstract］　Objective　To study the efficacy and safety of LASIK for myopia with presbyopia.Methods　LASIK was performed on 60 eyes of 30 myopia patients with presbyopia who had refraction from （-5.25±2.25）D.The value of cutting was decided by the different factors such as age, occupation, patients′ requirement and so on, referring to retractive status and ADD index, using commonly 1/2 to 2/3 of ADD value,on 1 day, 1 week, 1 month, 3 months, 6 months after operation, uncorrected vision, near visual and diopter, reading situation and reading comfort level were checked. Preoperative and postoperative changes were compared.Results　Most eyes got good uncorrected vision on the first day after operation,near vision had no obvious decrease, no obvious reading difficulties and visual fatigue occurred.Six months after surgery 60 eyes′ far visual acuity were 0.8～1.2.Conclusion　LASIK is an effective method for the correction of myopia with presbyopia, however, the operation technique and parameters remain to be further studied.]]> 2018/1/29 9:14:33 LONG Shu-guang 401true ［Abstract］　Objective　To study the causes of conversion to laparotomy during laparoscopic cholecystectomy(LC).Methods　A retrospective analysis was performed on the causes of conversion to laparotomy in 30 patients received LC.Results　The causes of conversion to laparotomy, included obscure anatomical relation in surgical site in 16 cases, accounted for 53.3%; anomolous anatomical in 6 cases, accounted for 20.0%; widely oozing blood of gallbladder bed in 4 cases, accounted for 13.3%; bleeding of cystic artery in 3 cases, accounted for 10.0%; injury of the extrahepatic bile duct in one case, accounted for 3.3%.Conclusion　Conversion to laparotomy should be timely performed when LC meeting difficulties, in order to get the best long-term curative effect. Preoperative careful evaluation, strictly laparoscopic surgical indications,and intraoperative careful accurate anatomical location, can reduce the rate of conversion to laparotomy.]]> 2018/1/29 9:14:33 HUANG Tao,ZHU Hong,LIU Jia, et al. 400true ［Abstract］　Objective　To explore the safety and efficacy of intracoronary injection of half dose of tirofiban for the slow flow in elderly patients with acute myocardial infarction during emergency percutaneous coronary intervention(PCI) operation.Methods　Ninety-eight elderly patients with myocardial infarction who had slow flow during emergency PCI operation were randomly divided into A group and B group, with 49 cases in each group, and were given 5 μg/kg and 10 μg/kg tirofiban in the coronary artery respectively. Between two groups the plasma C-reactive protein, serum creatine kinase MB and cardiac troponin I, cardiovascular events, bleeding with in 3 days after operation were compared.Results　Baseline and third day after operation, the two groups had no statistically significant difference in serum C- reactive protein, serum creatine kinase MB and cardiac troponin I(P>0.05). Two groups had no decrease in hemoglobin, hematocrit and platelet counts, no allergic reaction was found. 2 cases of mild bleeding in A group(4.08%), 3 case of mild bleeding in B group(6.12%), no significant difference between two groups(P>0.05).Conclusion　Intracoronary injection of half dose of tirofiban has the exact efficacy on slow flow of elderly myocardial infarctionin patients undergoing emergency PCI, and is safe and effective with less adverse reaction, and is worth of clinical application.]]> 2017/12/25 16:02:34 LIANG Kun 399true ［Abstract］　Objective　To evaluate the clinical effectiveness of painless ward program on management of perioperative pain for orthopedic surgeries.Methods　Between March 2013 and December 2013, 96 patients operated with orthopaedic surgeries were treated by perioperative analgesia(including pre-emptive analgesia, intraoperative cocktale local analgesia, postoperative analgesia). The Numeric Rating Scale(NRS) to measure the postoperative pain were used. The functional exercise,the quality of life and the stay days after operation were counted.Results　The maximun NRS was 4, and the minimun was 0(mean 0.76), while the postoperative stay days in hospital were between 9 and 1 days(mean 4.3 days). All patients can do some functional exercises after operation,and had a good postoperative quality of life.Conclusion　The perioperative analgesia management can reduce the postoperative pain, make patients having sooner recovery and shorten the stay days in hospital after surgery, it could be applied in clinical practice.]]> 2017/12/25 16:02:34 OU Yu-fu, LI Rong-zhu, WU Hao, et al. 398true ［Abstract］　Objective　To explore the synchronous chemoradiotherapy of clinical curative effect and adverse reaction of synchronous chemoradiation therapy in the treatment local medium-term and advanced cervical cancer.Methods　According to random number table method，one hundred and twenty patients withⅡb-Ⅳa cervical cancer receiving initial treatment were divide into synchronous chemotherapy group(60 cases) and simple radiotherapy group(60 cases).Results　Between two groups there were statistically significant difference in short-term therapeutic effect，5-years′ survival rate，local recurrence rate and distant metastasis rate in 5-year(P<0.05)；and there were statistically significant difference in gastrointestinal reaction,bone marrow suppression(P<0.05)；no significant difference were observed in the radiation proctitis and radioactive,cystitis(P>0.05).Conclusion　Synchronous chemoradiotherapy can improve short-term therapeutic effect of local medium-term advanced cervical cancer, improve the 5- year survival rate, reduce local recurrence rate and distant metastasis rate in 5-years,but significantly increase the gastrointestinal reaction and bone marrow suppression.]]> 2017/12/25 16:02:34 GAN Zu-huan, GAN Lang-ge 397true ［Abstract］　Objective　To prepare PLA-Rifapentinum microspheres(RifapM) for lung targeting and evaluate it′s rule of rifapentinum release and lung targeting in mice.Methods　Solvent volatilization was used to prepare lung targeting RifapM，and dynamic dialysis method was adopted to observe the rule of rifapentinum release.In vivo distribution was studied.Results　The diameters of 81.6% microspheres were between 7～30 μm，the average diameter was (14.2±3.1)μm. Entrapment efficiency was 78.39%.The drug supporter in microspheres was (39.6±3.6)%(n=5).The invitro release T₅₀ was 68 min, and was 4.5 times more than that of the control group.The relative distribution percentage of RifapM in lung after iv administration to mice was significantly higher than those in other tissues and blood，and was 3.3 times more than control group.Conclusion　RifapM have evident sustained-release and lung targeting.]]> 2018/1/2 8:38:52 FAN Ying, GUO Mei-hong, LIANG Kai, et al. 396true ［Abstract］　Objective　To explore the efficacy of pramipexole in the treatment of advanced Parkinson′s disease（PD）.Methods　Thirty-two PD patients with Hoehn-Yahr Ⅳ～Ⅴ has been treated with levodopa more than 2～6 years as the research object. Pramipexole was added, and evaluated the curative effect after 12 weeks. Motor symptoms: PD rating scale(UPDRS) was used to evaluate treatment effect;Non-motor symptoms: the changes were observed of the anxiety, depression, sleep disorder symptoms, and adverse reactions of patients were recorded.Results　The UPDRS scores of PD patients significantly decreased after treatment, and the difference was statistically significant（P<0.01）.All the patients has not suffered from serious adverse reactions in the process of treatment.Conclusion　For advanced PD patients adding pramipexole treatment on the basis of levodopa can effectively alleviate the motor symptoms and non-motor symptoms, obviously improve the quality of life at the same time.]]> 2018/1/2 8:38:52 WEI Chun-ying,HAN min,MO Ying-min,et al. 395true ［Abstract］　Objective　To evaluate the effect of tamoxifen(TAM) on endometrium in postoperative breast cancer patients treated with TAM.Methods　Edometrial biopsies were performed in 80 patients having abnormal vaginal bleeding or abnormal thickness of endometrial by ultrasound in TAM group.TAM group was divided into premenopausal and menopausal group or two groups including T<2 years and T≥2 years according to the time with tamoxifen.Results　The frequency of endometrial hyperplasia and polyps was higher in TAM group.All the atypical hyperplasia and endometrioid carcinoma cases occurred in menopausal group.The occurrence of endometrial disease had no relations with the duration of taking TAM.Conclusion　Risk of endometrial disease in postoperative breast cancer patients treated with TAM will be increased.More attention should be paid to the patients who were treated with TAM for breast cancer，and endometrium should be evaluated by pelvic ultrasound before and during TAM usage.]]> 2018/1/2 8:38:52 WANG Ya-li，CHEN Long-zhou，LI Qing-guo 394true ［Abstract］　Objective　To investigate the value of 64 slice spiral CT urography(CTU) in the diagnosis of urinary system congenital malformation.Methods　Thirty-four patients who had urinary system congenital malformation which were confirmed by cystoscope and operation were examined with CTU, combined with the staging scan, the statistical analysis of the urinary system malformations were completed.Results　Of the 34 patients, renal agenesis was found in 2 cases, renal dysplasia in 6 cases, renal fusion malformation(horseshoe kidney) in 4 cases; duplication of renal pelvis and ureter in 7 cases, congenital ureteral stenosis in 8 cases, abnormal ureteral orifice in 4 cases; bladder diverticulum in 2 cases; congenital bladder fistula of rectum in 1 cases; compared with the results of operation, the diagnosis rate was 100%.Conclusion　CTU for the diagnosis and classification of urinary system congenital malformation is of great clinical significance, and provides a guidance for clinical operation.]]> 2018/1/2 8:38:52 MO Shao-wu,CHEN Song,HUANG Ze-he,et al. 393true ［Abstract］　Objective　To investigate the ideal surgical procedures in treatment of circumferential mixed hemorrhoids.Methods　Anal plastic surgery with restrictive surgical nature was used to treat 102 circumferential mixed hemorrhoid patients, and the overall efficacy in patient was evaluated.Results　The average blood loss was 60 ml; operative average time was 65 min; postoperative pain grading showed grade Ⅰ pain in 34 cases, grade Ⅱ pain in 62 cases, grade Ⅲ pain in 6 cases; there were no incontinence and wound infections found, the cure rate was 100.0%; average length of stay was 9.11 d; after surgery 83 patients(269 case times) were followed up for 6 to 18 months. No anal stenosis, rectal mucosa eversion, and recurrence of mixed hemorrhoid were found, and the anus showed a smooth appearance.Conclusion　The procedure is in line with the principles of modern treatment of hemorrhoids, has advantage of simple surgical procedure,exact effect, etc, and is worthy of promotion.]]> 2018/1/2 8:39:31 FAN Xian-wei，WANG Si-jie,LUO Hai-hui, et al. 392true ［Abstract］　Objective　To evaluate the efficacy and safety of cytoreductive surgery(CRS) combined with hyperthermic intraperitoneal chemotherapy(HIPEC) in treating patients with peritoneal carcinomatosis(PC) from colorectal cancer(CRC).Methods　A total of 67 CRC PC were divided into two group: therapeutics group(n=38, CRS+HIPEC) and control group(n=29, CRS and systemic adjuvant chemotherapy).Overall median survival,survival rate, adverse reaction were compared.Results　Therapeutic group had a significantly better overall median survival when compared to control group(23.0 months vs. 11.0 months)（P<0.01). The 1-, 2- and 3- year survival rate of therapeutic group were 70.9%,45.7% and 8.2%, respectively, superior to those of control group(68.8%,21.2% and 0%).Two group had a similar postoperative complication rate(P>0.05). Chemotherapy toxic effects:control group had higher incidence rate in nausea and vomiting, leucopenia, thrombocytopenia(P<0.01) while therapeutic group higher in abdominal distension and diarrhea(P<0.01 or P<0.05). Two group had similar incidence rate in hypoproteinemia, hepatic and renal insufficiency, respiratory tract infections, hyperbilirubinemia(P>0.05).Conclusion　The CRS+HIPEC method can greatly improve the survival of patients with PC from CRC while doesn′t significantly increase postoperative complication rate and chemotherapy toxic effects.]]> 2018/1/2 8:39:31 WEI Shi-zhuang,LIU Jin-xin,FENG Guan-rong,et al. 391true ［Abstract］　Objective　To investigate the MRI features of lymphoepithelioma-like carcinoma(LELC) of the parotid gland in order to improve its recognition.Methods　The MRI features of 8 cases with LELC of parotid gland proved by pathology were analyzed.Results　All cases were solid masses on the left side of parotid gland, single in 3 cases, multiple in 5 cases. Four cases were situated in superficial lobe and deep lobe of the parotid gland, and 3 cases were situated in superficial lobe, and 1 case was situated between superficial lobe and deep lobe. T1-weighted imaging showed 4 cases with isointense or slight hyperintense signals, 4 cases with isointense; T2-weighted imaging demonstrated hyperintense in 6 cases, slight hyperintense in 2 cases. All lesions showed obvious enhancement in the early phase of MRI. There were 4 cases with complete or incomplete capsule, 2 cases with the incomplete partition, 2 cases with complete capsule. The capsules demonstrated hypointense signal on T1-weighted imaging and isointense signal on T2-weighted imaging, which demonstrated delayed enhancement. In 8 cases MRI displayed almost clear borders in 2 cases, clear borders in 3 cases, unclear borders in 2 cases. MRI displayed the subcutaneous fat and skin were involved in 6 cases, and not involved in 2 cases. Regional lymph node metastases were found in 6 cases, were not found in 2 cases.Conclusion　LELC of parotid gland exhibits some imaging features on MRI, which can be the clue for the diagnosis.]]> 2018/1/2 8:39:31 ZHOU Xiao-yan, MA Long-bai, HAN Wu, et al. 390true ［Abstract］　Objective　To investigate the clinical feature,treatment and prognosis of hypoglycemic encephalopathy in order to improve the levels of the cognition，the diagnosis and treatment of hypoglycemic encephalopathy and avoid the misdiagnosis.Methods　Clinical data of 28 cases of hypoglycemia encephalopathy were retrospectively analyzed.The clinical manifestation of mental and nervous symptom,treatment and prognosis in that were summarized and analyzed.Results　In the 28 patients，24 patients with hypoglycemic encephalopathy recovered well after active treatments,did not leave any sequela,2 patients left mild mental disorders,one patient left mental symptoms,one of them was confirmed for insulinoma by further examination,and was transferred to the superior hospital for further treatment.Conclusion　It is very important to improve the diagnosis and treatment level of hypoglycemic encephalopathy for clinical doctor. Taking detailed history and timely checking and controlling blood glucose will reduce the occurrence of hypoglycemic encephalopathy and it can be controlled well once happened.]]> 2018/1/2 9:44:23 LIU Ji-gang 389true ［Abstract］　Objective　To observe the clinical efficacy of marvelon combined with mifepristone in treating incomplete abortion of early pregnancy.Methods　Sixty patients with incomplete abortion and little decidual residue，the maximum diameter of which <20 mm measured by B ultrasonic examination，were randomly divided into 2 groups from July 2012 to July 2013. Patients in experimental group were treated with marvelon 2 pills qd for 7 days. From the 8^th day mifepristone was taken 75 mg qd for 3 days. Patients in control group were treated with routine uterine curettage.Results　The time of vaginal bleeding, the time of urine pregnancy test turning negative and the cure rate were not significantly different between the two groups(P>0.05). Two cases of pelvic inflammatory disease and no case of intrauterine or cervical adhesion were found in experimental group. Eight cases of pelvic inflammatory disease and 6 cases of intrauterine or cervical adhesion were found in control group. The above differences were significant(P<0.05).Conclusion　Combined application of marvelon with mifepristone is effective in treatment of patients with little decidual residue due to incomplete abortion，which avoid uterine curettage and decrease operative complications.]]> 2018/1/2 9:44:23 YU Lin，SU Ling-chun 388true ［Abstract］　Objective　To discuss the clinical application value of intensive insulin therapy(IIT) in severe traumatic brain injury(sTBI).Methods　Two hundred patients with sTBI(GCS 3～8) were randomly divided into the intensive insulin therapy group(IIT,n=100 cases)and the conventional insulin treatment group(CIT,n=100 cases). IIT group′s blood glucose(BG) was controlled in 3.9～6.1 mmol/L, CIT group′s blood glucose was controlled in 8.3～10.1 mmol/L. The patients after admission were treated using continuous intravenous infusion of insulin to control blood glucose.The average blood glucose levels, insulin dosage, incidence of hypoglycemia in two groups were recorded. Six months after injury, the efficacy was evaluated according to GOS valuation method including 5 grades: good, moderate disability, severe disability, vegetative state, and death.Results　During treatment BG in IIT group was lower than that in CIT group(P<0.01), the incidence of hypoglycemia,average hourly insulin dosage in IIT group were higher than those in CIT group(P<0.05 or P<0.01). After 6 months there were no statistically significant difference between the two groups in the efficacy including good, moderate disability, severe disability, vegetative state, and death(P>0.05).Conclusion　IIT does not improve the prognosis of patients with sTBI, but increase the incidence of hypoglycemia, blood glucose is controlled in 8.3～10.1 mmol / L is ideal.]]> 2018/1/2 9:44:48 HUANG Peng，HUANG Zhai, QIN Wen-bo,et al. 387true ［Abstract］　Objective　To observe the effects of artificial dermis combined with autologous thin layer skin grafts(composite skin) in repairing the refractory wounds.Methods　Thirty patients with refractory wounds were involved who had deep skin soft tissue defect, some cases complicated with exposure of muscles, tendons, bone. All of refractory wounds were repaired by the technology of combining artificial dermis with autologous thin skin transplantation. The technology included 2 steps: firstly, artificial dermis were transplanted on all refractory wounds after the debridement, then autologous thin layer skin were transplanted on artificial dermis 2～3 weeks after debridement, at that time the dermal tissue growing well and covering exposed tendon, bone tissue. Then the survival rate of artificial dermis and composite skin, the degree of scar hyperplasia, pigmentation change and joint activity were observed to evaluate the effects of composite skin repairing refractory wounds.Results　In 25 of 30 patients artificial dermis were survival after transplantation,the survival rate was 83.3%(25/30), the causes of 5 cases failure included local infection 4 cases and instability separately 1 case. The survival rate of composite skin was 100.0%(25/25). The composite skin showed smooth and flexible, no obvious change of scar hyperplasia and pigment on the area of composite skin and doner skin during of follow-up 2～6 months after discharge.Conclusion　The advantages of composite skin grafting were included high survival rate and well texture, no significant change of scar hyperplasia and pigment on the area of composite skin and doner skin, easily operation.]]> 2018/1/2 9:44:48 YANG Hua-lian, LIU Pan, DING Hua-rong, et al. 386true ［Abstract］　Objective　To summarize the experience of combination of laparoscope, choledochoscope, duodenoscope(three endoscopic combination) and choledochotomy with primary suture in the treatment of choledocholithiasis.Methods　Three endoscopic combination and choledochotomy with primary suture were used in 62 patients with choledocholithiasis.Results　Stones in 62 patients were successfully removed.At the first day and the third day after operation, the reexamination of liver function and blood, urine amylase showed postoperative alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL) in patients with abnormal liver function before operation significantly decreased, no raising blood and urine amylase was found. In one case, postoperative peritoneal drainage showed yellow bile for 3 days. All patients were followed up, the follow-up time were 3～6 months. At 2～8 weeks after operation review of MRCP showed no clear residual stone shadow was found in 62 patients, 5 cases were reported papillary stenosis shadow, but no symptoms and signs, and were not treated. At 3～6 months after operation review of B-type ultrasound showed three cases were reported having bile duct gas accumulation and were not treated.Conclusion　The three endoscopic combination and choledochotomy with primary suture in the treatment of choledocholithiasis is safe, effective and feasible, and for appropriate cases, it is worthy of promotion.]]> 2018/1/2 9:44:48 ZHANG Yuan-wei, HUANG Xiong, CHEN An-ping, et al. 385true ［Abstract］　Objective　To study the role of parameters of pulmonary ventilation function in assessing asthmatic status and instructing treatment by measuring parameter of pulmonary ventilation function in children with asthma in acute exacerbation and remission.Methods　Forty three(5 to 12 years old) children with asthma both in acute exacerbation and in remission after treatment were studied. Pulmonary ventilation function parameters including large-airway pulmonary function values（FVC, FEV1, FEV1/FVC, PEF） and small-airway pulmonary function measurements（FEF25, FEF50, FEF75, MMEF75/25） in all subjects were measured in stage of asthma attack and in remission after treatment respectively by using Jaeger Master Screen diffusion determinator. Also the date of medical history and treatment of asthmatic children was collected at the same time.Results　There were statistically significant that pulmonary ventilation function parameters FVC, FEV1, FEV1/FVC, PEF of asthmatic children in acute exacerbation were decreased as compared to that of those in remission and healthy children group(P<0.01）; while pulmonary ventilation function parameters including FVC, FEV1, PEF in remission children after therapy with asthma were normal comparing to those of healthy children group(P>0.05）.The small airway function parameters FEF25, FEF50, FEF75, MMEF75/25 in children with acute asthma were obviously decreased, which be significantly different from that of those in remission and healthy children(P<0.01）; the parameters of FEF25, FEF50, FEF75, MMEF75/25 in asthmatic children of catabasis were lower significantly than that of those in healthy children(P<0.05）. The lower each index of pulmonary ventilation function parameters(FVC%pred, FEV1%pred, PEF%pred, FEF25%pred, FEF50%pred, FEF75%pred, MMEF75/25%pred) and the more severe in episode in asthmatic children, there were significant difference(P<0.05).Conclusion　There was likely to that the parameters of pulmonary ventilation function in asthmatic children of acute exacerbation were impaired. The parameters of small airway function were still decreased in asthmatic children in remission after therapy, while that small-airway pulmonary ventilation function parameters were more importance in assessing the state of asthma which could instruct treatment for asthma in children.]]> 2018/1/8 8:50:20 CHEN Hong-ling, XIE Qing-ling, HE Hai-lan, et al. 384true ［Abstract］　Objective　To analyze the maligant peripheral nerve sheath tumors(MPNST)′ MSCT, MRI imaging and pathological features in order to improve its diagnostic accuracy.Methods　The retrospective analysis of 17 cases of MPNST confirmed by operation and pathology were performed.Results　There were 4 cases in the upper limb, 4 cases in the lower extremity, 3 cases in the neck and back, 3 cases in the sacroiliac joint area, 2 cases in intraspinal area, 1 case in the esophagus. The huge tumor usually showed necrosis and haemorrhage but rare calcification. MSCT scan was mainly manifested as mixed hypodensity and isodensity irregular huge mass shadow, T₁WI mainly showed iso-/slight hypo-intensities, T₂WI and STIR mostly showed mixed hyper-/hypo-intensities. Contrast enhanced scan showed obvious ringlike enhancement about the edge of tumor and displayed nodous or patchy funicular heterogeneous enhancement of solid component within tumor. Pathology: the tumor had pseudocapsule and mainly showed the ball or spindle form. It showed more haemorrhage necrosis than cystic change and infrequent calcification. The tumor cell showed the varied forms and mainly was the spindle cell. The sensitive makers of the tumor were NSE, S-100, CD56, Vimentin, which showed more positive.Conclusion　MPNST often occur in the thick neural stem′s walk line area，there is a strong correlation between the manifestations of MSCT and MRI and the pathological features, The combination of the theirs is helpful in improving the level of diagnosis and differential diagnosis.]]> 2018/1/8 8:50:20 SUN Pei-yi, WANG Zheng, WEI Xiao-mei 383true ［Abstract］　Objective　To evaluate the clinical significance on detection of myocardial enzymes,high sensitivity C-reactive protein(hs-CRP)and peripheral white blood cells(WBC) count in children with hand-foot-mouth disease(HFMD).Methods　Thirty-eight children with severe HFMD who treated in our hospital from June 2012 to April 2013 were selected, and 138 children with mild HFMD were selected randomly, and 30 healthy children were used as control group. Serum myocardial enzymes,hs-CRP and WBC count were tested and the data were analyzed statistically.Results　The levels of serum myocardial enzymes，hs-CRP and WBC in the severe group were significantly higher than those in the control group and mild group(P<0.05).The levels of serum CK，CK-MB，hs-CRP and peripheral WBC in the mild group were significantly higher than those in the control group(P<0.05).Conclusion　The combined detection of myocardial enzymes,hs-CRP and WBC count could have higher value for early diagnosis and assessment of disease condition in the children with HFMD.]]> 2018/1/8 8:50:20 YU Guo-qing, ZHU Xue-long 382true ［Abstract］　Objective　To investigate the effect of the beraprost sodium on serum cystatin C, urinary microalbumin excretion rate and vascular endothelial function in patients with early diabetic nephropathy.Methods　Fifty-eight patients with early diabetic nephropathy were selected and randomly divided into 2 groups(control group with 30 cases and treatment group with 28 cases). Control group was treated with insulin,low-protein diet,control blood pressure; the treatment group was treated with beraprost sodium 40 μg tid on the basis of normal treatment for 12 weeks.The endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound，and the levels of endothelin-1(ET-1), Glycated hemoglobin(HbA1c), triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), 24 h urinary albumin excretion rate(UAER), serum cystatin C(Cys-C), endogenous creatinine clearance(Ccr) were measured respectively before and after treatment.Results　There was no statistically significant difference of blood sugar,blood pressure,blood lipid before and after treatment(P>0.05).After treatment，the levels of UAER, Cys-c and ET-1 in treatment group were significantly lower than those of the control group(P<0.05)，the levels of Ccr and FMD in treatment group were increased more significantly than control group(P<0.05).Conclusion　The beraprost sodium can effectively reduce the levels of UAER, Cys-C and recovery renal vascular endothelial function in the patients with early diabetic nephropathy.]]> 2018/1/8 8:50:20 LU Wei-bo，LI Shu-min，LV Yi-pei，et al. 381true ［Abstract］　Objective　To investigate the influence of the duration of hyperglycemia on cellular immune funtion in diabetic rat.Methods　Animal model of diabetes mellitus was establish via continuously intraperitoneal injection of streptozotocin.Twenty rats with successful modeling were randomly divided into 4 groups,each group include five rats.Group A:on the 4th day of successful modeling,insulin was injected to control glucose between 8～12 mmol/L. Group B: After 8 d of successful modeling，insulin was injected to control glucose. Group C: After 2 weeks of successful modeling，insulin was injected to control glucose. Group D: After successful modeling, blood glucose did not controlled in entire experiment course. 5 normal rats were used as control group at the same time. Peripheral blood cells were collected at 5 d, 8 d, 15 d and 4 weeks. The ratio of the CD4⁺, CD8⁺, CD4⁺/CD8⁺,CD4⁺CD25⁺/CD4⁺ T cells were detected by FCM.Results　(1)It showed no significant change of the ratio of CD4⁺, CD8⁺, CD4⁺/CD8⁺, CD4⁺CD25⁺/CD4⁺ T cells on 4 d, 8 d, 15 d and 4 weeks in group A and group B when compared with the control group. (2)In group C,there was a significant decrease of CD4⁺ T lymphocytes on 15 d,and the proportion of CD8⁺ T cell increased instead. The ratio of CD4⁺/CD8⁺ had a significant decrease(P<0.05). The ratio of the CD4⁺ T cells had significant increased between 15 d and 4 weeks after controlling glucose, but it was still obviously lower than that of control group(P<0.05). (3)In group D,there was a significant decrease of CD4⁺ T lymphocytes on 15 d,and the proportion of CD8⁺ T cell increased. The ratio of CD4⁺/CD8⁺ also had a significant decrease（P<0.05）. (4)The ratio of CD4⁺ CD25⁺ /CD4⁺ T cells hadn′t a significant difference between experimental groups and control group(P>0.05).Conclusion　Diabetic rats have cellular immune dysfunction mediated by hyperglycemia with duration time more than two weeks. It means that chronic hyperglycemia have great effect on cellular immune function.]]> 2018/1/8 8:50:54 YU Jin-ming,CAI De-hong,ZHANG Hua, et al. 380true ［Abstract］　Objective　To analyse the characteristics and treatment for perioperative complications of posterior lumbar fusion surgery.Methods　From January 2010 to December 2012, 473 patients underwent posterior lumbar fusion surgery in our hospital, and the characteristics and treatment of perioperative complications were analysed retrospectively.Results　Of 473 patients, 60 complications during the perioperative period occurred in 56 cases（accounted for 12.68%）, including nerve root irritation(16 cases), incision infection(10 cases), cerebrospinal fluid leakages(8 cases), urinary system diseases(7 cases), digestive system diseases(6 cases), hematologic system diseases(5 cases), cardiopulmonary system diseases(8 cases). And the complications were improved after symptomatic treatment.Conclusion　Perioperative complications of posterior lumbar fusion surgery may seriously affect the clinical result of the surgery and patients′ satisfactions. So besides the surgical indications and skilled technique, the targeted prevention during the perioperative period in advance is more advantageous to reduce the occurrence of complications.]]> 2018/1/8 8:50:54 LI Hua, LI Rong-zhu,WEI Jian-xun, et al. 379true ［Abstract］　Objective　To investigate the efficiency and safety of oral ibuprofen in the treatment of premature infant with neonatal respiratory distress syndrome(NRDS) combined with patent ductus arterious(PDA).Methods　Thirty-eight cases were included. The birth weight was between 920 g and 2 900 g, gestation age was between 26.57 weeks and 63.29 weeks. Ibuprofen suspension was given with dosage 10 mg/kg for 3 times. The heart rate, SaO₂, blood pressure, blood glucose, urine output, bilirubin and electrolyte were monitored during the treatment. The renal function, CBC, bilirubin and echocardiogram were examined before and after the treatment.Results　PDA was closed in 32 cases(84.21%). CBC, bilirubin, urine output, and serum creatinine did not show significant changes. The changes of CBC, bilirubin, urine output, renal function was not related with neither birth age, birth weight, days of breath support, method of breath support, day of drug given nor whether the application of pulmonary surfactant.Conclusion　Oral ibuprofen is effective and safety in closing PDA in premature infant with NRDS.]]> 2018/1/15 8:41:55 YANG Han-hua, HUANG Yue-jun, WU Ruo-qi, et al. 378true ［Abstract］　Objective　To observe the efficacy of cord blood cytokine- induced killer cells combined with gemcitabine and cisplatin in the treatment of advanced non-small cell lung cancer, and to study patients′ quality of life，to analyze the clinical value.Methods　Fifty-two patients with advanced non-small cell lung cancer were randomly divided into two groups. There were 25 patients in the observation group, 27 patients in the control group. The observation group were treated by GP plus CIK cell immunotherapy program and the control group of 27 patients were treated by GP program. Efficacy and adverse reactions were evaluated. QLQ-LC13 scale was used before and after treatment to assess the quality of life.Results　The observation group showed PR in 6 cases, SD in 10 cases, PD in 9 cases, the control group showed PR in 3 cases, SD in 7 cases, PD in 17 cases. The difference between the two groups was statistically significant(P<0.05). After treatment, the life quality scores in the observation group was better than that in the control group(P<0.05). The adverse reaction in the observation group was lower than the control group(P<0.05). In the observed group, the probability of fever was higher than that of the control group(P<0.05).Conclusion　The treatment of cord blood cytokine -induced killer cells combined with gemcitabine and cisplatin for advanced non-small cell lung cancer patients is safe and effective.It can improve quality of life of the patients with advanced non-small cell lung cancer.The treatment will be worth popularizing in clinical applications.]]> 2018/1/15 8:41:55 LANG Bo, YANG Xiu-zhi 377true ［Abstract］　Objective　To investigate the effect of periodontal therapy on the level of plasma glucose in type 2 diabetic patients with periodontitis.Methods　Sixty-two type 2 diabetic patients with periodontitis were randomly divided into two groups with 31 cases in each group. Periodontal therapy group received the therapy for periodontitis and diabetes and non-therapy group received only therapy for diabetes. The PD，AL，FPG and HbA1c of two groups were recorded before and after treatment for three months.Results　After treatment, periodontal therapy group had a statistical significance in the reduction of levels of PD，AL，FPG and HbA1c(P<0.01), but non-therapy group was not statistically significant in the changes of above indexes.Conclusion　The periodontal therapy has excellent therapeutic effect for type 2 diabetic patients with periodontitis.]]> 2018/1/15 8:41:55 FU Fei-huan，ZHANG Ze-jian,CHEN Qi-dong,et al. 376true ［Abstract］　Objective　To explore the suitable treatment plan of cesarean scar pregnancy(CSP).Methods　Clinical features of 17 patients of CSP patients in our hospital were retrospectively analyzed.Results　There were 17 patients with postmenopausal history, 10 patients with postmenopausal vaginal bleeding history, 3 patients received artificial abortion before diagnosis,2 patients received drug abortion,these 5 patients received hospitalization treatment because of postoperative vaginal bleeding, 5 patients were diagnosed.All of the 17 cases were cured,the average duration of hospitalization was （5.6±1.1）d.Conclusion　CSP is easy to misdiagnosis in clinic, for patients with cesarean section operation history,it should be necessary to combine the symptoms with signs and auxiliary examination to make an early diagnosis, and treatment plan according to the actual situation of different patients.]]> 2018/1/15 8:41:55 LING Dan，ZHAO Ren-feng 375true ［Abstract］　Objective　To investigate the relationship among neutrophils(NEUT), lymphocyte count(LY), radiation-induced oral mucositis and tumor regression rate in patients with nasopharyngeal carcinoma, as well as the dynamic changes before and after treatment.Methods　Sixty-eight patients with nasopharyngeal carcinoma first diagnosed as experimental group, serum samples were collected at admission, two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks after radiotherapy, the end of radiotherapy, 3 months after radiotherapy. Automatic blood cell analyzer was used to detect leukocytes(WBC), NEUT and neutrophil proportion(NEUTR), LY and lymphocyte proportion(LYR), proportion of neutrophils and lymphocytes(NLR), and 40 healthy people were enrolled in control group.Results　WBC, NEUT, NEUTR, LY, LYR and NLR did not show significant difference between NPC patients and healthy people(all P>0.05). NEUTR and NLR after treatment were significantly higher than before treatment(all P<0.01); WBC, LY, LYR after treatment were decreased significantly(all P<0.01). NEUTR was correlated with the degree of oral mucositis during the same period at 3,4,5,6,7 weeks, the end of radiotherapy and 3 months after radiotherapy(all P<0.05). The changes in LYR was correlated with tumor regression rate(P=0.048). The degree of oral mucosal injury was correlated with tumor regression rate at the end of radiotherapy(P=0.012).Conclusion　Monitoring the proportion of neutrophils can help judge the degree of radiation-induced oral mucosal injury during treatment. Periodic evaluation of radiation-induced oral mucosal injury during the treatment could help to predict short-term effect of NPC.]]> 2018/1/15 8:42:20 WENG Jing-jin, SI Yong-feng, QIN Yang-da, et al. 374true ［Abstract］　Objective　To summarize the experience of surgical treatment of incarcerated umbillical hernia in the patients with cirrhotic ascites.Methods　Clinical data of 17 patients with cirrhotic ascites,who had undergone incarcerated umbillical hernia and received emergent operation in the people′s hospital of Zhengzhou from July 2007～July 2012, were retrospectively analyzed.Results　Of 17 patients received operation, 15 received the release of incarcerated umbilical hernia and tension-free herniorrhaphy, and 2 received umbilical hernia repair and partial enterectomy. All 17 patients recovered without incision infection.Conclusion　Incarcerated umbillical hernias in patients with cirrhosis ascites should be treated as early as possible with correct operative methods. According to the severity of the disease, tension-free herniorrhaphy or hernia repair could be applied in the emergency repair of incarcerated umbillical hernia in patients with cirrhotic ascites.In the perioperative peroid,the rational integrated therapy should be performed.]]> 2018/1/15 8:42:20 ZHANG Chun-li,XU Hui，LI Ying，et al. 373true ［Abstract］　Objective　To explore the feasibility of thoracic drainage by using a single fine F-28 style chest tube inserted from the 7th intercostal at axillary line to the chest top after the lobectomy and lymph node dissection of lung cancer.Methods　The drainage volume, the time with the chest tube and the tolerance to it were observed in 55 patients after the lobectomy and lymph node dissection of lung cancer.Results　In 55 patients, there was no extension of the time with the chest tube and the tolerance to the chest tube was better.There was neither patient who need pethidine injection when chest pain localized and nor patient who need again puncturing for pleural drainage.Conclusion　The method of thoracic drainage by using one single fine F-28 style chest tube inserted from the 7th intercostal at axillary line to the chest top is a safe, reliable technique with less damage to patients after radical surgery of lung cancer.]]> 2018/1/15 8:42:20 SONG Xuan-tong 372true ［Abstract］　Objective　To evaluate the prognostic value of serum uric acid(SUA) in patients with dilated cardiomyopathy(DCM) complicated by heart failure（HF）.Methods　Seventy-eight patients hopitalitalized with DCM were included in this study. SUA were measured on admission. All patients discharged were followed up for a median of 13.5 months (3～25 months).The cardiovascular event were observed including cardiac death or readmission due to decompensated HF.Results　Among 78 patients, 4 patients failed to be followed up，there were 38 patients in the events group，36 patients in non-event group.(1)Compared with non-event group, the event group had a significiant higher SUA level ［(576.7±182.9)μmol/L vs (462.4±164.2)μmol/L］, P<0.01.(2)Area under the curve for SUA in evaluating prognosis of DCM patients was 0.673,optimal cut point was 565 μmol/L,sensitivity 0.579,specificity 0.778.(3)The analysis of Kaplan-Meier survival curve showeded,SUA>565 μmol/L on adminssion were associated with increased cardiovascular events.The risk of recurrent cardiovascular events of group with SUA>565 μmol/L was 4.813 times as much as that of group with SUA≤565 μmol/L(Hazard Ratio［HR］=4.813, 95%CI：1.742～13.292，P=0.002).Conclusion　SUA level has important prognosis value in patients with DCM. SUA>565 μmol/L predicted an unfavourable prognosis.]]> 2017/12/18 8:27:35 ZHANG Zhi-yang, CAI Wei-ping, LIN Dong-heng, et al. 371true ［Abstract］　Objective　To observe the etiological distribution and imaging features of pulmonary fungal disease that was diagnosed by pathology in the People′s Hospital of Guangxi Zhuang Autonomous Region.Methods　Fifty-night patients with pulmonary fungal disease were collected and analyzed in the People′s Hospital of Guangxi Zhuang Autonomous Region from June 2004 to March 2013.The diagnosis of all the patients was confirmed by pathological examination,of lung or bronchi tissue that was obtained by bronchoscope, percutaneous lung puncture biopsy or operation.Results　Of the 59 patients who were diagnosed having pulmonary fungal disease by pathology, 24 patients(40.7%) suffered from pulmonary aspergillosis，24 patients(40.7%) suffered from pulmonary cryptococcosis, 5 patients(8.5%) suffered from pulmonary mucormycosis, 4 patients(6.8%) suffered from pulmonary candidiasis, 2 patients(3.4%) suffered from histoplasmosis, 1 patients(1.7%) suffered from actinomycetes pneumonia. Imaging manifestations of chest included lung mass in 23 cases（39.0%）, exudative process in 23 cases（39.0%）, lung nodes in 8 cases（13.6%）, bronchus neoplasm in 3 cases（5.1%）, cavitary lesions in 1 cases（1.7%）, diffuse lesions in 1 cases（1.7%）.Of the 59 patients, pulmonary fungal disease was misdiagnosed as pneumonia in 12 cases（20.3%）, pulmonary tuberculosis in 7 cases（11.9%）, and lung cancer in 4 cases（6.8%）.Conclusion　The pulmonary aspergillosis and cryptococcosis is common in pulmonary fungal disease diagnosed by pathology，and the imaging manifestations of chest mainly include lung mass and exudative process. Imaging manifestations of chest of pulmonary fungal disease are multifarious and have no characteristics. Thus diagnosis should be confirmed by pathological evidence as soon as possible.]]> 2017/12/18 8:27:35 LIANG Da-hua, QIN Zhi-qiang, WEI Hai-ming, et al. 370true ［Abstract］　Objective　To explore the effects of Vita 3D all-ceramic restoration in repairing dental defect or deletion.Methods　In 49 patients with dental defect or deletion 56 teeth were restored with Vita 3D all-ceramic restoration and followed up for 1 to 2 years.Results　Of 56 restored teeth,54 crown or bridges were sealed and had good retentive power, reached class A in marginal integrity,crown coloring,pier periodontal pocket,without loosing and shedding；2 crowns of front teeth were cracked but not fractured two years after repairing, the success rate was 96.43%(54/56).Conclusion　Vita 3D all-ceramic restoration may be used in the repairing of dental defect or deletion, and the repairing effect is fine.]]> 2017/12/18 8:27:35 ZHONG Ai-xi, PENG Li-hui, PAN Xiao-bo, et al. 369true ［Abstract］　Objective　To observe the efficacies and toxicities of the modified DCF regime in the treatment of advanced gastric cancer.Methods　Thirty-three patients with advanced gastric cancer, diagnosed by histopathology and imaging, were treated with the modified DCF regime. Each patient received at least 2 cycles of the treatment. The efficacies and toxicities were evaluated after treatment.Results　Among thirty-three patients,the overall response rate was 51.5%(CR in 1 patients,PR in 16 patients).The main toxicities were myelosuppression and gastrointestinal reactions.Conclusion　The effect of the modified DCF regime in the treatment of advanced gastric cancer is better,and the toxicities are tolerable.]]> 2017/12/18 8:27:35 YU You -gui,YANG Xiu-fang,CHEN Mei 368true ［Abstract］　Objective　To investigate the influence of different anesthesia methods on elderly patients′ postoperative cognitive dysfunction by mini-mental state examimation(MMSE) to test neuropsychology.Methods　From January 2010 to January 2011 180 elderly patients with ASAⅠ～Ⅱ,who underwent selective non-cardiac surgery, were randomized into two groups, with 90 cases in each group. One group was treated with epidural anesthesia(epidural group) and the other with general anesthesia(general group). The general situation was compared between two groups. The scores of MMSE before anesthesia, at 3 hours, 9 hours,3 days,5 days after operation and rate of postoperative cognitive dysfunction(POCD) were recorded.Results　There was no significant difference in general situation between two groups(P>0.05).The score of MMSE after anesthesia in each group were all reduced;The score of MMSE in two groups were statisticant differences（P<0.05）; The score of MMSE in different times were statisticant differences（P<0.05）.There was significant difference in rate of POCD between epidural group and general group at 3 hours and 9 hours after operation(P<0.05). There was no significant difference in rate of POCD between epidural group and general group at 3 days and 5 days after operation(P>0.05).Conclusion　Both of epidural anesthesia and general anesthesia associated with postoperative cognitive dysfunction，but general anesthesia technique has a powerful influence on cognitive function than epidural anesthesia.]]> 2017/12/19 8:06:01 MA Ya-bing 367true ［Abstract］　Objective　To analysis 64-slice CT angiography imaging features of carotid atherosclerotic plaque and explore the relationship between different types of carotid atherosclerotic plaque and ischemic cerebral stroke.Methods　The clinical data of 60 cases of ischemic cerebral stroke were retrospectively analyzed, all the cases were underwent 64-detector row CT angiography,and the distribution, character and morphological characteristics of carotid atherosclerotic plaque, and morphological characteristics and the extent of stenosis were observed with the original axial image,volume rendering(VR) and curved planar reconstruction(CPR).Results　In the 60 cases of ischemic cerebral stroke,58 cases with carotid atherosclerotic plaque were found.A total of 228 plaques were detected, including 43 non-calcified plaque, 125 calcified plaque and 60 mixed plaque.In 60 cases, 170 mild stenosis, 20 moderate stenosis, 12 severe stenosis and 1 occlusion were found, no significant stenosis were found in 20 sites. Five calcified plaques were found in intracranial segment of internal carotid artery,and CT can′t evaluate the severity of the stenosis. There was significantly statistical difference in unstable plaque between non-lacunar infarct and lacunar infarct(P<0.05).Conclusion　64-detector row CT angiography of carotid atherosclerotic plaques can accurately detect the distribution, character and morphological characteristics of carotid atherosclerotic plaque and the degree of stenosis of carotid artery,it is a valuable method in prevention, treatment, and prognosis judgement of ischemic cerebral stroke.]]> 2017/12/19 8:06:01 ZHENG Yu- fei, ZHU Li-li, WANG Zhuo-qun, et al. 366true ［Abstract］　Objective　To study of clinical diagnosis and treatment of elderly bronchial asthma patients with pneumonia.Methods　One hundred and twelve elderly patients with bronchial asthma complicated with pulmonary infection were treated for asthma. Sputum culture were performed to find fungal infections. The type of pathogenic bacteria were determined to correctly choose antibiotics.Results　In 112 patients, most had infections due to gram positive bacteria, including spore bacillus, Lester bacteria, Corynebacterium and erysipelothrix. The patients were treated with preferred penicillin combined with aminoglycosides as an anti-inflammatory therapy, the period of treatment was 2～3 weeks. For penicillin hypersensitive patients, tetracycline and chloramphenicol were available. After treatment, 71 cases were cured, 37 cases improved, 4 cases were healed, the healing rate was 96.43%.Conclusion　The elderly patients with bronchial asthma complicated with pneumonia have the history of long time use of corticosteroids, antibiotics and other drugs, coupled with reduced immune function or wasting disease, so in the treatment for these patients diseases the drug intake of treating other should be limieted.]]> 2017/12/19 8:06:01 MENG Jian-feng，LI Chao-qian 365true ［Abstract］　Objective　To explore the diagnosis, clinical pathology, immunohistochemistry, cytogenetics and treatment of granulocytic sarcoma(GS).Methods　The clinical data of 4 cases of GS was analyzed, and the related- literatures were reviewed.Results　Two cases were non-leukemic GS, currently being in continuous complete remission after appropriate treatment. The other 2 cases were leukemic GS: one case originated from acute myeloid leukemia, and the other one originated from chronic myeloid leukemia, the results of the two patients for treatment were poor, the survival time of the two cases was 8 months and 4 months respectively.Conclusion　The diagnosis and differential diagnosis of GS mainly depends on patho-morphology and immunohistochemistry. The prognosis of GS is poor. The early diagnosis, timely implementation of the individualized treatment and early high-intensity chemotherapy can delay the recurrence and improve long-term survival rate; hematopoietic stem cell transplantation can significantly prolong survival time.]]> 2017/12/19 8:06:01 XUE Yan, DUAN Ya-ya, LI Xiao-lin, et al. 364true ［Abstract］　Objective　To analyze the clinical characterstics of patients with primary fallopian tube carcinoma(PFTC) and improve the early diagnostic rate of PFTC.Methods　The clinical data of 14 patients with PFTC treated in the People＇s Hospital of Guangxi Zhuang Autonomous Region from January 2007 to December 2013 were retrospectively analyzed,including clinical manifestations, tumor markers and imaging results.Results　The median age of 14 patients was 52 years old. The clinical manifestations included pelvic mass in 13 patients(13/14), vaginal bleeding in 9 patients(9/14), vaginal discharge in 8 patients(8/14), abdominal pain and abdominal distension in 5 patients(5/14). Fallopian tube carcinoma triad(vaginal discharge, vaginal bleeding and pelvic mass) in 8 patients(8/14).CA125 rose in 10 patients(10/14).Conclusion　For middle-aged and old women with pelvic mass complicated with vaginal bleeding, fluid discharge and symptoms of abdominal pain, abdominal distension and so on, the diagnosis of PFTC should be considered.]]> 2017/12/19 8:06:01 HUANG Hui-yuan，ZHAO Ren-feng， LI Xue，et al. 363true ［Abstract］　Objective　To study the effect of indomethacin on efficacy of total parenteral nutration(TPN) in the patients with esophageal carcinoma after operation.Methods　Sixty-eight patients received TPN for a week postoperatively,34 patients among them also received 100 mg indomethacin rectal suppository,3 times a day. Total protein, albulmin and transferrin in the serum and nitrogen balance were examinated before operation and on the 1st day, the 3rd day and the 7th day after operation.Results　There was significant increase in transferrin and decrease in negative nitrogen balance in the group of opatients taken indomethacin rectal suppository,suggesting a increase in protein synthesis.Conclusion　Indomethacin could improve the efficacy of TPN after operation.]]> 2017/12/25 16:01:51 LIN Shan-wen, ZHONG Cheng-hua, LIANG Jian, et al. 362true ［Abstract］　Objective　To analyze the manifestations of MR T₂WI and dual echo T₁WI in liver hemochromatosis, and evaluate the value of MRI in the diagnosis of live hemochromatosis.Methods　The MRI of 27 confirmed patients with liver hemochromatosis were retrospectively analyzed, the liver signal intensity on T₂WI and dual echo T₁WI were observed.Results　All 27 patients′ T₂WI showed liver signal intensity reduced in a certain extent, closed to or lower than the sacrospinal muscle signal intensity on the same slice. Dual-echo T₁WI also showed the liver signal intensity reduced in both in-phase and opposed-phase images, however on the in-phase images the signal intensity′s loss was more obvious than the opposed-phase images. The liver signal intensity was higher on the opposed-phase images than the in-phase images.Nine patients showed signal intensity reduced in spleen, and also display higher signal intensity on opposed-phase images.Conclusion　T₂WI combined with dual echo T₁WI have high degree of sensitivity and specificity for the diagnosis of hemochromatosis. MRI has very important clinical value for early diagnosis and treatment monitoring of hemochromatosis.]]> 2017/12/25 16:01:51 YU Shui-lian, MA Long-bai, LIU Ying 361true ［Abstract］　Objective　To explroe the clinical value of low frequency repetitive transcranial magnetic stimulation in improving obstinate auditory hallucinations and cognitive function in patients with schizophrenia.Methods　According to visit order number 100 patients with schizophrenia were divided into control group and observation group,with 50 cases in each group. The control group was treated with risperidone. The observation group was treated by risperidone combined with low frequency repetitive transcranial magnetic stimulation.Before and after treatment, the patients were evaluated, by auditory hallucinationsrating scale(AHRS) and Treatment Emergent Symptom Scale(TESS) and assessment of verbal fluency and trail making were performal in patients.Results　After 8 weeks of treatment,the AHRS scores in the observation group were lower than that in the control group, with statistical significance between two groups(P<0.05); The observation group′s verbal fluency obviously improved than before treatment(P<0.05), the control group′s verbal fluency did not show no significant improvement(P>0.05).There was no significant difference in trail making between the two groups before and after treatment(P>0.05).Conclusion　Low frequency repetitive transcranial magnetic stimulation can effectively improve obstinate auditory hallucinations in elderly patients with schizophrenia, and has certain effect in improving their cognitive function,and is worthy of clinical reference and promotion.]]> 2017/12/25 16:01:51 YUAN Hai, MENG Fan-rong, YUAN Cheng-yong 360true ［Abstract］　Objective　To investigate the effect to treat stress urinary incontinence(SUI) in the aged females by electrical stimulation combined biofeedback.Methods　Fifty-seven aged patients with SUI were carried out biofeedback electrical stinulation by the devices of PHENIX USB4(made by the company of Electronic Concept Lignon Innonation) for 1 or 2 period of treatment.In 3 month after treatment, the effect was evaluated by the symptom and the objective index.Results　After treatment,the total efficient ratio was 78.9%,with cured ratio 36.8%,ameliorative ratio 42.1%,resultless ratio 21.1%.Those patients with uterine prolapse /cystocele/ urethrocele/rectocele had a sense of abridgement of the bumps.Sex life was improving in the 34 cases with dissatisfied sex life before treatment.The muscle strength testing scores of type Ⅰ～Ⅱ pelvic floor muscle increased evidently（P<0.05）. Muscle electrophysiology average was elevated（P>0.05). Fatigue test improved in type-Ⅱ pelvic floor muscle（P<0.05）,but decreased in type-Ⅰ pelvic floor muscle（P>0.05).Leakage times(LT) and abnormal A3 reaction was significantly lower after treatment than those before treatment（P<0.05）.Conclusion　Electrical stimulation combined with biofeedback was one kind of efficacious and harmless way for treating SUI in the aged females，worthy of using widely.]]> 2017/12/25 16:01:51 WU Yue-lian, LIN Hai-yan, ZHAO Ren-feng, et al. 359true ［Abstract］　Objective　To explore the clinical effects of laparoscopic splenectomy（LS）.Methods　In 12 patients undergoing LS,the operative time, blood loss, fasting time, postoperative wound pain scores, postoperative hospital stay were observed and analyzed.Results　The operative time was 155～182 min, with an average of 170 min; intraoperative bleeding was 85～100 ml, with an average of 94 ml; the postoperative fasting time was 24～48 h, with an average of 40 h; On the first postoperative day,the wound pain score was 2～4, with an average of 3.1 points; third postoperative day incision pain score was 1～2 points, with an average of 1.2 points; postoperative hospital stay was 6～8, with an average of 7.3 days.Conclusion　This method has some superiorities, including less trauma, less patients′ pain, less blood loss, faster recovery, fewer complications, a small incision pain, shorter hospital stay, and so on. It is the best choice for splenectomy patients.]]> 2017/12/25 16:01:51 BI Yong-hui, SUN Shao-wei, Lin Xin-xing 358true ［Abstract］　Objective　To study the influences of different periods of cranioplasty combined with ventriculoperitoneal shunt(VPS) on the prognosis of patients with skull defects after the operation of craniocerebral trauma and hydrocephalus.Methods　154 patients who suffered from brain trauma and were treated with cranioplasty and VPS were retrospecively analyzed. According to the different periods of cranioplasty combined with VPS, the patients were randomly divided into two groups: early shunt combined with cranioplasty group(the concurrent group) and early shunt and delayed cranioplasty group(the delayed group). The clinical effects and complications were compared between the two groups after the operation.Results　GOS and GCS scores were higher in the concurrent group than those in the delayed group(P<0.05). The incidence of complications was significantly lower in the concurrent group than that in the delayed group(P<0.05).Conclusion　The treatment of early VPS combined with cranioplasty can markedly relieve the patients′ disorders of consciousness and neurological deficits, reduce the complications and improve the prognosis.]]> 2017/12/4 8:38:51 WANG Guang-ming, CHENG Yi, HU Ke-liang 357true ［Abstract］　Objective　To explore the clinical features and prognosis on the adult patients with noncompaction of ventricular myocardium(NVM).Methods　The data of 13 adult patients with NVM from March 2008 to May 2013 were analyzed retrospectively.Results　Among all patients, 8 patients were misdiagnosed as dilated cardiomyopathy, 3 patients were misdiagnosed as coronary heart disease and 2 patients were misdiagnosed as heart valve disease. Examined by echocardiography, 12 cases were found having left atrium and left ventricular dysfunction, 1 case having left and right atrioventricular dysfunction. Ejection fraction was less than 50% in 9 cases. Ventricular wall motion diffuse was decreased in 7 cases. 12 cases suffered from different types of arrhythmia, while electrocardiogram retain normal in 1 case. Cardiac failure, arrhythmia and other complications were controlled when needed. 2 patients with no symptoms didn′t take any medication. After a follow-up for 12 to 26 months, left ventricle was progressively amplified in all patients with cardiac failure, with aortic insufficiency in 1 case, thrombosis in 2 cases and cardiac function NYHAⅣ in 1 case.Conclusion　There are great differences of the clinical manifestations among the patients with NVM. Awareness of the disease should be raised in physicians and ultrasound doctors to recognize it better and to reduce missing diagnosis and to improve the patients′ prognosis.]]> 2017/12/4 8:38:51 LI Sheng-li, LI Mu-wei 356true ［Abstract］　Objective　To analyze the diagnostic value of ultrasound for postmenopausal women with ovarian neoplasm.Methods　The data of ultrasound in 56 patients with ovarian neoplasm were collected from October 2011 to October 2014.Results　In the 56 patients, 40 cases were diagnosed as having benign tumors(71.4%), 16 cases as having malignant tumors(28.6%). Cystic tumors were significantly higher in the benign group than those in the malignant group(P<0.01); The ultrasonic features of the malignant group in shape, solid, wall structure, internal blood flow, ascites, and RI(<0.43) were higher than those in the benign group(P<0.05). Compared with the pastoperative pathological diagnosis, the ultrasonic diagnosis had an accuracy of 92.86%, with the sensitive rate in 97.37% and speciality rate in 83.33%.Conclusion　Ultrasound can quickly and effectively identify the nature of ovarian neoplasm in postmenopausal women and may be used as the preferred clinical screening for ovarian masses.]]> 2017/12/4 8:38:51 ZHANG Xiao-hong, ZHU Dan-ru, QI Dong 355true ［Abstract］　Objective　To study the effects of dexmedetomidine on the anterograde amnesia in patients with different ages.Methods　One hundred and twenty ASAⅠ～Ⅱ patients, age from 18 years to 84 years, 73 cases of male and 47 cases of female, who were dministered spinal-epidural anesthesia combined with dexmedetomidine and performed operation on hypogastrium(except for caesarean section). All patients were randomly divided into four groups: group A, group B, group C and group D. Dexmedetomidine(1 μg/kg) was infused intravenously for 10 min and the maintenance dose was 0.2 μg·kg^-1·h^-1. The anterograde amnesia degree of dexmedetomidine was assessed 24 h after the operation.Results　There was no significant difference in the anterograde amnesia of dexmedetomidine between group A and group B（P>0.05），while there were significant differences in group C and group D compared with both group A and group B（P<0.05）.Conclusion　Anterograde amnesia occurs after using dexmedetomidine in elderly patients and with aging, the anterograde amnesia becomes more severe.]]> 2017/12/4 8:40:13 HU Zhi-chao, KONG Li, XU Peng-cheng, et al. 354true ［Abstract］　Objective　To explore the influences of borneol and muscone on blood-brain barrier permeability of nerve growth factors.Methods　Thirty-two Wistar rats aged 7 days old were divided into the muscone group, borneol group, control group and borneol+muscone group, with eight rats in each group. The levels of nerve growth factors passing the blood-brain barrier and neural function behavior scores of the patients in the four groups were analyzed and compared.Results　The levels of nerve growth factors in Evans blue, brain tissue and blood of rats in the borneol+muscone group were higher than those in the other three groups. Neural function behavior score of rats in the borneol+muscone group was lower than that in the other three groups(P<0.01). There were no significant differences in the content of Evans blue, level of nerve growth factors and neural functional behavior scores between the borneol group and the muscone group(P>0.05). The content of Evans blue, level of nerve growth factors, neural function behavior scores in the borneol group and the muscone group were higher than those in the control group(P<0.01).Conclusion　Muscone and borneol can raise the permeability of blood-brain barrier and get nerve growth factors across the blood-brain barrier better.]]> 2017/12/4 8:40:13 ZHAO Ting-jian, ZHANG Pei-lin, ZHOU Yong, et al. 353true ［Abstract］　Objective　To investigate the efficacy of fractionated ultrapulse CO₂ laser with MEBO in treating atrophic acne scar.Methods　Sixty patients with atrophic acne scar were divided into the treatment group(fractionated ultrapulse CO₂ laser with MEBO) and the control group(fractionated ultrapulse CO₂ laser with Erythromycin eye ointment). Their clinical effects were observed.Results　The improvement index of scar in the treatment group was better than that in the control group（Z=2.170,P=0.029）.Conclusion　Fractionated ultrapulse CO₂ laser with MEBO is an effective and safe way to treat atrophic acne scar, and is better than fractionated ultrapulse CO₂ laser with Erythromycin eye ointment.]]> 2017/12/4 8:40:13 LI Feng-chun, HE Ren-liang, YANG Zhi-bo, et al. 352true ［Abstract］　Objective　To investigate the clinical manifestation and pertinent treatment for cesarean scar pregnancy(CSP).Methods　8 patients received uterine artery embolization and other 13 patients received mifepristone combined with methotrexate treatment.Results　The time of β-HCG reducing to the nomal level were （28±0.3）d and （24±0.1）d in the above two groups respectively; Lumps disappear at （29±0.5）d and（25±0.7）d in the above two groups respectively; The average hospital stays were （23±0.3）d and （18±0.2）d in the above two groups respectively.Conclusion　Methotrexate combined with mifepristone is a safe and effective treatment for CSP.]]> 2017/12/4 8:40:13 ZHANG Xu-dong 351true ［Abstract］　Objective　To explore the expression and significance of CD4⁺CD25⁺ regulatory T cells (Treg) for the patients with leucopenia pneumonia(LP).Methods　Forty patients with LP were enrolled and their blood routine examination, Treg testing and sputum cultivation were done. The correlations between Treg, white blood cell(WBC) and pathogens were analyzed.Results　Compared with the control group, Treg, WBC and monocytes(MON) decreased significantly(P<0.05).Sputum cultivation showed that there were 26 patients suffering from mycoplasma(MP) infection and they were all treated with azithromycin. The frequencies of Treg on the 3^rd day of the MP patients were significantly higher than those on the 1st day during azithromycin treatment(P=0.028). Correlation analysis showed that Treg was positively related to WBC and MON(P<0.05), whereas Treg was negatively related to neutrophil granulocyte and lymphocyte, as well as the MP(P<0.05).Conclusion　Decreasing of Treg is one of the important immunological features for patients with LP, which can help the early diagnosis and curative effect evaluation for the MP.]]> 2017/12/4 16:23:24 LIN Yan-mei 350true ［Abstract］　Objective　To investigate the value of galactomannan antigen assay and 1, 3 beta-D-glucan assay in bronchoalveolar lavage fluid(BALF) in the early diagnosis for invasive aspergillosis.Methods　A total of 32 patients with invasive aspergillosis and 24 patients with bacterial infections were performed G test and GM test and the levels of BG antigen and GM antigen were measured. The sensitivity, specificity, positive predictive values and negative predictive value were calculated. The ROC curve was used to compare the diagnostic values of G test and GM test, with kappa values to illustrate the consistency of G test and GM test.Results　The sensitivity, specificity, positive predictive values and negative predictive value were 84.38%, 83.33%, 87.10% and 80.00% respectively in G test, and 81.25%, 87.50%, 89.66% and 77.78% respectively in GM test. The levels of BG antigen and GM antigen in patients with invasive aspergillosis were significantly higher than those in patients with bacterial infection(P<0.05). The areas under the ROC curve were respectively 0.839 and 0.844 in G test and GM test, with kappa value 0.57(P>0.05). The sensitivity of G test was slightly higher than that of GM test, while the specificity of the G test was slightly lower than that of GM test, without a significant difference(P>0.05).Conclusion　BALF G test and GM test is very important for early diagnosis of invasive aspergillosis.]]> 2017/12/4 16:23:24 CHEN Hui-peng, ZHONG Ru-zhu, LI Li 349true ［Abstract］　Objective　To explore the clinical features and outcomes of pregnancy on monochorionic selective fetal growth restriction.Methods　124 patients with monochorionic twin pregnancy(≥28 weeks) in the obstetrical department of our hospital were collected from August 2012 to September 2014 as the study objects, among which 22 cases with selective fetal growth restriction were taken as the experimental group, and the other 102 developmental normal cases as the control group. The pregnancy complications, mode of delivery and perinatal prognosis situation were compared between the two groups.Results　The incidence of pregnancy induced hypertension, perinatal mortality, the occupancy rate of NICU, mild and severe asphyxia of newborn were higher in the experimental group than those in the control group(P<0.05).Conclusion　Compared with developmental identity twins, the perinatal mortality of monochorionic selective fetal growth restriction is significantly higher in the early detection of monochorionic twin pregnancies selective intrauterine growth restriction, which indicates that prenatal care and proper intervention can effectively improve the fetus and newborn prognosis.]]> 2017/12/4 16:23:24 LI Yue 348true ［Abstract］　Objective　To explore the risk factors of pulmonary fungal infections in elderly patients with chronic obstructive pulmonary disease(COPD).Methods　85 COPD patients complicated with pulmonary fungal infections and other 60 COPD patients without pulmonary fungal infections were selected. The clinical data of the two groups were collected and comparatively analyzed. Meanwhile, the distribution of funguses was observed by fungal cultures and identification.Results　There were significantly differences in the time of using antibacterial drugs, the levels of serum albumin, the numbers which used glucocorticoid more than 2 weeks, complication with diabetes, respiratory failure, and using mechanical ventilation between the observation group and the control group(P<0.01). Multifactor regression analysis indicated that long-term use of antibiotics, glucocorticoid, hypoalbuminemia, diabetes and respiratory failure, mechanical ventilation were the risk factors of pulmonary fungal infections in elderly patients with COPD(P<0.05). In fungal infections, the main strain is Candida, among which Candida albicans accounted for the highest detection rate.Conclusion　Antibiotics and glucocorticoid should be rationally used for the treatment of COPD and avoiding excessive use of invasive mechanical ventilation and paying more attention to the treatment of complications are also helpful for pulmonary fungal infections.]]> 2017/12/4 16:23:24 JIN Ni-na, SUN Yan-hua, ZUO Wan-li, et al. 347true ［Abstract］　Objective　To evaluate postpartum pelvic floor disorder through assessing the pelvic floor function and compare the effects of two kinds of delivery modes, cesarean section and vaginal delivery on postpartum pelvic floor function and provide a theoretical basis for the prevention and treatment of pelvic floor dysfunction(PFD).Methods　800 postpartum women who revisited the outpatient department 6 to 8 weeks after childbirth were collected from January to June 2014 and divided into caesarean delivery group(n=288) and vaginal delivery group(n=512) according to the different modes of delivery. Routine assessment of pelvic floor function was retrospectively analyzed and compared between the two groups.Results　Among 800 patients who were screened by the manual muscle test combined with the assessment of pelvic floor function. The damage of muscle fiber type Ⅰ was found in 185 cases and the damage of muscle fiber type Ⅱ in 168 cases in the cesarean delivery group; the damage of muscle fiber type Ⅰ was found in 504 cases and the damage of muscl fibere type Ⅱ in 502 cases in the vaginal delivery group. There was significant difference between the two groups(P<0.01). The impaired muscle strength, muscle injury, abnormal muscle fatigue and the vaginal dynamic pressure value <80 cmH₂O were more severe or higher in vagina delivery group than those in the caesarean delivery group(P<0.05).Conclusion　Compared with vaginal delivery, cesarean section has less adverse effects on pelvic floor function. However, the impaired pelvic floor function can be recovered by carrying out postpartum rehabilitation exercise, so it should not be based on the choice of delivery modes.]]> 2017/12/4 16:23:24 GONG Tian-liu 346true ［Abstract］　Objective　To evaluate the clinical efficacy of drug combined with behavioral intervention therapy in the treatment of adult patients with gastroesophageal reflux disease(GERD).Methods　100 adult patients with GERD were randomly divided into drug group and comprehensive group. The drug group was treated with conventional drugs,and the comprehensive group was added the treatment of behavioral intervention therapy on the basis of conventional drugs. The changes of parameters in the two groups were analyzed before and after the therapy and the compliance was compared between the two groups.Results　The symptoms were both improved in the two groups after 8 weeks′ treatment. The symptoms in the comprehensive group were improved better than those in the drug group (P<0.01). The compliance of the drug group was better than that of the comprehensive group(P<0.05).Conclusion　Drug therapy combined with behavioral intervention is efficient for the treatment of GERD.]]> 2017/12/4 16:23:24 JIANG Rui 345true ［Abstract］　Objective　To investigate the CT features of inflammatory myofibroblastic tumor(IMT).Methods　The CT imagings and clinical data of 19 patients with IMT confirmed by pathological examination were analyzed retrospectively. Of all the patients with IMT, there were 6 tumors in lungs, 5 in enterocoelia, 4 in liver, 1 in neck soft tissue, stomach, trachea and middle fossa.Results　The CT findings indicated that 14 lesions in heterogeneous low-density on CT plain scanning, 4 lesions in high-density and 1 lesion in isodensity, 17 lesions in round shape or irregularity bolus, 2 lesions in cyst-solidary mass in enterocoelia. Calcification was found in the lung of 1 case and in the stomach of 1 case. Enhanced scanning showed mild to moderate enhancement in 15 cases in the arterial phase, persistent enhancement in the portal venous phase or in the delayed phase, ring-like enhancement in 1 case in the liver.Conclusion　CT features combined with the clinical data are helpful to diagnose IMT.]]> 2017/12/6 8:06:37 TANG Qian, LI Kai, LONG Li-ling, et al. 344true ［Abstract］　Objective　To comparatively analyze the induced labor intervention and natural labor for gestational diabetes pregnant childbirth way and the birth outcomes.Methods　422 cases of the term delivery of women with gestational diabetes mellitus were retrospectively analyzed, with 231 cases in the induced labor group and 191 cases in the natural labor group. Maternal blood glucose value before termination of pregnancy, childbirth way and the perinatal complications were compared between the two groups.Results　Satisfaction rate of blood sugar control in the induced labor group was significantly higher than that in the natural birth group(88.7% vs 74.3%). Fasting blood-glucose and 2-hour postprandial blood glucose were significantly lower in the induced labor group than those in the natural labor group［（5.1±0.8) vs (5.7± 1.0）mmol/L and （6.3±0.6) vs (6.8±1.2）mmol/L］. These differences were statistically significant（P<0.01）. Cesarean section rate was 59.7% in the induced labor group and 58.6% in the natural labor group. There was no significant difference between the two groups（P>0.05）. However, the ratio of the former with fetal distress for cesarean section indications was significantly lower in the induced labor group than that in the natural labor group. The patients′ own requirements for indications were significantly higher in the induced labor group than those in the natural labor group（P<0.01）. The incidence of perinatal complications of the selective induced labor group was significantly lower than that of the natural labor group (6.5% vs 22.5%, P<0.01）.Conclusion　Selective induction of intervention can help stabilize the maternal blood glucose level and effectively reduce the rate of fetal distress to cesarean section,but has no obvious effect on reducing the rate of cesarean section.]]