［Abstract］　Objective　 To investigate the efect of esomeprazole-and omeprazole based triple therapy regimens in the treatment of duodenal ulcer with Helicobacter pylori (HP)infection.Methods　 82 patients with duodenal ulcer and HP infection were randomly divided into two groups. EAC group (41 cases)treated with esomeprazole amoxicillin and clarithromycin twice daily and OAC group (41 cases) treated with omeprazole, amoxicillin and clarithromycin twice daily. The treatment lasted for 14 days, after which ulcer healing rate and eradication rate of HP as well as clinical remission rate were evaluated and compared.Results　On the first, the second and third days of medication, the clinical remission rates were 34.1%、58.5% and 70.7% respectively in group EAC, significantly higher than those in group OAC(14.6%、36.6%and 58.5%, respectively, P<0.05), ulcer healing rate and HP eradication rate were 95.1% and 92.7% in group EAC and 87.8%　and 85.3% in group OAC, showing no significant diferences between the two groups(P>0.05).The adverse effects of the medication were rare in both groups without significant differences. Conclusion　Esomeprazole based triple therapy may capable of achieving more speedy clinical remission than omeprazole based therapy.]]> 2018/12/13 9:30:20 YAN Kai-hua, ZHU Ming-yan, HU Lin, et al. 734true ［Abstract］　Objective　To observe the benefit of improvement in clinical symptoms of the method of activating collaterals to promote blood circulation and replenishing Qi to tonify the kidney (Activating method), in the treatment of patients with COPD, and to evaluate the affection of the method on the patients′ clinical symptom and lung function.Methods　Ninety patients who were in the acute phase of the COPD, were randomly divided into three groups. Treatment group were treated by combined western medicine treatment (routine method) and the activating method. Control group were treated by the routine method and the method of promoting blood circulation to remove blood stasis (promoting method). Routine group were treated by the routine method, such as anti-inflammatory, relieving dyspnea, facilitating expectoration. The clinical watching time was six months.Results　(1)The treatment group had bigher improvement ratio than the control and routine group, especially the symptom of cough, expectoration, gasp, wheezing rale had more remarkable improvement(P<0.05). The effect percentage of the cough anesis was 37%, expectoration was 42%, gasp was 18.7% in treatment group. The reduction of wheezing rale is more remarkable in physical sign.(2)As for total curative effect, treatment group had an advantage over the other groups (P<0.05).(3)There were significant differences in the improvement of Zrs, R% before and after treatment in the treatment group. Conclusion　The method of activating collaterals to promote blood circulation and replenishing Qi to tonify the kidney plays some effect on the improvement of clinical symptoms and lung function for the patients who were in the phase of the illness.]]> 2018/12/13 9:30:20 LIANG Jian-ping, XU Ping, LI Ping, et al. 733true ［Abstract］　Objective　To observe and compare the effects of three different surgical treatment for heavy craniocerebral injury.Methods　The 108 cases were randomly divided into three groups：Improved pterional approach group, the traditional bone group, the standard large trauma decompression group.The efficient rate and complication rate among the three groups were compared.Results　Improved pterional approach group was significantly superior to the traditional bone group and the standard large trauma decompression group in the cure rate, the rate of the disabled and the complication rate（P<0.05）.Conclusion　Improved pterional approach surgery has lots of characteristics, such as revealed extension, full decompression, with low rate of encephalocele, easily reset of cerebral hernia and so on. It is an effective way to treat heavy craniocerebral injury.]]> 2018/12/13 9:30:20 LUO Sheng, WANG Yu 732true ［Abstract］　Objective　To observe the association between blood pressure and vascular cognitive impairment (VCI) in people with senile essential hypertension (EH)and investigate the effect of senile EH on VCI.Methods　Patients of senile EH were separated into A group with VCI and B group with non-VCI and the parameters of ambulatory blood pressure (ABP) were collected for review analysis.Results　All arithmetic means including 24hMsBP, 24hMPP, 24hMdBP, 24hMAP in A group were smaller than those of B group. There were significant differences between two groups (P<0.05) via t test analysis.Conclusion　Personal therapy method and BP standard should be emphasized in patients with senile EH, especially in those with acute stroke.Excessive reduction of BP and inappropriate antihypertensive therapy may induce negative effect on cognitive function of aged people.]]> 2018/12/13 9:30:20 LU Ping-ping, ZHOU Shao-feng, FU Wei-ming 731true ［Abstract］　Objective　To investigate the therapeutic effect of hemodiafiltration (HDF) and intermittent hemodialysis(IHD)on senile patients with chronic renal failure, the incidence of dislysis correlative syndrome, and the effect on the nutritional status.Methods　Forty-five cases were divided in to two groups: 23 cases with hemodiafiltration therapy (group HDF), and 22 patients treated with intermittent hemodialysis (group IHD). The levels of urea nitrogen (Bun), serum creatinine (Scr), hemoglobin and serum albumin were detected; the loss of sebum cutaneum and skeletal muscle, the incidence of pleural fluid and hydroperitoneum were observed; the values of urea nitrogen clearance (kt/V) were calculated; and the incidence of complication in each group was compared in all cases before and after treatment.Results　kt/V>12 in HDF group while kt/V<12 in IHD group. The differences of dialysis adequacy between the two groups were significant (P<0.05). The levels of hemoglobin and serum albumin in HDF group were significantly higher than those in group IHD. There was no obvious loss of sebum cutaneum and skeletal muscle in group HDF. There was low incidence of pleural fluid and ascites in group HDF.Conclusion　Hemodiafiltration can obviously improve the quality of life of patients, and it is a better way for treating chronic renal failure.]]> 2018/12/13 9:30:20 WU Qiu-xia, GONG Zhi-feng, PENG Xiao-mei, et al. 730true ［Abstract］　Objective　To investigate the effects of flurbiprofen axetil administration on postoperative analgesia in gynecological patients undergoing abdominoscopy with fast track anesthesia.Methods　 Forty-five gynecological patients undergoing abdominoscopy with fast-tract anesthesia randomly divided into three groups equally with 15 cases each. Group A was injected with flurbiprofen axetil 50mg before anesthetic resuscitation and after six and twelve hours of the end of the operation. Group B was administrated PCIA before anesthetic resuscitation. The PCIA with fentanyl 1mg in 100ml normal saline was 2ml/h, lock time 20 min. Group C was injected normal saline 10ml after the operation, then six hours after operation. Analgesia grade were accessed and side effects were recorded.Results　The VAS value in group C was higher than in group A and group B in 2 hours, 6hours, 8hours and 12 hours after operation（P<0.05%）.There were no significant difference between group A and group B in every VAS′s recorded（P>0.05）.The side effect of nauseated, vomit, pruritus and drowsiness in group B were higher than in group A （P<0.05）. There was no significant difference of side effect in group A and in group C（P>0.05）.There were also no significant different of the score of total analgesia impression（P>0.05）. Conclusion　 Flurbiprofen axetil is good to the post operation analgesia in gynecological patients undergoing abdominoscopy with fast-tract anesthesia and reduce side effect.]]> 2018/12/13 9:30:20 ZENG Jing-xian, XIA Shu-xuan, MIAO Li-ping 729true ［Abstract］　Objective　To analyze the skin allergen test in a comparative way among cases with allergic rhinitis(AR) tested with Dermatophagoides pteronyssinus(Der p) allergen.Methods　Three hundred and six cases with moderate to severe AR underwnet intradermal test (IDT) or skin prick test (SPT) randomly. IDT was performed by using domestic Der p allergen fluid, and SPT was performed by using standardized Der p allergen fluid of allergopharma, histamine was positive control, normal saline was negative control, respectively. The degree of positive skin reactivity was scored as (+, ++, +++) and (++++). Then, their testing results were observed respectively and compared each other. Results　There were 154 cases received IDT, another 152 cases were given SPT. IDT was positive in 88.69% of patients, SPT was positive in 90.79% of patients, there were no significant differences between them (P>0.05), but the score of the skin test was≥++ rate of group SPT was significantly higher than that of group IDT(P<0.001).All the side effects were light. Conclusionn　The higher positive rate with Der p test can be determined by all the two kinds of inspiratory allergen series prepared in any ways, either as domestic Der p allergen fluid or standard Der p Allergopharma. The SPT tests are more sensitive and equally specific compared with the IDT method.]]> 2018/12/13 9:30:20 LU Qiu-tian, LIANG Jian-ping, HE Ning, et al. 728true ［Abstract］　Objective　 To investigate the better method for the patients of upper eyelid slack. Methods　The patients were divided into two groups : the traditional operation group was given the double eyes operation and the improvement operation group was given the operation from eyebrow and double eyes to remove the slack skin.Results　 The satisfaction ratio in the improvement operation group was higher than in the traditional operation group（P<0.01），then the standardization of operation method for the improvement operation were established. Conclusion　There is the better effect through the improvement operation, not only rectify the upper eyelid slack but also abate the wrinkle of forehead and outboard canthus, to renew the aspect of eyes and eyebrow, it worth while to use in the large scale. To establish the standardization program is the pledge for the better effect.]]> 2018/12/13 9:30:20 MAI Hui, YANG Ke-di, HE Ming 727true ［Abstract］　Objective　To estimate the role of statins in secondary prevention of ischemic cerebrovascular disease.Methods　Fifty-nine patiens of ischemic cerebrovascular disease were randomized to control and therapy group, followed for two years. Aspirin and statins were administered to the therapy group, aspirin without statins to the control.Results　The recurrence in the therapy group was significant lower than in the control group.Conclusion　Statins is important in secondary prevention of ischemic cerebrovascular disease.]]> 2018/12/13 9:30:20 HUANG Zhong-wei 726true ［Abstract］　Objective　To study the high-frequency ultrasound and color doppler characteristics of different pathological orbital tumors and find out some ultrasonographic diagnostic criteria.Methods　The ultrasonographic features and the predilection sites of 68 tumors were retrospectively analyzed and compared with the results of pathological findings after operation.Results　 Sixth-eight orbital tumors were classified into different groups according to the pathological morphology, such as vascular-originated tumors, nerve-originated tumors, lacrimal gland, phlegmasia mass, lymphoma, malignancy and others. Ultrasonic imaging characteristics differentiated from each other in the different groups. The internal ulrasonographic features of the orbital tumors were correlated with their pathological morphology. The predilection sites of tumors correlated with their pathological peculiarities. Color flow presentation rates, flow speed and their resistance indexes in each group were also studied and statistically analyzed.Conclusion　 Compared with the pathological morphology, high-frequency imaging has certain ultrasonographic feature. Combining age, predilection sites and clinical presentations will be great aids to the pathological nature diagnosis of the tumors.]]> 2018/12/13 9:30:20 WANG Xiao-yan, KANG Li-ke, LAN Chun-yong, et al. 725true ［Abstract］　Objective　To evaluate the therapeutic effects of sodium nitroprusside, dopamine and dobutamine on patients with refractory heart failure by continuing minipumpinjections.Methods　All patients were gived oxygen, appeasement, reducing activity and food, anti-infection.The treatment group were gived with sodium nitroprusside by a speed of 1-4mg/hour, dopamine, 8-32mg/hour and dobutamine 4-16mg/hour.The control group were given digitalis. The course of treatment was seven days.Results　 The total effective rate of the treatment group was 93.7% and the control group was 75.0%.The contrast difference was significance (P<0.01). Conclusion　The therapeutic effects of sodium nitroprusside, dopamine and dobutamine on patients with refractory heart failure are significant.]]> 2018/12/13 9:30:20 HE Xian-guang, LIU Zhao-hong 724true ［Abstract］　Objective　To observe the influence of two canal length measurement on the quality of root canal obturation. Methods　Three hundred and fifty two permanent teeth with single root canal which need root canal therapy were selected and divided randomly into two groups. A group: to measure the length of root canal by TRRY, prepare the root canal and test the trial point for a best position of the major Gutta Percha point in root canal, then take X-ray photos. After that obturate the root canal with lateral compaction and take X-ray photos. B group: to measure the length of root canal by root canal probes, prepare the root canal and test the trial point for a best position of the major Gutta Percha point in root canal, then take X-ray photos. After that obturate root canal with lateral compaction and take X-ray photos.Results　Within 1.0 mm the TRRY＇s accuracy in A group was 94.32% and 78.41% in B group. There was significant difference between them(P<0.01). The rate of best root canal obturation in A group was 90.37%, and in B group was 75.76%. There was significant difference between them(P<0.01).The effect of A group was better than B group obviously.Conclusion　The appliance of TRRY and trial point testing in root canal therapy then take X-ray photos may improve the quality of obturation remarkably.]]> 2018/12/13 9:30:20 CHEN Yan, LI Shi-jian, FA Ping, et al. 723true ［Abstract］　Objective　 To explore the recent curative effect of combining ACEI—enalapril with ARA-aldactone in the treatment of chronic heart failure. Methods　Ninety-five patients with chronic heart failure were randomly divided into two groups.The control group(n=43) were given oral digoxin 0.125～0.25mg once daily, hydrodiuril 25mg once or twice daily. The treatment group(n=52) were given oral enalapril 5～10mg once daily and aldactone 20mg twice daily on the basis of same therapy used in control group. The therapeutic course of the both groups was four weeks.The therapeutic efficacy before and after therapy are compared between two groups, so did the changes of function of left ventricl(SV, CO and LVEF). Results　The curative effect in treatment group was superior to that in control group(P<0.01). The total effective rate of treatment group was 94.2%，while the total effective rate of control group was 72.1%, and the symptoms and signs of treatmet group were obviously improved(P<0.01). The changes of function of left ventricl(SV, CO and LVEF) before and after therapy also had significant difference between treatment group and control group(P<0.01). Conclusion　The treatment combining enalapril with aldactone for chronic heart failure is more effective in the near future. This method is safe, cheap and convenient which is worthy of spreading to application in clinical work.]]> 2018/12/13 9:30:20 HUANG Zhong-guo, LI Jin-wei, SHAO Yong-jian, et al. 722true ［Abstract］　Objective　To study the clinical characteristics, pathological characteristics and treatment of cervical carcinoma in younger women(≤35 years old)with invasive cervical carcinoma.Methods　The clinical informations(clinical symptons, pathological characteristics, metastasis of lymph nodes and treatments) of 38 younger women(≤35 years old) with invasive cervical carcinoma who were treated from January 2003 to November 2008 (the study group) were retrospectively analyzed, and compared with 34 women (over 35 years) with invasive cervical carcinamoa in the same period(the control group).Results　There was an increasing prevalence of invasive cervical carcinoma in women under 35 years old.In the study group, the pregnancy and delivery times were lower, but the difference was not statistically significance（P>0.05）.The percentage of contact bleeding was higher in women in the study group and the control group, the main type was outside.Clinical stage was mainly the early stage and the percentage of Ⅱa were 94.7% (36/38)、91%(31/34) in the study group and the control group, but the difference was not statistically significance（P>0.05）.There were no significant differences between the study group and the control group in pathologic stage and grade, lymph node metastasis.Thirty-four patients in study group were treated while 30 of them were reserved one or two ovary and the ovaries were transplanted to the upper abdomen on the same side（P<0.05）.The pelvic lymph nodes in 31patiens of young women were cleared.The rate of metastasis was 22.5%, and the obturator lymph nodes was the first place to be metastasized.Conclusion　The prevalence of the cervical carcinoma tends to be younger.Attention should be paid to young women.Contact bleeding is a dangerous signal of cervical carcinoma in young women.And cervical carcinoma in young women can easily be misdiagnosised or not be diagnosised in young women.It is important keep attention to it in young women.Ovatian function in patients with earlier stage should be kept during opration.]]> 2018/11/7 8:23:04 ZHAO Ren-feng, LIU Yuan-yuan 721true ［Abstract］　Objective　To estimate the clinical effects in the treatment of patients with advanced malignant tumor with cytokine-induced killer （CIK）cells.Methods　CIK cells were induced with IL-2.γ-IFN.anti-CD3 monoclonal antibody and IL-1, then were transfused back to the patients with advanced malignant tumor after two weeks, for observation of effects, life quality, PFS, toxic reaction and the Karnofsky′s grade.Results　The effective rate and survival period of CIK group were significantly higher than that of control group.Conclusion　CIK cells therapy can enhance effect of the anti-cancer, improve survival quantity and prolong survival period, which probably can provide a potent immune therapeutic strategy for patients with advanced malignant tumor.]]> 2018/11/7 8:23:04 WANG Zhi-wei, GUAN Hong-mei 720true ［Abstract］　Objective　To investigate the clinical status of pregnant and parturient women with severe pre-eclampsia complicated placental abruption.Methods　A retrospective analysis was performed in 109 cases with placental abruption in our hospital from January 2006 to December 2008, the study group were 33 pregnant and parturient women with severe pre-eclampsia complicated placental abruption, the control group were 76 cases with placental abruption.Results　The average gestational weeks in study group was （32.54±2.11） weeks, there were no antepartum colporrhagia or suspicious placental abruption in nearly 90% cases.The average gestational weeks in control group was （37.62±4.73） weeks, the cardinal symptom was abdominal pain and external colporrhagia.There was significant difference between the two groups (P<0.05). but there was no significant difference in occurrence of delivery style and complication between two groups (P>0.05). The perinatal mortality in study group and control group were 25.7%(9 cases) and 9.9%(8 cases), respectively. There was significant difference between the two groups (P<0.05). Conclusion　Severe pre-eclampsia was important inducing cause of placental abruption, gestational age was main cause of affecting outcomes of perinatal infant. There is no direct relation between the occurrence of severe complications and severe pre-eclampsia in pregnant woman, Severe pre-eclampsia complicated asymptom placental abruption was more susceptible to cause severe adverse outcomes in pregnant and parturient women and perinatal infant, which should be vigilant and attached great importance.]]> 2018/11/7 8:23:04 LIAO Qi, LIANG Lan, WU Hua, et al. 719true ［Abstract］　Objective　To investigate the clincal significance of the expression of CD44v6 and Ezrin protein in colon cancer.Methods　Immunohistochemical method was used to examine CD44v6 and Ezrin protein of the sections from 47 cases of colon cancer and 20 normal colon tissues.Results　The positive rate of CD44v6 and Ezrin expression was 68.09%（32/47）, 74.47%(35/47) in colon cancer and was 25.00%（5/20）, 100.00%(20/20) in normal tissue. The CD44v6 and Ezrin positive rate of colon cancer with lymph nodes metastasis was significantly higher than that of colon cancer without (P<0.05).Besides, expression area of Ezrin was often in the cytoplasma for colon cancer and in the cell membrane for normal colon tissues.Conclusion　The results suggest that detecting the expression of protein Ezrin and CD44v6 is helpful to judge malignancy degree and metastasis potentiality of colon carcinoma. The protein Ezrin is hoped to be a new index to judge prognosis.]]> 2018/11/7 8:23:04 LU Xiao-min, PENG Chun 718true ［Abstract］　Objective　To explore the types and distribution of HPV genes in female condyloma (CA) patients infected with human papilloma virus(HPV).Methods　Fluorescence quantitative polymerase chain reaction (FQ-PCR) was used to detecte the typos of HPV genes in wart tissue or secretion from 256 CA patients.Results　HPV_{6, 11} type-positive rate was 93% (238/256), HPV_{16, 18} type-positive rate was 15.2% (39/256), both positive rate of HPV_{6, 11} and HPV_{16, 18} was 10.9% (28/256). Quantitative detection of viral load showed, the maximum viral load was1.0 × 10⁸ copies/ml, with a minimum of 2.2 × 10⁴ copies/ml.Conclusion　The patients with condyloma in this region were mainly infected by HPV_{6, 11} low-risk type, with a small number fo HPV_{16, 18} high-risk type. Fluorescence quantitative PCR detection technique, with high sensitivity, specificity and detection characteristics of a short time, can timely and accurately provide a reliable basis for the clinical treatment and the prognosis of patients with HPV.]]