> 2017/12/6 8:06:37 SHEN Shu-jing 343true ［Abstract］　Objective　To evaluate the feasibility and effectiveness of laparoscopic vaginoplasty with pelvic peritoneum.Methods　The surgical conditions and follow-ups of 27 cases with congenital absence of vaginas and uteri who were performed laparoscopic vaginoplasty with pelvic peritoneum were analyzed retrospectively.Results　All of the patients were completed the surgery successfully. The length of their free pelvic peritoneum flaps was separated in 8～10 cm, at the time when their primordial uteri were ressected during the surgical procedure. The operative time and blood loss were 85.00～140.00（100.56±10.00）min, 30.00～150.00（46.81±20.01）ml, respectively. All of them were discharged successfully from the hospital without any operatively related complications. All patients had enough long vaginas without scar contressentire and had normal sexual intercourse satisfactorily after one year of operation.Conclusion　Laparoscopic vaginoplasty with pelvic peritoneum is a feasible and safe surgical pattern for patients in absence of vaginas and uteri. The enough and properly long pelvic peritoneum is proposed to be contained during operation.]]> 2017/12/6 8:06:37 HUANG Wei-rong, WU Yu-ying, ZHAO Ren-feng 342true ［Abstract］　Objective　To investigate the factors of poor virological response to adforvir dipivoxil(ADV) treatment in patients with chronic hepatitis B.Methods　The clinical data of the factors of poor virological response to ADV treatment in patients with chronic hepatitis B were retrospectively analyzed from January 2011 to January 2014.Results　BMI, HBV DNA, HBsAg when HBeAg was positive and BMI, HBV DNA when HBeAg was negative were correlated with the response(P<0.05). There was significantly difference in V of 181 mutations (≥5%) and T of 236 mutations (≥5%) when HBeAg was positive (P<0.05). There was significantly difference in T of 236 mutations (≥5%) when HBeAg was negative(P<0.05). But there were no significant differences in V of 181 mutations(<5%) when HBeAg was negative(P>0.05). HBV DNA which was lower than the basic levels in 12 and 24 weeks after treatment （1.326±0.907）log10copies/ml and (1.279±1.156)log10copies/ml was easy to have the poor virological response(P<0.05) in the HBeAg positive patients. HBV DNA which was lower than the basic levels in 12 and 24 weeks after treatment （0.983±0.706）log10copies/ml and (1.178±0.736)log10copies/ml was easy to have the poor virological response(P<0.05) in the HBeAg negative patients. There were no obvious relationships between the changes of ALT and AST and the response（P>0.05）.Conclusion　The baseline data and the changes of HBV DNA are the factors of poor virological response to ADV treatment in patients with chronic hepatitis B. Individualized treatments should be established according to the above data to reduce the incidence of poor response phenomenon.]]> 2017/12/6 8:06:37 ZHAO Hong-kui, BIAN Cheng 341true ［Abstract］　Objective　To compare the sedative effect and safety of dexmedetomidine and propofol for patients undergoing mechanical ventilation after cardiac surgery.Methods　A total of 70 patients undergoing mechanical ventilation after cardiac surgery in the intensive care unit(ICU) were enrolled. They were treated either with propofol(35 cases in propofol group) or dexmedetomidine(35 cases in dexmedetomidine group). The dose of sedation was regulated by Riker sedation-agitation scale(SAS) maintaining 3～4 sedative score. During the course, the amount of the sufentanil, duration of mechanical ventilation, using time of vasoactive agent, SAS score, extubation time,and incidence of side-effects such as hypotension, bradycardia, delirium or agitation, etc were recorded in the two groups.Results　There was no statistically significant difference in the sedative effect between the two groups. Riker SAS score was maintained in 3～4 sedative scores(P>0.05). When compared with the propofol group, in the dexmedetomidine group, the dose of sufentanil was smaller(P<0.01), extubation time was shorter(P<0. 01), the rates of hypotension and bradycardia were the same(P>0. 05),and the duration of mechanical ventilation, using time of vasoactive agent, SAS score were the same(P>0.05).The rate of delirium or agitation in the dexmedetomidine was lower than that in the propofol group(14.3%vs 40.0%, P<0.05).Conclusion　Sedative effect of dexmedetomidine is satisfactory and effective for patients undergoing mechanical ventilation after cardiac surgery. It can reduce the rate of delirium or agitation.]]> 2017/12/6 16:26:21 ZHANG You-hua, LV Guang-yu, ZHANG Lei, et al. 340true ［Abstract］　Objective　To study the safety and efficacy of laparoscopy and open repair for patients with perforated peptic ulcer.Methods　Articles published in Chinese and English were searched in the Cochrane Library and on the databases of PubMed, EMBASE, CNKI, Wanfang from January 1990 to September 2014, to meet the searching requirements. Meta-analysis was used to analyze the collected data.Results　The data of 6 randomized clinical trials of acceptable quality were collected from the databases,including a total of 682 patients, 362 cases of laparoscopic group and 320 cases of open group. The results showed that there were no statistically significant differences between laparoscopic and open surgery in the operative time(P=0.37), intra-abdominal abscess(P=0.57) and mortality(P=0.34).Conclusion　Laparoscopic surgery is safe and feasible. However, more randomized controlled trials with a greater number of patients need to be performed to confirm such an assumption.]]> 2017/12/6 16:26:21 SUN Xin, GUO Jian-sheng, JIA Wen-bin, et al. 339true ［Abstract］　Objective　To study the effects of dexmedetomidine combined with ketamine on postoperative cognitive dysfunction in elderly patients with burns.Methods　Sixty cases of the elderly patients with burns were administered anesthetic ketamine(group K, n=30) and the other cases were administered anesthetic dexmedetomidine combinedation with ketamine(group DK, n=30). The postoperative cognitive dysfunctions in the groups were observed respectively on the first, the third and the seventh day after operation.Results　Scores of MMSE in the two groups were both decreased compared with pre-operation(P<0.05). On the third and seventh day the scores in the two groups were increased than those on the first day in some extent, but they were both significantly lower than those before operation（P<0.05）. The score of group K was significantly decreased compared with group DK（P<0.05）. The percentages of POCD in both group K and group DK had no significant difference（P>0.05）.Conclusion　Dexmedetomidine combined with ketamine in anesthesia improves postoperative cognitive dysfunction in elderly patients with burns compared with using ketamine alone. It has no effect on the occurrence of POCD.]]> 2017/12/8 8:10:56 HU Zhi-chao, KONG Li, XU Peng-cheng, et al. 338true ［Abstract］　Objective　To study the relationship between the carotid atherosclerotic plaque and blood glucose fluctuations in patients with type 2 diabetes(T2DM).Methods　According to the carotid artery color doppler ultrasonography, 198 patients with T2DM were divided into no carotid sclerosis group(group A, n=53), the stable carotid atherosclerosis plaque group(group B, n=68), and unstable carotid atherosclerosis plaque group(group C, n=77). Dynamic glucose monitoring system(CGMS) was used to continuously monitor 72 h blood sugar, calculate the mean blood glucose(MBG), within-day mean amplitude of glycemic excursion(MAGE), and recorded the age, blood pressure, glycated hemoglobin(HbA1c), serum total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), and gender.Results　Among the three groups, there were statistically significant differences in systolic pressure, diastolic blood pressure, FPG, TC, HDL-C, LDL-C and HbA1c, and MBG, MAGE gradually increased with the degree of carotid artery atherosclerosis(all P<0.05).Conclusion　In patients with T2DM, the blood sugar fluctuation increases the risk of carotid atherosclerotic plaques, therefore the dynamic blood sugar monitoring should be paid attention to.]]> 2017/12/8 8:10:56 TAN Jie-lin 337true ［Abstract］　Objective　To investigate the clinical characteristics of huge goiter and main problems of surgical treatment for huge goiter.Methods　A respective study was performed in 50 patients with huge goiter whose diameter was larger than 8 cm, during June 2010～June 2012.Results　Thirty patients underwent one lobe thyroidectomy plus one lobe subtotal thyroidectomy, 14 patients underwent one lobe thyroidectomy, 4 patients underwent total thyroidectomy, 2 patients underwent total thyroidectomy plus prophylactic peripheral lymph nodes(PLN) dissection. Pathologic diagnosis showed nodular goiter in 39 cases, carcinoma of thyroid in 8 cases, secondary hyperthyroidism in 3 cases. Postoperative complications were found in 16 cases, including hypothyroidism in 8 cases, hypoparathyroidism in 4 cases, huarseness in 3 cases, postoperative bleeding in 1 case. No death occurred.Conclusion　Huge goiter was usually complicated by substernal goiter, causing tracheal compression,narrow and displacement, so operation for huge goiter is relatively difficult with correspondingly high operation risk and morbidity. It is necessary to treat the patients according to their different conditions and to prevent the injuries of blood vessels, recurrent laryngeal nerve and parathyroid.]]> 2017/12/8 8:10:56 ZHANG Ya-feng, ZHANG Rui-ming 336true ［Abstract］　Objective　To compare the influence of epidural anesthesia and general anesthesia on the postoperative cognitive function in elderly patients with lung cancer.Methods　Ninety-three lung cancer patients who were older than 60 years, planned for selective radical resection of pulmonary carcinoma, were assigned to receive either epidural anesthesia(observed group, n=46) or general anesthesia(control group, n=47). Mini-mental state examination(MMSE) was performed respectively at the time of preoperative 1 day, postoperative 6 hour, 1 day, 3 day and 7 day to assess the patients′ cognitive function. Blood samples were collected at the moment of preoperative 10 min, postoperative 30 min, 1 day and 3 day for the detection of serum concentration of S100-β protein.Results　Significant difference in postoperative MMSE score was associated with the methods of anesthesia and postoperative time, and there was interaction between the methods of anesthesia and postoperative time. MMSE score at the moment of post-6 h was lower than that at the time of pre-1 d in each group(observed group: P=0.000; control group: P=0.000, respectively), at the time of post-6 h and 1 d, the MMSE score in the control group was lower than that in the observed group(P=0.003, P=0.007, respectively). The incidence of postoperative cognitive dysfunction(POCD) at the time of post-6 h in the observed group was lower than that in the control group(13.0% vs 31.9%, P=0.030). Significant difference in serum S100-β protein level was associated with postoperative time, the serum S100-β protein level at the time of post-30 min was higher than that at the time of pre-10 min in each of group(observed group: P=0.010; control group: P=0.000, respectively); but no significant difference of S100-β protein level was found between the two groups at post-30 min, 1 d and 3 d.Conclusion　Epidural anesthesia exerts limited influence on cognitive function and lower incidence of POCD for elderly patients with lung cancer, compared to general anesthesia.]]> 2017/12/8 8:10:56 WU Fang-lan, MO Li-qin, CHEN Xiang, et al. 335true ［Abstract］　Objective　To study the clinical value of trans-umbilical single port laparoscopic high sac ligation for indirect inguinal hernia in children.Methods　Retrospective analysis was performed on clinical data of 58 children received trans-umbilical single port laparoscopic high sac ligation for indirect inguinal hernia.Results　The operation was successfully completed in all of the cases. No conversion to laparotomy was required in all cases. No visceral injury or injury of vas deferens and spermatic vessels were observed. They were followed up for 2～15 months, during which no recurrence, testicular atrophy and iatrogenic cryptochidism were found.Conclusion　The trans-umbilical single port laparoscopic high sac ligation is a safe, effective, convenient and minimal procedure for the treatment of indirect inguinal hernia in children. The operation procedure is more complicated and needs more skillful specialists.]]> 2017/12/12 9:29:09 LIU Yang-hua, FENG Ze-rong, LU Guo-hao, et al. 334true ［Abstract］　Objective　To observe the curative effect and target dose and the safety of carvedilol in the treatment of children with chronic congestive heart failure(CHF).Methods　Ninety children with CHF were randomly divided into 3 groups:ordinary regimen group(n=30), metoprolol regimen group（n=28) and carvedilol regimen group（n=32). The three groups were treated with routine therapy(diuretic, ACEI or digitalis), treatment groups were treated with carvedilol or metoprolol in addition to routine therapy.The serum levels of BNP were measured by enzyme-linked immune absorbent assay. The heart rate，cardiothoracal ratio(CTR), left ventricular end diastol diameter （LVEDD）, left ventricular end systolic diameter（LVESD） and the left ventricular ejection fraction(LVEF) were measured by X-ray and echocardiogram before and 6 months after treatment.Results　（1）After treatment, the clinical symptoms were significantly improved, CTR, heart rate, cardiac function grades decreased, and ejection fraction(EF) was significantly increased showing carvedilol group was superior to metoprolol group(P<0.01).（2）The LVEDD and LVESD were notably decreased after treatment with carvedilol.There were significant difference. Compared with metoprolol group, there was a great significant difference(P<0.05). （3）Plasma concentration of BNP was significantly decreased, carvedilol was more effective than the other two groups（P <0.01）.Conclusion　Carvedilol can prevent and reverse the neurohumoral disorders in chronic heart failure and can improve the cardiac function of children with CHF. Carvedilol is effective and safe in the treatment of children with CHF and superior to metoprolol.]]> 2017/12/12 9:29:09 WANG Li-yan, WANG Wen-di, QIAO Ling-yan, et al. 333true ［Abstract］　Objective　To explore the effects of different doses of olanzapine treatment on blood glucose and lipids in male schizophrenics.Methods　Sixty male schizophrenic patients were divided into two groups randomly and olanzapine were given at 5～15 mg per day(low dose group) and 16～25 mg per day(high dose group). Weight, blood glucose and lipids were measured before treatment and after 28 days′ treatment meanwhile PANSS was used to assess the psychological symptoms.Results　Weight gains in the two groups were significant after treatment(t=11.326, 14.355) and there were significant differences（P<0.01）. There was no significant difference in weight gains between groups after treatment. The serum levels of total cholesterol(TCH) and triglyceride(TG) in the two groups after treatment were increased than those before treatment and there were significant differences（P<0.01）, but there was no significant difference between two groups after treatment. Compared before treatment, there was no significant difference in the levels of glucose and high density lipoprotein-cholesterol(HDL) in the two groups after treatment and there was no significant difference between the two groups(P>0.05). Compared before treatment, the total scores of PANSS in the two groups were decreased after treatment and there were significant differences(P<0.01), but there was no significant difference between two groups after treatment.Conclusion　Olanzapine can increase weight and the level of lipid in male schizoprenic patients and it may not be related with treatment dose.]]> 2017/12/12 9:29:09 ZHANG Dong-wei 332true ［Abstract］　Objective　To investigate the utilization of bisphosphonates agents in outpatients and inpatients of the People′s Hospital of Guangxi Zhuang Autonomous Region, and explore work model and method of special prescription evaluation.Methods　All the electronical prescriptions of bisphosphonates agents of the outpatients and inpatients from April 2013 to March 2014 were analyzed retrospectively.The prescription rate and structure ratio of bisphosphonates agents were calculated.By setting the bisphosphonates agents prescription evaluating standard,the medication rationality of each sample prescription was evaluated and inappropriate prescriptions were classified and analyzed.Results　3 080 bisphosphonates agents prescriptions were collected from outpatients from April 2013 to March 2014 in which zoledronic acid(the prescription rate of 51.75%) and alendronic acid(the prescription rate of 43.54%) were used mostly. 2 958 bisphosphonates agents prescriptions were collected from inpatients from April 2013 to March 2014 in which zoledronic acid(the prescription rate of 63.72%) and pamidronate disodium(the prescription rate of 25.56%) were used mostly. 689 inappropriate prescriptions accounted for 11.67% of the bisphosphonates agent prescriptions.The inappropriate prescriptions were related to inappropriate indication(27.00%),inappropriate usage and dosage(44.99%),drug interaction(19.59%)and other inappropriate prescriptions(8.42%).Conclusion　The practice in special prescription evaluation is helpful to discover some typical inappropriate medications in the prescriptions, which is supposed to provide scientific evidence for intervention and continuous improvement of rational medication.]]> 2017/12/12 9:30:01 CHEN Ying, XI Jia-xi, YE Dong-mei 331true ［Abstract］　Objective　To investigate the clinical therapeutic effect of application of the combination based traditional Chinese and western medicine fast track surgery(CCWFTS) in perioperative period of liver surgery.Methods　Eighty patients receiving liver surgery in our hospital from January 2010 to March 2014 were divided into the control group and the treatment group, 40 cases in each group. The control group was treated by the conventional treatment of western medicine in perioperative period of liver operation. The treatment group was treated by CCWFTS in perioperative period of liver surgery.Results　The operation time was (120±36)min in the treatment group, and (115±43)min in the control group. The difference between the treatment group and the control group was not statistically significant(P>0.05). In the treatment group, the amount of bleeding was (649±60.4)ml, the time of first intestinal ventilation was (46±16.4)h, the CRP after 3 d was (52.4±12.1)mg/L,the albumin after a week was (31.2±2.3)g/L, the weight loss in discharge was (1.5±1.1)kg, the length of stay was (12.6±2.0)d, the hospitalization expense was (35000±13000)yuan(RMB), the rate of infectious complications was 5.0%（2/40）,and those in the control group were (680±56.6)ml,(95±12.6)h,(92.5±11.0)mg/L,(27.7±1.6)g/L,(2.8±1.5)kg,(14.4±2.1)d,(43000±11000)yuan(RMB), 22.5%(9/40).The differences between the treatment group and the control group were statistically significant（P<0.05 or P<0.01）.Conclusion　The combination of CCWFTS in perioperative period of liver surgery is safe, effective and economical. It can speed up the postoperative recovery of the patients significantly.]]> 2017/12/12 9:30:01 CHEN Sheng-gui, HUANG Qiong-fang, LI-Jin, et al. 330true ［Abstract］　Objective　To summarize the surgical treatment experience of severe rheumatic mitral stenosis patients with small left ventricle(left ventricular end diastolic diameter ≤40 mm).Methods　From April 2012 to July 2013, 292 rheumatic heart disease patients including severe mitral stenosis patients with small left ventricle were performed open heart surgery by cardiopulmonary bypass. The clinical data of 3 severe mitral stenosis patients with small left ventricle were analyzed retrospectively.Results　One patient died of multiple organ failure secondary to hypoxemia, pulmonary infection, low cardiac output syndrome and acute renal failure. The other 2 patients were cured and discharged, and their cardiac function recovered to grade Ⅰ～Ⅱ. During the following-up period with 13 to 18 months, left ventricular end diastolic diameters of 2 patients were 45 mm and 46 mm respectively, and left ventricular ejection fractions were 0.78 and 0.76 respectively. The two indexes were improved compared with preoperative indexes.Conclusion　Severe rheumatic mitral stenosis patients with small left ventricle usually associate with long duration, serious condition, tricuspid valve insufficiency and pulmonary arterial hypertension, even a part of patient develops into left ventricular atrophy and right heart insufficiency in advanced stage. Severe rheumatic mitral stenosis patients with small left ventricle have greater operation risk and higher mortality.]]> 2017/12/18 8:27:00 LIU Sheng-zhong, TAN Jin, HUANG Ke-li 329true ［Abstract］　Objective　To explore the value of procalcitonin(PCT) in the discrimination between sepsis due to Gram-negative（GN） bacteria and duo to Gram-positive（GP） bacteria.Methods　One hundred and one sepsis patients with positive blood culture between January 2013 to May 2014 were collected in Guangzhou Red Cross Hospital. Among them, 56 patients were infected with GN bacteria and the other 45 patients were infected with GP bacteria. Serum PCT, hs-CRP and WBC count were detected. Drawing PCT ROC curve aimed to analyze the best cut-off score and the sensitivity and the specificity were made.Results　Serum PCT levels were obviously higher in patients with GN bacteria（M=18 ng/ml）than those in patients with GP bacteria（M=3.6 ng/ml）.According to the ROC curve,the best cut off was 3.22 ng/ml with the sensitivity 86% and the specificity 72% and the area under the curve(AUC) was 0.864.Conclusion　PCT may be a sensitive index for discrimination between sepsis due to Gram-negative bateria and due to Gram-positive bacteria.]]> 2017/12/18 8:27:00 WANG Yan-shuang, HE Ya-jun 328true ［Abstract］　Objective　To investigate the clinical efficacy of myomectomy and B-lynch suture during cesarean section in pregnant women with hysteromyoma.Methods　Forty-four pregnant women with hysteromyoma undergoing myomectomy and B-lynch suture during cesarean section were selected for the observation group,and at the same time, other 44 pregnant women with hysteromyoma undergoing cesarean section and puerperal myomectomy were selected for the control group.The observation indexes were compared between two groups.Results　The operation time of observation group was longer than that of the control group. The average intraoperative blood loss in observation group was 100 ml more than the control group in each case(P<0.01).There were no significant difference between two groups in the anal exhaust time after operation, the puerperal infection rate, the rate of postpartum hemorrhage, the hospitalization time after operation and the time of lochia(P>0.05）.Conclusion　Under the condition of appropriate cases，uterine myomectomy and B-lynch suture during cesarean section does not significantly increase operation difficulty,the bleeding volume postoperative complications, but reduces the re-operation treatment and reduces the economic burden of the patients.]]> 2017/12/18 8:27:00 DAI Bin, CHEN Yan-qin, WEN Jing-huan 327true ［Abstract］　Objective　To explore the relationship between gene P53 expression and sensitivity of esophageal carcinoma to the concurrent radiotherapy and chemotherapy，and provide a prediction for the treatment of esophageal carcinoma.Methods　The expression of P53 mRNA in peripheral blood leukocytes of 50 patients with esophageal carcinoma was detected by RT-PCR(reverse transcription-PCR) method. Patients were treated by 60～70 Gy radiotherapy and two cycles of conventional synchronous DF(fluorouracil and cisplatin) chemotherapy. The relationship between P53 gene expression and therapeutic effect of radiotherapy with concurrent chemotherapy was analyzed.Results　The group of P53-positive patients(n=18) showed complete recovery(CR) in 4 cases, partly recovery(PR) in 8 cases, stability(SD) in 4 cases, progression of disease(PD) in 2 cases.The group of P53- negative patients(n=32) showed CR in 11 cases,PR in 20 cases,SD in 1 case, none of PD case.The efficacy of P53- negative patients was significantly better than that of P53-positive patients(P<0.05).Conclusion　The over-expression of P53 gene may influence the sensitivity of tumor cells to radiotherapy and chemotherapy.Therefore, detecting the expression of P53 gene may help to determine the response of esophageal carcinoma to the radiotherapy and chemotherapy， and to determine the prognosis of patients. It has a value for clinical cancer therapy.]]> 2017/12/18 8:27:00 JIANG Zhou, HUANG Jiang-qiong, XU Yang, et al. 326true ［Abstract］　Objective　To study the distribution and drug resistance of Gram-negative bacilli in patients with chronic obstructive pulmonary disease(COPD) complicated with hospital-acquired pneumonia(HAP), and to provide the evidences for clinical diagnosis and treatment.Methods　The bacteria were isolated from the specimens in the respiratory tract in 68 patients with COPD complicated with HAP from January 2009 to September 2014, and their drug susceptibilities were tested. The distribution and drug resistance of Gram-negative bacilli in the isolated specimens were retrospective analysed.Methods　One hundred and forty-seven strains of gram-negative bacilli were isolated from 68 patients, including 92 strains of Acinetobacter baumannii(62.6%), 32 strains of Pseudomonas aeruginosa(21.8%), 10 strains of Klebsiella pneumonia(6.8%), and 13 strains of other gram-negative bacilli(8.8%). The drug resistance rates of Acinetobacter baumannii to levofloxacin, ceftazidime, cefepime, imipenem, piperacillin/tazobactam and cefoperazone/sulbactam were 73.9%, 94.6%, 81.5%, 65.2%, 62.0% and 55.4%, respectively. The resistance rates of Klebsiella pneumonia to piperacillin, cefuroxime and ciprofloxacin were 50.0%, 60.0% and 90.0% respectively. The resistance rates of Pseudomonas aeruginosa to the above common antibiotics were lower.Conclusion　The common Gram-negative bacilli isolated from the patients with COPD complicated with HAP are Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia in which Acinetobacter baumannii is a multidrug-resistant pathogen. Clinicians should pay more attention to the prevention and treatment of infection caused by Acinetobacter baumannii in patients and use antibiotics properly.]]> 2017/9/12 9:14:26 LIANG Da-hua, WEI Cai-zhou, LIU Hang, et al. 325true ［Abstract］　Objective　To investigate the expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma and to analyze their relationship with biological characteristics of malignant, clinical stage, pathological grade and invasion and metastasis of ESCC and clinical significances.Methods　The expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma tissues and their para-cancerous tissues were detected by immunohistochemical SP method.Methods　The positive rates of CDC2 in esophageal squamous cell carcinoma, para-cancerous tissues were 80.00%, 50.00%(P<0.05), the differences were statistically significant; the positive rates of PFTK1 in esophageal squamous cell carcinoma, para-cancerous tissues were 53.33%, 30.00%(P<0.05), the differences were statistically significant. The expressions of CDC2 and PFTK1 were associated with TNM stage, invasive depth and lymph node metastasis(P<0.05). There was positive correlation between the expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma(r=0.367, P=0.004).Conclusion　CDC2 and PFTK1 may be involved in the occurrence and development of esophageal squamous carcinom.]]> 2017/9/12 9:14:26 SUN Jiang-tao, CHU Xu, CHEN Jian-min, et al. 324true ［Abstract］　Objective　To study the relationship between the types of polycystic ovarian syndrome(PCOS) and the heart rate turbulence(HRT).Methods　One hundred and twenty subjects were taken as controls and 158 patients with PCOS were investgated. The PCOS group was divided into two subgroups, with 102 patients in the obesity subgroup and 56 patients in the non-obesity subgroup. The Holter was done and turbulence onset(TO) and turbulence slope(TS) were observed and analyzed.Methods　Compared with the control group, TO in the obesity subgroup and the non-obesity subgroup distinctly increased, while TS and SDNN obviously decreased(P<0.05). Compared with the non-obesity subgroup, TO in the obesity subgroup distinctly increased, while TS and SDNN obviously decreased(P<0.05).Conclusion　HRT has a significance in evaluating the cardiovascular complications of PCOS.]]> 2017/9/12 9:14:26 CHEN Jing 323true ［Abstract］　Objective　To investigate the association between the expression of B-cell specific moloney leukemia virus insertion site 1(Bmi-1) and non-small cell lung cancer(NSCLC).Methods　According to the inclusion and exclusion criteria, We independently searched the case-control studies of Bmi-1 and non-small cell lung cancer that published in Pubmed, Embase, Web of Science, CNKI, Wanfang database and VIP database both in Chinese and English until March 2015, and a retrospective review of the literatures was analyzed. We extracted the clinic pathological features of NSCLC relevant to Bmi-1, such as gender, age and histological type. All statistical analysis was performed by the RevMan5.2 Meta-analysis software.Methods　Eleven case-control studies were eventually recruited, including 697 cases of NSCLC patients and 504 cases of the control group. Meta-analysis indicated that the expression level of Bmi-1 in NSCLC was significantly higher than that in the control group(P<0.01). The expression level of Bmi-1 in NSCLC was closely correlated with the degree of differentiation and the lymph node metastasis(P<0.01), but not correlated with the pathological types(P>0.05).Conclusion　The detection of Bmi-1 expression level may become a new method for the earlier diagnosis, prognosis and monitoring curative effects of NSCLC.]]> 2017/9/12 9:14:26 LAI Xiang-li, FENG Guo-sheng, GAO Shan 322true ［Abstract］　Objective　To investigate the effect of Dahuangzhechong capsule on matrix metalloproteinase-2(MMP-2) activity in rats with hepatic fibrosis.Methods　The collagen deposition and MMP-2 activity in the liver tissues were detected by Sirius red staining and zymography respectively.Results　With the severity of liver fibrosis, the rising of MMP-2 activity in Dahuangzhechong capsule group was significantly lower than that in the liver fibrosis model group(P<0.05), but greater than that in the control group(P<0.05).Conclusion　Dahuangzhechong capsule has a depressant effect on MMP-2 activity and inhibits the development of hepatic fibrosis in rats.]]> 2017/9/13 9:54:48 GUO Shan-shan, FAN Xiu-fang, WANG He-xiang, et al. 321true ［Abstract］　Objective　To explore the effect of laparoscopic drainage and windowing cyst puncture drainage joint hardener on hepatic cyst.Methods　Sixty patients with hepatic cyst were retrospectively studied from May 2010 to February 2014,and were divided into liver cyst puncture drainage joint hardener group(n=30),and laparoscopic fenestration of liver cyst lead group(n=30).The curative effect of the two groups were compared with a postoperative follow-up of 1 year.Results　The operation time,postoperative bed time and the length of hospital stay were less in the laparoscopic group than those in the other group(P<0.05).The postoperative drainage time of tube placement and the incidence of complications were not significantly different between the two groups(P>0.05).Conclusion　The treatment of hepatic cysts should be individualized and the appropriate treatment should be selected according to the different types of patients and situations.]]> 2017/9/13 9:54:48 ZHANG Zhuo, CAO Zi-long, HU Jian-li, et al. 320true ［Abstract］　Objective　To study the high risk factors of serious oral mucositis caused by radiotherapy for the patients with nasopharyngeal carcinoma(NPC）, and to seek for the early treatment and prevention of serious oral mucositis, and to establish a predictive model of prognostic index(PI) for physicians to give individualized treatment.Methods　The clinical factors of 221 NPC patients with oral mucositis were analyzed by univariate analysis and multifactorial COX regression. PI equation was built on basis of the COX regression mode1. According to PI values, the patients were classified into 2 different risk groups. The incidence rate of serious oral mucositis was compared between the two groups.Results　Multifactorial COX regression showed that chemotherapy, bad oral cavity and conventions radiotherapy were the high risk factors of serious oral mucositis. There was significant difference in the incidence rate of serious oral mucositis between the two groups classified by PI values(P<0.01).Conclusion　Chemotherapy, bad oral cavity and conventions radiotherapy are high risk factors of serious oral mucositis after radiotherapy for NPC. Early treatment and preventive actions have some preventive effects on it. PI values may be useful in predicting serious oral mucositis caused by radiotherapy for NPC and provide the valuable information for physicians to give individualized treatment.]]> 2017/9/13 9:54:48 PENG Lu-xing, CHEN Jia-xin, LU He-ming, et al. 319true ［Abstract］　Objective　To observe the effects of 3% hypertonic saline combined with ribavirin atomization inhalation in the treatment of upper respiratory tract infection.Methods　163 patients with upper respiratory tract infection were randomly divided into three groups, with 57 cases in group A, 53 cases in group B and 53 cases in group C.On basis of the conventional treatment in the three groups, Group A was treated with ultrasonic atomization inhalation of 0.9% saline 10 ml+Gentamicin 80 000 units+5 mg dexamethasone; Group B was treated with ultrasonic atomization inhalation of 3% hypertonic saline 10 ml+ribavirin 0.1 g+5 mg dexamethasone; Group C was with 3% hypertonic saline 10 ml+ribavirin 0.1 g+5 mg dexamethasone ultrasonic atomizing inhalation on the basis of the conventional treatment, all of the three groups were treated two times a day, four days for a course of treatment. The efficacy and sore throat, itchy throat, hoarseness and cough relief time and adverse reaction were compared among the three groups.Results　Sore throat, itchy throat, hoarseness and cough relief were improved better in group C than those in group A. Pharyngeal itching relieving time was shorter in group C than that in group B. No adverse reactions occurred except that one case in group A experienced asthmatic symptoms after using gentamicin aerosol because of allergic reaction.Conclusion　3% hypertonic saline combined with ribavirin ultrasound atomization inhalation is effective and safe in the treatment of upper respiratory tract infection. It can improve clinical symptoms and shorten the course of disease.]]> 2017/9/13 9:54:48 TENG Xiao-ming, GAO Xiu-juan, LIU Qiang, et al. 318true ［Abstract］　Objective　To compare and analyze the therapeutic results of humeral supracondylar fracture by two kinds of operative approaches.Methods　Sixty cases with humeral supracondylar fracture were operated by using posterior approach(Group A, n=30) and by using lateral approach(Group B, n=30 ). The exposure time, the closing time and the operation time were recorded and the function recovery was evaluated according to Flynn joint elbow function system.Results　The exposure time was （14.48±1.33）min in group A and （10.27±1.28）min in group B; The closed time was （20.60±1.83）min in group A and （17.00±1.36）min in group B; The operation time was （80.27±3.16）min in group A and （67.50±2.10）min in group B. The exposure time, the closing time and the operation time were shorter in group B than those in group A. 73.3% patients showed excellent or good results in the function of elbow joints in group A and 93.3% in group B, with a significant difference between the two groups（P<0.05）.Conclusion　It is a practical approach to use open reduction and internal fixation with kirschner pin for patients with Gartland Ⅲ humeral supracondylar fracture who are difficult in performing manipulative reduction. The effect of the surgery by lateral apporach is better than that by posterior approach for children with humeral supracondylar fracture.]]> 2017/9/15 8:39:15 LI Fu-lin, YIN Dong, MO Bing-feng, et al. 317true ［Abstract］　Objective　To analyze MRI features of the rotator cuff injury and to evaluate their clinical values in diagnosis of the rotator cuff injury.Methods　MRI data of 36 cases with rotator cuff injury were retrospectively analyzed and compared with the outcomes of open surgery or arthroscopy.Results　In all 36 patients, rotator cuff injury was showed on MRI images, with complete tear in 11 cases and partial tear in 25 cases. The accuracy rate was 81.8% in complete tears and 80.0% in partial tears.Conclusion　MRI can accurately diagnose rotator cuff injury and provide the information for clinical treatment.]]> 2017/9/15 8:39:15 ZHOU Shan, HUANG Wen-liang, WANG Bin 316true ［Abstract］　Objective　To explore the safety of two kinds of mild hypothermia in the treatment of acute severe brain injury.Methods　Thirty patients were randomly divided into group A(treated with surface cooling) and group B(treated with endovascular hypothermia). The time to reach target cooling temperature, the incidence of 1 ℃ deviated from the target temperature hypotension rate, heart arrhythmia rate and electrolyte disorder rate and other complications were compared between the two groups.Results　There were significant differences in the target cooling temperature time and the incidence of 1 ℃ deviated from the target temperature between the two groups(P<0.05). There were no significant differences in hypotension rate,heart arrhythmia rate, electrolyte disorder rate and other complications between the two groups(P>0.05).Conclusion　Endovascular cooling is a safe and efficient treatment method for quickly maintaining the target temperature with features of simplicity, stability and less complications.]]> 2017/9/15 8:39:15 LIU Jun, CAO De-chen 315true ［Abstract］　Objective　To evaluate the effect of hyperbaric oxygen on the wound healing after diabetic foot amputation surgery.Methods　Sixty patients receiving diabetic foot amputation surgery were divided into group A and group B by using the random number table, with 30 cases in each group. Conventional treatments were done in group A, including blood glucose control, wound dressing, infection control, etc. The same treatments plus hyperbaric oxygen therapy were done in group B for 1 week. The wound healing situation, complications and blood glucose control were compared between the two groups.Results　The basic situation of preoperation in the two groups had no significant difference(P>0.05). The levels of amputation in the two groups had no significant difference（P>0.05）. The wound healing of group B was better than that of group A(P<0.05) and the incidence of complications in group A was higher than that in group B(P<0.05). The control of blood glucose in group B is better than that in group A(P<0.01).Conclusion　Hyperbaric oxygen treatment is helpful for the healing of diabetic foot amputation surgery wound. It reduces complications and helps to control blood glucose.]]> 2017/9/15 8:39:15 YU Shao-lin, LI Hong-yu, JIN Xian-yue, et al. 314true ［Abstract］　Objective　To analyze the clinical manifestations and pathologic characters of nephrotic syndrome in elderly patients.Methods　We collected 41 nephrotic syndrome patients who were more than 60 years old in our hospital from January 2009 to January 2014 and analyzed their clinical manifestations and pathologic characters.Results　All of the 41 cases with nephrotic syndrome were diagnosed by renal biopsy, with 28 cases in primary glomerular disease(68.29%), in which membranous nephropathy was the most common pathological type, followed by focal segmental glomerular sclerosis and minimal change disease, and with 13 cases in secondary nephrotic syndrome(31.71%). Except for nephrotic syndrome, hematuria was found in 25 cases(60.98%), hypertension in 24 cases(58.54%), renal dysfunction in 20 cases(48.78%). Infection was the major complication(26.83%). No serious complications were found after the renal biopsy.Conclusion　The most common disease in the elderly patients with nephrotic syndrome is primary glomerular disease, in which membranous nephropathy is the most common pathological type. Major clinical manifestations are edema, hematuria, high blood pressure and high incidence of renal function impairment. Infection is the major complication. Renal biopsy is safe to apply in the elderly patients with nephrotic syndrome.]]> 2017/9/15 8:39:15 LIU Xiao-cong, SHAO Si-nan, ZHANG Yan-lin 313true ［Abstract］　Objective　To investigate the levels of serum cystatin C(CysC), B-type brain natriuretic peptide(BNP) and their clinical significances in the patients with acute myocardial infarction(AMI).Methods　Sixty patients with AMI were selected as the observation group, including 30 cases with ST segment elevation myocardial infarction(STEMI) as STEMI subgroup, and the other 30 cases with non ST segment elevation myocardial infarction(NSTEMI) as NSTEMI subgroup. 60 healthy cases were taken as the control group. The levels of BNP and CysC were determined and compared.Results　 The levels of serum CysC in the patients with AMI was significantly lower than those in the control group(P<0.01). The level of BNP in the observation group was significantly higher than that in the control group(P<0.01). The levels of CysC and BNP in STEMI subgroup were slightly higher than those in NSTEMI subgroup without differences between the two subgroups(P>0.05). There was no significant correlation between CysC and BNP(r=0.11, P>0.05).Conclusion　The levels of serum CysC and BNP are closely related to AMI. Detection of the concentration of serum CysC and BNP is clinically significant for the treatment of AMI.]]> 2017/7/13 10:28:25 MENG Zhao-na, LI Bao-yin, WANG Yao-xin, et al. 312true ［Abstract］　Objective　To study the risk factors of progressive ischemic stroke.Methods　The clinical data of 192 cases with ischemic stroke from January 2014 to February 2015 including 62 progressive patients(the observation group) and 130 nonprogressive ischemic stroke patients(the control group) were retrospectively analyzed. Nineteen factors including demographic data, case history, neurological deficits score and intracranial artery stenosis were analyzed. Logistic regression analysis was used.Results　Logistic regression indicated that the factors of the model sorted in descending order by OR values were cerebral infarction(OR=13.093), TIA medical record(OR=12.556), intracranial artery stenosis(OR=5.684), blood pressure dropping too low or too fast(OR=3.141), high fibrinogen(OR=2.867) and diabetes mellitus(OR=1.954).Conclusion　The risk factors of progressive ischemic stroke are cerebral infarction, TIA medical record, intracranial artery stenosis, blood pressure dropping too low or too fast, high fibrinogen and diabetes mellitus.]]> 2017/7/13 10:28:25 LIU Guo-jiang, WU Xue-liang, FANG Hong-ming 311true ［Abstract］　Objective　To observe the effects of carbon dioxide retention on the quality of recovery period of patients after laparoscopic colorectal surgery.Methods　Two hundred patients undergoing laparoscopic colorectal surgery under general anesthesia, ASAⅠ～Ⅱ, were randomly divided into two groups, with 100 cases in each group. Group A received laparoscopic colorectal resection surgery, and group B received abdominal colorectal resection surgery. PaCO₂ values were recorded at the time of extubation(T₁), 30 min (T₂), 1 hour (T₃), 2 hours (T₄), 24 hours (T₅) and 48 hours (T₆) after the extubation. Steward scores and the scores of the patients′ cooperation were assessed at the time points from T₂ to T₆. The extubation time, awake time, time of staying in the anesthesia recovery room and the complications that were related to hypercapnia after extubation were compared between the two groups.Results　PaCO₂ values at T_2～5 in both of the two groups were increased compared with that at T₁, and PaCO₂ values of group A at T_2～5 were significantly higher than those of group B(P<0.05). The patients′ cooperation scores of group B at T₂ were significantly increased than those of group A(P<0.05). There were no significant differences in the awake time and extubation time between the two groups(P>0.05). The time of staying in the anesthesia recovery room in group A was significantly longer than that in group B(P<0.01). The incidences of hypertension, nausea, vomiting, restlessness in group A were significantly higher than those in group B(P<0.05).Conclusion　The patients receiving laparoscopic colorectal surgery absorb the postoperative residual CO₂ in their abdomens, which affects the patients′ anesthesia duration, awake time and the quality of anesthesia, and increases the incidence of complications during anesthesia recovery.]]> 2017/7/13 10:28:25 RAN Xue-lian, CHEN Jun 310true ［Abstract］　Objective　To investigate the relationship between the initial symptoms of amniotic fluid embolism(AFE) and the maternal outcomes.Methods　The initial symptoms in 20 cases with AFE and their maternal outcomes in our hospital from January 2000 to August 2014 were retrospectively analyzed.Results　Disseminated intravascular coagulation(DIC) was the initial symptom in 12 cases, in which 3 cases died, and seizure in 5 cases, in which 2 cases died. One case fell in coma initially and died, 2 cases died soon after getting cardiac arrest as the initial symptoms.Conclusion　Compared with those patients with DIC as the initial symptom, the patients with cardiac arrest, coma, or seizures as the initial symptoms caused by AFM are more likely to get a fatal outcome and a poor prognosis.]]> 2017/7/13 10:28:25 QIN Ting,TIAN Mao 309true ［Abstract］　Objective　To investigate the awareness status of relevant knowledge about electrocardiogram(ECG) and the skill training effect on the medical workers in urban communities and to explore the countermeasures for the improvement of teaching quality.Methods　Eighty-three medical workers from the urban communities with middle-level professional titles in 18 cases and primary-level titles in 65 cases. All the community medical workers were investigated with a self-designed questionnaire. The centralized training ECG theory and practice was performed in all the cases. The training results were compared before and after the training.Results　Before the training:(1) the awareness rates of normal ECG and AMI ECG were 43.1%～44.6% and 44.6%～90.8% respectively in the medical workers with primary-level professional titles, and 16.7%～66.7% and 22.2%～100.0% respectively in the medical workers with middle-level professional titles;(2)the rates of proper analysis of ECG and proper operation of ECG were 26.2% and 58.5% in the medical workers with primary-level professional titles, and 38.9% and 83.3% respectively in the medical workers with middle-level professional titles. After the training:(1)the awareness rates of normal ECG were 70.8%～84.6% and 88.9%～94.4% in the medical workers with primary-level and in those with middle-level professional titles respectively; the awareness rates of AMI ECG was 50.8%～98.5% and 27.8%～100.0% in the medical workers with primary and middle-level professional titles respectively.(2)the correct rates of reading ECG and operating ECG were 49.2% and 55.6%, 75.4% and 94.4% in the medical workers with primary and middle-level professional titles respectively. With a significant difference before and after the treatment(P<0.05).Conclusion　It is necessary to improve the ECG knowledge and the operation of ECG for community medical workers, and training of ECG skill training can help them improve the pre-hospital diagnosis of AMI.]]> 2017/7/13 10:29:15 ZHANG Qin, YANG Su-ping, ZHANG Ya-li, et al. 308true ［Abstract］　Objective　To explore a method of reducing the complications of inguinal seroma after the surgery of inguinal hernia repair.Methods　Retrospective analysis was made on the clinical data of 20 cases who were treated by laparoscopically inguinal hernia repair with high site ligation of hernial sac.Results　All the operations were performed successfully on the patients. Seroma and hydrocele of tunica vaginalis were not found with a follow-up of 1 to 4 months.Conclusion　High site ligation of hernial sac in laparoscopically inguinal hernia repair may be a good way to reduce the complications of seroma after inguinal hernia repair. However more data and a longer following-up are needed to prove its feasibility, safety and effectiveness.]]> 2017/7/13 10:29:15 XU Wei, FENG Ze-rong, QIN Xi-cheng, et al. 307true ［Abstract］　Objective　To investigate the detectable rate and the clinical characteristics of depressive disorders in the inpatients with malignant tumors.Methods　A total of 413 cancer inpatients were recruited from the department of oncology and were surveyed with a Chinese version of the Mini International Neuropsychiatric Interview and TCSQ by two trained psychiatrists. The patients′ socio-demographic and clinical data were collected during the interview. All the data were analysed in the end.Results　The detectable rate of depressive disorders in inpatients with malignant tumors was 22.0%; Unmarried state, distant metastasis of cancers, a duration of time≤1.5 years before the diagnosis of cancer, receiving palliative care, and having breast cancer were the high risk factors of depression.Conclusion　The inpatients in the department of oncology have a high detectiable rate of depressive disorders. Oncologists should pay more attention to the mental health problems of patients with cancerous tumors, especially with negative cognitive and cognition.]]> 2017/7/13 10:29:15 ZONG Ling, JING Ju-zhen, QU Hong-ru, et al. 306true ［Abstract］　Objective　To investigate the efficacy and safety of intermittent total hepatic inflow occlusion with low central venous pressure in hepatectomy.Methods　Sixty patients with hepatocellular carcinoma who underwent hepatectomy from January 2011 to March 2013 were randomly divided into the research group(treated with the intermittent total hepatic inflow occlusion with low central venous pressure) and the control group(treated with selective hemihepatic blood flow occlusion), with 30 cases in each group. The general conditions before the operation, the average operation time, total bleeding volume, blood transfusion, postoperative hepatic and renal function changes were compared between the two groups.Results　There were no significant differences between the two groups in the general conditions before the operation, time of vascular clamping, total bleeding volume, area of liver transection plan, weight of resected liver tissues and the amount of blood transfusion（P>0.05）. The average operation time of the research group［(207.15±49.27)min］ was significantly shorter than that of the control group［(254.03±58.70)min］（P<0.01）. The levels of TBIL and ALT in the research group were significantly higher on the first and the third day after the operation than those in the control group(P<0.05). There were no significant differences in the incidences of the complication between the two groups（P>0.05）.Conclusion　Intermittent total hepatic inflow occlusion with low central venous pressure is a simple, safe and effective method for hepatectomy, which can reduce bleeding and lessen hepatic ischemia-reperfusion injury.]]> 2017/7/13 10:29:15 LONG Di, LI Bi-wan, BI Yong-hao, et al. 305true ［Abstract］　Objective　To explore the application value of MRI in the prenatal diagnosis of placenta implantation.Methods　One hundred pregnant women with high risk factors of placenta implantation were studied, all of whom underwent routine pelvic MRI examination. The MRI examination results were compared with the surgical and pathological results.Results　The sensitivity and specificity of MRI were 84.38% and 83.33% respectively, and the positive predictive value and negative predictive value were 90.00% and 75.00% respectively. The MRI features were low signal band in T2WI, uneven signal in the placenta, the lower part of the uterus and placenta tissue invasion of uterine muscular layer.Conclusion　The application of MRI in the prenatal diagnosis of placenta implantation is of high accuracy with a low rate of missed diagnosis.]]> 2017/7/13 10:29:15 LI Yu-zhe, YANG Hong, WANG Chen-hong 304true ［Abstract］　Objective　To observe the effect of Bushenjiangu decotion on bone mineral density and biomechanical properties in osteoporotic rats caused by ovariectomy.Methods　Ninety female Wistar rats［aged 6 months, (300±20)g］ were randomly divided into the blank control group(n=15), the model control group(n=15), Bushenjiangu decotion high dose group(n=15), Bushenjiangu decotion middle dose group(n=15), Bushenjiangu decotion low dose group(n=15) and estrogen group(n=15). Except for the blank control group, all groups were made into animal models of osteoporosis. After 3 months of administration, all animals were sacrificed and sampled.Results　(1)Compared with those in the normal group, the bone mineral density and bone mineral content in osteoporotic rats in the other groups decreased significantly(P<0.05). Compared with those in the model control group, the bone mineral density and bone mineral content in Bushenjiangu middle and high dose group and estrogen group increased significantly(P<0.05); there was no significant difference between Bushenjiangu decotion in high dose group and estrogen group; (2)The rats ′femur of maximum load and elastic modulus and yield strength were significantly decreased in Bushenjiangu decotion low, middle and high groups than those in the model control group(P<0.05); there were no significant differences beween the blank group and Bushenjiangu decotion groups(P>0.05).Conclusion　Bone mineral density and bone mineral content are decreased significantly in ovariectomized rats; Bushenjiangu decotion elevates the bone mineral density and bone mineral content and obviously improves the biomechanical properties of bone in the ovariectomized rats.]]> 2017/8/4 9:07:51 ZHANG Dong-peng, ZHANG Ding-hua 303true ［Abstract］　Objective　To investigate the clinical outcomes of double locking compression plate and Y shape plate in the treatment of type C humeral intercondylar fractures.Methods　Forty-six patients with type C humeral intercondylar fractures from February 2009 to March 2013, were included in this study. Twenty-eight cases were taken as double locking compression group, and 18 cases were taken as Y shape plate group according to the different surgical methods. Both of the two groups used the same surgical approach during which the deltoid muscle behind elbow was split. The clinical outcomes were assessed by Mayo Elbow Scores and the data were analyzed by SPSS19.0.Results　The excellent and good rate of double locking compression group(85.7%) was significantly elevated than that of Y shape plate group(50.0%) after a follow-up period of 15～42 months with an average of 24.3 months.Conclusion　Double locking compression plate is better than Y shape plate in the treatment of type C humeral intercondylar fractures.]]> 2017/8/4 9:07:51 HUANG Chong-you, CHEN Wan, CHEN Wei-min, et al. 302true ［Abstract］　Objective　To analyze the incidence trend and treatment of pertussis syndrome in Qingdao city from 2012 to 2014.Methods　A retrospective study was performed on 82 infants with pertussis syndrome who was hospitalized in the department of respiratory in Women and Children′s Hospital of Qingdao from January 2012 to December 2014.Results　(1)Pertussis syndrome was characterizd by age, season and residence. The age ranged from 2 months to 22 months, and the most patients were younger than 6 months. The total 82 patients were constituted by 37 males(45.12%) and 45 females(54.88%). Of the 82 patients, 70 cases(85.37%) were hospitalized in spring and summer, and the rest of 12 cases(14.63%) were hospitalized in autumn and winter, 29 cases(35.37%) came from city area, the other 53 cases(64.63%) from rural places. (2)More diverse etiologies were fund in the patients in 2014. Of the 82 patients, 11 cases were infected by mycoplasma pneumoniae, 5 cases by adenovirus, 1 case by baumanii, 3 cases by enterobacter cloacae and 6 cases uninfected. Single pathogen infection was found in 40 cases. Infections by two kinds of pathogens were found in 7 cases, and three kinds of pathogens were found in 3 cases. Bordetella pertussis couldn′t be found in all cases. (3)The imaging findings were more complicated in patients in 2014. Bronchial pneumonia, interstitial change, atelectasis and gastroesophageal reflux were more common in 2014 than in 2012 and 2013. (4)More complicated conjunctival hemorrhage and wheeze were found in the patients in 2014 and they need a combination of many kinds of antibiotics and their average hospital stay was longer.Conclusion　Pertussis syndrome has obvious seasonal characters to occur, and the incidence trend is increased year by year. The etiology and complications are more complicated, which leads to a difficult treatment and a combination of antibiotics.]]> 2017/8/4 9:07:51 WANG Li-yan, WANG Wen-di, FAN Wen-wen, et al. 301true ［Abstract］　Objective　To explore the technical points and clinical effects of total hip replacement in the treatment of ankylosing spondylitis and hip joint stiffness.Methods　Total hip arthroplasty was performed in 17 patients(32 hips) with ankylosing spondylitis and hip joint stiffness from March 2011 to March 2014. The mean follow-up was 25.4 months(from 13 months to 35 months). The improvement of knee joint pain, joint flexion deformity correction, joint activity score and Harris score were compared before and after the surgery, and at the end of the follow-up.Results　The average flexion contracture deformities of the hips in 14 patients(27 hips) were （35.42±3.15）° and （4.63±2.12）° before and after the surgery respectively with a significant difference(P<0.01). The average total ranges of motions(including flexion, extension, pronation, abduction, adduction and external rotation) were （5.81±3.32）° and （152.47±3.76）° before and after the surgery respectively with a significant difference(P<0.01). The average Harris scores were （27.73±6.41） and （82.31±6.58） before and after the surgery respectively with a significant difference(P<0.01). Severe pain was found in 3 cases, moderate pain in 6 cases, mild pain in 8 cases before the surgery and mild postoperative pain in 7 cases, no case with severe pain after the surgery. No fracture, infection and sciatic nerve injury occurred.Conclusion　Total hip replacement can quickly relieve pain, improve joint function and make the patients regain the ability to take care of themselves in the treatment of ankylosing spondylitis and hip joint stiffness.]]> 2017/8/4 9:07:51 WANG Jun, HUANG Jian, GUO Wei-kang 300true ［Abstract］　Objective　To summarise the surgical treatment experience of Bentall procedure in municipal hospitals in Liuzhou and to explore the influencing factors on the early efficacy of Bentall procedure.Methods　The clinical data were retrospectively analyzed in 28 patients who underwent the Bentall procedures from January 2005 to December 2014 in municipal hospitals in Liuzhou.Results　During the early stage after Bentall procedure, 3 cases died of multiple systems organ failure from pulmonary infections and respiratory insufficiency, 2 cases died of lower cardiac output symptom, 1 case died of chronic heart failure. The total mortality in early stage after Bentall procedure was 21.43%, among which pulmonary infections and respiratory insufficiency were the major complications. During the follow-up period, 1 case died of lung cancer, 1 case suffered from large area cerebral infarction and the rest had a significant improvement of cardiac function after Bentall procedure.Conclusion　Bentall procedure provides optimal survival for the patients in municipal hospitals in Liuzhou. The relatively higher early mortality may be related to the acute aortic dissection. Improving the surgical skills, reducing the extracorporeal circulation duration, especially after aorta block, and actively preventing the complications after surgery are the key steps to improve the clinical outcomes.]]> 2017/8/8 16:30:41 XIANG Min-feng, LIU Yong-chun, WEI Fu-wang, et al. 299true ［Abstract］　Objective　To investigate the effect of amiodarone on the recurrence of paroxysmal atrial fibrillation(PAF) after radiofrequency catheter ablation.Methods　Eighty-four patients with PAF who were collected in our hospital from July 2012 to December 2014, and were divided into the treatment group and the control group, with 42 cases in each group. The control group didn′t receive antiarrhythmic drugs after ablation, while the treatment group was treated with amiodarone after ablation. The postoperative early recurrence and late recurrence, and the postoperative left atrial diameter(LAD) and left ventricular ejection fraction(LVEF) were compared between the two groups.Results　The heart rate of the treatment group［61～ 89(69.3± 3.1)beats/min］ was significantly lower than that of the control group［68～108(77.8±4.5)beats/min］ after the follow-up of three months(P<0.01). The early recurrence rate and the late recurrence rate in the treatment group were significantly lower than those in the control group(P<0.05). At 3 and 12 months after the operation, LAD in the treatment group was significantly less than that in the control group, and the LVEF level was significantly higher in the treatment group than that in the control group(P<0.05).Conclusion　Amiodarone can prevent AF recurrence, reverse left atrial structural and electrical remodeling activity, and improve the heart function in PAF patients after radiofrequency catheter ablation.]]> 2017/8/8 16:30:41 ZHAO Yu-jie 298true ［Abstract］　Objective　To investigate the diagnostic value of poor R-wave progression(PRWP) in patients with anterior acute myocardial infarction(AMI).Methods　Forty-eight patients with chest pain and PRWP were recruited in this study. According to the 12-lead electrocardiogram(ECG), 23 patients with the dynamic changes of PRWP were collected as group A, and the other 25 patients without the dynamic changes of PRWP as group B. The clinical characteristics, laboratory examination, 12-lead ECG, cardiac troponin I(cTNI), ultrasonic cardiogram(UCG) and coronary angiography(CAG) were analyzed in the two groups, and their positive predictive values in anterior AMI were compared.Results　The positive predictive value in the diagnosis of anterior AMI was 34.78% in group A, and 20.00% in group B, P<0.05.Conclusion　The dynamic changes of PRWP are still an useful diagnostic clue for anterior AMI patients.]]> 2017/8/8 16:30:41 WU Xing-an, LI Xiu-qi, XIE Gang, et al. 297true ［Abstract］　Objective　To explore the expression and significance of Pre-B cell colony enhancing factor(PBEF) in the lungs of newborn rats with hyperoxia-induced bronchopulmonary dysplasia(BPD).Methods　Forty-eight full-term newborn Sprague- Dawley rats were randomly divided into the experimental group(hyperoxia, n=24) and the control group(room air, n=24) according to the fraction of inspiratory（FiO₂） within 12 hours after birth. The rats of experimental group stayed in the space of 800 ml·L^-1 oxygen, while the rats of the control group were exposed to room air. On the 3th,7th,14th day of the experiment, 8 newborn rats in the experimental group and other 8 rats in the control group were randomly sacrificed after anesthesia. The sections of lungs were stained with HE method to assess lung histology changes and the lung radical alveolar counts(RAC) were examined. The location and semi-quantitative analysis of PBEF in lungs were detected by immunohistochemical method. The PBEF mRNA expression levels were detected by reverse transcription polymerase chain reaction(RT-PCR). The protein expression levels of PBEF in lungs and bronchoalveolar lavage fluid(BALF) were determined by Western blot and ELISA respectively.Results　（1）Stained by HE, the lungs the of experimental group showed destroy of alveoli, alveoli fusion and increased septal wall thickness. The radical alveolar counts were significantly lower in the experimental group than those in the control group(P<0.05). （2）PBEF protein expressed in alveolar epithelial cell, bronchial epithelial cells, pulmonary vascular endothelial cell and inflammatory cells predominantly. The IOD on the 3th and 7th day were significantly increased in the experimental group compared with those in the control group(P<0.05). （3） The PBEF mRNA expressions of PBEF on the 3th and 7th day were significantly increased in the experimental group compared with those in the control group and the protein expressions of PBEF were significantly increased in the experimental group compared with those in the control group(P<0. 05).Conclusion　PBEF is likely to play an active role during the developing of hyperoxia-induced BPD.]]> 2017/8/8 16:30:41 ZHENG Xue 296true ［Abstract］　Objective　To investigate the clinical effect of Doula combined with unprotected delivery on natural childbirth.Methods　Two hundred cases with full-term birth, single birth, natural head position and without high-risk gravid in the Maternal and Children′s Hospital of Wuming District from January 2014 to December 2014 were randomly divided into the observation group(treated with Doula delivery, n=100) and the control group(treated with traditional delivery, n=100). The bleeding volume, duration of delivery, cesarean section rate, episiotomy rate and the degree of satisfaction of the women were compared between the two groups.Results　There were significant differences between the observation group and the control group in the bleeding volume［(182.60±50.78)ml vs (255.00±114.83)ml］, in the average duration of labor［(5.36±1.48)h vs (9.06±1.02) h］, in the episiotomy rate（9% vs 33%）, in the cesarean section rate（15% vs 33%）, and in the degree of satisfaction（98% vs 83%）, P<0.01.Conclusion　Doula delivery effectively reduces the rate of cesarean section and increases the rate of vaginal delivery.]]> 2017/8/8 16:30:41 HUANG Dan-dan, YANG Ling-ling 295true ［Abstract］　Objective　To investigate possible myocardial damage in rotavirus enteritis.Methods　According to the rotavirus detection test, 131 children with diarrhea were divided into the observation group(rotavirus positive, n=62) and the control group(rotavirus negative, n=69). The severity of diarrhea, signs of cardiac damages, ECG/chest X-ray, the elevation of myocardial enzymes and troponin T were compared between the two groups.Results　There were no significant differences between the two groups in severity of diarrhea, signs of cardiac damage(P>0.05). There were more elevated CK and CK-MB in the observation group than those in the control group(P<0.05). There was only one case with weak positive troponin T in the observation group. ECG and chest X-ray examination did not show the specific changes of myocardial damage in the two groups.Conclusion　Myocardial damage is infrequent in rotavirus enteritis and there might be false positive results for the detection of CK-MB by immunosuppression.]]> 2017/8/10 9:01:20 WANG Zhi-jian, ZHU Mei-hua, WEN Hong-yan, et al. 294true ［Abstract］　Objective　To explore the correlation between the the levels of fibrinogen and troponin T and the severity of coronary artery stenosis.Methods　Five hundred patients were collected and were diagnosed with coronary heart diseases by coronary angiography, and the degree of coronary stenosis was evaluated by Gensini score. The levels of fibrinogen and troponin T were detected in all the patients. Single factor analysis was performed and the correlation between the levels of fibrinogen, troponin T and the degree of stenosis of coronary artery stenosis was analyzed.Results　With the increase of Gensini score, the levels of fibrinogen and troponin T increased gradually, and the correlation coefficient was 0.638(P<0.01).Conclusion　Both fibrinogen and troponin T are closely related to the degree of coronary stenosis. The combination of fibrinogen and troponin T is significant to evaluate the degree of coronary lesions.]]> 2017/8/10 9:01:20 WANG Yao-xin, MENG Zhao-na, LIU Jie-yun, et al. 293true ［Abstract］　Objective　To evaluate the application value of three-dimensional(3D) printing technique in the surgical treatment of complex tibial plateau fracture.Methods　Two cases with complex tibial plateau fractures of type SchatzkerⅥ were enrolled in this study. On preoperative spiral CT scanning, the data of lamellar CT scanning were imported into Mimics 14.0 software for 3D anatomical modeling, and then internal fixations were simulated based on all the printer models. The simulated operation was compared with the real operation in the surgical approach, the type of steel plate, the placement of steel plate, the length and number of screw.Results　Two cases fully adopted the planned fixed methods. The number of fixed steel plate, the number and length of screw in the real operation were accordance with those in the simulated operation. X-ray showed that the fractures were reached anatomical reattachment with internal fixation in the good position and fractures were reset satisfactorily.Conclusion　3D printing technology can help understanding complex fractures of tibial plateau and developing the preoperative planning, shortening the operation time and improving the operation efficiency in the treatment of complex tibial plateau fractures.]]> 2017/8/10 9:01:20 LIU Chao, XU Ya-fei, TANG Li-ying, et al. 292true ［Abstract］　Objective　To observe the application of the cervical dilation double-balloon catheter combined with artificialmembrane rupture and oxytocin in induction of labor at term.Methods　Ninety full-term pregnancy women with indications of induced abortion,and cervical Bishop scores ≤5 were collected and randomly divided into two groups.The cervical dilation double-balloon catheters were used to mature cervix. The observation group(n=45) was treated with artificial rupture of membrane and intravenous drop of oxytocin in induction of late pregnancy and spontaneous parturition was performed on the control group(n=45) after the balloons were withdrawn. The effect of induction and the outcome of newborn were compared between the two groups.Results　The cervical Bishop scores were elevated after the application of the cervical dilation double-balloon catheters(P<0.01). The success rates of abortion and vaginal delivery in the observation group were significantly higher than those in the control group(P<0.05). The childbirth process was significantly shorter in the observation group than that in the control group(P<0.01). There were no significant differences in postpartum blood loss, intrapartum fever, pelvic soft tissues rupture and asphyxia of the newborn between the two groups(P>0.05).Conclusion　Application of the cervical dilation double-balloon catheter combined with artificial rupture of membrane and oxytocin contribute to maturing cervix, shortening the childbirth process and increasing the vaginal delivery rate.]]> 2017/8/10 9:01:20 WANG Yan-li 291true ［Abstract］　Objective　To compare the curative effect between laparoscopic distal gastrectomy and open gastrectomy in patients with early gastric cancer.Methods　Seventy-two patients with early gastric cancer treated in our hospital from November 2013 to November 2014 were selected as the research subjects and were divided into the control group(n=36) and the observation group(n=36) by the random number table method. The control group was treated with open distal gastrectomy while the observation group was treated with laparoscopic distal gastrectomy. The operation time, length of incision, intraoperative bleeding volume, quantity of lymph node dissection, time of postoperative anal exhaust, time of off-bed activities, semiliquid recovery time, hospital stays and complications were compared between the two groups. The postoperative recurrence, cancer cell metastasis and survival rate were compared between the two groups after a follow-up of 12 months.Results　The operation time, length of incision and intraoperative bleeding volume［(168.8±30.9)min, (6.6±2.3)cm, (131.8±63.4)ml］ and time of postoperative anal exhaust, time of off-bed activities, semiliquid recovery time and hospital stays［(2.9±1.4), (2.4±0.9), (7.4±1.6), (10.7±3.6)d］ in the observation group were better than those in the control group(P<0.05); The incidence of postoperative complications in the observation group(8.3%) was significantly lower than that in the control group 27.6%(P<0.05). There were no local recurrence of tumor, cancer cell metastasis and death cases and the survival rate was 100.0% in the two groups after the follow-up.Conclusion　Laparoscopic distal gastrectomy has the same clinical effect as open surgery in the treatment of early gastric cancer, however, the operation time is shorter and the intraoperative bleeding volume is less in the patients with laparoscopic distal gastrectomy, which is beneficial for patients to recover from operation as soon as possible.]]> 2017/8/10 9:01:20 SUN Sheng-an, HAN Bao-wei, DONG Shuai-jun, et al. 290true ［Abstract］　Objective　To observe the clinical significance of early palliative care in previously untreated patients with advanced metastatic breast cancer.Methods　Fifty-three patients with metastatic breast cancer confirmed by pathology and imaging were collected from July 2011 to December 2014, and were randomly divided into two groups. The treatment group(n=27) received early palliative care and standard chemotherapy, while the control group(n=26) was treated with chemotherapy alone. The levels of Hospital Anxiety and Depression Scale(HADS) and the Patient Health Questionnaire(PHQ-9) were compared between the two groups before and after the treatment, and the overall survival was also observed.Results　HADS(D) and PHQ-9 scores in the treatment group were significantly lower than those in the control group(P<0.05). The median overall time of the treatment group(29.0 months) was significantly longer than that of the control group(23.5 months)(P<0.05).Conclusion　Early palliative care improves the quality of life in patients with metastatic breast cancer, and prolongs their overall survival.]]> 2017/8/10 9:01:20 SHAN Feng-xiao, REN Tie-jun 289true ［Abstract］　Objective　To explore the clinical characteristics，diagnosis and treatment of gastrointestinal stromal tumor（GIST）.Methods　The clinical data of 30 patients with GIST who were admitted between June 2004 and June 2014 were analyzed retrospectively.Results　In the 30 patients with GIST, the lesions were located in the stomach（14 cases）, duodenum（2 cases）, small intestine（10 cases）, colon（2 cases） and rectum（2 cases）. All the lesions were identified by imaging examination. All patients underwent complete resections, including multiple organs resection(2 cases) and endoscopic resection(3 cases). After the operation, the diagnosis was confirmed by pathological examination and immunohistochemistry. The results of immunohistochemistry demonstrated that tumor cells were positive for CD117 in 29 cases(96.7%), for CD34 in 22 cases(73.3%) and for DOG-1 in 28 cases(93.3%). Twenty-five patients were followed up postoperatively from 12 months to 10 years. During the follow-up period, 8 cases died, recurrence or metastasis occurred in 8 cases, and 9 cases remained in a stable condition.Conclusion　GIST shows untypical clinical features. Raising awareness of GIST, avoiding misdiagnosis, timely surgical resection and targeted therapy are the major measures for improving the prognosis of GIST.]]> 2017/8/10 17:32:15 HUANG Peng, WU He-shui 288true ［Abstract］　Objective　To investigate the effect of lifestyle and eating habits on irritable bowel syndrome(IBS).Methods　One hundred and five patients diagnosed as IBS by gastrointestinal endoscopy in our hospital from February 2015 to May 2015 and were collected as IBS group. Other 96 patients without IBS were collected as the control group. All the patients received the questionnaires designed by Rome Ⅲ diagnostic criteria to study the food habits and lifestyles related to IBS. The influencing factors of IBS were examined by the Logistic analysis.Results　Cold food(60.00%), spicy food(51.43%), rich food(37.14%), milk（28.57%), meat（20.00%）, drinking wine(20.00%）, tea（14.29%） and yogurt（14.29%) predisposed the patients to IBS. There were significant differences between the two groups in eating breakfast, fruits and vegetables, in smoking and daily consumption of drinking water(P<0.05). However, there was no significance difference in eating staple food between the two groups（P>0.05）. The protective factors of IBS included eating breakfast, fruits and vegetables, and drinking appropriate water every day. Smoking is the risk factor of IBS.Conclusion　A healthy lifestyle and proper diet are helpful for preventing the symptoms of IBS.]]> 2017/8/10 17:32:15 ZHENG Jie, DANG Tong 287true ［Abstract］　Objective　To explore the feasibility and safety of one-stage resection and anastomosis in the treatment of left colon cancer with intestinal obstruction.Methods　The clinical data of 43 patients with resection and anastomosis of left colon cancer and intestinal obstruction in our hospital from January 2000 to December 2014 were retrospectively analyzed.Results　All the patients were treated with one-stage resection and anastomosis, and intraoperative colonic lavage. Nine cases were performed routine preventive ileum colostomy. One case had postoperative anastomotic fistula but was cured after the treatment of unobstructed drainage and parenteral nutrition. Three cases had incision infection but were cured after wound dressing changes. Two cases had intestinal obstruction but were cured after the conservative treatment. No abdominal abscess,and no operative deaths occurred.Conclusion　It is safe and feasible to perform intraoperative colonic lavage and routine preventive ileum colostomy during the operation of one-stage resection and anastomosis for left colon cancer patients with intestinal obstruction.]]> 2017/8/10 17:32:15 LI Hui, LI Yun-fu, DENG Dong-hai, et al. 286true ［Abstract］　Objective　To study the effects of irbesartan, hydrochlorothiazide and amlodipine combined with metoprolol in the treatment of refractory hypertension.Methods　Eighty patients with refractory hypertension were divided into the observation group(n=40) and the control group(n=40) according to the principle of voluntary. The control group received the treatment of irbesartan, hydrochlorothiazide and amlodipine. The treatment in the observation group was the same as that in the control group except that metoprolol was added.Results　In the observation group, 35 cases were markedly effective; 5 cases effective; No cases ineffective. In the control group, 27 cases were effective; 9 cases effective; 4 cases ineffective. The clinical effect of the observation group was better than that of the control group(P<0.05). The incidence of adverse reactions in the observation group(0.00%) was significantly lower than that in the control group(30.00%)(P<0.01).Conclusion　Irbesartan in conjunction with hydrogen chlorine thiophene hydrochlorothiazide and amlodipine combined with metoprolol is safe and effective in the treatment of refractory hypertension.]]> 2017/8/10 17:32:15 GUO Yan-ge, ZHANG Ning, ZHAO Shao-hua, et al. 285true ［Abstract］　Objective　To investigate the efficacy of high-flux hemodialysis(HFHD) and hemodiafiltration(HDF) in the treatment of uremia.Methods　A retrospective analysis of 48 cases with uremia during February 2013 to August 2014 was conducted. The patients were randomly divided into two groups. The observation group(n=24) was treated with HPD and the control group(n=24) was treated with HDF for 80 days. Creatinine, urea nitrogen and serum leptin were tested before and after the treatment, and the levels of serum leptin in both of the two groups were compared with that in 20 healthy people.Results　There were no significant differences in the levels of creatinine, urea nitrogen and serum leptin between the control group and the observation group before the treatment. After the treatment, the levels of creatinine and urea nitrogen were significantly decreased in both of the observation group and the control group(P<0.05); but the level of serum leptin only decreased in the observation group(P<0.05).Conclusion　The level of serum leptin is significantly higher in the uremic patients than that in the healthy people. HFHD can effectively reduce the levels of serum leptin, creatinine and urea nitrogen in patients with uremia.]]> 2017/8/30 17:15:12 LEI Ming, ZHANG Hong 284true ［Abstract］　Objective　To study the effects of hemodialysis on the inflammation and coagulation change in the CKD5 patients.Methods　The CKD5 patients were chosen in the Affiliated Hospital of Luzhou Medical College from January 2013 to December 2014 and their coagulation and inflammatory markers were detected.Results　Compared with those in the control group(n=35), CKD5 of blood coagulation and inflammation in the CKD5 group(n=57) were significantly increased gradually with the decline in glomerular filtration. Fg was significantly increased and CRP significantly decreased in the dialysis CKD5 group(n=40) than those in the non-dialysis group(n=17)(P<0.05). Univariate correlation analysis showed that CRP was significantly positively correlated with Fg and D-D.Conclusion　CKD5 patients may have a hypercoagulable state and secondary fibrinolysis. Hemodialysis may aggravate these disorders. The hypercoagulable state in CKD5 patients is closely related to inflammation and CRP may be the risk factor.]]> 2017/8/30 17:15:12 WANG Yu-jie, HU Cheng-gang, PENG Su-ying, et al. 283true ［Abstract］　Objective　To evaluate the importance of combined detection of tumor markers CA125 and HE4 in the diagnosis of ovarian cancer.Methods　The digital literatures were retrieved from the databases of PubMed, CNKI and VIP to evaluate the significance of the combined detection of the tumor markers CA125 and HE4 in the diagnosis of ovarian cancer. Stata 12.0 software was used to conduct the Meta-analysis.Results　A total of 11 literatures were obtained in the current work with 834 ovarian cancer cases and 1 784 controls. The result showed that the sensitivity, specificity and diagnostic odds ratio(DOR) index of the tumor markers CA125 and HE4 were 0.89［95%CI（0.85,0.92）］, 0.13［95%CI（0.09,0.18）］ and 44［95%CI（28,71）］ respectively in the combined detection of tumor markers CA125 and HE4, while the indices of the sensitivity, specificity, diagnostic odds ratio(DOR) of the marker CA125 that was detected alone were 0.72［95%CI（0.65,0.78）］, 0.35 ［95%CI（0.27,0.46）］ and 10［95%CI（5,19）］ respectively. There were significant differences between the two methods in diagnosing ovarian cancer.Conclusion　The combined detection of the tumor markers CA125 and HE4 may provide more competent and valuable laboratory proofs for the clinical diagnosis of ovarian cancer than the detection of CA125 alone.]]> 2017/8/30 17:15:12 BAI Shan-shan, HE Ya-jun 282true ［Abstract］　Objective　To analyze the clinical effect of nano resin in the treatment of dental defects in the anterior teeth.Methods　One hundred and ninety-two patients with dental defects(anterior teeth) were collected from January 2010 to January 2015 and were randomly divided into the observation group and the control group, with 96 cases in each group. The dental defects of the observation group were repaired by the nano resin, and those of the control group were repaired by the conventional composite resin. The curative effects were compared between the two groups.Results　In the observation group, the filler mater of the defected teeth fell out in 1 case and pulpitis occurred in another case. The successful rate of the observation group(97.92%) was significantly higher than that of the control group(59.38%)(P<0.01).Conclusion　The nano resin aesthetic repair of dental defected teeth can restore the smooth surface of the defected teeth, form more complete, tighty-sealed and beautiful teeth, reduce the possibility of coloration, discoloration and fold crack of the repaired body, and reduce the occurrence of gingivitis and secondary caries.]]> 2017/8/30 17:15:12 LIANG Ge-zhi 281true ［Abstract］　Objective　To explore the clinical effect of a bionic air-bag midwifery skill by single expansion method in delivery.Methods　Eighty puerperae in accordance with the inclusion criteria were randomly divided into the observation group(n=40) and the control group(n=40). The bionic air-bag midwifery skill by single expansion method was used in the observation group when the cervix was dilated ≥5 cm. The duration of labor,delivery modes, perineum conditions, amount of postpartum hemorrhage and the rate of neonatal asphyxia were compared between the two groups.Results　The time of the first, second stage and the total labor duration in the observation group were significantly shorter than those in the control group(P<0.05). The amount of postpartum hemorrhage in the observation group within 2 h was significantly less than that in the control group(P<0.05). There were no significant differences in delivery modes, perineum conditions and the rate of neonatal asphyxia between the two groups(P>0.05).Conclusion　The bionic air-bag midwifery by single expansion method can shorten the laboring time and reduce the related complications during parturition.]]> 2017/9/1 11:34:47 YAO Juan-juan, DONG Lin-hong, DENG Yue-gui, et al. 280true ［Abstract］　Objective　To observe the effects of trimetazidine in the treatment of ischemic cardiomyopathy(ICM) patients with chronic heart failure(CHF) and diabetes mellitus.Methods　Sixty ICM patients（42 males and 18 females） were collected from the Central Hospital of Zhumadian City from January 2013 to June 2014, and were diagnosed as New York Heart Association(NYHA) Class Ⅲ～Ⅳ heart failure. All included patients were randomly divided into the control group and the treatment group. The treatment group was given the standard therapy including the angiotensin converting enzyme inhibitors(ACEI)/angiotensin receptor blockers(ARB), beta blockers, digitalis, diuretics and other medicines combined with trimetazidine 20 mg/TID(three times a day) to cure the heart failure for 6 months. The control group was given the same standard treatment combined with oryzanol for 6 months. Left ventricular end-diastolic diameter(LVEDD), left ventricular ejection fraction(LVEF), left ventricular end-systolic dimension(LVESD), and 6-minute walking test(6MWT) were measured and compared between the two groups 6 months after the treatment.Results　LVESD, LVEDD, LVEF and 6MWT in the treatment group improved better than those in the control group（P<0.05）. No adverse reactions were found in both of the two groups.Conclusion　Trimetazidine obviously improves the cardiac function of ICM patients with CHF and diabetes mellitus, and improves the quality of their lives.]]> 2017/9/1 11:34:47 GAO Yi-na, LIU Hao 279true ［Abstract］　Objective　To evaluate the efficacy and safety of intravitreal injection of ranibizumab for macular choroidal neovascularization(CNV).Methods　Twenty-six eyes of 26 patients diagnosed with macular choroidal neovascularization caused by age-related macular degeneration, high myopia macular degeneration and central exudative retinopathy were included in this study. Intravitreal injections of ranibizumab(0.5 mg/0.5 ml) were performed on all eyes. All patients were followed-up for 3 months, and the best-corrected visual acuity(BCVA), the central macular thickness(CMT) and complications were recorded.Results　During the follow-up period, the mean of BCVA improved from (17.65±13.96) letters to (34.23±16.36) letters after a follow-up of 3 months(P<0.05); the mean of CMT decreased from (310.84±113.13)μm to （198.76±46.90）μm after a follow-up of 3 months（P<0.05）. Retinal detachment, endophthalmitis, lens injury and systemic adverse reactions were not found.Conclusion　Intravitreal injection of ranibizumab is an effective and safe treatment for macular CNV.]]> 2017/9/1 11:34:47 CHEN Li-fei, LI Min, WU Xue-jin 278true ［Abstract］　Objective　To explore the clinical value of detecting serum PCT, hs-CRP and SAA in distinguishing local bacterial infection from systemic bacterial infection, and to provide the experimental basis for the diagnosis and treatment of infectious disease.Methods　The serum levels of PCT, hs-CRP and SAA were exmamined in the patients with local bacterial infection(n=92), systemic bacterial infection(n=120) and in the patients without infection(n=34). The relationships between the above indicators and bacterial infections were analyzed. ROC method and binary logistic regression were used to analyze the data.Results　There were significant differences in the serum levels of PCT, hs-CRP and SAA among the three groups(P<0.05). There were significant differences in the serum levels of PCT, hs-CRP and SAA beween the local bacterial infection group and the systemic bacterial infection group(P<0.05). The serum levels of PCT, hs-CRP and SAA in the patients with systemic bacterial infection was significantly higher than those in the patients with local bacterial infection and those without infection. The specificity, sensitivity and AUC of PCT were higher than those of hs-CRP and those of SAA for diagnosing systemic bacterial infection and for distinguishing local bacterial infection. The regression equation was log(p/1-p)=0.117+0.16×PCT+0.01×hs-CRP, which was obtained by the binary logistic regression analysis, in which the partial regression coefficient(B) of PCT was the biggest in the equation, indicating that PCT had higher efficiency for distinguishing local bacterial infection from systemic infection.Conclusion　The levels of serum hs-CRP, PCT and SAA can be used for the diagnosis of systemic bacterial infection. Compared with CRP, PCT is a good marker for the diagnosis of systemic bacterial infections, especially for the early diagnosis.]]> 2017/9/1 11:34:47 ZHU Xing-cheng, WANG Dong-ju 277true ［Abstract］　Objective　To observe the effects of Sanzizhike capsule and tiotropium in the treatment of chronic obstructive plumonary disease(COPD) in stable stage.Methods　Fifty-six patients with COPD in stable stage were randomly divided into two groups.The experimental group received Sanzizhike capsule with tiotropium while the control group was treated with tiotropium. Lung function, mMRC(modified medical research council) and the number of acute exacerbations were observed before and after the treatment in the two groups.Results　(1)There were no significant differences between the experimental group and the control group in gender, age, mMRC, lung function and the number of acute exacerbations. (2)One year after the treatment, mMRC, spirometry and the number of acute exacerbation in experimental group decreased significantly compared with those before the treatment, but these decreases were significantly slower than those in the control group(P<0.05).Conclusion　Sanzizhike capsule and tiotropium can reduce the rate of decline in lung function and the number of acute exacerbation, and also improve the mMRC.]]> 2017/9/6 16:16:49 ZHANG Zhi-yang, CAI Wei-ping, LIN Zhi-ping, et al. 276true ［Abstract］　Objective　To explore the method for the treatment of gynecological patients with abdominal poor wound healing.Methods　Seventeen cases of gynecological patients with abdominal poor wound healing were retrospectively analyzed in our hospital from January 2007 to December 2013. The debridement and modified suture were performed when wound infection or dehiscence occurred.Results　17 patients were discharged 7 to 9 days after the operation with good healing of incision.Conclusion　Modified suture is suitable for the postoperative Ⅱ suture.]]> 2017/9/6 16:16:49 LING Dan, ZHAO Ren-feng, HU Xiao-xia, et al. 275true ［Abstract］　Objective　To investigate the curative effect of resection of urethral polyp by high frequency argon knife in women.Methods　A retrospective study of 71 female patients with urethral polyps who were performed on removal of urethral polyps using high frequency argon knife were retrospectively analyzed.Results　71 patients were cured. A relapse of the disease occurred in one case in six month, and in two cases in 1 year. The recurrence rate was 4.2%; 1 case suffered from diabetes mellitus complicated with urinary tract infection. 1 case had mild stenosis of urethra.Conclusion　Using high frequency argon knife to remove urethral polyps is effective and worthy of clinical promotion.]]> 2017/9/6 16:16:49 FAN Song-qiang, WANG Guo-qiao 274true ［Abstract］　Objective　To investigate the key points in the early diagnosis and early treatment of acute superior mesenteric artery embolism(ASMAE), to avoid misdiagnosis, and to reduce disability and mortality rate.Methods　The clinical data from January 2004 to January 2011, of ASMAE in 46 cases were retrospectively analyzed.Results　The course of disease was within 1 hour to 10 days. 46 patients were treated with abdominal CT and abdominal computed tomography angiography(CTA) examination to confirm the diagnosis of ASMAE. The intestinal resection was performed on 28 cases and percutaneous superior mesenteric artery catheter thrombolysis was performed on 10 cases. The superior mesenteric artery thrombectomy vascular reforming was done in 8 cases. 5 patients died perioperatively. 8 patients had short bowel syndrome and all died within a follow-up of 3 years. The rest 33 cases were followed up for 3 years and all recovered well.Conclusion　At the early stage of ASMAE, if the sudden severe abdominal pain symptoms do not match with atypical signs, ASMAE should be done as early as possible. Abdominal CTA examination, early diagnosis and early treatment for the disease are the key points to reduce the disability and mortality rates.]]> 2017/9/6 16:16:49 TONG Lin-long, TONG Xian-zhou 273true ［Abstract］　Objective　To compare the predominant bacteriologic profiles among middle meatus of chronic rhinosinusitis (CRS) complicated with nasal polyps(CRSwNP) and without nasal polyps(CRSsNP), and the controls subjects.Methods　A total of 165 CRSwNP patients, 76 CRSsNP patients, 44 control subjects were recruited. Swab samples were obtained from the middle meatus during endoscopic sinus surgery and processed for the presence of aerobic and non-aerobic bacteria culture.Results　Mostly aerobic and facultative anaerobic bacteria were detected in the samples from the three groups, in which the most common aerobic bacteria were coagulase-negative Staphylococci, Corynebacterium species, Staphylococcus aureus and Haemophilus influenzae. In contrast, comparatively few anaerobic bacteria were isolated from the three groups. The isolation rates for aerobic and anaerobic bacteria were not significantly different among the three groups.Conclusion　The bacteriologic profiles in the nasal middle meatus are not significantly different in Chinese CRSwNP and CRSsNP patients or control subjects.]]> 2017/7/4 9:03:44 LIU Qing-hua, LI Rui-yu 272true ［Abstract］　Objective　To analyze the serological infection modules of hepatitis B virus in Dali, and to explain the results of HBV serological markers and to apply the markers correctly for clinicians to analyze HBV infection status.Methods　The serum HBV markers were quantitatively detected by chemiluminescence immunoassay in 8 303 patients, and 1, 2, 3, 4, and 5 represented the HBsAg, HBsAb, HBeAg, HBeAb and HBcAb respectively.Results　Fifteen serological infection modules of hepatitis B virus were found in which, “1, 2, 3, 4, 5” negative accounted for 47.3%, “2” positive accounted for 16.9% “2, 5” positive accounted for 12.5%, “2, 4, 5” positive accounted for 12.1%, “1, 4, 5” positive accounted for 4.62%, “5” positive accounted for 3.06%, “4, 5” positive accounted for 1.73% and “1, 3, 5” positive accounted for 0.97%.Conclusion　The average positive rate of HBV is lower in Dali population than in China population.]]> 2017/7/4 9:03:44 ZHU Xing-cheng, WANG Dong-ju 271true ［Abstract］　Objective　To investigate the short and long term effects and complications of intensive immunosuppressive therapy in combination with cord blood infusion treatment of severe aplastic anemia(SAA).Methods　Fifty-four patients with SAA in our hospital from June 1998 from September 2015 were divided into the treatment group and the control group, according to whether the use of CTX and the infusion of umbilical cord blood. Thirty cases of the treatment group were treated with ATG+CsA+CTX+cord blood infusion solutions: ATG 3.5 mg/（kg·d） D1～D5, CsA 3～5 mg/（kg·d）, CTX total 75 mg/kg, D2～D3, infusion of umbilical cord blood for one day 3～5 days after using ATG. 24 cases of the control group were treated with ATG+CsA: ATG 3.5 mg/（kg·d） D1～D5, CsA 3～5 mg/（kg·d）.Results　For the treatment group: the median time of neutrophil count>0.5×10⁹/L was 16(7～28)days, and the median time of platelet count>20×10⁹/L was 46(12～132)days; The infection rate was 60%, and the infection mortality rate was 13%. The overall survival rate was 77.0%, after a median follow-up of 28 months(1.2～176), and the disease-free survival rate was 66.7%. For the control group: the median time of neutrophil count>0.5×10⁹/L was 21(3～42)days, and the median time of platelet count>20×10⁹/L was 56(12～102)days, the infection rate was 67%, and infection mortality rate was 17%. After a median follow-up of 20(0.9～118)months, the overall survival rate was 70.8%, the disease-free survival rate was 62.5%. There was significantly different in neutrophil recovery time but not different in platelet recovery time between the two groups. There were no significant differences in the clinical effect, the incidences of infection, mortality, total efficiency and survival rates between the two groups.Conclusion　Compared with the standard ATG+CsA program, intensive immunosuppressive therapy combined with umbilical cord blood infusion has shorter bone marrow emptiness, and shorter neutrophil recovery time. It is clinically feasible, and dose not increase the treatment-related side effects and the incidence of infection and mortality.]]> 2017/7/4 9:03:44 LI Yu-miao, WANG Shun-qing, ZHANG Yu-ping, et al 270true ［Abstract］　Objective　To explore the behavior of children with attention deficit hyperactivity disorder(ADHD) in Guangxi and the relationship with their parental rearing patterns.Methods　The behaviors of children aged 7～9 years in our hospital were assessed by SNAP-Ⅳ and they are divided into ADHD group(n= 56) and the control group(n=74). Their parental rearing patterns were measured with Parent Symptom Questionnaire(PSQ) and Egna Minnen av Barndoms Uppfostran(EMBU) respectively.Results　(1)Compared with those in the control group the children in ADHD group had significant higher scores for the conduct problems, impulsivity-hyperactivity and hyperactivity index of the PSQ（P<0.05）.(2)There were no significant differences in the behaviors of children among different types of ADHD（P>0.05）.(3)More scores of spoiling children and authoritarian factor and less scores of democrafic factor that were gotten from parents′ education were found in the ADHD group than those in the control group（P<0.05）.(4)There were no significant differences in the scores of parents′ different modes of education among different types of ADHD（P>0.05）.(5)The behaviors of children in low grades of elementary school were significantly corrrelated with their family education types and family rearing patterns.Conclusion　The children with ADHD in Guangxi have abnormal behavioral characteristics and bad parental rearing patterns, suggesting that comprehensive intervention should be considered for ADHD children.]]> 2017/7/4 9:03:44 LEI Ling, ZHENG Bin 269true ［Abstract］　Objective　To summarize the experience of laparoscopic pancreatic exploration and drainage in late-term pregnancy complicated with acute pancreatitis after caesarean section.Methods　The clinical data of 17 cases with late-term pregnancy complicated with acute pancreatitis from March 2010 to March 2015 in our hospital were retrospectively analyzed.Results　Of 17 cases with acute pancreatitis, 5 cases had edema pancreatitis and recovered well; 12 cases had pancreatic necrosis in which 1 case died of multiple organ dysfunction, 2 cases had small abscess, 3 cases had pancreatic pseudo cyst.Conclusion　Laparoscopic pancreatic exploration and drainage is effective and suitable for the treatment of acute pancreatitis in late-term pregnancy after caesarean section.]]> 2017/7/10 17:13:59 ZHANG Chun-li, JIA Xiao-hui, SUN De-li 268true ［Abstract］　Objective　To study the vaue of P16 and P53 proteins in the differential diagnosis between endometrial serous carcinoma and endometrioid carcinoma.Methods　The expressions of P16 and P53 were evaluated by immunohistochemistry method in endometrial serous carcinoma and endometrioid carcinoma.Results　The expression of P16 in six cases with endometrial glandular cancer was focally or flakily positive in the cancer cells′ nucleus and cytoplasmes, and its positive rate was from weak to medium intensity. The expression of P16 in eighteen cases with uterine serous carcinoma was diffuse and strong, and it was moderately positive in two cases. There was significant difference in the expression of P16 between the two different cancers(χ²=26.61，P<0.01). The expression of P53 in seven cases with endometrial glandular cancer was focally and flakily positive(from weak to medium intensity) in the cancer cell nucleus, and the expression in eighteen cases with uterine serous carcinoma was diffuse and strong. There was significant difference in the expression of P16 between the two different cancers(χ²=21.94，P<0.01). The positive rates of P16 and P53 were strongly correlated(r_s=0.687, P=0.001).Conclusion　The expressions of P16 and P53 in uterine serous carcinoma are stronger than those in endometrial carcinoma, which plays an important role in the differential diagnosis between the two different cancers. The positive rate of P16 strongly correlated with P53 in uterine serous carcinoma, which plays an important role in its development.]]> 2017/7/10 17:13:59 WEI Li, LIU Peng, LIU Meng-meng, et al. 267true ［Abstract］　Objective　To investigate the correlation between intra-abdominal hypertension(IAH) and the severrity of acute pancreatitis(AP).Methods　Fifty-eight patients with acute pancreatitis were divided into the mild acute pancreatitis(MAP) group and the severe acute pancreatitis(SAP) group. The intra-abdominal pressure(IAP) were compared between the two groups and the correlation between APACHEⅡ scores and IAP was analyzed. The hospital stay, morbidity, and mortality incidence of complications were compared between the two groups. The patients of SAP group were divided into two subgroups: IAH subgroup and non-SAP IAH subgroup, and their clinical data were comparad.Results　The incidence of IAH was 0.00% in MAP group, and 65.22% in SAP group,with a significant difference(P<0.01). There were significant differences in the hospital stay, incidence of complications and mortality between MAP group and SAP group(P<0.01). In SAP patients, there was a correlation between IAP and APACHEⅡscores.Conclusion　IAH significantly affects the severity of AP, and SAP patients should be monitored by IAP, for early diagnosis and treatment.]]> 2017/7/10 17:13:59 LI Tian-man, ZHOU Ren, PANG Zhi-dong 266true ［Abstract］　Objective　To assess the methodological and reporting qualities of Meta-analyses published in Chinese Journal of Preventive Medicine.Methods　The Meta-analyses published in Chinese Journal of Preventive Medicine from January 1998 to December 2014 were retrieved by computer or manual retrieval systems. The methodological and reporting qualities of Meta-analysis were evaluated by using both Assessment of Multiple Systematic Reviews (AMSTAR) and Preferred Reporting Items for Systematic Reviews and Meta-Analysis(PRISMA) scales.Results　A total of 31 papers were included. The scores of the evaluation of the methodological quality were 3 to 8(median 7) points in the included papers, of which 0 articles(0.0%) scored 9～11 points, 28 articles(90.3%) scored 5～8 points and 3 articles(9.7%) scored 0～4 points. The rate of matched items was low including those that were in accordance with the included and excluded criteria, those that needed to be verified the scientificity of the inclusive criteria and those that needed to be disclosed the conflict of interest. The scores of the reporting quality were 10.5 to 23.5(17.32±3.71) points in the included papers, of which 9 papers(29.0%) scored less than 15 points, 17 papers(54.8%) scored 15.5～21 points and 5 papers(16.2%) scored 21.5～27 points. The titles of PRISMA scales with a lack of comprehensive reports were the “Objective of introduction” in the introductions, the “Protocol and registration”, “Study selection”, “Data collection process”, “Data items” and “Risk of bias in individual studies” in the methods, the “Study selection” and “Risk of bias across studies” in the results, the “Conclusion limitations” in the conclusions and the “Funding support” in the acknowledgements.Conclusion　The methodological and reporting qualities of Meta-analysis published in the Chinese Journal of Preventive Medicine are moderate, both of which still require further improvement.]]> 2017/7/10 17:13:59 WEI Suo-su, WEI Hui-de, HUANG Xiao-hong, et al. 265true ［Abstract］　Objective　To summarize the clinical, immunological and pathological features of primary biliary cirrhosis(PBC).Methods　The data of 44 PBC patients were retrospectively analyzed, including the general information, clinical characteristics, and results of the biochemical, immunological and pathological examinations.Results　Most of the PBC patients were women,with a mean age of (57.68±10.71)years, and the ratio of male to female was 1∶7.8. Of all the patients, 52.27% were presented with abnormal liver function hepatitis, 25.00% with cirrhosis and 11.36% with autoimmune liver diseases. The main clinical manifestations included fatigue(56.82%), pruritus(38.64%), jaundice(84.5%), xerostomia and keratoconjunctivitis sicca(34.09%). PBC complicated with autoimmune hepatitis(AIH) covered in 15.91% patients, and those complicated with other autoimmune diseases accounted for 56.82%. Biochemical examination showed the elevated levels of serum alkaline phosphatase(ALP) and serum gamma glutamyl transpeptidase(GGT) in PBC patients. High levels of immunoglobulin M(IgM) were tested in most PBC patients. The positive percentage of antinuclear antibody(ANA) was 95.45%, and antimitochondrial antibody(AMA) and antibody of anti-mitochondrial M2 subtype(AMA-M2) were 90. 91%. In 25 patients who received liver biopsy, the main histopathological changes were: punctiform and focus-form necrosis, piecemeal necrosis, necroinflammation of interbobular bile ducts, smaller bile duct proliferation, fibrosis, pseudolobular formation inflammation aggregation around small bile duct, anuloma formation, small bile duct vanish, feathery degeneration of hepatocytes, bilirubi-nostasis in canaliculi and cholangitis of interlobular bile ducts.Conclusion　PBC occurs more frequently in females than in males, and the onset and clinical features are not typical. The liver function test reveals acholestatic pattern. Positive AMA/ AMA-M2 may be crucial to the diagnosis of PBC.The histopathologial hallmorks of PBC are mecroinflammation and ductopenia involved mainly in the interlobular bile ducts, lymphocyte aggregation,granuloma formation and bile ductular proliferation in the portal area; and feathery degeneration of the hepatocytes.]]> 2017/7/10 17:15:23 WANG Hai-xia, ZHANG Cai-cai, SONG Qi-shuang 264true ［Abstract］　Objective　To analyze the clinical manifestations and pathological characters of kidney diseases in elderly patients.Methods　We collected 51 kidney disease patients more than 60 years old in our hospital from January 2011 to December 2014 and analyzed their clinical manifestations and pathological characters.Results　All of the 51 cases with kidney diseases were diagnosed by renal biopsy, of whom 33 cases suffered from primary glomerular disease. The most common indication for renal biopsy was nephrotic syndrome(54.90%), followed by nephritic syndrome(19.61%) and chronic kidney injury(9.80%). The most common renal histopathology in primary glomerular disease was idiopathic membranous nephropathy(51.52%), followed by IgA nephropathy(15.15%) and mesangioproliferative glomerulonephritis(12.12%). HBV-related glomerulonephritis(HBV-GN 22.22%) was the most common secondary kidney disease, followed by ANCA-associated vasculitis(16.67%), and amyloidosis(16.67%).Conclusion　Primary glomerular disease is the most common renal disease in elderly patients. Membranous nephropathy and HBV-related glomerulonephritis are the most common primary renal disease and the secondary renal disease, respectively. Nephrotic syndrome is the major clinical indication of renal biopsy in the elderly.]]> 2017/7/10 17:15:23 LIU Xiao-cong, SHAO Si-nan, ZHANG Yan-lin 263true ［Abstract］　Objective　To evaluate the clinical effect and safety of tenofovir(TDF) and entecavir(ETV) on the treatment of hepatitis B E antigen-positive chronic hepatitis B(CHB) with high viral load.Methods　Eighty patients with hepatitis B E antigen-positive CHB and high viral load were collected in our hospital and were randomly divided into two groups. TDF group was treated with tenofovir, 300 mg po qd; the ETV group was treated with entecavir, 0.5 mg po qd. HBV-DNA negative conversion rate, HBeAg negative conversion rate and ALT levels were observed 4,12, 24 and 48 weeks after the treatment.Results　The HBV-DNA negative conversion rates in the TDF group（62.5%, 77.5%, 95.0%, 100%） were significantly higher than those in the ETV group（25.0%, 55.0%, 72.5%, 95.0%） 4 , 12, 24 and 48 weeks after the treatment(P<0.05). There were no significant differences in HBeAg negative conversion rates between the two groups 4 and 12 weeks after the treatment(P>0.05), however, HBeAg negative conversion rates of the TDF group were significantly higher than those of the ETV group 24 and 48 weeks after the treatment(P<0.05). There was no significant difference in the ALT normalization rate between the two groups(P>0.05).Conclusion　TDF is more effective than ETV in the treatment of high viral load HBeAg positive CHB]]> 2017/7/10 17:15:23 WANG He, XING Zhi-yuan, SUN Feng-bo, et al. 262true ［Abstract］　Objective　To analyze the impact factors of acute kidney injury(AKI) in critical patients by a classification tree model.Methods　A total of 314 patients admitted to our ICU from March 2012 to January 2014 were included. The clinical data of the patients were recorded to analyze the impact factors of AKI using the Exhaustive CHAID classification tree model.Results　Four important explanatory variables were screened out by the classification tree model from the 34 candidate variables related to AKI, including Glasgow coma scale, shock, administration of HES and blood glucose.Conclusion　The classification tree model can effectively analyze the major impact factors of AKI in critical patients. Glasgow coma scale, shock and blood glucose are the risk factors of AKI.]]> 2017/7/10 17:15:23 WANG Zheng-guang, ZHANG Mu-cheng, HUANG Rong, et al. 261true ［Abstract］　Objective　To investigate the effectiveness and safety of radiofrequency catheter ablation under the guidance of Ensite3000 system for atrial fibrillation(AF) without organic heart lesion.Methods　Thirty-six inpatients, including 30 cases with paroxysmal atrial fibrillation and 6 cases with persistent AF were collected from July 2013 to May 2015 and radiofrequency ablation was performed on them under the guidance of the Ensite3000 system. The success rate, the recurrence rate and the complications were respectively analyzed.Results　All of the cases were performed the radiofrequency ablation successfully, with recurrent AF in 3 cases, recurrent with atrial tachycardia in 3 cases postoperative complications in 3 cases and a success rate of 83.3% during the follow-up period of 3 to 12 months.Conclusion　Circumferential pulmonary vein ablation under the guidance of Ensite3000 system is safe and effective for AF.]]> 2017/7/10 17:15:23 LI Qing-kuan, QIN Shao-ming, LU Zhi-hong, et al. 260true ［Abstract］　Objective　To study the clinical effect of laparoscopic hepatectomy on recurrent hepatocellular carcinoma.Methods　From April 2012 to October 2015, a total of 34 patients with recurrent hepatocellular carcinoma in our hospital were taken as the clinical research subjects, and they were randomly divided into the laparoscopic group(n=17) and the laparotomy group(n=17). The laparoscopic group was given laparoscopic hepatectomy, and the laparotomy group was given open hepatectomy. The intraoperative and postoperative conditions, and 1-year postoperative recurrent rate were compared between the two groups.Results　The operative time, intraoperative blood loss and postoperative pain index in the laparoscopic group were significantly lower than those in the laparotomy group［（93.28±46.45）min vs（126.43±39.13）min, （122.68±52.74）ml vs（237.81±76.39）ml,（4.52±2.39）vs（6.71±1.85）］（P<0.05）.Conclusion　Laparoscopic hepatectomy can be used as the first choice for recurrent hepatocellular carcinoma because of the advantages of smaller wound and less blood loss and faster recovery.]]> 2017/9/26 8:05:56 XIE Yong, MA Xiao-fei, LIU Xiao-ping, et al. 259true ［Abstract］　Objective　To investigate the clinical efficacy and safety of uterine artery chemoembolization for the treatment of placenta implantation.Methods　From January 1, 2007 to September 31, 2013,17 patients with placenta implantation were treated with uterine artery chemoembolization at the First Affiliated Hospital of Guangxi Medical University. The patients in group B were treated simultaneously with Rivanol intra-amniotic membrane injection for artificial laboring. The postpartum hemorrhage, placental tissue residue discharge time, β-HCG clearance time, recovery time of menstruation and puerperal infection were observed in all the patients.Results　Two cases needed hysterectomy because of severe hemorrhage. 15 cases were successfully treated with chemoembolization(88.24%). The placentas of 10 cases were self-absorbed or discharged, with an average of （70.50±25.82 ）days. The serum β-HCG dropped from 80.0% to 97.5% during one week, and decreased to the normal range of （32.5±15.83 ）days. The average time of getting normal menses was （52.27±20.25 ）days. The average amount of blood loss of group A(830±141.81)ml was significantly less than that of group B(316.67±116.91)ml(P<0.01). There were no significant differences in the serum β-HCG decreasing to normal, getting normal menses and puerperal infection between them. The time of the serum β-HCG decreasing to normal and getting normal menses when using curettage was shorter than that when not using curettage(P<0.01), but hysterectomy, puerperal infection and postpartum hemorrhage were not different.Conclusion　The treatment of placental implantation using uterine artery chemoembolization can reduce postpartum hemorrhage, reserve uterus, and combining with chemoembolization curettage can reduce the time of the serum β-HCG decreasing to normal and getting normal menses.]]> 2017/9/26 8:05:56 WANG Juan, WANG Su-mei 258true ［Abstract］　Objective　To explore the value of combining detection of sputum mycoplasma pneumonia DNA(MP-DNA) with serum MP antibody in the early diagnosis of mycoplasma pneumoniae(MP) in children.Methods　213 children with suspected mycoplasma pneumoniae infection were detected using sputum MP-DNA method and serum MP-IgM antibody respectively. The diagnostic values of the two methods and their combing method were compared.Results　In the 213 children with suspected MP infection, 100 cases(46.95%) were diagnosed with MP infection. The detection specificity, sensitivity, negative predictive values and positive predictive value of the combining method were all superior to those of the sputum MP-DNA method or the serum MP-IgM method, P<0.05. There was no significant difference in the detection rate between the sputum MP-DNA method and the serum MP-IgM method, P>0.05.Conclusion　Using sputum MP-DNA method combined with serum MP-IgM antibody assay can significantly improve the accuracy of the early diagnosis of mycoplasma pneumonia in children.]]> 2017/9/26 8:05:56 ZHANG Zhi-ying, HAN Shu-juan, ZHANG Xiao-ning, et al. 257true ［Abstract］　Objective　To observe the effects of dexmedetomidine on the combined spinal and epidural anesthesia in the parturients undergoing cesarean section.Methods　A total of 100 parturient women with ASA Ⅰ or Ⅱ were randomly divided into the dexmedetomidine group and the control group, 50 cases in each group. Dexmedetomidine was rapidly infused intravenously within 2 to 3 minutes at the loading dose of 0.5 μg/kg after umbilical cord was cut, and was maintained at the rate of 1 μg/（kg·h） until the end of surgery. The paramenter women including systolic blood pressure（P₁） and heart rate(HR₁) at preanesthesia, the systolic blood pressure after childbirth（P₂）, the lowest systolic blood pressure(P₃) and the fastest heart rate(HR₂) during operation, the total amount of ephedrine, the complications of dragging pain, nausea and vomiting, shiver, anesthesia satisfactions from anesthesiologists and parturient women, and the incidences of adverse reactions of intraoperative respiratory depression and excessive postoperative sedation were compared between the two groups.Results　There were no significant differences in P₁ and HR₁（P>0.05） and there were significant differences in P₂, P₃, HR₂ and the total amount of ephedrine between the two groups（P<0.01）; There were significant differences in the dragging pain, nausea and vomiting, shiver; anesthesia satisfactions from the anesthesiologists and parturient women（P<0.01）, and there were no significant differences in the incidences of adverse reactions of intraoperative respiratory depression and excessive postoperative sedation between the two groups（P>0.05）.Conclusion　Dexmedetomidine is a safe, effective and comfortable auxiliary anesthetic agent for the the combined spinal and epidural anesthesia in the parturient women undergoing cesarean section.]]> 2017/9/26 8:05:56 DENG Zhe 256true ［Abstract］　Objective　To investigate the significance of transcutaneous oxygen pressure(TcPO₂) in the diagnosis of lower extremity atherosclerotic disease in diabetic foot by comparison with ankle brachial index(ABI).Methods　496 inpatients with type 2 diabetes were collected in our department during January 2015 and June 2016, including 295 males and 201 females, with an average age of (59.84±11.66)years, and a duration of diabetes being 0.1 to 35 years. According to the different diagnoses, the patients were divided into CO group(with no diabetic peripheral neuropathy and no lower extremity atherosclerotic disease, n=95), DPN group(with diabetic peripheral neuropathy but no lower extremity atherosclerotic disease, n=139), LEAD group(with lower extremity atherosclerotic disease but no diabetic peripheral neuropathy, n=83) and N+A group(with diabetic peripheral neuropathy and lower extremity atherosclerotic disease, n=179). The levels of ABI and TcPO₂ were compared among the groups.Results　There were no significant differences in age, blood pressure and body mass index(BMI) among the groups(P>0.05). There was no significant difference in the duration of diabetes between DPN group and LEAD group(P>0.05), but there was a significant difference between the other two groups(P<0.01). There was no significant difference in the level of HbA1c(P>0.05) between CO group and DPN group, or between LEAD group and N+A group, but there was significantly different between the other two groups(P<0.01). There were significant differences in the levels of TcPO₂ and ABI between the two groups(P<0.05), except for the comparison between CO group and DPN group(P>0.05). ROC curve analysis showed that TcPO₂ was better than ABI to diagnose the diabetic lower extremity atherosclerotic disease.Conclusion　TcPO₂ can truly reflect the microcirculation of lower limbs of the patients with diabetes, and therefore is better than ABI to diagnose lower extremity atherosclerotic disease.]]> 2017/8/29 17:08:47 XU Guo-ling, YAN Xiao-dong, YU Yan-qing 255true ［Abstract］　Objective　To study the characteristics of 24-hour ambulatory blood pressure, changes of abnormal electrocardiogram(ECG) and the relationship between them in preeclampsia pregnant women.Methods　95 preeclampsia pregnant women were collected, and were divided into group A(with severe preeclampsian, n=46) and group B(with mild preeclampsia, n=49) according to the severity of the disease. Other matched 45 normal pregnant women were enrolled as the control group(group C) during the same period. The three groups were similar in age, pregnant times and body weight. 24-hour ambulatory blood pressure monitoring(ABPM) and ECG examination were performed in all the patients. The characters of 24-hour blood pressure and changes of abnormal ECG were analyzed.Results　(1)The ABPM indexes of preeclampsia women were significantly higher than those of the pregnant women in the control group. The levels of 24hSBP, 24hDBP, dSBP, nSBP, nDBP, dMAP, nMAP, SL, dHR, nHR and 24hHR in group A were significantly higher than those in group B（P<0.05）. The nighttime blood pressure decrease rate(MBP) of group A or group B was less than <10%. Circadian blood pressure of “non dipper” change was 89% in group A, and 68% in group B.(2)The rate of abnormal ECG in group A was significantly higher than that in group B or group C（P<0.05）.Conclusion　The blood pressure circadian rhythm is “non dipper type” in most preeclampsia pregnant women. The higher level of blood pressure, the more rate of abnormal ECG occurs in preeclampsia pregnant women.]]> 2017/8/29 17:08:47 GUAN Jian, CHEN Xiao-yan 254true ［Abstract］　Objective　To compare the clinical effect of proximal femoral nail anti rotation intramedullary nail(PFNA) and minimally invasive internal fixation system distal femur(LISS-DF) internal fixation on the treatment of intertrochanteric fracture in the elderly.Methods　64 elderly patients with intertrochanteric fractures in our hospital were selected and divided into two groups by a draft lottery, with 32 cases in each group. The control group was treated with LISS-DF internal fixation treatment, and the observation group was treated with PFNA. The surgical results and the postoperative complications were compared between the two groups.Results　The operation time and loading time in the observation group were significantly shorter than those in the control group(P<0.01); The incision length, intraoperative bleeding volume and postoperative drainage volume in the observation group were significantly reduced compared with those in the control group(P<0.01). There were no significant differences in the fracture healing time, hospitalization time and complications between the two groups(P>0.05).Conclusion　PFNA is effective in the treatment of elderly femoral intertrochanteric fracture. It can effectively shorten the operation time, loading time, and incision length, and reduce the amount of bleeding and postoperative wound drainage.]]> 2017/8/29 17:08:47 ZHOU Jie, ZHANG Peng-yuan, WU Jun-tao, et al. 253true ［Abstract］　Objective　To investigate the distribution characteristics and clinical significances of irregular antibodies.Methods　111 patients with positive irregular antibodies in screening from January 2014 to July 2016 were tested for antibody specificity by the saline method and the antiglobulin method.Results　Among the 111 cases tested for positive irregular antibodies, autoantibodies can be detected in 15 cases, and autoantibodies and isotype antibodies in 3 cases. Antibody specificity was not detected out in 24 cases of 76 cases, alloantibodies were detected in 69 cases, including 7 cases of combined antibodies. The positive rate was high in Rh system, MNS system and Lewis system, which accounted for 52.63%, 28.95% and 10.53% respectively. The top four antibodies were anti-E(34.21%), anti-Mur(17.11%), Anti-M(10.53%) and anti-Le^a(10.53%). The positive rate was high in the patients who had hematologic disease and pregnancy, which accounted for 27.03% and 20.72% respectively.Conclusion　It is necessary to detect irregular antibodies before blood transfusion, especially for the patients who have a history of blood transfusion or pregnancy.]]> 2017/8/29 17:08:47 MENG Xia, LI Hai-lan 252true ［Abstract］　Objective　To study the correlation among the three appraisal tools(AGREE Ⅱ, Shaneyfelt and Grilli) and to provide a better way for clinicians to appraise and choose clinical guidelines.Methods　The three tools were used to appraise the guidelines for chronic heart failure published in Journals in English or Chinese from 2000 to 2014, and the scores of each guideline were recorded by each tool and their correlation was analyzed. The recommendation of the guideline was assessed by AGREE Ⅱ and the appraisal criterions of Shaneyfelt and Grilli were established.Results　r₁(AGREE Ⅱ and Shaneyfelt)=0.908, r₂(AGREE Ⅱ and Grilli)=0.812, r₃(Shaneyfelt and Grilli)=0.784, and all the r values were significant at 0.01 level. The mean scores of guidelines assessed by AGREE Ⅱ as “recommend”, “recommend（after revised）” and “would not recommend” in Shaneyfelt were（18.90±2.30）, （14.20±1.20） and （10.67±2.11） respectively, while those in Grilli were （2.50±0.50）, （1.70±0.60） and （0.65±0.45） respectively.Conclusion　（1）There is significant correlation among the three tools.（2）From the appraisal criterions of Shaneyfelt, it was considered as “recommend” if score≥16, as “recommend（after revised）” if 13～15, and as “would not recommend” if ≤12; From the appraisal criterions of Griili, it was considered as “recommend” if score≥2, while as “would not recommend” if ≤1.]]> 2017/8/29 17:08:47 HE Wei-min, HUANG Jing-wen, LUO Shao-jin, et al. 251true ［Abstract］　Objective　To investigate the clinical effect of the combination of three dimensional conformal radiotherapy and rituximab on the treatment of advanced non-small-cell lung cancer.Methods　82 patients with advanced non-small-cell lung cancer were divided into two groups according to the order of lot, with 41 cases in each group. Three dimensional conformal radiation therapy was implemented in the control group, and the observation group was treated with intravenous injection of 100 mg for 8 times on the basis of the treatment that was given to the control group. The levels of vascular endothelial growth factor(VEGF), matrix metalloproteinases-9(MMP-9), cancer embryo antigen(CEA), cell keratin 19 fragment(CYFR21-1) and the clinical efficacy were compared between the two groups.Results　After the treatment, the levels of VEGF, MMP-9, CEA and CYFR21-1 in the observation group were significantly lower than those in the control group(P<0.01). In the observation group, the treatment outcome was markedly effective in 24 cases, effective in 13 cases and invalid in 4 cases. In the control group, the treatment outcome was markedly effective in 14 cases, effective in 13 cases and invalid in 14 cases. The curative effect of the observation group was better than that of the control group(P<0.01).Conclusion　Three dimensional conformal radiotherapy in combination of rituximab is effective for the patients with advanced non-small-cell lung cancer.]]> 2017/8/29 17:08:47 WANG Fen 250true ［Abstract］　Objective　To investigate the relationship between interaction of cyclooxygenase(COX) gene polymorphism and aspirin resistance in patients with ischemic stroke.Methods　719 patients with the first onset of ischemic stroke were treated in our hospital from June 2015 to May 2016, and they were treated with aspirin. The platelet aggregation rate was determinated by optical turbidimetry. The clinical data were collected, and the COX-1, COX-2 gene polymorphisms were determinated. The clinical data of the patients with aspirin resistance or aspirin sensitive were studied by means of single factor analysis, and the relationship between COX-1, COX-2 gene polymorphisms, their interaction and aspirin resistance was analyzed.Results　176 cases were included in the aspirin resistance group and 543 cases in the aspirin sensitive group. The proportion of women, diabetes, the levels of low density lipoprotein and fasting blood glucose in the aspirin resistance group were significantly higher than those in the aspirin sensitive group(P<0.05). There were no significant differences in the genotype distributions of COX-1 and COX-2 between the two groups(P>0.05). Diabetes, interactions between rs3842787 and rs20417 were the risk factors of aspirin resistance(P<0.05).Conclusion　The interactions of COX between two or among three multi-locus genotypes or more may increase the risk of aspirin resistance.]]> 2017/7/28 17:24:59 GUAN Rui-lei, SUN Jun-mei, HE Cai-hong, et al. 249true ［Abstract］　Objective　To explore the effect of modified Seldinger technique on the success rate of the radial artery puncture and postoperative complications in the patients with coronary heart disease.Methods　300 patients with coronary heart disease were collected and their radial arteries were punctured by modified Seldinger technique. The success rate, the puncture time and the postoperative complications were recorded.Results　The success rate of modified Seldinger technique for radial artery puncture was 100.0%. The mean time for radial artery puncture in all cases was(233±78) seconds. It took(203±53) seconds in the male and (280±88) seconds in the female patients. Artery spasm was present in 28 cases（9.3%）. Local hematoma was present in 15 cases（5.0%）. Obliteration of the radial artery was present in 17 cases（5.7%）.Conclusion　Modified Seldinger technique is safe and has a high success rate of radial artery puncture in the patients with coronary heart disease.]]> 2017/7/28 17:24:59 WANG Jun-xian 248true ［Abstract］　Objective　To evalute the effects of Acanthopanax senticosus injection on the levels of endothelin（ET-1） and nitric oxide（NO） and lung function in the patients with chronic obstructive pulmonary disease(COPD).Methods　107 patients with stable COPD were divided into the treatment group and the control group. The treatment group(n=54) received the conventional treatment of western medicine plus acupuncture treatment combined with Acanthopanax senticosus. The control group(n=53) received the same treatment of western medicine as the treatment group. The levels of plasma NO and ET-1 and lung function were compared between the two groups.Results　The levels of plasma NO and ET-1 and lung function in the treatment group were significantly improved, and better than those in the control group(P<0.05).Conclusion　Acanthopanax senticosus may effectively improve the clinical efficacy of COPD patients with stable stage of lung function and delay the progression of the disease through changing the levels of plasma NO and ET-1.]]> 2017/7/28 17:24:59 SONG Ben-yan, HU Qiang 247true ［Abstract］　Objective　To discuss the mechanism, treatment and prognosis of mirror syndrome associated with acute kidney injury.Methods　4 patients with mirror syndrome associated with acute kidney injury were collected from the People′s Hospital of Qingyuan City during January 2008 and June 2016 and their clinical data were retrospectively analyzed.Results　All of the 4 cases had oliguria［<0.5 ml/(kg·h)］, among whom 2 had high blood pressure. Three patients terminated through vagina, and the rest was terminated by cesarean. All of the 4 patients were treated with furosemide, and the total dose was up to 60～80 mg. All of the four patients recovered immediately after the termination, and the recovery time was between 14 and 16 days.Conclusion　（1）The key points to improve the prognosis of mirror syndrome with acute kidney injury are early diagnosis and timely termination of pregnancy.（2）The timing and dose of loop diuretics need further study.]]> 2017/7/28 17:24:59 SHE Qin, PENG Cui, TAN Wei-he, et al. 246true ［Abstract］　Objective　To establish a conformity test model for inspecting tenofovir disoproxil fumarate tablets by near-infrared reflectance spectroscopy(NIRS).Methods　The method of first derivative（FD） and vector normalization(SNV) was employed to pretreat the corresponding near spectroscopy spectral of tenofovir disoproxil fumarate tablets with the spectral ranges of 12 000～4 000 cm^-1, the optimum modeling band of 9 000～7 500 cm^-1, 6 900～5 600 cm^-1 and 5 000～4 250 cm^-1, the smoothing point of 17 and CI being 7. The conformity test model was constructed on the basis of the above parameters and was validated.Results　Using the conformity test model can distinguish the authentic from the inauthentic tenofovir disoproxil fumarate tablets by different inspectors and near-infrared instruments.Conclusion　The conformity test model is simple, accurate, feasible and suitable for the drug examination of tenofovir disoproxil fumarate tablets.]]> 2017/7/28 17:24:59 LI Yong, TAO Ming, ZHOU Yan-mei 245true ［Abstract］　Objective　To compare the clinical effect of percutaneous lumbar disc surgery on the treatment of recurrent lumbar disc herniation.Methods　82 patients with recurrent lumbar disc herniation who were treated in our hospital were divided into two groups according to the different operation methods, with 41 cases in each group. The control group was treated with lumbar disc nucleus pulposus, and the observation group was treated with percutaneous lumbar intervertebral foramen. The clinical effect was compared between the two groups.Results　The operation time, postoperative bed time and hospitalization time in the observation group were significantly shorter than those in the control group. The intraoperative bleeding volume of the observation group was significantly less than that of the control group(P<0.01). There were no significant differences in the visual analogue scale(VAS) and Oswestry disability index(ODI) between the two groups before and after the treatment(P>0.05).Conclusion　Percutaneous transforaminal endoscopic fenestration and surgical treatment of recurrent lumbar disc herniation have a similar clinical effect on the treatment of recurrent lumbal disc herniation, however percutaneous transforaminal endoscopic treatment can shorten the operation time, bed time and hospitalization time and reduce the amount of bleeding.]]> 2017/7/28 17:24:59 ZHANG Tian-ji, ZHOU Jie, WU Jun-tao, et al. 244true ［Abstract］　Objective　To investigate the correlation between the expressions of neuropilin-1(NRP) and vascular endothelial growth factor(VEGF), and microvessel density(MVD) in rectal cancer.Methods　64 specimens from the patients with rectal cancer in our hospital from June 2013 to June 2015 and their matched adjacent tissues were collected.These specimens were stained by immunohistochemistry and the MVD of rectal cancer was detected. The expression levels of NRP-1 and VEGF mRNA were detected by real-time reverse transcription(RT-PCR) method. The correlation between the expressions of NRP and VEGF and MVD was analyzed.Results　Compared with that of the adjacent normal tissues, the staining degree of the rectal carcinoma tissues was significantly increased and the range was significantly enlarged. The expression levels of NRP-1 and VEGF mRNA and their positive expression rate, and MVD in the rectal cancer tissues were significantly higher than those in the adjacent normal tissues(P<0.01). In the rectal cancer tissues,the expression level of NRP-1 mRNA in the tumors≥5 cm was significantly lower than that in the tumors <5 cm; the expression of NRP-1 mRNA in the rectal cancer that infiltrated deeply in the serous membrane with lymph node metastasis and C Dukes periodization was significantly higher than that in the rectal cancer that infiltrated out of the serous membrane without lymph node metastasis and A, B Dukes periodization(P<0.05); the expression of VEGF mRNA in the rectal cancer with low differentiation, infiltration deeply in the serous membrane and lymph node metastasis, C Dukes periodization was significantly higher than that in the rectal cancer with high differentiation, infiltration out of the serous membrane and lymph node metastasis, A, B Dukes periodization(P<0.05).The expression levels of NRP-1 and VEGF mRNA were positively correlated(P<0.05); NRP-1, VEGF and mRNA were correlated positively with MVD(P<0.05).Conclusion　The occurrence and progress of rectal cancer is closely related to high expression of NRP-1 which can improve VEGF activity and promote the formation of new blood vessels in the tumor, and enhance the ability of invasion and metastasis of rectal cancer, and may become a biological index to evaluate progression of rectal cancer.]]> 2017/6/28 15:27:54 ZHAO Peng-yue, ZHOU Hui-xing, LI Jun-hong 243true ［Abstract］　Objective　To investigate the clinical effects of intravascular ultrasound(IVUS) and fractional flow reserve(FFR) on coronary artery intervention in patients with coronary heart disease complicated with diabetes mellitus.Methods　136 patients with coronary heart disease and a diabetic history were enrolled and were divided into the control group(under CAG guidance, n=57), CAG+IVUS group(under CAG puls IVUS guidance, n=34) and FFR group(under CAG plus FFR guidance, n=45). The amount of implanted coronary stents and contrast agent, the total cost of hospitalization, the operative time, and the reoccurrence of angina and the incidence of major adverse cardiac events were compared among the three groups one year after discharge from the hospital.Results　The diameters of implanted stents in the IVUS group were significantly larger than those in the FFR group and the control group(P<0.05), but there was no significant difference between the control group and the FFR group(P>0.05). The number of stents in the control group was significantly larger than that in the FFR group or the IVUS group(P<0.05), but there was no significant difference between the FFR group and the IVUS group(P>0.05). The dosage of contrast medium in the control group was significantly higher than that in the IVUS group or the FFR group, and the dosage of contrast medium in the IVUS group was significantly higher than that in the FFR group(P<0.05). The hospitalization costs of the control group were significantly higher than those in the FFR group or the IVUS group（P<0.05）.Conclusion　The auxiliary measurement of FFR and IVUS interventional treatment can reduce the number of implanted stents and the dosage of contrast agent, and the costs of the hospitalization and reduce the incidence of angina after PCI in the patients with coronary heart disease.]]> 2017/6/28 15:27:54 HE Hao, QU Yi-xuan 242true ［Abstract］　Objective　To study the value of bipolar coagulation scissors on the laparoscopic surgery of gastrointestinal cancer.Methods　Two hundred and sixty-four gastrointestinal cancer patients who received laparoscopic surgery by the same surgeons from October 2011 to October 2014 in the department of general surgery of the People′s Hospital of Guangxi Zhuang Autonomous Region were included in this study. We divided the patients into the bipolar coagulation scissors surgery group(n=148) and the ultrasonic harmonic scalpel surgery group(n=116). The average operation time, blood loss, number of lymph node cleaning, average drainage 3 days after the surgery and the postoperative hospital stay were compared between the two groups.Results　The average operation time of the bipolar coagulation scissors surgery group was significantly shorter than that of the ultrasonic harmonic scalpel surgery group(P<0.01). There were no significant differences in the blood loss, number of lymph node cleaning and the average drainage 3 days after the surgery between the two groups(P>0.05).Conclusion　It is economic and feasible to perform laparoscopic surgery on the patients with gastrointestinal cancer using bipolar coagulation scissors.]]> 2017/6/28 15:27:54 LIU Chao, FENG Ze-rong 241true ［Abstract］　Objective　To study the protective effect and mechanism of Astragali Radix injection on acute gastric mucosa injury in mouse models.Methods　50 mice were randomly divided into the normal control group, the model group(treated with 0.9% NaCl injection), the cimetidine group(treated with cimetidine 25 mg/kg), the low Astragali Radix group(injected with Astragali Radix injection 300 mg/ml) and the high Astragali Radix group(treated with Astragali Radix injection 600 mg/ml). Then, the drugs were infused into the stomach of mice once a day for 2 weeks. 30 minutes after the last medication, the normal control group was injected with 0.9% NaCl while the model group, the low and high Astragali Radix groups were injected by gavage with 0.2% indomethacin solution. 4 hours later, the gastric mucosa injury was observed and the serum superoxide dismutase(SOD) and methane dicarboxylic aldehyde(MDA) were tested for each group.Results　Compared with that in the normal control group, the gastric mucosa injury in the drug intervention groups(treated with Astragali Radix injection and cimetidine) was more severe(P<0.01), however, the gastric mucosa injury in the drug intervention groups(treated with Astragali Radix injection and cimetidine) was milder than that in the model group(P<0.01). The gastric mucosa injury in high or low Astragali Radix injection group was milder than that in the cimetidine group(P<0.01). On the contrary, the levels of SOD and MDA in the model group were higher than those in the normal control group(P<0.01). Compared with those in the model group, the levels of SOD and MDA in the drug intervention groups(treated with Astragali Radix injection and cimetidine) were lower(P<0.01). The level of SOD in the high Astragali Radix injection group was significantly lower than that in the cimetidine group.Conclusion　Astragali Radix injection has a protective effect on acute gastric mucosa injury of mice, whose mechanism may be related to reducing the levels of SOD and MDA.]]> 2017/6/28 15:27:54 CAO Cong, HU Gao-yu, DENG Zhi-hua, et al 240true ［Abstract］　Objective　To compare the effects of kinesthetic motor imagery(KMI) and visual motor imagery(VMI) on lower limb motor function in the patients with cerebral infarction hemiplegia.Methods　Forty-two patients with cerebral infarction hemiplegia were randomly divided into KMI group(trained with KMI, n=21) and VMI group(trained with VMI, n=21). The conventional rehabilitation was conducted in both groups. Besides this, the KMI group was given KMI training and the VMI group was given VMI training. The scores of Fugl-Meyer motor assessment in lower extremity(FMA-LE) and the functional ambulation category scale(FAC) and the lower limb motor function were compared between the two groups at the time of admission and 3, 6 weeks after the treatment.Results　There was an increasing trend of FMA-LE and FAC scores in the lower limbs between the two groups 6 weeks after the treatment, and there was significant difference at each time points(P<0.05). FMA-LE and FAC scores of the KMI group were significantly higher than those of the VMI group 3 weeks after the treatment(P<0.05). There was no significant difference between the two groups 6 weeks after the treatment(P>0.05).Conclusion　KMI and VMI can improve the lower limb motor function in the patients with cerebral infarction hemiplegia. KMI has more advantages than VMI for the patients in the early stage of the disease.]]> 2017/6/28 15:27:54 ZHONG Lin 239true ［Abstract］　Objective　To explore the effect of strengthened rehabilitation education by caregivers on the hemiplegic shoulder pain in stroke patients.Methods　90 patients with hemiplegia were selected and were randomly divided into the observation group and the control group, with 45 cases in each group. The patients in the control group were treated with routine rehabilitation, and the patients in the observation group were treated with routine rehabilitation and the strengthened rehabilitation education that was given by the caregivers. The scores of the shoulder joint activity were evaluated by Fugl-Meyer assessment scale and the incidences of shoulder pain were calculated. The scores and the incidences were compared between the two groups.Results　After the intervention, the scores of the shoulder joint activity in the observation group were significantly higher than those in the control group(P<0.05), and the incidence of shoulder pain of the observation group was significantly lower than that of the control group(P<0.05).Conclusion　The strengthened rehabilitation education given by caregivers can reduce the hemiplegic shoulder pain and improve the shoulder joint activity in the hemiplegia patients.]]> 2017/6/28 15:27:54 HU Yu-jun, CHEN Qi-bo, HUANG Xiao-bei, et al 238true ［Abstract］　Objective　To compare the curative effects and hospitalization costs between conventional open thyroidectomy and endoscopic thyroidectomy in treatment of benign diseases of thyroid.Methods　Ninety-five patients with benign diseases of thyroid were divided into two groups according to the different surgical procedures. The endoscope group(n=55) received endoscopic thyroidectomy via mammary areola approach, and the conventional open thyroidectomy group(n=40) received traditional open thyoidectomy.Results　All the operations in both of the two groups were successful. Compared with the conventional open thyroidectomy group, the endoscope group had a higher rate of beauty satisfaction. The amount of bleeding during operation was less, the hospital stay was shorter and the hospitalization costs were higher in the endoscope group than those in the conventional open thyroidectomy group(P<0.01）. There were no severe complications during operation or after operation in both of the two groups.Conclusion　Endoscopic thyroidectomy via mammary areola approach has such advantages as higher rate of beauty satisfaction, less operative injury, faster recovery and shorter hospital stay in treatment of benign diseases of thyroid.]]> 2017/6/28 15:27:54 MO Kai-di, YANG Jian-rong, LI Bi-jin, et al 237true ［Abstract］　Objective　To investigate the clinical features and the efficacy of erythromycin on the patients with diffuse panbronchiolitis(DPB).Methods　12 patients with DPB who were treated with erythromycin from October 2010 to June 2015 were retrospectively analyzed. The clinical effects, radiological results, and laboratory parameters were analyzed, and the treatment course and the outcome of the treatment were recorded.Results　The mean age of the 12 patiens at symptom onset was （59.2±10.4）years, and the time from symptom onset to a correct diagnosis was （9.3±7.4）years. Chest computed tomography showed centrilobularmicronodules in 12 cases. Lung function test showed obstructive ventilator impairment in 12 cases and artery blood gas analysis showed hypoxemia in 12 cases. An elevated cold agglutinin titer was found in 1 case. 6 cases were misdiagnosed as COPD; 1 case was misdiagnosed as bronchial asthma; 4 cases were misdiagnosed as bronchiectasis and 1 case was misdiagnosed as miliary pulmonary tuberculosis. After the treatment of erythromycin, the clinical symptoms were improved in 10 cases, and 2 patients had a relapse and clinically improved after a second course of erythromycin treatment.Conclusion　DPB is apt to be misdiagnosed and should be paid more attention. Erythromycin is effective and well tolerated for the patients with diffuse panbronchiolitis.]]> 2017/6/28 15:27:54 QIN Shu-juan, CHEN Shu-ping 236true ［Abstract］　Objective　To compare the differences in the blood parameters of MCV, MCH and hemoglobin electrophoresis between the genotypes of thalassemia in Guangxi and to explore the correlation between the numerical differences and genotypes.Methods　α-thalassemia(deletion type) gene was detected by Gap-PCR method. α-thalassemia(non-deletion type) and β-thalassemia were measured by reverse dot blotting. Blood cell analysis was performed by a fully automated blood cell analyzer. The parameters of hemoglobin were measured by automatic capillary electrophoresis.Results　The results showed that MCV and MCH of α^QSα/αα genotype were the lowest in static α-thalassemia, and the hematology of --^SEA/αα genotype was the most serious in light α-thalassemia（P<0.05）. Light α-thalassemia and intermediate α-thalassemia HbA2 decreased, while light β-thalassemia and complex thalassemia HbA2 increased（P<0.05）. Hb CS band appeared only in genotypes containing CS point mutations such as α^CSα/αα, -α^3.7/α^CSα and --^SEA/α^CSα, but α^CSα/αα & β^CDs41-42 / β^N did not exhibit Hb CS bands（P<0.05）. In the intermediate α-thalassemia(hemoglobin H disease), --^SEA/α^CSα, --^SEA/-α^4.2 and --^SEA/-α^3.7 genotype hemoglobin electrophoresis results showed different degrees of Hb H, but the hemoglobin electrophoresis Hb H band was not found in the --^SEA/α^WSα（P<0.05）. The compound type of thalassemia(light α + light β) had milder anemia than the compound thalassemia(static type α + light β)（P<0.05）.Conclusion　The results of MCV, MCH and hemoglobin are relevant to the gene phenotypes,which is clinically significant to prevent and control thalassemia.]]> 2017/6/5 17:27:11 WANG Wen-jie, CHEN Fa-qin, WANG Lin, et al 235true ［Abstract］　Objective　To evaluate the diagnostic and therapeutic value and safety of double balloon enteroscopy(DBE) in small intestinal diseases.Methods　The data of 65 patients who underwent DBE for suspected small intestinal diseases were retrospectively analyzed.Results　Of the 65 cases,42 cases had been found lesions(64.6%), in which nonspecific intestinal inflammations were the first cause, followed by Meckal diverticula and tumors. The lesion detective rate of chronic abdominal pain was 54.2%. The rate of obscure gastrointestinal bleeding was 80.0%, The rate of incomplete intestinal obstruction was 90.9%, and the rate of unexplained diarrhea was 100.0%. Two cases occurred severe complications during the operation of DBE, in whom one had terminal ileum perforation, and the other had temporary decreased heart rate. No other complications occurred such as bleeding, pancreatitis and severe cardiovascular events.Conclusion　DBE is a valuable method of diagnosing small intestinal diseases, with the advantages of high safety and reliability.]]