> 2018/11/7 8:23:04 QIN Gui-fang, LIU Xin, ZHAO Lin 717true ［Abstract］　Objective　To study the causes of cesarean section in the parturient born after 1980s, in order to master the indications of cesarean section correctly and ensure the safety of mathers and babies.Methods　The compositions of causes of cesaren section in hospital delivery parturients in our hospital from Janurary 2004 to December 2008 were analyzed retrospectively.Results　The total number of deliveries in the five years was 5 232 cases, included 1 200 cases(22.9%) underwent cesarean section and 4 032 cases (77.1%) adopted natural delivery.The cesarean section rate increased progressively during the five years (P<0.01).The number of hospital deliveries in parturients born after 1980s was 1 300 cases, included 799 cases (61.5%) underwent cesarean section and 501 cases (38.50%) adopted natural delivery.The cesarean section rates in the parturients born after 1980s and parturients not born after 1980s increased progressively (all P<0.05).The cesarean section rates in parturients born after 1980s were maitained at a relatively high level (55.6%～68.5%;mean 61.5%).The cesarean section rates of each year during the five years in parturients born after 1980s were highter than those in parturients not born after 1980s (all P<0.01).In the first three causes of cesarean section in parturients born after 1980s, the social factors was the first place (436 cases, 54.6%);the causes related to fetus was the second place (264 cases, 33.0%);the maternal factors was the third place (99 cases, 12.4%).Conclusion　Cesarean section rate increased mainly due to social factors.In order to reduce the cesarean section rate, in addition to physicians strictly master the indications of cesarean section, the whole society should be concerned about the problem of cesarean section increased year by year.]]> 2018/11/7 8:23:04 HUANG Hui-xiu 716true ［Abstract］　Objective　To analyse the cause of refractory periapical periodontitis and evaluate the clinical effect.Methods　One hundred and seventy-two patients with refractory periapical periodontitis were treated by symptomatic treatment. The effects were evaluated after one year.Results　One year later, the reexamination results showed that 166 cases succeeded, and 6 cases failed. Effective rate was 96.5%.Conclusion　To analyse and find out the cause of refractory periapical periodontitis, giving improved etiological treatment, and the cure rate will be high.]]> 2018/11/7 8:23:04 CHEN Yan, LI Shi-jian, FA Ping, et al. 715true ［Abstract］　Objective　To observe the decompression effect， adverse reaction and metabolism effect of nifedipine sustained-release tablet combined with enalapril.Methods　Ninety-six patients with hypertension were randomly divided into treatment group and control group，in which there′s 48 patients respectively, the patients in treatment group were treated with nifedipine sustained-release tablet combined with enalapril, and only enalapril were given in control group, this course of treatment was 4 weeks, their blood presure were measured by the same doctor from beginning to end, and the blood sugar, blood-lipid, electrolyte, hepatic function and renal function before and after treatment were determined, and also did electrocardiogram.Results　After treatment for four weeks，the effectiveness rate of treatment group and control group were 45.8 percent and 25.0 percent respectively， and the total effective rate were 95.8 percent and 68.7 percent respectively. There were significant difference between the two groups(P<0.05 or P<0.01), and no effects on glycometabolism, lipid metabolism, electrolyte, hepatic function, renal function and electrocardiogram of the two groups.Conclusion　There is very good effects of nifedipine sustained-release tablet combined with enalapril on the decompression, with less side effect，it is well worth widely using in clinic.]]> 2018/11/7 8:23:04 HUANG Shang-neng 714true ［Abstract］　Objective　To study the feasibility of clinical application of micro-invasive implanted radial ¹²⁵I particle in unresectable splanchnocoel malignant tumors. Methods　Retrospective analysis was applied in 96 cases with stage Ⅲlung cancer, or intermediate(advanced) hepatocellular carcinoma/pancreatic carcinoma who had been treated with micro-invasive implant radiotherapy guided by brightness mode, CT and endoscope.Results　After treatment, within 96 cases, there were 19 cases of complete remission, 39 of partial remission, 21 of non-remission and 17 of progression. The life quality of patients was improved, and there was no transfer or discharge of radioactive particles in vitro. The follow-up investigation of patients for 1～5 years showed that 39 cases died and 57 cases survived, some of which had reached the maximum 5 years after treatment.Conclusion　The micro-invasive implant radial ¹²⁵I particle shows a good therapeutic efficacy in unresectable splanchnocoel malignant tumors of intermediate and advanced stage.]]> 2018/12/3 8:39:12 TANG Li, HAN Wei, SUN Xin 713true ［Abstract］　Objective　To study the pain outcome and vertebral body height restoration in treatment of osteoporotic vertebral compression fractures (VCF) by kyphoplasty.Methods　The data of 12 patients treated with kyphoplasty were retrospectively reviewed. A total of 19 vertebral levels were augmented.Visual analog scale (VAS) scores were documented in the immediate pre- and postoperative period, as well as 4, 12 weeks after the procedure. Vertebral body height restoration was assessed on postoperative X-rays.Results　Mean preoperative VAS score was 9.3 and improved to 5.4 in the immediate postoperative period. At 4, 12 weeks postoperatively, mean VAS scores were 5.1, 5.9 respectively. All patients returned to their daily activities within 24 hours. Vertebral body height restoration was obvious in the anterior and middle portion of the vertebral body.Conclusion　In regards to pain relief and postoperative functional outcome, kyphoplasty is a safe and effective treatment modality for osteoporotic VCFs.]]> 2018/12/3 8:39:12 WANG Yu, LIU Xian-yin, GUO Jian-en, et al. 712true ［Abstract］　Objective　To analyse the cause, diagnosis, treatment, prognosis and prevention of primary simple brainstem hemorrhage.Methods　The clinical data of 42 patients with primary simple brainstem hemorrhage were retrospectively analysed.Results　The ages of high incidence ranged from 50 to 67 years;28 cases had history of of hypertension. There were 33 cases of elevated blood pressure (78.57%) at onset of the diseases.Pontine hemorrhage was the most common in brainstem hemorrhage(76.19%). When amount of bleeding was less than 2 ml, the clinical manifestations was atypical, with best prognosis(cure rate 100%);when amount of bleeding ranged between 2 ml and 5 ml, the clinical manifestations was typical, and the fatality rate was lower (22.22%), with good prognosis;when amount of bleeding ranged between 5 ml and 10ml, the fatality rate was high (77.78%), with poor prognosis;the fatality rate was highest(100%) when amount of bleeding was more than 10 ml.Conclusion　The onset of primary simple brainstem hemorrhage was acute, with severe disease, the mortality is high, and the prognosis is poor.Hypertension is main etiological cause of the primary simple brainstem hemorrhage.CT is a safe and reliable diagnosis method to primary simple brainstem hemorrhage.As early as possible carries on the tracheotomy and hypothermia treatment can effectively enhance the curative effect and reduce the mortality and the deformity rate.The strict control blood pressure is an important measure that prevents the primary simple brainstem hemorrhage. Bleeding site, bleeding volume, as well as the degree of brain stem dysfunction and the condition of systemic organ function is the key to predicting the prognosis.]]> 2018/12/3 8:39:12 SHANG Guan-wen 711true ［Abstract］　Objective　To detect the expression of PTEN, Cyclin D1 and CDK4 in oral squamous cell carcinoma (OSCC) and analyze the relationship between PTEN, Cyclin D1 and CDK4.Methods　Immunohistochemical staining by SP method was used to detect the expression of PTEN, Cyclin D1, CDK4 in 60 cases of OSCC, 25 cases of dysplasia, 15 cases of simple hyperplasia, and 10 cases of normal oral membrane.Results　The negative or low expression of PTEN in OSCC group was 21.8%, which was significantly lower than that in normal, simple hyperplasia and dysplasia group. The positive expression of Cyclin D1 and CDK4 in most of OSCC group were observed, which was 53.3% and 100%, respectively, and was much higher than those in normal, simple hyperplasia and dysplasia group. The negative correlation between PTEN with Cyclin D1 and CDK4 and the positive correlation between Cyclin D1 and CDK4 were observed.Conclusion　Our findings suggest that the tumor suppress gene PTEN may play a role in the pathogenesis of OSCC. In OSCC, PTEN may down-regulate the expression of Cyclin D1/CDK4, which results in the suppression of cell growth.]]> 2018/12/3 8:39:43 CHEN Hong-ying, XIE Shi-ming 710true ［Abstract］　Objective　To evaluate the clinical value of loop electrosurgical excision procedure（LEEP）in treatment of chronic cervicitis.Methods　A retrospective analysis of the clinical data was carried out in 161 patients with chronic cervicitis underwent LEEP from August 2006 to December 2007.Results　The cure rate was 80.1%（129/161）four weeks after LEEP, the cure rate was 97.5%（157/161）eight weeks after LEEP.The mean operative time was（11±3.8）min, and the mean operative blood loss was（10±1.5）ml.Conclusion　LEEP is a simple, safe and effective procedure for patients with chronic cervicitis.There is double effect of diagnosis and therapy of LEEP in the treatment of chronic cervicitis.]]> 2018/12/3 8:39:43 YU Shan-zhi, MA Gang, CHEN Chang-yi, et al. 709true ［Abstract］　Objective　To investigate the natural outcome and the related risk factors in subjects with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). Methods　During April 2006 to June 2006, 79 subjects with IFG and IGT, who had been diagnosed as abnormal glucose metabolism based on a diabetes mellitus census of 1 062 citizens in Chaoyang city from April 2003 to June 2003, were examined with height, weight, waist circumference, blood pressure, and 75 g oral glucose tolerance test (OGTT). Meanwhile, serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were also tested.Results　Of the 65 subjects 22 subjects had diabetes mellitus(DM). Among them the conversion rates to DM were 10.8 %, 9.2 %, and 10.4% for the subjects with I-IFG, I-IGT, and IFG/ IGT, respectively. With the age increasing, abnormal glucose metabolism, hypertension, obesity and abnormal lipid metabolism became much severer. Incidence of abnormal glucose metabolism obviously increased in the subjects aged above 40 years. The results of mono-factor analysis showed that glucose increase may be related to the aging, DM family history, work intensity, increase of waist circumference and systolic blood pressure, abnormal blood fat. Logistic regression found that aging, central obesity， hypertension and less physical work were all the risk factors of DM. Conclusion　Cumulative life-incidence of DM in the subjects with I-IGT, IGT/IFG is significantly higher than that in the subjects with I-IFG. Aging, central obesity, hypertension and less physical work are the main risk factors of abnormal glucose metabolism. Therefore, it is essential to control blood pressure and body weight and enhance physical exercise in order to prevent from DM.]]> 2018/12/3 8:39:43 ZHANG Hai-guang, WANG Yan, WANG Xu-hui 708true ［Abstract］　Objective　To investigate the clinical efficacy of single open door laminoplasty with lateral mass screw fixation and bone graft for the treatment of cervical spinal cord compression.Methods　From February 2004 to June 2008, the single open door laminoplasty with unilateral lateral mass screw fixation and bone grafting was used to treat 26 patients with cervical spinal cord compression, including 18 male patients, 8 female patients ; aged 51 to 67 years old ; the average age was 58 years old. Among 26 patients, there were 22 patients suffered multi-segmental cervical spondylotic myelopathy(three or more than three segments). Of them 10 patiens complicated with developmental spinal stenosis, 6 patients with power spinal stenosis, 3 patients with ossification of posterior longitudinal ligament, one case was traumatic. Another 4 patients suffered from the cervical spinal canal tumor. Follow-up time was 9 months to 26 months, with an average of 20 months. Results　The efficacy were evaluated by reference to Japan Association of Plastic Surgery (JOA) score standards. There were excellent in 8 patients, good in 15 patients, fair in 2 patients, poor in 1 patient, the excellent and good rate was 88.5%. No patient had vascular injury or internal fixator fracture, one patient with meningioma occurred spinal cord ischemia-reperfusion injury ofter operation due to too large tumor， the disease cordition was improved by active treatment, and had self-care ability.Conclusion　The method can be applied to the patients with cervical spinal cord compression required to carry out posterior, and its efficacy is positive. The advantage is the relative safety of surgery, simultaneous performance of a thorough decompression and a strong fixatiom. It is applied particularly to treat the patients with cervical spondylotic myelopathy complicated with segmental instability.]]> 2018/12/3 8:39:43 XU Peng-yong, LING Shang-zhun, CHEN Jun, et al. 707true ［Abstract］　Objective　To discuss curative effect of live bifidobacterium tablet retention enema in treatment of children patients with rotavirus enteritis.Methods　One hundred and eighty children patients with rotavirus enteritis were randomly divided into two groups.Both groups accepted the same treatment and only the routes of administration for live bifidobacteium tablet were different(orally and retention enemaly, respectively). All the treatments lasted for 3～7days.The extinction time of clinical manifestations was observed for all patients with their curative effects compared between two groups.Results　After 72 hour treatment，the excellence rate of therapy group and control group was 82.22% and 57.78% respectively（P<0.01）.Compared with control groups，live bifidobacteium tablet retention enema could obviously shorten remedy times of symptoms and hospitalization days（P<0.01）.Conclusion　The treatment with live bifidobacterium tablet retention enema on children patients with rotavirus enteritis can improve the excellence rate, ease the disease and shorten the course of treatment.]]> 2018/12/3 8:39:43 WU Qi-fu 706true ［Abstract］　Objective　To observe the effect of simvastatin on the soft plaque of carotid atherosclerosis.Methods　Three hundred patients with carotid atherosclerosis were randomly divided into two groups and each group had 150 patients， respectively. The control group treated by clopidogrel(75mg qd) and the treatment group added simvastatin (20mg qn) besides clopidogrel. All patients rechecked by color doppler ultrasonography after 6 months′of treatment， then the variation of the carotid atherosclerosis in two group were compared.Results　The soft plaque of carotid atherosclerosis in the treatment group had more incidence of extinction， decreasing or stabilization of soft plaque than control group.Conclusion　Simvastatin can reverse and stabilize the belt plaque of carotid atherosclerosis.]]> 2018/12/3 8:39:43 ZHOU Te-fei, ZHANG Kui-hua, YIN Wei-qun 705true ［Abstract］　Objective　To observe the clinical effect and safety of lovastatin in the treatment of 72 hyperlipidemia patients.Methods　One hundred and forty-four hyperlipidemia patients were randomly divided into observation group (72 patients) and compared group (72 patients). The patients in observation group were treated with lovastatin, while those in the compared group were not treated with drugs.Results　The total efficiency rate of observation group was 88.9%. The TC, TG, LDL-C, LDL/HDL of observation group after treatment were better than that of compared group (P<0.05). There was no distinct toxic and side effects.Conclusion　Lovastatin treating the hyperlipidemia has good effect and safety.]]> 2018/12/3 8:39:43 WANG Qiu-juan, DONG Huo-lin, HE Wei-feng 704true ［Abstract］　Objective　To investigate the therapeutic efficacy of kushenin and polyinosinicacid-polycytidylic acid in the treatment of chronic hepatitis B and hepatic cirrhosis.Methods　One hundred and twenty-nine chronic hepatitis B patients or hepatis cirrhosis patients with positive HBV-DNA, and abnormal liver function were randomly selected, and were treated by intra-muscular injection of kushenin and polyinosinicacid-polycytidylic acid，combined with liver-protecting treatment.The regular observation of liver function, HBV-DNA, hepatobiliary B-ultrasound examination were performed. The patients were observed for over one year after drug withdrawal.Results　The clinical efficiency rates whose liver function was recovered to the normal level after 1 course of treatment was 89.1%. the HBV-DNA negative conversion rate at the end of treatment was 61.2%. For the patients with positive conversion of HBV-DNA during one year withdrawal poriod, the retreatment was still effective.Conclusion　Kushenin and polyinosinicacid-polycytidylic acid combined with liver-protecting and enzyme reducing treatment has obvious short-term efficacy on anti-HBV. With treatment prolonged, HBV-DNA negative conversion rate will increase and recurrence was observed in withdrawal period, however the retreatment will be still effective.]]> 2018/12/3 8:39:43 LU Yi-min 703true ［Abstract］　Objective　To study the feasibility and validity of maintenance hemodialysis for the senile uremic patients.Methods　Thirty-seven patients above the age 75 with chronic renal failure were treated by hemodialysis.The clinical results and causes of death were retrospectively summarized and analysed.Results　Hemodialysis can effectively prolong the life of senile uremic patiens.The main factors of the death were cardiaovascular diseases and infection.Among the patients surviving for 12 months or more, the age of beginning hemodialysis were younger, the endogenous creatinine clearance rate and plasma proteins level were higher, the severity of anemia was relatively lighter, while the nutritinal status during dialysis was better and the angiocardiopathy and other complications were fewer as compared with patients surviving for less than 12 months (P<0.05）.Conclusion　The analysis indicated that the age before dialysis, the diabetes as primary disease, the occurrence of angiocardiopathy or secondary infection during dialysis, the plasma albumin level, the correction efficacy of anemia，etc. were independent risk factors on hemodialysis in senile patients.Hemodialysis is an effective way of treating patients over the age 75 with chronic renal failure.]]> 2018/12/3 8:39:43 MENG Lu-dan, LU Da-hai 702true ［Abstract］　Objective　To probe into the revival effect contrast between two groups patients who was extirpated vocal cords nubble under support laryngoscope.Methods　Sixty-six patients with vocal cords nubble were randomly divided into A and B group, 33 patients in each group. A group was used full anaesthesia inducement in fentanly, propofol, midazolam; B group used full anaesthesia inducement in fentanly, propofol, lidocaine, the drug of muscle flab was attacurium in the two groups. The minim pump drug of vein maintain was propofol, fentanly, the drug was stopped after operation.Results　The anaesthesia effect was same in the two groups.Compared with B group, the revival time and the time of pulling out tube were faster in A group. Conclusion　The operation of extirpated vocal cords nubble under support laryngoscope which use midazolam can influence the revival time of the patients, the use of doxapram can accelerate the revival rapidity of patients.]]> 2018/12/3 8:39:43 WANG Jing-qiang, LI Zhan-ling, PENG Li-li, et al. 701true ［Abstract］　Objective　To study the Effects of metformin(MTF) in treatment of infertile patients with polycystic ovary syndrome (PCOS) complicated with insulin resistance(IR).Methods　Forty-two PCOS with infertility divided into two groups.Study group(n=22) took metformin for three months, then took Clomiphene citrate for three cycles if they were not pregnant.Control group(n=20) were given Clomiphene citrate (CC) for three cycles. The ovulation rate and pregnancy rate and the change of subjects including Testosterone（T）、fasting insulin (INS)、baric index (BMI)、blood fat and so on were obserred.Results　In study group, 14 patients (64%)resumed ovulation and 11 patients(50%) got pregnancy, no abortion.The levels of T、INS、BMI were significantly decreased (P<0.05) after three months treatment，the level of blood fat had no significantly diference (P>0.05). In control group, 13 patients (65%)resumed ovulation and 6 patients(30%) got pregnancy, no abortion. The levels of BMI、INS、T、blood fat have no significantly diference (P>0.05) after three months treatment.Conclusion　Metformin therapy not only improves pregnant rates but also decreases high T、BMI levels and insulin resistance，and it′s security，saveing money，convenient.]]> 2018/12/3 8:39:43 WEI Jing 700true ［Abstract］　Objective　To discuss the application and effect of buttocks island shape fascivcataneous flap in the repair of sacrococcygeal pressure sore. Methods　According to the donor anatomical characteristis and the recipient damaged situation, taking superior gluteal as the rotatory point, four lobate island shape fasciocataneous flap were designed.The depth of got flap reached the deep fascia, but did not damage the gluteus maximus, the flap was rotated 90 degree to repair injured areas.Then the donor area were won over and sutured.Results　From 2000 years to 2008 years the clinical practice were performed in 14 patients, after the technique the flap completely survived, the quality of flap was soft, the appearance of flaps was satisfied.Conclusion　The clinical effect of the buttocks island shape fasciocataneus flap in the repair of sacrococcygeal pressure scors is satisfied.its appearance is full, also does not affect the activity of the hip joint.]]> 2018/12/3 0:00:00 QIU Fu- kui, LIAO Wen-lun, ZHU Li-juan 699true ［Abstract］　Objective　To study the clinical value of radionuclide pulmonary perfusion imaging in pulmonary embolism disease. Methods　Radionuclide pulmonary perfusion imaging was　performed in 21 patients clinically suspected pulmonary embolism. Results　Multiple segments of abnomal blood perfusion were found in 13 of 21 patients, among them, radioactivity defects areas were found in 19 segments, radioactivity rarefied areas were found in 48 segments.Conclusion　Radionuclide pulmonary perfusion imaging is a non-invasive and effective method in diagnosing pulmonary embolism.]]> 2018/12/6 0:00:00 ZHU Mei, ZHANG Bing, WU Guo, et al. 698true ［Abstract］　Objective　To evaluate the significance of detection of proliferation cell nuclear antigen (PCNA) protein expression in exfoliated cells in pleural fluid for the diagnosis of lung cancer. Methods　The exfoliated cells in pleural fluid were collected from 48 patients with lung cancer, 40 patients with benign diseases. Immunohistochemical method and the cytologic analysis were carried out simultaneously, and the 2 detection results were compared. Results　PCNA from pleural fluid exfoliated cells had lower specificity (71.20%) than that of cytologic analysis(91.34 0%)P<0. 