> 2017/6/5 17:27:11 LIU Xin, ZHANG Fa-can, NONG Bing, et al 234true ［Abstract］　Objective　To investigate the clinical effects of periodontal therapy and crown lengthening on the treatment of periodontal disease caused by unhealthy crown restoration of anterior.Methods　36 patients with periodontal disease were treated with the anterior crowns of the anterior teeth. The restorations in all the patients were not removed, but the basic periodontal therapy was performed on them. The gingival bleeding index, plaque index, probing depth and the degree of tooth looseness were compared before and after the treatment.Results　The gingival bleeding index, plaque index and probing depth after the treatment were significantly better than those before the treatment, P<0.01. There was no significant difference in tooth looseness before and after the treatment, P>0.05.Conclusion　Periodontal therapy and crown lengthening can improve the symptoms of periodontal disease, however the long-term curative effect remains to be observed.]]> 2017/6/5 17:27:11 LI Hui-jun, WU Min 233true ［Abstract］　Objective　To study the effect of periodontal treatment on the outcome of the patients with chronic periodontitis with occlusal trauma.Methods　77 patients with chronic periodontitis and occlusal trauma were selected and divided into the control group and the observation group according to the stratification. The control group（n=38） was treated with occlusal trauma teeth and adjustment in combination with full mouth scaling and root plane(SRP) for one month. The observation group（n=39） was treated with full mouth SRP, occlusal trauma teeth and adjustment for 1 month. The clinical indicators and the changes of the indexes of occlusion were compared between the two groups one month after the treatment.Results　After one month of the treatment,compared with those in the control group, the bleeding index, periodontal pocket depth and attachment level were significantly decreased; the occlusion time was significantly shortened and the occlusal force was significantly decreased in the observation group(P<0.05).Conclusion　Total SRP treatment can effectively shorten the duration of occlusion in the patients with periodontitis and occlusal trauma, and significantly improves the clinical symptoms of the patients.]]> 2017/6/5 17:27:11 ZHAO Qing-yang, LI Jian-min, ZHANG Xiao-dong, et al 232true ［Abstract］　Objective　To analyze the relationship between -592 site A/C polymorphism in interleukin 10(IL-10) gene and susceptibility to Henoch-Schonlein purpura(HSP) in children.Methods　The whole blood specimens of 112 HSP patients and 153 control subjects were collected and their genomic DNAs were extracted. The IL-10 592 site gene was analyzed by restriction fragment length polymorphism/polymerase chain reaction(RFLP/PCR), and the allele and genotype frequencies were compared between the HSP patients and the normal subjects.Results　No significant difference was found in IL-10 gene-592 C/A polymorphism between the HSP patients and the healthy controls(P>0.05).Conclusion　IL-10 gene-592 C/A polymorphism has no association with susceptibility of HSP in children.]]> 2017/6/5 17:27:11 YU Yan-juan, ZHANG Xiang-feng, CHANG Hui-juan, et al 231true ［Abstract］　Objective　To explore the feasibility of preoperative planning and intraoperative guidance in the light of pancreas and stomach vascular 3D image based on computed tomography(CT) data.Methods　From March 2016 to November 2016, 4 patients with gastric cancer were scanned by 64 slice spiral CT. The CT data were collected, and the celiac trunk and its branches were reconstructed to three dimensional image automatically by self-developed liver CAD software. The CT data of pancreas and portal vein with its branches were segmented and reconstructed to three dimensional image manually. Then, it was set up that the three dimensional image of celiac trunk with its branches and the portal vein with its branches and the pancreas which was located in the center. The preoperative plannings and intraoperative guidances for gastric cancer surgery were performed based on the three dimensional image.Results　The 4 patients were successfully reconstructed the three dimensional image of celiac trunk with its branches and the portal vein with its branches and the pancreas which was located in the center. Vascular anatomical variations were found in one case from these images, in which the termination of the left gastric vein was joined directly in portal vein. The preoperative plannings and intraoperative guidances for gastric cancer radical surgery were performed successfully based on the three dimensional image in all the patients. 4 cases of them were operated on successfully with no intraoperative massive haemorrhage and other complications such as ligating blood vessels by mistake. The operation time was 260～330 minutes, and the intraoperative blood loss was 50～400 ml. The postoperative hospitalization time was 7～12 days.Conclusion　The three dimensional image of celiac trunk with its branches and the portal vein with its branches and the pancreas which is located in the center, can help the surgeons understand the anatomical condition of celiac trunk with its branches and the portal vein with its branches, and guide the surgeons to clear the lymph nodes during the operation.]]> 2017/6/5 17:27:11 WU Dong-bo, ZHANG Xue-jun, MA Long-bai, et al 230true ［Abstract］　Objective　To compare the efficacy and safety between intravesical instillation chemotherapy by hydroxycamptothecin and by pirarubicin for treatment of the recurrence of bladder cancer after transurethral resection of non-muscle invasive bladder cancer(NMIBC).Methods　Seventy-six patients with non-muscle invasive bladder cancer were divided into the hydroxycamptothecin group(n=38) and the pirarubicin group(n=38) by random number table. The hydroxycamptothecin group received regular intravesical instillation of hydroxycamptothecin and the pirarubicin group received regular intravesical instillation of pirarubicin one week after transurethral resection of bladder cancer. The recurrence rate of bladder cancer, adverse reactions and the costs of chemotherapy were compared between the two groups.Results　The patients received a follow-up of 12～60 months.The one-year-recurrence rate of the hydroxycamptothecin group was higher than that of the pirarubicin group(P<0.05), but there was no significant difference in the total recurrence rate between the two groups after a follow-up of 12～60 months(P>0.05). The incidence of bladder irritation in the hydroxycamptothecin group was lower than that in the pirarubiein group(P<0.05).Conclusion　Both hydroxycamptothecin and pirarubicin can be effective in preventing postoperative recurrence of NMIBC. Compared with hydroxycamptothecin, pirarubicin has a better short-term curative effect, but a higher incidence of adverse reactions and higher costs.]]> 2017/6/5 17:27:11 LONG Jun, LIN Hai-song, MO Zeng-nan, et al 229true ［Abstract］　Objective　To explore the clinical effect of radiotherapy combined with low-dose nedaplatin chemotherapy in treatment of elderly patients with esophageal cancer.Methods　124 elderly patients with advanced esophageal cancer were selected as the study subjects and by the random number table method, they were divided into group A(n=40, treated with radiotherapy alone), group B ［n=42, treated with radiotherapy combined with low-dose(20 mg/m²) nedaplatin chemotherapy］ and group C［n=42, treated with radiotherapy combined with high-dose(30 mg/m²) nedaplatin chemotherapy］. The short-term effects and the incidence of side effects were compared among the three groups two months after the treatment.Results　The short-term curative effect of group B was the best, followed by group C, and the effect of group A was the worst(P<0.05). There were significant differences in the incidence rates of Ⅰ～Ⅱ level and Ⅲ～Ⅳ level of nausea or vomiting, Ⅰ～Ⅱ level of radiation-induced pneumonia and Ⅰ～Ⅱ level of radioaction esophagitis between the groups(P<0.05), and the incidence rates of group C were significantly higher than those of group B and group A(P<0.05); The incidence rates of Ⅲ～Ⅳ level of anorexia and Ⅲ～Ⅳ level of radioaction esophagitis and Ⅲ～Ⅳ level of myelosuppression in group C were significantly higher than those in group A(P<0.05), and the incidence rates of Ⅲ～Ⅳ level of anorexia and Ⅲ～Ⅳ level of myelosuppression in group B were significantly higher than those in group A(P<0.05). The side effects of group A and group B were Ⅰ～Ⅱ level, and after symptomatic treatment, the symptoms were significantly alleviated.Conclusion　Compared with those of radiotherapy alone and radiotherapy combined with high-dose nedaplatin chemotherapy, the effect of radiotherapy combined with low-dose nedaplatin is safer and more significant in the treatment of elderly patients with esophageal cancer.]]> 2017/6/9 8:58:44 GUO Wei-hua, DUAN Ren-hui 228true ［Abstract］　Objective　To evaluate the clinical effects of intravenous injections of amiodarone and verapamil on the treatment of paroxysmal supraventricular tachycardia（PSVT）.Methods　Medical articles of randomized controlled trials published in Chinese and English about the treatment of PSVT were searched in the Cochrane library and on the databases of PubMed, EMBASE, CNKI, VIP and Wangfang from January 2005 to December 2015, with a strictly screening according to the standard of assessing the quality of the literatures. The data of the selective trials were analyzed by the RevMan 5.20 software.Results　A total of ten randomized clinical trials were included. The Meta-analysis showed that there was no significant difference between the amiodarone group and the verapamil group in the curative effect of PSVT(OR=0.73，95%CI=0.35～1.53，P=0.41); The incidence of adverse reactions of the amiodarone group was significantly lower than that of the verapamil group(OR=0.34, 95%CI=0.21～0.57, P<0.01); The cardioversion time of PSVT in the verapamil group was significantly shorter than that in the amiodarone group(OR=7.90, 95%CI=3.35～12.44, P<0.01).Conclusion　Amiodarone is more safe and reliable than verapamil in the treatment of PSVT. The cardioversion time of amiodarone is longer than that of verapamil.]]> 2017/6/9 8:58:44 HOU Chuan-xing, HUANG Shao-xiang, TAO Zhi-yue 227true ［Abstract］　Objective　To compare the clinical effect between progesterone and flexor progesterone on the patients with early threatened abortion.Methods　100 patients with early threatened abortion were collected and were randomly divided into the observation group(flexor progesterone) and the control group(progesterone) according to the different treatments. The curative effect, the abortion rate, the symptoms disappear time, the incidence of adverse reactions and the levels of estradiol(E2) and blood human chorionic gonadotropin(HCG) were compared between the two groups before and after the treatment.Results　The E2 of the observation group was significantly higher than that of the control group two days after the treatment(P<0.01). The levels of blood HCG in both of the two groups fours days after the treatment were significantly higher than those before the treatment(P<0.05), however there was no significant difference between the two groups after the treatment(P>0.05). The clinical symptom disappear time of the observation group was significantly shorter than that of the control group(P<0.01). The clinical effect of the observation group was slightly higher than that of the control group, without a statistically significant difference(P>0.05). There was no statistically significant difference in the spontaneous abortion rate between the two groups(P>0.05). The adverse reaction rate of the control group was significantly higher than that of the observation group(P<0.05).Conclusion　Flexion progesterone and progesterone have a similar clinical effect on the treatment of early threatened abortion but flexion progesterone is safer and more convenient than progesterone.]]> 2017/6/9 8:58:44 WU Ting-ting, LI Xiao-fang 226true ［Abstract］　Objective　To observe the values of procalcitonin(PCT) and C-reactive protein(CRP) and APACHE Ⅱ scores in evaluating the prognosis of the septic shock patients.Methods　The peripheral serum levels of PCT and CRP, and APACHE Ⅱ scores were retrospectively analyzed in 45 patients with septic shock at the first, the third and the fifth day after admission to the hospital and the last day of staying at the hospital. The patients were divided into the survival group(n=20) and the death group(n=25) according to the outcomes of their prognoses. APACHE Ⅱ scores and the levels of PCT and CPR were compared between the two groups.Results　 Twenty-five cases survived and 20 cases died. APACHE Ⅱ sores were significantly higher in the death group than those in the survival group［(28.84±8.03） vs （21.82±7.10)］. There were no significant differences in PCT and CRP at the first and the third day after admission to the hospital between the two groups, however, PCT and CRP of the death group were significantly higher than those in the survival group. With the extension of the observation time, PCT and CRP were obviously decreased in the survival group. Nevertheless, the changes of them were not significant in the death group.Conclusion　Persistently high levels of serum CRP and PCT indicate the poor prognoses in septic shock patients.]]> 2017/6/9 8:58:44 JIANG Ling-yu, XIONG Bin, HAN Lin, et al. 225true ［Abstract］　Objective　To investigate the expressions of WW domain containing oxidoreductase(WWOX) in the normal breast and breast cancer tissues.Methods　The expression of WWOX was detected immunohistochemically in the normal breast tissue, fibroadenoma, breast carcinoma in situ and invasive breast cancer.Results　The expressions of WWOX in the normal breast tissue and fibroadenoma were significantly higher than those in carcinoma in situ and invasive breast cancer(P<0.01).Conclusion　WWOX can be considered as a tumor suppressor gene. The decrease of WWOX expression and delete of WWOX in breast cancer imply that it plays an important role in the pathogenesis and progression of breast cancer.]]> 2017/6/9 8:58:44 LIAN Ling-zhi, GU Feng-hua, GU Guo-jian 224true ［Abstract］　Objective　To explore the clinical effect of total hip replacement on the treatment of femoral intertrochanteric fracture complicated with femur head necrosis.Methods　Nineteen patients with femoral intertrochanteric fracture complicated with femur head necrosis were treated with total hip replacement in our department between July 2010 and May 2015, and their clinical efficacy were evaluated.Results　All the patients got bone union, fracture healing and prosthesis in good position, after a follow-up of 10～25 months, with an average of 15.4 months. In accordance with the criteria for assessing the efficacy of Harris, the clinical effect was excellent in 8 cases, good in 9 cases, improved in 2 cases, with an effective rate of 89.5%.Conclusion　Total hip replacement avoids the second surgery, reduces complications, and therefore is an ideal treatment for femoral intertrochanteric fracture complicated with femur head necrosis.]]> 2017/6/14 10:41:48 GUO Jia-rui, YU Jin-wei, CHEN Xu 223true ［Abstract］　Objective　To explore the clinical effect and safety of liraglutide combined with metformin in the treatment of patients with type 2 diabetic and obesity.Methods　Sixty-two patients with type 2 diabetes and obesity in our hospital from June 2013 to May 2015 were selected and randomly divided into the observation group and the control group, with 31 cases in each group. The control group was given metformin, while the observation group was given liraglutide combined with metformin. The level of blood glucose, weight control condition and adverse reactions were compared between the two groups 12 weeks after the treatment.Results　Before the treatment, there were no significant differences in the clinical indexes between the two groups(P>0.05). After the treatment, FPG, 2hPG, HbA1c, waist-to-hip ratio and BMI of the patients in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group(9.68%) and the control group(6.45%)(P>0.05). Both of the two groups had no severe reactions.Conclusion　Liraglutide combined with metformin is safe and effective for the patients with type 2 diabetes and obesity.]]> 2017/6/14 10:41:48 LIU Xiang-ru, LI Yue, HU De-long 222true ［Abstract］　Objective　To observes the therapeutic efficacy of uterine artery embolization combined with methotrexate infusion in the treatment of cesarean scar pregnancy(CSP) and to analyze three factors related to failure of the treatment.Methods　Thirty-six CSP patients were treated with uterine artery embolization combined with MTX infusion. Among them six patients with severe hemorrhage were immediately performed the interventional operation. The clinical effects were evaluated by the improvement of symptoms, serum β-hCG, ultrasound and MR.Results　The interventional treatment was technologically successful in 34 patients. Immediate hemostasis was achieved in 6 patients with massive colporrhagia. No occurrence of infection and uterine necrosis was observed. 16 women suffered abdominal pains. 33 patients′ uteri were preserved, while 3 underwent hysterectomy eventually.Conclusion　Transcatheter arterial chemoembolization is effective to treat high-risk CSP. The three factors including adequate MTX dosage, appropriate embolic materials, and complete embolization of the target arteries that supply blood to embryo in the scar are the key points of the successful therapy.]]> 2017/6/14 10:41:48 LIAO Hua-zhi, TANG De-qiu, LIU Wen-wen, et al. 221true ［Abstract］　Objective　To research the effects of different intensities of exercise rehabilitation and to provide the theoretical basis for carrying out early rehabilitation exercise in the patients with angina pectoris.Methods　120 patients in our hospital from May 2014 to May 2016 were randomly divided into three groups. The control group（n=40） was given the routine oral treatment of antithrombotic, lipid-lowering and vasodilation drugs. The moderate intensity exercise rehabilitation group（n=40）, on the basis of above regular treatment, received the moderate rehabilitation exercise. The high intensity exercise rehabilitation group（n=40）, received the high strength and rehabilitation exercise on the basis of the above regular treatment. All patients were treated for six weeks. At the end of the treatment, Seattle Angina Questionnaire was assessed in five dimensions to evaluate the curative effect of ECG.Results　After the treatment, the levels of limited physical activity, the stability of angina, the occurrence rate of the satisfaction of treatment, the understanding of the disease, and the myocardial ischemia degree of ECG in the rehabilitation exercise groups were improved better than those in the control group, and those in the high intensity exercise rehabilitation group were improved more obviously than those in the moderate intensity exercise rehabilitation group(P<0.05).Conclusion　Exercise rehabilitation is effective to improve ECG and the quality of life in the patients with angina pectoris, and the degree of improvement is positively related to the intensity of exercise.]]> 2017/6/14 10:41:48 KOU Min-sheng, GENG Li-qun 220true ［Abstract］　Objective　To explore the relationship between psychological factors and the levels of NPSR1, CGRP and IL-6 in patients with peripheral blood plasma of functional dyspepsia(FD).Methods　One hundred and thirty-six FD patients were divided into PDS group(n=77) and EPS group(n=59). During the same period of the treatment 40 healthy people without FD and other disease were collected as the control group. The related data were recorded by using Self-Rating Depression Scale(SDS) and Self-Rating Anxiety Scale(SAS). The anxious and depressive symptoms were compared among the PDS, EPS and the control group. The anxious and depressive symptoms were compared between the PDS and EPS groups. The levels of NPSR1, IL-6 and CGRP were detected using ELISA. The relationship between the levels of NPSR1, IL-6 and CGRP and the patients′ anxious and depressive symptoms was analyzed.Results　The scores of anxiety in the PDS group and the EPS group were higher significantly than the those in the control group(P<0.01). The scores of anxiety in the PDS group were significantly higher than those in the EPS group(P<0.01). In the PDS group, the scores of SAS were positively related to the scores of SDS(P<0.05). In the FD group, the level NPSR1 was negatively related to the scores of anxiety(P<0.01). In the PDS group, the level of NPSR1 was negatively related to the scores of anxiety(P<0.05).Conclusion　The psychological factors are positively related to the occurrence of FD. NPSR1 plays an important role in the regulation of anxiety in FD patients.]]> 2017/6/22 9:55:21 HUANG Geng-zhen, HE Guo-bin, ZHOU Xiao-qing, et al. 219true ［Abstract］　Objective　To compare the clinical effects and safety between oxaliplatin(L-OHP) and paclitaxel(PTX) respectively combined with 5-fluorouracil(5-Fu) chemotherapy on the patients with gastric cancer after radical resection.Methods　Sixty-six patients who underwent radical resection of gastric cancer were selected as the study subjects. They were numbered in the order of admission, and were randomly divided into group A and group B, with 33 cases in each group. The group A was treated with L-OHP combined with 5-Fu adjuvant chemotherapy, while the group B was treated with PTX combined 5-Fu. Both of the two groups were followed up for 2 years. The tumor recurrence rate, metastasis rate, tumor-free survival rate, overall survival rate and incidence of toxic and side effects were compared between the two groups.Results　There were no significant differences in postoperative 1-year or 2-year tumor recurrence and metastasis rate between the group A and the group B(P>0.05); There were no differences in postoperative 1-year or 2-year disease-free survival rates and overall survival rates between the group A and the group B(P>0.05); The incidences of grade Ⅲ～Ⅳ neutropenia, nausea and vomiting, peripheral nerve toxicity, fever and abnormal liver function in the group A were slightly higher than those in the group B but there were no significant differences between the two groups(P>0.05).Conclusion　L-OHP and PTX respectively combined with 5-Fu in adjuvant chemotherapy are both safe and effective in the treatment of gastric cancer after radical resection.]]> 2017/6/22 9:55:21 BIAN Jun-jie, TIAN Guo-fang 218true ［Abstract］　Objective　To explore the relationship between insulin resistance and high-sensitive C-reactive protein, serum uric acid and lipid metabolism in the patients with type 2 diabetes mellitus(T2DM).Methods　One hundred and forty-eight patients with T2DM were selected.The levels of fasting plasma glucose(FPG), 2-hour plasma glucose(2h PG), fasting insulin(Fins), serum uric acid(SUA), high-sensitive C-reactive protein(hs-CRP), high density lipoprotein cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), total cholesterol(TC) and triglycerides(TG) were determined. The research subjects were divided into four groups according to the quartiles of HOMA-IR′s results. The results of all the items were compared among the four groups.Results　The levels of hs-CRP, SUA, TG, HDL-C were significantly different among the four groups(P<0.05). The Pearson analysis showed that HOMA-IR was positively correlated with hs-CRP, SUA and TG, and was negatively correlated with HDL-C（P<0.05） The hs-CRP, SUA and HDL-L were entered the multiple linear regression analysis, and the equation was y=53.284+0.237X₁+0.098X₂-1.618X₃.Conclusion　There is a significant relationship between hs-CRP, SUA and HDL-L with IR in the patients with type 2 diabetes mellitus.]]> 2017/6/22 9:55:21 LIU Ling-xia 217true ［Abstract］　Objective　To assess the application of esophageal stent implantation of proximal release in the treatment of malignant esophageal stricture.Methods　Twenty patients with malignant esophageal stricture were implanted esophageal stent by proximal release under endoscopy.Results　Twenty patients were implanted successfully in one time and the success rate was 100%. The dysphagia scores reduced from (3.58±0.22)points to (1.10±0.28)points(P<0.05).Conclusion　Implantation of esophageal stents by proximal release is simple, safe, and effective for the patients with malignant esophageal stricture.]]> 2017/6/22 9:55:21 YANG Ting-xu, WANG Hai-xia 216true ［Abstract］　Objective　To analyze the effect of hybrid surgery on multilevel cervical myelopathy.Methods　Thirty-seven cases with multilevel cervical spondylosis in our department from April 2011 to May 2013 were performed anterior cervical fusion combined with non-fusion hybrid procedure(group A), and simple anterior cervical fusion group(group B). The scores of pre-and-postoperative JOA and NDI, ROM of adjacent segments of the cervical spine and the total ROM of the proposed operation segments were compared between the two groups after a follow-up of 2.5 years.Results　After the follow-up of 2.5 years, there were significant differences in JOA scores and its improvement rate, NDI scores, the total activity of the cervical spine, axial symptoms, and pre-and-postoperative adjacent segmental ROM and total ROM between group A and group B(P<0.05).Conclusion　Hybrid surgery retains a certain degree of activity segments, adjacent segments to avoid the stress load increases due to excessive compensation, which is an effective method for treating multiple segments cervical spinal cord disease.]]> 2017/6/30 9:13:09 GUO Yong-chuan,ZHANG Yi-hong,MA Shou-zhan,et al. 215true ［Abstract］　Objective　To explore the clinical effect of orthopedic suture techniques on stage Ⅰ repair of facial trauma applied.Methods　The clinical data of 90 cases in our hospital with facial trauma were retrospectively analyed. The control group(n=45) was treated with conventional surgical debridement treatment, and the observation group(n=45) was treated with plastic surgery suture technique on the basis of the same treatment in the control group. The clinical effect was compared between the two groups.Results　The operative time, blood loss, wound healing time and hospital costs were significantly lower in the observation group than those in the control group, and the clinical efficacy of wound healing was significantly better in the observation group than that in the control group, P<0.01.Conclusion　Plastic surgical suture technique is effective in the treatment of facial trauma.]]> 2017/6/30 9:13:09 CHEN Yao, GU Han-nan, ZHANG Zi-qing 214true ［Abstract］　Objective　To investigate the effectiveness and safety of tranexamic acid(TXA) on reducing blood loss during the intraoperative period in elderly patients who underwent primary unilateral bipolar artificial femoral head replacement.Methods　Sixty patients who were scheduled to receive primary unilateral bipolar artificial femoral head replacement were randomly divided into the TXA group(n=30) and the control group(n=30). The TXA group received intra-anicular injection of 3 g tranexamic acid with 50 ml physiological saline, the control group received the same volume of physiological saline injection after the incision was closed. Drainagetube was clamped for 2 hours. The total blood loss, transfusion rate, the incidence of deep vein thrombosis(DVT), pulmonary embolism(PE), the postoperative drainage, intraoperative blood loss, hidden blood loss and complications were compared between the two groups.Results　The total blood loss, postoperative drainage, hidden blood loss and blood transfusion rate in the TXA group were significantly less than those in the control group(P<0.05). No PE and DVT occurred in the two group.Calfmuscular venous thrombosis was found in 3 cases in the TXA group and 4 pations in the control group, without a significant difference between the two groups(P>0.05).Conclusion　Intra-articular injection of tranexamic acid is safe and effective in the treatment of blood loss in elderly patients with bipolar artificial femoral head replacement.]]> 2017/6/30 9:13:09 GAN Feng-ping, JIANG Jian-zhong, TAN Hai-tao, et al. 213true ［Abstract］　Objective　To evaluate the efficacy and safety of home-produced tirofiban during primary percutaneous coronary intervention(PCI) for patients with diabetic mellitus(DM) and acute myocardial infarction(AMI) in China.Methods　The randomized controlled trials on intervention therapy of DM and AMI with home-produced tirofiban were retrieved by computer. A total of 19 studies were enrolled, including 2 025 patients, in which the tirofiban group contained 1 010 cases and the routine therapy group contained 1 015 cases. Rev-Man 5.3 software was used for meta-analysis.Results　Compared with those in the control group, thrombolysis in myocardial infarction(TIMI) Ⅲ flow was improved［RR=1.22,95%CI(1.07, 1.39), P=0.002］; lower incidence of major adverse cardiac events was in the patients during hospitalization and 30 days after PCI ［RR=0.4, 95%CI(0.31, 0.51), P<0.00001; RR=0.36, 95%CI(0.29, 0.45), P<0.00001］; left ventricular ejection fraction(LVEF) was increased［WMD=0.84, 95%CI(0.40,1.28), P=0.0002; WMD=6.25, 95%CI(5.25, 7.26), P<0.00001］ in the patients one week and 30 days after PCI; lower serum BNP ［WMD=-53.07,95%CI(-70.69,-35.45),P<0.00001; WMD=-50.10, 95%CI(-60.16, -40.05), P<0.00001］ was in the patients 7 days and 30 days after PCI and the incidence of bleeding was higher in the tirofiban group［RR=2.04, 95%CI(1.40, 2.96), P=0.0002］. No severe bleeding occurred in both of the two groups. There was no significant difference in bleeding events between the two groups［RR=0.90, 95%CI(0.65, 1.26), P=0.54］ during 30 days after PCI.Conclusion　Home-produced tirofiban has significant therapeutic effects on interventional therapy of DM and AMI in Chinese population and has a low incidence of adverse reactions.]]> 2017/6/30 9:13:09 MA Chun-lan, WANG Hong, WU Chong-xin, et al. 212true ［Abstract］　Objective　To investigate the clinical effect of enalapril combined with metoprolol on treating chronic congestive heart failure.Methods　One hundred and twenty cases with chronic congestive heart failure in our hospital from June 2012 to March 2016 were selected and divided into the observation group and the control group by means of random number table, with 60 cases in each group. The control group was given conventional treatment(enalapril) and the observation group was given enalapril combined with metoprolol and the treatment course was three months. The clinical effect was comparal between the two groups.Results　The effective rate of the observation group was significantty higher than that of the control group(P<0.05). SV, CO, LVEF and LVDd were improved significantly after the treatment compared with those before the treatment in both of the two groups(P<0.05).Conclusion　Enalapril combined with metoprolol is markedly effective in treating chronic congestive heart failure.]]> 2017/6/30 9:13:09 HOU Yu-yan, WANG Zhi-fang, LIU Zhi-qiang, et al. 211true ［Abstract］　Objective　To study the correlation between the level of serum homocysteine(Hcy) and the severity of coronary stenosis.Methods　Eighty-four patients who were clinically suspected with coronary heart disease（CHD） from April 2013 to December 2014 were chosen as the research subjects. All the patients received coronary angiography and Hcy examination, and the relationship between CHD and serum Hcy was analyzed.Results　The levels of Hcy in the normal group were significantly lower than those in the groups with different degrees of coronary stenosis(P<0.05). The level of Hcy increased with the rising degree of coronary artery stenosis(P<0.05). The levels of serum Hcy were positively correlated with the Gensini scores of coronary stenosis(r=0.835)(P<0.05).Conclusion　The levels of serum Hcy are positively correlated with the degrees of coronary stenosis, which can be used as an important index to predict the severity and prognosis of CHD.]]> 2017/12/22 10:21:37 HUANG Bin, LI Xing-yang, PAN Feng-xia, et al. 210true ［Abstract］　Objective　To study the relationship between the shape of femoral condyle and the gap of flexion and extension after total knee arthroplasty(TKA) by standard osteotomy.Methods　Seventy-six patients who were diagnosed as osteoarthritis and treated by TKA were enrolled in this study. The medial-lateral diameter and anteroposterior diameter of the femoral condyle were measured according to the preoperative knee X-ray radiographs. The gaps of flexion and extension were measured after TKA by standard osteotomy. The patients with flexion gap more than extension gap were taken as group A, those with flexion gap equal to extension gap as group B, and those with flexion gap less than extension gap as group C. The ratio of medial-lateral diameter to anteroposterior diameter of the femoral condyle, the KSS scores and knee flexion were compared among the three groups after surgery.Results　There were significant differences in the ratio of medial-lateral diameter to anteroposterior diameter of the femoral condyle before surgery(P<0.05). There were no significant differences in the postoperative KSS scores and the knee joint activity among the three groups after surgery(P>0.05). Postoperative improvements of the KSS scores and knee activity degree were achieved in all groups.Conclusion　The ratio between medial-lateral diameter and anteroposterior diameter is related to the size of the flexion and extension space. When the ratio is larger, the flexion gap will be more than extension gap, and when the ratio is smaller, the extension gap will be more than flexion gap. The knee function becomes better after intraoperative adjustment.]]> 2017/12/22 10:21:37 LIU Xiang-lin, LV Yong-ming, XU Cong, et al. 209true ［Abstract］　Objective　To compare the accuracy and clinical value of Zeiss IOL Master and A-ultrasound in measuring intraocular lens degree.Methods　One hundred and sixteen patients with cataracts(119 eyes) were collected in our hospital from January 2014 to September 2015 and their eye parameters were measured by Zeiss IOL Master and A-ultrasonography before operation. The intraocular lens degrees were implanted by SRK-T formula, and the patients were divided into the long axis group(L>26 mm), the short axis group(L≤22 mm) and the normal axial group(22 mmResults　The ocular axial length measured by IOL Master was longer than that measured by A-ultrasound（P<0.05）. There was no significant difference in MAE between IOL Master and A-ultrasonography(P>0.05). There were no significant differences in the percentages of MAE≤0.50 D, MAE≤1.00 D and MAE≤2.00 D of IOL Master and A-ultrasound measured postoperatively(P>0.05).Conclusion　Compared with the ordinary A-ultrasound, Zeiss IOL Master has higher accuracy, more convenience and a higher clinical value in the measurement of intraocular lens.]]> 2017/12/22 10:21:37 WANG Shi-yi 208true ［Abstract］　Objective　To evaluate the short-term efficacy and safety of radiofrequency hyperthermia combined with chemotherapy in the treatment of advanced gastrointestinal cancer,and to analyze the effect of radiofrequency hyperthermia and chemotherapy on the symptoms of digestive tract and serum tumor markers.Methods　Eighty-two patients with malignant gastrointestinal tumors were collected in our hospital from May 2014 to December 2015, and were randomly divided into the control group(n=41) and the observation group(n=41). The control group was given conventional chemotherapy treatment, and the observation group received the same treatment as the control group plus radiofrequency hyperthermia therapy. Both of the two groups were treated for 4 weeks for 1 course. The clinical efficacy, the improvement of gastrointestinal symptoms,the changes of serum levels of tumor markers and the incidence of complications were compared between the two groups 3 courses after the treatment.Results　The curative effect of the observation group was better than that of the control group(P<0.05). Compared with those before treatment, the scores of losing appetite, nausea and vomiting were significantly lower after treatment in both of the two groups(P<0.05 or P<0.01), however, there were no significant differences in these scores between the two groups after treatment. After treatment, the levels of serum CEA, CA125, CA19-9 and CA72-4 in the two groups were significantly lower than those before treatment(P<0.01). There was no significant difference in the incidence of adverse reactions such as neurotoxicity, leukopenia, gastrointestinal reaction and liver function damage between the two groups after treatment(P>0.05).Conclusion　Radiofrequency hyperthermia combined with chemotherapy can significantly improve the gastrointestinal symptoms, effectively reduce the levels of serum tumor markers but does not increase the adverse reactions in the patients with gastrointestinal cancer, which has significant synergies and better clinical effect than chemotherapy alone.]]> 2017/12/22 10:21:37 ZHAO Sheng-nan, XIA Xing-zhou, SI Yuan-fang, et al. 207true ［Abstract］　Objective　To study the clinical efficacy and safety of compound lactobacillus acidophilus combined with quadruple therapy on helicobacter pylori(Hp) infection.Methods　Two hundred and twenty-four patients with Hp infection were collected from March 2014 to September 2016 and were divided into two groups. The control group(n=112) received a quadruple therapy to eradicate Hp, after the application of omeprazole acid treatment; the observation group(n=112) was treated with compound lactobacillus acidophilus plus the same treatment as the control group. The clinical effect, Hp eradication rate and adverse drug reactions(ADR) were compared between the two groups.Results　In the observation group, 52 cases were cured, 54 cases effective and 6 cases ineffective. In the control group, 42 cases were cured, 46 cases effective and 24 cases ineffective. The clinical effect of the observation group was better than that of the control group(P<0.05). Compared with those before treatment, the scores of clinical symptoms in both of the two groups were lower after treatment(P<0.05), but the scores of the observation group were low more obviously than those of the control group(P<0.05). The incidence of ADR in the observation group(3.6%) was significantly lower than that in the control group(17.9%)(P<0.05). There was no significant difference in the eradication rate of Hp between the observation group(92.9%) and the control group(85.7%)(P>0.05).Conclusion　Compound lactobacillus acidophilus combined with quadruple therapy is safe and effective in the treatment of Hp infection.]]> 2017/12/22 10:21:37 HU Wei-lin 206true ［Abstract］　Objective　To analyze the therapeutic effect of papillary thyroid carcinoma(PTC) and the characteristics of lymph node metastasis to the central area.Methods　The clinical data of 201 patients with PTC in our hospital were retrospectively analyzed. The factors including age, sex, tumor size, capsule status and tumor staging were analyzed statistically, and the influencing factors of lymph node metastasis to the central area were analyzed.Results　The 201 patients underwent individualized surgical treatment among whom the TNM stage Ⅰ was found in 108 cases, stage Ⅱ in 43 cases, stage Ⅲ in 42 cases and stage Ⅳ in 8 cases. There was no death during the perioperative period. Rare complications occurred postoperatively. There were no pneumothorax, chylous fistula, tracheo-esophageal fistula, perpetual hypoparathyroidism and injury of recurrent laryngeal nerve. Transient hypocalcemia occurred in 2 cases during hospitalization. All the patients were followed up for 6 months to 5 years and local recurrence occurred in 2 cases, lymph node metastasis in 2 cases, and distant metastasis in 1 case, with 53.7% of (108/201) lymph node metastasis to the central area and 64.8% of (70/108) lymph node metastasis to the lateral cervical region. Logistic regression analysis showed that TNM stages and tumor penetrating membrane were the risk factors of lymph node metastasis to the central area.Conclusion　Individualized treatment should be performed on the patients with PTC according to their different clinical features. Lymph node dissection is necessary for the patients whose incidence of lymph node metastasis to the central area is high. In the patients with lymph node metastases to the central region, lateral cervical lymph node dissection is recommended.]]> 2017/12/22 10:21:37 PANG Fei-xiong, ZHANG Jia-yue, LENG Jin-li, et al. 205true ［Abstract］　Objective　To analyze the correlation between hepatitis C virus RNA(HCV-RNA) and liver function and blood indexes in patients with hepatitis C virus(HCV).Methods　The blood samples were collected from 165 patients with HCV and 40 healthy people, whose serum quantity HCV-RNA was detected by PCR-flurescence and whose liver function and blood analysis were detected by automation instrument. The results were compared between the two different groups of the people.Results　The levels of albumin(ALB), leukocytes counts(WBC), neutrophils counts(NEUT) and neutrophil ratio(NEUTR) in the HCV patients were significantly lower than those in the healthy people, lymphocytes ratio(LYR) and the level of alanine(ALT) in the HCV patients was significantly higher than that in the healthy people(P<0.01). There were no significant differences in the levels of ALB and blood indexes between different groups of the people with different quantities of HCV-RNA(P>0.05). The level of ALT increased with the quantity of HCV-RNA rising(P<0.05).Conclusion　The level of ALT is correlated with the quantity of HCV-RNA, while ALB and blood indexes are not correlated with the quantity of HCV-RNA.]]> 2017/12/22 10:21:37 LIU Wen-jun, YANG Xia-fang, ZHONG Qiu-lian, et al. 204true ［Abstract］　Objective　To explore the value of T cell enzyme-linked immuno-spot assay(T-SPOT.TB) on peripheral blood and different thresholds in the diagnosis of tuberculous pleurisy and non- tuberculous pleurisy.Methods　A total of 40 cases were enrolled in this study among whom 16 cases were classified as pathologically diagnosed tuberculous pleurisy, and the other 24 cases were classified as clinically diagnosed tuberculous pleurisy. Other 13 cases with non- tuberculous pleurisy were taken as the control group. The peripheral blood of all the patients was tested by T-SPOT.TB and the results were analyzed by SPSS 19.0 according to the spot forming cells(SFCs).Results　Compared with that in non- tuberculous pleurisy, the positive rate of T-SPOT.TB in tuberculous pleurisy was higher(23.1% vs 85.0%, P<0.01). The SFCs of peripheral blood antigen A（ESAT-6 antigen） and antigen B（CFP-10 antigen） were greater in the tuberculous pleurisy group［15.2（0～110）/10⁶ and 52.0（0～200）/10⁶, respectively］ than those in the non- tuberculous pleurisy group［0.5(0～40) /10⁶ and 1.0(0～52）/10⁶, respectively］（P<0.05）. In tuberculous pleurisy, the areas under the receiver operating characteristic(ROC) curve(AUS) of ESAT-6 and CFP-10 were 0.842 and 0.880, respectively. In addition, AUC 95% confidence intervals were （0.782～0.967） and (0.771～0.977), respectively(P<0.05). Different cut-off points of Jouden Index were used to classify ESAT-6 antigen and CFP-10 antigen thresholds in the diagnosis of tuberculous pleurisy. If ESAT-6 antigen diagnosis cut-off value was weakly positive（6/10⁶ 6）, the specificity was 92.3%. However, if it was strongly positive（SFC≥48.5/10⁶）, the specificity was 100.0%. For CFP-10 antigen, if there was（6/10⁶ 6）, the specificity was 84.6%. However, if it was strongly positive（SFC≥57/10⁶）, the specificity was 100.0%. The weakly positive rates of ESAT-6 antigen and CFP-10 antigen were no significantly different between the pathological diagnosed groups and the clinically diagnosed groups. However, compared with those in the clinically diagnosed groups, the strongly positive rates of ESAT-6 antigen and CFP-10 antigen were greater than those in the pathological diagnosed groups.Conclusion　Peripheral blood T-SPOT.TB can improve the diagnostic performance for tuberculous pleurisy. The SFC values of ESAT-6 antigen and/or CFP-10 in high cut-off level indicate that tuberculosis infection is active. It is of great value and significance to detect the different threshold values and SFC of ESAT-6 antigen and/or CFP-10 antigen in the diagnosis of tuberculous pleurisy.]]> 2017/12/22 10:21:37 LIANG Da-hua, LIU Hang, WEI Cai-zhou, et al. 203true ［Abstract］　Objective　To study the significances of serum cholesterol and liver function indexes in diagnosis of different types of gallstone.Methods　The clinical data of 158 inpatients with gallstones in our hospital were divided into the cholesterol gallstone group and the non-cholesterol gallstone group according to the different amounts of cholesterol in the gallstones after operation. The levels of serum total cholesterol(TC) and liver function indexes(ALT, AST, ALP, TP, G, ALB, TB, DB and IB) were analyzed in the two groups to screen out the specific indexes. ROC curve was applied to analyze the specificity and sensitivity of different types of gallstone. The diagnostic threshold value was calculated by Youden index.Results　The levels of TC and AST in the cholesterol gallstone group were higher than those in the non-cholesterol gallstone group. The level of DB in the cholesterol gallstone group was lower than that in the non-cholesterol gallstone group(P<0.05). The threshold values of TC, AST and DB on diagnosing cholesterol gallstone and non-cholesterol gallstone were 5.27, 52.25 and 4.51, respectively.Conclusion　TC, AST and DB have significant diagnostic value for preliminarily separating cholesterol gallstone from non-cholesterol gallstone before operation.]]> 2017/11/28 17:12:43 LIU Lei, HAN Wen-hao, CHEN Tao, et al. 202true ［Abstract］　Objective　To detect the serum levels of osteoprotegerin(OPG) in the patients with essential hypertension(EH) and in the healthy people, and to explore its clinical significances.Methods　The serum levels of OPG in 128 patients in our hospital from May 2013 to December 2014 were measured using enzyme-linked immunoadsorbent -assay(ELISA). The patients were divided into the control group(n=40), grade 1 EH group(n=27), grade 2 EH group(n=30) and grade 3 EH group(n=31). The levels of TC, TG, LDL-C, HDL-C and CRP were detected.Results　Compared with the control group, the EH group had significantly higher levels of serum OPG(P<0.05). With the increase of blood pressure, serum levels of OPG were significantly higher(P<0.05). The serum levels of OPG were positively related to SBP and DBP in the patients with EH(P<0.01).Conclusion　The serum levels of OPG are significantly increased, and are positively correlated with SBP and DBP in the patients with EH, indicating that it might be used as a laboratory indicator for the diagnosis and evaluation of EH.]]> 2017/11/28 17:12:43 SU Rong, LIU Yun-lan, TANG Shu-rong, et al. 201true ［Abstract］　Objective　To explore the clinical effects of two different laparoscopic operative types on treating cornual pregnancy.Methods　A retrospective analysis of clinic data of 46 patients with cornual pregnancy who underwent operations by two different laparoscopic operative types was performed. The patients were collected from the People′s Hospital of Guangxi Zhuang Autonomous Region during January 2010 and June 2014, and were divided into the cornual pregnancy site wedge resection group(resection group, n=19) and the cornual pregnancy site dissection and removing embryo group(dissection group, n=27). The preoperative conditions, the surgical parameters were compared between the two groups during and after the operation.Results　There were no significant differences in the surgical parameters during and after the operation between the two groups(P>0.05), but the operation time and the amount of bleeding during the operation in the resection group were significantly shorter or less than those in the dissection group(P<0.05). Salpingography showed that tubal patency improved better in the dissection group than in the resection group(P<0.05). There were no significant differences in the contralateral tube and pelvic adhesion postoperatively between the two groups(P>0.05).Conclusion　Both of laparoscopic cornual pregnancy site wedge resection and cornual pregnancy site dissection and removing embryo are effective for treating cornual pregnancy, and the former operative type may increase the obstructive risk of ipsilateral tube.]]> 2017/11/28 17:12:43 HUANG Wei-rong, ZHAO Ren-feng, WU Yu-ying, et al. 200true ［Abstract］　Objective　To establish a method of quantitative determination of formononetin in Fukeqianjin capsules.Methods　Formononetin was extracted by 70% methanol solution and the content of formononetin in Fukeqianjin capsules was determined by high-performance liquid chromatography(HPLC). N2000 chromatographic work station was used with the mobile phase of acetonitrile-water(45∶55) and the UV detecting wavelength being at 254 nm.Results　Within the scope of the concentration of formononetin from 3.042 to 7.098 μg·ml^-1, the amount of samples and its peak areas had a good linear relationship(r=0.999 9), with a recovery rate of 98.4% and a relative standard deviation(RSD) of 3.03%(n=5).Conclusion　The method is accurate, simple and fast, and suitable for the quality control of Fukeqianjin capsules.]]> 2017/11/28 17:12:43 ZHOU Shu-guang, PAN Hong-ping 199true ［Abstract］　Objective　To study the clinical value of application of pressurized lacrimal irrigation and probing of lacrimal passages in the treatment of neonatal dacryocystitis.Methods　50 children with neonatal dacryocystitis(64 eyes) were selected as the research subjects from February 2015 to April 2016 and were randomly divided into group A(n=25, 31 eyes) and group B(n=25, 33 eyes). The patients in group A were treated with probing of lacrimal passages therapy while those in group B were treated with pressurized lacrimal irrigation. The curative effect, complications and satisfaction rate of children′s parents were compared between the two groups.Results　The cure rate of group A(93.55%) was significantly higher than that of group B(P<0.05). The incidence of complications in group A(4%) was significantly lower than that in group B(P<0.05). The satisfaction rate in group A(96%) was significantly higher than that in group B(72%)(P<0.05).Conclusion　The clinical effect of probing of lacrimal passages is better than that of pressurized lacrimal irrigation in the treatment of neonatal dacryocystitis.]]> 2017/10/26 8:15:41 LIN Hai-bo, LI Wen-lin, ZHUO Xiao 198true ［Abstract］　Objective　To explore the effect of oral administration of nicorandil on coronary microcirculation resistance index(IMR) in patients with stable angina pectoris.Methods　56 patients with stable angina pectoris treated from March 2014 to March 2016 were selected and randomly divided into the treatment group and the control group, with 28 cases in each group. The control group took isosorbide dinitrate, and the treatment group was treated with nicorandil treatment for 4 weeks. The clinical effect of IMR was compared between the two groups before and after treatment.Results　After treatment, IMR of the treatment group (16.87±4.71) was lower than that of the control group (26.21±8.61), with a significant difference between the two groups(P<0.05). In the treatment group, 14 cases were markedly effective, 12 cases effective, and 2 cases ineffective. In the control group, 9 cases were markedly effective, 11 cases effective, and 8 cases ineffective. The curative effect of the treatment group was better than that of the control group(P<0.05).Conclusion　Nicorandil can effectively reduce IMR and improve the coronary microcirculation and cardiac function on the basis of routine treatment for the patients with stable angina pectoris.]]> 2017/10/26 8:15:41 HAN Wen-jie, LIU Heng-liang 197true ［Abstract］　Objective　To improve the diagnosis and treatment of pulmonary alveolar microlithiasis(PAM).Methods　The clinical manifestations and radiological and pathological characteristics of PAM in two patients were analyzed and the related literatures were reviewed.Results　One of the two patients presenting with progressive shortness of breath on exertion for two months was admitted to our hospital with clinical presentation of pulmonary heart disease. A chest computed tomography(CT) scan showed typical features with multiple bilateral diffuse calcifications. The other patient showed no obvious symptoms, but transbronchial lung biopsy(TBLB) showed numerous calcified bodies in the alveolar spaces and CT scan showed multiple bilateral diffuse calcifications. Based on the aforementioned observations, the two patients were diagnosed with PAM.Conclusion　The clinical presentation of PAM is non-specific. The typical radiological features and the pathological characteristics are helpful for diagnosis of PAM.]]> 2017/10/26 8:15:41 LUO Ling, ZHAO Yuan, WEI Cai-zhou, et al. 196true ［Abstract］　Objective　To explore the clinical effect of montelukast sodium combined with seretide on bronchial asthma.Methods　72 patients with bronchial asthma were selected in our hospital from January 2015 to June 2016 and were randomly divided into two groups, with 36 cases in each group. The control group received seretide(50 μg, bid), and the treatment group received montelukast sodium(10 mg, qd) combined with seretide(50 μg, bid) for 12 weeks. The clinical efficacy was compared between the two groups.Results　In the treatment group, 23 cases were markedly effective, 11 cases effective, and 2 cases invalid. In the control group, 14 cases were markedly effective, 13 cases effective, 9 cases invalid. The curative effect of the treatment group was significantly better than that of the control group(P<0.05). Before the treatment, there were no significant differences in forced expiratory volume in one second(FEV₁), peak expiratory flow(PEF) and forced vital capacity(FVC) between the two groups(P>0.05); After the treatment, the pulmonary function was significantly higher than that before the treatment in both of the two groups, and the pulmonary function of the treatment group was significantly higher than that of the control group after the treatment(P<0.05).Conclusion　Montelukast sodium combined with seretide can significantly improve the lung function and clinical symptoms in the patients with bronchial asthma.]]> 2017/10/26 8:15:41 HOU Hui-na 195true ［Abstract］　Objective　To evaluate the effect of EB virus(EBV) on diffuse large B-cell lymphoma(DLBCL) treated with R-CHOP chemotherapy. Methods　The domestic and abroad authoritative databases were retrieved to find the published literature of R-CHOP chemotherapy for EBV positive DLBCL in PUBMED (1994-04 ～ 2017-04), CNKI (1994-04～2017-04), Cochrane library(1994-04～2017-04) and WanFang Data(1996-12～2017-04). The quality of the included studies was assessed by the Cochrane system method and Meta-analysis was performed using RevMan 5.0 software. Results　Seven randomized controlled trials involving 140 EBV-positive patients and 1812 EBV-negative patients were included. Meta-analysis indicated that EBV-positive group was worse than EBV-negative group in overall survival(HR=3.24, 95%CI=1.88～5.58, P<0.0001) and progression-survival(HR=1.83, 95%CI=1.44～3.25, P=0.0002). Conclusion　In the era of R-CHOP chemotherapy for DLBCL, EBV-positive is still the main adverse prognostic factor. The efficacy of R-CHOP chemotherapy for DLBCL is still uncertain, and EBV may involve in the occurrence and development of DLBCL.]]> 2018/9/30 16:15:18 WEI Hua-ping 194true ［Abstract］　Objective　To evaluate the etiology of acute respiratory infections in children in Lanzhou area, and to analyze the epidemiological characteristics of acute respiratory infections for prevention and treatment. Methods　IgM antibodies of RSV, PIV, ECHOV, CoxV, ADV, EBV and MP in blood samples were detected in 541 of 590 hospitalized children during their acute period in the First Affiliated Hospital of Lanzhou University, among whom 475 cases underwent bacterial culture. Results　The positive rates of IgM antibodies were as following: RSV(23.84%), ADV(18.30%), ECHOV(17.74%), CoxV(11.46%), EBV(9.98%), PIV(3.33%) and MP(12.94%). The positive rate for sputum/ pharyngeal swab bacterial culture was 19.79%. The top three were streptococcus pneumoniae, klebsiella pneumoniae, and staphylococcus aureus. Conclusion　The main pathogens leading to acute respiratory infections in Lanzhou area are RSV, ADV, MP, and streptococcus pneumoniae and klebsiella pneumoniae. The younger the children are, the more likely they are to be infected with bacteria. Viral infections are more common in infants and preschool children.]]> 2018/9/30 16:15:19 XU Hui, SHANG Yun-jie, CHENG Xue-rong, et al. 193true ［Abstract］　Objective　To study the curative effect of laparoscopic thyroidectomy on benign thyroid lesions via breast areola approach. Methods　52 patients with benign thyroid lesions were selected in our hospital from March 2014 to March 2016 and were randomly divided into two groups. The observation group(n=26) was given laparoscopic thyroidectomy via breast areola approach for benign thyroid lesions, and the control group(n=26) received open thyroidectomy. The operative time, intraoperative blood loss, volume of drainage, length of hospitalization and operative complications were compared between the two groups. Results　There was no significant difference in the effective rate between the two groups（P>0.05）. Compared with those in the control group, the time of operation, the amount of blood loss, the volume of drainage and the length of hospitalization in the observation group were significantly reduced(P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group(P<0.05). Conclusion　Laparoscopic thyroidectomy can obviously reduce the incidence of surgical complications, shorten the hospital stay and relieve the pain for the patients with benign thyroid lesions.]]> 2018/9/30 16:15:19 YU Chun-liang, HUO Hong-jun, ZHOU Bai-gang 192true ［Abstract］　Objective　To explore the application value of hydrothorax biochemical indexes combined with tumor markers in differentially diagnosing malignant pleural effusion of lung cancer. Methods　70 cases of lung cancer were selected as the research objects(the lung cancer group) in our hospital from January 2016 to December 2017, and 70 patients with other respiratory diseases(pneumonia, chronic obstructive pulmonary disease) and pleural effusion were selected as the control group during the same period. The 5 items of hydrothorax biochemistry, pleural effusion and serum tumor marker levels were compared between the two groups. Results　The levels of TP, FET, LDH, pleuval LDH/serum LDH ratio, CEA, CA19-9, CA153, CA125 and CYFRA21-1 in pleural effusion of the lung cancer group were significantly higher than those of the control group(P<0.01). The serum levels of CA19-9, CA153, CA125, and CYFRA21-1 in the lung cancer group were significantly higher than those in the control group(P<0.01). In the tumor markers of the lung cancer group, the areas under ROC curve were greater than 0.8 with CEA, CA153, and CYFRA21-1 in the pleural effusion, while the ROC curve with an area greater than 0.8 was only CYFRA21-1 in the serum. Conclusion　The biochemical indicators of TP, FET, LDH and pleural LDH/serum LDH ratio in pleural effusion and the serum tumor markers can be used as differential diagnosis indexes for malignant pleural effusion of lung cancer, and CYFRA21-1 has the highest clinical value in distinguishing malignant pleural effusion from lung cancer.]]> 2018/9/30 16:15:19 ZOU Guang-mei, HUANG Chao-ren, WU Bo-wen, et al. 191true ［Abstract］　Objective　To study the features of ultraviolet-visible(UV-Vis) spectroscopy in extracting solutions of Zeamays L bracts in polar solvents with different gradients,and to provide a basis for quality control of the bracts. Methods　The extracting solutions of Zeamays L bracts were made by ultrasound, cold soak and solvent refluxing methods respectively with different gradients of polar solvents［distilled water, 95% ethyl alcohol, ethyl acetate, n-butyl alcohol and petroleum ether(boiling range 60～90 ℃)］, and their absorbance values were measured by scanning using UV-Vis spectroscopy to establish the characteristic absorption spectra, with the range of detection wavelength being 200～800 nm and the absorbance values being 0.2～0.8. Results　The extracting solutions of Zeamays L bracts displayed certain spectral features in UV-Vis spectroscopy. Conclusion　The UV-Vis spectrum method established in this experiment has a reference meaning and great value for identification of Zeamays L bracts.]]> 2018/9/30 16:15:19 ZHOU Shu-guang, ZHEN Han-shen, ZHEN Dan-dan, et al. 190true ［Abstract］　Objective　To investigate the clinical effect of a new seven-hole decompression method on treatment of early osteonecrosis of the femeral head in adults. Methods　A prospective case-control study was performed. 55 patients with early osteonecrosis of the femoral head were treated in our hospital from May 2015 to October 2016, including 26 patients(30 hips) with stage I(ARCO standard) and 29 patients(35 hips) with stage Ⅱ. The new seven-hole decompression was performed on 20 hips(the new type group) and traditional three-hole decompression therapy on 25 hips(the traditional group) and conservative medication on 20 hips(the conservative group). All the patients were followed up for 1 year to evaluate the clinical efficacy and the clinical effects were compared among the three groups. Results　All the patients in the three groups completed the treatments and obtained effective treatments. At the last follow-up after treatment, Harris scores were significantly improved in all the three groups compared with those before treatment(P<0.001). Harris scores in the new type group were improved better than those in the traditional group and the conservative group(P<0. 001). The incidence of the femoral head collapse in the new type group was lower than that in the traditional group or in the conservative group(P<0.05). Conclusion　The new seven-hole decompression method has obvious advantages in the treatment of early femoral head necrosis in adults. It can improve the hip function and delay the collapse of the femoral head necrosis.]]> 2018/9/30 16:15:19 SHAN Xiao-wei, ZHANG Chen-lu, MA Hang, et al. 189true ［Abstract］　Objective　To explore the application of noninvasive ventilation(non-IV) for weaning from invasive ventilation(IV) in patients with bronchiectasis and acute respiratory failure(ARF) for early extubation at the time of pulmonary infection control(PIC) window. Methods　90 bronchiectasis patients were collected from 2 general hospitals in Longyan city, southeast China during January 2014 and December 2016, who all received IV in ICU/RICU because of AFR due to severe pulmonary infection. The patients were randomly divided into two groups(control group and treatment group). When the PIC window appeared, control group(n=45) continued to use the SIMV+PSV mode for weaning. Treatment group(n=45) was supposed to extubate immediately at the PIC window, and accepted non-IV treatment continuously. 5 of the 45 patients in treatment group withdrew the study halfway. Indices(including the length of IV, ICU stay and total hospital stay, the average costs of hospitalization, the occurrence of VAP, the in-hospital mortality, the success rate of weaning from IV for the first time and the rate of re-ventilation) were observed and compared between the two groups. Results　85 patients were enrolled finally. No significant differences in the demographic, respiratory, hemodynamic characteristic and PIC window occurrence were indicated between the two groups. The incidence of VAP was 22.22%(10/45) in control group and 5.00%(2/40) in treatment group(P=0.02). The in-hospital mortality was 11.11%(5/45) in control group and 0%(0/40) in treatment group(P=0.04). The duration of IV was (6.89±1.82) d in control group and (4.85±3.23)d in treatment group(P=0.01). The RICU/ICU stay was (9.44±2.98)d in control group and (6.38±2.58)d in treatment group(P=0.00). The total hospital stay was (15.78±6.32)d in control group and (17.00±8.59)d in treatment group(P=0.45). The success rate of weaning from IV for the first time was 88.89%(40/45) in control group and 95.00%(38/40) in treatment group(P=0.44). The rate of re-ventilation was 13.33%(6/45) in control group and 5.00%(2/40) in treatment group(P=0.27). The average costs of hospitalization were (39273.55±17086.92)YAN(RMB) in control group and (37095.31±15306.62)Yan(RMB) in treatment group(P=0.54). Conclusion　The application of non-IV in the patients with bronchiectasis and ARF at the time of PIC window can significantly decrease the duration of IV, the ICU/RICU stay, the occurrence of VAP and the in-hospital mortality. It is an effective and feasible method for clinicians to try early extubation in the patients with bronchiectasis and ARF.]]> 2018/8/24 16:25:15 ZOU Xin, MA Zhi-yi, LIN Jin-hao, et al. 188true ［Abstract］　Objective　To compare the curative effects of posterior pedicle different intermediate screws internal fixation and spinal fixation on thoracolumbar fractures. Methods　The data of 48 thoracolumbar fracture patients were retrospectively analyzed. There were divided into three groups according to different operation methods: Shortsegment pedicle instrumentation group（group A, n=17）, intermediate screws group(group B, n=20）, monosegment pedicle instrumentation group(group C, n=11）. The operative time and intraoperative blood loss, follow-up wounded vertebral Cobb Angle correction and the postoperative complications were compared among the three groups. Results　Among the three groups, the operative time and blood loss in group C were the least(P<0.05). After the last follow-up visit, the correction of the fracture vertebra cobb angles in group B was significantly better than that in group A or group C（P<0.05）, but there was no significant difference between group A and group C(P>0.05). Conclusion　The three operative methods can all effectively fix the vertebral body and restore the stability of the spine. Intermediate screws are better than the other two kinds of operation methods in stabilizing vertebral height loss and cobb angles. The effect of monosegment pedicle instrumentation is equal to that of shortsegment pedicle instrumentation, but has advantages of less trauma, shorter operation time and less blood loss.]]> 2018/8/24 16:25:15 LIN Zhen-hua, HUANG Shuai, HE Jia-nan, et al. 187true ［Abstract］　Objective　To analyze the causes that affect the achievement of blood pressure target rate in septic shock patients, and to develop countermeasures to improve the target rate and clinical prognosis. Methods　Improving the target rate of blood pressure was done by using the quality control circle tool, including four steps of holding current situation, goal setting, resolution and countermeasures. Results　The blood pressure target rate in the patients with septic shock was increased from 61.1% to 83.0 % after the quality control circle was implemented. Conclusion　Quality control circle can be used to find out the causes that septic shock pressure control fails to achieve standard. The method effectively raises the target rate of blood pressure and improve the patients′ prognosis.]]> 2018/8/24 16:25:15 LI Deng-kai, ZHANG Xing-hua, AN Jian-xiong, et al. 186true ［Abstract］　Objective　To investigate the prevalence of chronic non-communicable diseases and their influencing factors among elderly permanent residents in Chengyang district of Qingdao city, and to provide theoretical basis for the intervention treatment of chronic diseases in the elderly. Methods　Multi-stratified clustering sampling method was used to conduct a questionnaire survey of 9 198 residents(more than 65 years old) of 8 subdistricts in Chengyang district of Qingdao city. Results　The epidemiological investigation revealed that the 65～69 year old group had the highest participation rate(42.81%). The prevalence rates of chronic diseases and non-communicable diseases were ranked as follows: hypertension(HT)(71.16%), overweight/obesity(OW/OB)(68.62%), dyslipidemia(DLP)(65.18%) and hyperglycemia (HG) (63.66%). The results of multivariate Logistic regression analysis showed that the risk factors of chronic non-communicable diseases were positively related to age(OR=4.547, 95%CI=3.162～7.834), smoking status(OR=3.252, 95%CI=2.125～4.608), high fat and low plant foods(OR=3.870, 95%CI=3.440～4.202), psychological status(OR=2.426, 95%CI=2.030～2.880) and spouses loss(OR=1.148, 95%CI=1.041～1.504), and were negatively related to college education(OR=0.513, 95%CI=0.419～0.780), self-care awareness(OR=0.452, 95%CI=0.310～0.762), family income(OR=0.956, 95%CI=0.936～0.989), and physical activity levels(OR=0.845, 95%CI=0.796～0.995). Conclusion　HT, OW/OB, DLP and HG are the common chronic diseases in the elderly residents in Chengyang district of Qingdao city. The risk factors are age, smoking, high fat and low plant foods, mental state and spouses loss. The protective factors are college education, self-care awareness, family income and physical activity.]]> 2018/8/24 16:25:15 RAO Xiao-pang, SHI Xiu-juan, XU Mei-hua, et al. 185true ［Abstract］　Objective　To discuss the value of different methods in diagnosis of bone marrow infiltration(BMI) in the patients with non-Hodgkin′s lymphoma(NHL), and to analyze the correlation between BMI and other clinical features and mid-term efficacy, and to analyze the influence on prognosis of NHL. Methods　The clinical data of 74 patients who were pathologically diagnosed with NHL and were treated in our hospital were collected. After follow-up survey, several common diagnostic test evaluation indicators were used to evaluate different examination methods to assess the diagnostic value of BMI. Correlation analysis was made to determine the correlation between BMI and other clinical features of NHL. Chi-square test was used to analyze the relationship between BMI and mid-term efficacy. The survival analysis of K-M method was used to determine the effect of BMI on the prognosis. Results　22 of the 74 cases had bone marrow infiltration, including 18 cases of bone marrow cytology, 12 cases of bone marrow pathology(A total of 66 cases were examined), 12 cases of PET/CT detection(A total of 68 cases were examined). BMI was weakly associated with B symptom, stages and IPI scores(P=0.012, 0.007, r=0.290, 0.311), and moderately associated with the clinical stages(P=0.000, r=0.731). BMI was related to the mid-term efficacy(χ²=5.305, P=0.006). 2-year progression free survival and total survival rates in the patients with BMI were lower than those in the patients without infiltration, K-M survival analysis found no significant effect(Log Rank P=0.098, 0.129). Conclusion　Bone marrow cytology, bone marrow pathology and PET/CT are of great value to diagnose BMI in the patients with NHL. The combined diagnostic value of the three methods is the most valuable to increase the detection rate of BMI in NHL patients.]]> 2018/7/30 16:15:14 ZHANG Yan-ru, WANG Ze-you, TANG Ling-li 184true ［Abstract］　Objective　To evaluate the effect of dexmedetomidine on postoperative lung function and stress response in patients undergoing laparoscopic radical gastrectomy. Methods　Eighty patients undergoing laparoscopic radical gastrectomy for gastric cancer in our hospital from June 2015 to November 2017 were randomly divided into control group(group C) and dexmedetomidine group(Dex group), with 40 cases in each group. Both of the two groups received general anesthesia combined with epidural anesthesia. Before general anesthesia induction but after epidural catheterization, Dex group was given an intravenous infusion of dexmedetomidine 0.3 μg/kg for 10 min and an intravenous infusion rate of 0.4 μg/(kg·h) after tracheal intubation until 30 minutes before the end of surgery, and C group was given equal volume of saline. Peripheral venous blood was collected before dexmedetomidine infusion(T₀), immediately before ventilation(T₁) and at 1, 6, and 24 hours after the epidural catheter(T₂ to T₄). Interleukin 6(IL-6), interleukin 10(IL-10), tumor necrosis factor-α(TNF-α), and malondialdehyde(MDA) concentration were detected. At the same time, arterial blood gas analysis was performed to calculate the respiratory index(RI) and oxygenation index(OI), and the occurrence of OI≤300 mmHg was recorded. Results　Compared with those in C group, the levels of serum IL-6 and TNF-α and RI were decreased, but IL-10 concentration and OI were increased in Dex group at T₁～T₄(P<0.05). Compared with those in C group, the MDA concentration was decreased and the incidence of OI≤300 mmHg was decreased in Dex group at T₁～T₃(P<0.05). Conclusion　Dexmedetomidine can inhibit inflammation in the patients undergoing laparoscopic surgery and improve their postoperative pulmonary function.]]> 2018/7/30 16:15:14 WANG Jun-liang, HAN Mei 183true ［Abstract］　Objective　To investigate the correlation between relative expression of MicroRNA-181b and the severity of coronary artery lesions in peripheral blood mononuclear cells(PBMCs) of the patients with coronary artery disease(CHD), and to study the significance of modification of MicroRNA-181b in patients with coronary artery disease. Methods　A total of 117 patients with chest pain who received coronary angiography in department of cardiology of our hospital were selected, including 42 cases in the control group and 75 cases in the coronary heart disease(CHD) group. According to the symptoms, ECG, CK-MB, troponin and the findings in coronary angiography, the CHD group was divided into three different subgroups: stable angina subgroup(n=30, SAP subgroup), unstable angina subgroup(n=22, UAP subgroup) and acute myocard infarction subgroup(n=22, AMI subgroup). In each group, the general clinical data, blood biochemical markers, as well as Gensini scores were recorded. The relative expression of MicroRNA-181b was detected by real-time fluorescent quantitative PCR. To explore the possibility of application of microRNA-181b in coronary artery diseas. Results　In the CHD group, Gensini scores were negatively correlated with the relative expression level of MicroRNA-181b. The relative expression levels of MicroRNA-181b in the CHD group were significantly lower than those in the control group(P<0.05). Conclusion　In coronary heart disease group, the relative expression of microRNA-181b decreased, the lower relative expression of microRNA-181b the heavier severity of coronary artery lesions. The relative expression levels of microRNA-181b was negatively correlated with the severity of coronary artery stenosis.Higher relative expression of microRNA-181b is likely to be a inhibitory factor in the development of coronary heart disease.]]> 2018/7/30 16:15:14 LIANG Kai-qin, WANG Hong, CHENG Wen-gong 182true ［Abstract］　Objective　To explore the clinical efficacy of enhanced recovery after surgery(ERAS) combined with laparoscopic surgery for colorectal cancer. Methods　From January 2016 to March 2017, 120 patients with colorectal cancer undergoing laparoscopic surgery in our hospital were selected as the study subjects. The patients were divided into two groups according to a random number table, with 60 cases in each group. The control group was performed the routine perioperative treatment, and the observation group underwent perioperative intervention guided by the concept of ERAS. The recovery results, immune function and scores of life quality were compared between the two groups. Results　The recovery time of intestinal function and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.01). The immune function indexes of the two groups were significantly decreased 3 days after operation(P<0.05), but the immune function indexes of the observation group was higher than those of the control group 3 days after operation(P<0.05). The immune function of the observation group returned to the preoperative level 7 days after operation, but the immune function of the control group was still lower than that before operation(P<0.05). The scores of life quality in the observation group were significantly higher than those in the control group(P<0.01). Conclusion　Patients undergoing laparoscopic surgery for colorectal cancer should be treated with perioperative interventions based on the concept of ERAS, which can effectively improve the postoperative recovery rate, reduce the impact of surgery on the patients′ immune function, protect the immune function, and improve the life quality of the patients.]]> 2018/6/29 17:08:36 DU Guang-sheng, QIU Yuan, PENG Ke, et al. 181true ［Abstract］　Objective　To evaluate the clinical efficacy of ascites ultrafiltration and peritoneal reinfusion combined with regular infusion of albumin in treatment of refractory ascites. Methods　40 patients with refractory ascites were divided into ascites ultrafiltration group and peritoneal reinfusion group. Both of the two groups were given albumin infusion. The changes of body weight, abdominal circumference, 24 h urine output and short-term and long-term ascites control rates were compared between the two groups, and the nutritional status of the patients and the 1, 2, 3-year overall survival rates were observed. Results　The body weight［（66.9±3.3）kg vs （69.6±3.0）kg, P<0.05］ and abdominal circumference［（92.9±6.9）cm vs （101.0±5.5）cm, P<0.01］ were significantly decreased after 7 days of treatment, and the urine output［（1523.6±178.2）ml vs （880.5±124.1）ml, P<0.01］ were significantly increased in the peritoneal reinfusion group, but there were no significant differences before and after the treatment in the ascites ultrafltration group(P>0.05). The short-term ascites control rates were 90% and 10% in the peritoneal reinfusion group and the ascites ultrafltration group, respectively, the long-term ascites control rates were 90% and 0% in them, respectively, with a significant difference between the two groups(P<0.01). The 1, 2, and 3 year survival rates were 100%, 95%, and 80% in the peritoneal reinfusion group, respectively. Conclusion　Ascites ultrafiltration and peritoneal reinfusion combined with regular infusion of albumin is safe and effective in treatment of refractory ascites.]]> 2018/6/29 17:08:36 WANG Xin-ting, ZHANG Chuan-lei, CHEN Xiao-qi, et al. 180true ［Abstract］　Objective　To observe the efficacy and toxicity of paclitaxel combined with lobaplatin intraperitoneal chemotherapy in treatment of recurrent ovarian cancer. Methods　28 patients with recurrent ovarian cancer were treated with paclitaxel combined with intraperitoneal perfusion chemotherapy with lobaplatin, paclitaxel 135 mg/m² ivgtt d1+ lobaplatin 50 mg/m² ip d2, every 3 weeks for a cycle. The curative effect and adverse reactions were observed after the completion of 4 cycles. Results　Paclitaxel plus lobaplatin intraperitoneal chemotherapy had better effectiveness for treatment of recurrent ovarian cancer. The lesion control rate, the ascites control rate and the CA125 reduction rate were 82.1%, 87.5% and 85.7% respectively.The main adverse reactions were bone marrow suppression, gastrointestinal reactions and neurotoxicity. The patients were tolerable after symptomatic treatment. Conclusion　Paclitaxel combined with lobaplatin intraperitoneal chemotherapy is safe and effective in treatment of recurrent ovarian cancer.]]> 2018/6/29 17:08:36 QU Yuan-yuan 179true ［Abstract］　Objective　To summarize the practice of clinical pharmacists participating in anti-infective treatment of intracranial infection after operation. Methods　The clinical pharmacists participated in all aspects of the anti-infective treatment of intracranial infection after neurosurgery operation in 1 case with cerebral tumor. The clinical pharmacists observed the patient′s condition carefully, discussed the therapeutic schemes with doctors, monitored the blood concentrations, evaluated the curative effects and closely observed the adverse reactions. Results　The patient was followed up for 6 months and his infection was eradicated and he had a good recovery after individualised drug administration was given and the blood trough concentration of Vancomycin was monitored. The pharmacists and doctors acquired the relevant experience of anti-infective treatment of intracranial infection after operation. Conclusion　The pharmacists can not only provide pharmaceutical care, but also improve the service of the medical team by participating in all aspects of the medication and offering the individualised drug administration.]]> 2018/6/29 17:08:36 LU Mei, ZHENG Xin, GAN Quan 178true ［Abstract］　Objective　To compare the analgesic effects of transversus abdominis plane(TAP) block and local anaesthetic wound infiltration on general anesthesia in adult abdominal surgery. Methods　We searched Chinese and English databases for randomized controlled trials(RCTs) comparing TAP block with wound infiltration for pain relief after abdominal surgery by computer. RevMan 5.3 software was used for data analysis. Results　8 RCTs with a total of 447 participants were included. (1)There was no significant difference between TAP block and local anaesthetic wound infiltration for postoperative rest pain scores 1 hour after operation［WMD=-0.33, 95%CI=(-0.78,0.12), P=0.15］, but TAP block was associated with apparent lower movement pain scores 1 hour after operation than wound infiltration［WMD=-1.09, 95%CI=(-1.85,-0.32), P=0.006］. (2)TAP block was associated with lower rest pain scores and movement pain scores 6 hours after operation than wound infiltration［WMD=-0.69, 95%CI=(-1.04, -0.35), P<0.0001］, ［WMD=-0.71, 95%CI=(-1.32, -0.10), P=0.02］. (3)TAP block was associated with significant lower rest pain scores 12 hours after operation than wound infiltration［WMD=-0.56, 95%CI=(-1.02, -0.09), P=0.02］. (4)TAP block was associated with significant lower rest pain scores 24 hours after operation than wound infiltration［WMD=-0.35, 95%CI=(-0.65, -0.05), P=0.02］, however, there was no significant difference between TAP block and local anaesthetic wound infiltration for postoperative movement pain scores 24 hours after operation［WMD=-0.47, 95%CI=(-1.17, 0.24), P=0.19］. Conclusion　TAP block has a better anaesthetic effect than wound infiltration in the intermediate-term of postoperation statistically, but there is no significant difference in the anaesthetic effect between the two anesthetic methods clinically.]]> 2018/6/29 17:08:36 GAO Xu-ping, YANG Bao-zhong 177true ［Abstract］　Objective　To study the clinical effect of ulnar nerve minimally invasive in situ release on treatment of cubital tunnel syndrome. Methods　Nine patients with cubital tunnel syndrome were treated with ulnar nerve minimally invasive in situ release. The patients included 7 males and 2 females, aged from 22 to 64 years［average (38.4±5.2)years］. The duration of the disease ranged from 4 to 21 months［average (8.4±1.7)months］. Among the patients, McGowan Ⅰ was in 2 cases,Ⅱ in 5 cases and Ⅲ in 2 cases. The clinical effect was observed. Results　The nine patients were followed up for 15 months averagely, and the results were graded according to the Messina index. Of the nine patients, 5 were excellent, 2 were good and 2 were fair. Conclusion　Minimally invasive in situ release of ulnar nerve is effective in treatment of cubital tunnel syndrome, with advantages of minimal invasion, shorter operative time and less complications.]]> 2018/6/29 17:08:36 GUO Chun-yun, HUANG Feng, LIANG Zhen, et al. 176true ［Abstract］　Objective　To study the clinical effects of rehabilitation therapy and the prognosis on patients with ischemic stroke in different periods.Methods　87 patients were randomly divided into two-day rehabilitation training group and fourteen-day rehabilitation training group. The patients were trained as requested and their data were collected and analyzed at the beginning and 3 months after onset.Results　There were no significant differences in the scores of NIHSS, Fugl-Meyer motor function, Barthel index and Hamilton Depression scale between the two groups(P>0.05). After 3 months of treatment, the above scores were (9.72±5.37), (65.21±13.27), (76.87±12.68), and (29.06±11.48) in the two-day rehabilitation training group, and (12.14±2.76), (52.67±14.28), (62.85±11.69), and (34.23±5.43) in the fourteen-day rehabilitation training group. The clinical effect of the two-day rehabilitation training group was better than that of the fourteen-day rehabilitation training group（P<0.05）. Conclusion　Earlier rehabilitation therapy improves the limb motor function and self-care ability for daily life, and reduces the symptoms of depression in the patients with ischemic stroke.]]> 2018/5/30 8:21:22 LI Yong-ping, GAO Yang 175true ［Abstract］　Objective　To evaluate the diagnostic value of dual source CT for urate crystal deposition in gout patients in Beibu Gulf area.Methods　Bilateral knee joints, ankle joints and bipedal dual energy CT scans were performed in 28 patients who were diagnosed with gout（the gout group）. The control group consisted of 10 non-gout patients who were performed the same CT scans. The data were analyzed using gout software to record the presence of urate crystals and their distribution. The differences of urate deposition were compared between the two groups.The difference between the location of urate crystal deposition and the clinical evaluation was detected by dual source CT.Results　Urate crystals were found in 124 cases in the gout group by dual energy CT scan, which was 2.43 times higher than the lesions of the the clinical assessment(51 lesions). The most common site of the lesions was the first metatarsophalangeal joints(37.9%), followed by the ankles(25.8%) and the last was the knees(15.3%). 13 patients suffered from bone destruction in varying degrees, 16 cases were multiple joint destruction, and all the patients were accompanied by soft tissue swelling. No urate crystals were found in the control group.Conclusion　Dual source CT scans can show urate crystal deposition qualitatively and quantitatively, which is of great clinical significance for early non-invasive diagnosis, prevention and treatment of gout patients in the Beibu Gulf region.]]> 2018/5/30 8:21:22 CHEN Song, HUANG Ze-he, CHEN Guang, et al. 174true ［Abstract］　Objective　To investigate the clinical efficacy of aerobic exercise combined with ursodeoxycholic acid in treatment of non-alcoholic fatty liver disease(NAFLD).Methods　135 patients with NAFLD in our hospital from April 2014 to June 2017 were randomly divided into 3 groups: aerobic exercise group, ursodeoxycholic acid group and aerobic exercise combined with ursodeoxycholic acid group(combined group), with 45 cases in each group. The three groups received the same basic treatment in the outpatient clinic,besides the aerobic exercise group and the ursodeoxycholic acid group were treated with aerobic exercise plus ursodeoxycholic acid capules 250 mg for 3 months, the combined group received ursodeoxycholic acid capules plus aerobic exercise therapy for 3 months. Other 45 healthy subjects were selected as the control group. The changes of body shape(WHR, BMI) were compared among the three groups before and after intervention. The changes of liver function, blood lipid and fatty liver degree were compared among the patients with NAFLD in the three groups before and after intervention.Results　After intervention, the WHR indexes in the patients with NAFLD in the three groups were significantly decreased compared with those before intervention(P<0.05).There were no significant differences in the BMI indexes among the three groups before and after intervention(P>0.05). The clinical total effective rates were 44.44%, 53.33% and 77.78% in the three group respectively(P<0.01). The levels of ALT, AST and gamma-GT in the NAFLD patients of the three groups were significantly decreased compared with those before intervention（P<0.05）, while HDL-C was increased than that before treatment(P<0.05). The fatty liver recovery rates were 8.89%, 22.22% and 33.33% in the NAFLD patients of the three groups(P<0.05).Conclusion　The clinical curative effect of aerobic exercise combined with ursodeoxycholic acid is more superior to that of aerobic exercise or using ursodeoxycholic acid alone in treatment of NAFLD. It can effectively improve liver function, reduce blood lipids and improve the patients′ quality of life.]]> 2018/5/30 8:21:22 DUAN Xue-hui, WU Wei-dong, TAN Yan-meng 173true ［Abstract］　Objective　To observe the clinical effect of liraglutide on newly diagnosed type 2 diabetes mellitus, and to investigate the effects of liraglutide on the patients′ blood glucose, blood lipid and body mass index（BMI）.Methods　During January 2016 and May 2017, 20 inpatients with type 2 diabetes mellitus received liraglutide treatment for 4 weeks. During the period of liraglutide treatment, liraglutide was subcutaneously injected to the patients at 0.6 mg/d during the first week and the dosage was increased to 1.2 mg/d during the second week and the dosage of 1.2 mg/d was maintained to the end of the treatment. The changes of blood glucose, blood lipid and BMI were observed before and two and four weeks after treatment.Results　Compared with those before treatment, FBG and PBG decreased two weeks after treatment(P<0.05), and TG, LDL, BMI, FBG and PBG decreased four weeks after treatment(P<0.05). There were no significant changes in TC, HDL, FINS and PINS before and two and four weeks after treatment.Conclusion　Liraglutide has significant short-term hypoglycemic and hypolipidemic effects on the patients with newly diagnosed type 2 diabetes, especially on the obese patients with diabetes.]]> 2018/5/30 8:21:22 LI Jian-ying 172true ［Abstract］　Objective　To explore the clinical characteristics of incomplete Kawasaki disease(KD) complicated with mycoplasma pneumoniae infection and herpangina and to improve the diagnosis of this disease.Methods　The clinical data of one case with incomplete KD complicated with mycoplasma pneumoniae infection and herpangina were analyzed and the related literature was reviewed.Results　Mycoplasma pneumoniae infection was similar to incomplete KD clinically. The clinical symptoms of herpangina interfered with the diagnosis of Kawasaki disease.Conclusion　Although the incomplete KD complicated with mycoplasma pneumoniae infection and herpangina is rare, more attention should be paid to it when 2 or 3 manifestations of KD are shown in the patients, and the related examinations should be taken to prevent the complications and to reduce the missed diagnosis and mortality.]]> 2018/5/30 8:21:22 DING Wen-ling, LIU Ren-chang 171true ［Abstract］　Objective　To investigate the imaging features of cavernous hemangiomas in cavernous sinus, and to analyze the value of magnetic resonance imaging（MRI） in diagnosis of cavernous hemangiomas in cavernous sinus.Methods　MRI findings of 12 patients with cavernous hemangiomas in cavernous sinus who were operated on in our hospital from January 2009 to January 2017 were analyzed retrospectively.Results　In the 12 cases, TIWI showed equal and slightly low signal, and T2WI showed high signal. The results of enhanced scan showed obvious enhancement, lesions in dumbbell shape with clear boundary, internal carotid artery wrapped, adjacent brain tissue compression, and no edema signals.Conclusion　MRI plays an important role in the diagnosis of cavernous hemangiomas in the cavernous sinus.]]> 2018/5/30 8:21:22 GU Li, TENG Yan-hua, JIANG Wen-ping, et al. 170true ［Abstract］　Objective　To investigate the clinical effect of metformin combined with ethinylestradiol and cyproterone acetate tablets in treatment of polycystic ovary syndrome.Methods　The data of 57 patients with polycystic ovary syndrome were collected in our hospital from July 2014 to February 2016 and were retrospectively analyzed. The patients were randomly divided into the observation group(n=30) and the control group(n=27). The control group was treated with ethinylestradiol and cyproterone acetate tablets, and the observation group was treated with ethinylestradiol and cyproterone acetate tablets plus metformin.Results　The ovulation rate and pregnancy rate of the observation group were higher than those of the control group(93.33% vs 81.48%,83.33% vs 55.56%). After treatment, the improvements of sex hormones in the observation group were significantly better than those in the control group(P<0.01). No obvious adverse reactions were found in the two groups.Conclusion　Metformin combined with ethinylestradiol and cyproterone acetate is effective in treatment of polycystic ovary syndrome. It can better improve the level of sex hormones and improve the ovulation rate and pregnancy rate in the patients.]]> 2018/5/30 8:21:22 TANG Ting-ting 169true ［Abstract］　Objective　To observe the curative effect and safety of triamcinolone acetonide combined with 5-fluorouracil in treatment of keloid.Methods　120 keloid patients were randomly divided into the treatment group and the control group, with 60 cases in each group. The patients in the treatment group were treated with triamcinolone acetonide combined with 5-fluorouracil and lidocaine hydrochloride. The patients in the control group were treated with triamcinolone acetonide and lidocaine.Results　After treatment, the clinical effect of the treatment group was significantly better than that of the control group. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. The recurrence rate of the treatment group was significantly lower than that of the control group（P<0.05）.Conclusion　Triamcinolone acetonide combined with 5-fluorouracil has markedly clinical effect and less recurrence in the treatment of keloid.]]> 2018/4/27 7:59:26 QI Shi-ling, ZHU Ding-heng, AO Xian, et al. 168true ［Abstract］　Objective　To explore the effect of postauricular revolving door island flap for repairing anterior auricularl defect.Methods　6 cases with anterior auricularl skin or skin and cartilage defect were repaired with postauricular revolving door island flap in our department from July 2014 to July 2016, and their clinical effects were retrospectively analyzed.Results　After a follow-up of 2 months to 1 year, all the flaps survived completely with primary healing, and the flaps matched to the skin color and texture. The patients were satisfied with the operations.Conclusion　The reconstruction of anterior auricular defect with postauricular revolving door island flap is not only fast-acting and reliable, but also satisfying in both function and aesthetics, which is an effective measure of repairing anterior auricular defect.]]> 2018/4/27 7:59:26 HUANG Xiao-ting, HUANG Jian-Min 167true ［Abstract］　Objective　To explore the effect of apatinib combined with radiotherapy on nasopharyngeal carcinoma in nude mice of CNE-2 and its possible mechanisms.Methods　An experimental model of transplanted tumor in CNE-2 nude mice was established and the model mice were randomly divided into four groups: the control group, the apatinib group, the single radiotherapy group and the apatinib combined with radiotherapy group. The changes of tumor volume were observed after treatment in each group, and the inhibition rate and the combined effect Q were calculated. PET/CT scan was used for detection of T/M values and immunohistochemistry for the expression of CD31.Results　The tumor inhibition rate of the apatinib combined with radiotherapy group was significantly higher than that of the other groups(P<0.05), and the combined effect Q was 1.156 in the apatinib combined with radiotherapy group, suggesting that apatinib had synergistic effect with radiotherapy. T/M values and the expression of CD31 in the apatinib combined with radiotherapy group were the lowest, with significant differences between the apatinib combined with radiotherapy group and the other groups(P<0.05).Conclusion　Apatinib combined with radiotherapy has a synergistic anti-tumor effect on nasopharyngeal carcinoma.]]> 2018/4/27 7:59:26 LIU Shan-shan, SHANG Chang-ling, HAN Yun-wei, et al. 166true ［Abstract］　Objective　To evaluate the reliability of nipple stimulation for induction of labour in patients with previous caesarean section and premature rupture of membranes（PROM） and the pregnancy outcomes.Methods　A retrospective clinical study of 40 parturients was conducted from January 2012 to November 2016 in the First People′s Hospital of Fangchenggang City, who were diagnosed as previous caesarean scar with premature rupture of membrane. The 40 delivery women were divided into two groups according to different treatment methods. The trial of labour after caesarean group(TOLAC group, n=20) and elective re-caesarean section group(ERCS group, n=20) were selected with informed and written consent for induction of labour with nipple stimulation and request for caesarean delivery respectively. The effects of nipple stimulation for induction of labour and the clinical factors of effective induction of labour and the pregnancy outcomes were evaluated and compared between VBAC group and ERCS group.Results　(1)For Bishop′s Score>6, the success rate of induction by nipple stimulation was 66.7%, 5 out of 9 patients had uterine contraction within 6 hours of intervention. The VBAC rate was 90.9% where 54.5% of the pregnant women with successful induction by nipple stimulation received oxytocin during the progress of labor due to uterine atony. (2)Significant differences were observed in age, pre-pregnancy BMI and Bishop score between the successful TOLAC group and the unsuccessful TOLAC group(P<0.01). (3)The amount of postpartal hemorrhage, duration of antibiotic use and hospital stay in VBAC group were significantly less than those in ERCS group(P<0.01). No severity and complications were observed in both of the two groups probably because of the small sample sizes.Conclusion　The effect of nipple stimulation is still unclear on induction of labor. The success rate of induced labor is higher in young non-obese pregnant women with Bishop′s score>6. During labour, more than half of patients need oxytocin to increase the uterine contraction which consists of the risk of TOLAC complications. Oxytocin is a safe drug for induction of labour with strict monitoring and availability of emergency cesarean section facility.]]> 2018/4/27 7:59:26 SU Sha, ZHONG Qi-juan, HUANG Qiu-rong 165true ［Abstract］　Objective　To explore the clinical significance of panoramic ultrasound biomicroscope in selection of operative methods and evaluation of treatment for senile cataract.Methods　152 eyes in 116 elderly patients with senile cataract were examined by panoramic ultrasound biomicroscope, and the patients were treated with phacoemulsification with intraocular lens implantation or the above surgery plus goniosynechialysis according to the existence of closure or stenosis of anterior chamber angle. The changes of anterior chamber angle, depth of anterior chamber and intraocular pressure were compared before and after surgery.Results　The visual acuity of all the patients was statistiacally higher after surgery. The pre-operative visual acuity was higher than 0.3 in 0 eye(0.00%), 0.1～0.3 in 46 eyes(30.26%) and lower than 0.1 in 106 eyes(69.74%). After surgery, the visual acuity was improved, higher than 0.3 in 100 eyes(higher than 0.5 in 53 eyes), between 0.1～0.3 in 39 eyes，and lower than 0.1 in 13 eyes. The mean intraocular pressure was (15.69±5.68)mmHg before surgery and (13.02±3.47)mmHg after surgery(P>0.05). The anterior chamber angles of all eyes became significantly wider after surgery. The mean anterior chamber depth was (1.94±0.33)mm pre-operatively and (3.45±0.27)mm(P<0.05) post-operatively. The mean angle of central anterior chamber(AA) was (21.63±5.65)° before surgery and (33.01±5.64)° after surgery(P<0.05). The mean anterior chamber angle open depth(AOD₅₀₀) was (331±135)μm before operation and (516±123)μm(P<0.01) after operation.Conclusion　Pre-operative application of panoramic ultrasound biomicroscope helps to locate the abmormal anterior chamber angle, direct the plan of surgery, reduce the complications and enhance the safety in treatment of cataract in elderly patients.]]> 2018/4/27 7:59:26 SONG Xue-ying, QI Shao-wen, HU Chang-e, et al. 164true ［Abstract］　Objective　To investigate the effects of high flux hemodialysis(HFHD) combined with tea polyphenols on oxidative stress and nutritional status in diabetic nephropathy(DN) patients with maintenance hemodialysis(MHD).Methods　61 patients with DN who received MHD treatment were collected and were divided into the combination group(n=30) and the control group(n=31) according to the random number table. The control group was treated with HFHD for 3 months and then treated with HD for the next 3 months. The combination group was treated with oral tea polyphenols tablets during the same period when the paients were treated with HFHD and HD. The changes of oxidative stress indexes(blood MDA, SOD, T-AOC) and nutritional indexes(hemoglobin, albumin and grip strength) were compared between the two groups before and 3, 6 months after treatment.Results　The levels of MDA decreased at the end of 3 months after treatment and increased at the end of 6 months after treatment.The levels of SOD and T-AOC increased firstly and then decreased 3, 6 months after treatment.The levels of MDA in the combination group were significantly lower than those in the control group 3 and 6 months after treatment. The levels of SOD and T-AOC were significantly higher than those in the control group(P<0.05). The levels of hemoglobin and albumin and handgrip strength increased firstly and then decreased in the two groups 3 and 6 months after treatment. The levels of hemoglobin and albumin and handgrip strength in the combination group were significantly higher than those in the control group 3 and 6 months after treatment(P<0.05).Conclusion　HFHD combined with tea polyphenols can effectively improve the oxidative stress state of MHD patients with DN, improve their nutritional status, whose clinical effect is better than that of single HFHD or HD.]]> 2018/4/27 7:59:26 YANG Ke 163true ［Abstract］　Objective　To investigate the clinicopathological features, immunohistochemical characteristics, diagnosis and differential diagnosis of granular cell tumor(GCT) of the breast.Methods　The clinical and pathological profiles of 6 cases with GCT of the breast were retrospectively analyzed. The clinical manifestation, morphological features, immune phenotype, diagnosis and differential diagnosis of breast GCT were summarized in combination with the review of literature.Results　One patient was male and five were female. Their age ranged from 21 to 60 years(mean=44.3 years). The study included 5 cases of benign granular cell tumor(BGCT) and 1 atypical granular cell tumor(AGCT). The tumors typically presented as a solitary oval nodule with unclear border in the breast parenchyma. The tumor size ranged from 1.5 to 4.5 cm(mean size=2.5 cm). Microscopically, the tumors were composed of nests or sheets of round to polygonal cells with abundant eosinophilic granular cytoplasm by an infiltrating growth pattern. The nuclei were small, round to oval, with visible nucleoli, and mitosis being absent. Immunohistochemical study demonstrated that tumor cells were possitive for Vimentin, S-100, NSE, CD68 and α-Inhibin, but negative for AE1/AE3, ER, PR, Her-2 and SMA.Conclusion　GCT of the breast is a rare tumor, most of which is benign tumor that may be misdiagnosed as malignancy(such as apocrine carcinoma, acidophilic cell carcinoma and invasive lobular carcinoma etc.) by clinicians, in frozen sections or in cytological tests. HE morphology and immunohistochemistry are applied to make definitive diagnosis of the breast GCT. In order to select the right surgical method, the awareness of this disease should be strengthened and the multidisciplinary preoperative assessment as well as the close postoperative follow-up should be performed.]]> 2018/4/27 7:59:26 YANG Juan, ZHAO Lu, LIU Chun-mei, et al. 162true ［Abstract］　Objective　To explore the diagnosis and treatment of electronic endoscopy, endoscopic ultrasonography(EUS), and pathological features in the patients with gastric ectopic pancreas(GEP).Methods　The clinical data of 42 patients with GEP in our hospital from April 2014 to January 2017 were collected. The results of electronic endoscopy, EUS, pathological features, diagnosis and treatment were analyzed.Results　The electronic gastroscope results showed 11 cases with ectopic pancreas(26.2%); 29 cases with submucosal tumor(69.0%), and 2 cases with stromal tumor(4.8%). The coincident rate between the result of EUS and that of pathological diagnosis was high. The coincidence rate of GEP to acinar cell-based EUS hypoechoic focus was 92.3%, while the catheter tissue or fat cells manifested in higher echo lesion rate was 50.0%. The coincidence rate of internal hypoechoic lesions mainly with local high echo corresponding to a large number of pathological features of acinar cells with focal vascular tissue or adipose tissue was 85.7%. No complications and recurrence occurred after the endoscopic therapy. There were no obvious changes in the ultrasonic gastroscope results in the untreated patients.Conclusion　There is a higher coincidence rate of the diagnosis of EUS performance and pathological results. EUS conduces to the diagnosis of GEP. No complications and recurrence occurr after the endoscopic therapy. Endoscopic therapy can be performed on the needed patients after active communication with them.]]> 2018/4/27 7:59:26 WANG Jing, DANG Tong, MENG Xian-mei, et al. 161true ［Abstract］　Objective　To investigate the effect of rituximab combined with rosuvastatin on cholesterol metabolism in the patients with acute coronary syndromes and low-density lipoprotein cholesterol.Methods　A total of 210 patients with acute coronary syndromes and low-density lipoprotein cholesterol were divided into the control group(treated with rosuvastatin) and the observation group(receiving ezetimibe combined with rosuvastatin) from February 2016 to February 2017 by the random number table method, with 105 cases in each group. The cholesterol metabolism effects were compared between the two groups after a continuous treatment for 12 weeks.Results　There was no significant difference in the total incidence of adverse reactions between the observation group(6.67%) and the control group(4.76%). There were no significant differences in the indexes of cholesterol metabolism between the two groups before treatment(P>0.05). After treatment, the improvement of the indexes of cholesterol metabolism in the observation group was better than that in the control group(P<0.05).Conclusion　Ezetimibe combined with rosuvastatin improves cholesterol metabolism better and may be used as a preferred regimen in the patients with acute coronary syndromes and low-density lipoprotein cholesterol.]]> 2018/3/28 17:03:21 BU Rong-sheng, DU Xin-qing, WU Chun-chun 160true ［Abstract］　Objective　To compare the efficacy of InterTan internal fixation and proximal femoral anatomical locking plate(PFLP) in the treatment of subtrochanteric fractures of femur.Methods　The clinical data of sixty-five cases of subtrochanteric fracture treated with InterTan or PFLP from February 2011 to February 2016 were analyzed retrospectively. The operation time, blood loss, hospitalization time, fracture healing time, limb full weight-bearing time, Harris hip scores of postoperative 1 month, 3 months, 6 months and 12 months and postoperative complications were compared between the two groups.Results　Sixty-five cases were followed up for 16～26(21.80±2.51)months. The operation time and blood loss in InterTan group were significantly less than those in PFLP group(P<0.05). There were no significant differences between the two groups in hospitalization time, fracture healing time, and limb full weight-bearing time(P>0.05). The Harris hip scores of InterTan group were significantly higher than those of PFLP group 1 and 3 months after the operation(P<0.05), but there were no significant differences in Harris hip scores of 6 and 12 months after operation between the two groups(P>0.05).Conclusion　Both InterTan and PFLP internal fixation can be used as an effective method for the treatment of subtrochanteric fractures of the femur. However, InterTan has shorter operation time, less amount of blood loss, slighter postoperative pain and earlier postoperative functional recovery than PFLP.]]> 2018/3/28 17:03:21 HUANG Wen-wen, YIN Dong, HUANG Yu, et al. 159true ［Abstract］　Objective　To explore the curative effect of self-made integrated irrigation and drainage tube on treatment of postoperative infection of humeral fractures.Methods　A retrospective analysis was performed on 23 patients who received the lavage therapy with self-made irrigation and drainage tubes during October 2011 and October 2016, among whom there were 16 males and 7 females, aged 18～62 years(a mean of 38.2 years). The fracture sites included surgical neck of humerus in 7 cases, humeral shaft in 13 cases and humeral supracondylar in 3 cases. All of the cases were dislodged or replaced fixation after debridement, then irrigated to a great extent. The irrigation results and wound healing were observed during treatment.Results　After a follow-up of 1 to 2 years, 19 cases were cured, 1 markedly effective, 1 effective and 2 ineffective, with an effective rate reaching 91.3%.Conclusion　Removal of the internal fixator and thorough debridement，continuous irrigation and suction are effective measures to control infections after internal fixation of humeral fracture.]]> 2018/3/28 17:03:21 ZHOU Dong-ming, AO Ye, ZHANG Hai-dong, et al. 158true ［Abstract］　Objective　To investigate the diagnosis and treatment of abdominal cocoon.Methods　The clinical data of 20 cases with abdominal cocoon treated in our hospital from January 2012 to June 2017 were collected and analyzed.Results　The main clinical features of abdominal cocoon were complete or incomplete intestinal obstruction(65.0%) and abdominal mass(40.0%). Computed tomography(CT) showed thickened, mustered and disordered bowel wall in 10 cases. Abdominal X-ray showed bowel dilatation with obvious air-fluid level in 8 cases. Gastrointestinal series(barium meal) showed proximal small bowel dilatation, disorder of part bowel and fixed at mid-abdomen in 4 cases. All the patients underwent surgical treatment, among whom 8 cases suffered from postoperative complications(40.0%), 3 cases suffered from intestinal obstruction(15.0%), 3 cases suffered from incisional infection(15.0%), 1 case suffered from anastomotic fistula(5.0%) and 1 case died of multiple organ dysfunction syndrome(MODS)(5.0%).Conclusion　Clinical features of abdominal cocoon are not typical, and preoperative diagnosis could be difficult. CT and gastrointestinal imaging provide great value for preoperative diagnosis. The treatment mainly focuses on surgery, and the incidence of postoperative complications is high.]]> 2018/3/28 17:03:21 ZHANG Qiang, ZHU Xiao-cheng 157true ［Abstract］　Objective　To observe the clinical effect of Zengyejiedu decoction on acute radioactive oral mucositis in the patients with head-neck malignant carcinoma.Methods　118 patients who were diagnosed with head-neck malignant carcinoma in the department of oncology of Dazhou center hospital from March 2015 to July 2016 were randomly divided into the experimental group(n=59) and the control group(n=59). All the patients received concurrent radiochemtherapy, the experimental group was treated with oral Zengyejiedu decoction, while the control group received conventional gargle. The clinical effect on the treatment of acute radioactive oral mucositis was compared between the two groups.Results　(1)With the dosage of radiation reaching 20 Gy, mucosa reaction appeared to some extent in some patients in the experimental group(25.86%) and the control group(44.64%); (2)After the radiation, the incidence of oral mucosa reaction was 56.90% in the experimental group, and 71.43% in the control group, the incidence of reaction on level 3, 4 in the control group(17.86%) was higher than that in the experimental group(6.90%); (3)The percentage of delayed radiotherapy in the control group(28.57%) was higher than that in the experimental group(15.52%); (4)The percentage of the patients who were treated with other interventional therapies in the control group(30.36%) was significantly higher than that in the experimental group(13.79%).Conclusion　Zengyejiedu decoction can improve the patients′ radiation tolerance, release the acute oral mucosa reaction caused by radiation, and improve the quality of life.]]> 2018/3/28 17:03:21 SONG Zhu-mei, SONG Hong-mei, GUI Jin-chuan, et al. 156true ［Abstract］　Objective　To explore the curative effect of total hip arthroplasty(THA) on treatment of ankylosing spondilitis and hip ankylosis.Methods　A total of 12 cases(20 hips) with ankylosing spondylitis and hip joint stiffness underwent total hip arthoplasty from January 2010 to January 2015. Harris scores and hip range of motion were compared before and after the operation.Results　All patients were followed up from 24 months to 84 months(mean 48.5 months）. No incision-related complications were found. There were no prostheses migration and aseptic loosening. Joint dislocation occurred in one case and injury of sciatic nerve in one case. Heterotopic bone formation with Brooker I was found in 2 hips, Brooker Ⅱ in 2 hips, and Brooker Ⅲ in 1 hip. The Harris scores increased from (20.6±13.1) preoperatively to (71.9±9.3) postoperatively. The hip function improved significantly after the operation. The hip mean flexion range increased from (12.9±5.6)° preoperatively to (75.6±19.6)° postoperatively, and the mean range of abduction of hip joint increased from (4.4±2.7)° preoperatively to (24.5±8.6)° postoperatively.Conclusion　THA can greatly improve the hip joint function and rectify the deformity of the hip joint in the patients with ankylosing spondilitis and hip ankylosis.]]> 2018/3/28 17:03:21 GAN Feng-ping, JIANG Jian-zhong, TAN Hai-tao, et al. 155true ［Abstract］　Objective　To explore the clinical effect of disposable incision retractor fixator on open thyroid surgery.Methods　The clinical data of 206 patients who were performed open thyroid surgery were retrospectively analyzed, of whom, disposable incision retractor fixator was used in 82 cases, and was not used in the other 124 cases. The number of the patients who received the operation, the time of operation, the amount of blood during the operation and the postoperative bleeding were compared between the two groups.Results　There were significant differences in the number of the patients who received the operation, the time of operation and intraoperative blood loss between the two groups(P<0.05). There were no significant differences in the postoperative drainage volume and postoperative bleeding(P>0.05).Conclusion　Application of disposable incision retractor fixator can reduce the patients receiving the operation, shorten the operation time and reduce the amount of intraoperative blood loss in open thyroid surgery.]]> 2018/3/28 17:03:21 CHEN Xin-qi, LI Li-bo, CAI Yong-chang, et al. 154true ［Abstract］　Objective　To compare the clinical effects of long proximal femoral nail anti-rotation(PFNA) and proximal femur locking plate on the treatment of subtrochanteric fracture.Methods　The clinical data of 65 patients with subtrochanteric fracture in our hospital from September 2011 to August 2015 were retrospectively analyzed, among whom 31 cases received long PFNA and 34 cases were treated with proximal femur locking plate. The operation time, intraoperative blood loss, full weight bearing time, fracture healing time and neck-shaft angle discrepancy were analyzed. The femoral head function was assessed by Harris scores system 6 months after the operation.Results　The average follow-up period was 16 months(ranges from 11 to 25). There were no significant differences between the long PFNA group and the proximal femur locking plate group in the general condition and Harris scores（P>0.05）. The long PFNA group had shorter operation time, full weight bearing time and fracture healing time, less intraoperative blood loss and less neck-shaft angle discrepancy than the proximal femur locking plate group.Conclusion　Long PFNA has the advantages of less invasion and intraoperative blood loss, earlier walk,firmer fixation and better clinical effect than the proximal femur locking plate in the treatment of subtrochanteric fracture.]]> 2018/3/2 17:10:11 ZUO De-ling, YIN Dong, CHEN Xiong, et al. 153true ［Abstract］　Objective　To evaluate the effect of high-dose atorvastatin on carotid intima-media thickness(IMT) in hypertensive patients.Methods　125 patients with primary hypertension complicated with carotid plaques were randomly divided into the treatment group and the control group. The treatment group(n=62) received routine antihypertensive therapy plus high dose of atorvastatin 40 mg/d, and the control group(n=63) received routine antihypertensive therapy plus atorvastatin 10 mg/d. The patients were dynamically monitored before and 6 months after treatment. The changes of diastolic blood pressure, systolic blood pressure, triglyceride(TG), serum total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C) and carotid IMT were observed.Results　After treatment, the levels of LDL-C, TC and TG in the treatment group and the control group decreased, but the rate of decline in the treatment group was greater than that in the control group(P<0.01). After treatment, the thickness and length of carotid IMT were reduced in both of the two groups, however the reduced values in the treatment group was greater than those in the control group(P<0.01).Conclusion　Large doses of atorvastatin have a significant effect on reducing carotid IMT and blood lipids, and inhibiting atherosclerosis in hypertensive patients.]]> 2018/3/2 17:10:11 LI Xu-dong, YANG Yun, SU Zhi-qiang 152true ［Abstract］　Objective　To investigate the application of carbon nanoparticles in reoperation of differentiated thyroid carcinoma(DTC) surgery.Methods　The clinical data of 95 patients who were performed reoperation of DTC in our department from July 2012 to July 2016 were retrospectively analyzed. The patients were divided into the carbon nanoparticles group(n=50) and the control group(n=45). The number of lymph nodes of dissection and metastasis, the cases of identify and mistaken cutting parathyroid glands, the operation time, parathyroid function, superior laryngeal nerve and recurrent laryngeal nerve injury were compared between the two groups.Results　The number of lymph nodes of dissection and metastases in the carbon nanoparticles group was more than that in the control group(P<005). The number of parathyroid identified during the operation was more and the number of cutting parathyroid glands by mistake was less in the carbon nanoparticles group than those in the control group(P<0.05). The operation time and postoperative complications, the incidence of transient hypoparathyroidism, superior laryngeal nerve and recurrent laryngeal nerve injury in the carbon nanoparticles group were less than those in the control group(P<005).Conclusion　Application of carbon nanopartieles can improve the detection rate of lymph nodes and the rate of thorough dissection, protect the parathyroid glands and nerves and reduce the operation time in the reoperation of DTC.]]> 2018/3/2 17:10:11 AI Yong-biao, LI Meng, WANG Ming-hua 151true ［Abstract］　Objective　To analyze the prevalence of skin tumors in primary hospital.Methods　232 patients with pathological diagnosis as skin tumors were collected in our hospital from January 2011 to December 2016, and their clinical and pathological data were classified and analyzed.Results　(1)There was no significant difference in the rate of the benign or malignant tumors between male and female patients. (2)According to the origins of the tissue organization, the epidermal tumors were the most common, followed by melanocytic tumors. (3)The largest number of skin tumors was as follows: seborrheic keratosis, basal cell carcinoma, nevus, dermatofibroma and Bowen′s disease. (4)The coincidence rate of clinical diagnosis and pathological diagnosis is about 52.59%. (5)The age of the patients with malignant tumors was significantly higher than that of the patients with benign tumors（P<0.01）. (6)The exposed parts were more likely to occur malignant tumors or borderline tumors.Conclusion　The epidermal and melanocytic tumors are common skin tumors in the patients who received biopsy in our hospital. The rate of pathological examination and the coincidence rate of clinical diagnosis and pathological diagnosis are low. The clinicians, especially from primary hospitals, should pay more attention to the biopsy,especially the tumors at the place of exposed locations in the elderly patients.]]> 2018/3/2 17:10:11 MEI Ce-fang, LI Juan, LI Gao-feng, et al. 150true ［Abstract］　Objective　To investigate the clinical effect of reteplase combined with enoxaparin in the treatment of acute ST-elevation myocardial infarction(ASTEMI).Methods　A total of 90 patients with ASTEMI were enrolled in our hospital from January 2014 to January 2016, and were randomly divided into the control group(n=45) and the study group(n=45). Both groups were treated with conventional therapy. Besides the conventional therapy,the control group was treated with urokinase plus enoxaparin, and the study group was treated with reteplase plus enoxaparin. The recanalization rate of infarcted arteries, and the incidence rates of complications and mortality were observed at 30 min, 60 min and 90 min after the treatment.Results　The recanalization rates of infarcted arteries in the study group were 44.44%, 51.11% and 57.78% at 30 min, 60 min and 90 min after the treatment respectively, and the corresponding indicators mentioned above in the control group were 22.22%, 28.89% and 35.56%, with significant differences between the two groups（P<0.05）. The incidence of bleeding in the study group(4.44%) was significantly lower than that in the control group(17.78%), P<0.05. After one year of follow-up, the mortality rate of the study group(4.44%) was significanthy lower than that of the control group(17.78%)(P<0.05).Conclusion　Reteplase combined with enoxaparin has satisfactory curative effect on ASTEMI. It can effectively improve the recanalization rate of the infarcted artery, and reduce the rates of bleeding and mortality.]]> 2018/3/2 17:10:11 YANG Bin 149true ［Abstract］　Objective　To evaluate the feasibility and clinical value of laparoscopic assisted duodenum-preserving and pancreatic head resection.Methods　The clinical data of one patient with solid pseudopapillary neoplasm of the pancreas treated by laparoscopic assisted subtotal resection of the duodenum and pancreas in our hospital in August 2015 were retrospectively analyzed.Results　The operation time was about 185 min, and the intraoperative blood loss was 100 ml. No blood transfusion was performed during the operation, and the vital signs were stable after the operation. The volume of drainage was 150 ml at its maximum three days after the operation, and the drainage tube was removed on the seventh postoperative day. The patient′s condition was stable and recovered well ten days after the operation.Conclusion　Laparoscopic assisted duodenum-preserving and pancreatic head resection is safe and feasible for the treatment of solid pseudopapillary neoplasm of the pancreas.]]> 2018/3/2 17:10:11 YU Jie, ZHANG Yong-ping, LIU Jian-sheng, et al. 148true ［Abstract］　Objective　To investigate the clinical outcomes of arthroscopy for diagnosis and treatment of knee gouty arthritis in elderly patients.Methods　From May 2011 to May 2016 in our hospital, the clinical data of 45 elderly patients with knee gouty arthritis in 49 knees were retrospectively analyzed. All the patients received examination and debridement simultaneously under arthroscopy. Both drug and dietary therapy were performed during the perioperative period. The clinical outcomes, including Visual Analogue Scores, range of motion and Lysholm knee scores were evaluated.Results　Knee gouty arthritis was diagnosed by arthroscopy and pathology in all the cases. 39 cases with arthritis in 41 knees were followed up from 11 months to 5 years. The symptoms disappeared or improved in 36 cases with a good and excellent rate of 84.6%.Conclusion　Arthroscopy is an effective method for diagnosis and treatment of knee gouty arthritis in elderly patients, with which pain relief and function improvement can be achieved through synovectomy and removement of the urate crystal.]]> 2018/1/26 9:57:02 SHI Ze-feng, SUN Ke 147true ［Abstract］　Objective　To explore the different FACED scores in the patients with different times of acute exacerbation of chronic obstructive pulmonary disease(COPD) complicated with bronchiectasis.Methods　According to the FACED scores, the clinical data of 81 patients with COPD complicated with bronchiectasis,including age, gender, clinical symptoms, HRCT, bacteria, pulmonary function, CRP and blood gas analysis(PO₂, PCO₂), serum albumin, times of the acute exacerbation(outpatient and hospitalization) during 1 year of the follow-up were retrospectively analyzed.Results　The times of acute exacerbation during 1 year of the follow-up in the 5～7 FACED scores group(8.46±2.10) were more than those in the 3～4 FACED scores group(6.62±2.41) and the 0～2 FACED group(2.92±1.49)(P<0.05). The FACED scores were positively correlated with the times of acute exacerbation(r=0.753).Conclusion　The more the FACED scores are, the more times of acute exacerbation in the patients with COPD complicated with bronchiectasis. The FACED scores are usefull to diagnose and treat acute exacerbation of COPD.]]> 2018/1/26 9:57:02 ZHANG Can-hui, PENG Zhi-wen, WU Jian-hui, et al. 146true ［Abstract］　Objective　To explore the efficacy and safety of uterine arterial embolization(UAE) in the treatment of intractable postpartum hemorrhage(PPH）.Methods　The clinical data of 10 cases with intractable PPH were retrospectively reviewed in Wuhan Children′s Hospital(Wuhan Maternal and Child Healthcare Hospital) from January 2014 to December 2016. All the patients were treated with UAE after failure of the other traditional treatment methods.Results　All the cases were successfully treated with UAE without complications.Conclusion　UAE is a safe and effective method of controlling intractable PPH without serious complications.It is suitable for the patients in case of the failure of the other conservative treatments.]]> 2018/1/26 9:57:02 LIU Jiu-ying, WANG Lin, SONG Xiao-jie, et al. 145true ［Abstract］　Objective　To explore a better premedication procedure of low dosage of dexamethasone to prevent the allergic reaction of paclitaxel.Methods　374 patients who were expected to be able to complete 4 cycles of paclitaxel combined with cisplatin chemotherapy regimen were collected from April 2014 to July 2016,of whom 356 patients were actually enrolled in this study. They were randomly divided into group A and group B. Group A(n=180) received dexamethasone 7.5 mg orally at 10:00 in the evening and 6:00 in the next morning and were injected with dexamethasone 5 mg via vein 30 minutes earlier before injection of paclitaxel. Group B(n=176) were injected with dexamethasone 10 mg via vein 30 minutes earlier before injection of paclitaxel. The rates of allergic reactions and other common adverse reactions were compared between the two groups.Results　The majority of the allergic reactions happened in the first two chemotherapy cycles and the incidence rates were 85.7% and 81.5% in group A and group B respectively(P>0.05). The allergic reactions of grade 4 or 5 didn′t occur in the two groups. The number of the patients suffered from allergic reactions of grade 1, 2 or 3 was 11, 7 or 0 and 12, 8 or 5 in group A and group B respectively(P>0.05). The peripheral neuritis of grade 4 or 5, the muscle and joint pain of grade 4, the nausea and vomiting of grade 4 didn′t occur in the two groups. The number of the patients suffering from peripheral neuritis of grade 1, 2 or 3 was 45, 26 or 6 and 39, 30 or 9 in group A and group B respectively(P>0.05). The number of muscle and joint pain of grade 1, 2 or 3 was 47, 24 or 17 and 40, 31 or 20(P>0.05) and the number of nausea and vomiting of grade 1, 2 or 3 was 29, 17 or 6 and 34, 21 or 11(P>0.05) in group A and group B respectively. The number of the patients suffering from increasing of fasting blood-glucose was 8 and 1（P<0.05） and the number of insomnia was 17 and 5（P<0.05） in group A and group B respectively.Conclusion　Premedication procedure of low dosage of dexamethasone may be a better choice for the patients with allergic reaction of paclitaxel.]]> 2018/1/26 9:57:02 DONG Bo-sheng, XU Ke-you, ZUO Cai-ying 144true ［Abstract］　Objective　To study the effects of subtotal gastrectomy combined with duodenojejunostomy on treatment of giant duodenal stasis.Methods　The clinical data of 33 patients with giant duodenal stasis receiving the operation of subtotal gastrectomy combined with duodenojejunostomy in our hospital from January 2000 to December 2015 were retrospectively analyzed.Results　All the patients were treated with subtotal gastrectomy combined with duodenojejunostomy. The time of operation was (150±28)min. The bleeding volume during surgery was (200±45)ml. The recovery time of the anal discharge bowel function after surgery was (3.5±1.5)d. The hospital stay was (25.3±8.6)d. One case had postoperative duodenal fistula on the second day after the duodenum fistulas were pulled out, however the patient was cured and discharged from the hospital after reoperation. Three cases had incision infection but were cured after wound dressing. Two cases had intestinal obstruction but were cured after conservative treatment. No abdominal abscess and no operative deaths occurred.Conclusion　Subtotal gastrectomy combined with duodenojejunostomy is safe and feasible for the treatment of giant duodenal stasis.]]> 2018/1/26 9:57:02 LI Hui, LI Yun-fu, ZHU Rui-chang 143true ［Abstract］　Objective　To systematically review the effect of modified acupuncture on the treatment of external humeral epicondylitis.Methods　Such databases as Pubmed, Embase, Cochrane Library，CBM, CNKI, VIP and WanFang Data were searched to collect the randomized clinical trials on the effects of modified acupuncture for external humeral epicondylitis. According to the inclusion and exclusion criteria, literature was screened, and the data were extracted, and the methodological quality of included studies was also assessed. Meta-analysis was performed using Revman 5.3 software.Results　13 RCTs were included eventually among a total of 639 cases with modified acupuncture in the treatment of external humeral epicondylitis. The analysis showed that the effect of modified acupuncture in the treatment of external humeral epicondylitis were superior than that of common acupuncture［RR=1.15, 95%CI(1.10,1.21), P<0.00001］; The VAS scores of the group using modified acupuncture were significantly lower than those of the group using common acupuncture［MD=1.18, 95%CI(1.01,1.35), P<0.00001］.Conclusion　The clinical effects of modified acupuncture are superior to those of common acupuncture on the treatment of external humeral epicondylitis. However more researches need to be verified by the data based on high-quality randomized and double-blind multicenter studies.]]> 2018/1/26 9:57:02 HU Lan, LING Min 142true ［Abstract］　Objective　To investigate the prevalence rate of hyperuricemia and the correlation between serum uric acid and lipid metabolism in uremia patients undergoing peritoneal dialysis(PD). Methods　Forty-one PD patients were selected and divided into hyperuricemia group(n=20) and normal uric acid group(n=21). The levels of blood lipid, serum lipoprotein, albumin, glucose, urea as well as creatinine were evaluated. The prevalence of hyperuricemia in the PD patients was investigated and the general information and blood lipid level were compared between the two groups. Meanwhile, the risk factors related to the level of serum uric acid were analyzed. Results　The incidence of hyperuricemia was 48.78% in the PD patients. The levels of TG in the hyperuricemia group were significantly higher than those in the normal uric acid group(P<0.05). There were no significant differences in the serum levels of TC, HDL, LDL and Lipo-a between the two groups(P>0.05). Logistic analysis showed that the level of TG was the risk factor of hyperuricemia in uremia patients undergoing peritoneal dialysis(OR=6.20, P=0.02). Conclusion　The incidence of hyperuricemia is high in the PD patients. The levels of TG in the PD patients with hyperuricemia are significantly higher than those with normal uric acid level. The level of serum uric acid is associated with triglyceride level. More attention should be paid to the level o f serum uric acid in the PD patients.]]> 2018/12/29 16:55:29 GAO Ting-ting, HAO Xiu-ying, YONG Ping, et al. 141true ［Abstract］　Objective　To investigate the clinical effect of endoscope-assisted transsphenoidal approach on treatment of pituitary adenomas. Methods　92 patients with pituitary adenomas treated in our hospital from May 2017 to May 2018 were randomly divided into control group and study group. The control group was treated with pituitary adenoma resection via microscope nasal transsphenoidal resection, and the study group received pituitary adenoma resection by endoscope-assisted transsphenoidal approach. The clinical effects, the endocrine hormone levels and the postoperative complications were compared between the two groups. Results　The clinical effect of the study group was better than that of the control group(P<0.01), and the incidence postoperative complications in the study group was significantly lower than that in the control group(P<0.01). The levels of angiotensin, renin, norepinephrine and other endocrine hormones in the study group were better than those in the control group after treatment(P<0.01). Conclusion　Endoscope-assisted transsphenoidal approach is more effective in the treatment of pituitary adenomas and the impacts of endocrine hormone levels is relatively less.]]> 2018/12/29 16:55:29 KONG Ling-chang, ZHANG Long-zhou 140true ［Abstract］　Objective　To study the clinical eficacy of anterolateral thigh flaps for the reconstruction of large soft tissue defects accompanied with segmental main artery defects in lower extremities. Methods　The clinical data of 15 patients suffering from large soft tissue defects accompanied with segmental main artery defects in lower extremities in our hospital during August 2013 and September 2017 were retrospectively analyzed. All of the patients received debridement and bone fixation among whom 1 case received incomplete amputation in emergency and her flaps were transferred to the bridge blood vessels to restore blood supply, and 14 cases received vacuum sealing drainage(VSD) combined with secondary reconstruction of soft tissue defects with free anterolateral thigh flaps which ranged from 15 cm×10 cm to 30 cm×12 cm. Results　All the patients were followed up, and all of the flaps survived completely. Two cases developed venous thrombosis postoperatively, and the flaps survived after the exploration. The wound healing was delayed in one case because of wound infection. At the time of the latest follow-up, all of the flaps had good appearance and abundant blood supply, without severe complications in the donor sites. The appearance and function of the affected limbs recovered satisfactorily. Conclusion　For the patients suffering from large soft tissue defects accompanied with segmental main artery defects in lower legs, anterolateral thigh flap reconstruction technique is an ideal method to cover the tissue defects and avoid sacrificing major vessels.]]> 2018/12/29 16:55:29 WU Jian, LUO Xu-chao, ZOU Yong-gen, et al. 139true ［Abstract］　Objective　To investigate the risk factors of chronic obstructive pulmonary disease(COPD) accompanied with invasive pulmonary aspergillosis(IPA). Methods　This case control study included 24 patients with COPD accompanied with invasive pulmonary aspergillosis（the observation group） in the Department of Respiratory Medicine of Kaifeng Central Hospital from May 2015 to May 2018. Other 48 COPD patients who hospitalized at the same time and were matched with age(±2 years) and with the ratio of 1∶2 were collected as the control group. Logistic regression analysis was used to evaluated the risk factors of COPD accompanied with IPA. Results　Single factor analysis showed that the significant factors of COPD accompanied with IPA were acute exacerbation of COPD, diabetes mellitus, chronic renal failure, duration of broad-spectrum antibiotic use≥ two weeks and systemic use of steroids(P<0.10). Conditional Logistic regression analysis showed that diabetes mellitus and systemic use of steroids were the independent risk factors of COPD accompanied with IPA(OR=7.384, 6.681, 32.354, P<0. 05). Conclusion　Diabetes mellitus, the duration of broad-spectrum antibiotic use≥two weeks and systemic use of steroids are the independent risk factors of COPD accompanied with IPA.]]> 2018/12/29 16:55:29 AN Yong-peng, LEI Jun-qi 138true ［Abstract］　Objective　To investigate the efficacy of tauroursodeoxycholic acid in treatment of severe jaundice type B viral hepatitis. Methods　Eighty patients with severe jaundice type B viral hepatitis were randomly divided into intervention group and control group, with 40 cases in each group. The control group was given entecavir anti virus, and then treated with glutathione and compound glycyrrhizin. On the basis of routine treatment, the intervention group was given tauroursodeoxycholic acid capsules 250 mg orally, 2 times daily for 14 days. The changes of total bilirubin(TBIL), direct bilirubin(DBIL), alanine aminotransferase(ALT), aspartate aminotransferase(AST) and alkaline phosphatase(ALP) were observed in the two groups before and after treatment. Results　In the two groups, compared with those before treatment, the levels of TBIL, DBIL, ALT, AST and ALP were significantly decreased after treatment(P<0.05), while those in the intervention group were decreased more significantly than those in the control group(P<0.05). Only one patient receiving tauroursodeoxycholic acid had mild symptoms of upper abdominal discomfort. Conclusion　As an adjuvant therapy, tauroursodeoxycholic acid can significantly reduce the total bilirubin(TBIL) and direct bilirubin(DBIL), alanine aminotransferase(ALT) and aspartate aminotransferase(AST) and alkaline phosphatase(ALP) for the patients with severe jaundice type B viral hepatitis.]]> 2018/12/29 16:55:29 WANG Xin-ting, ZHANG Chuan-lei, CHEN Xiao-qi, et al. 137true ［Abstract］　Objective　To study the correlation between emotional quotient(EQ) and emergence agitation（EA） during the recovery period of general anesthesia. Methods　78 patients with general anesthesia were selected from May 2017 to March 2018, and Baron emotional quotient inventory(EQ-I) was used to test EQ before induction of general anesthesia. The patients′ Ricker sedation-agitation scale(SAS) scores were recorded during the recovery period of general anesthesia. SPSS 21.0 statistic software was used to analyze the data. Results　The EQ value was strongly negatively correlated with the SAS scores, and the correlation coefficient of Pearson was -0.626(P<0.01). Conclusion　　The patients with higher EQ are less agitated and the patients with lower EQ are agitated more seriously in the recovery period of general anesthesia.]]> 2018/11/22 14:41:33 PANG Li-xia 136true ［Abstract］　Objective　To explore the clinical effect of elastic stockings combined with enoxaparin sodium and barometric pressure therapy on prevention of postoperative deep vein thrombosis(DVT) in patients with gynecological malignant tumors. Methods　120 patients with gynecological malignant tumors were selected as the research objects in our department from May 2014 to October 2017. The patients were divided into 3 groups: the control group A(n=40) receiving routine nursing measures, the control group B(n=40) receiving the conventional nursing measures plus injection of enoxaparin sodium therapy and the observation group(n=40) receiving the conventional nursing measures plus wearing elastic stockings combined with injection of enoxaparin sodium and barometric pressure therapy. The incidence of deep vein thrombosis was compared among the 3 groups. Results　The incidence rate of DVT was 2.50% in the observation group, 30.00% in the control group A, and 20.00% in the control group B. The incidence rate of the observation group was significantly lower than that of the control group A or than that of the control group B(P<0.05). The incidence of pulmonary embolism was 0.00% in the observation group, 17.50% in the control group A, and 7.50% in the control group B, with a significant difference between the observation group and the control group A(P<0.05). Conclusion　　Wearing elastic stockings combined with injection of enoxaparin sodium and barometric pressure therapy can prevent postoperative deep vein thrombosis in patients with gynecological malignant tumors.]]> 2018/11/22 14:41:33 YU Hong-biao, TANG Jie, DU Min, et al. 135true ［Abstract］　Objective　To investigate the clinical efficacy of percutaneous vertebroplasty(PVP) via target puncture for treatment of symptomatic thoracic vertebral hemangioma(VH). Methods　From February 2010 to February 2016, a total of 13 patients with symptomatic thoracic VH were treated with PVP via target puncture in our hospital and they were enrolled in this retrospective study. This study involved 10 males and 3 females, with mean age of (55.0±9.6)years. There were 8 cases of single thoracic VH, and 5 cases of multiple vertebral hemangiomas. All the cases were diagnosed with VH by postoperative pathological examination. Visual Analogue Scale(VAS) and Oswestry Disability Index(ODI) scores were used to assess the operative results. Results　All the patients were followed up not less than 12 months and their back pain was significantly improved after treatment. The VAS and ODI scores were significantly improved in all the patients 24 hours, 3 months and 12 months after the operation(P<0.05). A slight leakage of bone cement occurred beside vertebras in 2 cases without clinical symptoms and special treatments. There were no complications in the other patients. Conclusion　　PVP via target puncture is a safe and effective minimally invasive treatment method of symptomatic thoracic vertebral hemangioma, especially for relieving the pain.]]> 2018/11/22 14:41:33 ZHANG Bao-liang, OU Xuan-cheng, ZHANG Yong, et al. 134true ［Abstract］　Objective　To characterize the Entamoeba histolytica of 5 cases in feces to avoid missing inspection. Methods　Five stool samples from the patients with Entamoeba histolytica infection but missed diagnosis in the other hospitals were analyzed using normal saline smear, iodine staining and hematoxyline staining under microscopy. Results　The amebic cyst and amebic trophozoite of Entamoeba histolytica displayed unique characteristics by using normal saline smear, iodine staining and hematoxyline staining. Conclusion　　For the patients with suspected intestinal amoeba, stool specimens should be sent to the laboratory repeatedly and timely for analysis. The Entamoeba histolytica should be identified by using different methods. Special attentions must be paid to identify the Entamoeba histolytica and distinguish it from phagocytes and Entamoeba dispar.]]> 2018/11/22 14:41:33 DENG Shuang, ZHAO Hong-ying, WEI Sheng, et al. 133true ［Abstract］　Objective　To investigate the value of nano-carbon tracer technique in ambulatory thyroid surgery. Methods　The clinical data (including general information, previous history, preoperative examination, intra-operative and post-operative diagnosis and treatment measures) of 42 patients treated with carbon nano-carbon technique according to the standard of ambulatory thyroid surgery were retrospectively analyzed to evaluate the intra-operative findings and post-operative complications. Results　42 patients were successfully completed the ambulatory operation procedure and were discharged in time. Conclusion　Nano-carbon tracer is effective and can prevent the occurrence of complications for the patients receiving ambulatory thyroid surgery.]]> 2018/10/26 9:09:11 ZHU Kai, CAO Gang, WANG Hong-bo 132true ［Abstract］　Objective　To investigate the clinical efficacy of chemotherapy combined with HLA-mismatched G-PBSC infusion(microtransplantation) for hematologic malignancies. Methods　13 patients with hematologic malignancies received microtransplantation in our hospital from May 2015 to December 2016 and their clinical data were retrospectively analyzed. According to the different conditions, the 13 patients were treated with different conditioning regimens and then hematopoietic stem cell infusion was performed on them for 3 to 4 times. The recovery time of platelet and neutrophils, the occurrence of acute and chronic graft versus host disease(GVHD) and other adverse reactions were observed. Results　During the follow-up that was conducted to April 2017, 6 cases survived and 2 cases died in the intermediate risk group(n=8); 2 cases survived and 3 died in the high risk group(n=5). The medium survival time was 9 months(4 to 24 months). The recovery time of neutrophil and platelet was 8 days(5 to 14 days) and 11 days(6 to 20 days) respectively after microtransplantation. All the patients had no acute and chronic GVHD during microtransplantation. Conclusion　Microtransplantation is unrestricted in the choice of donors, and the recovery time of platelet and neutrophils is shorter. No cases of GVHD is observed. Large randomized clinical trials of microtransplantation are needed to verify the results in the intermediate-risk and high-risk hematologic malignancies.]]> 2018/10/26 9:09:11 WANG Pan-pan, KA Mao-jia, ZHANG Jin, et al. 131true ［Abstract］　Objective　To compare the clinical efficacy between traditional cholecystectomy+choledocholithotomy and endoscopic retrograde cholangio-pancreatography（ERCP）+endoscopic sphincterotomy（EST） +laparoscopic cholecystectomy（LC） in treatment of cholecystolithiasis complicated with choledocholithiasis. Methods　The basic data of 88 cases of cholecystolithiasis complicated with choledocholithiasis treated in our hospital from September 2016 to September 2017 were analyzed retrospectively. The patients were divided into open cholecystectomy group (n=44) and ERCP+EST+LC group(n=44). The general clinical data, operation time, hospitalization time, hospitalization costs, preoperative and postoperative liver function and postoperative complications were compared between the two groups. Results　There were no significant differences in preoperative AST and preoperative ALT between the two groups(P>0.05), but there were significant differences in the operative time, hospitalization time, hospitalization costs, postoperative ALT and AST, and total preoperative complication rate between the two groups(P<0.05). Conclusion　ERCP+EST+LC is superior to the traditional open choledocholithotomy in the treatment of cholecystolithiasis complicated with choledocholithiasis.]]> 2018/10/26 9:09:11 HOU Jie, WANG Gang, Basangdunzhu, et al. 130true ［Abstract］　Objective　To explore the changes of anti-mullerian hormone（AMH） before and after laparoscopic unilateral ovarian endometriosis cyst removal and its significance. Methods　90 patients with unilateral ovarian endometriosis admitted to the Second Affiliated Hospital of University of South China from January 2016 to June 2017 were selected as the observation group, and other 120 patients with benign ovarian cysts as the control group. Both of the two groups were performed the operation of laparoscopic ovarian cyst extirpation. The serum AMH test results were obtained before operation and 1 week, 3 months and 6 months after operation. Results　The serum AMH expression in the patients of the observation group was significantly lower than that in the patients of the control group(P<0.01). The AMH values decreased after surgery in both groups(P<0.01). The rate of AMH decline in the patients of the observation group was significantly higher than that in the patients of the control group(P<0.01). Conclusion　AMH is decreased in the patients with ovarian endometriosis. Laparoscopic ovarian cyst extirpation affects the ovarian function. The ovarian function is still in recovery 6 months after surgery, especially in the patients with ovarian endometriosis.]]> 2018/10/26 9:09:11 ZHANG Xiao-di 129true ［Abstract］　Objective　To explore the effects of the teaching model of combining problem-based learning(PBL) with case-based learning(CBL) on the teaching of clinical management of bronchiolitis for pediatric interns. Methods　Sixty intern students were randomly selected from the 2013 grade 5-year General Medicine Major at the School of Clinical Medicine of Guilin Medical University and randomly divided into observation group(n=30) and control group(n=30). The traditional teaching model was adopted in the control group. The observation group was adopted the teaching model combining PBL with CBL. The difference of learning effects were compared between the groups of interns before and after teaching. Results　The results of theoretical examination before the teaching reform were excellent in 10, good in 15 and poor in 5. After teaching reform, the results of the theoretical assessment were excellent in 22, good in 8 and poor in 0, and the test group was significantly better than the control group in the diagnosis and treatment of bronchiolitis（P<0.05）. After the reform, the interns understood better the basic knowledge of bronchiolitis, clinical diagnosis and treatment, as well as the risk factors of the disease, prevention and other knowledge points than they did before the teaching reform（P<0.05）. Conclusion　The teaching model combining PBL with CBL is favorable for general medicine interns to thoroughly grasp the diagnosis and treatment of bronchiolitis.]]