05, but its sensitivity (100.00%) significantly higher than that of cytological examination (82.20%)P<0.01.The expression of PCNA protein in pleural fluid exfoliated cells from patients with lung cancer, and that in patients with diseases were 78.26%, 32.34% respectively. The expression positive rate of PCNA protein in higher grade lung cancer was greater compared with that in lower grade cancer(P<0.05);but it was not related to differentiation and pathological type.Conclusion　PCNA protein detection by immunohistochemical method has potential value for the early diagnosis, routine screening and postoperative monitoring of lung cancer.]]> 2018/12/6 8:49:55 LU Xiao-min, PENG Chun 697true ［Abstract］　Objective　To explore the curative effects of anal reconstruction in situ preserving sphincter ani externus for low rectal carcinoma.Methods　Twenty-three patients underwent anal reconstruction in situ preserving sphincter ani externus(ASRP group) was compared with 31 patients underwent Miles operation(Miles group).Analysis was conducted on local recurrence rate, 5-year survival rate， and fecal control function between the two groups.Results　The local recurrence rate of ASRP group and Miles group was 26.1% and 25.8% respectively, the 5-year survival rate of the two groups was 60.5% and 59.3% respectively, and there was no significant difference between the two groups(P>0.05). The fecal control function of patients in ASRP group improved gradually and after 12 months there was no patients occuring fecal incontinence.But the patients of Miles group had not fecal control function and their times of defecation was more than that of ASRP group.The patients of ASRP group had better postoperative fecal control function than Miles group (P<0.05). Conclusion　Anal reconstruction in situ preserving sphincter ani externus for low rectal carcinoma has advantage treatment effects and achieves good fecal control function.]]> 2018/12/6 8:49:55 TAN Dong-xin 696true ［Abstract］　Objective　To understand the characteristics of changes of the serum cholinesterase(CHE), prealbumin(PA), supersensitive reactive protein C (hsCRP) and reactive protein C (CRP) in the children with sepsis and their clinical significances, and to approach the changes and their effects on the prognosis of the sepsis in children.Methods　From January, 2007 to February, 2009, 59 cases of sepsis in accord with diagnostic criteria underwent treatment of primary affection, respiratory sustentation, fluid anabiosis, vasoactive agent, anti-infection and symptomatic treatment, etc. And according to prognosis of disease, the cases were classified into one not-yet-recovered/expired group of 18 cases and one cured/survived group of 41. In all of the cases, on the day when into the groups and the third day, their serum CHE, hsCRP, CRP and indexes of liver function were detected. Serum PA of 49 cases was detected simultaneously，and a control group of 30 cases of the same age with pneumonia was set up.Results　Compared with the levels of the serums CHE and PA of the cured/survived group, those of the not-yet-recovered/expired group with sepsis dropped remarkably (respectively P<0.05 and P<0.01) on the day entering the group and the third day, while the hsCRP and CRP rose remarkably(respectively P<0.05 and P<0.01). Compared with the serum CHE and PA of unimpaired children, those of the two groups both dropped remarkably (P<0.01); hsCRP of the not-yet-recovered/expired group increased more than the control group (P<0.01); CRP of the cured/survived group and the not-yet-recovered/expired increased more than the control group(both P<0.05).Conclusion　There are differently lower levels of serums CHE and PA and higher hsCRP and CRP in the impaired children with sepsis. Serums CHE, PA, hsCRP and CRP are indicative of the severity of the patient′s condition with sepsis, which are of referred value to the prognosis of the child with sepsis.]]> 2018/12/6 0:00:00 MO Wu-gui, WEI Rong, SHE Shang-yang, et al. 695true ［Abstract］　Objective　To analyses the risk factors of diabetic foot, in order to direct clinical doctors to screen the patient with high risk factors of diabetic foot (DF), discover DF early, prevent and cure it early, which has the important significance in decreasing the morbility of DF and amputation.Methods　The clinical data of 23 in patients with DF (DF group) hospitalized in endocrine department and 85 in diabetic patients (NDF group) hospitalized in the same period were collected.The data was observed including sex, age, the duration of disease, BMI, SBP, DBP, the history of hypertension and smoking, complication of diabetic nephropathy (DN), diabetic retinopathy (DR), coronary artery disease (CHD) and cerebral infarction (CI), TG, TC, low density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG), postprandial blood glucose (PBG), glycosylated hemoglobin (GHbA1c).Results　Compared with the NDF group, the patients′ age was older and the duration of diabetes was longer in DF group (P<0.05), proportion of male was also different (P<0.05), the rate of somking was no significant difference (P>0.05).Patients who complicated with CHD, DN and DR were more in DF group (P<0.05), the morbidity of hypertension and CI were no significant difference between the DF group and the NDF group (P>0.05).Compared with the NDF group, FBG and GHbA1c were higher in the DF group (P<0.05), the level of blood lipid (including TG, TC, LDL-C, VLDL-C) and PBG had no significant statistical difference (P>0.05). Man、SBP、GHbA1c were the risk factors of DF according to the logistic regression analysis. Conclusion　It was an important measure to prevent type 2 DM in community population to propose healthy life style including proper diet, control of blood glucose and blood pressure.]]> 2018/12/6 8:49:55 WU Jun-wei, LING Jun-hong, WANG Fu-yu, et al. 694true ［Abstract］　Objective　To discuss the economic effects of different therapeutic schemes of the same illness.Methods　One hundred and ten patients with peptic ulcer were randomly divided into three groups：A、B and C groups. All patients took drugs oral daily, and the treatment course of every patient was two week. The data was evaluated with cost-effectiveness analysis. Results　The costs of three groups were (following order: A、B、C group) 44.80、233.38 and 338.24 yuans respectively. The ulcer healing rate were (following order: A、B、C group) 72%、91% and 92.6% respectively. Conclusion　Group B is considered to be the best drug treatment project.]]> 2018/12/6 8:49:55 DU Ya-ming 693true ［Abstract］　Objective　To study the prognosis of neonates with hyperbilirubinemia treated by exchange transfusion, for accumulating clinical experience and directing the clinical work.Methods　Forty-three exchanged transfusion neonates with hyperbilirubinemia were observed as observation group. Another 43 patients which were treated by routine methods as control group. Their hearing, development and psychomotor function were observed.Results　The improvement of hearing, development, psychomotor function in the observation group were better than in the control group. Conclusion　Treatment of exchange transfusion can improve the neonate prognosis. The treatment of exchange transfusion is worthy of being recommended in neonates with hyperbilirubinemia.]]> 2018/12/6 8:49:55 TANG Shang-ying 692true ［Abstract］　Objective　To obserre the effect of nutritional support treatment on chronic obstructive pulmonary disease (COPD) patients with malnutrition intravenous.Methods　Sixty COPD patients were divided into the control group (26 patient) and nutrition group （34 patients）, the control group given anti-infection, spasmolysis, relieving asthma, and other conventional therapy, while nutrition group, on the basis of the conventional therapy received nutritional therapy, the daily calorie supply was figured out, according to the basis energy consumption（BEE）, then glucose, amino acid compound, albumin, multi-vitamin were used by enteral and parenteral ways for two weeks. Results　VC, FEV1, MMEF, MVV and other conventional indicators of lung function in nutrition group were improved more significantly than that in the control group (P<0.05). Conclusion　For patients with COPD using nutritional therapies as soon as possible can improve the state of malnutrition and the quality of life of patients, the clinical effect is remarkable.]]> 2018/12/6 8:49:55 ZHOU Bin 691true ［Abstract］　Objective　To investigate the efficacy and safety of azithromyci in treatment of children with mild and middle community-acquired bacterial pneumonia.Methods　Seventy-four patients were randomly divided into the treatment group and the control group.The patients of the treatment group(n=34) received the treatment with oral azithromycin in a dose of 5mg/kg, one time daily for 5～7days;the patients of the control group (n=40) received the treatment with intravenous drip of augmentin in a dose of 30mg/kg, two time daily for 5～7 days.Results　A satisfactory clinical response (the cured plus the improved)was achieved at the rate of 85.3% and 80.0% repectively in the treatment with azithromycin and augmentin(χ²=0.36, P>0.05).Conclusion　These results indicate that azithromycin is effective and safe in the treatment of children with mild and middle community-acquired bacterial pneumonia.]]> 2018/12/6 8:49:55 CHEN Qi-tang 690true ［Abstract］　The pediatric laparoscopic operation is applied more and more extensively in the clinical practice.Its effects on liver function is very complex because the carbon dioxide gas is used for the establishment of pneumoperitoneum during this operation. The main reason is blood stream tranafer of liver portal vein which is influenced by gas abdomen′s pressure 、operation duration、operation style etc.The research present situation on the effects of laparoscopic operation on liver function will be summarized in this article.]]> 2018/12/6 8:50:23 LIAO Gui-rong 689true ［Abstract］　Bacillus calmette-guerin ribonucleic acid is a newtype of non-specific immunity regulatire drug, and has been widely used in clinic. This article reviews the advances of clinical application of bacillus calmette-guerin ribonucleic acid in the children asthma attack, henoch-schonlein cough, recurrant respiratory tract infection, chronic obstructie pulmonary disease(COPD), chronic pulmonary heart disease, pulmonary tuberculosis, tuberculosis pleurisy, late pulmonary carcinoma and immunity pathergy disease, etc.]]> 2018/12/6 8:50:23 ZHOU Yu-cheng, ZHOU Ya-li 688true ［Abstract］　The neuroprotection of mild hypothermia has been proved. With the advanced study of neuroprotection of mild hypothermia in recent years, the clinical application of mild hypothermia becomes wider and wider. This report summarizes mlid hypothermia therapy and its application in critical-severe neural system diseases.]]> 2018/12/6 8:50:23 QIN Hua-hong, LI Chun-xiang, QIN Jian-mei, et al. 687true ［Abstract］　The immunosuppressants play an important role in the using of curing NS. This paper describes the mechanism treatment and principle of immunosuppressants, so that we can make better usage of immunosuppressants in clinical practice, not only achieve a better effect, but also reduce the side effects of the drug.]]> 2018/12/6 8:50:23 MENG Hai-qiang, WANG Ling 686true ［Abstract］　Heart rate turbulence (HRT) is a new electrophysiological method to appraise the cardial automatic regulative function. It was discovered that HRT had higher value in forecasting and evaluating the danger of heart disease. It will reflect the change of the automatic nervous function through the change of the ventricular pressure after ventricular premature complexes.There is compact relation between the incident of heart disease and HRT.]]> 2018/12/6 8:50:23 TANG Wen-hong 685true ［Abstract］　As a kind of the important protein that secreted by fat cell, adiponectin is abundant in serum. Concentration decrease of adiponectin has close relations with diabetes and the trunk complication of diabetes.Adiponectin has function of cutting down the blood sugar level, improving insulin sensitivity, protecting blood vessel endothelium and resisting the vascular sclerosis.So adiponectin has extensive application prospects in treatment of diabetes and its complications.]]> 2018/12/6 8:50:23 XUN Jing-qiong, SU Ke 684true ［Abstract］　The intrahepatic bile duct lithiasis is a common disease and refractory biliary duct disease in our country.B-ultrasound examination is used for liver bile duct lithiasis diagnosis in early time.The combination examination of B- ultrasound, CT and/or the MRI mainly should been used for preoperative localization;The treatment should been performed in early time, also its tendency is surgical operation.The principle are to remove the focus of infection, take out completely stone, correct narrow retain, unobstructed drainage, prevent and control recrudescence.The surgery should been performed by means of using the individuation treatment plan and selecting appropriate surgery method.It is possible effectively to reduce the residual stones and the recurrence rate by the combination application of endoscope and microinvasive techniques during and affer operation.This article reviews the relevant literature and makes a summary report.]]> 2018/12/6 8:50:23 LAN Zhi 683true ［Abstract］　This article, from the aspects of the principle and the composition of the computed radiography and digital radiography, reviews the status quo of digital X-ray imaging technology and its clinical applications.]]> 2018/12/6 8:50:23 ZHONG Yi, MA Long-bai 682true ［Abstract］　The etiologies of neonatal pulmonary hemorrhage are many，the research advances of the pathogenesis of neonatal pulmonary hemorrhage are summarized in this article.]]> 2018/12/6 8:50:23 FENG Jian-hua, CHEN Qi-tang, PANG Yu-sheng 681true ［Abstract］　Diabetic peripheral neuropathy（DPN）is a most common and troublesome complication of diabetes mellitus.This paper reviewes the clinical status of DPN treated by applying western medicine、physical therapy of modern medicine and traditional chinese medicine in the recent years.]]> 2018/12/6 8:50:23 SUN Peng-fei 680true ［Abstract］　This paper reviews CT techniques, CT manifestations and pathologic basis of the abdomen lymphadenopathy. The abdomen lymphadenopathy has tuberculosis, lymphoma and metastasis etc. Tuberculous adenopathy commonly shows lymphadenectasis, peripheral enhancement, frequently involved extent relating to the infection routes of abdomen tuberculous.Lymphomatous adenopathy often shows homogeneous enhancement, a few accompany necrosis, sometimes lymphadenectasis encased vessel as “sandwich”, frequently involved the upper and lower paraaoratic lymph nodes.Metastasis lymphadenectasis mostly shows mixed or inhomogeneous enhancement, and the anatomic distribution relating to the draining course of the lymphatics.]]> 2018/12/6 8:50:23 FANG Hua-sheng, MA Long-bai 679true ［Abstract］　Color Doppler techniques include Color Doppler Image Formation (CDFI) and Color Doppler Energy Image(CDE).The combining application of the two techniques can provide the accurate information for the kidney diseases and the blood perfusion situation in kidneys. In this article, the progresses on color Doppler ultrasound in the examination of the kidney diseases are shown.]]> 2018/12/6 8:50:23 KANG Li-ke, WANG Xiao-yan 678true ［Abstract］　Bacterial vaginosis (BV) is a syndrome which lacks symptoms of vaginal mucositis caused by the imbalance of vaginal microflora, overgrowth of anaerobic bacteria and Gardnerella bacteria, and inhibition of facultative anaerobic lactobacillus in the vagina. It is one of the most common diseases of gynecology which causes serious harm to women′s reproductive system. The diagnosis of BV depends on laboratory testing. Here the research progress of laboratory testing of bacterial vaginosis is reviewed.]]> 2018/12/6 8:50:23 LI Ji-hui 677true ［Abstract］　The effect of blood glucose fluctuations and diabetes oxidative stress on damage of target organs and its complications is becoming the new hot spots in the prevention and treatment in diabetes.There is a close relation between the oxidative stress produced by blood glucose fluctuations and the occurrence and development of diabetes and its complications.Therefore reducing the effect of blood glucose fluctuations on diabetes oxidative stress and reversing the damage of oxidative stress on cells and tissue can prevent or delay the development of diabetes and its complications. This article is a review on this subject in published literature in recent years.]]> 2018/12/6 8:50:23 PENG Yun-bo, YAN Xiao-dong 676true ［Abstract］　Maspin is a tumor suppressor gene, and it plays on important role in tumor invasion and metastasis, angiogenesis and the combined action with other tumor suppressor gene, this paper describes the reseach development on Maspin in the occurrence and development of gastric cancer.]]> 2018/12/6 8:50:24 WANG Zi-xi 675true ［Abstract］　Invasive fungal infections (IFI) have become an increasingly prevalence and recognised as major complications in critically ill patients due to the advent of increasing elderly population, broad-spectrum antibacterial therapy, immunosuppressant therapy, organ transplantation, increasing AIDS patients and other factors such as invasive intubation and catheterization. The epidemiology and clinical features, diagnosis and treatment of IFI are reviewed, together with the mechanisms of IFI and drug-resistance during treatment.]]> 2018/12/6 8:50:24 XIONG Bin 674true ［Abstract］　Adiponectin is an important protective cytokines.This article reviews the progressions about the relationship between adiponcetin and several digestive system diseases (acute liver injury, fatty liver, liver fibrsis, gastric and intestines cancer).]]> 2018/12/6 8:50:24 HE Shan-shou 673true ［Abstract］　Lipoprotein Lipase (LPL) is a key enzyme of lipoprotein metabolism. Its gene mutant influences LPL′s activity and increase triglyceride (TG) level while lowering high-density lipoprotein (HDL) level, which results in lipid metabolic disorder. These are considered to contribute to some diseases like coronary atherosclerotic heart disease, obesity-related hypertension and type2 diabetes and chronic kidney disease.But research results differ at present and a number of issues are left to be further clarified.]]> 2018/12/6 8:50:24 ZHOU Wei-ya 672true ［Abstract］　The electrocardiographic findings associated with pulmonary embolism have been widely studied in the medical literature. These abnormalities include changes in rhythm, QRS axis, and morphology, particularly in the QRS and T waves. Such findings may reflect hemodynamic changes, such as right heart strain, as well as myocardial ischemia associated with the disease. Although certain findings may correlate with the severity of pulmonary embolism, the overall utility of the electrocardiogram is limited due to the variable presence, frequency, and transient nature of most of the abnormalities associated with the disease.]]> 2018/12/6 8:50:24 TIAN Xin, YANG Peng 671true ［Abstract］　This summary summarizes the application situation and progress of the bioframenmtable anastomosis ring (BAR) used in digestion surgery both domestic and abroad, including the specific property, the survey of application all along, the application in the recostruction of alimentary tract and another field, the ways of anastomosis, the things should be taken note of when application, and the short of BAR. It might be referenced for the user of BAR.]]> 2018/12/6 8:50:24 LI Zhi-yong, HUANG Shun-rong 670true ［Abstract］　Apex of right ventricle(RVA) was the routine implanted site of the right ventricular pacing lead. Recent studies indicated that the RVA is not the ideal pacing site, so that peoples are trying to quest the more ideal right ventricular pacing site.Because the septum of the right ventricular outflow tract adjoins the His bundle, the septal pacing of the right ventricular outflow tract maybe produced preferable hemodynamics effects theoretically. However, the former results of this domain were conflicting. This article reviews the advances in the septal pacing of the right ventricular outflow tract.]]> 2018/12/6 8:50:24 HU Chang-xing 669true ［Abstract］　Objective　To introduce the guiding role of post-antibiotic effect(PAE) in reasonable clinical use of medicine，in order to promote the reasonable application of antibacterial medicine.Methods　The relevant documents were referred，the administration regimen of medicine were demostrated in combination with clinical practial appliation of medicine.Results　The existence of PAE makes the validity of medicine to prolong, PAE has guidance role in the determination of medicine dose, administration time and frequency of medicine.Conclusion　The establisment of administration regimen of medicine in combination with PAE phenomenon may raise the treatment level of antibacterial medicine and reduce the poison side effect and the treatment cost of medicine.]]> 2018/12/6 8:50:24 LIU Ji 668true ［Abstract］　Objective　To investigate the relationship between myocardial damage, renal inadequacy and the desease severity in patients with chronic obstructive sleep apnea hypopnea syndrome(OSASH).Methods　Based on the apnea-hypopnea index (AHI) and the minimum of saturation of blood oxygen (SaO₂min), 108 patients with OSAHS were divided into three groups including mild, moderate and serious groups, and 40 healthy volunteers were chosen as control group at equal pace.Then the incidences of myocardial damage and renal inadequacy were computed, and the changes of Lp(a)﹑cTnI and Cr were determined.Results　Compared with control groups, levels of Lp(a)、cTnI and Cr in OSAHS groups were significantly higher. There was significant difference(P<0.01）.Compared with different groups with OSAHS, there was aslo significant difference (P<0.01）. The incidences of myocardial damage and renal inadequacy were 52.78% and 25.93% respectively,at the same time, the incidences increased with severity of OSAHS.Conclusion　As the growing severity of OSAHS, the levels of Lp(a)﹑cTnI and Cr go up step by step as well as incidences of myocardial damage and renal inadequacy. It shows that　myocardial damage and renal inadequacy are quite common in patients with OSAHS, and Lp(a)﹑cTnI and Cr could regard as one of the indexes to appraise the severity of OSAHS.]]> 2018/12/12 16:20:04 CHEM Jin-hua 667true ［Abstract］　Objective　To explore a new operative technique to treat obsolete femoral neck fracture in young patients.Methods　Thirry-one patients with obsolete femoral neck fracture were treated by open reduction, internal fixation with 2 hollow compression screws, bone grafting of pedicled iliac bone flap with deep circumflex iliac vessels and sartorius muscle, internal fixation with kirschner pins, proper immobilization and functional rehabilitation.Results　The follow-ups of an average of 36 months showed that all the fractures healed on average 127 days after operation with satisfactory functional recovery. According to Harris scoring system, there were 20 excellent cases, 7 good cases and 4 fair cases. The patients could do routine work again. No ischemic necrosis of femoral head occurred.Conclusion　Application of open reduction, internal fixation,bone grafting of pedicled iliac bone flap with deep circumflex iliac and sartorius muscle plays an important role in promotion of fracture healing and prevention of ischemic necrosis of femoral head.]]> 2018/12/12 16:20:04 TANG Jie-fu, LI Feng, MAN Yi-wang, et al. 666true ［Abstract］　Objective　To study the effect of low dose premarin supplementary treatment in climacteric syndrome.Methods　Sixty-three patients with climacteric syndrome were randomly divided into the study group (42 patients) and the control group (21 patients). Patients of the study group were treated with premarin and medroxyprogesterone acetate. Patients of the controlled group intake Chinese patent medicines xiaoyao pill and liuweidihuang pill. The general score of climacteric symptom, the chang of E₂、FSH blood-fat in blood, and the reaction of medicine before and after treatment were observed and compared.Results　Two groups showed improvement in climacteric symptom. Compared with the control group in the study group, reduction in Kupperman score and FSH and elevation in E₂ after 6 months and one year treatment were remarkable(P<0.01). There were no significant change in blood pressure, thickness of endometrium, blood-fat,liver function and renal function among two groups (P>0.05).Conclusion　Premarin is more better than xiaoyao pill in improving climacteric symptom, such as hectic fever et al.]]> 2018/12/12 16:20:04 WEI Jing, ZENG Ding-yuan 665true ［Abstract］　Objective　To discuss the curative effect on secretory otitis media (SOM) treated with middle ear pressure transformation therapy in elderly patients.Methods　Fifty and six patients(62 ears) were divided into therapic group (28 patients, 31 ears )and control group (28 patients,31 ears ) by matched-pairs based on the age and the course of disease. The control group were treated traditional Valsalva's maneuver and the therapic group were treated with middle ear pressure transformtion therapy. The follow-up was performed three months after treatment, and the curative effects were compared.Results　The pure-tone average( PTA) of hearing thresholds at 0.5, 1, 2, and 4 kHz and air-bone gap of therapic group were significant lower than that of control group after the treatment(P<0.05).The total effective rate in therapic group was 77.42%(24/31 ears), and was 51.61%(16/31 ears) in control group, there was statistically significant difference between them (P<0.05).The rate hearing impaired beyond second grade in therapic group was 19.35%(6/31 ears)and was significantly lower than that in control group(45.16%；14/31 ears)(P<0.05).Conclusion　Treatment with the middle ear pressure transformation therapy is a safe, effective method for elderly patients with SOM.]]> 2018/12/12 16:20:04 LU Qiu-tian, ZHU Qiu-mei, LIANG Jian-ping, et al. 664true ［Abstract］　Objective　To analyzes the incidences of birth defect in nanning city from 2006 to 2007 and provide scientific foundation for making intervention measures.Methods　There were 1212 cases and 1467 cases of perinatal birth defects in the six counties and six districts of nanning city in 2006 and 2007 respectively. Their data were compared and analysed.Results　There was an increasing trend for incidence of neonatal birth defects,their incidence were 13.95‰ and 15.73‰ respectively. Among the birth defects, the first three birth defects includd cardiovascular system malformation, facial malformation (mainly harelip and cleft palate), hand and foot malformation.Conclusion　Premarital medical check-up, pre-pregnancy eugenic monitoring and instructions, early pregnancy eugenic monitoring, establishment of perinatal health care card system, and improvement of screening technology for birth defects are important measures to reduce the birth defects.]]> 2018/12/12 16:20:04 LIAO Dan-mei,YANG Mei 663true ［Abstract］　Objective　To improve the diagnosis and treatment of infective endocardits(IE) by analyzing its clinical characteristics such as clinical manifestations, basic heart disease, pathogenic micro-organisms and involved valve.Methods　The clinical data of 104 cases of IE underwent cardiac surgery from January 1999 to December 2008 were retrospectively analyzed.Results　The whole group included 13 cases over 60 years old(12.5%), 89 cases with fever(85.58%), 75 cases with anemia(72.12%), 61 cases with weight loss and weak(58.65%), 101 cases with heart murmur(97.12%), 45 cases with congenital heart disease, 33 cases with rheumatic heart disease and 7 cases with intravenous drug use. Blood culture were positive in 52 cases of 87 cases(52/87,59.77%). Streptococcus were found in 25 cases(48.08%), Staphylococcus aureus in 17 cases (32.69%) and fungal in 2 cases. Vegetations were revealed by transthoracic echocardiography(TTE) in 83 cases. Aortic valve in 36 cases(34.62%), mitral valve in 17 cases(16.35%), tricuspid in 11cases(10.58%) and joint valve in 9 cases(8.65%) were involved. There were 4 cases of early-death. 89 cases were followed-up for 1～112 months without recurrence. Postoperative cardiac function (NYHA) of 66 cases recovered to grade Ⅰand 23 cases to grade Ⅱ.Conclusion　The average age of onset of IE is increasing. Fever and heart murmur are the most common clinical manifestations. Rheumatic heart disease and congenital heart disease are the common basic heart disease, and the ratio of congenital heart disease is more than that of rheumatic heart disease. Streptococcus viridans is still the predominant organism.The aortic valve is often involved. The diagnosis mainly depends on blood culture and TTE examination. A good therapeutic effect of IE could be provided through timely surgical treatment.]]> 2018/12/12 16:20:04 GAN Chong-zhi, LIU Sheng-zhong, CONG Wei 662true ［Abstract］　Objective　To observe the effect of combined application of s-adenosylmethionine and ursodeoxycholic acid in treating patients with cholestatic virus hepatitis.Methods　One hundred and thirtytwo patients were enrolled and randomized into treated group (66 patients) and control groups (66 patients). The treated group received s-adenosylmethionine and ursodeoxycholic acid simultaneously for 4 weeks. The control group received potassium-magnesium-aspartate alone for 4 weeks. Their symptoms were observed and liver function were evaluated at 2 and 4 weeks.Results　After 4 weks of treatment,the symptom improve ment rate in treatment group were significant higher than that in control group. The treatment group had a better effect in improving of the liver function.Conclusion　 Conmbined application of s-adenosylmethionine and ursodeoxycholic acid could enhance the therapeutic effect in treating cholestatic virus hepatitis.]]> 2018/12/12 16:20:04 CHEN Shu-min, ZHANG Guo-qiang, ZHANG Yi-hui, et al. 661true ［Abstract］　Objective　To investigate the curative effects and the acting mechanism of monosialotetrahexosyl ganglioside (GM1) in the treatment of diffuse axonal injury.Methods　Eighty patients with diffuse axonal injury were randomly divided into two groups, 40 patients in the treated group were treated with GM1 injection and 40 patients in control group with citicoline injection. The treatment course were 20 days.The changes of the patients′consciousness during the treatment and the late result were observed.Results　Compared with the control group, consciousness of the patients in the treated group improved obviously after two weeks of treatment with statistically significant difference（P<0.01）.The recovery rate and the total effective rate in the treated group was 60.0% and 90.0%, and that in the control group was 37.5% and 72.5%, the comparison between the two groups showed statistically significant difference（P<0.05）.Conclusion　Monosialotetrahexosyl ganglioside possesses better awake action in the treatment of patients with diffuse axonal injury. It can reduce the duration of coma and the incidence of disability.]]> 2018/12/12 16:20:04 CHEN Jiang, WEI Feng, ZHU Shen, et al. 660true ［Abstract］　Objective　To investigate the diagnosis and treatment of Dieulafoy′s lesion in the upper gastrointestinal tract.Methods　From April 2005 to February 2008，22 hospitalized patients with Dieulafoy′s lesion were diagnosed by endoscope in our hospital.Their clinical data was analyzed retrospectively.Results　22 patients with Dieulafoy′s lesion were treated by submucosal injection of HLE (10% sodium chloride 8 ml+2% lidocaine 1 ml + 1∶10 000 epinephrine 1 ml).The effective rate of hemostasis by endoscopic submucosal injection once was 77.3%， and the total effective rate was 86.4% by injecting twice, three cases with active bleeding after injection treatment underwent operation. The mean hospitalization time was 11.7 (ranged from 3 to 24) days.Conclusion　The endoscopic submucosal injection with HLE is efficient to treat the upper gastrointestina1 massive haemorrhage caused by Dieulafoy′s lesion. And it is necessary to differentiate Dieulafoy′s lesion from upper gastrointestina1 ulcer or cancer, which can also cause profuse bleeding.]]> 2018/12/12 16:20:31 SHEN Ting，SHEN Yun-zhi. 659true ［Abstract］　Objective　To investigate the influence of rehabilitation education on recognition, language, motion, fine motor and adaptive behavior quotient in children with Down′s syndrome.Methods　The child nerve mental development scale and social living ability form were used.15 children aged 0-6 yeas with Down′s syndrome and 10 children with Down′s syndrome before 2003 from Ningxia Children′s Walfare Institute were investigated.Results　The recognition, language, motion, fine motor and adaptive behavior quotient of children with rehabilitation education after 2003 were significantly higher than that of children without rehabilitation education (P<0.05).Conclusion　After rehabilitation education, ability in every aspect of children with Down′s syndrome are significantly higher than that of children without rehabilitation education, there are an obvious correlation between the ability of recognition, language, motion, adaptive behavior quotient， fine motor and the rehabilitation education.]]> 2018/12/12 16:20:31 FAN Zhuan-ling, WANG Li-ru 658true ［Abstract］　Objective　To discuss the reason of blood platelet (PLT) examination result somewhat low in XT-1800i blood analyzer application, choose the correct method to carry on the reexamination and guarantee the PLT examination quality.Methods　 Five hundred and thirty-two specimens of PLT examination result somewhat low in XT-1800i blood analyzer application were reexamined with manual method, and simultaneously made the circumference blood smear microscopic exam to observe blood platelet shape.Results　 The results of 219 specimens were still somewhat low and there were not difference between before and after the reexamination (P> 0.05).The blood smear blood platelet showed uniform distribution and the shape was approximately normal；The results of 313 specimens reexamination showed the platelet count was normal, on 306 specimens blood smears appeared the giant blood platelet, on 7 specimens blood smears the blood platelet had the varying degree the accumulation.Conclusion　 The examination blood platelet result somewhat low specimen in blood analyzer application should be carried on the peripheral blood film with microscopy and the manual counting blood platelet.]]> 2018/12/12 16:20:31 LU Ying, LIU Yong 657true ［Abstract］　Objective　To investigate the effect of bi-level positive airway pressure noninvasive ventilation(BiPAP) on the lung function, blood gas analysis and dyspnea score of patients with chronic obstructive pulmonary disease with type Ⅱ respiratory failure. Methods　one hundred patients with COPD complicating by respiratory failure were randomly divided into control group(groupA, n=48) and treated group(groupB, n=52).Lung function tests were performed, and dyspnea score were counted before treatment and after three days of treatment; Respiratory frequency was observed and blood gas parameters including pH, PO₂, PCO₂ were recorded before treatment and after two hour, four hour, eight hour, seventy-two hour of threatment.Results　(1)compared with groupA, dyspnea score in group B decreased and lung function were improved(P<0.05). (2)The values of PH and PO₂ greatly improved and PCO₂ significantly decreased in group B after four hour of threatment（P<0.05） and after eight hour of threatment（P<0.01）, and respiratory failure were rectified after seventy-two hour of threatment（P<0.01）.Conclusion　Using BiPAP respiratory machine assistant ventilation can improve lung function, decrease dyspnea score, and rectify rapidly respiratory failure, and it were effective for patients with COPD complicating by respiratory failure.]]> 2018/12/12 16:20:31 LI Yong-pu, YANG Mei, XIA Wei, et al. 656true ［Abstract］　Objective　To investigate the correlation between sevoflurane concentration and bispectral index(BIS) during remifentanil-sevoflurane anesthesia in elderly patients.Methods　Thirty ASA class Ⅱ～Ⅲ patients aged over 60 year undergoing upper-abdominal surgery were randomized to one of two groups:the first group(60～69 year) and the second group(70～79 year). Sevoflurane was titrated to keep BIS values between 50～60 during operation.The BIS values before and during anesthesia and at extubation, sevoflurane concentration, eye opening time, extubation time, recovery time of anesthesia were recorded and compared between the two groups.Results　No statistical differences were found in eye opening time, extubation time and recovery time of anesthesia between two groups.There was a positive correlation between BIS values and the age.A positive correlation exists between the values of BIS and sevoflurane concentration during surgery.Conclusion　A positive correlation exists among BIS, age and sevoflurane concentration in elderly patients.To choose safe sevoflurane concentration according to the age to keep BIS values between 50～60 in elderly patients is necessary.]]> 2018/12/13 9:29:22 SHI Bin 655true ［Abstract］　Objective　To study the influence of antioxidant Probucol on urine β₂ microglobulin (β₂-MG) and micro albumin (Alb) in patients with hypertension and diabetes.Methods　 Levels of blood and urine β₂-MG and urine micro Alb were measured on normal control (n=60) and patients with hypertension (n=110), diabetes (non insulin treatment) (n=92), and both hypertension and diabetes (n=88) before treatment. The combination of antihypertensive and hypoglycemic and the administration of antioxidant Probucol were stopped after 12 weeks, and the protein levels were measured for comparison.Results　Levels of blood and urine β₂-MG and urine micro Alb were generally higher in patients than those in control. With the treatment of combination of antihypertensive and hypoglycemic plus Probucol, the protein levels were decreased significantly in patients with both hypertension and diabetes (P< 0.05).Conclusion　Either hypertension or diabetes can increase the protein level of blood and urine β₂-MG and urine micro Alb. Furthermore, they have additive effect on patients. Antioxidant Probucol is able to lower the level of micro Alb in urine, therefore protect function of kidney.]]> 2018/12/13 9:29:22 LIU Wei-hua, LIANG Ling, PANG Zheng-yao 654true ［Abstract］　Objective　To evaluate the curative effects and the security of insulin glargine combined with repaglinide in the treatment of type 2 diabetes mellitus.Methods　Fifty-eight patients with type 2 diabetes mellitus from the community where shengjian 83 Hospital is located from June 2007 to December 2007 were treated by insulin glargine combined with repaglinide.The fasting blood glucose, 2 hours postpradial blood glucose, glycosylated hemoglobin, the body weight and the body weight index were measured, and the incidence of the hypoglycemia was observed.Results　All the 58 patients being selected completed the treatment and the observation.After 24 weeks of the treatment, the mean values of fasting blood glucose, 2 hours postpradial blood glucose, glycosylated hemoglobin decreased by 2.17mmol/L, 3.26mmol/L and 1.45%respectively, the difference were statistically significant(P<0.05).The body weight and the body weight index slightly increased, but the difference were no statistionly significant. The incidence of hypoglycemia was lower. Conclusion　The effects of blood glucose control of insulin glargine combined with repaglinide in the treatment of type 2 diabetes mellitus were good, the incidence of hypoglycemia is low and the compliance is good.]]> 2018/12/13 9:29:22 SHANGGUAN Shi-guo 653true ［Abstract］　Objective　To investigate the effect of noninvasive intermittent positive pressure ventilation on the patients with severe pneumonia after renal transplantation.Methods　The parameters of 22 patients with severe pneumonia after renal transplantation including the ratio of partial pressure of oxygen in artery to fraction of inspiratory oxygen(PaO₂/FiO₂), heart rate (HR), mean arterial pressure(MAP), respiratory rate(RR), and partial pressure of carbon dioxide(PaCO₂) during pre- and post-NIPPV, the prognosis, and complications were analyzed retrospectively. Results　NIPPV was implemented in 22 patients. Nineteen patients were ventilated successfully primarily. Twelve patients were halfway switched to endotracheal intubation and invasive ventilation. PaO₂/FiO₂ of the patients achieving NIPPV was increased significantly after two hours of NIPPV［(189.7±64.5)mmHg vs (148.6±45.7)mmHg, P<0.05］ and was increased gradually by the time. HR, MAP, RR, and PaCO₂ were ameliorated. The mortality of the patients with NIPPV was 57.9%. The mortality of the patients with invasive ventilation was 93.3%. The total mortality of all patients was 68.2%. Among the patients of NIPPV, there were 3 gastric insufflations and 1 skin ulcer.Conclusion　NIPPV could improved the poor oxygenation of the patients with severe pneumonia after renal transplantation in the early stage with few complications and reduce the mortality.]]> 2018/12/13 9:29:22 DING Ming-dong， ZHOU Da-ming, ZHANG De-geng, et al. 652true ［Abstract］　Objective　To study the efficacies of sequential non-invasive following short-term invasive mechanical ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods　Thirty-six AECOPD patients intubated were randomly divided into two groups, each group having 18 cases.The study group was treated with sequential non-invasive following short-term invasive mechanical ventilation when pulmonary infection had been controlled（PIC window）, and the control group was treated with invasive mechanical ventilation continually.And the changes of the clinical characteristics, the incidence of ventilators-associated pneumonia(VAP) and deaths, the duration of mechanical ventilation, days in hospital were compared.Results　Compared with the control group, the study group had lower rate of VAP (1/18, 8/18, P<0.05), shorter duration of invasive mechanical ventilation［(5.56±0.37)d，(12.50±1.18)d，P<0.05］，shorter duration of total mechanical ventilation ［(8.50±0.41)d，(12.50±1.18)d，P<0.05］，and fewer days in hospital［(11.41±0.84)d，(17.72±0.98)d，P<0.05］. There was no significant difference in the clinical characteristics and mortality in hospital between these two groups (P>0.05). Conclusion　In paitents with AECOPD requiring intubation, sequential non-invasive following short-term invasive mechanical ventilation can significantly improve the curative effect, at the point of PIC window.]]> 2018/12/13 9:29:22 LUN Yan-hong, YAN Jian-wei, LIN Run-pei 651true ［Abstract］　Objective　To evaluate the therapeutic effects of fluimucil on children with acute bronchitis.Methods　Two hundred cases with acute bronchitis were randomly divided into treatment group (100 cases) and control group (100 cases).Both groups adopted anti-infection, fluimucil was given in treatment group and control group used bromhexin.The treatment course was designed to be 5 days.And then the symptoms and duration were observed and compared.Results　After 3 day course of treatment, the effects on cough and sputum were much better in treatment group than in control group(P<0.01).Compared with control group, the cases in treatment group were more significant in disappearence of cough and sputum(P<0.01).The total improvement rate of clinical symptoms was 99% in the treatment group and 85% in the control group with a statistic significance（P<0.01).Conclusion　Fluimucil in treatment of acute bronchitis is effective and safe with a good compliance.]]> 2018/12/13 9:29:22 WU Qi-fu 650true ［Abstract］　Objective　To observe the therapeutic effects of low-molecular-weight heparin (LMWH) in treatment of cerebral infarction (CI) in different time windows.Methods　According to the admitted date, 75 selected patients with CI were randomly divided into three groups: A group (<24h), B group (24～48h) and C group (49h～7d). All patients in three groups were treated with abdominal subcutaneous injection of LMWH 5000 IU, twice daily for 7days. The neurologic impairment score and effectiveness of three study groups were evaluated before treatment and the 8th day after the treatment.Results　 The neurologic impairment score of three groups were significantly decreased after the treatment of LMWH (P<0.05 orP<0.01). Significant difference were found in the neurologic impairment score differences before and after treatment in three groups(P<0.05), and the differences of A group was bigger than those of C group(P<0.05). In three group, significant difference were also found in the total effective rate(P<0.05), and the the total effective rate of A group was higher than that of C group(P<0.05).Conclusion　LMWH could effectively improve neurologic impairment and prognosis of patients with CI in different time windows especially in 24 hours.]]> 2018/12/13 9:29:22 QIN Cong-jun, JIANG Shun-jian, LIAO Jun 649true ［Abstract］　Objective　To understand the situation of disease of feminine urinary by means of cluster random sampling with Questionnaire incontinence in Anjuoen, Comoros, Africa.Methods　Two thousand six hundred and ninety-six women who live in Mouzamoudou and Henbo in this area were investigated.Results　It showed that general rate of urinary incontinence was 27.8%. Among them, 51.1% were older than 50 who suffered from stress urinary incontinence, urge urinary incontinence and mixed urinary incontinence with the disease rate of 13.7%, 3.6% and 10.5% respectively, occupied 49%, 13% and 38%. Mild urinary incontinence was the major. In the survey, 80% of the respondents did not know how to go to a doctor, 20% did not know where to get a medical advice.Conclusion　Urinary incontinence is a common disease happened in women, with a higher disease rate in old female, but a very lower rate for medical treating.]]