> 2018/10/26 9:09:11 ZHENG Wei-hua, PENG Juan, SONG Xiao-dan, et al. 128true ［Abstract］　Objective　To observe the expressions of empty spiracles homeobox 2(EMX2),β-catenin and Cyclin D1 in normal colorectal mucosa and colorectal cancer tissues and to investigate the relationship between EMX2 and β-catenin, Cyclin D1 in the development of colorectal cancer. Methods　The immunohistochemical S-P method was used to detect the expressions of EMX2, β-catenin and Cyclin D1 proteins in normal colorectal mucosa and colorectal cancer tissues. The correlations of EMX2,β-catenin and Cyclin D1 and clinicopathologic features in colorectal cancer and the patients′ prognosis were analyzed. Results　(1)The positive rates of EMX2 expression was 76.7% and 38.2% in the normal colorectal mucosa and the colorectal cancer tissues, respectively(P<0.01). The positive rates of EMX2 expression in the colorectal cancer tissues were associated with the clinic stages and lymphatic metastasis. The positive expression rates of β-catenin in the normal colorectal mucosa and the colorectal cancer tissues were 6.7% and 65.5%, respectively. The positive expression rates of Cyclin D1 in the normal colorectal mucosa and the colorectal cancer tissues were 10.0% and 63.6%, respectively. The positive expression rates of β-catenin and Cyclin D1 were associated with the clinic stages, the degree of tumor differentiation and lymphatic metastasis(P<0.05). (2)EMX2 and β-catenin showed negative consistency in colorectal cancer tissues(Kappa=-0.389, P=0.000); The expressions of EMX2 and Cyclin D1 were not obvious(Kappa=-0.161, P=0.054). (3)Kaplan-Meier survival analysis showed that positive EMX2 expression in colorectal cancer tissues was associated with better prognosis(P=0.032). Conclusion　Positive EMX2 expression reduces in colorectal cancer tissues, suggesting that the low expression of EMX2 is associated with clinic stages, lymphatic metastasis and prognosis. EMX2 detection in patients with colorectal cancer may be an indicator of clinical stage and prognosis.]]> 2019/9/30 8:42:00 MENG Yuan, XU Bin 127true ［Abstract］　Objective　To compare the clinical efficacy and safety between rectal administration and oral administration of ibuprofen in treatment of haemodynamically significant patent ductus arteriosus(hsPDA) in infants with very low birth weight. Methods　A total of 58 very low birth weight infants diagnosed with hsPDA were selected from the Neonatal Intensive Care Unit of Dezhou People′s Hospital during June 2016 and December 2018 and were randomly divided into observation group(n=29) and control group(n=29). The observation group received administration of ibuprofen by rectum, and the control group was administered orally. The first dose was 10 mg/kg, 3 doses for a treatment course. A dose of 5 mg/kg was given at 24 h and 48 h after treatment, respectively. The echocardiography re-examination was performed after treatment of 24～48 h. If hsPDA still existed, ibuprofen should be given for the second treatment course. The therapeutic effects and adverse reactions were compared between the two groups. Results　There was no significant difference in the PDA closure rate between the observation group(89.7%) and the control group(93.1%)(P>0.05).There were no significant differences in the incidence rates of pulmonary hemorrhage, intraventricular hemorrhage(>degree Ⅱ), septicaemia, oliguria, pulmonary hypertension, gastrointestinal bleeding and necrotizing enterocolitis between the two groups during ibuprofen treatment(P>0.05).There were 4 cases of gastrointestinal bleeding in the control group and no gastrointestinal bleeding in the observation group. Necrotizing enterocolitis occurred in 5 cases in the observation group and 8 cases in the control group, and 1 case died after intestinal perforation. The incidence of feeding intolerance in the observation group was lower than that in the control group, and the difference between the two groups was statistically significant(P<0.05). After treatment, there were no significant differences in blood urea nitrogen, creatinine, cystatin, total bilirubin, electrolyte, platelet and other indicators between the two groups(P>0.05). There were no statistically significant differences in the length of hospital stay and mortality between the two groups(P>0.05). Before discharge, there were no significant differences in the incidence rates of bronchopulmonary dysplasia and retinopathy of prematurity between the two groups(P>0.05). Conclusion　Rectal administration of ibuprofen is safe, convenient and simple. It is equally effective in treating premature hsPDA as oral administration, and can reduce the occurrence of feeding intolerance, gastrointestinal bleeding and necrotizing enterocolitis.]]> 2019/9/30 8:42:00 YANG Ning, LI Cui 126true ［Abstract］　Objective　To explore the clinical effects of different methods of amniotic membrane transplantation on pterygium. Methods　From February 2016 to March 2017, 150 patients with pterygium were randomly divided into observation group and control group, with 75 eyes in each group. The operation mode of the observation group was pterygium excision+new amniotic membrane transplantation, while that of the control group was pterygium excision+conventional amniotic membrane transplantation. The clinical curative effect and recurrence were observed in the two groups. Results　The corneal epithelium healed completely and the conjunctival incision healed well 10 days after operation in the patients without recurrence after operation in the two groups. After a follow-up of one year, the cure rate was 94.7% and the recurrence rate was 6.7% in the observation group, and 70.7% and 13.3% in the control group, with significant differences between the two groups(P<0.05). Conclusion　Amniotic membrane transplantation can protect the integrity of the conjunctiva and reduce its damage and has a high operative successful rate for the patients with pterygium. The new amniotic membrane transplantation method is easy to operate and can be recommended for clinical application.]]> 2019/9/30 8:42:00 WEI Ying-li, ZHU Hong-yan 125true ［Abstract］　Objective　To investigate the efficacy and safety of nab-paclitaxel combined with S-1(tegafur, gimeracil and oteracil) in treatment of advanced pancreatic cancer. Methods　The clinical data of 60 patients receiving treatment for advanced pancreatic cancer in our hospital during June 2015 and January 2018 were retrospectively analyzed. The patients were divided into observation group and control group according to the method of randam number table. The observation group(n=31) received nab-paclitaxel combined with S-1 and the control group(n=29) was treated with gemcitabine and S-1 for 2 to 6 cycles. The clinical effects and adverse reactions were observed in the two groups. Results　The objective response rate(ORR) of the observation group was higher than that of the control group（41.9% vs 20.7%）, without a significant difference between the two groups（P>0.05）. The disease control rate(DCR) of the observation group was higher than that of the control group（80.6% vs 55.2%）, with a significant difference between the two groups（P<0.05）. The median overall survival time was 9.9 months in the observation group and 8.9 months in the control group, with a significant difference between the two groups（P<0.05）. Conclusion　The combination of nab-paclitaxel and S-1 has good efficacy and safety in the treatment of advanced pancreatic cancer.]]> 2019/9/30 8:42:00 LIU Yan-jie, LU Han-jie 124true ［Abstract］　Objective　To explore the clinical and pathological features, diagnosis, treatment and prognosis of conjunctiva mucosa-associated lymphoid tissue lymphoma(MALToma). Methods　The clinical and pathological data of 11 cases of conjunctiva MALToma were retrospectively analyzed and the patients were followed up. Results　Of the 11 cases, 4 cases were males, 7 females, with age ranging from 23 to 74 years(mean age 45 years). Locations: 10 cases were unilateral, and 1 case was bilateral, and no lymphomas were found in other sites or systems. The pathological morphology showed a large number of dense small to medium sized lymphoid cells and monocytoid B cells were diffusely infiltrated in the mucosal lamina propria, and their nuclei were mildly irregular. The immunophenotyping analysis showed that the infiltrating cells expressed CD20, and did not express CD3, CD5, CD10, CD23 and CyclinD1, with a low proliferation index of ki67(1%～10%) and aberrant expression of CD43 in 5 cases. Five cases were performed Ig gene clonal analysis and the results showed that all cases were monoclonal. Six cases were performed complete resection of the tumors; 2 cases received complete resection of the tumors plus local radiotherapy; 1 case received partial resection of the tumor plus local radiotherapy; 1 case was performed simple biopsy; 1 case received local injection of chemotherapy after biopsy, but the tumor did not regress, and then complete excision and local radiotherapy were performed. The follow-up period ranged from 3 to 122 months, and all the patients survived except for 2 cases who were lost to follow-up. Long-term survival with tumor was observed in the patients receiving simple biopsy of tumor, and no recurrence was observed in the remaining 8 patients. Conclusion　MALToma tends to occur in middle-aged women. The pink mass seen in the conjunctiva is a clinical feature of typical conjunctiva MALToma. Microscopically, there are diffuse infiltration of small to medium sizes of lymphoid cells and monocytes. Tumor cells express B-lymphoid phenotype with low proliferation index, and CD43 is abnormally expressed in some cases. Ig gene cloning analysis is helpful for the diagnosis. Simple complete resection of the tumor or postoperative adjuvant local radiotherapy has good clinical efficacy and good prognosis.]]> 2019/9/30 8:42:00 WEN Zong-hua, ZHOU Xiu-jian, ZHANG Xiao-hong, et al. 123true ［Abstract］　Objective　To analyze the clinical features of medullary thyroid carcinoma and the significance of detecting serum calcitonin and provide the reference for clinical diagnosis and treatment. Methods　The clinical data of 41 patients with medullary thyroid cancer admitted to the First Affiliated Hospital of Chongqing Medical University from January 2011 to September 2016 were retrospectively analyzed. All the patients underwent surgical treatment. The relationship between preoperative serum calcitonin level and tumor size, capsule invasion, lymph node metastasis, distant metastasis and tumor stage was analyzed. Results　The levels of preoperative serum calcitonin were elevated in 35 patients, but there were no statistical significances between the serum calcitonin level and clinical classification, tumor size, single or multiple lesions(P>0.05). However, the patients with tumor envelop invasion had significantly higher levels of preoperative serum calcitonin than those without tumor envelop invasion(P<0.05); the patients with lymph node metastasis had significantly higher levels of preoperative serum calcitonin than those without lymph node metastasis and the patients in stage Ⅲ～Ⅳ had significantly higher levels of preoperative serum calcitonin than those in stage Ⅰ～Ⅱ（P<0.05）. The survival rate of 41 patients with medullary thyroid carcinoma was about 82% within 2～5 years and 78% within 5～8 years after operation, and the overall survival rate was over 78%. Conclusion　The level of calcitonin before surgery is related to whether the tumor capsule is invaded, lymph node metastasis and clinical stage, suggesting that serum calcitonin level can provide reference for preoperative diagnosis, selection of methods, evaluation of prognosis and detection of recurrence and metastasis.]]> 2019/9/2 14:45:32 YANG Luo, ZHANG Yan-li, XUE Guo-jun, et al. 122true ［Abstract］　Objective　To observe the clinical efficacy and safety of compound vitamin combined with low molecular weight heparin(LMWH) and low dose aspirin(LDA) for preeclampsia. Methods　Three hundred and thirty pregnant women with high-risk preeclampsia were collected in Ji′nan Maternal and Child Health Care Hospital from January 2016 to December 2016. The ages of the patients were 19～45 years old with an average of (26.3±4.4)years, and the gestational weeks were 12～16 weeks with an average of (14.3±2.1)weeks. The patients were divided into three groups using the randomized double blind method, including control group(n=110), bigeminy group(treated with LMWH in combination with LDA)(n=110) and trigeminy group(treated with compound vitamin combined with LMWH and LDA)(n=110). The control group received conventional treatment. The bigeminy group was subcutaneously injected with nadroparin calcium 4100 U every time per day until 24 hours before termination and received aspirin(75 mg every time per day) by oral administration until 36 weeks of gestation. The trigeminy group received the same treatment as the bigeminy group plus oral administration of compound vitamin 1 tablet every time per day until delivery. The indicators, including platelet count, activated partial thromboplastin time(APTT), incidence of preeclampsia and adverse pregnancy outcomes(abortion, preterm labor, placental abruption, fetal growth restriction, neonatal asphyxia, perinatal death, and postpartum hemorrhage) were observed and compared among the three groups. Results　The APTT in the bigeminy group and the trigeminy group was significantly longer than that in the control group(P<0.05). The incidence of mild preeclampsia in the bigeminal group and the trigeminy group was significantly lower than that in the control group(P<0.05). There were no statistically significant differences in the incidence rates of severe preclampsia among the three groups(P>0.05). The incidence rates of placental abruption, fetal growth restriction and neonatal asphyxia in the bigeminy group and the trigeminy group were significantly lower than those in the control group(P<0.05). There were no statistically significant differences in the incidence rates of abortion, preterm labor, perinatal death and postpartum hemorrhage among the three groups（P>0.05）. Conclusion　Early treatment of compound vitamin combined with LMWH and LDA can significantly reduce the incidence of preeclampsia in high-risk pregnant women, and decrease the incidence of adverse pregnancy outcomes, but does not increase the risk of postpartum hemorrhage, indicating that compound vitamin combined with LMWH and LDA has better clinical curative effect and high safety.]]> 2019/9/2 14:45:32 LÜ Jun, SHAN Rui-qin, YANG Qiu-hong, et al. 121true ［Abstract］　Objective　To evaluate the preoperative diagnostic value of multi-slice spiral computed tomography(MSCT) in splenic tumors. Methods　The MSCT plain scan and enhanced imaging data of 26 cases of splenic tumors proved by operation and pathology or puncture biopsy were retrospectively analyzed. The image features of MSCT in splenic tumors were investigated. Results　Of the 26 patients, 19 cases were diagnosed by operation and pathology; 7 cases were diagnosed by puncture biopsy. 21 cases(80.77%) were correctly diagnosed by MSCT; 4 cases(15.38%) were misdiagnosed, and 1 case(3.85%) was missed. The sensitivity of MSCT was 81.0% in the diagnosis of splenic tumors. There were 15 cases of benign tumors, including 4 cases of cavernous hemangioma, 3 cases of littoral cell hemangioma, 1 case of capillary hemangioma. Hemangioma often showed progressive enhancement on contrast enhanced scan. For 3 cases of lymphangioma, capsule walls and internal septum of lymphangioma showed mild enhancement on contrast enhanced scan which was the characteristic feature of lymphangioma. 1 case of red pulp type hamartoma showed obvious inhomogeneous enhancement on contrast enhanced scans. 3 cases of splenic cyst(including 2 cases of simple cyst) showed no obvious enhancement in contrast-enhanced scan. 11 cases of malignant tumors and 7 cases of lymphoma showed mild inhomogeneous enhancement on contrast enhanced scans. 4 cases of metastatic tumors showed mild to moderate enhancement on contrast enhanced scan. Conclusion　MSCT findings are of great value in the preoperative diagnosis of splenic tumors.]]> 2019/9/2 14:45:32 SHI Da, ZHANG Xu-chang, ZHANG Xu-hui 120true ［Abstract］　Objective　To observe the efficacy and safety of mirtazapine in treatment of depression in Parkinson′s disease. Methods　A retrospective study was performed on 96 Parkinson′s disease patients with depression in the Department of Neurology, Wuhan Hongqiao Brain Hospital from January 2015 to January 2018. They were divided into control group and observation group according to different medications, with 48 cases in each group. The observation group was treated with mirtazapine and the control group was treated with sertraline. The treatments lasted for 12 weeks in the two groups. The Hamilton Depression Scale(HAMD)score, Activity of Daily Living Scale(ADL) score, Pittsburgh Sleep Quality Index(PSQI) score, and adverse events during treatment period were recorded in both groups. Results　Before treatment, there were no significant differences in age, sex, Parkinson′s disease course, depression course and the scores of HAMD、ADL and PSQI between the two groups(P>0.05). After 12 weeks of treatment, the HAMD and PSQI scores of both groups decreased, and the ADL scores increased. The HAMD and PSQI scores in the observation group were lower than those in the control group, while the ADL scores in the observation group were higher than those in the control group(P<0.05). The observation group had less adverse reactions to gastrointestinal tract than the control group, and the difference was statistically significant(P<0.05). Conclusion　Mirtazapine has a better antidepressant effect than sertraline on the Parkinson′s disease patients with depression, and the adverse reactions of mirtazapine is less than that of sertraline. Mirtazapine can be used as one of the choices for treatment of depression in Parkinson′s disease.]]> 2019/9/2 14:45:32 YUAN Qian, XIAO Jian-hao, LI Xiao-dong, et al. 119true ［Abstract］　Objective　To improve the diagnosis and treatment of pulmonary lymphangioleiomyomatosis(PLAM). Methods　The clinical imaging and pathological data of 5 patients with PLAM treated in the People′s Hospital of Guangxi Zhuang Autonomous Region during July 2007 and July 2018 were respectively analyzed and the related literature was reviewed. Results　All of the 5 patients were female with dyspnea on exertion or cough as the main symptoms, and the results of their chest high-resolution computed tomography（HRCT） scans all showed bilateral diffuse small thin-walled cystic lesions which were consistent with radiological features of PLAM, resulting in a diagnosis of PLAM. Conclusion　PLAM is a rare disease occurring frequently in women. Chest HRCT shows characteristic diffuse small thin-walled cystic lesions in both lungs. Lung biopsy is helpful for diagnosis and PLAM can be treated with sirolimus.]]> 2019/9/2 14:45:32 LUO Ling, Ning Yu, LIU Hang, et al. 118true ［Abstract］　Objective　To observe the curative and immune effects of spleen aminopeptide on refractory mycoplasma pneumoniae pneumonia(RMPP) in children. Methods　Forty-eight children diagnosed with RMPP in the Children′s Hospital of Zhengzhou between January 2016 and January 2018 were collected as the research subjects and were randomly divided into two groups, with 24 cases in each group. The control group was treated with macrolides combined with glucocorticoid and the observation group was treated with spleen aminopeptide plus the same treatment as the control group. The total course of treatment was 1 month in both of the two groups. The clinical effects and the changes of the levels of serum interleukin-2(IL-2), interleukin-6(IL-6) and interleukin-10(IL-10) were compared between the two groups. Results　After treatment, the curative effect of the observation group was significant. The hospitalization time, and the disappearance time of fever, cough and lung rale and chest X-ray shadow in the observation group was significantly shorter than that in the control group(P<0.05). The level of serum IL-6 in the observation group was significantly lower than that in the control group(P<0.05), and the level of IL-2 in the observation group was significantly higher than that in the control group(P<0.05). Conclusion　Spleen aminopeptide can regulate the immune status of the body and promote the recovery of clinical symptoms and signs by regulating the serum levels of IL-2, IL-6 and IL-10 in RMPP children.]]> 2019/8/5 16:14:38 GAO Jun-fang, ZHANG Guang-chao, SUN Xiao-min 117true ［Abstract］　Objective　To explore the correlation between epidermal growth factor receptor(EGFR) mutation status and computed tomography(CT) imaging features and clinical characteristics in lung adenocarcinoma. Methods　The clinical and CT imaging data of 149 lung adenocarcinoma patients who underwent EGFR gene test were collected in our hospital from June 2016 to December 2017. The patients included 80 cases of mutation and 69 cases of wild type. The CT features and clinical characteristics of the EGFR mutation group and the wild type group were compared. Results　Clinical characteristics: the proportion of women with no smoking history and elevated tumor marker carcino-embryonic antigen(CEA) in the EGFR mutation group was higher than that in the EGFR-free group(P<0.05). CT imaging features: the mutation rate of EGFR in the patients with tumor accompanied by burr and pleural effusion was high(P<0.05). Logistic regression analysis showed that gender, tumor marker CEA and spicule sign of CT imaging had predictive value for EGFR mutation in lung adenocarcinoma. Conclusion　Univariate analysis results suggest that EGFR mutation status of lung adenocarcinoma is related to the patients′ gender, smoking history, tumor marker CEA, burr sign and pleural effusion. Logistic regression models suggest that female, elevated CEA and burr signs are risk factors of EGFR mutation in patients with lung adenocarcinoma.]]> 2019/8/5 16:14:38 DING Jia-jia, SU Xiang-yu, WANG Cai-lian, et al. 116true ［Abstract］　Objective　To analyze the curative effect of laparoscopic intersphincterectomy without auxiliary incision on ultra-low rectal cancer. Methods　Thirty-seven patients with rectal cancer admitted to our hospital from June 2016 to June 2018 were divided into the laparoscopy group and the laparotomy group according to different operation methods, in which 20 patients underwent laparoscopic surgery(the laparoscopy group) while 17 patients underwent laparotomy(the laparotomy group). The laparoscopy group was treated with laparoscopic intersphincterectomy without auxiliary incision, and the laparotomy group received conventional open surgery. The operation time, intraoperative blood loss, exhaust time, first feed time and hospital stay after the operation, and the number of lymph node removed after operation were compared between the two groups. Results　The operation time of the laparoscopy group was longer than that of the laparotomy group(P<0.05), the intraoperative blood loss, exhaust time, first feed time and hospital stay after operation in the laparoscopy group were less or shorter than those in the laparotomy group(P<0.05). There was no significant difference in the number of lymph nodes excised between the two groups(P>0.05). The incidence of surgical complications in the laparoscopy group and the laparotomy group was 5.00% and 29.41% respectively, and the difference was statistically significant between the two groups（P<0.05）. Conclusion　Laparoscopic intersphincterectomy without auxiliary incision is safe and feasible for ultra-low rectal cancer, and the operation has minimally invasive advantages of less bleeding and fast recovery, and its short-term efficacy is positive. There is no significant difference in the number of resected lymph nodes between laparoscopy and laparotomy.]]> 2019/8/5 16:14:38 FEI Qiang, HUANG You-ling, LU Wen-xian 115true ［Abstract］　Objective　To explore the significance of procalcitonin(PCT), C-reactive protein(CRP) and platelet count(PLT) in early identification of pathogenic bacteria of late-onset sepsis in premature infants. Methods　Through retrospective analysis, the differences of PCT, CRP and PLT levels of 45 premature infants with late-onset sepsis in our department were compared among different pathogenic bacteria infection groups which were divided into Gram-negative bacteria group(n=26), Gram-positive bacteria group(n=7), and fungi group(n=12). Twenty non-infectious premature infants hospitalized in the same period were taken as the control group, and the distribution characteristics of pathogenic bacteria were studied. Results　The level of PCT in the Gram-negative bacteria group was significantly higher than that in the other three groups(P<0.05); the level of CRP was the highest, and the level of PLT was the lowest in the fungi group among the four groups, with statistically significant differences(P<0.05). When the level of PCT was higher than 9.7 ng/ml, it was more likely to be infected by Gram-negative bacteria, and the sensitivity and specificity were 100.0% and 92.3% respectively. When the level of CRP was higher than 20.8 mg/dL, it was more likely to be infected by fungi, and the sensitivity and specificity were 91.7% and 79.2% respectively. When the level of PLT was lower than 82×10⁹/L, it was more likely to be infected by fungi, and the sensitivity and specificity were 94.3% and 66.6% respectively(P=0.000). Gram-negative bacteria accounted for 57.8% of the pathogenic bacteria which was mainly Klebsiella pneumoniae; Gram-positive bacteria accounted for 15.6% and fungi accounted for 26.7%. Conclusion　The levels of PCT, CRP and PLT have important reference significance for early identification of pathogenic bacteria of late-onset sepsis in premature infants. Klebsiella pneumoniae and Candida are the main pathogens of late-onset sepsis in premature infants, which provides a basis for early and rational selection of antibiotics in clinics.]]> 2019/8/5 16:14:38 ZENG Ya-li, HUANG Peng, DIAO Shi-guang, et al. 114true ［Abstract］　Objective　To study the diagnostic value of brachial-ankle pulse wave velocity(baPWV) in coronary heart disease(CHD). Methods　One hundred and ninety patients from our hospital were included in this study and the patients were divided into CHD group(n=106) and control group(n=84) according to the result of the coronary angiography(CAG). The CHD group was divided into three sub-groups: single-vessel disease group, double-vessel disease group and severe disease group. The levels of baPWV were compared among the CHD sub-groups and the control group. The outcomes of CAG were taken as the gold standard to evaluate, the efficacy of baPWV in the screening of CHD by drawing ROC curve. Results　The level of baPWV in the CHD group was significantly higher than that in the control group(P<0.05). The differences in the baPWV levels between any two groups among the single-vessel disease group(1 620.13±94.47)cm/s, the double-vessel disease group(1 732.97±84.26)cm/s and the severe disease group（1 913.20±180.75）cm/s were significant(P<0.05）. The best cut-off point for screening of CHD was 1 535 cm/s, with the sensitivity being 83.4%, the specificity being 88.3% and Youden′s index being 0.730 from the characteristic of ROC curve. Conclusion　The change of baPWV can screen CHD and predict the severity of coronary stenosis.]]> 2019/8/5 16:14:38 ZHANG Rong-cheng 113true ［Abstract］　Objective　To evaluate the value of coronary computed tomography angiography(CCTA) in diagnosis of in-stent restenosis(ISR) after coronary stent implantation, and to analyze the related factors of ISR. Methods　One hundred and six patients who had been performed coronary stenting were examined by CCTA and coronary angiography(CAG) for evaluating ISR. The diagnostic results of CAG were taken as the golden standard to evaluate the sensitivity and specificity of CCTA in the diagnosis of ISR after coronary stent implantation and to analyze whether the restenosis was related to the position, diameter, length and type of stents. Results　(1)The diagnostic specificity, sensitivity, negative predictive value and positive predictive value of 174 stent restenosis in 106 patients with CCTA were 97.3%, 91.7%, 98.6% and 84.6%, respectively. The diagnostic consistency with CAG was high（Kappa=0.860）. (2)ISR was related to the diameter of stents and whether stenosis was located at a vascular bifurcation, but was not related to the length of stents, the type of stents and the segment of the coronary artery in which the stents were located. Conclusion　The diagnostic results of CCTA for restenosis are in good agreement with those of CAG. In addition, the formation of stent restenosis is related to stent diameter and stenotic lesion at the vascular bifurcation.]]> 2019/7/1 16:32:50 YAN Li, CHENG Qi 112true ［Abstract］　Objective　To investigate the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR), lymphocyte-to-monocyte ratio(LMR) and postoperative pathological findings of vascular tumor thrombi in rectal cancer patients. Methods　A retrospective analysis of the preoperative blood test and clinicopathological data of 321 patients with rectal cancer who were initially admitted to the Department of General Surgery of the Second Affiliated Hospital of Zhengzhou University and underwent radical surgery from January 2014 to December 2017 was performed. According to the postoperative pathological data, the patients were divided into lymphovascular invasion group(n=84) and non-lymphovascular invasion group(n=237). The correlation between vascular tumor thrombus and preoperative NLR, LMR and clinical pathological data was analyzed. Results　The results of univariate analysis showed that T stage, N stage, differentiation degree, preoperative NLR and LMR were significantly correlated with rectal cancer vascular tumor thrombi(P<0.05). Multivariate analysis showed that N₁+N₂ in N stage, preoperative high NLR and low LMR were the independent risk factors for lymphovascular invasion in the patients with rectal cancer(P<0.05). Conclusion　The levels of preoperative NLR and LMR can help the surgeons to determine whether there is lymphovascular invasion in rectal cancer patients, and help to determine the tumor stages before surgery. Preoperative high NLR and low LMR suggest an increased chance of lymphovascular invasion in rectal cancer patients.]]> 2019/7/1 16:32:50 KANG Qi, NIU Yue-ping, GAO Jian, et al. 111true ［Abstract］　Objective　To compare the clinical effects and safety of open surgery and laparoscopic surgery in treatment of benign adrenal tumors more than 6 cm in diameter. Methods　One hundred and fifty patients with benign adrenal tumors more than 6 cm in diameter were chosen and randomly divided into the open surgery group(n=75, treated with open surgery) and the laparoscopic surgery group(n=75, treated with laparoscopy). The levels of clinical indexes, the ICU transfer incidence and the complication rate were compared the two groups during and after operation. Results　The levels of clinical index of the laparoscopic surgery group were better than those of the open surgery group during and after operation（P<0.05）. There was no significant difference in the ICU transfer incidence between the two groups（P>0.05）. The complication rate of the laparoscopic surgery group was significantly lower than that of the open surgery group after operation（P<0.05）. There was no significant difference in the complication rate during operation between the two groups（P>0.05）. Conclusion　Compared with open surgery, laparoscopic surgery has some advantages in treatment of benign adrenal tumors more than 6 cm in diameter including simple operation, minimal invasion and faster recovery after operation and can efficiently reduce the complication risks.]]> 2019/7/1 16:32:50 ZHANG Han, WEI Peng-tao, LÜ Wen-wei, et al. 110true ［Abstract］　Objective　To study the edge suitability of the complete denture repair of three types of alveolar ridge patients with open or closed-mouth silicone rubber impression. Methods　The edentulous patients were chosen in our hospital between January 2016 and January 2018 and were performed complete denture repair, and were classified according to Atwood taxonomy, including 18 patients with level 2 alveolar ridge, 20 patients with level 3 alveolar ridge and 12 patients with level 4 alveolar ridge. Each of the three types of alveolar ridge was divided into observation group(n=25) and control group(n=25). The observation group was treated with complete denture repair and closed silicone rubber impression, while the control group was treated with complete denture repair and open type silicone rubber impression. Within one month after repairment, the number of the patients who visited the doctors due to inappropriate denture edges, the number of grinding areas and the number of times each area had been ground were statistically analyzed. Results　 Within one month after repairment, the number of times each area had been ground in the three types of alveolar ridge in the observation group was significantly less than that in the control group(P<0.05), especially in the level 4 alveolar ridge(P<0.01). In the observation group, the number of grinding areas in the level 3 and level 4 alveolar ridge was significantly less than that in the control group(P<0.05), and there was no significant difference in the number of grinding areas in the level 2 alveolar ridge between the observation group and the control group(P>0.05). In the mandibular molar area, the number of grinding is the most, followed by the maxillary molar area. Conclusion　The edge suitability of the complete denture by the closed-mouth silicone rubber impression is obviously higher than that by the open silicone rubber impression, and the effect is more obvious when the condition of alveolar ridge is worse.]]> 2019/7/1 16:32:50 PENG Yan 109true ［Abstract］　Objective　To compare the efficacy of phacoemulsification crystal extraction combined with goniosynechialysis and compound trabeculectomy on treating patients with primary angle-closure glaucoma complicated with cataract. Methods　Eighty-eight patients(88 eyes) of primary angle-closure glaucoma complicated with cataract diagnosed in our hospital from July 2014 to August 2018. They were randomly divided into two groups, with 44 patients(44 eyes) in the observation group and the rest(44 patients, 44 eyes) in the control group. The observation group was treated with phacoemulsification crystal extraction combined with goniosynechialysis, and the control group was treated with compound trabeculectomy. Visual acuity, intraocular pressure, anterior chamber depth and complications were compared between the two groups before and after surgery(1 day, 7 days and 1 month). Results　The intraocular pressure of the two groups at 1 day, 7 days and 1 month after surgery was significantly lower than that before surgery(P<0.05), and could be maintained within the normal range with time going on. The intraocular pressure of the observation group was lower than that of the control group 7 days and 1 month after surgery, and the difference was statistically significant(P<0.05). The visual acuity of the patients in the observation group was significantly improved 1 day, 7 days and 1 month after surgery compared with that before surgery(P<0.05). The visual acuity of the patients in the control group did not change significantly 1 day after surgery, but improved significantly 7 days and 1 month after surgery. At the same time point of 1 day and 7 days after surgery, the difference in visual acuity between the observation group and the control group was statistically significant(P<0.05), but there was no statistically significant difference 1 month after surgery(P>0.05). One month after surgery, the anterior chamber depth in the observation group was significantly higher than that before surgery, and the difference was statistically significant(P<0.05). There was no significant difference between preoperative and anterior chamber depth one month after operation in the control group(P>0.05). The incidence of complications in the observation group(15.91%) was lower than that in the control group(34.09%) (P<0.05). Conclusion　The patients with primary angle-closure glaucoma and cataract receiving phacoemulsification crystal extraction combined with goniosynechialysis and compound trabeculectomy can achieve the goal of significantly reducing intraocular pressure and improving eyesight, but the phacoemulsification crystal extraction combined with goniosynechialysis postoperative anterior chamber depth deepening has higher safety and less complications, and is worth popularizing in clinic.]]> 2019/5/31 17:17:33 ZHONG Shan, ZENG Si-ming 108true ［Abstract］　Objective　To investigate the correlation between the serum levels of β-amyloid 1-42(Aβ1-42) and polymorphisms of N5, N10-methylenetetrahydrofolate reductase(MTHFR) gene in patients with Parkinson′s disease(PD). Methods　The polymorphisms of MTHFRC677T gene were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique in 50 PD patients and 50 normal controls, and their serum levels of Aβ1-42 were detected by Enzyme-linked Immunosorbent Assay(ELISA) method. Results　The frequency of TT type of MTHFR gene in PD patients was 32.0%; the frequency of CT type was 52.0% and the frequency of CC type was 16.0%. The frequencies of TT type, CT type and CC type in the control group were 12.0%, 56.0% and 32.0% respectively. In PD group, the frequency of T allele was 60.0% and the frequency of C allele was 40.0%. In the control group, the frequency of T allele was 42.0% and the frequency of C allele was 58.0%. The serum level of Aβ1-42 in the patients with TT type of MTHFR gene in PD group was significantly lower than that in the patients with other two types(F=4.831, P=0.012), and the serum level of Aβ1-42 in CT type was significantly lower than that in CC type(P<0.05). Conclusion　The MTHFR C677T gene mutations may be significantly associated with Aβ1-42 levels in patients with PD and the homozygous mutation in MTHFR gene may be an important genetic factor of lower Aβ1-42.]]> 2019/5/31 17:17:33 WU Qi, HAN Dong-yang, ZHOU Sha-sha, et al. 107true ［Abstract］　Objective　To observe the clinical effect of intravenous fast- tracking anesthesia using target-controlled infusion(TCI) with propofol and remifentanil combined with mivacurium on patients undergoing suspension laryngoscope surgery. Methods　Sixty adult patients（ASAⅠ～Ⅱ） were performed selective polypectomy of vocal cords and were randomly divided into observation group and control group, with 30 cases in each group. The patients in the observation group were anesthetized with target-controlled intravenous infusion of propofol, remifentanil and mivacurium, and the patients in the control group were anesthetized with propofol, sufentanil and rocuronium. The mean arterial pressure（MAP）, heart rate (HR), operation time, anesthesia time, extubation time, residence time in PACU and Riker sedation-agitation scale scores in PACU were monitored in both of the two groups before anesthesia（T₀） and intubation(T₁), and after endotracheal intubation(T₂) and placement of suspension laryngoscopy(T₃) and removal of laryngoscope(T₄) and leaving PACU(T₅). Results　Compared with those of T₀ in the same group, the MAP and HR of T₁ and T₂ were significantly decreased(P<0.05). Compared with those of T₁, T₂ and T₄ in the same group, the MAP and HR of T₃ were significantly elevated(P<0.05). There were no statistically significant differences in the levels of MAP and HR between the two groups at different time points(P>0.05). The extubation time and residence time in PACU of the observation group were significantly earlier than those of the control group(P<0.05). There were no statistically significant differences in the anesthesia time and the operation time between the two groups(P>0.05). Conclusion　Fast-tracking anesthesia of target-controlled infusion with propofol, remifentanil and mivacurium can maintain relatively hemodynamic stability and shorten the postoperative awakening period in the patients undergoing polypectomy of vocal cords by suspension laryngoscope.]]> 2019/5/31 17:17:33 XIE Ran, WANG Hao, JI Fan-ceng, et al. 106true ［Abstract］　Objective　To investigate the clinica significance of grade Ⅳ dyspnea for further clinical staging, which caused by acute laryngeal obstruction, and investigate the clinical indications for the treatment of emergency cricothyroidotomy. Methods　A retrospective analysis was performed on 30 patients who underwent emergency airway surgery for grade Ⅳ dyspnea due to laryngeal obstruction from December 1997 to December 2017, and a 3-month follow-up was conducted. Results　All the 30 patients were treated successfully, and no treatment failed. During the follow-up, 1 case was found to have sequelae, while the rest recovered well. No serious complications were found during the follow-up. Conclusion　Further staging grade Ⅳ dyspnea of acute laryngeal obstruction is of great clinical significance. Therefore, emergency cricothyroidotomy is of great significance for the rescue of acute laryngeal obstruction.]]> 2019/5/31 17:17:33 ZHU Ren-liang, LIU Chun-lin, XIE Wei, et al. 105true ［Abstract］　Objective　To explore the clinical effect of bone graft in vertebral pedicle vertebra after fracture reduction on patients with thoracolumbar fractures. Methods　The clinical data of 60 patients with thoracolumbar fractures admitted to our hospital from March 2016 to March 2017 were retrospectively analyzed. All the patients were treated with pedicle intravertebral bone grafting and were followed up for 1 year. The vertebral height ratio, bone graft and relative area of bone defect were analyzed. Results　Immediately after surgery, and 1 year after surgery, the height ratio of vertebral anterior edge and the height ratio of vertebral posterior edge were all higher than those before surgery, and the differences were statistically significant(P<0.05). There were no significant differencesly in the height ratio of vertebral anterior edge and the height ratio of vertebral posterior edge between immediate and 1 year after surgery(P>0.05). There was no significant difference between the loss of anterior edge height ratio and the loss of posterior edge height ratio(P>0.05). The bone graft block and the relative area of bone defect six months after operation were all less than those immediately after operation and the differences were statistically significant(P<0.05). The bone graft block and the relative area of bone defect of the patients one year after surgery were lower than those of the patients six months after surgery and immediately after surgery, and the differences were statistically significant(P<0.05). Conclusion　Bone grafting in vertebral pedicle can reduce the loss of correction, but can not restore the vertebral space.]]> 2019/5/31 17:17:33 LIU Jie 104true ［Abstract］　Objective　To explore the application value of vitamin D supplement in treatment of childhood asthma. Methods　One hundred and thirty-six children with acute asthma were randomly divided into observation group(n=68) and control group(n=68). The children in both groups were given routine treatment of asthma, while the children in the observation group were given vitamin D drops 800 IU/d orally on the basis of the routine treatment. After 12 weeks of treatment, the Children′s Asthma Control Test(C-ACT) was used to evaluate asthma control in both groups. The percentages of forced expiratory volume in the first second(FEV1%) and forced vital capacity(FVC%) before and 12 weeks after treatment were compared between the two groups and the changes of serum 25-(OH)D, total IgE and eosinophil cationic protein(ECP) levels were also compared. Results　After 12 weeks of treatment, the asthma control rate was 88.2% in the observation group and 75.0% in the control group(P<0.05), but there were no significant differences in the improvements of FEV1% and FVC% between the two groups(P>0.05). The levels of serum total IgE and ECP in both groups after treatment were significantly lower than those before treatment(P<0.01), but those in the observation group were significantly lower than those in the control group(P<0.05). No obvious drug-related adverse reactions were found in the two groups. Conclusion　Short-term and low-dose vitamin D supplement may reduce the serum IgE and ECP levels in asthmatic children to some extent. It is beneficial to improve the clinical control rate and has good safety.]]> 2019/4/30 17:22:17 HUANG Li-juan, DONG De-xing 103true ［Abstract］　Objective　To analyze clinical efficacy of percutaneous kyphoplasty(PKP) in treatment of osteoporotic vertebral compression fractures(OVCF) in the elderly. Methods　The clinical data of 216 elderly patients with OVCF treated with PKP from June 2015 to January 2018 in our hospital were retrospectively analyzed. All the patients were treated with PKP, and the surgical effects were evaluated by evaluating the preoperative and postoperative Cobb Angle, vertebral body loss height, visual simulation score(VAS), and the incidence of postoperative lateral leakage. Results　After a follow-up of (15±9)months, the patients′ pain was significantly reduced or disappeared, the preoperative Cobb Angle was (30.1±3.8) °. The preoprative vertebral height loss was (12.1±1.0)mm, and the preoprative VAS was (8.58±1.22)points. The Cobb Angle was (15.5±3.8) °, and the vertebral body height loss was (3.2±0.8)mm, and the VAS was (2.6±0.7)points at the last follow-up point. The postoperative sliding sideways occurred in 13 cases among whom 10 cases had no obvious symptoms, 3 cases had symptoms of nerve stimulation but they were improve after symptomatic treatment and the incidence of sliding sideways was 6.0%. Conclusion　PKP is an effective method for the treatment of senile OVCF with short operative time, minimally invasive, effective vertebral height reconstruction and pain relief, which is worthy of clinical promotion.]]> 2019/4/30 17:22:17 GU Yan-chao, HU Sheng-li, XIE Wei, et al. 102true ［Abstract］　Objective　To explore the relationship between serum levels of 25-hydroxyvitamin D［25(OH)D］ and lower-extremity arterial disease(LEAD) in type 2 diabetes mellitus(T2DM) patients and the early influencing factors of LEAD. Methods　Two hundred and twenty-six cases of T2DM were collected as diabetic group, including DM1 group(82 new diagnostic T2DM patients without complications) and DM2 group(144 diabetic patients with LEAD), and 66 cases of healthy subjects were collected as normal control group. The serum levels of 25(OH)D, tumor necrosis factor-α(TNF-α) and retinol-binding protein 4(RBP4) were determined by enzyme-linked immunosorbent assay. Results　The levels of 25(OH)D in the DM2 group were significantly lower than those in the control group［(12.63±7.83)ng/ml vs (24.77±5.92)ng/ml, P<0.01］. The levels of 25(OH)D in the DM1 group were slightly lower than those in the control group. The levels of TNF-α and RBP4 in the DM2 group were significantly higher than those in the control group［TNF-α:（2.67±0.75） pg/ml vs（ 0.43±0.22 ）pg/ml; RBP4:（39.00±2.10）μg/ml vs （14.82±1.84）μg/ml, P<0.01］. There were significantly negative correlations between the levels of 25(OH)D and TNF-α（r=-0.267, P=0.045） and RBP4（r=-0.538, P=0.015）. Conclusion　Low level of 25(OH)D is significantly associated with the occurrence of T2DM complicated with LEAD, and the factors that contribute to LEAD include inflammatory cytokines and the damadge of vascular endothecium.]]> 2019/4/30 17:22:17 JI Zhi-shang, LIU Xiu-ying 101true ［Abstract］　Objective　To investigate the effects of impaired glucose tolerance on urinary albumin to creatinine ratio(ACR) and left ventricular mass index(LVMI) in hypertensive patients. Methods　A retrospective analysis of 184 patients with grade 2 or above of essential hypertension from December 2016 to February 2018 was performed. The duration of hypertension was less than 10 years. All the selected subjects underwent simplified glucose tolerance test, and fasting blood glucose(FPG) and OGTT 2-hour blood glucose(2h PG) were recorded in each patient. The patients who were diagnosed with fasting blood glucose and 2-hour blood glucose abnormality in the OGTT test according to the criteria of National Clinical Laboratory Procedures were divided into two groups: the control group ［with normal blood glucose(NGT), n=91］ and the impaired glucose tolerance(IGT) group(n=93). The general clinical data such as height, weight, body mass index(BMI), gender, age, course of hypertension, blood pressure, blood lipids, and creatinine were recorded. ACR and cardiac color Doppler ultrasonography were performed on all the patients. Interventricular septal thickness(IVST), left ventricular posterior wall thickness(PWT), left ventricular ejection fraction(LVEF) and left ventricular internal diameter at end-disatole(LVIDd) were recorded. The effects of impaired glucose tolerance on ACR and LVMI were studied. Results　There were no significant differences in the course of hypertension, age, gender, BMI, diastolic blood pressure, HDL-C, LDL-C, triglyceride(TG) and FPG between the two groups(P>0.05). The systolic blood pressure, ACR, TC, creatinine and ventricular septal thickness in the IGT group were significantly higher than those in the NGT group（P<0.05）. The ejection fraction of the IGT group was significantly lower than that of the NGT group(P<0.05). The mean rates of ACR and LVMI, and the MAU positive rate and left ventricular hypertrophy in the IGT group were significantly higher than those in the NGT group(P<0.01). The 2h PG level was positively correlated with ACR(r=0.67, P<0.01) and positively correlated with LVMI(r=0.45, P<0.01). Logistic regression analysis showed that 2h PG(OR=1.449, 95% CI: 1.006～2.089) and ventricular septal thickness(OR=2.317, 95% CI: 1.539～3.490) were the risk factors of left ventricular hypertrophy(P<0.05). Conclusion　The target organ damages such as microalbuminuria and left ventricular hypertrophy have been observed in the stage of hypertension complicated with impaired glucose tolerance.]]> 2019/4/30 17:22:17 CHEN Su-fen, ZHAO Yu-lan, HUANG Ya-ping 100true ［Abstract］　Objective　To investigate the clinical application effect of chimeric perforator flap based on descending branch of lateral circumflex femoral artery. Methods　Twenty-one cases of soft tissue defects including 12 cases of calf soft tissue defects and 9 cases of tibial or calcaneal osteomyelitis were selected, whose area of soft tissue defects were 4 cm×4 cm～6 cm×8 cm. All the patients were repaired by free transplantation of chimeric perforator flap based on descending branch of lateral circumflex femoral artery. Results　All the flaps of the 21 patients survived after follow-up of 8 to 26 months, with satisfactory color and texture of the flaps, no recurrence of osteomyelitis and non-stress fracture, and linear scars left in the donor site of the flaps. The AOFAS scores of the affected limbs were 82 to 92 points, with an average of (87.3±1.9) points at the last follow-up. Conclusion　Chimeric perforator flap based on descending branch of lateral circumflex femoral artery is an effective method for the treatment of soft tissue defects of legs.]]> 2019/4/30 17:22:17 WANG Jiu-qing, ZHANG Xian, GUO Qing-gong, et al. 99true ［Abstract］　Objective　To investigate the effect of tizanidine on patients with limb spasm after stroke. Methods　Sixty-three patients with spasm of limbs after stroke received conventional rehabilitation treatment and were randomly divided into tizanidine treatment group(n=32) and baclofen control group(n=31) by rondom number table method. The degrees of upper and lower limb spasm, motor function and activity of daily living were evaluated using the modified Ashworth score, clinic spasticity index, Fugl-Meyer assessment(FMA) and improved Bathel index respectively before and 12 weeks after treatment. Results　After treatment of 12 weeks, the symptoms of limb spasm were improved significantly in both of the two groups with decreased muscle tone, improved motor function of the affected limbs and improved activity of daily living, but there were no significant differences between the two groups(P>0.05). The incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group(P<0.05). Conclusion　Tizanidine has a good effect on the treatment of limb spasm after stroke, and the clinical adverse reactions are slighter, and the patients have a good tolerance.]]> 2019/4/1 16:03:53 YAN Gui-fang, YIN Yu, ZHAO Zhen-biao, et al. 98true ［Abstract］　Objective　To systematically evaluate the efficacy and safety of luseogliflozin in treatment of type 2 diabetes mellitus(T2DM). Methods　The randomized controlled trials(RCTs) of luseogliflozin for T2DM were searched from Cochrane Library, PubMed, EMBase, CBM, CNKI, Wanfang and VIP databases using a computer. The data were extracted and the quality of the included studies was assessed. RevMan5.3 statistical software was used for Meta-analysis. Results　A total of 764 cases in 5 RCTs were included, which were from English databases. Compared with those in the placebo group, HbA1c ［WMD=-0.94, 95%CI(-1.02, -0.87), P<0.01］ and fasting plasma glucose ［WMD=-33.09, 95%CI(-35.93, -30.25), P<0.01］ in the luseogliflozin group were decreased; The incidence of adverse reactions ［RR=1.92, 95%CI(1.30, 2.83), P<0.01］ and frequency of urinary frequency ［RR=2.41, 95%CI(1.09, 5.37), P=0.03］ in the luseogliflozin group were increased. There were no significant differences in the incidence rates of adverse events ［RR=1.01, 95%CI(0.88, 1.15), P=0.91］, hypoglycemia ［RR=1.36, 95%CI(0.76, 2.42), P=0.30］, urinary tract infections ［RR=2.50, 95%CI(0.30, 21.11), P=0.40］, reproductive system infections ［RR=1.72, 95%CI(0.50, 5.89), P=0.39］,abnormal renal function［RR=1.18, 95%CI(0.69, 2.02), P=0.53］ and volume reduction related adverse reactions［RR=1.34, 95%CI(0.47, 3.80), P=0.59］ between the two groups. Conclusion　In different treatment cycles of T2DM, luseogliflozin can effectively improve HbA1c and fasting plasma glucose, but leads to no serious adverse events and special adverse reactions. The adverse reactions are common, mild and tolerable, and the medication is safe.]]> 2019/4/1 16:03:53 XIONG Chang, HAN Yi, REN Xiao-fen, et al. 97true ［Abstract］　Objective　To investigate the relationship of preoperative mean platelet volume（MPV） with early rectal carcinoma recurrence. Methods　The study consisted of 50 patients with a diagnosis of early rectal carcinoma and the patients were divided into recurrence-free group(n=41) and recurrence group(n=9). The perioperative clinical data of the patients were collected and were statistically analyzed. Results　The level of preoperative MPV in the recurrence group［（12.46±1.95）fL］ was higher than that in the recurrence-free group［(9.85±1.34)fL］, P<0.05. Logistic regression models revealed that MPV significantly associated with recurrence and metastasis and preoperative MPV（OR=3.726, 95%CI=1.216～11.413) and CA19-9(OR=0.010, 95%CI=0.000～0.449） were independent risk factors for postoperative recurrence of early rectal carcinoma. Conclusion　The level of preoperative MPV is associated with early rectal carcinoma, and MPV may be used for predicting the recurrence of early rectal carcinoma after operation.]]> 2019/4/1 16:03:54 ZHANG Qi, HAN Bin 96true ［Abstract］　Objective　To study the mutation of RUNX2 gene in a neonate with cleidocranial dysplasia(CCD). Methods　The clinical and imaging examinations of the neonate with CCD were performed after physical examination, and the diagnosis was confirmed as clavicular dysplasia of the skull. The genomic DNA of the whole blood was extracted and sent to the third party（KingMed Diagnostics） for detection, and the genotype of RUNX2 was detected by high-throughput genome sequencing. Results　The mutant type of RUNX2 gene in the patient was c.201dupG P.(Gln68fs). Conclusion　A pathogenic mutation of RUNX2 is found successfully, which supplements the gene mutation database of CCD.]]> 2019/4/1 16:03:54 LI Rui, KANG Wen-qing, JIN Juan, et al. 95true ［Abstract］　Objective　To study the postoperative curative effects and complications between alum hemorrhoid injection and hemorrhoid ligation in treatment of different stages of hemorrhoids. Methods　Two hundred and four patients with different stages of hemorrhoids were selected as the study subjects in our hospital from May 2017 to November 2017. The patients were divided into observation group and control group according to different treatment methods, with 102 cases in each groups. The observation group received hemorrhoid injection while the control group received automatic hemorrhoid ligation. The clinical effects, the operation time, the time of hospitalization, the postoperative bleeding, the complications such as pain and swelling and safety evaluation were compared between the two groups. Results　There was no significant difference in the total effective rate between the observation group(94.12%) and the control group(93.14%)(P>0.05). The time of operation in the observation group was significantly shorter than that in the control group（P<0.05）. The amount of bleeding during operation in the observation group was significantly larger than that in control group（P<0.05). The hospitalization time in the observation group was significantly shorter than that in the control group(P<0.05). The incidence of postoperative complications in the observation group was significantly lower than that in the control group（P<0.05）. Conclusion　The alum hemorrhoid injection has better curative effects on hemorrhoids than hemorrhoid ligation in the treatment of different stages of hemorrhoids, and it shows advantages in reducing the sense of fall bilge feeling and anal edema and shortens the time of hospitalization and reduces the incidence of postoperative complications and enhances recovery after treatment. It is suitable for basic-level hospitals.]]> 2019/3/4 16:47:08 HAN Bin-ze, YANG Tie-jun, HE Jin, et al. 94true ［Abstract］　Objective　To investigate the diagnostic value of positron emission tomography-computed tomography（PET-CT） combined with serum tumor markers in lung cancer. Methods　The data of 56 hospitalized patients with lung cancer in our hospital from January 2016 to March 2018 were retrospectively analyzed. The accuracy, specificity and sensitivity of PET-CT, serum tumor markers and PET-CT combined with serum tumor markers were analyzed for the diagnosis of lung cancer. Results　The accuracy, specificity and sensitivity were 76.79%, 69.23% and 79.07% in PET-CT method, and 69.64%, 53.85% and 74.42% in serum tumor markers detection method, 85.71%, 53.85% and 95.35% in PET-CT combined with serum tumor markers detection method. The combined examination method can improve the diagnostic accuracy and sensitivity of lung cancer, with significant differences among the three methods(P<0.05). Conclusion　PET-CT combined with serum tumor markers detection can improve the diagnostic accuracy and sensitivity of lung cancer, and is suitable for clinical application.]]> 2019/3/4 16:47:08 GAO Feng, QIAN Wen-xia 93true ［Abstract］　Objective　To explore the application value of color ultrasound-guided percutaneous transhepatic gallbladder drainage(PTGBD) for severe cholecystitis in elderly patients. Methods　The clinical data of 64 elderly patients with severe cholecystitis in our hospital from January 2015 to June 2018 were analyzed retrospectively. Of the 64 elderly patients, 34 cases were treated with PTGBD under color Doppler ultrasound guidance on the basis of medical treatment(PTGBD group), and 30 cases were given conservative treatment(control group). The changes of body temperature, abdominal pain score and white blood cell count, erythrocyte sedimentation rate, hypersensitive C-reactive protein, procalcitonin, gamma-glutamyl transpeptidase, total bilirubin, direct bilirubin, hospitalization time and hospitalization costs were statistically analyzed and compared before and after PTGBD treatment between the two groups. Results　Compared with those in the control group, the patients in PTGBD group had shorter hospitalization time and less hospitalization costs（P<0.05）. The body temperature of the patients in PTGBD group dropped to normal within 72 hours after operation, and the abdominal pain improved significantly. Leukocyte count, erythrocyte sedimentation rate, hypersensitive C-reactive protein, procalcitonin, gamma-glutamyl transpeptidase, total bilirubin, direct bilirubin, and international standardized ratio in the patients in PTGBD group after treatment were reduced significantly within one week and the differences were statistically significant compared with those before treatment(P<0.05). Conclusion　Color ultrasound-guided PTGBD has the advantages of minimal wounding. It can quickly reduce the pressure inside the gallbladder and prevent sepsis and has a high application value for elderly patients with severe cholecystitis who have surgery contraindication.]]> 2019/3/4 16:47:08 LI Huan, LONG Hui, HE Fei 92true ［Abstract］　Objective　To analyze the clinical features and safety of submucosal tumors(SMTs) in the upper gastrointestinal tract. Methods　Two hundred and sixty-four patients with upper gastrointestinal SMTs were selected as the study subjects in our hospital from February 2012 to February 2017, endoscopic treatment of SMTs in the upper gastrointestinal tract was performed. The specimens were resected for routine pathological examination and immunohistochemical analysis. The sizes, distributions and depth of lesions in all kinds of submucosal masses were investigated. All the patients were followed up for 12 months after surgery. Results　Of the 264 patients included, 65.9% had submucosal tumors, 33.0% had submucosal tumors, and 1.1% had duodenal submucosal tumors. Among all the tumors, 72.3% were leiomyomas, 12.1% were stromal tumors, 5.3% were lipomas, 4.6% were ectopic pancreas, 1.5% were schwannomas, 1.1% were cysts, 1.1% were neuroendocrine tumors, 1.1% were varicose vein and 0.8% were granulosa cell. No recurrence or complications were found. Conclusion　The SMTs of upper gastrointestinal tract are mainly composed of benign masses which are most commonly seen in the esophagus, followed by the stomach and the least duodenum. The SMTs of the esophagus are the most common in leiomyoma, and the stomach is the most common site for leiomyoma and stromal tumors. The tumors with diameter is less than or equal to 4 cm, such as leiomyoma, stromal tumor, lipoma and ectopic pancreas, schwannoma, cyst, neuroendocrine tumor, varicosity, granular cell tumor, hemangioma, can be treated with endoscopic surgery, and the treatment is safe and effective.]]> 2019/3/4 16:47:08 WU Jia-xun, LU Gao-feng, TANG Fu-ai, et al. 91true ［Abstract］　Objective　To explore the indications and clinical effects of minimally invasive posterior approach single-segmental pedicle screw implantation on treatment of thoracolumbar fractures. Methods　Twenty-one cases of thoracolumbar fractures receiving minimally invasive posterior approach single-segmental pedicle screw implantation surgery were collected in our hospital from March 2013 to November 2016 and their clinical data were analyzed retrospectively. CT and MRI showed no need for spinal canal decompression. The evaluations of indicators including intraoperative blood loss, operative time, average hospitalization time, postoperative complications, Visual Analogue Scale(VAS) scores, Cobb′s angle and height loss rate of anterior edge of injured vertebrae were analyzed. Results　All the patients had a successful operation. No complications, such as internal fixation failure and nerve damage, were found after surgery. Nineteen patients were followed up and the median follow up was (17.6±5.12)months (ranges from 8 to 27 months). The mean operation time, intraoperative blood loss, and hospitalization time were (84.28±20.60)minutes, (140.51±56.94)ml and (7.28±1.69)days. The VAS scores decreased from preoperative average (7.57±0.82) to postoperative average (2.78±0.95)(P<0.05), the average loss rate of anteriov height of injured vertebrae decreased from (30.53±7.88)% before operation to (5.52±1.53)% after operation(P<0.05), the Cobb′s angle of kyphosis decreased from (18.47±4.18)° to (5.84±1.69)° after operation(P<0.05). At the last follow-up, the average VAS scores were (1.26±0.44)points, and the average loss rate of injured vertebrae was (7.26±1.74)%, and the average Cobb′s angles of kyphosis were (7.53±1.98)°, with significant differences compared with those before operation. Conclusion　Minimally invasive approach single-segmental pedicle screw implantation has a satisfactory clinical effect on treatment of thoracolumbar fractures. It has the advantages of small trauma, less bleeding and short hospitalization time.]]> 2019/3/4 16:47:08 LIN Song, WU Qiang, MIAO Ji-xian, et al. 90true ［Abstract］　Objective　To investigate the effects of ultrasound-guided lumbar-sciatic nerve block on hemodynamics and stress in elderly patients with hip fractures. Methods　A prospective study was performed on 63 elderly patients with hip fractures in the Department of Orthopedics of Sichuan Provincial People′s Hospital from June 2016 to December 2017 and the patients were divided into control group(n=32) and treatment group(n=31) using a random number table. The control group underwent conventional combined spinal and epidural anesthesia. The observation group underwent ultrasound-guided anesthesia with lumbar plexus combined with sciatic nerve block. The hemodynamic related indicators［mean arterial pressure(MAP), systolic blood pressure(SBP), pulse oximetry(SpO₂) and heart rate(HR) and stress response related indicators［blood sugar(GLU), interleukin-6(IL-6) and cortisol(COR) levels］ and Postoperative Simple Mental Condition Checklist(MMSE) and Visual Analogue Scale(VAS) were compared between the two groups before and after anesthesia. Results　There were no significant differences in hemodynamic parameters and stress response related indicators between the two groups before anesthesia(P>0.05). After anesthesia, the MAP and SBP levels and stress response related indicators were significantly different between the two groups(P<0.05). There were no significant differences in SpO₂ and HR between the two groups(P>0.05). The MMSE scores were significantly higher and the VAS scores were significantly lower in the treatment group than those in the control group 12 and 24 hours after operation（P<0.05）. Conclusion　Ultrasound-guided lumbar-sciatic nerve block has certain advantages and is worthy of clinical application.]]> 2019/1/31 16:31:42 ZHOU Qin, XIE Min, HUANG Jian-xin 89true ［Abstract］　Objective　To analyze the risk factors of postoperative complications following transabdominal preperitoneal prosthesis(TAPP). Methods　336 patients with inguinal hernia treated with TAPP in our hospital from December 2015 to December 2017 were enrolled. All the patients were followed up for 3 to 6 months after operation, and the incidence of postoperative complications such as infection and pain were observed during this period. The risk factors related to postoperative complications were analyzed. Results　The incidence of postoperative complications in hernia patients with severe adhesion and high body mass index was significantly higher than that in hernia patients with mild adhesion and low body mass index(P<0.05). There were no significant differences in the incidence rates of postoperative complications among the patients with different ages, types of hernia, sizes of hernia sac, anesthesia and patch types(P>0.05). Logistic regression analysis showed that severe adhesions of hernia ring and body mass index >24 kg/m² were the risk factors of postoperative complications following TAPP. Conclusion　Severe adhesions of hernia ring, body mass index >24 kg/m² and the diameter of hernia ring >5 cm are the risk factors of postoperative complications following TAPP.]]> 2019/1/31 16:31:42 ZHU Gong-yuan, YANG Si-qing, NING Hai-wen, et al. 88true ［Abstract］　Objective　To study the correlation between hypersensitive C reactive protein(hs-CRP) and cystatin C(Cys-C) in coronary heart disease. Methods　Two hundred and eighteen patients with coronary heart disease were collected as coronary heart disease group from August 2017 to January 2018. The patients in the coronary heart disease group were divided into three subgroups according to Gensini scores: mild lesion group(Gensini scores≤30 points, n=77), moderate lesion group(Gensini scores=30～48 points, n=69) and severe lesion group(Gensini scores≥48 points, n=72). 48 healthy subjects during the same period were selected as control group. hs-CRP and Cys-C were determined by immunoturbidimetry. Results　The levels of hs-CRP and Cys-C in the coronary heart disease group were significantly higher than those in the control group(P<0.05). Compared with those in the mild lesion group and the moderate lesion group, the levels of hs-CRP and Cys-C in the severe lesion group were significantly evelated(P<0.05). Compared with those in the mild lesion group, the levels of hs-CRP and Cys-C in the moderate lesion group were significantly elevated(P<0.05). Conclusion　hs-CRP and Cys-C are significantly correlated with the severity of coronary heart disease.]]> 2019/1/31 16:31:42 SUN Ya-zhao, SUN Dong-xu, HUANG Shu-tian, et al. 87true ［Abstract］　Objective　To study the clinical characteristics of secondary pulmonary diffuse large B-Cell lymphoma(SPDLBCL) misdiagnosed as lung cancer and the causes of misdiagnosis. Methods　The clinical data of 9 SPDLBCL patients who were misdiagnosed as lung cancer in our hospital were retrospectively analyzed. Results　There were 5 males and 4 females(5∶4), without a history of smoking. 6 patients had no previous immune system disease. The main symptoms were cough, expectoration, fever, wheeze, chest pain and hoarse voice and the main signs were superficial lymph node enlargement, decreased breath sounds and rales in the side of the lungs. Laboratory examination demonstrated decreased lymphocyte counts in 6 cases while elevated lactic acid dehydrogenase(LDH) in 8 cases. Chest CT showed tumors in 7cases(multiple in 1 case), patchy shadows in 6 cases, bronchostenosis in 3 cases, pleural effusion in 3 cases, and enlarged mediastinal or hilar lymph nodes in 6 cases. CT scan depicted multiple nodules located in bilateral lungs in 2 cases, enlarged mediastinal or hilar lymph nodes in 1 case. 7 cases were formed enhanced CT scans and the lesions showed no enhancement in 1 case, obvious enhancement in 1 case and uneven enhancement in 4 cases. All the cases were diagnosed as SPDLBCL by pathology and immunohistochemistry, among whom 4 cases were diagnosed by lymph node biopsy, 3 patients by CT-guided percutaneous pulmonary biopsy and 2 patients by tracheoscopy. Conclusion　SPDLBCL is rare clinically and CT can not provide a definitive diagnosis due to nonspecific clinical and CT findings. However, the possibility of SPDLBCL should be highly considered when the mass or nodule with irregular margin and uneven enhancement, surrounding patchy shadows are observed on the chest CT scan. The final diagnoses depend on pathological and immunohistochemical examinations.]]> 2019/1/31 16:31:42 ZHANG Xiang-e, HUANG Song-ping 86true ［Abstract］　Objective　To investigate the effect of Shenqiyixin decoction on chronic congestive heart failure in patients with normal ejection fraction. Methods　Ninety-four patients who were diagnosed with chronic congestive heart failure but with normal ejection fraction were selected, and were randomly divided into Chinese Medicine group and Western Medicine group, with 47 cases in each group. The Chinese Medicine group was treated with Traditional Chinese Medicine Shenqiyixin decoction. The Western Medicine group was treated with nitroglycerin, diuretic and angiotensin-converfing enzyme inhibitor(ACEI), with 4 weeks for a course and a total of 3 courses of treatment. The changes of clinical indexes of left ventricular function and plasma NT-proBNP levels during and after treatment, and the curative effect were compared between the two groups. Results　The levels of LVEF, PEF after treatment were obviously higher than those before treatment in the two group, while the levels of TPER were obviously lower than those before treatment(P<0.05). The levels of LVEF and PEF were obviously higher and the level of TPER was obviously shorter in the Chinese Medicine group than those in the Western Medicine group(P<0.05). There were no significant differences in the plasma levels of NT-proBNP between the two groups before treatment, but they were significantly reduced in both of the two groups after treatment(P<0.05). The improvement of NT-proBNP in the Chinese Medicine group was better than that in the Western Medicine group(P<0.05). In the Chinese Medicine group, 26 cases were markedly effective, 18 cases effective and 3 cases ineffective. In the Western Medicine group, 17 cases were markedly effective, 21 cases effective and 9 cases ineffective. The curative effect of the Chinese Medicine group was better than that of the Western Medicine group(P<0.05). Conclusion　Modified Shenqiyixin decoction is effective on chronic congestive heart failure and improves cardiac function and increases activity tolerance in the patients who are diagnosed with chronic congestive heart failure but with normal ejection fraction.]]> 2019/1/31 16:31:42 LIU Jing-mei, LI Yu-xian 85true ［Abstract］　Objective　To explore the influencing factors of neoadjuvant chemotherapy for breast cancer, and to provide reference for improving the effect of neoadjuvant chemotherapy. Methods　The medical records data of 78 female breast cancer patients who received neoadjuvant chemotherapy in our hospital from April 2014 to October 2018 were retrospectively analyzed. The patients were divided into pCR group(n=13) and non-pCR group(n=65) according to their pCR(pathologic complete response) status. The patients were divided into(CR+PR) group(n=49) and non-(CR+PR) group(n=29) according to their clinical efficacy. Logistic regression analysis was used to analyze the influencing factors of pCR and clinical efficacy. Results　Among the 78 patients, 13 cases got pCR(16.7%) and 49 cases were clinically effective(62.8%). The proportion of the patients with tumor diameters ≤5 cm, Ki-67>30% and non-Luminal type in the pCR group was significantly higher than that in the non-pCR group(P<0.05). The results of Logistic regression analysis showed that the patients with tumor diameters >5 cm and positive lymph node status were the disadvantageous factors for obtaining pCR, while with non-Luminal type was the positive factor for the patients more likely to get pCR(P<0.05). In addition, the proportion of the patients with chemotherapy cycles ≥6, Ki-67>30% and non-Luminal type in the(CR+PR) group was significantly higher than that in the non-(CR+PR) group(P<0.05), and the chemotherapy regimens were significantly different between the two groups(P<0.05). Logistic regression analysis did not find the influencing factors for the patients to obtain clinical effectiveness. Conclusion　Molecular typing, tumor diameter and lymph node status are the factors affecting getting pCR after neoadjuvant chemotherapy, and these indicators should be evaluated before treatment. The patients with taxus-containing chemotherapy regimen, long period of chemotherapy(6 cycles or more) and high Ki-67 expression(>30%) are more likely to achieve clinical effectiveness.]]> 2019/12/30 10:12:41 SHI Hao, WANG Xiao-hui, GU Jun-wei, et al. 84true ［Abstract］　Objective　To observe the adverse reactions of bronchial dilation test and explore its safety. Methods　The adverse reactions of 1 109 patients receiving bronchial dilation test in our hospital from June 2017 to December 2018 were evaluated by questionnaire survey. The items investigated mainly included general clinical data, symptoms and degree of adverse reactions, treatment measures, recovery and whether they were fasting, etc. Results　A total of 155 adverse reactions were recorded in 132 cases(11.9%), among whom 21 cases had two or three adverse reactions.The highest incidence of adverse reactions was neuromuscular symptoms, followed by cardiovascular symptoms. 