> 2018/12/13 9:29:22 WANG Ting 648true ［Abstract］　Objective　To investigate the effect of L-carnitine on quality of life and anemia in maintenance hemodialysis(MHD) patients. Methods　 Thirty MHD patients were randomly divided into treatment group(n=15) and control group(n=15). All of the patients were received 3000IU of rhEPO subcutaneous injection, 2 to 3 times a week after hemodialysis.In treatment group, 1.0g of L-carnitine was infused to the patients at the end of each dialysis treatment for 12 weeks.SF36(Short Form with 36 questions)score about LQ were recorded and analyzed. Hb, Hct and Alb were measured before and after treatment.Results　In treatment group each item was significantly increased after treatment (P<0.05) while no significant changes was found in control group.Conclusion　Using L-carnitine may improve quality of life and anemia in MHD patients.]]> 2018/12/13 0:00:00 XU Xiao-lin 647true ［Abstract］　Objective　To compare the measured results from 4 hemotology analyzers using nonlinear procedure. Methods　Daily 5 blood samples with high, normal and low measured values from patients were collected and analyzed respectively using 4 hemotology analyzers, Bayer120, CD3500, BC5500 and BC3000. The measured results of WBC, RBC, HGB and PLT from CD3500, BC5500 and BC3000 were respectively related to Bayer120 through 11 regression models (including linear model) from SPSS curve estimation program.Results　The coefficient of determination (R²) of all best regression models found out was more than 0.981, and then method comparison and bias estimation between different hemotology analyzers could be made with more exact bias estimation and wider comparative range than only using linear model.Conclusion　Nonlinear comparison is suitable for method comparison and bias estimation for clinic laboratory.]]> 2018/12/13 9:29:50 QIN Gui-fang, TAN Chun-yan, MO Zhi-jiang, et al. 646true ［Abstract］　Objective　To comparatively analyze the clinical effects of hemiarthroplasty and proximal femoral nail internal fixation for treatment of unstable intertrochanteric fractures in aged patients and evaluate the merits and defects of the two methods.Methods　From May 2002 to June 2008, 78 elderly patients with unstable intertrochanteric fractures were choosed at random. 42 cases were treated with hemiarthroplasty and 36 cases were treated with proximal femoral nail internal fixation. The clinical data of the two groups such as the preoperative coexisting diseases, duration of operation, intraoperative blood loss, units of blood transfused, time of weight-bearing, duration of hospitalization, postoperative complications and the last followed-up Harris scores of affected hip joint were collected for statistical analysis. Results　The average followed-up time was 26.5 months ranged from 6 months to 48 months. In comparison of the preoperative coexisting diseases, fracture classification and condition of osteoporosis (Singh index), there was no significant difference between the two groups (P>0.05). While in comparison of the duration of operation, duration of hospitalization, blood loss and units of blood transfused, the differences were significant (P<0.05). Weight-bearing time of two groups was similar. The average postoperative Harris scores of hemiarthroplasty group was 83±12.8, the difference was significant in contrast of PFN group. Conclusion　Proximal femoral nail and hemiarthroplasty are effective and satisfactory methods to treat unstable intertrochanteric fracture in aged patients and have the same functional recovery outcomes, but proximal femoral nail internal fixation has the advantages of shorter operation and hospitalization time and less blood loss.]]> 2018/12/13 9:29:50 CAO Zhi-pin 645true ［Abstract］　Objective　To investigate the prevalence of diabetes and impaired glucose regulation among permanent inhabitants in Sanming, Fujian province. Methods　551 residents (over 16 years old) were selected from the urban area of Sanming by multistage cluster random sampling between October and December in 2007. All the participants underwent anthropometric measurements, blood biochemical analyses and a 75 g OGTT. Results　The crude prevalence of diabetes and IGR was 10.5% and 13.6% (1.5% for I-IFG, 12.1% for IGT), respectively. Based on the 2000 census of China, the age-standardized and sex-standardized prevalence of diabetes and IGR was 7.4% and 11.3% (0.8% for I-IFG, 10.5% for IGT), with a ratio of IGR to DM 1.53. 55.17% of diabetes were undiagnosed. The age-standardized and sex-standardized prevalence of hypertension, obesity and overweight were 27.8%、8.7% and 29.5%. Conclusion　The prevalence rates for diabetes and IGR have increased dramatically over the last decades in Sanming, still a large proportion of cases are undiagnosed. With the aggravation of aging and urbanization, the prevalence of DM will increase faster than ever before.]]> 2018/12/13 9:29:50 ZOU Xin, ZHANG Ya-dong, ZHU Feng-yuan, et al. 644true ［Abstract］　Objective　 To discuss the relationship between HBV genotypes and the clinical outcome of hepatitis B.Methods　HBV genotypes were detected by PCR-DNA hybridization-plate-ELISA in 168 cases of chronic HBV infection, to understand HBV genotype distribution of different clinical types, clarify the rclationship between HBeAg and HBV genotype the relationship between HBV genotype and Clinical outcome of the liver; the relationship between HBV genotype and age-sex.Results　In 168 cases of chronic HBV infection, there were 78 cases of genotype B (46.43%), 90 cases of C genotype (53.57%). In patients with liver cirrhosis and liver cancer, C genotype (73.17%) was significantly more than genotype B (26.83%), with statistically significantly difference (P<0.05).In 90 cases of C genotype, 62 patients were HBeAg positive and 28 cases HBeAg negative, and there was a significant difference (P<0.05). In the high age group C genotype was dominant.Conclusion　HBV genotype and clinical outcome of hepatitis B have the close relation, C genotype is one of primary causes of sustained HBeAg positive, liver, cirrhosis.and liver cancer.]]> 2018/12/13 9:29:50 SUN He-cai, LI Shu-li 643true ［Abstract］　Objective　 To investigate the influence of shuxuetong injection to the carotid atherosclerosis.Methods　 One hundred and sixty-six patients with carotid atherosclerosis who were diagnosed by color doppler ultrasonography were divided into two groups, with 84 cases in treatment group(group A), and 82 cases in control group(group B). Group A was treated with shuxuetong injection, and the group B with simvastatin dispersible tablet combined with mailuoning injection, simvastatin dispersible tablet was taken before resting qd, 20 days were a treatment course for two group.Results　Intima-media thickness, long axis, total plaque area, average number in group A treated by shuxuetong injection were obviously improved and the effect was better than group B that treated by simvastatin dispersible tablet combined with mailuoning injection.Conclusion　Shuxuetong injection has the good anti-atherosclerosis function.]]> 2018/12/13 9:29:50 WEN De-shu, WU Zhi-wu, MA Li-qin 642true ［Abstract］　Objective　To evaluate the effects of health promotion intervention on hypertension knowledge, attitude, behavior and the change of blood pressure among hypertension patients on the community, in order to provide effective countermeasure of prevention and cure for the administrative departments.Methods　 230 hypertension patients were randomly selected from intervention group and control group respectively, and questionnaire survey of their knowledge, attitude, behavior were performed.Results　The intervention group knew more about hypertension knowledge than control group, including measuring blood pressure once a month, having medicine according to the doctor′s advice, the intervention group did better than the control group. Mean of systolic and diastolic blood pressure were significantly decreased (2.1/3.8 mmHg, respectively) in the patients with hypertension after intervention.Conclusion　It is effective to hypertension patients through setting up a health life style to control the blood pressure and prevent complication of the disease by health promotion intervention in rural area community.]]> 2018/12/13 9:29:50 LI Ren-fu, SU Fa-wo, LAI Wei-jian 641true ［Abstract］　Objective　To evaluate the variety characteristics of ECG and the misdiagnosis reason of the first diagnosis of NSTEMI.Methods　The contrastive analysis of ECG data of 45 misdiagnosed patients with NSTEMI and 50 patients with CHD at my hospital in 10 years, and the informations of two sets of first misdiagnosed patients were analysed.Results　They all had ST and T ischemic change of ECG at first diagnosis. There were no difference between two groups in ST-T ischemic change, merely ST descended, lowering of T-wave or inversion, normal ST-T and arrhythmic probability(P>0.05); There were more ST descended≤0.1mv in contros group, more ST descended≥0.2mv in NSTEMI group(P<0.05).The ratio of misdiagnosed in NSTEMI group was obviously higher than that in control group（P<0.01).The misdiagnosis rate of doctors of cardio-vessel medicine was lower than that of doctors of other medicine in NSTEMI group（P<0.05）, but in control group misdiagnosis rate was quiet（P>0.05).Conclusion　The ECG of NSTEMI has ST-T dynamicly changed, but appeared often not typically, the clinical misdiagnosis rate is higher, we have to pay more attention on it.]]> 2018/12/13 9:29:50 LI Yang, LIN Yu 640true ［Abstract］　Objective　To observe the relationship between ischemic stroke and carotid atherosclerosis.Methods　Fifty-nine hospitalized patients with cerebral infarction (CI group) and 56 hospitalized aged patients (control group) at the same period without cerebral infarction were assessed by color doppler ultrasonography, the characteristics of carotid atherosclerosis between two groups was compared, respectively.Results　The incidence of carotid atherosclerosis lesions in CI group was significantly higher than that in control group at all parts. In two groups were highest incidence of carotid atherosclerosis lesions at BIF(71.19% vs 51.79%). The ratio of mixed plaque and unstable plaque were significantly higher in CI group than that in control group.Conclusion　Carotid atherosclerosis especially unstable plaque has intensive relationship with ischemic stroke, it can be used as one of the important indexes of predicting stroke.]]> 2018/12/13 9:29:50 ZHOU Te-fei, ZHANG Kui-hua, YING Wei-qun, et al. 639true ［Abstract］　Objective　To observe the effect of the penehyclidine hydrochloride and atropine on the treatment of acute organophosphorus pesticides poisoning. Methods　Forty and seven cases with oral organophosphorus pesticide poisoning were randomly divided into the control group and the therapeutic group. Patients in the control group were treated with atropine and pralidoxime chloride, and patients in the therapeutic group were treated with penehyclidine hydrochloride and pralidoxime chloride. Results　The course of disease, hospitalization expense, incidence of overdose， incidence of side reactions in the therapeutic group differed markedly from the control group(P<0.01). The times of administrating drugs in the penehyclidine hydrochloride group were less than that in the atropine group(P<0.001). Conclusion　The efficacy of penehyclidine hydrochloride in treating organophosphorus pesticide poisoning was significantly better than that of atropine. So penehyclidine hydrochloride is worth generalizing and applying clinically.]]> 2018/12/13 9:29:50 YU Ning, TANG Yu-tao 638true ［Abstract］　Objective　To discuss some skills concerning the operation for cleft palate and clinical applications of these skills.Methods　Retrospecting 168 cases of surgical operations for cleft palate repair, some surgical skills for cleft palate, including selection of operative methods, usage of electrotome, sequence of incisions, stripping and slacking of mucoperiosteal flap, usage of noninvasive absorbable surgical sutures, dealing of alveolar ridge and anterior palate, closure of mucous membrane in the nasal cavity, dealing of uvula, anatomy and function reconstruction of levator veli palatine, and filling up of the flabby wounds, were evaluated. A clinical analysis was made for the outcome.Results　All of 168 cases but four have got excellent healing, with good shape of uvula and satisfactory activity of soft palate. Perforation occurred in alveolar cleft in three cases and one in soft palate.Conclusion　The application of certain skills for cleft palate surgery is helpful to shorten operation time, decrease bleeding during the operation, reduce suture tension, alleviate tissue edema, avoid perforation and rupture, figure uvula, restore anatomic structure and physiologic function of palate, promote wound healing，and improve the succession rate of operation.]]> 2018/12/13 9:29:50 YANG Shou-kang, SUN Guo-liang, ZHANG Hao 637true ［Abstract］　Objective　To analyse the sensitivity of isolated gramnegative bacterium to cephamycine antimicrobial in recent four years of our hospital.Methods　Identification of bacteria，sensitivity analyses and ESBLs were detected by professional numbers in the Lab. of the hospital.Results　Among six kinds 2238 clinical identified gramnegative strains, 876 were cefoxitin resistance(39.14%). Of the 2238 strains, M.Stenotrophomonas, P.aeruginnosa and A.baumanii/Calcoaceticus/ Lwoffi were more resistance to cefoxitin and were 94.03%, 72.56% and 67.59% respectively. All proteus mirabilis were sensitive to cefoxitin(100%). Most escherchia coli and K.pneumoniae were still more sensitive to cefoxitin and their resistant rate were 29.73% and 27.61% respectively.Conclusion　The usage of antimicrobial must be administrated strictly, especially the using of beta-lactamase antimicrobial. The work of AmpC enzyme should be developed in the hospital, so as to raise the accuracy of reporet on bacterial resistance and make reasonable choice in antimicrobial administration clinically.]]> 2018/12/13 9:29:50 LI Guo-qin 636true ［Abstract］　Objective　To analyse the colore doppler supersonic diagnosis of seventy patients with carotid atherosclerosis disease and to explore the pathological changes regularity.Methods　The patients were divided into diabetes mellitus group (n=11), hypertension group(n=24), cerebral infarction group (n=6), cervical vertigo or vertebrobasilar insufficiency group(VBI)(n=18), coronary heart disease group (n=5), other group(n=6). The lessions were lipid storage, the soft, hard and compound plaques.Results　There are 32 case of patients with lesions of carotid atherosclerosis plaque and lipid deposition, 20 case of male（62.5%）, 12case of female（37.5%）. The average age of diabetes mellitus group was 67.7years. The average ageof hypertension group was 64.25years. The average age of cerebral infarction group was 68.2years. The average age of cervical vertigo or VBI group was 62.3years. The average age of coronary heart disease group was 68.2years. The prevalence of carotid artery plaque in hypertension and cerebral infarction group were 37.5% and 66.6% respectively. The prevalence of carotid artery plaque in cervical vertigo or VBI and coronary heart disease group were 22.2% and 80% respectively.There was no significant difference between the different age groups.Conclusion　The diabetic patients with carotid atherosclerosis have the highest rates, followed by coronary heart disease, cerebral infarction, hypertension and vertebrobasilar insufficiency. Low-flow shear stress and high tretch stress is of atherosclerosis major risk.Vascular endothelial dysfunction is also an important factor.]]> 2018/12/13 9:29:50 LONG Qi, CHEN Wei-dong, XU Gui-ying, et al. 635true ［Abstract］　Objective　To evaluate the efficacy and the cost-effectiveness of different rabeprazole tablet products in triple therapies of helicobacter pylori eradication.Methods　Ninety-eight patients with peptic ulcer under gastroscopy and positive helicobacter pylori urease tests and pathological positive hp were selected, on the first week group A was administrated with ruibote tablets (domestic rabeprazole entericcoated tablets) 10mg po, bid, ac, and amoxicillin 1g and clarithromycin dispersible tablets 0.5g, po. ac. 1h bid, for 7 days, and then ruibote 10mg po, bid, ac, for 3 weeks. on the first week group B was administrated with pariet (imported rabeprazole entericcoated tablets) 10mg po, bid, ac, and amoxicillin 1g and clarithromycin dispersible tablets 0.5g, po, ac, 1h bid, for 7 days, and pariet 10mg po, bid, ac, for 3 weeks. The ulcer healing effect of group A and B was observed in the 4 weeks and evaluated by the cost-effectiveness method of pharmaceutical economics.Results　 There were significant differences between pre and post ulcer healing effect in group A and B(P<0.05) and ruibote had better cost-effectiveness results.Conclusion　ruibote is safer, more effective and more economical in treatment of helicobacter pylori positive peptic ulcer than pariet, and is more suitable for our national conditions for clinical extension]]> 2018/12/13 9:29:50 FU Cui-li, CAI Lian-ying, LI Yi 634true ［Abstract］　Objective　To compare the clinical diagnosis value between an enzyme-linked immunosorbent assay(ELISA) for embryonic zeta-globin chains and polymerase chain reaction(PCR) method as a routine screening test for(--^SEA)α-thalassemia in clinical laboratory. Methods　Two hundred and ten blood samples（115 cases normal; 95 cases MCV<80 fl、MCH<27 pg, Hb 25～128 g/L）from consecutive outpatient and obstetrical inpatients in The People′s Hospital of Guangxi Zhuang Autonomous Region with a request for hemoglobin (Hb) analysis were screened simultaneously for α-thalassemia determinants by ELISA and PCR respectively.Results　There were very significant higher sensitivity, specificity, accuracy and negative predictive values as well as positive predictive values of ELISA method(96.2%, 98.3%, 97.6%, 98.3% and 96.2%, respectively) like PCR (100%, 100%, 100%, 100% and 100%, respectively) for screening for --^SEA carrier(all P>0.01).The ELISA method was capable of detecting effectively only the cases with -α/αα. But it had a low positive rate in neonatal cord blood (only 65%).Conclusion　The ELISA method is a highly sensitive and specific and reliable test for -α/αα and is more effective, The ELISA method is simple to perform, rapid, and applicable to large-scale or population-based screening programs and to a routine diagnostic laboratory.]]> 2018/10/22 8:14:38 ZHANG Jin-li, HUANG Jun, LIU Xiao-chun, et al. 633true ［Abstract］　Objective　To analyse the causes, and clinical features of young patients with cerebral infarction.Methods　Retrospective study of clinical data of 103 youth patients with cerebral infarction was carried out.Results　Ninety-four patients had definite pathogeny(91.26%), Nine patients had unclear pathogeny(8.74%). The most common cause was atherosclerosis （45 cases）, accounted for 43.69%, followed by 18 cases of cerebral arteritis accounted for 17.48%.The clinical features were:44 cases occured between the ages of 30 and 39 years, accounted for 42.72%;50 cases occured between the ages of 40 and 45 years, accounted for 48.54%; 68 cases were male accounted for 66.02%, the unilateral limb asthenia was the common as first symptom; consciousness was rare. Infarction sites: mainly located in basal ganglia (37 cases), accounted for 35.92%, followed by 17 cases of cerebral lobes accounted for 16.50%;the prognosis was better, with low fatality rate.Conclusion　The causes are complicated in youth patients with cerebral infarction, the mostly common pathogeny is atherosclerosis, lesions are mainly located in anterior circulation, the prognosis is well.]]> 2018/10/22 8:14:38 BAI Hua, ZHANG Qian 632true ［Abstract］　Objective　To research the effects of aspirin plus leibeirazole (LBLZ) in the treatment of acute cerebral infarction (ACI).Methods　Thirty-one ACI patients were divided into two groups. Treatment group received aspirin and LBLZ, contral group only received aspirin treatment. NIHSS, Fugl-Meyer and SF before and affer treatment in groups of patients were observed and analyzed.Results　The treatment group is lower than the control group in NIHSS and is higher in Fugl-Meyer and SF. The two groups had significant difference (P<0.05).Conclusion　LBLZ can improve neurologic function, and play a posttive role in the treatment of ACI.]]> 2018/10/22 8:14:38 YANG Yong 631true ［Abstract］　Objective　To investigate the clinical value of tumor marker alphafetoprotein (AFP), γ-glutamyle transpeptidase(GGT) and serum ferritin(SF) in the diagnosis of PHC. Methods　AFP, GGT, SF in the serum were studied in 61 patients with PHC, 64 with hepatitis or LC, and 55 healthy individuals.Results　The positive detection rate of AFP and SF in PHC were significantly higher than that in the hepatitis or LC（P<0.05）, but there was no statistically significant difference between the two groups in GGT（P>0.05）.Combined assay of AFP, GGT and SF will increase the detecting rate up to 96.7%, higher than any single marker examination respectively （P<0.05）. Conclusion　The combining AFP, GGT and SF examination are superior to any single marker examination and can greatly increase the detecting rate of PHC.]]> 2018/10/22 8:14:38 XIONG Biao, CHEN Zhi-ping 630true ［Abstract］　Objective　To understand the effect of ropivacine in high epidural anesthesia on respiratory and circulatory system and its clinical effects.Methods　Forty ASA Ⅰ - Ⅱ level patients underwent breast surgery were randomly divided into two groups, each group 20 cases. The patient were performed conventional puncture in the T_3-4 epidural space and placed the tube to head end. A group received 0.25% ropivacaine epidural anesthesia, B group received 0.25% bupivacaine epidural anesthesia. Respectively, before anesthesia (T₀), at 10 min (T₁), 30 min (T₂), 60 min (T₃) after anesthesia and at end surgery (T₄), the heart rate, blood pressure, tidal volume, respiratory frequency, minute ventilation, block time and the analgesic effect and so on were measured.Results　The narcotic effects of 40 patients were good.In the two groups the heart rate, blood pressure at T₂, T₃ decreased than before anesthesia (P <0.05). The comparison of respiratory index before and after surgrey was no statistical significance. In inter-group comparison, decrese of HR at T₂, T₃ in group A was less than that in B group, the changes of respiratory rate in A group was smaller than that in B group (P <0.05).Conclusion　Ropivacaine block can significantly shorten the onset time of sensory nerve block, improve the analgesic effect, and have smaller effect on the circulatory and respiratory function, it is safe and effective for high epidural anesthesia.]]> 2018/10/22 8:14:38 SHI Liang, WU Di, XIE Wen-pin 629true ［Abstract］　Objective　To observe the effect of the double-side design precision attachment denture in restoration of double extension defect. Methods　Fifty-eight patients who dissatisfied with removable partial denture (RPD) were restored with precision attachment.Results　The patients were fallowed up for 6 months to 4 yeas, the precision attachment was superior to RPD in retention and stability, masticatory efficiency, comfortable feeling and esthetics effect. Conclusion　For double-side extension defect denture with dissatisfied RPD, the precision attachment is a practical method.]]> 2018/10/22 8:14:38 XU Cheng-wen 628true ［Abstract］　Objective　To observe the clinical efficacy of ascites due to cirrhosis treated with chinese medical herb combined with the common western medicine diuretics, and compare the influence of chinese medical herb diuretics and western medicine diuretics on electrolyte balance in the treatment process of ascites due to cirrhosis.Methods　Two hundred patients with ascites due to cirrhosis were divided into the treatment group and control group randomly. According to the whole concept of chinese medicine theory, the patients of treatment group were diagnosed and treated basing on an overall analysis of the illness and the patients condition.The treatment group adopted the methods of soothing the liver, invigorating the spleen, warming the kidney, spreading lung on the basis of taking the common western medicine diuretics (spironolactone tablets and furosemide tablets, etc).Each patient had their own prescription, added one dose of chinese medical decoction or reserving clysis every day. the patients of control group adopted diuretics alone(with the same method as the treatment group). The two grups had the same other treatment. The efficacy observation time was two weeks.The main observation indexes included the changes of clinical symptom, physical sign, type-B ultrasonic examination and blood potassium comentration.Results　The total effective rate of the treatment group and control group were 85.0% and 72.0% respectively;the two groups had significant difference (χ²=5.01，P<0.05）);the significant rate were respectively 45.0%、25.0%，the two groups had significant difference（χ²=8.33，P<0.01）.In the course of treatment, the number of patients whose original normal blood serum potassium concentration changing to hypokalemia or whose original hypokalemia becoming more serious in the treatment group and the control group were 20, 35 resptclively, the two groups had significant difference (χ²=4.59，P<0.05）).Conclusion　Compared with western medicine diuretic, integrated traditional chinese and western medicine in the treatment of ascites due to cirrhosis has high clinical efficacy, the two method has significant difference in the total effective rate and significant rate;integrated traditional chinese and western medicine curing ascites due to cirrhosis has priority in maintaining electrolyte (blood potassium) balance. The mechanism of action and long-term clinical efficacy of traditional chinese herb in diureses and maintaining electrolyte (blood potassium)balance should be further observed and researched.]]> 2018/10/22 8:15:02 CHEN Sheng-peng, ZHU Ji-min, HUO Jiang-tao 627true ［Abstract］　Objective　To analyse the changes of electrolytes in neonates with asphyxia within 72 hours after birth retrospectively.Methods　Twenty-three neonates suffered from asphyxia were chosen as the asphyxia group and 17 neonates without asphyxia were chosen as the non-asphyxia group. Venous blood samples of 2 ml were drawn at 0～24 hours, 25～48 hours and 49～72 hours respectively. Then the data of the two groups were compared on the changes of electrolytes (such as plasma sodium, potassium, chlorine, calcium and magnesium) and the incidence of hyponatremia, hypokalemia, hypocalcaemia and hopomagenesemia.Results　The rates of hyponatremia and hypocalcaemia in asphyxia group were much higher than those in non-asphyxia group in all of the 3 periods. There were significant difference between the two groups(P<0.05).The level of plasma magnesium was much higher in asphyxia group in periods of 25～48 hours and 49～72 hours. There were significant differences in 25～48 hours and 49～72 hours(P<0.05) while no significant difference in 0～24 hours(P>0.05). Only in the period of 49～72 hours, the level of plasma potassium in asphyxia group was significantly lower than that in non-asphyxia group (P<0.05). However, there were no differences in plasma chlorine and phosphonium between the two groups(P>0.05).Conclusion　Electrolytes disorders can appear not only in 24 hours but also in different periods after asphyxia, therefore, it is necessary to maintain homeostasisb by taking corresponding measures according to the changes of blood gas and the changes of electrolytes.]]> 2018/10/22 8:15:02 XIE Yan-qi, ZHAO Ruo-wen 626true ［Abstract］　Objective　To observe the effects of treatments with radix astragali and antibiotics on bowel function in rats after shigella flexneri infection. Methods　Forty male Wistar rats were divided into normal control, model, antibiotics-treatment, radix astragali and antibiotics combination treatment groups. Each group was given the corresponding treatment after sucescful model. At 15～20 days after treatment, the perceptual threshold was detected. Results　The perceptual threshold greatly decreased in the model group and antibiotics treatment groups (P<0.05), while that of the combination treatment group had no difference from the normal control. Conclusion　Shigella flexneri infection can lead to bowel sensory motor disorder that remains for a period of time after inflammation diminishes. Treatment with antibiotics single cannot normalize the functional disturbance, but a combination treatment with radix astragali and antibiotics can.]]> 2018/10/22 8:15:02 XIE Zi-ren 625true ［Abstract］　Objective　To study the clinical effect of neoadjuvant chemotherapy(TEC) on advanced breast cancer. Methods　The TEC neoadjuvant chemotherapy ［CTX 500 mg/m²(1 st day), docetaxel 75 mg/m²(1 st day), and epirubicin 60 mg/ m² (1 st day) every 3 weeks ］ was carried out in 28 advanced breast cancer patients for 2 cycles before operation, and compared with 24 concurrent operable patients with advanced cancer, who did not receive any preoperative therapy. Results　The overall response rate was 82.14%(23/28) in TEC neoadjuvant chemotherapy group. The stages of 18 of the 24 patients(64.28%) was downgraded. The disease free survival time of the patients was 49.6 months which was obviously longer than that of patients without neoadjuvant chemotherapy (40.2 months, P<0.05). The 50-month disease-free survival rate of the patients with neoadjuvant chemotherapy was 32.41% which was a little higher than that(29.16%) of the patients without the chemotherapy, but the two groups had no significant difference. Conclusion　Neoadjuvant chemotherapy can downgrade the stage of patients with advanced breast cancer, provide an optimal time for operation, obviously prolong the disease-free survival time of the patients, and reduce or delay recurrence or metastasis.]]> 2018/10/22 8:15:02 SUN Cheng-hou, ZHOU Qian, WANG Qing 624true ［Abstract］　Objective　To observe the effect of early rehabilitation intervention on the recovery of motor function and activites of daily living(ADL) in acute stroke patients in the stroke unit.Methods　A total of 103 stroke patients were recruited and randomly divided into rehabilitation group (52 patients) and control group (51 patients). The patients in the rehabilitation group were treated with medications therapy, physical therapy(PT) and occupational therapy(OT). The patients in the control group were treated with medications therapy alone. All the patients were assessed with Fugl-Meyer（FAM）and modified Barthel index (MBI) at admission at end of one month therapy, and two months therapy.Results　There was no significant difference between rehabilitation group and control group with regard to FAM and MBI at admission. The scores of FAM and MBI were increased after therapy. The difference between the two groups after therapy was significant (P<0.01), and the complications in rehabilitation group were decreased significantly (P<0.01).Conclusion　Early rehabilitation intervention could improve the motor function and ADL of the stroke patients, and reduce the complication.]]> 2018/10/22 8:15:02 MA Li-qin, WEN De-shu, QIN Pei-hong 623true ［Abstract］　Objective　To explore the effect of closed reduction in combination with percutaneous vertebroplasty (PVP) for the treatment of osteoporosis vertebral compression fractures.Methods　Thirty-eight patients with osteoporosis vertebral compression fractures were treated with closed reduction under c-arm x-ray monitoring by extending on the operating table, and then PVP was performed on the fractured vertebra. The results of pre-operation, 3 days after and 6 monthes after the operation were quantitatively evaluated according to the concept of estimated vertebral height loss and Cobb angle of the vertebral compression fracture.Results　Operations on the 44 vertebraes of 38 cases were successful.Bone cement leakage happened in two cases including anterial and lateral leakge without posterial leakage. Pain scores, vertebral heights and Cobb angle improved significantly (P<0.05) after the surgery.Conclusion　The modified closed reduction in combination with PVP was effective in the treatment of osteoporosis vertebral compression fractures.]]> 2018/10/22 8:15:02 LU Mao-de, QIU Ji-ren, LI Yu-xiang, et al. 622true ［Abstract］　Objective　To explore the clinical effect and indication of posterior internal fixation through lateral pedicle by screw and plate in the treatment of odontoid process fracture combining atlauto-axial dislocation.Methods　Twelve cases of odontoid process fracture were analyzed, there were 8 cases with type Ⅱ and 4 cases with type Ⅲ, all cases combined atlauto-axial dislocation, all cases must be reduced through preoperative drawing of skull for 5～7 days, all cases were treated with posterior internal fixation through lateral pedicle by screw and plate in general anaesthesia.Results　Twelve cases were followed up for an average of 16.5 months.The dynamic radiography showed all cases had bony union, 10 cases of them had stable reduction and the rest 2 cases of atlauto-axial dislocation had been improved.The good rates of reduction is 83.33%.Conclusion　The technique could be acquired good stability in the treatment of odontoid process fracture, there were wide indications in contrast with the others ways of surgery.]]> 2018/10/22 8:15:02 LIANG Bin, LI Hong-yu, WEI Min-ke, et al. 621true ［Abstract］　Objective　To observe the changes of pulmonary function and transforming growth factor beta-1(TGF-β1) of bronchial asthma patients in acute asthmatics and stable asthmatics, and explore its clinical significance.Methods　The pulmonary function of 55 acute asthmatics and 50 stable asthmatics were measured, and the serum TGF-β₁ were measured with ELISA, thirty healthy persons were selected as the control group.Results　The serum TGF-β1 concentrations of acute asthmatics and stable asthmatics were significantly lower than that of the control group. The differences were both statistically significant（P<0.01，P<0.05）, The serum TGF-β1 concentrations of acute asthmatics was significantly lower than those of stable asthmatics and control group(P<0.01).FEV1%、FEV1/FVC of acute asthmatics were significantly lower than those of stable asthmatics and control group(P<0.01), FEF50、FEF75 had no significant difference between acute asthmatics and stable asthmatics(P>0.05).There was a positive significant correlation between the serum TGF-β₁ and FEV1%、FEV1/FVC、FEF50、FEF75(P<0.01).Conclusion　Serum TGF-β₁ level down has a direct relation with pulmonary hypofunction and asthma attack, which suggested that TGF-β₁ was a reliable indicator of airway inflammation degree. The indicator of small airway function FEF 50、FEF75 had no obviously change in acute asthmatics and stable asthmatics, stable asthmatics also had small airway function disorder, which suggested that there were continuous airway inflammation in stable asthmatics.]]> 2018/11/7 8:22:37 LI Ping, XU Ping, LIU Xiao-jing 620true ［Abstract］　Objective　To study the relationship between left ventricular hypertrophy(LVH) of essential hypertension and complex ventricular arrhythmia, in order to provide a basis for clinical diagnosis and treatment.Methods　Four hundred and thirty-two patients with essential hypertension (all in accord with the 2005 revised edition of hypertension prevention and treatment guidelines in China), according to LVH and age, were divided into LVH, non-left ventricular hypertrophy(non-LVH) and age ≥ 60 years old, <60-year-old. The color Doppler echocardiography (in accordance with the Society of American Echocardiography (ASE) recommended methods of measurement) and 24 h Holter monitoring were used in this study.Results　Complex ventricular arrhythmia occurrence rate in LVH group was as high as 33.76 percent, significantly higher than 9.82% in non-LVH group; the incidence of in the ≥ 60-years old group were higher than those in the <60 years old group (P <0.01).The LVH and complex arrhythmia were often combined with ischemic ST segment changes.Conclusion　The early active control of blood pressure in hypertensive patients is the key to reduce the occurrence of LVH, and prevention of ventricular complex arrhythmia, thereby reducing the occurrence of cardiac events.]]> 2018/11/7 8:22:37 WEN Yu-min, CHEN Bao-zhu 619true ［Abstract］　Objective　To probe into the death cause and relative dangerous factors for the patients with maintenance hemodialysis (MH).Methods　A retrospective analysis was made on the clinical and hemodialysis material for 122 patients with MH who had ever been treated in the hemopurification center of our hospital from January 2003 to December 2007.Results　Of 122 patients, 56 patients died, accounting 45.9%, in which 31 cases died of cardiovascular disease (55.38%), 9 cases died of serious infection (16.07%), 7 cases died of cerebrovascular disease (12.50%), 3 cases died of whole-body failure (10.71%) and 3 cases died of gastrointestinal hemorrhage (5.36%). The dangerous factors, such as anaemia, hypertension, diabetes mellitus, malnutrition, low blood pressure and hyperkalemia etc, also had close relation with the death in hemodialysis.Conclusion　The cardiovascular disease and serious infection are the main factors caused the death of patients with MH. The thorough hemodialysis, active control of relative dangerous factors and effective prevention for complications can drop the death rate and improve the quality of life.]]> 2018/11/7 8:22:37 YE Zheng-hua, XU Di 618true ［Abstract］　Objective　To investigate the protective effect of tongxinluo therapy on vascular endothelium of hypertensive rats.Methods　Two groups of twenty male spontaneously hypertensive rats were studied：ten with the tongxinluo therapy(TXL group) and ten without any treatment (SHR group). Another one group of ten male homogeneously healthy rats were introduced as the normal controls(WKY group).The concentration of NO, ET-1，VEGF in aortic wall and gene expression were measured by reverse transcription-polymerase chain reaction(RT-PCR).Results　The NO level in SHR group were lower than those in both TXL and WKY group，while ET-1 level in SHR and TXL group were higher than that in WKY group （P<0.05）， but the gene expression of VEGF in SHR group were the highest（P<0.05）.Conclusion　Tongxinluo may have the protective effect on vascular endothelium of hypertensive rats.]]> 2018/11/7 8:22:37 GE Xiao-li 617true ［Abstract］　Objective　To discuss the clinical curative effect and the poisonous side reaction of 192 hour continuous drop of fluorine uracil (5-FU) by micro pump in the treatment of malignant nutrient cell tumor.Methods　Thirty-five malignant nutrient cell tumor patient received 192 hours continuous drops of 5-FU, the 1～8th day plan treatment;32 malignant nutrient cell tumor patient received convention vein drop of 5-FU, the 1～8th day plan treatment; and the clinical contrast observation were performed.Results　The effective rate in continuous drop group was 51. 4%， the effective rate in conventional vein drop group was 25. 0%, the difference in of curative effect between two groups had significance.Compared with the continuous vein drop group, the poisonous side reaction (mainly marrow suppression, nausea vomit and so on) rate of the conventional vein drop group was higher.Conclusion　The clinical curative effect of continuous drop of the 5-FU in the treatment of malignant nutrient cell tumor surpasses the conventional drop treatment； the poisonous side reaction is obviously lower than the conventional drop treatment.]]> 2018/11/7 8:22:37 YU Ying, ZHANG Qun-gui 616true ［Abstract］　Objective　To approach the relationship between the times of operation, needling frequency and the body position with complications in the amniocentesis by B ultrasonic-guidance, in other to get the good experience for the future.Methods　The retrospective analysis were used for comparing the times of operations, the frequency of needling on one time and the body position with complications about 406 cases of amniocentesis by B ultrasonic-guidance in our hospital.Results　The incidence rate of nervous shock induce pain was higher if the needling repeatedly increased than one time, and the percentage of late abortion was obviously high, the difference was highly significant （P<0.05）. The incidence rate of hypogastric vague pain was obviously high when the gestational women undergone two times of amniocentesis than once, the difference were significant （P<0.05）. The incidence rate of postural hypotension was higher when taking supine position than semi-reclining position and the difference was highly significance （P<0.05）. Conclusion　Although the amniocentesis is an invasive operation in the gestational diagnosis, but if we operate it according to the routine and correct skill, reducing the times of operation, taking the related body position, the amniocentesis is still a safe micro- traumatic operation.]]> 2018/11/7 8:22:37 TIAN Mao, WAN Li-kai 615true ［Abstract］　Objective　To observe the clinical effect of xueshuantong in treatment of patients with acute cerebral infarction(ACI) and its influence on hemodynamics. Methods　One hundred and five cases with ACI were divided randomly into treatment group and control group, receiving treatment of xueshuantong and fufang danshen injection respectively. The clinical efficacy were observed of two groups, and transcranial doppler(TCD) were examined before and after treatment.Results　The improving rate of treatment group was significantly higher than that of control group(50.9% vs 28.8%, P<0.05). The total effectiveness rate of treatment group was significantly higher than that of control group (86.8% vs 61.5%, P<0.01). Comparied with those before treatment, the indices of TCD in treatment group improved obviously after treatment （P<0.01 or P<0.05）, and had significant difference from control group (P<0.01). Conclusion　Xueshuantong is effective and safe for ACI, and can obviously improve the indices of hemodynamics.]]> 2018/11/7 8:22:37 HUANG Hui-bing, JIANG Li-zhen 614true ［Abstract］　Objective　To compare the reactions of induction and analepsia period between TIVA with propofol-sufentanil and TIVA with propofol-fentanyl in laparoscopic cholecystectomy.Methods　Sixty ASAⅠ-Ⅱpatients (27male, 33female) aged 35～60（41.2±6.8）years, weighed 45～70(61.5±5.9)kg, undergoing laparoscopic cholecystectomy were divided randomly into group sufentanil (S, n=30) and group fentanyl (F, n=30), group S receive sufentanil 0.3 μg/(kg·h), group F receive fentanyl 2μg/(kg·h), which was stopped at 30 min before the end of operation. Each group given propofol 6 mg/(kg·h), which was stopped at 10 min before the end of operation. Two groups were given PCIA. The following data were recorded and compared between the two groups:（1）The changes in BP and HR during tracheal intubation and induction; (2) Consumption of propofol, analepsia and extubation time, consciousness recovery and (3)VAS in postoperation.Results　（1）During tracheal intubation and induction the changes of BP and HR were significantly greater in group F than that in group S（P<0.05）； (2) Consumption of propofol was less in group S than that in group F(P<0.01)； （3）Analepsia and extubation time in group S was faster than those in group F(P<0.01)； （4）Consciousness recovery and VAS after operation were significantly better in group S. Conclusion　TIVA with propofol-sufentanil suits to laparoscopic cholecystectomy and recovery from anesthesia with propofol-sufentanil is faster and stabler than that with propofol-fentanyl.]]> 2018/11/7 8:22:37 BI Jing-bin, XIE Wei-nong 613true ［Abstract］　Objective　To investigate the effects of continuous blood purification(CBP) on coagulation function in patients with multiple organ dysfunction syndrome(MODS). Methods　Thirty-nine patients with MODS(21 males，18 females)aged 40～97years received CBP.All patients met the criteria of MODS. High volume continuous venovenous hemofiltration(HV-CVVH)was performed. MAP, HR, CVP, cardiac index, PaO₂/FiO₂ , PT, APTT, FIB, PLT were measured and recorded before (baseline)and at 4、12、24、48 h and 72 h after CBP.APACHEⅡ score were recorded before (baseline)and at 24、48 h and 72 h after CBP. There was control group which composed of twenty-five patients with MODS treated with conventional methods without CBP.Results　Compared with the baseline values before CBP PaO₂/FiO₂ and cardiac index were significantly increased at 4 h after CBP (P<0.05).The time of mechanical ventilation and the use of vasoactive agents were decreased in group with CBP treatment (P<0.05).APACHEⅡ score were significantly decreased after CBP(P<0.05). There was no significant change between low-molecular-weight heparin group and group without heparin (P>0.05).Conclusion　CBP can improve hemodynamics and oxygenation function, keep the balance of the coagulation-fibrinolysis system, so that CBP therapy is effective for patients with MODS.]]> 2018/11/7 8:22:37 XIONG Bin, LIN Yong-jun 612true ［Abstract］　Objective　To explore the changes and clinical significance of serum myocardial enzymes in children with pneumonia combined with heart failure.Methods　Forty-one children with pneumonia combined with heart failure who were treated in our hospital were selected as observation group.Thirty-two children with pneumonia in the same duration were selected as control group. Serum myocardial enzymes in the two groups were analyzed retrospectively.Results　Compared with control group, the level of CK, CK-MB, LDH, α-HBDH and AST in observation group were significantly higher (P<0.05 or P<0.01). The level of AST in the restoration stage in observation group was significantly decreased than that in acute stage(P<0.05), and though the levels of other myocardial enzymes were also downtrend, the differences between acute stage and restoration stage were no statistical significance (P>0.05).Conclusion　Myocardial enzymes can reflect the impaired degree of cardiac muscle in children with pneumonia combined with heart failure.The high level of CK-MB is a key index in the evaluation of ardiac damage. To examine in time and treat actively can reduce the happening of complication, elevate the achievement ratio of rescue and reduce the death rate.]]