47 cases of tremor in both hands and 36 cases of tachycardia occurred in 4.2% and 3.2%, respectively. The incidence of adverse reactions in the fasting group was higher than that in the non-fasting group. There were significant differences between the two groups in tremor in both hands and tachycardia(χ²=8.950, P=0.003; χ²=5.527, P=0.019). Mild and moderate adverse reactions accounted for 83.9% and 16.1% respectively, with no severe adverse reactions. Conclusion　Bronchial dilation test may cause adverse reactions, but most of them are mild. Bronchial dilation test is safe.]]> 2019/12/30 10:12:41 ZHU Ya-jing, LIU Juan 83true ［Abstract］　Objective　To explore the clinical effect of total knee arthroplasty(TKA) with screw on severe knee varus deformity with tibial plateau settlement. Methods　From August 2016 to January 2019, 11 female patients(16 knees) with knee varus deformity and tibial plateau subsidence were selected and were treated with TKA. According to the X-ray films, the preoperative and postoperative knee varus angles were compared. The clinical scores ［(40.28±11.34)points］, the function scores ［(48.32±15.54)points］, the range of motion(ROM) ［(89.76±14.13)°］, and the femoral tibia angles(FTAs) ［(15.04±3.38)°］ were scored or measured by Knee Society Scoring System(KSS). Results　The operation time was 75～90 min, with an average of 80 min. The amount of dominant blood loss was 200～700 ml, with an average of 430 ml. The length of hospital stay ranged from 10 to 15 days, with an average of 12.5 days. The patients were followed up for 6 to 21 months, with an average of 15 months. The FTA of knee joint was (5.87±1.10) ° measured by reexamination of X-ray film, and axial alignment of the lower extremity recovered to normal. No loosening or sinking of prosthesis was found during the follow-up. At the time of the last follow-up, the clinical scores were (87.33±5.42)points; the function scores were (89.45±5.94)points and the ROM were (107.54±10.68)° using KSS; the differences were statistically significant compared with those before operation. Conclusion　For the patients with knee varus deformity and tibial plateau settlement, the axial alignment of the lower extremity recovers well, and the settlement of small tibial plateau is supported by screws and cement. The range of motion, stability and functional recovery of the knee joints are satisfactory.]]> 2019/12/30 10:12:41 LUO Deng-ke, ZOU Ji, CHEN Ken, et al. 82true ［Abstract］　Objective　To investigate the effects of different input arteries on perfusion parameters of central lung cancer. Methods　Computed tomography(CT) perfusion imaging was performed in 48 patients with primary central lung cancer. The thoracic aorta and the main pulmonary trunk were selected as the input arteries for perfusion analysis, and the perfusion parameters of the same lesions and different pathological types were compared. Results　The BF value of lung cancer with the thoracic aorta as the input artery was higher than that with the main pulmonary artery as the input artery(P<0.05). The PS, TTP and MTT values of lung cancer with the thoracic aorta as the input artery were lower than those with the main pulmonary artery as the input artery(P<0.05). The BV of lung cancer with the thoracic aorta as the input artery was slightly lower than that with the main pulmonary artery as the input artery, but the difference was not statistically significant(P>0.05). Among the 48 cases of central lung cancer, 13 cases were small cell carcinoma, and 16 cases were squamous cell carcinoma and 19 cases were adenocarcinoma. There were no significant differences in the perfusion parameters of different pathological types when the thoracic aorta was used as the input artery(P>0.05), and there were no significant differences in the perfusion parameters of different pathological types when the main pulmonary artery was used as the input artery(P>0.05). Conclusion　It is found that the perfusion parameters of central lung cancer are affected by different input arteries. In the study of central lung cancer with single port perfusion software, thoracic aorta should be chosen as the input artery. Perfusion parameters are not applicable to the assessment of the pathological types of central lung cancer.]]> 2019/12/30 10:12:41 YANG Ting, WANG Xin-wen, MA Ai-xin, et al. 81true ［Abstract］　Objective　To compare the effects of trifocal intraocular lens and bifocal intraocular lens on the early visual quality in elderly patients after cataract surgery. Methods　Twenty cataract patients receiving phacoemulsification combined with intraocular lens implantation were selected, and were divided into two groups according to different treatment methods among whom 10 patients receiving AT LISA tri 839MP intraocular lens implantation were taken as the observation group, and 10 patients receiving AT LISA 809M intraocular lens implantation as the control group. The therapeutic effects were compared between the two groups 3 months after operation. Results　The uncorrected intermediate vision acuity of the observation group was better than that of the control group(P<0.05). The observation group was better than the control group in the degree of dependence on glasses and visual satisfaction scores(P<0.05). Conclusion　Trifocal intraocular lens can help senile cataract patients to obtain the whole vision, especially intermediate vision, and improve their visual quality satisfaction.]]> 2019/11/28 12:01:08 CHEN Xuan 80true ［Abstract］　Objective　To compare mini mental state examination(MMSE), montreal cognitive assessment(MoCA), mini cognitive assessment test(Mini-cog) and clock drawing test(CDT) in the evaluation of cognitive impairment of elderly inpatients, and to make a simple, easily understandable and suitable comprehensive geriatric assessment(CGA) scale for the elderly inpatients in China. Methods　CGA scale was used to evaluate the hospitalized patients aged 75 years or more in the Geriatric Department of Guangdong Provincial People′s Hospital from April 2017 to August 2018, and MMSE, MoCA, Mini-cog and CDT were used in each patient′s cognitive assessment. The sensitivity, specificity, Kappa coefficient and Youden index were calculated based on the evaluation results. The area under the curve(AUC) was determined by the receiver operating characteristic curve(ROC). Results　Of the 225 patients evaluated, 107 were cognitively impaired. The sensitivity of MMSE in screening cognitive impairment was 0.76; the specificity was 0.93, and the Youden index was 0.69. The sensitivity and specificity of MoCA in screening cognitive impairment were 0.97 and 0.41 respectively, and the Youden index was 0.38. The sensitivity of Mini-cog in screening cognitive impairment was 0.72; the specificity was 0.79, and the Youden index was 0.51. The sensitivity of CDT in screening cognitive impairment was 0.63; the specificity was 0.74 and the Youden index was 0.37. Compared with that of the actual cognitive status, the Kappa coefficient of MMSE in screening cognitive impairment was the highest(0.695), followed by that of Mini-cog(0.509), and the Kappa coefficient of MoCA was the lowest(0.368). Conclusion　MMSE has higher sensitivity, specificity, authenticity and better consistency than the other cognition screening scales, followed by Mini-cog. Therefore, MMSE can be used to screen the patients with cognitive impairment when CGA is carried out in the elderly patients aged 75 and over. If it is positive, further assessment can be made on the cognitive aspect.]]> 2019/11/28 12:01:08 FU Ji-ping, CHEN An-ni, CHEN Jie-fen, et al. 79true ［Abstract］　Objective　To explore the short-term effects of unicompartmental knee arthroplasty(UKA) and total knee arthroplasty(TKA) in treatment of medial compartmental knee osteoarthritis. Methods　A retrospective analysis of 15 medial compartmental knee osteoarthritis patients(15 knees) treated with unicompartmental knee arthroplasty(UKA) from January 2017 to October 2017 was performed. Thirty patients(34 knees) treated with total knee arthroplasty(TKA) over the same period were selected as the control group. The pain Visual Analogue Scale(VAS) scores, Hospital for Special Surgery(HSS) scores and range of motion(ROM) in the two groups were evaluated and recorded before operation. The time of operation, intraoperative hemorrhage, hemoglobin decrease 3 days after operation, VAS scores 3 months and 1 year after operation, HSS scores and ROM were recorded. Results　All the patients were successfully completed the operation. There were no significant differences in age and body mass index(BMI) between the two groups(P>0.05). The time of operation in the UKA group was significantly shorter than that in the TKA group(P<0.05). The amount of intraoperative bleeding in the UKA group was significantly less than that in the TKA group(P<0.05). The level of hemoglobin decrease 3 days after operation and VAS scores in the UKA group were significantly lower than those in the TKA group(P<0.05). However, HSS scores and ROM in the UKA group were significantly higher than those in the TKA group(P<0.05). Conclusion　UKA has better short-term effectiveness than TKA in the treatment of medial compartmental knee osteoarthritis. UKA has the advantages of shorter operation time, less intraoperative bleeding, faster postoperative recovery and better functional recovery, and achieves better short-term results.]]> 2019/11/28 12:01:08 ZHANG Xin-an, LIAN Hong-kai, LIU Yun-tao, et al. 78true ［Abstract］　Objective　To compare the clinical effects of three kinds of resection for previous cesarean scar defects(PCSD). Methods　A total of 45 patients who suffered from PCSD were enrolled into this study from December 2014 to December 2017, among whom 15cases were performed laparotomy(group A), and 15 cases were performed hysteroscopy combined with laparoscopy(group B), and 15 cases were performed vaginal surgery(group C). The operation time, intraoperative blood loss, postoperative vaginal bleeding volume, postoperative anal exhaust time, hospitalization time, hospitalization costs and cure rate were compared among the three groups. Results　The intraoperative blood loss, postoperative vaginal bleeding and hospitalization costs in group A were significantly higher than those in group B and group C(P<0.05). The operation time and postoperative hospitalization time in group A was significantly longer than that in group B and group C(P<0.05). The postoperative anal exhaust time in group A was significantly earlier than that in group B and group C(P<0.05). The operation time and hospitalization time in group B was significantly longer than that in group C(P<0.05). The hospitalization costs in group B were higher than those in group C(P<0.05). The postoperative anal exhaust time in group B was significantly later than that in group C(P<0.05). There were no significantly differences between group B and group C in the intraoperative blood loss and postoperative vaginal bleeding volume(P>0.05). Among the three groups, group C had the shortest the operation time and postoperative hospitalization time and the earliest postoperative anal exhaust time. Conclusion　Each of the three types of minimally invasive surgery has its advantages, and they have high cure rates. Laparotomy is the easiest way and has the clearest vision and lowest hospitalization costs but causes the largest blood loss and the patients have the slowest postoperative recovery and the longest hospital stay. Hysteroscopy combined with laparoscopic operation has the longest operative time and highest hospitalization costs, but the patients have the smallest damage and quickest recovery. The hospitalization costs of the patients receiving vaginal surgery are moderate and their curative effects are definite, but the disadvantages of the operation are small visual field and exposure. The appropriate operation method should be selected according to the actual situation of the patients.]]> 2019/11/28 12:01:08 LIU Yuan-yuan, ZHAO Ren-feng 77true ［Abstract］　Objective　To explore the drug loading properties of multi-functional nanometer material pegylated FeS(FeS-PEG) nanoparticles with good biocompatibility, and the effect of doxorubicin(DOX) on the proliferation, endocytosis and apoptosis of tumor cell 4T1 after anti-tumor drug DOX was carried by FeS-PEG. Methods　Nanostructured FeS was synthesized by high temperature synthesis, and FeS-PEG was obtained by crosslinking modification of FeS layer by layer. The cytotoxicity and drug loading properties of FeS-PEG were analyzed, and the endocytosis of the loaded drugs and apoptosis were detected. Results　The drug loading rate of the anti-tumor drug DOX loaded by FeS-PEG nanomaterials was 134%. The loaded drugs were released by 7.13% if pH = 7.4, by 10.94% if pH=6, by 24.53% if pH=5. The drugs loaded by FeS-PEG could retain DOX in the cytoplasm. The percentage of apoptosis promoted by free DOX culture was (5.1±0.72)%, while that by the drugs loaded with FeS-PEG was (31.28±2.28)%. Conclusion　FeS-PEG nanomaterials can carry small molecule drugs, change the retention site of small molecule drugs in cells, and retain small molecule drugs in cytoplasm. In addition, the nanomaterials can obviously promote cell apoptosis after drug loading, so as to enhance the long-term killing effect of drugs on tumor cells, which has a great application prospect in drug delivery.]]> 2019/11/28 12:01:08 LI Mei-fang, SHEN Wei-qiang 76true ［Abstract］　Objective　To summarize the surgical treatment experience and misdiagnosis analysis of primary hyperparathyroidism(PHPT). Methods　Eighteen PHPT patients admitted to the Affiliated Hospital of Qinghai University from January 2013 to December 2016 were collected, and their clinical manifestations, laboratory examination, imaging examination, treatment methods and follow-up results were retrospectively analyzed. Results　Of the 18 patients, 8 underwent surgical treatment, and the patients were followed up for 2～5 years. After the follow-up, no recurrence and reoperation occurred. The other 10 patients were not treated with any drugs during the follow-up, but their symptoms were not obviously aggravated and the quality of life was still good. Conclusion　Most patients with PHPT are caused by parathyroid adenoma, and surgery is still the main treatment. A large number of PHPT patients still have no any symptoms, or their symptoms are not typical, among whom the indications for surgery and medication are still unclear.]]> 2019/10/30 10:56:24 LI Zi-tao, MA Zhi-jun, LIU Zhen, et al. 75true ［Abstract］　Objective　To compare the safety and feasibility of transperitoneal and retroperitoneal approaches for laparoscopic resection of giant adrenal tumors, and to evaluate the effect of the operations. Methods　Eighty-seven patients with giant adrenal tumors were collected in Luoyang Central Hospital Affiliated to Zhengzhou University from October 2010 to May 2017 and their surgical data were retrospectively analyzed among whom transperitoneal adrenalectomy was performed in 47 cases and anatomic adrenalectomy by retroperitoneal laparoscopy was performed in 40 cases. The operation time, intraoperative blood loss, postoperative feeding recovery time and postoperative hospital stay were compared between the two operation methods. Results　All the operations of the 87 cases were successfully completed without obvious complications. The operation time of the transperitoneal approach was significantly shorter than that of the retroperitoneal approach(P<0.05). The intraoperative blood loss in the patients treated with the transperitoneal approach was significantly less than that in the patients treated with the rettoperitoneal approach(P<0.05). The time of postoperative feeding recovery and postoperative hospital stay in the patients with retroperitoneal approach significantly shorter than that in the patients treated with the transperitoneal approach(P<0.05). Conclusion　Both approaches can be used to resect adrenal tumors, and the surgical approaches should be selected according to the nature of the lesion, tumor size, location and the patients′ specific conditions.]]> 2019/10/30 10:56:24 WEI Peng-tao, LI Qi, ZHANG Han, et al. 74true ［Abstract］　Objective　To observe the anesthetic effect and safety of different doses of fentanyl combined with sevoflurane for general anesthesia without intubation in children undergoing daytime surgery. Methods　Sixty pediatric patients undergoing daytime surgery in our hospital were randomly divided into three groups(S group, SF1 group and SF2 group, with 20 cases in each group) by the random number table method. After sevoflurane induced sleep, the above three groups were given normal saline, fentanyl 1 μg/kg and 1.5 μg/kg as combined maintenance anesthesia, and the non-intubated mask was closed to give oxygen ventilation. The incidence of body tremor during skin incision, the vital signs and waking time of the patients after skin incision were recorded. Results　The time of recovery during operation, the blood pressure, the heart rate and the incidence of body tremer during skin incision and the sevoflurane dosage in SF1 group and SF2 group was significantly lower than that in S group(P<0.05). There was no significant difference in the ratio of mandibular support among the three groups(P>0.05). However, there were 2 cases of laryngeal spasm in S group, which was relieved after treatment. Conclusion　Fentanyl combined with sevoflurane can be safely used for non-intubated general anesthesia in children undergoing daytime surgery, and improve the comfort of children after anesthesia.]]> 2019/10/30 10:56:24 DONG Li, HUANG Yuan, ZENG Li, et al. 73true ［Abstract］　Objective　To explore the safety and long-term outcomes of thoracolaparoscopic esophagectomy and open esophagectomy in treatment of esophageal carcinoma. Methods　A total of 544 patients with esophageal squamous cell carcinoma admitted to the Department of Thoracic Surgery of Anyang Tumor Hospital from March 2014 to June 2018 were studied among whom 122 cases were enrolled as thoracoscopic and laparoscopic esophagectomy(TLE) group receiving TLE and using propensity score matching analysis method, other 122 cases as one on one matching open group(OE group) receiving open esophagectomy(OE). McKeown procedure was used in both surgical procedures. The perioperative related indexes were collected and the survivals followed up for 1～3 years. Results　After matching the propensity score, TLE group had less intraoperative bleeding, shorter postoperative hospital stay, lower incidence rates of cardiopulmonary complications and total complications, and more lymph node dissection than OE group, all of which were statistically significant（P<0.05）. There were no statistically significant differences in the operation time, postoperative pleural fluid volume anastomotic fistula, chylothorax, and 30-day hospital mortality between the two groups（P>0.05）. The 1-year, 2-year and 3-year survival rates in TLE group were 95.1%, 74.6% and 57.4% respectively, while those in OE group were 94.3%, 70.5% and 47.5% respectively. There was no significant difference in 3-year cumulative survival rate between the two groups(P=0.095). Conclusion　Thoracolaparoscopy is safe and reliable for esophagectomy. Compared with open surgery, it can significantly reduce the incidence of cardiopulmonary complications and achieve a long-term survival rate similar to that of open surgery.]]> 2019/10/30 10:56:24 ZHENG Xiao-dong, ZHANG Wei-min, HOU Jian-bin 72true ［Abstract］　Objective　To observe the clinical effects of antibiotics combined with initial periodontal therapy(IPT) on moderate to severe chronic periodontitis(CP) complicated with type 2 diabetes mellitus(T2DM). Methods　Sixty-four patients with moderate to severe CP complicated with T2DM who were treated in our hospital from January 2015 to December 2016 were enrolled. The patients were randomly divided into observation group and control group, with 32 cases in each group. The patients in the observation group were given antibiotics(oral metronidazole tablets+amoxicillin capsules) in combination with IPT, while the control group only underwent IPT. The changes of periodontal indexes［periodontal pocket depth(PD), plague index(PLI); sulcus bleeding index(SBI)］, glucose metabolism indexes［fasting blood glucose(FPG), glycosylated hemoglobin A1c(HbA1c)］ and inflammatory factors［high sensitive C-reactive protein(hs-CRP), tumor necrosis factor(TNF-α)］ were compared between the two groups before treatment and one month after treatment. Results　At 1 month after treatment, the levels of the periodontal indexes(PD, PLI, SBI), glucose metabolism indexes(FPG, HbA1c) and inflammatory factors(hs-CRP, TNF-α) in the two groups were significantly lower than those before treatment(P<0.05); compared with those in the control group, the levels of the above indexes in the observation group were significantly lower(P<0.05). Conclusion　Antibiotic combined with IPT can significantly reduce the periodontal indexes of the patients with moderate to severe CP and T2DM, and effectively improve glucose metabolism, which is beneficial to the disease outcome.]]> 2019/10/30 10:56:24 SU Jia-nan 71true ［Abstract］　Objective　To observe the comparative effects between laparoscopic surgery after intestinal decompression using small intestinal decompression tube and emergency laparotomy in patients with right-sided colon cancer and obstruction during perioperative period. Methods　Seventy-six patients with obstructive right-sided colon cancer receiving surgical treatment between December 2012 and December 2018 in the Department of General Surgery of the People′s Hospital of Guangxi Zhuang Autonomous Region were included in this study. The patients were divided into the intestinal decompression tube surgery group(n=30) receiving laparoscopic radical resection of right-sided colon cancer after preoperative decompression by intestinal decompression tube and the control group receiving emergency laparotomy(n=46). The preoperative serum albumin levels, preoperative electrolyte status, average operation time, blood loss, number of lymph node dissection, average drainage 3 days after surgery, postoperative anal exhaust time, postoperative complications, total length of hospital stay and total hospital costs were compared between the two groups. Results　Preoperative hypoproteinemia and electrolyte disturbance in the intestinal decompression tube surgery group improved better than those in the control group. The average operation time in the intestinal decompression tube surgery group was significantly shorter than that in the control group［(183.3±21.1)minutes vs (222.7±25.7)minutes, P<0.01］. The blood loss in the intestinal decompression tube surgery group was significantly less than that in the control group ［(105.5±34.3)ml vs (226.2±64.7)ml, P<0.01］. The number of lymph nodes dissected in the intestinal decompression tube surgery group was significantly increased compared with those dissected in the control group［(21.9±3.8)nodes vs (20.1±2.9)nodes, P<0.05］. The average drainage volume in the intestinal decompression tube surgery group 3 days after surgery was significantly less than that in the control group［(112.3±44.6)ml/d vs (170.5±46.0)ml/d, P<0.01］. The postoperative anal exhaust time in the intestinal decompression tube surgery group was significantly shorter than that in the control group［(2.4±1.0)d vs (4.2±0.9)d, P<0.01］. There were no significant differences in the total length of hospital stay and the total hospital costs between the two groups(P>0.05). Conclusion　For the patients with right-sided colon cancer and obstruction, preoperative gastrointestinal decompression by intestinal decompression tube is helpful to reduce the symptoms of preoperative abdominal distension and gains time to correct the preoperative imbalance of the patients and time for creating conditions for laparoscopic minimally invasive surgery. Laparoscopic surgery has shorter operation time, less intraoperative bleeding, more lymph nodes dissected, faster postoperative recovery, but does not increase the length of hospital stay and the hospital costs.]]> 2019/10/30 10:56:24 LIU Chao, FENG Ze-rong 70true ［Abstract］　Objective　To observe the clinical curative effects of oral glucocorticoids on treatment of patients with post-herpetic neuralgia(PHN). Methods　Ninety patients with PHN who were treated in our hospital from December 2018 to October 2019 were randomly divided into observation group and control group, with 45 cases in each group. Both groups were given intramuscular injection of vitamin B₁ and cobamamide, and red light irradiation therapy was given at the same time. In the observation group, oral treatment with prednisone acetate tablets was added for 2 weeks. The pain degree and clinical efficacy were evaluated by Visual Analogue Scale(VAS) score. Results　There were no significant differences in VAS scores between the two groups before treatment(P>0.05). After 1 week and 2 weeks of treatment, the VAS scores of the observation group were significantly lower than those of the control group(P<0.05). The total effective rate of the observation group was significantly higher than that of the control group(95.6% vs 80.0%, P<0.05). No serious adverse reactions were found in the two groups. Conclusion　Treatment with oral glucocorticoids is effective for the patients with PHN, which can effectively reduce the degree of pain and has less adverse reactions in short-term use.]]> 2020/9/30 16:48:19 GE Jing, HUANG Yong 69true ［Abstract］　Objective　To analyze the diagnosis and treatment methods of colorectal diffuse cavernous hemangioma. Methods　From January 2010 to January 2019, the data of 8 colorectal diffuse cavernous hemangioma patients undergoing surgical treatment at our hospital were retrospectively analyzed. Results　The eight patients diagnosed with colorectal diffuse cavernous hemangioma were treated with surgery, and all the patients recovered well after the operation. No patients needed blood transfusion after the operation. Stool control could be done 2～3 times per day half a year after the operation. Conclusion　Preoperative examinations of enteroscopy and abdominal CT, CTV and MRI can not only confirm the diagnosis, but also determine the scope of the lesions. The best treatment for colorectal diffuse cavernous hemangioma is to remove the focus thoroughly and protect the function of the anal sphincter completely.]]> 2020/9/30 16:48:19 WU Wei, LI De-gang, PANG Li-ming 68true ［Abstract］　Objective　To observe the short-term effect and adverse reactions of anlotinib combined with tegafur gimeracil and oteracil potassium(S1) and nedaplatin on treatment of recurrent esophageal squamous cell carcinoma. Methods　From October 2018 to October 2019, 36 patients with recurrent esophageal squamous cell carcinoma after first-line radiotherapy and chemotherapy were selected and randomly divided into the observation group(treated with anlotinib+S1+nedaplatin) and the control group(treated with S1+nedaplatin), with 18 cases in each group. The curative effect and adverse reactions after treatment were observed in the two groups. Results　The objective response rate(ORR) and the disease control rate(DCR) of the observation group were 16.7% and 61.1% respectively, and there was significant difference in the DCR between the observation group and the control group(P<0.05). The median progression-free survival(PFS) was 3.7 months in the observation group and 2.3 months in the control group, and there was significant difference between the two groups(P<0.05). The incidence of hypertension in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). Conclusion　Anlotinib plus S1 and nedaplatin is effective for the treatment of recurrent esophageal squamous cell carcinoma, and has few adverse reactions and the patients are tolerable.]]> 2020/9/30 16:48:19 SUN Yun-xiang, JI Jun-an, CHEN Zhao-bo, et al. 67true ［Abstract］　Objective　To compare the clinical effects on thyroid cancer between transoral endoscopic thyroidectomy via vestibular approach(TOETVA) and open surgery. Methods　Fifty patients with early papillary thyroid carcinoma treated in our hospital from January 2019 to January 2020 were divided into the endoscopy group(n=22) and the open group(n=28) according to different treatment methods. The endoscopy group underwent TOETVA for thyroid cancer, while the open group underwent traditional open surgery. The operative time, intraoperative blood loss, postoperative drainage volume, cosmetic scores and postoperative complications were compared between the two groups. Results　The operative time in the endoscopy group was significantly longer than that in the open group(P<0.05). The postoperative drainage volume in the endoscopy group was significantly larger than that in the open group(P<0.05). After operation, the Visual Analogue Scale(VAS) scores of the endoscopy group were significantly lower than those of the open group(P<0.05), and the scores of aesthetic satisfaction in the endoscopy group were significantly higher than those in the open group(P<0.05). However, there were no significant differences in the intraoperative blood loss, the length of hospital stay and the number of lymph nodes dissected between the two groups(P>0.05). There were no cases with permanent hoarseness, hematoma and permanent hypoparathyroidism in the two groups. One case in the endoscopy group had infection and one case in the open group had effusion. Conclusion　TOETVA is a safe, feasible and effective surgical method for radical thyroidectomy of thyroid cancer. It has a good cosmetic effect and is worthy of clinical promotion.]]> 2020/9/2 15:08:59 ZHAO Qing-quan, CHENG Si-xian, CHEN Yue-mei, et al. 66true ［Abstract］　Objective　To analyze the influencing factors of efficiency of platelet transfusion. Methods　The therapeutic effect of 84 patients treated with 363 platelet transfusions was observed. Using correction of platelet increment and platelet recovery rate as the quantitative judgment criteria, and combining with the clinical manifestations of hemorrhage of the patients, the influence of each clinical basic situation of the patients on the efficiency of platelet transfusion was comprehensively analyzed. Results　Binary Logistic regression analysis showed that positive bacterial culture(OR=1.752, 95%CI: 1.055～2.910), splenomegaly(OR=2.133, 95%CI: 1.035～4.395) and active hemorrhage(OR=1.784, 95%CI: 1.113～2.861) were the risk factors of platelet transfusion refractoriness(P<0.05). Conclusion　The influencing factors of efficiency of platelet transfusion are positive bacterial culture, splenomegaly and active hemorrhage.]]> 2020/9/2 15:08:59 HE Zuo-ping, LUO Pei-fang, YANG Bin 65true ［Abstract］　Objective　To observe the clinical effect of external physical vibration lithecbole(EPVL) on treatment of residual stones after flexible ureteroscopy holmium laser lithotripsy. Methods　From January 2017 to January 2020, a total of 52 patients with residual stones due to indwelling ureteral stents after flexible ureteroscopy holmium laser lithotripsy were selected and were divided into observation group and control group according different treatment methods. The observation group(n=28) was treated with EPVL after operation, and the residual stones were removed naturally after operation in the control group(n=24). The stone removal effect was compared between the two groups. Results　100.0%(28/28) of the patients expelled the residual stones on the first day of the treatment in the observation group, and 12.5%(3/24) of the patients expelled the residual stones on the first day of the treatment in the control group. The stone free rate was 67.9%(19/28) in the observation group, and that was 37.5%(9/24) in the control group on the first day of the treatment. The stone free rate was 85.7%(24/28) in the observation group, and that was 58.3%(14/24) in the control group on the first week of the treatment. The stone free rate was 96.4%(27/28) in the observation group, and that was 75.0%(18/24) in the control group on the second week of the treatment. There were significant differences between the two groups(P<0.05). Conclusion　EPVL can effectively promote the removal of residual stones after flexible ureteroscopy holmium laser lithotripsy, which is safe and reliable, and has clinical application value.]]> 2020/9/2 15:08:59 ZHU Wei, HE Ji-bao, ZHOU Xiang, et al. 64true ［Abstract］　Objective　To investigate the application value of modified Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity(POSSUM) in predicting the incidence of complications after thoracoscopic lung cancer surgery. Methods　The clinical data of 142 lung cancer patients who underwent video-assisted thoracic surgery(VATS) at the First Affiliated Hospital of Shihezi University School of Medicine from January 2016 to December 2018 were collected. The effect of each index on the incidence of postoperative complications was analyzed using binary Logistic regression. The modified POSSUM scoring system was made by excluding the indexes that were not suitable for lung surgery from the standard POSSUM scoring system and including in the selected indexes. Results　Of the 142 patients, 34 patients(23.9%) occurred postoperative complications. Logistic regression analysis showed that age(OR=2.699, 95%CI=1.121～6.496), signs of the heart(OR=3.375, 95%CI=1.513～7.526), signs of the respiratory system(OR=2.420, 95%CI=1.050～5.579), pulse rate(OR=2.600, 95%CI=1.176～5.747), scope of surgery(OR=1.350, 95%CI=1.056～1.725), volume of blood loss(OR=3.211, 95%CI=1.290～7.993), body mass index(BMI)(OR=1.199, 95%CI=1.026～1.400), the forced expiratory volume in 1 sencond(FEV₁)/forced vital capactity(FCV) ratio(%)［FEV₁/FVC(%)］(OR=2.965, 95%CI=1.203～7.308) and time of operation(OR=2.518, 95%CI=1.117～5.672) were the independent risk factors for postoperative complications(P<0.05). The receiver operating chacracteristic(ROC) area under the curve(AUC) of the modified POSSUM scoring system was (0.710±0.051)［95%CI(0.628～0.783)］, and that of the standard POSSUM scoring system was (0.649±0.055)［95%CI(0.565～0.727)］, with a statistically significant difference(P<0.05). Conclusion　The modified POSSUM has a good predictive value for the occurrence of postoperative complications in lung cancer patients after thoracoscopic surgery, and can provide the clinicians with the basis for preoperative decisionmaking.]]> 2020/8/3 9:08:34 ZUO Yan-song, HOU Liang, YIN Lai-bo, et al. 63true ［Abstract］　Objective　To observe the expressions of messenger ribonucleic acid(mRNA) and protein of glycogen synthesis kinase-3 beta(GSK3β) in lung adenocarcinoma tissues, and to explore their clinical significances in the occurrence and development of lung adenocarcinoma. Methods　The cancer tissue samples of 55 patients with lung adenocarcinoma were randomly selected as the experimental group and the matched normal tissue samples beside the cancer tissues as the control group. The relative expressions of GSK3β mRNA in the two groups were detected by reverse transcription-polymerase chain reaction(RT-PCR). The relative expressions of GSK3β protein in the two groups were detected by Western blot. Results　The relative expressions of GSK3β mRNA and GSK3β protein were (0.366±0.138), (0.460±0.242) in the experimental group respectively, and (0.485±0.137) and (0.689±0.183) in the control group respectively. The expressions of GSK3β mRNA and GSK3β protein in the experimental group were significantly lower than those in the control group(P<0.01). The relative expressions of GSK3β mRNA and GSK3β protein in the patients with stage Ⅰ～Ⅱ lung adenocarcinoma were significantly higher than those in the patients with stage Ⅲ lung adenocarcinoma(P<0.01). Conclusion　The expression of GSK3β is down-regulated in lung adenocarcinoma tissues compared with that in the matched normal tissues beside the cancer tissues, and the expression of GSK3β decreased with the increase of clinical stages, suggesting that GSK3β may inhibit the occurrence and development of lung adenocarcinoma, and that increasing the expression of GSK3β may benefit the treatment of lung adenocarcinoma.]]> 2020/8/3 9:08:34 SHANG Zi-qiang, ZHOU Yan, ZHANG Can-bin, et al. 62true ［Abstract］　Objective　To evaluate the clinical effects of posterior limited decompression, short segment fixation and fusion surgery on lumbar degenerative scoliosis. Methods　Twenty-two patients with lumbar degenerative scoliosis admitted to our hospital from December 2012 to August 2014 were collected. All the patients underwent preoperative X-ray, computed tomography(CT) and magnetic resonance imaging(MRI) examinations, and were treated with posterior limited decompression, short segment fixation and fusion surgery. The patients were followed up and Visual Analogue Scale(VAS) and Oswestry Disability Index(ODI) scoring systems were used to evaluate the therapeutic effects. Results　All the patients were followed up for 24～60 months, with an average of 34.8 months. The operation time was 78～208 min, with an average of 138.5 min, and the bleeding volume was 250～1 000 ml, with an average of 433 ml. At the last follow-up after surgery, the mean Cobb′s angle (17.83±11.38)°, lumbar lordosis angle (37.04±15.27)°, sagittal vertical axisc(SVA) (36.99±31.20)mm were all significantly different from those before surgery(P<0.05). At the last follow-up after surgery, the VAS scores of the waist (1.73±1.52)points, the VAS scores of the legs (1.59±0.67)points and the ODI scores (12.82±3.08)points were significantly lower than those before surgery(P<0.01). Postoperative pulmonary infection occurred in 1 case, deep wound infection in 1 case, and no complications such as progression of lumbar scoliosis, intervertebral space collapse, nerve injury and failure of the internal fixation system occurred. Conclusion　Posterior limited decompression, short segment fixation and fusion surgery are an effective method for treatment of lumbar degenerative scoliosis.]]> 2020/8/3 9:08:34 TANG Lin, LIANG Bin 61true ［Abstract］　Objective　To analyze the value of Breast Imaging and Reporting System Ultrasound(BI-RADS-US) rectified by ultrasound elastography in diagnosis of type 3 and type 4 breast lumps. Methods　Breast lumps of type 3 and type 4 diagnosed by conventional BI-RADS-US classification were diagnosed by ultrasound elastography as rectification. With the pathological results as the gold standard, the efficacies of BI-RADS-US classification were compared and analyzed in differential diagnosis of benign and malignant breast tumors before and after rectification. Results　The sensitivity, specificity and accuracy of the conventional BI-RADS-US classification were 75.6%, 88.1% and 83.8% respectively in diagnosis of benign and malignant breast tumors, and the area under the receiver operating characteristic(ROC) curve was 0.836. The sensitivity，specificity and accuracy of the BI-RADS-US classification with ultrasound elastography rectification were 82.9%, 93.1% and 90.8% respectively, and the area under ROC curve was 0.918. There were significant differences in the areas under ROC curve before and after rectification(P<0.05). Conclusion　Elastography is conducive to improving the diagnostic efficacies of ultrasound in the differential diagnosis of benign and malignant breast tumors of BI-RADS-US type 3 and type 4.]]> 2020/7/3 15:01:52 XI Jian-wu, ZHOU Yi-wei, YE Jian-qiang 60true ［Abstract］　Objective　To compare the application effects of drug-coated balloon(DCB) and drug-eluting stent(DES) on in-situ lesions of coronary arteries. Methods　A total of 110 patients with coronary heart disease treated with percutaneous coronary intervention(PCI) in the Department of Cardiology, the Fifth Affiliated Hospital of Zhengzhou University from July 2016 to July 2018 were selected as the study subjects,and were randomly divided into the DCB group(n=55) and the DES group(n=55) according to different treatment methods. The target lesion revascularization(TLR) rate, major adverse cardiovascular events(MACE), and quantitative coronary angiography(QCA) results were compared between the two groups 9 months after treatment. Results　There was no significant difference in the TLR rate between the two groups 9 months after PCI(P>0.05). The late lumen loss in the DCB group was less than that in the DES group, and the difference was statistically significant(P<0.05). Conclusion　DCB can reduce the late lumen loss and has no significant difference in TLR compared with DES, which has high application value for in-situ lesions of coronary arteries.]]> 2020/7/3 15:01:52 TONG Jing-huang, ZHANG Pei-sheng 59true ［Abstract］　Objective　To compare the efficacy and safety of partial nephrectomy with high selective renal artery occlusion via abdominal approach and retroperitoneal approach in treatment of stage T₁ renal carcinoma. Methods　Sixty-nine patients with renal carcinoma admitted to Luoyang Central Hospital Affiliated to Zhengzhou University from January 2015 to December 2018 were randomly divided into two groups among whom 33 patients underwent partial nephrectomy via abdominal approach(the abdominal approach group) and 36 patients underwent partial nephrectomy via retroperitoneal approach(the retroperitoneal approach group). The operation time, the amount of intraoperative blood loss, the postoperative creatinine recovery and the intestinal function recovery were compared between the two groups. Results　The operation time of the abdominal approach group was shorter than that of the retroperitoneal approach group(P<0.05). The recovery time of the intestinal function in the retroperitoneal approach group was shorter than that in the abdominal approach group(P<0.05) after surgery. There were no significant differences in the amount of intraoperative blood loss and the positive rate of the cutting edge between the two groups(P>0.05). Compared with those before operation, the serum creatinine changes were not significantly different after operation in both groups(P>0.05). Conclusion　Both approaches are safe and effective under the laparoscopic nephron-sparing surgery. The anatomic mark is clearer and the operation time is shorter through the abdominal approach. The postoperative recovery is quicker via the retroperitoneal approach.]]> 2020/7/3 15:01:52 WEI Peng-tao, MENG Qing-ting, ZHANG Han, et al. 58true ［Abstract］　Objective　To analyze the efficacy and safety of intravitreal ranibizumab(IVR) in treatment of macular edema(ME) associated with branch retinal vein occlusion(BRVO). Methods　The data of 66 patients with ME associated with BRVO who received IVR treatment in our hospital from May 2017 to May 2019 were retrospectively analyzed. According to the results of fundus fluorescein angiography(FFA), the patients were divided into ischemic BRVO(20 cases) group and nonischemic BRVO(46 cases) group. Ischemic BRVO diagnosis was made when the nonperfused area was greater than 5-disk area. When the nonperfused area was smaller than 5-disk area, the patients were diagnosed with nonischemic BRVO. Both groups were treated with 3+ prore nata(PRN) IVR. The best-corrected visual acuity(BCVA), the central macular thickness(CMT), the number of IVR injection and complications were compared between the two groups 1 month, 3 months and 6 months after treatment. Results　The BCVA was improved in both groups after treatment, and the BCVA after treatment was significantly different compared with that before treatment in the same group(P<0.05). However, there were no significant differences in the levels of BCVA between the two groups 1 month, 3 months and 6 months after treatment(P>0.05). After treatment, the levels of CMT in both groups showed a downward trend, and the level of CMT was significantly different compared with that in the same group before treatment(P<0.05). However, there were no significant differences in the levels of CMT between the two groups 1 month, 3 months and 6 months after treatment(P>0.05). The number of IVR injection was (4.17±0.93)times in the eyes with nonischemic BRVO group and (4.45±0.69)times in the ischemic BRVO, respectively, showing insignificant difference between the two groups(P>0.05). There were no IVR-related ocular or non-ocular complications in both groups. Conclusion　The 3+PRN IVR regimen is safe and effective in treatment of ME associated with BRVO.]]> 2020/7/3 15:01:52 WEN Mei-dan, HE Xiao-juan, YANG Fan 57true ［Abstract］　Objective　To investigate the effect of necrostatin-1(Nec-1), an inhibitor of receptor interacting protein-1/receptor interacting protein-3(RIP1/RIP3) signaling pathway, on peripheral neuropathic pain(NP). Methods　Thirty-six male Sprague-Dawley SD rats were randomly divided into blank control group(control group), spared nerve injury group(SNI group) and the intrathecal necrostatin-1 group(Nec-1 group), with 12 cases in each group. Nec-1 and SNI groups were intrathecally injected with nec-1(dissolved in dimethyl sulfoxide) and the same volume of dimethyl sulfoxide on the day 5 for a consecutive 5 days after establishing the model of SNI. Paw withdrawal mechanical threshold(PWMT) and paw withdrawal thermal latency(PWTL) were measured preoperatively and on day 1, 3, 5, 7, 10 and 14 postoperatively. On the 14th day, the rats were anesthetized and sacrificed for spinal dorsal horn sampling in L₄-L₆ sections. The levels of RIP1, RIP3 and mixed-lineage kinase domain-like protein(MLKL) were detected by Western blot, and the expression levels of pro-inflammatory factors of interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were detected by enzyme-linked immunosorbent assay(ELISA). Results　Compared with those in the SNI group, PWMT and PWTL in the Nec-1 group were significantly increased after intrathecal injection of necrostatin-1 on day 7, 10 and 14 postoperatively(P<0.05). Compared with those in the SNI group, the expressions of RIP1, RIP3 and MLKL proteins and the levels of IL-1β, TNF-α and IL-6 in the Nec-1 group were significantly reduced at the 14th day postoperatively(P<0.05). Conclusion　The inhibition of Nec-1 on necroptosis of spinal dorsal horn cells can effectively alleviate neuropathic pain through reducing the level of pro-inflammatory factors.]]> 2020/6/1 16:44:45 LUO Que-hua, CHANG Lu, LIU Ping-ping, et al. 56true ［Abstract］　Objective　To analyse the clinical effects of capecitabine maintenance therapy after first-line treatment on patients with advanced gastric cancer. Methods　Sixty-four stable advanced gastric cancer patients from February 2014 to February 2016 were retrospectively analyzed after a first-line chemotherapy(oxaliplatin 130 mg/m², d1+capecitabine 1 000 mg/m² bid, d1～14, 21 days as a cycle). According to the patients′ wishes, the patients were divided into the capecitabine maintenance treatment group(n=32, capecitabine 1 000 mg/m² bid, d1～14, 21 days as a cycle) and the control group(n=32, symptomatic support only). The differences in time to progression(TTP) and overall survival(OS) time between the two groups were tested by Kaplan-Meier method. The adverse reactions of capecitabine maintenance therapy were analyzed. Results　The median TTP was 7.6 months in the capecitabine maintenance treatment group and 6.0 months in the control group, with a significant difference between the two groups(P<0.05). The median OS was 11.9 months in the capecitabine maintenance treatment group and 9.5 months in the control group, with a significant difference between the two groups(P<0.05). The main adverse reactions of capecitabine were nausea and vomiting of 1～2 degrees, hand-foot syndrome, etc. Conclusion　Capecitabine monotherapy can prolong TTP and OS in patients with gastric cancer, with less toxic and side effects.]]> 2020/6/1 16:44:46 HU Xiao-dong, ZHANG Fang, WANG Jian 55true ［Abstract］　Objective　To investigate the causes of right ventricular outflow tract stenosis(RVOTS) complicated with pulmonary arterial hypertension(PAH) using echocardiographic technique. Methods　The preoperative echocardiographic images and clinical data of 8 patients with RVOTS and PAH proved by surgery in our hospital were retrospectively analyzed. Results　The possible causes of PAH included that arterial-level shunt in 3 cases, left heart diseases including aortic regurgitation and atrial fibrillation in 2 cases, and transient PAH in 1 case. There were multiple influencing factors in the other 2 cases,such as mismatch between ventricular septal defect(VSD) and RVOTS with arterial-level shunt, and VSD occurring after RVOTS, followed by left heart diseases of arterial-level shunt complicated with subaortic stenosis and aortic regurgitation. Conclusion　A few congenital heart disease patients have RVOTS complicated with PAH for many reasons. It is necessary to further analyze the causes of the disease to provide a reliable basis for the selection of clinical interventions.]]> 2020/6/1 16:44:46 LIU Na-di, HUANG Yun-zhou, LI Dong-bei, et al. 54true ［Abstract］　Objective　To analyze the imaging features of duodenal papillary adenocarcinoma examined by multi-slice computer tomography enterography(MSCTE), and to explore the diagnostic value of hypotonic MSCTE in duodenal papillary adenocarcinoma. Methods　The imaging features of 64 cases of duodenal papillary adenocarcinoma confirmed by pathology were retrospectively analyzed. Results　Of 64 patients, fifty-seven cases had smaller size of duodenal papillary adenocarcinoma(diameter≤3 cm), 7 cases with diameter 3.1～4.0 cm. But the changes of tumor morphology were quite different, including regular morphology in 47 cases and irregular morphology in 17 cases. 5 cases had liquefaction necrosis in larger tumors. The liquefaction necrosis area was clearly displayed in arterial and portal phases, and the boundary of delayed phase was blurred. 29 cases showed target sign in round nodules, not only in arterial phase, but also in portal phase and delayed phase. The target sign of lesions could be continuous or discontinuous at different levels. Of the 29 cases, 2 cases showed continuous target sign, and 27 cases showed discontinuous target sign. 59 cases showed soft tenuous dilatation of bile duct. 32 cases showed pancreatic duct dilatation, among whom 30 cases had simultaneous dilatation of pancreaticobiliary duct, and 2 cases had only dilatation of pancreatic duct. Among the 32 cases with pancreatic duct dilatation, 10 cases showed “multi-duct sign” of pancreatic head branch pancreatic duct dilatation, and clearly showed accessory pancreatic duct influx into accessory papilla. 3 cases had no dilatation of pancreaticobiliary duct. 27 cases had straight truncation of the lower end of common bile duct, and 14 cases had bird-bill-like stenosis, and 8 cases had cup-like filling defect when nodules protruded into the lumen. MSCTE preoperative judgement showed duodenal adenocarcinoma invading deep muscular layer and serosa layer of intestinal wall in 27 cases, invaded pancreas in 8 cases, lymph node metastasis in 6 cases, liver metastasis in 2 cases and concurrent gastric cancer and gallbladder cancer in 2 cases. Conclusion　MSCTE can improve the screening rate and diagnostic accuracy of duodenal papillary adenocarcinoma through its direct signs, dilatation of pancreaticobiliary duct and the display of its surrounding organs and tissues.]]> 2020/4/30 17:42:57 WANG Jia, WANG Yan, NIU Jun-qiao, et al. 53true ［Abstract］　Objective　To investigate the changes of serum adiponectin(APN) and insulin-like growth factor-1(IGF-1) levels in children with hand-foot-mouth disease(HFMD) and their clinical value. Methods　During March 2016 and December 2017, 114 children with HFMD were selected from Henan Children′s Hospital, including 53 cases in the general type group, 46 cases in the severe type group and 15 cases in the critical type group. The serum levels of APN and IGF-1 were detected at admission and 5 days after admission. Other 40 healthy children were selected as the control group. The serum levels of APN and IGF-1 were compared among the four groups. Results　The serum levels of APN and IGF-1 of HFMD patients in the severe type group and the critical type group were significantly lower than those in the general type group and the control group(P<0.05). On the 5th day after admission, the serum levels of APN and IGF-1 of the patients increased significantly. However, the levels of APN and IGF-1 in the severe type group and the critical type group were still lower than those in the general type group(P<0.05). Conclusion　Severe and critical HFMD children have obvious brain damage. The decrease of serum APN and IGF-1 levels is related to the severity of the disease, and is of guiding significance for the disease evaluation and the prediction of prognosis.]]> 2020/4/30 17:42:57 ZHU Lin, SONG Chun-lan, CUI Ya-jie, et al. 52true ［Abstract］　Objective　To explore the effects of puerarin on the invasion and migration of human hepatocellular carcinoma HepG2 cells and their related molecular mechanisms. Methods　The human hepatocellular carcinoma HepG2 cells were divided into two groups: experimental group and control group. The experimental group was cultured with puerarin of 60 μg/ml and 30 μg/ml, while the control group was cultured with medium added with equal volume of dimethyl sulfoxide(DMSO), a puerarin dissolving agent. The migration ability of the cells was detected in the two groups by cell scratch test, and the invasive ability was detected in the two groups by Transwell chamber. vimentin, epithelial cadherin(E-cadherin), matrix metalloproteinase 2/9(MMP2/9) were detected by Western blotting. Results　After the human hepatocellular carcinoma HepG2 cells were cultured with puerarin, the healing ability of cell scratches decreased; the invasive ability of Transwell chamber cells decreased; the expression of E-cadherin(P<0.05) increased; the expression of vimentin decreased(P<0.05);and the expressions of MMP2 and MMP9 were down-regulated(P<0.05). Conclusion　Puerarin reduces the invasion and metastasis of human hepatocellular carcinoma HepG2 cells by epithelial-mesenchymal transition(EMT).]]> 2020/4/30 17:42:57 WANG Hong-ming, WU Zhi-jun 51true ［Abstract］　Objective　To analyze the application value of prenatal echocardiography in late pregnant women. Methods　The data of prenatal echocardiography in 3 312 late pregnant women were selected in our hospital from January 2018 to June 2019 and were retrospectively analyzed. Results　Two hundred and eight cases(6.28%) were found abnormal by echocardiography, including 36 cases(1.09%) of structural heart defects and 172 cases(5.19%) of non-structural cardiac abnormalities, with the largest proportion of valve insufficiency. Conclusion　Prenatal echocardiography plays an important role in reducing the risk of adverse birth outcomes in late pregnant women.]]> 2020/4/30 17:42:57 YANG Fan, LIU Qing-chun, MEI Lan-lan 50true ［Abstract］　Objective　To observe the effect of dexmedetomidine combined with dezocine on patient-controlled epidural analgesia(PCEA) in patients with gynecological tumors after total hysterectomy. Methods　One hundred and twenty-three patients undergoing total hysterectomy were selected in our hospital from January 2016 to December 2017, and were divided into the dexmedetomidine group(group D, treated with dexmedetomidine 80 μg+ropivacaine 200 mg+dezocine 5 mg, normal saline added to 100 ml, intravenous drip, n=62) and the control group(group C, treated with ropivacaine 200 mg+dezocine 5 mg, normal saline added to 100 ml, intravenous drip, n=61). The anesthesia time, operation time and operation mode were compared between the two groups. When the patients were awake after surgery, the changes of Visual Analogue Score(VAS), Ramsay Sedation Score, pulse oxygen saturation(SpO₂), respiratory rate(RR), mean arterial pressure(MAP) and heart rate(HR) were observed at T₁(4 hours after operation), T₂(8 hours after operation), T₃(12 hours after operation) and T₄(24 hours after operation) in the patients of the two groups. The adverse reactions such as restlessness, nausea, vomiting, respiratory depression and pruritus were recorded, and the satisfaction degree of postoperative analgesia was also recorded. Results　There were significant differences in the Visual Analogue Scores and Ramsay Sedation Scores between the two groups, among different time points and the interaction between the groups and the time points(P<0.05). Compared with those in group C, the Visual Analogue Scores and Ramsay Sedation Scores in group D were significantly decreased at T₁, T₂, T₃ and T₄ after surgery(P<0.01). In general analysis, there were significant differences in HRs between the two groups in inter-group comparison, time-point comparison and interaction between the two groups and time points(P<0.05), while there were no significant differences in MAP, RR and SpO₂(P>0.05). The HR of group D was significantly lower than that of group C in the three time points of T₁, T₂ and T₃(P<0.01, P<0.01 and P=0.047). There were no cases with postoperative restlessness in group D, and there were 6 cases with postoperative restlessness in group C, with a significant difference between the two groups(P<0.05). In addition, the satisfaction degree of postoperative analgesia of the patients in group D(88.71%) was significantly higher than that in group C(59.02%)(P<0.01). Conclusion　Dexmedetomidine combined with dezocine provides better analgesic, effect and satisfaction after total hysterectomy in the patients with gynecological tumors, and reduces adverse reactions.]]> 2020/4/10 18:04:33 XING Hai-lin, XIANG Dong, LI Yun-xiang, et al. 49true ［Abstract］　Objective　To apply cone-beam computed tomography(CBCT) and Dolphin software for measuring the three-dimensional shape of the upper airway in adolescents of different genders, and provide a theoretical basis for clinical understanding of the three-dimensional shape of the upper airway in adolescents of different genders. Methods　Fifty-two patients(26 males and 26 females) with skeletal class Ⅲ and 52 patients(26 males and 26 females) with skeletal class Ⅰ were randomly selected from the Department of Orthodontics of Guiyang Hospital of Stomatology. CBCT was taken in all the patients. Dolphin software was used to measure the median sagittal plane hard palate plane(HP), the plane of the inferior margin of the soft palate(SP) and the sagittal diameter, coronal diameter and cross-sectional area of the epiglottis top plane(TE), and the volume of each section and the total volume. The differences of upper airway between male and female adolescents with skeletal class Ⅰ and those between male and female adolescents with skeletal class Ⅲ were compared. Results　A comparison of the upper airway measurement indexes was conducted between the male adolescents with skeletal class Ⅰ and the female adolescents with skeletal class Ⅰ, and the results showed that the sagittal diameter and coronal diameter of the glossopharyngeal segment and the volume of nasopharynx in the males were larger than those in the females, but there were no significant differences in the sagittal diameter, coronal diameter and cross-sectional area of the nasopharyngeal segment, and in the sagittal diameter, coronal diameter, cross-sectional area and volume of the palatine pharynx, and in the cross-sectional area, volume and total volume of the glossopharyngeal segment(P>0.05). There were no significant differences in the sagittal diameter, coronary diameter, cross-sectional area, volume of each segment and total volume of nasopharynx, palatopharyngeal and glossopharyngeal segments between the upper airway measurement indexes of the male adolescents with skeletal class Ⅲ and the female adolescents with skeletal class Ⅲ(P>0.05). Conclusion　The difference of upper airway between male adolescents with skeletal class Ⅲ and female adolescents with skeletal class Ⅲ should not be considered for the time being, which provides a certain clinical basis for simplifying the orthodontic treatment procedure. However, the difference of upper airway between male adolescents with skeletal class Ⅰ and female adolescents with skeletal class Ⅰ should be considered to make a reasonable treatment plan.]]> 2020/4/10 18:04:33 LIU Ying-ying, ZHENG Zhi-jun, LUO Chun-hua 48true ［Abstract］　Objective　To investigate the changing trend of prevalence rate of nosocomial infection and analyze its related factors to provide scientific basis for effective prevention and control of nosocomial infection. Methods　Cross-sectional survey method was used to investigate the prevalence rate of nosocomial infection among all the inpatients in a tertiary general hospital on a survey date during 2013 and 2018 year by year. Results　The prevalence rate of nosocomial infection during 2013 and 2018 year by year was 3.16%, 2.60%, 3.80%, 2.87%, 3.12% and 2.59% respectively, with no significant downward trend and no statistically significant difference in the trend of changes(χ²=0.456, P=0.499). The department with the highest incidence of nosocomial infection was the First Department of Critical Care Medicine(21.18%) and the main site of nosocomial infection was the lower respiratory tract(38.20%). The usage rate of antibacterial agents varied from 30.30% to 33.78% year by year during 2013 and 2018, and the difference of annualized rates was not statistically significant among the 6 years(χ²=6.823, P=0.234). The bacteria examination rate in the patients receiving therapeutic and therapeutic+prophylactic antibacterial agents was 72.07%. The results of multivariate analysis showed that age(≥ 65 years old)(OR=1.401, 95%CI: 1.098～1.788), use of ventilator(OR=3.533, 95%CI: 2.336～5.344), arteriovenous catheterization(OR=2.786, 95%CI: 2.116～3.668) and surgery(OR=3.555, 95%CI:2.837～4.455) were the independent risk factors of nosocomial infection. Conclusion　The prevalence rates of nosocomial infection in the hospital in the past six years show no significant trend of decline, but remain at a low level, and the overall situation of nosocomial infection control is good. It is necessary to strengthen the targeted monitoring of the Departments of Critical Care Medicine, the Department of Neurosurgery, Cardiothoracic Surgery and high-risk population, and formulate the control measures of hospital infection to reduce the incidence of hospital infection.]]> 2020/4/10 18:04:33 FAN Xue-jiao, LI Yuan-hui, XIE Pei-yan, et al. 47true ［Abstract］　Objective　To study the correlation between serum lipid levels and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods　A total of 152 inpatients with AECOPD were selected from March 2018 to March 2019. According to whether there was respiratory failure or not, the patients were divided into two groups: 62 cases in respiratory failure group and 90 cases in non-respiratory failure group. The patients in the respiratory failure group had type Ⅱ respiratory failure. The relevant indicators of the patients were detected and compared between the two groups, including total cholesterol(TC), triglyceride(TG), high-density lipoprotein(HDL-C), low-density lipoprotein(LDL-C), procalcitonin( PCT), interleukin-6(IL-6), C-reactive protein(CRP), arterial partial pressure of oxygen(PaO₂), arterial partial pressure of carbon dioxide(PaCO₂), forced expiratory volume in 1 second as a percentage of predicted value(FEV1/pred) and forced expiratory volume/forced vital capacity(FEV1/FVC) in the first second. Pearson correlation analysis was used to analyze the correlation between inflammatory factors, serum lipid levels and blood gas, lung function indicators, and the correlation between serum lipid levels and inflammatory factors. Results　The levels of serum inflammatory factors of PCT, IL-6 and CRP, and blood gas index PaCO₂ in the respiratory failure group were significantly higher than those in the non-respiratory failure group(P<0.01). The serum lipid levels of TC, TG and HDL-C, blood gas index PaO₂, lung function indexes FEV1/pred and FEV1/FVC in the respiratory failure group were significantly lower than those in the non-respiratory failure group(P<0.01). There was no significant difference in the change of LDL-C between the two groups(P>0.05). Pearson correlation analysis showed that PCT, IL-6 and CRP were significantly negatively correlated with PaO₂, FEV1/pred and FEV1/FVC in the AECOPD patients(P<0.001), and positively correlated with PaCO₂(P<0.001); TC, TG and HDL-C were positively correlated with PaO₂, FEV1/pred and FEV1/FVC(P<0.05), and negatively correlated with PaCO₂(P<0.05). The correlation between LDL-C and PaO₂, PaCO₂, FEV1/pred and FEV1/FVC was very low(P>0.05). TC, TG and HDL-C were significantly negatively correlated with PCT, IL-6 and CRP(P<0.001). The correlation between LDL-C and PCT, IL-6 and CRP was very low(P>0.05). Conclusion　The inflammatory factors are significantly increased, and the levels of serum lipids of TC, TG and HDL-C are significantly decreased in the AECOPD patients, and the levels of serum lipids are negatively correlated with inflammatory factors, suggesting that the changes of the serum lipids and inflammatory factors may reflect the severity of the disease.]]> 2020/4/10 18:04:33 LI Fang-fang, YUAN Xiao-yu, ZHANG Tie-shuan 46true ［Abstract］　Objective　To investigate the etiology and mechanism of trigeminal neuralgia caused by compression of complete denture. Methods　Cone-beam computed tomography was performed on 5 patients with trigeminal neuralgia caused by wearing complete dentures and the results showed that the alveolar ridge in the mental foramen area was completely absorbed and the mental foramen was exposed. The corresponding basal tissue surface of the mucosa in the mental foramen area was adjusted and ground, and the overlong edge of the dentures caused by alveolar ridge absorption in this area was removed. If the pain was not relieved, the dentures should be rebuilt and the mental foramen area should be fully cushioned. Results　Trigeminal neuralgia disappeared in 1 case after the second grinding of the denture. The symptoms disappeared in 2 cases after 5 times of grinding. The symptoms disappeared in 2 cases after the dentures were made again and the mental foramen area was fully buffered. Conclusion　After accelerated absorption of alveolar ridge of mandible, the mental foramen is exposed. The trigeminal nerve and its branches in the mental region are compressed by dentures, causing pain. After the pressure and stimulation in this area are relieved, the pain disappears.]]> 2020/4/10 18:04:33 LI Lu-lu, LI Wen, ZHANG Jian-mei 45true ［Abstract］　Objective　To investigate the clinical efficacy and safety of 27G transconjunctival sutureless vitrectomy for vitreous hemorrhage secondary to branch retinal vein occlusion(BRVO). Methods　The clinical data of 33 patients(33 eyes) with vitreous hemorrhage caused by BRVO who were treated with 27G vitrectomy were retrospectively analyzed. All the patients were followed up for 1 month after operation. The changes of best corrected visual acuity(BCVA) and intraocular pressure were compared before surgery, 1 week and 1 month after surgery. The clinical data of vitrectomy time, incision suture and leakage, intraoperative and postoperative complications were recorded. Results　The average time of vitrectomy was (16.30±4.10)minutes. The BCVAs were significantly improved 1 week and 1 month after surgery compared with those before surgery(P<0.01). The BCVA of one month after operation was higher than that of one week after operation(P<0.05). The mean IOP was (16.39±3.46)mmHg (1 mmHg=0.133 kPa), (15.37±2.32)mmHg and (16.69±2.45)mmHg before operation, 1 week after operation and 1 month after operation, respectively, and there was no significant difference between them(P>0.05). There was no need to suture the wound of the scleral puncture sites in all affected eyes after operation. The complications included iatrogenic retinal breaks in 1 eye, postoperative high intraocular pressure in 2 eyes and hypotony in 1 eye during the follow-up period. After reasonable treatment, the abnormal intraocular pressure returned to normal. No ocular or systemic adverse reactions were found in the other patients during the operation and postoperative follow-up. Conclusion　27G vitrectomy is safe and effective for vitreous hemorrhage secondary to BRVO with low rates of intraoperative and postoperative complications.]]> 2020/4/10 18:04:33 HAN Guang-jie, MO Xiong-jun, HUANG Hong-bo 44true ［Abstract］　Objective　To analyze the seasonal regularity of extended-spectrum β-lactamases(ESBLs) producing bacteria in Inner Mongolia Forestry General Hospital, and to provide scientific basis for the prevention and control of ESBLs producing bacteria. Methods　The seasonal trend of ESBLs producing bacteria from 2012 to 2017 was analyzed by using concentration and circular distribution methods. Results　The concentration of ESBLs producing bacteria in Inner Mongolia Forestry General Hospital was M=0.348. The peak date of detection of ESBLs producing bacteria in Inner Mongolia Forestry General Hospital was August 16 by using circular distribution method. The peak period of detection was 149 days, and the peak period was from June 2 to October 30. Conclusion　ESBLs producing bacteria in Inner Mongolia Forestry General Hospital have a seasonal trend, and the prevention and control of the bacteria infection should be strengthened to avoid nosocomial infection in that period.]]> 2020/3/16 15:42:27 SHI Yu, MU Jin-zhi, YIN Cui-xiang, et al. 43true ［Abstract］　Objective　To analyze the clinical characteristics and treatment of aluminum phosphide poisoning in children. Methods　The clinical data of 6 cases of aluminum phosphide poisoning diagnosed in our hospital from July 2015 to June 2018 were retrospectively analyzed. Results　Among the 6 cases, there were 4 males and 2 females, ranging in age from 1 year and 5 months to 10 years. All of the patients had vomiting and poor spirit. The older patients complained of dizziness. Two patients(both aged 1 year and 6 months, respectively) were complicated with heart failure. After admission, the patients received comprehensive treatments, 4 school-age children were discharged from the hospital after one week′s remission, and the family members of 2 infants gave up the treatment because all rescue measures proved ineffectual. Conclusion　The clinical manifestations of aluminum phosphide poisoning are not typical in children and the mortality of infants is high, and cardiovascular system damage is the main cause of death. At present, there are no special antidotes,so prevention is very important.]]> 2020/3/16 15:42:28 LI Guang-bo, LIU Cui-hua, TIAN Ming, et al. 42true ［Abstract］　Objective　To investigate the feasibility and safety of intraspinal analgesia with low-dose drugs for full-term vaginal delivery in re-pregnant women with genotype A118G-AA and previous cesarean section. Methods　Two hundred cases of re-pregnant women with previous cesarean section who voluntarily requested vaginal delivery in our hospital after 37 weeks of pregnancy were selected. According to the evaluation of the Outpatient Department of Obstetrics of our hospital, these 200 women had vaginal trial delivery conditions and voluntarily asked to take their venous blood sent to Berry Genomics for detecting genotype A118G-AA by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) Assay. The genotypes of the pregnant women were determined according to the base of OPRM1 exon 1 at site 118. A total of 62 cases of genotype AA(wild type) were selected for vaginal trial delivery. They were divided into the observation group(n=30) and the control group(n=32) according to different analgesic methods. The observation group was treated with low-dose intraspinal analgesia and the control group was given Doula instrument analgesia(music-guide analgesic instrument). The course of labor, the success rate of vaginal delivery, the delivery outcome and the maternal satisfaction after birth were analyzed and compared between the two groups. Results　The success rate of vaginal delivery in the observation group(86.7%) was significantly higher than that in the control group(59.4%)(P<0.05). The observation group was superior to the control group in terms of the first stage of labor, the perineal laceration degree, the Visual Analogue Scale score, the maternal satisfaction after birth and lactation initiation time(P<0.05). Conclusion　Intraspinal analgesia with low-dose drugs is safe and effective for full-term vaginal delivery in re-pregnant women with genotype A118G-AA and previous cesarean section. The analgesic effect of intraspinal analgesia with low-dose drugs is better than that of Doula instrument analgesia.]]> 2020/3/16 15:42:28 JIANG Hui 41true ［Abstract］　Objective　To investigate the best injecting dose for enhancement effect on rat liver by performing magnetic resonance enhanced scan for rat liver using different injection doses of manganese hexacyanoferrate nanoparticles, and analyze the relationship between injection doses and the degree of enhancement in the rat liver. Methods　Thirty-six healthy male SD rats were randomly divided into six groups, with 6 cases in each group. Different doses of manganese hexacyanoferrate nanoparticle were injected through the tail vein, and the doses were 20 μmol/kg, 25 μmol/kg, 30 μmol/kg, 50 μmol/kg, 80 μmol/kg and 150 μmol/kg body weight respectively. T1WI(TR=100 ms, TE=7.6 ms) sequence scanning was carried out before and after injection respectively. Single factor analysis of variance(ANOVA) was used to compare the signal-to-noise ratio(SNR) of the liver after enhancement of different doses of the contrast agent manganese hexacyanoferrate nanoparticle. The two-two comparisons among the means were done by LSD method. Results　After the doses of 20 μmol/kg, 25 μmol/kg, 30 μmol/kg and 50 μmol/kg body weight injection increased, the liver SNR increased in turn, and reached the peak at 50 μmol/kg. However, in the 80 μmol/kg and 150 μmol/kg groups, the liver SNR decreased. Conclusion　The liver SNR reaches the highest level at the dose of 50 μmol/kg of manganese hexacyanoferrate nanoparticle which is the best injection dose for enhancement effect in rat liver.]]> 2020/3/16 15:42:28 PAN Dong-mei, FAN Guo-hua 40true ［Abstract］　Objective　To analyze the clinical curative effects of transurethral plasmakinetic enucleation and resection of prostate(PKERP) and plasmakinetic resection of prostate(PKRP) in treatment of benign prostatic hyperplasia(BPH) and their influences on the patients′ sexual function after operation. Methods　Eighty BPH patients treated from January 2017 to February 2019 were randomly divided into PKRP group and PKERP group, with 40 cases in each group. Both groups received the same basic treatment regimen. The PKERP group received PKERP procedure and the PKRP group received PKRP procedure. The postoperative bladder irrigation time and urinary catheter indwelling time was compared between the two groups. The International Prostate Symptom Score(IPSS), the International Index of Erectile Function(IIEF-5) Score, the level of serum high-sensitivity C-reactive protein(hs-CRP), the bladder residual urine volume and the curative effect were compared between the two groups before and 3 months after surgery. Results　The postoperative bladder irrigation time of the patients in the PKERP group was significantly shorter than that in the PKRP group(P<0.01). The urinary catheter indwelling time of the patients in the PKERP group was significantly shorter than that in the PKRP group(P<0.01). The IPSS of the patients in the PKERP group was significantly lower than that in the PKRP group(P<0.01). The IIEF-5 score of the patients in the PKERP group was significantly higher than that in the PKRP group(P<0.01). The level of serum hs-CRP of the patients in the PKERP group was significantly lower than that in the PKRP group(P<0.01). The bladder residual urine volume of the patients in the PKERP group was significantly less than that in the PKRP group(P<0.01). In the PKERP group, 8 cases were cured, 21 cases markedly effective, 10 cases effective and 1 case ineffective. In the PKRP group, 7 cases were cured, 11 cases markedly effective, 16 cases effective and 6 cases ineffective. The curative effect of the PKERP group was better than that of the PKRP group(P<0.05). Conclusion　PKERP is effective for the patients with BPH, with a quick recovery after operation and less impact on the sexual function of the patients. Compared with PKRP, PKERP has obvious advantages.]]