> 2018/11/7 8:22:37 MOU Jing-fei 611true ［Abstract］　Objective　To investigate the effect of midazolam in treatment of convulsive status epilepticus(CSE) in children.Methods　Seventy-two cases of children with CSE were randomly divided into two groups: Treatment group (38 cases) were treated by intravenous infusion of midazolam 0.3 mg·kg^-1 first, and then given continuous intravenous infusion of midazolam by the injection pump, the initial dose was 2μg·kg^-1·min^-1, and increasing 1 μg·kg^-1·min^-1 for every 15 minutes, the maximum dose reached 10 μg·kg^-1·min^-1, after the convulsions stopped, the drug continue maintained for 24 hours. Control group treated by intravenous injection of diazepam 0.3 mg·kg^-1, the maximum dose was not exceeding 10 mg, if the convulsions did not stopped or occurred another convulsion, re-injected the same dose of diazepam after 15 minutes, and treated by intravenous injection of phenobarbital 20 mg·kg^-1 in the same time, the maintainous dose of 5 mg·kg^-1 was given by intramuscular injection 12 hours later.Results　（1）There were 35 cases whose convulsions were completely controlled, and 3 cases were invalid in treatment group; And there were 25 cases whose convulsions were completely controlled, and 9 cases were invalid in control group(P<0.05); （2）It took (8.2 ± 4.1)h for treatment group to fully recover, and (14.3 ± 6.7)h for control group(P<0.01); （3）It took (38 ± 23) minutes for treatment group to control CSE, and (48 ± 29) minutes for control group(P<0.05); （4）Intravenous injected loading dose of midazolam only caused transient heart rate and blood pressure drop.Conclusion　The effect of midazolam in treatment of CSE in children was positive.]]> 2018/11/7 8:22:37 SU Ping, CHEN Bei, CAI Xia 610true ［Abstract］　Objective　To investigate the ventilation effect and clinical efficacy of early high frequency oscillatory ventilation (HFOV) in the treatment of neonatal respiratory distress syndrome (RDS).Methods　Forty-six children patients with RDS were randomly divided into two groups. Of them, 23 children patients were treated with HFOV(HFOV group), 23 children patients with normal frequency mechanical ventilation (CMV) treatment(CMV group).The lung function, the clinical efficacy and complications in two groups were compared.Results　In HFOV group the arterial oxygen pressure (PaO₂) and arterial carbon dioxide (PaCO₂) underwent changes at 2 h of the treatment.After 6 h after treatment, oxygen concentration (FiO₂), oxygenation index (OI) were significantly decreased; arterial/alveolar oxygen partial pressure (a/APO₂) significantly increased. Compared with those before treatment there was a significant difference (P<0.01).In CMV group, compared with those before the treatment, there is a significant difference in PaO₂, PaCO₂ and OI and other indicators after 6 h of treatment (P<0.05);When the treatment reached to the same time, HFOV group compared with the CMV group,there was significant difference in above indexes between two groups (P<0.05 or P<0.01).The incidence of bronchop ulmonary dysplasia (BPD) and pulmonary barotrauma complications in HFOV group were lower than those in CMV group. There was significant difference (P<0.05).In survival children, the time of oxygen therapy and hospital stay in HFOV group were shorter than those in the CMV group, the difference was significant (P<0.05).Conclusion　Compared with CMV,HFOV has advantages such as faster,and better, oxygenation improvement in children with RDS function, better ventilation effect, shortern course of disease, and less incidence of complications. It has good efficacy in the treatment of early RDS.]]> 2018/9/10 8:34:49 LIANG Wu-hua 609true ［Abstract］　Objective　To investigate the risk factors for stroke in young people. Methods　The risk factors of 103 cases of young stroke in our hospital,from January 1999 to June 2009，were analyzed retrospectively.Results　The risk factors for stroke in young people mainly were high blood pressure, high cholesterol, increased Lp (a),and heart disease; other factors were diabetes, family history, alcohol, smoking, history of stroke and so on. Young people with stroke at 30 to 45-year-old was in the majority (84.6%), and the number of male patients was more than that of female patients.Conclusion　The causes of young stroke are complex and diverse. The intervention of its risk factors can furthest reduce the incidence and recurrence rate of young stroke, improve the prognosis and improve living and health levels.]]> 2018/9/10 8:34:49 LUO Qing-yan 608true ［Abstract］　Objective　To observe the clinical efficacy of recombinant human interleukin-2 in the prevention of recurrence of condyloma acuminatum.Methods　The patients were divided into the treatment group and the control group randomly.All the patients treated with CO₂ laser and local recombinant human interferon α-2b cream,three times a day for 3 months.The patients of the treatment group were additionally injected locally with the recombinant human interleukin-2, 1 million u per week for 10 weeks.The relapse rates of two groups were observed at 3,6 months after treatment.Results　The recurrence rate of the two groups had statistically significant differences (P<0.05).The recurrence rate of treatment group was lower than that of the control group.Conclusion　Local injection of recombinant human interleukin-2 can reduce the recurrence rate of condyloma acuminatum.]]> 2018/9/10 8:34:49 WEN Wu-jian 607true ［Abstract］　Objective　To study the cause,treatment and effect of reoperation after craniotomy in the patients with severe craniocerebral injury.Methods　The clinical data of the reoperation after craniotomy in 29 patients with severe craniocerebral injury were retrospectively analyzed.Results　According to GOS，good outcomes were achieved (GOS Ⅴ) in 4 patients,moderate disability (GOS Ⅳ) in 7 patients,severe disability (GOS Ⅲ) in 5 patients,vegetative status(GOS Ⅱ) in 4 patients, death (GOSⅠ) in 9 patients. Conclusion　Most of the patients with severe craniocerebral injury undergoing reoperation have multiple combined injuries， high disability rate and death rate. The timely and correct operation， strict montioring and proper treatment of combined injuries could improved the patients′prognosis.]]> 2018/9/10 8:34:49 LU Jian,LI Wen-qian,HUANG Guo-zhou,et al. 606true ［Abstract］　Objective　To investigate the clinical distribution and drug-resistance of Acinetobacter baumannii in hospital, so as to provide evidence for proper use of antibiotic drugs in clinics.Methods　A total of 669 Acinetobacter. baumannii strains clinically isolated from Jan 2007 to December 2009 was retrospectively analyzed. The data were analyzed by Whonet 5.4 software.Results　The most location of Acinetobacter baumannii were ICU(44.9%) and respiratory ward(22.8%). The isolation rate of respiratory samples were the highest(73.4%). Acinetobacter baumanii had the highest susceptibility to cefoperazone/sulbactam, followed by imipenem. It had higher degree of drug resistance rates to the other antibaeterials, and had higher multidrug-resistantce.Conclusion　The drug-resistance of Acinetobacter baumannii shows a remarkable uptrend. It should be paid more attentions to the problems of multi-drug resistant and pan-resistant Acinetobacter baumannii.]]> 2018/9/10 8:34:49 CHEN XING-chun, LIANG Liang, ZHAO Li 605true ［Abstract］　Objective　To study the risk of recurrence after a first unprovoked seizure and analyze the potential predictors of recurrence.Methods　Sixty-six patients having a first unprovoked seizure who attended our hospital from October 1998 to June 2007,were followed up for 2 years. Recurrence rate was estimated by Kaplan-Meier curves. Univariate and multivariate analyses of the potential predictors of recurrence were performed for the first unprovoked seizure patients using the Cox proportional hazards model.Results　Sixty-six first unprovoked seizure patients had 36 relapses in two years, with the recurrence rate 54.55%. Cox Univariate and multivariate analyses showed that symptomatic etiology increased the risk of recurrence, and other predictors of recurrence included abnormal electroencephalogram，the occurrence of seizures during sleep and first seizure lasting longer than 10 minutes， whereas an age of 3 to 12 years decreased this risk.Conclusion　The recurrence risk after the first unprovoked seizure is lower than those who have two or more recent seizures. Several factors enable us to predict the recurrence risk after a first unprovoked seizure.]]> 2018/9/10 8:35:16 ZHANG Li-pan,WU Wei 604true ［Abstract］　Objective　To evaluate the diagnostic value of detection of HLA-B27 in spondyloarthropathies patients by flow cytometry.Methods　Two hundred and forty-eight patients with spondyloarthropathies and 204 patients with other rheumatic diseases were enrolled.In the 248 patients with spondyloarthropathies，there were 148 patients with AS，48 patients with USpA，31 patients with ReA，12 patients with JSpA，6 patients with PsA， 3 patients with EA.452 patients had HLA-B27 detection by flow cytometry.Results　In HLA-B27 detection by flow cytometry in the patients with SpAs，The sensitivity was 85.1% and specificity was 94.1%，the positive forecast value was 94.6% and negative forecast value was 83.8%.In the patients with AS，The sensitivity was 93.2% and specificity was 94.1%，the positive forecast value was 94.5% and negative forecast value was 92.7%. In the patients with USpA， The sensitivity was 77.1% and specificity was 94.1%，the positive forecast value was 92.5% and negative forecast value was 81.3%.In the patients with ReA, The sensitivity was 71.0% and specificity was 94.1%，the positive forecast value was 91.7% and negative forecast value was 78.0%.Conclusion　HLA-B27 detection by flow cytometry have higher sensitivity and specificity to diagnose SpAs，AS，USpA，ReA.]]> 2018/9/10 8:35:16 ZHU Xia, LAN Jiao,LIN Jin-ying, et al. 603true ［Abstract］　Objective　To observe the therapeutic efficacy of bailing capsule combined with pancreatic kininogenase(PK) in the treatment of early diabetic nephropathy (EDN), and the changes of urinary micro-albumin. Methods　Fifty cases of EDN were randomly divided into two groups.On the bases of routine therapy， the comparison group took PK 240 U, 3 times a day orally. On the basis of the comparison group, the combined treatment group took bailing capsule 1.0 g, 3 times a day orally. The changes of 24 h urinary albumin excretion rate(UAER) in the combined treatment group and the comparison group were observed before and after 12 weeks or 6 months of treatment. Results　The 24h UAER of the two groups were all decreased (P<0.05) after 12 weeks；after 6 months, the 24 h UAER of the comparison group were decreased (P<0.05)， and that of the combined treatment group decreased more significantly (P<0.01)； there was significant difference between the two groups after 12 weeks or 6 months of treatment (P<0.05). Conclusion　Bailing capsule combined with PK could significantly reduced urinary micro-albumin excretion of EDN patients and effectively delay the progress of DN.]]> 2018/9/10 8:35:16 MENG Guan-yun 602true ［Abstract］　Objective　To investigate the correlation between morning blood pressure surge and resting heart rate, and the influence on target organs in patients with essential hypertention. Methods　According to 24 h ambulatory blood pressure monitoring profiles, 88 cases were divided into morning blood pressure surge group (surge group) and morning blood pressure normal group (normal group). The levels of cholesterol, body mass index (BMI), left ventricular mass index (LVMI) were detected. HOLTER were used for recording the RHR. Results　The blood pressure of whole day, day and night in surge group were significantly higher than those in normal group. Morning systolic blood pressure-variability was significantly higher. LVMI and RHR in surge group were higher than those in normal group (P<0.05). There was no differece between two groups in age, BMI (P>0.05). Conclusion　Morning blood pressure surge can increase RHR, and LVMI also increase obviously. So lowering the morning blood pressure surge is a sensible way in hypertension management.]]> 2018/9/10 8:35:16 FANG Ling, GAO Chao, BAO Guo-ping, et al. 601true ［Abstract］　Objective　To evaluate the effecacy of xuebijing injection on patients with burns concomitant with sepsis.Methods　One hundred and twenty patients with burns concomitant with sepsis were randomly divided into therapy group and control group,and both were treated with conventional therapy.The therapy group was given xuebijing injection 100 ml intravenous drip twice daily for 7 days in addition.Before and after therapy,the changes of PCT,CRP and WBC in all patients were observed.Results　The levels of PCT,CRP and WBC in the therapy group were improved significantly after therapy,but the levels of PCT,CRP and WBC in the control group were non significantly changed.The incidence of complication of therapy group was lower significantly than that of the control group.Conclusion　Xuebijing injection possesses antagonistic effect on inflammatory factor in sepsis,and can improve the prognosis of patients with burns concomitant with sepsis.]]> 2018/9/10 8:35:16 LUO Ge-nan，YAN Li-qun 600true ［Abstract］　Objective　To evaluate the effect of sufentanil anesthesia in painless gastroscopy.Methods　Eighty patients were randomly divided into two groups: sufentanil group (S,n=40) and fentanyl group (F,n=40). Total intravenous anesthesia was induced either with sufentanil 0.15 μg/kg propofol 2 mg/kg or fentanyl 1 μg/kg propofol 2 mg/kg. The anesthesia effcet was evaluated. The analgesic degree, the blood pressure, heart beats,breathing was monitored before anesthesia, during operation and 30 minutes after operation respectively. The intervals of operation, consciousness recovery, staying in operation room were recorded.The side effect such as nausea and vomitting was also observed during operation and followed for 4 hours after operation.Results　There was significant difference in VAS scores at 30 minutes and 4 hours after operation (P<0.05) between two groups. There were not significant difference in the dose of propofol, the anesthesic degree during and after operation, blood pressure,heart beats and side effect between two groups（P>0.05）.Conclusion　Sufentanil can be administered in painless gastroscopy. The intervals of anesthesia was longer and comfortable sense was better as compared with fentanyl.]]> 2018/9/10 8:35:16 BI Jing-bin, YIN Xue-jun 599true ［Abstract］　Objective　To study the clinical features, related factors and prognosis of the elderly patients with chronic heart failure (CHF) concomitant with depression.Methods　Fifty patients who were confirmed as the elderly patients with CHF concomitant with depression were chosen as the observation group;another 58 elderly patients with CHF who were not accompanied by deprssion were chosen as the control group. The clinical characteristics, family and social support as well as the results of Holter monitoring of two groups of patients were analyzed.Results　There were significant difference between two groups in the incidence of severe sleep disorders, anxiety, agitation, depression, and decreased interest. The rates of family harmony and social support in the control group was significantly higher than those in the observation group. Holter monitoring showed the incidence of ventricular arrhythmias atrial arrhythmia and sudden cardiac death in the observation group were significantly higher (all P<0.05).Conclusion　Elderly patients with CHF concomitant with depression are prone to produce the symptome such as serious sleep disorder, anxiety, agitation, depression and so on; the incidence of sudden cardiac death in elderly patients with CHF concomitant with depression is higher; a good family and social support is helpful in preventing and reducing the occurence of depression in elderly patients with CHF.]]> 2018/9/17 8:12:27 LIANG Ji-ying, HU Cai-you, LV Ze-ping, et al. 598true ［Abstract］　Objective　To observe the curative effect of the carotid artery injection of Ginkgo biloba leaves injection on cerebral infarction.Methods　One hundred patients with cerebral infarction of internal carotid artery system were randomly divided into the treatment group (50 cases) and the control group(50 cases).The treatment group was treated with carotid artery injection of Ginkgo biloba leaves injection, the control group received intravenous infusion of Xuesaitong injection.Results　In the treatment group and control group, the total effective rate was 92% and 78% respectively.The therapeutic effect in the treatment group is better than that in the control group (P<0.05).Conclusion　The carotid artery injection of Ginkgo biloba leaves injection in treatment of cerebral infarction has satisfactory effect and doesn′t have significant adverse reactions.]]> 2018/9/17 8:12:27 LIN Pei，ZHANG Luan-jiao 597true ［Abstract］　Objective　To explore the affection of two different fixation methods of deep venous catheter on deep venous catheter-related infections. Methods　Two deep catheter cases were observed. Of which 100 patients were observed for the simple suture fixation; another 100 cases were used for the control group for conventional fixation; each case was collected swab of preceding 3 cm of catheter and 3 cm skin surrounding puncture point， contralateral venous blood 10 ml for common bacterial culture. The total collections were 600 specimens. The cases of localized skin infections after intubation, the positive cases for bacterial culture of preceding catheter, the positive cases for bacterial culture of peripheral blood and the results of strains of bacterial culture were recorded respectively and analyzed. Results　The positive rate of bacterial culture of swab of preceding deep venous catheter and skin surrounding puncture point was obviously higher than peripheral blood（χ²＝19.205，P<0.05 ） ， the bacterial culture pathogens of the swab of deep venous catheter and surrounding skin of puncture point were absolutely advantaged in G⁺ coccobacteria. Both positive strains of bacterial culture were consistent with a higher rate, suggesting that catheter-related infections were exogenous. The average time of stay was (29.97±12.81) days in observation group and （18.95 ± 10.79）days in control group respectively. The difference was statistical significance （P<0.05）. The positive rate of bacterial culture of skin surrounding the puncture point, preceding catheter and peripheral blood between two groups had significant difference (P<0.05). Conclusion　The pathogens of deep venous catheter-related infections mainly come from the normal skin bacteria colonization. Simple suture fixation to immobilize deep venous catheters has a certain role in reducing catheter-related infections and extending retention time of deep venous catheters, worthy of clinical practice.]]> 2018/9/17 8:12:27 FENG Yu-dong,SU Shu-yun,CAI Xiao-yan 596true ［Abstract］　Objective　To understand the appilcation of Gap-PCR and reverse dot-blot hybridization techniqne in the detection of α-thalassemia.Methods　The gap PCR (or Gap-PCR) detection was used for deletional α-thalassemia, reverse dot-blot hybridization for non-deletional α-thalassemia.Results　Of 3896 specimens, 237 cases of α-thalassemia were detected and the detection rate was 6.08 percent. By Gap-PCR technique, 56 cases of deletional α-thalassemia were detected and genotypes were : missing in Southeast Asia type (--^SEA), the right side of deletional (-α^3.7) and the left side of deletional (-α^4.2); 4 cases of HbH were found. Through reverse dot blot hybridization,8 cases of non-deletional α-thalassemia were detected and genotypes were: αα/α^QS and αα/α^WS.Conclusion　α-thalassemia is a common genetic disease with greatest influence in southern China, and the hematology screening and genetic diagnosis of thalassemia should be strengthened to improve the diagnosis rate.]]> 2018/9/17 8:12:27 QIN Gui-fang,ZHOU Ying,LIU Xin, et al. 595true ［Abstract］　Objective　To explore surgical approaches and efficacy of microsurgery in turberculum sellae meningiomas. Methods　A retrospective analysis was made on 23 cases of turberculum sellae meningioma operated.Results　The tumors were operated on with 3 different surgical approaches depending upon its size on CT or MRI. Complete resection was achieved in 17 cases, subtotal in 6 cases.Postoperatively， well recovery were found in 19 cases， moderate disability in 2 cases， recurred tumor were found and reoperated in 2cases.Conclusion　Selecting the proper operating approach and protecting the major structures near the tuberculum sellae meningiomas is the key to total remove of turberculum sellae meningiomas and improve the prognosis in the patients.]]> 2018/9/17 8:12:27 XIAO Quan, LAN Sheng-yong, TANG Xiu-wen, et al. 594true ［Abstract］　Objective　To explore the changes of serum cystatin C in neonate with asphyxia,and evaluate its effect on function of glomerular filtration.Methods　Serum cystatin C,blood urea nitrogen(BUN) and creatinine(Cr) of neonates in asphyxia group and of neonates in the control group were measured by enzyme-linked immunosorbent assay (ELISA).Results　Cystatin C obviously inreased in neonates with asphyxia,compared with control group. There were no significant difference in serum BUN and Cr levels between the mild asphyxia group and the control group. Levels of serum cystatin C was incrased in severe asphyxia.Serum CysC levels in the asphyxia group were significantly higher than those in the control group(P<0.01).After the treatment, levels of serum cystatin C decreased.Conclusion　Serum Cys C can be considered as a marker of damage function of glomerular filtration in neonates with asphyxia.]]> 2018/9/17 8:12:27 ZHANG Jian, TANG Cheng-he, LI Shu-jun 593true ［Abstract］　Objective　To analyze the safety and therapeutic efficacy of laparoscopic decollement of mature ovarian teratoma. Methods　One hundred and eighty patients with mature ovarian tecatima received laparoscopic decollement of mature ovarian teratoma in our hospital from March 2004 to March 2008. First, a single-stage coagulation was used in ovarian surface there is no blood vessels to incise a about 1～2 cm incisions. Then the envelope was separated and torn along the incision with forceps, and the tumor capsule and envelope was gently separated. If the tumor was rupturd, the tissue outside the capsule should be drawn immediately. Results　In the group of 180 deallement of ovarian mature teratama, the operation time was 45～90 minutes, with an average of 60.5 minutes. The loss of blood was less than 20 ml. No patient was converted to laparotomy. Between 3～12 months of following up,no patients had tumor recurrence by Bultrasound examination, and all patients had normal menstruation. Conclusion　Laparoscopic decollement of mature ovarian teratoma is safe and reliable and less traumatic. The occurrence of intraoperative tumor rupture and operation time are primarily related to capsular thickness and surgical techniques.]]