> 2020/3/16 15:42:28 HUANG Jun, SUN Ming 39true ［Abstract］　Objective　To analyze the clinical effects of closed reduction of Garden Ⅰ, Ⅱ and Ⅲ fractures of the femoral neck treated by two cannulated screws internal fixation. Methods　Eighty-five cases of femoral neck fractures which were fresh non-pathological femoral neck fractures were collected in our hospital from January 2013 to August 2017. Garden was classified as type Ⅰ, Ⅱ and Ⅲ. 45 cases releived two cannulated screws internal fixation(three-screw group): 18 cases of Garden type Ⅰ, 11 cases of type Ⅱ, and 16 cases of type Ⅲ. 40 cases releived 3 cannulated screws internal fixation(two-screw group): 13 cases of Garden type Ⅰ, 9 cases of type Ⅱ, and 18 cases of type Ⅲ. At the same time, related clinical data were collectied, and 85 cases were followed up for 12～24 months, with an average of (20.26±2.68)months. The fracture healing and necrosis of the femoral head were evaluated, and Harris score of hip joint function was used to evaluate the clinical effects after operation. Results　In the 45 cases who were fixed with two cannulated screws, 42 cases were healed with a healing rate of 93.33%, among whom the internal fixation nails were removed in 15 cases due to bone healing and necrosis of femoral head occurred in 3 cases. In the 40 cases who were fixed with 3 cannulated screws, 38 cases were healed with a healing rate of 95.00%, among whom necrosis of femoral head occurred in 2 cases. There was no significant difference in the healing rate between the two groups(P>0.05). In the 45 cases who were fixed with two cannulated screws, all the patients had an average of Harris score of hip joint function being (89.70±8.82)points, 36 cases were excellent, 4 cases good, 2 cases fair and 3 cases poor, with an excellent and good rate of 88.89%. In the 40 cases who were fixed with 3 cannulated screws, all the patients had an average of Harris score of hip joint function being (91.53±8.38)points, 35 cases were excellent, 2 cases good, 1 case fair and 2 cases poor, with an excellent and good rate of 92.50%. There were no significant differences in Harris score and excellent and good rate between the two groups(P>0.05). Conclusion　Two cannulated screws internal fixation is clinically effective in treatment of closed reduction of Garden Ⅰ, Ⅱ and Ⅲ fractures of the femoral neck.]]> 2020/3/16 15:42:28 YI Bo-de, LIANG Bin 38true ［Abstract］　Objective　To compare the effects of transabdominal preperitoneal prosthetic(TAPP) and Lichtenstein hernia repair on coagulation function in patients with inguinal hernia. Methods　Seventy patients with inguinal hernia admitted to our hospital from June 2017 to June 2019 were selected, and were randomly divided into study group and control group, with 35 cases in each group. The study group was treated with TAPP, while the control group was treated with Lichtenstein hernia repair. The operation results and the changes of coagulation function indicators were observed and compared between the two groups. Results　There were no significant differences in prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(Fbg)and D-dimer(D-D)between the two groups before surgery(P>0.05). Compared with those before surgery, PT and APTT decreased significantly while Fbg and D-D levels increased significantly in the two groups 0 h and 24 hours after surgery(P<0.05). There were no significant differences in PT, APTT and Fbg between the two groups 0 h and 24 hours after surgery(P>0.05). There was a significant difference in D-D level between the two groups after surgery(P<0.05). However, there was no significant difference in D-D level between the two groups 24 hours after surgery(P>0.05). The fluctuation of D-D level was greater in the study group after operation, which showed a higher increase after operation and a more decrease 24 hours after operation(P<0.05). Conclusion　Both TAPP and Lichtenstein hernia repair can enhance the coagulation function of the patients with inguinal hernia, and keep blood in a hypercoagulable state. Although TAPP may bring hypercoagulable state to the patients, it does not increase the risk of deep vein thrombosisc(DVT) after operation because of quick recovery and early movement in the patients receiving TAPP. TAPP is worthy of clinical application.]]> 2020/2/18 17:19:02 XU Hao, ZHENG Lun-hui, ZHANG Ju-yi, et al. 37true ［Abstract］　Objective　To summarize the application value and difference of brain color Doppler ultrasound and magnetic resonance imaging(MRI) in diagnosis of neonatal intracranial diseases by analyzing the results of brain color Doppler ultrasound of high-risk term infants born in our hospital and comparing the results of brain ultrasound and MRI of the abnormal ones. Methods　The clinical data of 355 high-risk term infants born in the hospital from January 2017 to January 2019, and the results of the brain ultrasound and MRI examination within 7 days of birth were collected. Results　There were 85 cases(23.9%) with positive brain lesions, among them 66 cases(18.6%) with subependymal cyst diagnosed by brain ultrasound, and compared with 44 cases(12.4%) of MRI, the difference was statistically significant(P<0.05). The results of intraventricular hemorrhage detected by craniocerebral ultrasound were similar to those detected by MRI, and the difference was not statistically significant(P>0.05). The positive rates of hypoxic-ischemic encephalopathy, cerebellar lesions and subarachnoid hemorrhage diagnosed by MRI were higher than those diagnosed by craniocerebral ultrasound. Among the three diseases, the sensitivity of MRI in diagnosis of subarachnoid hemorrhage was significantly higher than that of craniocerebral ultrasound(P<0.05). Conclusion　Doppler ultrasound is safe and repeatable. It can accurately diagnose intracranial hemorrhage, subependymal cyst, hypoxic-ischemic encephalopathy and other common intracranial diseases of newborns. However, the resolution of the lesions in the edge of brain and posterior cranial fossa is poor.]]> 2020/2/18 17:19:02 CHENG Yuan, DENG Wei, HUANG Xiang-hui 36true ［Abstract］　Objective　To observe the clinical efficacy of oral Traditional Chinese Medicine(TCM) combined with ginger moxibustion for treatment of Helicobacter pylori(Hp)-positive chronic atrophic gastritis(CAG) accompanied with intestinal metaplasia. Methods　Ninety-two patients were randomly divided into observation group and control group by SAS software, with 46 cases in each group. The two groups were given routine treatment of tincture quadruple eradication. The control group received folic acid treatment on the basis of the routine treatment and the observation group was given oral TCM and ginger moxibustion plus the same routine treatment as the control group. Both of the two groups were treated continuously for 12 weeks. The TCM syndrome scores, the levels of serum pepsinogen (PG)Ⅰ, PGⅡ, PGR(PGⅠ/PGⅡ) and gastrin-17(G-17) were observed in the two groups before and after treatment. The patients were reexamined by gastroscopy and the reexamination of Hp was performed one month after treatment in both groups, and their clinical effects were compared. Results　The total clinical effective rate of the observation group was 91.30%, and the negative rate of Hp was 93.48%, which was significantly better than those of the control group(P<0.05). The TCM syndrome scores, gastric mucosal inflammation, gland atrophy and intestinal metastasis scores were obviously decreased, and the levels of serum PGⅠ, PGR ratio and G-17 were increased, the level of PGⅡ of the two groups after treatment was significantly lower than those before treatment and the improvement of the observation group was better than that of the control group(P<0.05). There were no obvious adverse reactions in the two groups. Conclusion　Oral TCM combined with ginger moxibustion is effective in treatment of CAG accompanied with intestinal metaplasia, which can effectively improve the clinical symptoms, reduce the inflammatory reaction, protect the gastric mucosa, improve the gastric mucosal atrophy and intestinal metaplasia, and promote Hp to turn negative. The combination therapy is safe and reliable and is worthy of further clinical research.]]> 2020/2/18 17:19:02 JIANG Rui, YUAN Xiang-ke 35true ［Abstract］　Objective　To analyze the clinical effect of percutaneous vertebroplasty(PVP) on osteoporotic vertebral compression fractures(OVCF). Methods　One hundred and fifty-eight patients(205 vertebrae) treated with PVP due to OVCF were selected in our hospital from January 2017 to January 2018. The visual analogue score(VAS), the oswestry disability index(ODI) scores, the height of the anterior edge of the injured vertebrae and the Changes of Cobb angles were compared before and after operation to evaluate the therapeutic effects. The relationship between the clinical effect and the injection volume of bone cement was analyzed. Results　The VAS scores and the ODI scores of all the patients after operation were significantly lower than those before operation(P<0.05). The height of the anterior edge of the injured vertebrae and the Cobb angle were significantly recovered after operation(P<0.05). Conclusion　PVP has a good clinical effect on OVCF, which can relieve pain as early as possible, and improve the quality of life of the patients.]]> 2020/2/18 17:19:02 LIU Gang, SHI Zhan-ying, PENG Xiao-zhong, et al. 34true ［Abstract］　Objective　To investigate the epidemiological and clinical characteristics of a 2019 corona virus disease(COVID-19) family cluster, so as to provide evidence for further prevention and control efforts. Methods　(1)Epidemiological investigation: all the information of exposure histories, family clusters, and medical/home isolation was collected through telephone and face-to-face interviews with the patients, family members, and other informed persons(medical personnel). (2)Clinical data collection: the patients′ general condition, clinical symptoms, signs, laboratory examinations, imaging results, treatment planes, disease outcomes and short-term prognoses were collected by consulting the medical records and inquiring the medical history of the patients and their family members. Results　(1)There were 11 confirmed COVID-19 cases in the family, with the epidemiological characteristics of living together in close direct or indirect contact with the COVID-19 index cases confirmed in the epidemic area of Wuhan. (2)None of the 11 confirmed cases of COVID-19 had severe symptoms, and the clinical manifestations of the children were mild and atypical. (3)After treatment, severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) nucleic acid was retested to be positive in 4 COVID-19 patients who were discharged from the hospital because of meeting discharge criteria, of whom, 1 adult had mild symptoms and 3 children had no symptoms. Conclusion　(1)Clustering is an important epidemic feature of this outbreak, and close family contact is the main form of COVID-19 infection in children. (2)The positive results of SARS-CoV-2 nucleic acid retest after discharge can not be used to assess the severity of the disease.]]> 2020/12/31 0:00:00 WEN Zhi-hong, TANG Hui-he,WANG Bang-qin, et al. 33true ［Abstract］　Objective　To investigate the clinicopathological features, diagnosis and differential diagnosis of leiomyomatosis peritonealis disseminata(LPD). Methods　The clinicopathological features, histological morphology and immunophenotype of 4 patients with LPD were retrospectively analyzed and the relevant literatures were reviewed. Results　All of the 4 cases were female, aged 32～51 years. Microscopy: The tumors were consisted of relatively uniform spindle cells in an interlacing arrangement, cytoplasmic red staining, rod-shaped nuclei and rare mitosis. Immunophenotype: The tumor cells expressed smooth muscle actin(SMA), desmin and Ki-67, while CD117, CD34, S-100 and DOG-1 were all negative. Conclusion　LPD is a rare benign tumor with a good prognosis. Its diagnosis mainly depends on its histopathological characteristics and immunophenotype.]]> 2020/12/31 15:05:24 WU Ying-ying, DING Li, YANG Rui-xue, et al. 32true ［Abstract］　Objective　To compare the therapeutic effects of catheter-directed thrombolysis(CDT) and AngioJet Device in acute deep venous thrombosis of lower extremity. Methods　The clinical data of 34 patients with acute deep venous thrombosis of lower extremity treated with interventional surgery in the Department of Vascular Surgery of the Second Affiliated Hospital of Anhui Medical University from January 2018 to November 2019 were retrospectively analyzed, among whom 18 cases received CDT treatment(CDT group) and 16 cases received AngioJet Device treatment(AngioJet group). The preoperative and postoperative D-dimer(D-D) values and fibrinogen(Fib) values, the postoperative thrombus removal rate and lower extremity detumescence rate were compared between the patients in the two groups. Results　All the 34 patients completed the operation successfully. The postoperative immediate thrombus removal rate and the detumescence rate in the CDT group were lower than those in the AngioJet group, and the differences were significant between the two groups(P<0.05). The postoperative peak value of D-D and the dosage of urokinase in the CDT group were higher than those in the AngioJet group, and the differences were significant between the two groups(P<0.05). Conclusion　AngioJet Device has higher thrombus removal rate and safety in the treatment of acute deep venous thrombosis of lower extremity, which has certain significance to guide clinical application.]]> 2020/12/5 15:52:01 LIU Yue-qiu, WAN Sheng-yun 31true ［Abstract］　Objective　To analyze the safety and effectiveness of endoluminal minimally invasive surgery for ureteral calculi complicated with distal ureteral stricture. Methods　The clinical data of 50 patients with ureteral calculi complicated with distal ureteral stricture admitted to the Department of Urology, Changzhou Wujin People′s Hospital from January 2014 to November 2019 were retrospectively analyzed. The diagnosis of ureteral calculi was confirmed by the improved relevant examinations before operation. Rigid ureteroscopy was used. During the operation, it was found that the ureteroscopy could not be carried out due to distal ureteral stricture, and COOK ureteral dilator was used for ureteral stricture expansion and the operation was successfully completed. If the ureteral stricture was serious and ureteral dilatation was unsuccessful, double J tube was placed and two-stage ureteroscopy or flexible ureteroscopy was performed. The patients were reexamined 3 months after the operation, and B-ultrasonography and intravenous pyelography were performed to evaluate the clearance of the calculi and the patency of ureters. Results　Thirty-six cases(72.0%) of the 50 patients were successfully treated with rigid ureteroscopic lithotripsy in one stage after ureteral stricture was dilated with COOK ureteral dilator. COOK ureteral dilator failed to dilate the ureteral stricture for the remaining 14 patients and the ureteroscope could not be inserted, and double J tubes were placed. According to the degree of ureteral stricture, two-stage endoluminal minimally invasive surgery was performed 2 weeks to 2 months later. Among them, ureteroscopic pneumatic lithotripsy was successfully performed on 7 cases; flexible ureteroscope holmium laser lithotripsy was successfully performed on 5 cases, and 2 patients underwent ureteroscopy at the second stage and the stones were found to have passed out of the body by itself. Conclusion　Ureteroscopic lithotripsy in one stage after dilation of ureteral stricture using COOK ureteral dilator can be used for ureteral calculi complicated with distal ureteral stricture. If the ureteral stricture is serious and the ureteral dilatation is still difficult to access, double J tube is placed and two-stage endoluminal minimally invasive lithotripsy is performed, which is a safe and effective method of minimally invasive treatment.]]> 2020/12/5 15:52:01 WEI Han-ping, JIAO Zhi-min, YUAN Xiao-liang, et al. 30true ［Abstract］　Objective　To analyze the clinical characteristics of acute bilirubin encephalopathy(ABE) in neonates. Methods　The clinical data of 92 cases of neonatal bilirubin encephalopathy with gestational age≥35 weeks from January 2015 to December 2017 in four hospitals in Henan Province were collected and analyzed retrospectively. Results　In the 92 cases, the median age of admission was 5.0 days; the median age of occurrence of jaundice was 2.1 days, and the median time of diagnosis of bilirubin encephalopathy was 4.0 days. In primary diseases, there were 53 cases of hemolytic disease(57.6%), 36 cases of sepsis or infection(39.1%), 2 cases of birth-related traumatic disease(2.2%), 1 case with no primary disease found and considered to be related to improper feeding. The mean peak level of total bilirubin(TBiL) was (522.63 ± 120.64)μmol/L; albumin was (33.73±4.29)g/L, and TBiL/serum allbumin(B/A) was (9.21±2.24)mg/g. Brainstem auditory evoked potential(BAEP) examination was completed in 71 cases among whom 22 cases were normal, and 8 cases were mildly to moderately abnormal, and 41 cases were severely abnormal, and the abnormal rate was 69.0%. Cerebral magnetic resonance imaging(MRI) examination was completed in 69 cases among whom 32 cases were found having the typical changes of ABE(46.4%). Mechanical ventilation was performed in 21 cases, phototherapy in 92 cases, exchange transfusion in 84 cases, intravenous injection of immunoglobulin in 57 cases, intravenous injection of albumin in 76 cases and enzyme inducer in 36 cases. There were 21 deaths. Among the 71 patients who survived, 39 cases(54.9%) had severe neurological dysfunction such as residual hearing and cerebral palsy. The average TBiL peak value in the death group was (568.04±103.63)μmol/L, but there was no significant difference between the death group and the survival group (511.28±123.36)μmol/L(P>0.05). Conclusion　Neonatal ABE is easy to cause residual hearing impairment. The duration and intensity of phototherapy, whether or not it is performed simultaneously with exchange transfusion, is necessary.]]> 2020/12/5 15:52:01 LI Rui, FU Hui, LI De-liang, et al. 29true ［Abstract］　Objective　To explore the relationship between a disintegrin and metalloproteinase with thrombospondin motifs 7(ADAMTS7) gene expression level and the prognosis and clinical characteristics of glioma patients. Methods　 Two transcriptome sequencing data sets, mRNAseq 693 and mRNAseq 325, were downloaded from Chinese Glioma Genome Atlas(CGGA) Database(http://www.cgga.org.cn). The mRNAseq 693 was used as an exploration data set, and the mRNAseq 325 as a validation data set. The ADAMTS7 gene expressions of the data set cases were extracted, and the median value of ADAMTS7 was used as the cutoff threshold to divide the patients into high expression group and low expression group. The relationship between ADAMTS7 gene expression level and the clinicopathological characteristics of the patients and its impact on the patients′ survival prognosis were analyzed. The Cancer Genome Atlas(TCGA) glioma cohort was used as an external data set to verify the relationship between ADAMTS7 gene expression level and the prognosis of glioma patients. Results　Whether in the exploration data set or in the validation data set, the differences between the ADAMTS7 gene high expression group and the low expression group were statistically significant in terms of occurrence status, histological type, World Health Organization(WHO) classification, chemotherapy status, isocitrate dehydrogenase(IDH) mutation status, and chromosome 1 short arm and chromosome 19 long arm(1p19q) co-deletion status(P<0.05). For the exploration data set, the results of multivariate Cox regression analysis showed that higher level of ADAMTS7 gene expression, disease recurrence, WHO grade Ⅳ and age >43 years were the risk factors for survival prognosis of the patients, while receiving chemotherapy, IDH mutation and 1p19q co-deletion were the protective factors for postoperative prognosis of the patients(P<0.05). For the validation data set, the results of multivariate Cox regression analysis showed that higher ADAMTS7 gene expression level, disease recurrence, and WHO classification of grade Ⅳ were the risk factors for survival prognosis of the patients, while the histological type of glioblastoma(GBM), receiving chemotherapy and 1p19q co-deletion were the protective factors for the patients′ postoperative survival prognosis(P<0.05). The results of Kaplan-Meier survival analysis showed that, whether in the exploration data set or in the validation data set, the survival prognosis of the ADAMTS7 gene low expression group was significantly better than that of the high expression group(P<0.001). Using TCGA glioma data as an external data set, the results showed that the overall survival(OS) and progression-free interval(PFI) of the ADAMTS7 gene high expression group were better than those of the low expression group, and the differences were statistically significant(P<0.001). Conclusion　ADAMTS7 gene expression level can be used as a predictor for evaluating the prognosis of glioma patients, and has potential clinical application value.]]> 2020/11/3 8:38:30 ZHUANG Sheng, YANG Si-jie, HE Li-huan, et al. 28true ［Abstract］　Objective　To introduce the surgical technique of laparoscopic pancreatic segmental resection(LPSR), and to analyze its safety, feasibility and efficacy. Methods　The clinical data of 1 case of laparoscopic duodenum-preserving pancreatic head resection(LDPPHR), 1 case of laparoscopic central pancreatectomy(LCP) and 1 case of laparoscopic spleen-preserving distal pancreatectomy(LSPDP) in the Department of Hepatobiliary, Pancreatic and Splentic Surgery, the People′s Hospital of Guangxi Zhuang Autonomous Region from March 2017 to October 2017 were introduced and analyzed. Results　Total laparoscopic surgery was successfully completed in all the 3 patients. The operation time of LDPPHR, LCP and LSPDP was 409 min, 486 min and 251 min, respectively. The blood loss during the periods of LDPPHR, LCP and LSPDP was 150 ml, 200 ml and 200 ml, respectively. During the follow-up of 31～39 months, there were no deficiencies pancreatic endocrine and exocrine function and no tumor recurrence. Conclusion　Laparoscopic pancreatic segmental resection is technically safe, feasible and repeatable. It is a surgical method with less invasion and greater protection of organ function, and its curative effect is satisfactory, but it needs to be performed by skilled surgical teams in experienced clinical centers.]]> 2020/11/3 8:38:30 LIANG Bin, CHEN Yuan-yuan, DONG Xiao-feng, et al. 27true ［Abstract］　Objective　To analyze the clinicopathological characteristics of ovarian mixed germ cell tumors(OMGCT), and to investigate the missed diagnosis and misdiagnosis of tumor components and their causes. Methods　The case data of 36 patients diagnosed with OMGCT were collected, and morphological observation and immunohistochemical examination were performed. Results　The onset age of the 36 patients was 6～63 years, with a median age of 22.4 years. All the tumors contained two or more tumor components of germ cell tumors. Among them, 13 cases missed the diagnosis of yolk sac tumor component; 2 cases missed the diagnosis of dysgerminoma component; 1 case missed the diagnosis of choriocarcinoma component, and the missed diagnosis rate was 44.4%. One case was misdiagnosed with clear cell carcinoma. Conclusion　Ovarian mixed germ cell tumors often have a mixture of multiple tumor components with different proportions and growth patterns. Different types of germ cell tumors have different treatments and prognoses.]]> 2020/11/3 8:38:30 LIU Wei, ZHANG Li-hong, QU Yu-qing, et al. 26true ［Abstract］　Objective　To investigate the efficacy of neoadjuvant endocrine therapy for hormone receptor positive/HER2-negative(HR⁺/HER2^-) breast cancer. Methods　The clinical and pathological related data of 40 patients with HR⁺/HER2^- breast cancer who received neoadjuvant endocrine therapy and surgery from July 2018 to July 2020 were retrospectively analyzed. The patients were divided into the observation group(receiving neoadjuvant endocrine therapy) and the control group(receiving neoadjuvant chemotherapy) according to different treatment methods, with 20 cases in each group. The observation group was treated with letrozole or tamoxifen, 28 days as a cycle, for a total of 4-6 cycles, and the patients with no progress continued to take medicine until 24 weeks, and the patients were scheduled for surgery. The control group underwent surgery after 8 cycles of epirubicin+cyclophosphamide sequential docetaxel(EC-T) chemotherapy. The clinical efficacy, Ki-67 changes, serum carbohydrate antigen 153(CA153) changes, preoperative endocrine prognostic index(PEPI) score, and toxicity and side effects were compared between the two groups. Results　The difference in objective remission rate was not significant between the two group(P>0.05). The decrease rate of Ki-67 in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05). Compared with that before treatment, the serum CA153 content in the observation group decreased significantly after treatment, and the difference was statistically significant(P<0. 05). The rate of high risk of PEPI score in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The rate of toxicity and side effects in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion　Neoadjuvant endocrine therapy and neoadjuvant chemotherapy have similar efficacy in patients with HR⁺/HER2^- breast cancer, but the safety of neoadjuvant endocrine therapy is better than that of neoadjuvant chemotherapy.]]> 2021/8/6 11:16:11 ZHENG Tao, WANG Geng 25true ［Abstract］　Objective　To analyze the correlation between the level of lipoprotein-associated phospholipase A2(Lp-PLA2) in blood and arteriosclerosis obliterans(ASO) of lower extremity. Methods　A total of 108 patients diagnosed probably with ASO in the Second Affiliated Hospital of Zhengzhou University from November 2018 to January 2019 were selected as the study subjects, and were divided into non-ASO group(the control group, 32 cases) and ASO group(the study group, 76 cases) according to the results of ankle-brachial index(ABI). The baseline data and laboratory data were collected from the two groups, and computed tomography angiography(CTA) of the arteries of the lower limbs was performed on the study group. Binary logistic regression was used to analyze the factors influencing the occurrence of ASO. Fontaine staging was performed on the study group. The severity of Trans-Atlantic Inter-Society Consensus Ⅱ(TASCⅡ) was graded according to the CTA results. The correlation between plasma Lp-PLA2 level and the severity of lower limb occlusion in the study group was analyzed. Results　Male, age and the rate of having a history of smoking in the study group were significantly higher than those in the control group(P<0.05). The levels of plasma Lp-PLA2 in plasma and homocysteine(Hcy) in the study group were higher than those in the control group, and the differences were significant(P<0.05). Logistic regression analysis showed that high age(OR=1.139, 95%CI: 1.036～1.252) and high level of plasma Lp-PLA2(OR=1.025, 95%CI: 1.010～1.040) were the risk factors for ASO. Correlation analysis showed that the level of plasma Lp-PLA2 in the study group was positively correlated with the severity of ASO(P<0.05). Conclusion　Plasma Lp-PLA2 in plasma is a risk factor affecting the occurrence of ASO, and the degree of arteriosclerosis occlusion of lower extremity increases with the increase of plasma concentration of plasma Lp-PLA2. Lp-PLA2 in plasma can be used as an early detection index for ASO evaluation.]]> 2021/8/6 11:16:11 MUNIRE Yuemaier, ZHOU Zhi-qiang, ZHOU You-xu, et al. 24true ［Abstract］　Objective　To explore the expression of tumor-associated antigen melanoma-associated antigen family member D4(MAGE-D4) in hepatocellular carcinoma(HCC) and to analyze its clinical significance. Methods　Based on the cancer genome atlas(TCGA) database, the transcription data of 371 cases of HCC tissues and 50 cases of normal liver tissues were obtained. The data mining tool UALCAN was used to analyze the expression of MAGE-D4 mRNA in HCC tissues, and to screen the genes related to the MAGE-D4 mRNA expression. Kaplan-Meier Plotter was used to analyze the relationship between MAGE-D4 mRNA expression level and the patients′ survival prognosis. In addition, 70 HCC specimens and 30 paracancerous tissue specimens were collected from the First Affiliated Hospital of Guangxi Medical University during June 2009 and August 2011. The expression of MAGE-D4 protein was detected by immunohistochemistry(IHC), and the correlation between the expression of MAGE-D4 protein and the patients′ clinical indicators was analyzed. Results　The data analysis based on the TCGA database showed that the expression level of MAGE-D4 mRNA in the HCC tissues was significantly higher than that in the normal liver tissues(P<0.05), and was positively correlated with alpha fetoprotein(AFP) mRNA expression(r=0.556, P=0.000). The results of survival analysis showed that the high expression of MAGE-D4 mRNA was significantly associated with the poor survival prognosis of yellow race HCC patients(HR=1.860, P=0.037). The analysis results based on the clinical specimens showed that MAGE-D4 protein was mainly located in the cytoplasm and nucleus, and the high expression rate of MAGE-D4 in the HCC tissues was significantly higher than that in the adjacent tissues(48.57% vs 23.33%; χ²=5.530, P=0.019). The proportion of HCC patients with serum AFP concentration ≥400 μg/L in MAGE-D4 high expression group was significantly greater than that in low expression group(P<0.05), but there was no statistically significant difference between the two group in gender, age, tumor grade, tumor stage, tumor diameter, tumor thrombus and hepatitis B virus(HBV) infection(P>0.05). Conclusion　MAGE-D4 is highly expressed in HCC tissues, which may play an important role in the occurrence and development of HCC, and is expected to become a potential therapeutic target and a prognostic marker for HCC.]]> 2021/7/5 12:12:34 LUO Xin, SHEN Ning, LIU Chang, et al. 23true ［Abstract］　Objective　To construct a competing endogenous RNAs(ceRNA) regulatory network for chromophobe renal cell carcinoma(CRCC), and to screen out messenger RNA(mRNA), long non-coding RNA(lncRNA) and micro RNA(miRNA) related to the prognosis of CRCC, so as to provide a theoretical basis for the diagnosis and prognosis of CRCC. Methods　The transcriptome data of CRCC samples(65 cases) and normal kidney specimens(24 cases) were extracted from the Cancer Genome Atlas(TCGA) database, and the differentially expressed(DE) lncRNA, miRNA and mRNA were screened under the condition of false discovery rate(FDR)<0.05 and absolute logarithm of fold change(log₂|FC|)>2. Based on these, the ceRNA regulatory network was constructed. The Kaplan-Meier method was used to explore the factors related to the prognosis of CRCC patients, and based on this, the protein-protein interaction(PPI) network was further constructed, and Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis was performed. Results　A total of 3 679 DElncRNA, 297 DEmiRNA and 5 914 DEmRNA were screened.The down-regulated mRNA ceRNA network contained 95 DEmiRNA, 268 DEmRNA, and 737 DElncRNA; the up-regulated mRNA ceRNA network contained 85 DEmiRNA, 234 DEmRNA, and 924 DElncRNA. Kaplan-Meier analysis screened out 3 DEmRNAs(DEPDC1, SLC7A11 and E2F7) and 1 DEmiRNA(miR-26b-5p), which were associated with the prognosis of CRCC(P<0.05). The PPI network constructed with DEPDC1, SLC7A11 and E2F7 contained a total of 8 mRNAs(TOP2A, DEPDC1, SLC3A2, E2F8, SLC7A11, E2F1, TP53 and E2F7) that participated in protein interactions. The enrichment analysis of GO and KEGG showed that these interaction proteins function mainly enriched in DNA damage response, p53-mediated cell tissue and promoter specific binding, iron death, and tumor-associated signal pathways. Conclusion　In this study, the key RNAs related to CRCC prognosis are screened out by constructing the ceRNA regulatory network of CRCC, which provides a theoretical basis for the diagnosis and treatment of CRCC.]]> 2021/7/5 12:12:34 LI Bing-ying, LIU Chang, LI Feng, et al. 22true ［Abstract］　Objective　To explore the value of hematological infection and blood coagulation indicators including C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), fibrinogen(FBG), D-dimer and platelet(PLT) in diagnosis of chronic prosthetic joint infection(PJI). Methods　The data of 149 patients who were admitted to the Zhengzhou Central Hospital Affiliated to Zhengzhou University and completed the first joint replacement surgery from October 2018 to January 2021 were collected. The patients were divided into the chronic PJI group(47 cases) and the non-infected control group(102 cases) according to the situations of postoperative chronic PJI. The reexamination results of postoperative CRP, ESR, FBG, D-dimer, PLT and PLT/mean platelet volume(MPV) were compared between the two groups. Receiver operating characteristic curve(ROC) method was used to analyze the diagnostic efficacy of CRP, ESR, FBG, D-dimer, PLT and PLT/MPV for chronic PJI. Results　After joint replacement, the levels of CRP, ESR, FBG, D-dimer, PLT and PLT/MPV in the chronic PJI group were significantly higher than those in the non-infected control group(P<0.05). The results of ROC analysis showed that CRP, ESR, D-dimer, FBG, PLT/MPV were all valuable in the diagnosis of chronic PJI(P<0.05). Further analysis showed that CRP, ESR, FBG and D-dimer were not statistically different in the diagnosis of chronic PJI(P>0.05), and the diagnostic efficiency of CRP, ESR, FBG and D-dimer was significantly higher than that of PLT and PLT/MPV(P<0.05). However, the cut-off values of CRP, ESR, FBG and PLT/MPV in the diagnosis of chronic PJI were all within the normal ranges, while only the cut-off value of D-dimer was above the normal range. Conclusion　The efficacy of FBG, D-dimer, CRP and ESR in the diagnosis of chronic PJI is similar, and D-dimer index has more clinical guiding significance.]]> 2021/7/5 12:12:34 ZHANG Yong-chao, HUANG Jin-cheng, ZHANG Xin-an, et al. 21true ［Abstract］　Objective　To explore the association between folic acid levels and end-point events of cardio-cerebrovascular disease(CVD) and its gender differences. Methods　From January 2016 to December 2019, a total of 1 791 residents aged ≥15 years in Emin County, Xinjiang Uygur Autonomous Region were selected by multi-stage random sampling method for follow-up and investigation. The data were collected through on-site survey, telephone follow-up, household survey, and retrieval of medical records of residents from local county hospitals. Cox regression analysis and Directed Acyclic Graph(DAG) analysis were used to explore the correlation between folic acid levels and CVD end-point events. Results　A total of 1 687 respondents completed the follow-up, and 143 of them developed CVD end-point events, of which stroke and myocardial infarction accounted for 72.7%. For the total population, the risk of CVD end-point events in the folic acid <4.55 ng/ml group was higher than that in the folic acid 4.55-6.96 ng/ml group(HR=1.56, P=0.038). For the males, the risk of CVD end-point events in the folic acid <4.55 ng/ml group was higher than that in the folic acid >6.96 ng/ml group(HR=2.57, P=0.007). For the females, the risk of CVD end-point events in the folic acid <4.55 ng/ml group and the folic acid >6.96 ng/ml group was higher than that in the folic acid 4.55-6.96 ng/ml group(HR=2.11, P=0.026; HR=1.84, P=0.039). Conclusion　Low level of folic acid is associated with an increased risk of CVD end-point events, and for females, higher level of folic acid also promotes the occurrence of CVD end-point events.]]> 2021/7/5 12:12:34 YANG Zhi-kang, HEIZHATI·Mu-la-li-bie-ke, WANG Lin, et al. 20true ［Abstract］　Objective　To analyze the variation of pulmonary function indexes with time and the effect of target heart rate arrival and maintenance time on the decline rates of pulmonary function indexes during children′s exercise challenge test(ECT). Methods　A retrospective analysis was conducted on 60 cases of asthma and suspected asthma children treated in Children′s Hospital Affiliated to Chongqing Medical University from November 2016 to September 2020. All the children successfully completed bicycle ergometer ECT. A decrease of ≥10% in forced expiratory volume in one second(FEV₁) was considered as positive test. The basic data and pulmonary function data before and after the test were collected. The children were divided into two groups according to their target heart rate arrival time ≤4 min and >4 min. The children were divided into two groups according to their target heart rate maintenance time ≥4 min and <4 min. The variation of pulmonary function indexes with time and the differences in the decline rates of pulmonary function indexes were compared between the two groups. Results　Among the 60 children, 11 cases(18.33%) were positive and 49 cases(81.67%) were negative. The target heart rate maintenance time in the positive group was significantly longer than that in the negative group, and the difference was statistically significant(P<0.05). The large and small airway parameters decreased in different degrees after exercise, and gradually recovered after 20 min. The decline rates of the large airway parameters［forced vital capacity(FVC), FEV₁, peak expiratory flow(PEF), and forced expiratory flow at 25% vital capacity(FEF₂₅)］ in the target heart rate maintenance time ≥4 min group were higher than those in the target heart rate maintenance time <4 min group(P<0.05). Conclusion　During children′s ECT, the large airway and the small airway have different degrees of contraction after exercise, and gradually recover after 20 minutes. The target heart rate maintenance time can affect the contraction of the large airway. When reviewing the reports, pediatricians should pay attention to whether the guidelines have been met, in order to evaluate the reliability and applicability of the results, so as to make a more reasonable clinical diagnosis and treatment plan.]]> 2021/6/3 21:44:38 HUANG Jun, LUO Jian 19true ［Abstract］　Objective　To investigate the application value of lncRNA XIST in prediction of drug resistance and poor clinical prognosis in ovarian cancer, and to provide theoretical basis for its clinical application as a tumor marker. Methods　The difference of lncRNA XIST expression between ovarian cancer tissues and normal ovarian tissues was analyzed based on microarrays deposited in Oncomine database. Base on the independent expression profile chip of GEO and TCGA databases,Kaplan-Meier plotter and ROC plotter were used to analyze the association between lncRNA XIST and the patients′ prognoses and its value in prediction of chemotherapy resistance. Real-time quantitative polymerase chain reaction(RT-qPCR) was used to detect the expressions of lncRNA XIST in carboplatin-resistant ovarian cancer cells HeyA8-CBP and SKOV3-CBP, taxol-resistant cells HeyA8-R and SKOV3-R, and their sensitive cells HeyA8 and SKOV3. Results　Compared with that in normal ovarian tissues, the expression of lncRNA XIST in ovarian cancer tissues was significantly down-regulated(P<0.05). Compared with the high expression group of lncRNA XIST, the low expression group of lncRNA XIST had worse prognoses in overall survival(OS), progression-free survival(PFS), and post-progression survival(PPS)(P<0.05). The detection results of RT-qPCR showed that lncRNA XIST was significantly down-regulated in carboplatin-resistant ovarian cancer cells HeyA8-CBP and SKOV3-CBP, taxol-resistant cells HeyA8-R and SKOV3-R compared with that in sensitive cells HeyA8 and SKOV3(P<0.05). Meanwhile, the expression of lncRNA XIST was significantly decreased in drug resistant tissues compared with that in sensitive tissues, and low expression of lncRNA in drug resistant tissues might be a potential prediction of drug resistance in ovarian cancer(P<0.05). Further ROC plotter analysis results showed that for the resistance to all drugs, the warning cutoff value of lncRNA XIST was 8 977; for the resistance to platinum drugs, the predicted cutoff value was 8 977; for the resistance to paclitaxel, the predicted cutoff value was 8 245; for the resistance to platinum drugs+paclitaxel, the predicted cutoff value was 8 245, all of which had a certain predicted value(P<0.05). Conclusion　lncRNA XIST is expected to be used as a predictive marker for chemotherapeutic drug resistance to ovarian cancer and the patients′ prognoses, and has clinical application value.]]> 2021/6/3 21:44:38 CHEN Cui-lan, YIN Fu-qiang 18true ［Abstract］　Objective　To explore the effects of hyperuricemia on erectile function and serum testosterone level in mice. Methods　Thirty-four healthy adult male mice were randomly divided into experimental group(n=17) and control group(n=17). The experimental group was given oteracil potassium by gavage to construct a mouse model of hyperuricemia, and the control group was given normal saline by gavage. The serum uric acid level, testosterone level, erectile function of the penis and the content of nitric oxide(NO) in penile tissues were compared between the two groups. The morphology of interstitial cells in the testis tissues was observed in the mice of the two groups. Results　The number of erection in the experimental group was less than that in the control group, and the erection rate in the experimental group was lower than that in the control group, with statistically significant differences between the two groups(P<0.05). After 30 days of drug intervention, the level of serum uric acid in the experimental group was higher than that in the control group, and the levels of serum testosterone and NO in penile tissues in the experimental group were lower than those in the control group, with statistically significant differences between the two groups(P<0.05). Under the light microscope, the interstitial cells in the testis tissues of the experimental group were reduced in volume, and nucleus pyknosis, condensed chromatin, deep staining, and decreased intracellular lipid content were observed in the experimental group. The results of Pearson correlation analysis showed that the final serum uric acid levels of the mice in the two groups were significantly negatively correlated with testosterone level and erectile function(the number of erection)(P<0.05). Conclusion　The mechanism of penile erectile dysfunction in hyperuricemia mice may be related to the inhibition of NO content in penile corpus cavernosum by high uric acid and the decrease of serum testosterone level. The decrease of serum testosterone level in hyperuricemia mice may be related to the damage of Leydig cell structure and function.]]> 2021/6/3 21:44:38 YANG Shi-yun, YANG Jin-yue, LU Quan, et al. 17true ［Abstract］　Objective　To explore the influence of stress hyperglycemia on prognosis of cerebral hemorrhage after craniotomy for hematoma removal. Methods　The clinical data of 131 cerebral hemorrhage patients without a history of diabetes who were admitted to the Department of Neurosurgery, People′s Hospital of Baise from January 2018 to December 2019 were collected. All the patients were performed craniotomy for hematoma removal. According to whether stress hyperglycemia occurred after cerebral hemorrhage, the patients were divided into stress hyperglycemia group(blood glucose ≥6.9 mmol/L, normal glycosylated hemoglobin, 62 cases) and non-stress hyperglycemia group(blood glucose <6.9 mmol/L, normal glycosylated hemoglobin, 69 cases). The differences in the clinical data were compared between the two groups. Results　The level of fasting blood glucose in the stress hyperglycemia group at admission was significantly higher than that in the non-stress hyperglycemia group(P<0.05). There were no significant differences between the two groups in terms of age, gender, Body Mass Index(BMI), glycosylated hemoglobin at admission, hematoma volume, prothrombin time, fibrinogen, platelet count and the time between the onset and the operation(P>0.05). The proportion of the patients with postoperative rebleeding, intracranial infection and death 30 days after operation in the stress hyperglycemia group was significantly higher than that in the non-stress hyperglycemia group(P<0.05), and the ratio of postoperative stay in Intensive Care Unit(ICU) to total hospitalization time in the stress hyperglycemia group was significantly higher than that in the non-stress hyperglycemia group(P<0.05). The Glasgow Outcome Scale(GOS) scores 3 months after operation in the stress hyperglycemia group were significantly lower than those in the non-stress hyperglycemia group(P<0.05). Conclusion　Stress hyperglycemia can promote the occurrence of adverse events after craniotomy for hematoma removal, which should be paid attention to clinically.]]> 2021/6/3 21:44:38 ZHANG Kun-yuan, LIAO Chang-pin, LI Ting-yang 16true ［Abstract］　Objective　To analyze and compare the hematological indexes and the severity of coronavirus disease 2019(COVID-19) in patients with different ages and underlying diseases. Methods　One hundred and fifty COVID-19 patients admitted to Guangxi Nanning Fourth People′s Hospital and Huangpi District Chinese Medicine Hospital of Wuhan from January 22, 2020 to February 29, 2020 were selected as the research subjects. According to their ages, the patients were divided into young group(18-39 years old, 51 cases), middle-aged group(40-59 years old, 50 cases) and elderly group(≥60 years old, 49 cases); and the patients were divided into non-concomitant underlying disease group(126 cases) and concomitant underlying disease group(24 cases) according to their concomitant underlying diseases. The general clinical data and hematological indexes were compared among the groups. Results　The elderly group had the largest proportion of the patients with concomitant underlying diseases, followed by the middle-aged group and the young group, and the difference was statistically significant(P<0.05). The proportion of severe cases in the elderly group and the middle-aged group was significantly higher than that in the young group(P<0.05). There were significant differences in the lymphocyte count, red blood cell count and hemoglobin level among the three groups(P<0.05), and the levels of the elderly group were the lowest(P<0.05). There were significant differences in the levels of D-dimer, lactate dehydrogenase(LDH), total bilirubin(TBil) and blood urea nitrogen(BUN) among the three groups, and the levels of the elderly group were the highest(P<0.05). Compared with those in the non-concomitant underlying disease group, the patients in the concomitant underlying disease group were older, and had higher D-dimer and LDH levels, and the differences were statistically significant(P<0.05). Conclusion　Middle-aged and elderly patients with COVID-19 have more concomitant underlying diseases and a higher rate of severe cases. Old age and concomitant underlying diseases may be the risk factors for exacerbation of COVID-19 patients.]]> 2021/5/8 18:36:31 YU Qiao, JI Pan, ZHU Jie-yun, et al. 15true ［Abstract］　Objective　To explore the value of CURB-age score combined with inflammatory factor detection in predicting the short-term prognosis of elderly patients with community-acquired pneumonia(CAP). Methods　The clinical data of 112 elderly patients with CAP admitted to the General Ward and the Intensive Care Unit(ICU) of the Department of Respiratory Medicine, the Second Affiliated Hospital of Zhengzhou University, were collected from January 2016 to February 2020, and the patients were divided into survival group(95 cases) and death group(17 cases) according to their 30-day clinical outcomes. The clinical data were compared between the two groups, and multivariate logistic regression analysis was used to explore the risk factors affecting the death of the elderly CAP patients. The receiver operating characteristic(ROC) curve was drawn to analyze the predictive value of different combined models for 30-day mortality in the elderly CAP patients. Results　The CURB-age scores, CURB-65 scores, and the levels of C-reactive protein(CRP), CRP/prealbumin(PA), procalcitonin(PCT) and white blood cell(WBC) in the survival group were lower than those in the death group, while the level of PA in the survival group was higher than that in the death group, and the differences were statistically significant(P<0.05). The results of logistic regression analysis showed that a higher CURB-age score was a risk factor of death for the elderly CAP patients(OR=5.529, P=0.015). The areas under ROC curve(AUC) of CURB-age score, CURB-age score+CRP model, CURB-age score+PA model, CURB-age score+CRP/PA model, CURB-age score+PCT model and CURB-age score+WBC model were 0.894, 0.929, 0.947, 0.949, 0.916 and 0.906, respectively, suggesting that all of them had good predictive power(P<0.05). Further analysis showed that the AUCs of CURB-age score+PA model and CURB-age score+CRP/PA model were significantly greater than the AUC of CURB-age score(Z=2.326, P=0.020; Z=2.496, P=0.013), however there was no statistically significant difference in AUC among the other models(P>0.05). Conclusion　CURB-age score has good clinical predictive value for the short-term prognosis of elderly CAP patients, and is better than CURB-65 score. CURB-age score combined with PA can significantly improve its predictive efficacy.]]> 2021/5/8 18:36:31 WANG Qing-xiu, LIU Jian-bo, SHAO Run-xia, et al. 14true ［Abstract］　Objective　To analyze the relationship of cytokeratin 7(CK7), cytokeratin 19(CK19) and p16^INK4a(p16) expressions in tonsil squamous cell carcinoma(TSCC) tissue and crypt epithelium and surface epithelium of the pericarcinoma, and to explore their roles in the mechanism of human papilloma virus(HPV) infection-mediated tonsillar carcinogenesis. Methods　The case data and tissue samples of 17 TSCC patients admitted to the Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangxi Medical University from July 2015 to January 2018 were selected. Serial paraffin sections were performed on the TSCC tissue samples, and immunohistochemistry was used to detect the expressions of CK7, CK19, and p16. The expression intensity, location and relationship of the three markers were observed and analyzed. Results　The positive staining of CK7, CK19, and p16 was located in the cytoplasm. In the TSCC tissues, their staining was patchy or diffuse, while in the normal epithelium around the TSCC cancer, their staining was patchy. CK7 was mainly expressed in the epithelial surface, while CK19 was mainly expressed in the subepithelial and basal cells. p16 was mainly expressed in the lower third of the epithelium to the whole layer, and basically overlapped with CK19. For HPV-mediated(p16⁺) TSCC, the results of Kappa consistency analysis showed that the detection results of CK7 and CK19, CK7 and p16, and CK19 and p16 were consistent(P<0.05); however, for non-HPV-mediated TSCC, the detection results of the three markers did not show a significant correlation(P>0.05). For the pericancerous crypt epithelium tissues and pericancerous surface epithelium tissues around the TSCC cancer, the results of Kappa consistency analysis showed that the detection results of CK7 and CK19, CK7 and p16, and CK19 and p16 were all consistent(P<0.05). Conclusion　The expressions of CK7, CK19 and p16 are closely related to the occurrence of HPV-mediated(p16⁺) TSCC, and there may be a mechanism of “CK7→CK19→p16 axis”.]]> 2021/5/8 18:36:31 YAN Qi-zhang, CHEN Hai-bo, LU Ying, et al. 13true ［Abstract］　Objective　To analyze the influencing factors of type 2 diabetes mellitus patients complicated with hypertension in Nanning communities. Methods　A total of 496 patients with type 2 diabetes mellitus were selected from Nanning urban area(Qingxiu District) and rural area(Hengxian County) by multi-stage random sampling method from May 2017 to July 2017. Among them, 299 cases were in the urban area and 197 cases were in the rural area. The patients′ information was collected by questionnaire and physical examination, and the factors affecting the occurrence of hypertension in the type 2 diabetes mellitus patients were investigated by binary logistic regression analysis. Results　A total of 293 patients(59.07%) with diabetes mellitus complicated with hypertension were detected in this study. The results of binary logistic regression analysis showed that higher education level(OR=0.501, 95%CI:0.286-0.876) and participation in physical exercise(OR=0.652, 95%CI:0.426-0.999) were the protective factors for inhibiting the occurrence of hypertension in the type 2 diabetes mellitus patients, while drinking habit(OR=2.156, 95%CI:1.219-3.811) and larger waist circumference(OR= 1.038, 95%CI:1.016-1.060) were the risk factors for promoting the development of hypertension in the type 2 diabetes mellitus patients. Conclusion　The prevalence of hypertension in type 2 diabetes mellitus patients is relatively high. In diabetes management, more attention should be paid to the drinking behavior and waist circumference control in order to better control the blood pressure of diabetic patients and improve their quality of life.]]> 2021/5/8 18:36:31 LIANG Qiu-li, WANG Jian, ZHOU Ji, et al. 12true ［Abstract］　Objective　To detect the expression of clusterin(CLU) in liver cancer cell HepG2 and to construct the promoter expression plasmid of liver cancer differential expression gene CLU, so as to lay a foundation for further study on the differential expression and mechanism of CLU gene. Methods　The expression levels of CLU mRNA in hepatocellular carcinoma(HCC) cell HepG2 and normal hepatocyte L02 were detected by real-time fluorescent quantitative polymerase chain reaction(RT-qPCR). The promoter sequence of CLU gene was obtained by bioinformatics analysis and promoter sequencing, and was constructed into pGL3-Basic plasmid. The constructed pGL3-CLUP plasmid was verified by restriction enzyme digestion, agarose gel electrophoresis and sequencing. Results　The RT-qPCR results showed that the expression level of CLU mRNA in HepG2 cells was 9.38 times higher than that in L02 cells, and the difference was statistically significant(P<0.05). The pGL3-CLUP plasmid was a single band after single enzyme digestion, and the length was about 5 000-6 000 bp. After double enzyme digestion, two bands appeared, one of which was about 5 000 bp and the other was about 1 000-1 500 bp. The length was consistent with the size of plasmid and promoter. The sequencing results also showed that the CLU promoter had been inserted into the promoter region of pGL3-Basic plasmid. Conclusion　CLU is highly expressed in HCC cells. pGL3-CLUP promoter expression plasmid is constructed successfully.]]> 2021/4/2 14:58:35 YU Qiu-li, WANG Feng 11true ［Abstract］　Objective　To explore the expression, clinical significance and mechanism of chromobox 8(CBX8) in hepatocellular carcinoma(HCC), and to provide new ideas and directions for the prevention, diagnosis, treatment and prognosis of HCC. Methods　Based on bioinformatics methods, the expression and gene mutation of CBX8 in HCC tissues were analyzed using tumor gene databases, and their relationship with demographic characteristics, pathological characteristics and prognosis of HCC was analyzed. The protein expression level of CBX8 gene was analyzed by protein-related databases, and the related protein interaction network was constructed and the pathway enrichment analysis was carried out. Results　The expression level of CBX8 mRNA in the HCC tissues was higher than that in the normal liver tissues. The expression of CBX8 mRNA in the HCC tissues was related to weight, TP53 mutation, histological classification, and tumor stage(P<0.05). The HCC patients with high expression level of CBX8 mRNA had a lower overall survival rate(P<0.05). The mutation types of CBX8 gene were mainly C>T mutation and missense mutation. CBX8 was mainly involved in cell cycle, histone generalization and other physiological processes, and might play a role in signaling pathway to regulate pluripotency of stem cells and cancer-associated microRNA network. Conclusion　CBX8 is highly expressed in HCC and is related to the prognosis of HCC, and may be involved in the occurrence and development of HCC.]]> 2021/4/2 14:58:35 REN Guan-hua, ZHANG Chao-jun, MEI Fan-biao, et al. 10true ［Abstract］　Objective　To explore the predictive value of preoperative systemic immune-inflammation index(SII) in the recurrence and metastasis of triple-negative breast cancer(TNBC). Methods　The clinical data of 100 female patients with primary TNBC admitted to the Department of Thyroid and Breast Surgery, the 904th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army from January 2011 to September 2019 were collected. The patients′ SII values were calculated, and their best cut-off values were determined by receiver operating characteristic curve(ROC). The patients were divided into high SII group(42 cases) and low SII group(58 cases) according to their different best cut-off values. Kaplan-Meier method was used to draw the patients′ survival curve, and log-rank test was used for univariate analysis of postoperative recurrence and metastasis of triple-negative breast cancer, and Cox regression model was used for multivariate analysis to explore the risk factors affecting the prognosis of TNBC. Results　The 1, 3, and 5-year disease-free survival(DFS) rates of TNBC patients after surgery in the high SII group and the low SII group were 81.0%, 46.3%, 41.0% and 98.3%, 84.1%, 76.0%, respectively, and the average DFS time was 50.0 and 83.1 months, respectively. The prognosis of DFS in the low SII group was significantly better than that in the high SII group(P<0.05). Univariate analysis showed that T staging, N staging, pTNM staging, Ki-67 and preoperative SII were associated with postoperative recurrence and metastasis of TNBC patients(P<0.05). The results of Cox regression analysis showed that higher T staging(HR=7.806, 95%CI=3.290-18.523, P=0.000), N staging(HR=3.526, 95%CI=1.763-7.050, P=0.000) and preoperative SII(HR=3.440, 95%CI=1.763-6.710, P=0.000) were the risk factors affecting the prognosis of DFS in TNBC patients. Conclusion　SII is related to the prognosis of DFS in TNBC patients, and the higher level of preoperative SII is an independent risk factor affecting recurrence and metastasis of TNBC patients after surgery. SII can evaluate the prognosis of the patients conveniently and effectively, and has clinical application value.]]> 2021/4/2 14:58:35 ZHU Meng-jiao, LUO Kun-lun, RUI Xiao-ping, et al. 9true ［Abstract］　Objective　To analyze the expression of PDZ-binding kinase/T-LAK cell-originated protein kinase(PBK/TOPK) in breast cancer(BRCA) by bioinformatics and its clinical significance, and to predict its potential molecular pathways and biological functions. Methods　Oncomine database was mined to analyze the expressions of PBK/TOPK messenger ribonucleic acid(mRNA) in different cancers. Ribonucleic acid(RNA) sequencing data and clinical information of BRCA tissue and normal breast tissue were downloaded from the Cancer Genome Atlas(TCGA) database to analyze the correlation between PBK/TOPK mRNA expression and clinical characteristics, and survival analysis was performed using the Kaplan-Meier Plotter database. The related genes of PBK/TOPK were screened, and functional enrichment analysis was performed to predict the potential molecular pathways and biological functions of PBK/TOPK in BRCA. Results　The expression of PBK/TOPK gene in BRCA tissue was significantly higher than that in normal breast tissue(P<0.05), and was correlated with estrogen receptor(ER), progesterone receptor(PR), triple negative breast cancer(TNBC) and menopause status(P<0.05). Survival analysis showed that the high expression of PBK/TOPK gene indicated a poor prognosis of BRCA(P<0.05). Functional enrichment analysis showed that similar genes of PBK/TOPK were mainly involved in biological functions such as cell division, cell cycle regulation and microtubule cytoskeleton formation in BRCA, and involved in BRCA cell cycle and other signaling pathways. Conclusion　PBK/TOPK mRNA is highly expressed in BRCA tissues, which is related to poor prognoses of BRCA patients. PBK/TOPK mRNA can be used as a potential biomarker and therapeutic target for BRCA.]]> 2021/3/5 17:41:47 LI Feng, LI Bing-ying, XIE Huan, et al. 8true ［Abstract］　Objective　To analyze the correlation of serum lipoprotein-associated phospholipase A₂(Lp-PLA₂) and gamma-glutamyl transferase(GGT) with coronary heart disease(CHD) and severity of coronary artery disease. Methods　The clinical data of 170 patients with suspected CHD who first visited the Department of Cardiology, the Second Affiliated Hospital of Zhengzhou University from June 2018 to June 2019 were selected, and the patients were divided into CHD group(103 cases) and non-CHD group(67 cases) according to the results of coronary angiography. The patients′ serum levels of Lp-PLA₂ and GGT were detected, and the relationship between serum Lp-PLA₂, GGT and CHD and the severity of coronary artery disease was analyzed. Results　The levels of Lp-PLA₂, GGT, triglyceride(TG), low density lipoprotein(LDL) and Gensin score, and the proportion of the patients complicated with hypertension and diabetes in the CHD group were significantly higher than those in the non-CHD group(P<0.05), while the level of high density lipoprotein(HDL) was significantly lower than that in the non-CHD group(P<0.05). The results of Spearman correlation analysis showed that the serum levels of Lp-PLA₂ and GGT in the CHD patients were positively correlated with the number of coronary artery lesions(r_s=0.681, P=0.000; r_s=0.603, P=0.000). The results of Pearson correlation analysis showed that the serum levels of Lp-PLA₂ and GGT in the CHD patients were positively correlated with the Gensin score(r=0.799, P=0.000; r=0.621, P=0.000). The results of multivariate logistic analysis showed that higher levels of Lp-PLA₂, GGT, LDL, and associated hypertension were the risk factors promoting the occurrence of CHD(P<0.05); and higher levels of HDL were the protective factors inhibiting the occurrence of CHD(P<0.05). Conclusion　Higher levels of serum Lp-PLA₂ and GGT are the risk factors promoting the occurrence of CHD, which can better reflect the severity of coronary artery disease and can be used as a reliable indicator to evaluate the occurrence and progression of CHD.]]> 2021/3/5 17:41:47 JIA Meng-qi, GUI Shuang-jun, LIU Shi-chao, et al. 7true ［Abstract］　Objective　To analyze the differences in behavior problems and social living ability of children with different subtypes of attention deficit hyperactivity disorder(ADHD), so as to provide basis for clinical treatment. Methods　According to the Diagnostic and Statistical Manual of Mental Disorders(DSM-Ⅴ) diagnostic criteria, 225 children with ADHD were enrolled, including 103 cases of combined type of ADHD(ADHD-C), 90 cases of predominantly inattentive type of ADHD(ADHD-I), and 32 cases of predominantly hyperactive/impulsive type of ADHD(ADHD-HI), and 112 normal children were included in the same period. Conners Parent Symptom Questionnaire(PSQ) and Normal Development of Social Skills from Infant to Junior High School Children(S-M) were respectively used to evaluate and compare the differences in behavior problems and social living ability between ADHD children and normal children, and among different subtypes of ADHD children. Results　The scores of six factors of behavioral problems in ADHD children(conduct problems, learning problems, psychosomatic problems, Impulse-hyperactivity Index, anxiety and Hyperactivity Index) were higher than those in the children in the normal control group(P<0.01), while the various social living abilities of ADHD children were lower than those of the children in the normal control group(P<0.05). Spearman correlation analysis showed that the higher the scores of conduct problems, learning problems, Impulse-hyperactivity Index, and Hyperactivity Index in ADHD children, the lower the total score of social living ability(P<0.01). The scores of conduct problems, learning problems, Impulse-hyperactivity Index, and Hyperactivity Index of ADHD-C children were higher than those of the other two subtypes children, and the scores of learning problems of ADHD-I children were higher than those of ADHD-HI children(P<0.05), and the Impule-hyperactivity Index scores of ADHD-I children was lower than those of ADHD-HI children. Compared with ADHD-I children and ADHD-HI children, ADHD-C children had the worse total score of social living ability, independent living ability, homework, communication, group activity and self-management ability(P<0.05). Conclusion　Children with ADHD have more obvious behavior problems than normal children, and the social functional impairment of the ADHD children is more serious, and the more serious the behavior problems, the worse their social living ability. The clinical characteristics of children with different subtypes of ADHD are different, and the behavior problems and functional impairment caused by the different subtypes of ADHD are also inconsistent.]]> 2021/2/3 9:17:59 LIAN Qiong-xia, WANG Zhen-zhen, ZHANG Juan, et al. 6true ［Abstract］　Objective　To investigate the predictive value of serum aldosterone level for postoperative recurrence of persistent atrial fibrillation(AF) after first catheter ablation. Methods　A total of 51 AF patients undergoing first catheter ablation were continuously chosen from Fuyang People′s Hospital during October 2018 and September 2019. The recurrence of AF was defined as AF, atrial flutter, and atrial tachycardia with duration ≥30 s after catheter ablation for 3 months. The patients were followed up for 1 year after the operation. According to the follow-up results, the patients were divided into recurrence group and non-recurrence group, and the predictive value of related factors in recurrence of AF was analyzed. Results　One year after the operation, 19 cases(37.3%) relapsed. The results of multivariate logistic regression analysis showed that preoperative serum aldosterone level in the patients with persistent AF was an independent predictive factor of AF recurrence after catheter ablation(OR=1.037, 95%CI: 1.011～1.064, P=0.005). The results of receiver operating characteristic(ROC) curve showed that the area under curve(AUC) of aldosterone level for predicting AF recurrence after catheter ablation was 0.752(95%CI: 0.611～0.862, P<0.001), and the optimal cut-off value of preoperative serum aldosterone level to predict postoperative recurrence was 136.43 ng/dl. Conclusion　The level of serum aldosterone in patients with persistent AF undergoing catheter ablation is closely related to postoperative recurrence, which can be used as an indicator to predict the recurrence of AF.]]> 2021/2/3 9:17:59 YANG Wen-wu, NING Bin 5true ［Abstract］　Objective　To explore the risk factors affecting lymph node metastasis(LNM) in patients with high-risk prostate cancer. Methods　The clinical data of 105 high-risk prostate cancer patients who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2016 to December 2020 were selected, all of whom received extra-peritoneal laparoscopic radical prostatectomy(eLRP)+extended pelvic lymph node dissection(ePLND) treatment. The patients were divided into case group(LNM positive, 14 cases) and control group(LNM negative, 91 cases) according to their lymph node pathology results. The preoperative age, Body Mass Index(BMI), prostate specific antigen(PSA), Gleason score(GS), percentage of positive biopsy cores(PPBC), prostate volume(PV), and prostate clinical stage were compared between the two groups. Binary logistic regression and nomogram were used to analyze the factors affecting LNM of the patients. Results　The proportion of the patients in the case group with GS>8 points and the clinical stage of prostate cancer >T2c stage was greater than that in the control group, and PPBC in the case group was higher than that in the control group, and the differences were statistically significant(P<0.05). The results of binary logistic regression analysis showed that the clinical stage of prostate cancer >T2c stage(OR=7.128, 95%CI: 1.316-38.618), PSA 10-20 ng/ml(OR=10.679, 95%CI: 1.014-112.512), GS>8 points(OR=16.387, 95%CI: 2.147-125.092) and greater PV(OR=2.938, 95%CI: 1.266-6.822) were the risk factors for promoting LNM(P<0.05). The nomogram analysis showed that the clinical stage of prostate cancer and GS had higher predictive value. Conclusion　PSA, GS, clinical stage of prostate cancer and PV are all related to the occurrence of LNM for high-risk prostate cancer, and the clinical stage of prostate cancer and GS have the highest predictive value.]]> 2021/11/2 15:11:32 SONG Hong-wen, YAN Shen-shen, ASIMUJIANG Abula, et al. 4true ［Abstract］　Objective　To explore the clinical significances of tumor markers endothelial cell specific molecule-1(ESM-1), matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9) in differentiating benign and malignant pleural effusions. Methods　Ninety-nine pleural effusion patients admitted to the Department of Cardiothoracic Surgery, Guangzhou Red Cross Hospital Affiliated to Jinan University from January 2018 to March 2019 were selected, including 53 patients with malignant pleural effusion(malignant pleural effusion group) and 46 patients with benign pleural effusion(benign pleural effusion group). Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of ESM-1, MMP-2 and MMP-9 in the patients′ pleural effusion. The receiver operator characteristic(ROC) curve was used to analyze the diagnostic efficacy of ESM-1, MMP-2 and MMP-9 in differentiating benign and malignant pleural effusions. Results　The levels of ESM-1, MMP-2 and MMP-9 in pleural effusion in the malignant pleural effusion group were significantly higher than those in the benign pleural effusion group(P<0.05). The pathological type and T stage of patients with malignant pleural effusion were significantly correlated with the levels of ESM-1, MMP-2, and MMP-9 in pleural effusion(P<0.05). The metastasis of distant organs had a significant relationship with the levels of MMP-2 and MMP-9(P<0.05), but did not have a significant relationship with the level of ESM-1(P>0.05). The results of ROC curve analysis showed that ESM-1, MMP-2 and MMP-9 had diagnostic value in differentiating benign and malignant pleural effusions(P<0.05), and their cut-off values were 40.110 ng/ml, 446.690 ng/ml and 145.560 ng/ml, respectively. The results of the combined diagnosis of ESM-1, MMP-2 and MMP-9 showed that the combination of MMP-2+MMP-9 had the highest sensitivity(96.2%), and the combination of MMP-2+ESM-1 had the highest specificity( 89.1%), and the combination of ESM-1+MMP-2+MMP-9 had the best diagnostic performance［area under the curve(AUC)=0.928］. Conclusion　The expression levels of ESM-1, MMP-2 and MMP-9 in malignant pleural effusion are significantly increased, which can be used as indicators to differentiate benign from malignant pleural effusions. The combined diagnosis of the three tumor markers is more effective.]]> 2021/11/2 15:11:32 LIU Qing-feng, WU Wei-dong, GU Jia-sheng, et al. 3true ［Abstract］　Objective　To investigate the correlation and consistency of the detection results between thromboelastography(TEG) and routine coagulation test in patients with lower extremity deep venous thrombosis(DVT). Methods　The detection results of TEG and routine coagulation test in eighty-seven DVT inpatients admitted to the Department of Intervention, Hefei Hospital Affiliated to Anhui Medical University from September 2017 to January 2021 were retrospectively analyzed, and the detection results of the two different methods were statistically analyzed. Results　There was a significant correlation between the relevant parameters of TEG and the detection indicators of routine coagulation test. The R value of TEG was positively correlated with prothrombin time(PT) and activated partial thromboplastin time(APTT)(r=0.231, r=0.395). The K value of TEG was positively correlated with APTT(r=0.237), and negatively correlated with fibrinogen(FIB) and platelet count(PLT)(r=-0.521, r=-0.431). The α-angle of TEG was positively correlated with the values of FIB and PLT(r=0.542, r=0.471), and the value of MA of TEG was positively correlated with the values of FIB and PLT(r=0.674, r=0.596), and the differences were significant(P<0.05). For the judgment of coagulation state, the MA value of TEG is consistent with PLT and FIB(Kappa=0.148, Kappa=0.210; P<0.05). Conclusion　For DVT patients, there is a significant correlation between TEG detection and routine coagulation test detection, but the consistency between the two methods is poor, and the two methods can not replace each other. TEG provides additional information besides that provided by routine coagulation test and is worthy of further clinical application.]]> 2021/11/2 15:11:32 ZHANG Hao-dang, YIN Shi-wu, PAN Sheng-quan 2true ［Abstract］　Objective　To explore the clinicopathological characteristics of gastrointestinal stromal tumors(GISTs) with smooth muscle differentiation. Methods　The medical records of 65 patients with GISTs admitted to the Second Affiliated Hospital of Guilin Medical College from April 2016 to November 2019 were retrospectively analyzed. The lesions were surgically excised in all the patients, and the immunohistochemical streptavidin-biotin complex(SABC) method was used to detect the expressions of smooth muscle-derived markers H-caldesmon, desmin and smooth muscle myosin heavy chain(SMMHC). The correlations between their expressions and the patients′ pathological characteristics were analyzed. Results　Among the 65 cases of GISTs, 43 cases(66.15%) were accompanied by smooth muscle differentiation. Of the 43 cases, 30 cases(46.15%) were positive for H-caldesmon, 7 cases(10.77%) positive for desmin, and 6 cases(9.23%) positive for SMMHC. H-caldesmon was significantly correlated with tumor diameter and risk grade(P<0.05). Desmin and SMMHC were not significantly correlated with gender, age, tumor diameter, mitotic number and risk grade(P>0.05). In combination of the three indicators, GISTs with smooth muscle differentiation were significantly correlated with tumor diameter, mitotic number and risk grade(P<0.05), but were not significantly correlated with age and gender(P>0.05). Conclusion　GISTs patients with smooth muscle differentiation may have a better prognosis.]]> 2021/11/2 15:11:32 WU Jin-feng, QIN Ya-ping, CHEN Ling-feng, et al. 1true