> 2018/9/17 8:12:27 LIU Gui-yu 592true ［Abstract］　Objective　To summarize the treatment effect, clinical features and control strategies of the elderly patients with condyloma acuninatum (CA). Methods　From June 2006 to June 2008, 121 elderly patients with CA were treated, 60 patients in the integrated therapy group were treated by integrated therapy methods (electrocoagulation treatment method, psychological interventions, improving the body immunity and local resistance); 61 patients in the control group were treated by simple electrocoagulation treatment method. Results　The cure rate, recurrence rate and complication rates in integrated therapy group were 88.33%、 10.00% and 8.33% respectively; The cure rate, recurrence rate and complication rates in electrocoagulation treatment group were 68.85%、 29.51% and 26.23% respectively. There were statistically difference between the two groups (P<0.01). Conclusion　The elderly patients with CA have the clinical features such as long duration, complex concomitant disease, low cure rate, high recurrence rate and the high complication and greater psychological impact, and so on. Comprehensive treatment can significantly improve the clinical efficacy.]]> 2018/9/17 8:12:27 ZHANG Hong 591true ［Abstract］　Objective　To observe the clinical effect of sodium ferulate combined irbesartan in the treatment of diabetic nephropathy at stage Ⅲ～Ⅳ.Methods　Sixty patients with diabetic nephropathy at stage Ⅲ～Ⅳ were randomly divided into the control group and the treatment group,with 30 cases in each group. Both groups were given diabetic diet, oral hypoglycemic drugs and insulin to control of blood sugar, and reached a good blood sugar levels. The control group was treated with irbesartan 150～300 mg, 1 time/d. On the basis of the above therapy,the treatment group was added sodium ferulate 300 mg/d intravenous infusion, 2 weeks as a course of treatment,the rest time was two days between the two courses of treatment, with a total of 2 courses. Before and after treatment the urine microalbumin (U-mAlb), 24 h urinary protein (U-Pro), serum urea nitrogen (BUN), serum creatinine (SCr), triglyceride (TG), total cholesterol (TC) were measured.Results　After treatment the levels of U-mAlb, U-Pro, BUN, SCr, TG and TC in two groups decreased, but those in the treatment group decreased more significantly.Conclusion　Irbesartan combined sodium ferulate in the treatment of patients with diabetic nephropathy at stage Ⅲ～Ⅳ is a more practical treatment methods, the combination of the two drugs can enhance the protective effect on kidney.]]> 2018/9/17 8:12:27 LI Yu-xia 590true ［Abstract］　Objective　To observe the effects of enteral and parenteral nutrition support for mechanical ventilation patients in ICU.Methods　Sixty patients with mechanical ventilation in ICU were randomly assigned to two groups: one supported with enteral nutrition (32 cases) and another with parenteral nutrition (28 cases). All patients received the same energy and same nitrogen. The levels of serum albumin, hemoglobin were detected, the ventilation time, the thickness of skin fold at musculus triceps branchii and muscular perimeter of the arm were measured, and the nitrogen equilibrium was calculated.Results　The levels of serum albumin and hemoglobin and nitrogen equilibrium were higher in enteral groups (P<0.05). No difference was observed in the thickness of skin fold at musculus triceps branchii and muscular perimeter of the arm between two group ( P>0.05)，and mechanical ventilation time in the enteral nutrition group was shorter than that in parenteral nutrition groups ( P<0.05).Conclusion　For ICU patients, enteral nutrition has a better effect in nutrition support and can shorten the ventilation time.]]> 2018/9/17 8:13:20 HAN Lin, XIONG Bin 589true ［Abstract］　Objective　To explore the effects of sports and optimal dietary structure on blood glucose in diabetic patients.Methods　One hundred and sixty-five cases with type 2 diabetes were randomly divided into two groups(drug plus sports and optimal dietary structure group and simple drug group). The fasting blood glucose and 2hours postprandial blood glucose before treatment and 1,2,3,4 months after treatment were determined.Results　Compared with the simple drug group, the decrease in fasting blood glucose and 2 hour postprandial blood glucose after treatment in the drug plus sports and optimal dietary structure group was more obvious.There was significantly difference between the two groups(P<0.01).Conclusion　Spots and optimal dietary structure could simultaneously decresed the level of fasting blood-glucose and the 2hours postprandial blood glucose and both are the important parts in compositive treatment of diabetes.]]> 2018/9/17 8:13:20 QIN Guo-zhen,QI Jin-ying 588true ［Abstract］　Objective　To study relationship between the histopathologic findings and imaging features on the CT of intrahepatic cholangiocarcinoma (IHCC). Methods　Twenty-two patients with pathologically proven IHCC were reviewed by CT scanning and pathology. Results　On unenhanced CT, the lesions showed round or oval tumor of low density with ill - defined border. Dynamic CT of typical IHCC showed the presence of thin, mild or incomplete rim-like contrast enhancement at the tumor periphery as well as delayed reinforcement. Macroscopically and microscopically, cholangiocarcinomas showed much carcinoma cell and a little fibrous tissue at the periphery but a lot of fibrous tissue in the center of the tumor. Conclusion　Thin contrast enhancement at the tumor periphery in arterial phase as well as delayed reinforcement is the typical performance because of the hyperplastic fibrous tissue. Lobulated or flower-like tumor in enhanced phase and intrahepatic biliary dilatation is IHCC specific performance in CT.]]> 2018/9/17 8:13:20 ZHU Zheng-chao 587true ［Abstract］　Objective　To analyze the incident rate of depression in type 2 diabetic patients and to investigate its influencing factors including age, gender, education level, financial situation and disease course. The type 2 diabetic patients with depression were treated with relevant intervention strategy to effectively control the development of the disease.Methods　Of All the type 2 diabetic patients who were assessed with a questionnaire and self-rating depression scale (SDS), those with depression were randomized into the intervention group and the control group. The patients in the intervention group, in addition to conventional therapy,were supplemented by health education，psychological counseling and fluoxetine.Results　Of the 334 type 2 diabetic patients, 138 (41.3%) patients were complicated with depression. A multifactor retrospective analysis was performed to determine the 7 risk factors including education level, income, physical labor intensity, mental intensity, leisure-time activities, course of diabetes, complications of diabetes. With the intervention treatment, the scores of FBG、2hPBG、HbA1c and SDS in the intervention group were significantly decreased than those in the control group（P<0.05）.Conclusion　A defined standard for the high risk individuals were established in the study to implement the intervention treatment under the physicians′ guidance to minimize the risk of the frequent depression in type 2 diabetic patients.]]> 2018/9/28 10:50:38 ZHANG Hai-guang, WANG Yan, WANG Xu-hui 586true ［Abstract］　Objective　To analyze the significance about detecting the fetal abnormal karyotype with the selection of indication for invasive prenatal diagnosis.Methods　One thousand, one hundred and thirty-three pregnant women accepted invasive prenatal diagnosis （amniocentesis or percutaneous umbilical blood sampling）in our hospital from July 2004 to September 2009 base on the different indications such as high risk maternal serum screening in the second trimester pregnancy, the age of pregnant woman≥35 years, the abnormal result by ultrasound measurement of fetal nuchal translucency or fetal ultrasound examination, bad pregnant or generational history（include spontaneous abortion, stillbirth, fetal death, fetal anomaly, birth defect）, and these indications were classified into single or multiple. The fetal karyotype analysis would be taken after cell culture from amniotic fluid or cord blood.Results　There were 38 cases with abnormal karyotype (3.35%) being detected in totally 1 133 cases. The different single indication with the detecting of abnormal karyotype were compared. The detecting rate of the autosome trisome in order was 5.0%（high NT）, 1.62%（the age of pregnant woman≥35 years）, and 0.49%（high risk in maternal serum screening）, the detecting rate of total abnormal karyotype from high to low was 11.76%（the history of fetal anomaly or birth defect）, 6.9% （fetal abnormal by ultrasound examination）, 5.9% （spontaneous abortion history）. In the multiple indication, the detecting rate of autosome trisome was 14.29%（the age of pregnant woman≥35 years & high NT）, 5.88%（the age of pregnant woman≥35 years & fetal abnormal by ultrasound examination）. The total detecting rate of abnormal kayotype was 17.56%.Conclusion　It is still a major route for detecting the fetal autosome trisome that taking the prenatal diagnosis to the pregnant women who will be 35 years or older on their due date. We suggest to pay close attention to the pregnant women who displayed fetal high NT or fetal abnormal in B ultrasound examination, having the bad pregnant & generational history, then hope to potentially detect the fetal who has chromosomal disease, in order to decrease birth defect.]]> 2018/9/28 10:50:38 TIAN Mao，WANG Lin，QIN Ting，et al. 585true ［Abstract］　Objective　To depress the factors of the infection in a hospital and probability from the occupational exposure of medical staffs in department of stomatology.Methods　By using the investigation, inquiry, and comparative detection (therapy instrument, the virus of the medical staffs′ hands, through blood spread disease) and the other methods.The obtained data were calculated and analyzed.Results　In 5 investigated medical enterprises of municipal level, the qualified rate of the oral instrument was 89.81%;the infection rates of the medical staffs′ bearing with anti-HCV and HBV was 2.7%,10.81% respectively.Conclusion　The status of the stomatology instruments and the occupational exposure of medical staffs can not be ignored, the effective control measure can depress the occurrence of the infection in a hospital and the occupational of exposure.]]> 2018/9/28 10:50:38 LIU Cai-xia,CHEN Shu-min, WANG Tao-e 584true ［Abstract］　Objective　To explore the application of sufentanil combined with ropivacaine for obstetric epidural analgesia in the cesarean section patient controlled epidural analgesia(PCEA). Methods　Ninety cases of cesarean section were randomly divided into three groups with spinal-epidural anesthesia, i.e. group A, group B and group C. There were 30 cases in each group. The patients received 0.2 μg/ml sufentanil combined with 0.125% ropivacaine in group A, 0.4 μg/ml sufentanil combined with 0.125% ropivacaine in group B and 0.6 μg/ml sufentanil combined with 0.125% ropivacaine in group C, respectively. Postoperative PCEA were performed through loading dose (5 ml) + continuous dose (3 ml/h) + PCA dose (1 ml/times). The data were analyzed on the VAS scoring of incision pain, uterine pain in the period of 0～3, 3～6, 6～12, 12～24 h postoperatively and the incidence of adverse reactions such as nausea, vomiting, itching, motor block, lethargy, respiratory depression in the period of 0～24 h postoperatively. Results　The incision pain VAS score and contraction VAS pain score decreased with sufentanil concentration increasing. The defference between Group B, group C and Group A had statistic significance(P<0.05). The defference between Group B and group C had not statistic significance (P>0.05). The rate of adverse reactions in the nausea and the incidence of itching increased with sufentanil concentration increasesing. The defference between Group C and group B, Group A had statistic significance(P<0.05). The defference between Group B and group A had not statistic significance(P>0.05). The incidence rate of vomiting, motor block, lethargy had not statistic significance(P>0.05) among the three group. No respiratory depression happened. Conclusion　In the cesarean section PCEA, 0.4 μg/ml sufentanil combined with 0.125% ropivacaine can get better analgesic effect and less side effects.]]> 2018/9/28 10:50:38 CHEN Shi-qing 583true ［Abstract］　Objective　To determine the clinical characteristics of schizoid disorder due to deep breath exercise and reactive schizoid disorder, provide scientific foundation for diagnosis, differential diagnosis and treatment of the two diseases.Methods　Twenty-six patients with schizoid disorder due to deep breath exercise (deep breath exercise group) and 59 patients with reactive schizoid disorder (reaction group) in our hospital from 1989 to 2006 were reviewed and compared in clinical characteristics.Results　Both were caused by mental factors. Onset of the disease was related to mental factors, unhealthy characters and, family history. All psychiatric symptoms of schizophrenia which were impacted by mental stimulation can be found in both groups. And the same treatments, marked therapeutic effects as well as good prognosis were found in both groups. Visual hallucination, hearing hallucination, feeling of being controlled, delusion of physical influence and conduct disorder were more common in reaction group than in deep breath exercise group.Conclusion　Similar factors, symptoms and treatments were found in deep breath exercise group (schizoid disorder due to deep breath exercise) and reaction group (reactive schizoid disorder).]]> 2018/9/28 10:50:38 LIU Cheng-wen, WEI Qing-ping, HU Long-shan 582true ［Abstract］　Objective　To investigate the effects of proton pump inhibitors (PPI)on levels of calcium regulating hormones and urinary calcium.Methods　Ninety-seven patients received PPI therapy for three months were recruited in this study. Blood levels of PTH，BPG，CT，serum tolal calcium and 24 hours urine calcium were measured before and after treatment.Results　There were no significant changes in level of PTH，BPG，CT and serum tolal calcium after therapy. The level of 24 hours urine calcium decreased after therapy compared with that before treatment.Conclusion　Short-term therapy with PPI can lead to the decrease of level of 24 hours urine calcium. The reason could be related to the inhibitory effect of PPI on calcium absorption.]]> 2018/9/28 10:51:43 LI Su-lan, YANG Rui-ping 581true ［Abstract］　Objective　To evaluate the diagnostic methods of duplex kidney and ureter in order to improve diagonosis of this disease.Methods　The clinical data of 23 patients with duplex kidney and ureter hospitalized in our hospita1 from March 1998 to August 2008 were retrospectively analyzed,of them 4 cases are male,19 cases were female;the age ranged from 9 to 36，the symptoms included lumbar/abdominal pain or masses in 10 patients,leakage of urine 5 patients, irritative symptoms of bladder 4 patients.Accessory examination included ultrasonic diagnosis in 23 patients,IVU 23 patients, RPG 13 patients, CT 16 patients, MRU 4 patients，all 23 patients were diagnosed as duplex kidney and ureter， all 23 patients were treated by surgery.Results　After operation all 23 cases were recovery，of them 17 cases were followed up for 6 months to 5 years，of them 1 case were found retroperitoneal urinary cyst,after operation this case were recovery; 2 cases were found mild uronephrosis and the sympotm was stable.Conclusion　The diagnosis of duplex kidney and ureter could be confirmed on the basis of clinical manifestation, ultrasonic diagnosis and IVU in some patients, but in the patient with severe uronephrosis and low renal function the poor result of IVU could lead to wrong diagnosis.RPG could find the reason and location of uronephrosis but it is an invasive examination.CT is a simple and fast examination,it could demonstrate the location of duplex kidney and ureter so it could provide useful information for operation.MRU examination has high accuracy and sensibility for the location of abnormal opening.The operation should be taken according to the location and complication of different patients.]]> 2018/9/28 10:51:43 ZHANG Xiong-wei, CHEN Qiang-wen, ZHOU Lian-xing, et al. 580true ［Abstract］　Objective　To investigate the clinical value of thin-layer liquid-based cytology (TCT) combined with colposcopy cervical biopsy in cervical lesions.Methods　Choosing 1 685 cases received screening of cervical lesions in our hospital in recent years，all patients underwent TCT testing，cytology was classified using TBS classification criteria， of them 128 cases with TCT positive line were checked multiple biopsy under colposcopy.Results　The rate of abnormal cytology-positive detection was 7.60% (128/1 685)，in which atypical squamous cells (ASCUS)，56 cases (3.32%)；low-grade squamous intraepithelial neoplasia (LSIU)，42 cases (2.49% )；high-grade squamous intraepithelial neoplasia (HSIU)，26 cases (1.54%)；cervical squamous cell carcinoma (SCC)，3 cases (0.18%)； cervical adenocarcinoma (ACC)，1 cases (0.06%). Colposcopy pathological diagnosis showed chronic inflammation in 48 cases, mild dysplasia (CINⅠ) in 41 cases，moderate dysplasia (CINⅡ) in 17 cases, severe dysplasia and carcinoma in situ (CINⅢ) in 18 cases ，cervical squamous cell carcinoma in 3 cases，cervical adenocarcinoma in 1 case.Conclusion　Using TCT in the screening of cervical lesions can significantly increase the positive rate，the joint of colposcopy and endoscopic biopsy can improve the diagnosis rate of cervical lesions，and detect early cervical lesions and cancer.]]> 2018/9/28 10:51:43 YU Shan-zhi,MA gang,WU Ji-fang 579true ［Abstract］　Objective　To investigate the clinical effects of different surgical methods in the treatment of patients with varicocele.Methods　The clinical data of 98 patients underwent the treatment of varicocele in our hospital from January 2000 to October 2009 were retrospectively analysed,ligation of spermatic vein via the inguinal canal in 46 patients, ligation of spermatic vein via retroperitoneum in 34 patients,and laparoscopic spermatic vein ligation in 18 patients.Results　There were no the differences in the relapse rate,the complications and postoperative fertile in ligation of spermatic vein via the inguinal canal,ligation of spermatic vein via retrospritoneun and laparoscopic spermatic vein ligation,the effects in hospitalizd time and improvement of semen quality in laparoscopic spermatic vein ligation were best than that in ligation of spermatic vein via the inguinal canal and ligation of spermatic vein via retrospritoneun.Conclusion　The above three suogecal methods in the treatment of the patients weth varicocele are effective,each has own advantages and disadvantages.]]> 2018/9/28 10:51:43 LIAND Zhi-xiang,JIANG Hong-chang,HUAND Mei-song, et al. 578true ［Abstract］　Objective　To understand the epidemiological characteristics of rabies exposure population in Qinnan area and provide scientific basis for rabies control strategy.Methods　From 2006 to 2008 the exposure population who were bitten or scratched by animals such as dogs and cats received rabies vaccination and outpatient treatment were investigated.Results　In the three years 13146 rabies exposure cases were reported,the average annual exposure rate was 113.82/10000. Male accounted for 62.06%,female 37.94%. Persons aged 20 to 49 years accounted for 65.32%. In all age groups, the number of persons whose upper and lower extremities were bitten by dogs was in the first two places.The head-face injury rate by dogs in 0～group was 25.37%, obviously higher than other groups. The number of persons injured by dogs in July and August was more than other months.In profession farmers accounted for 77.85%.Dogs accounted for 92.08% in the exposure animals. Third degrees injury accounted for 86.07% in the wounded persons who were actively bitted by dogs.After exposure, the number of persons whose wound were treated accounted for 97.13%.Of them the standard treatment accounted for 82.87%, non-standard for 17.13%. No treatment for 2.87%. Whole course rabies vaccine inoculation accounted for 90.84%. In third degree injury by dogs,the number of persons were treated by anti-rabies immunoglobulin and seurum accounted for 9.00% only. Conclusion　In Qinnan area, the effective measures for rabies prevention are taken, but there are still many risk factors. Only by the joint efforts of the relevant government departments, citizens and dog owners, the rabies outbreak can be effectively controlled.]]> 2018/10/8 8:27:44 LI Xia,SHEN Ping 577true ［Abstract］　Objective　To observe the effect of the 2∶1 ball-plasma ratio exchange transfusion therapy on routine blood of newborn with hyperbilirubinemia. Methods　From January 2005 to April 2009 76 newborns with hyperbilirubinemia in our department were treated with different ball plasma ratio exchange transfusion. Of them, the observation group(n=44) was treated with the 2∶1 ball-plasma ratio exchange transfusion;the control group(n=32) with the 1∶1 ball-plasma ratio exchange transfusion. Before and after exchange transfusion, bilirubin, WBC, RBC, hemoglobin and platelets were measured. Results　After exchange transfusion, RBC and hemoglobin (Hb) in the observation group increased, while RBC and hemoglobin decreased in the contyol group. There were significant difference betwten two groups(P<0.05). WBC and platelets in two groups decreased significantly(P<0.05). Conclusion　The 2∶1 ball-plasma ratio exchange transfusion treatment for severe hyperbilirubinemia can significantly reduce serum bilirubin levels and correct anemia, but easily lead to transient decrease of white blood cells and platelets after exchange trausfusion. Therefore, after exchange transfusion, it should be necessary to guard against the occurrence of infection and bleeding, and promptly take appropriate therapeutic measures to avoid serious complications after exchange transfusion.]]> 2018/10/8 8:27:44 WANG Zhao-kang,LIANG Dan-feng,WU Bao-zhen 576true ［Abstract］　Objective　To investigate the clinical significance of detection of serum cholinesterase(CHE) and prealbumin(PA) in all kinds of viral hepatitis patients.Methods　 The level of serum CHE and PA in 300 viral hepatitis patients and 30 healthy persons were monitored by false-CHE velocity and immunity nephelo-contrast method.Results　Compared with control group, the level of serum CHE and PA in all kinds of viral hepatitis patients were decreased to certain extent, The sort of degradation extent from high to low were posthepatitic cirrhosis→chronic severe hepatitis→subacute severe hepatitis→chronic hepatitis(heavy) →chronic hepatitis(middle)→acute icterohepatitis→chronic hepatitis(slight). The level of serum CHE and PA in hepatic cirrhosis patients gradually decreased from Child-pugh A grade to C grade, the difference of different grades was conspicuously. Conclusion　The level of serum CHE and PA are good indexs which can reflect the condition of hepatic function. They can provide the reference for hepatic cirrhosis grading in clinic and accurately judge the operation tolerance or prognosis of hepatic cirrhosis patient.]]> 2018/10/8 8:27:44 BAI Liu-jiang,XU Wei-feng,ZHANG Guo-dong 575true ［Abstract］　Objective　To discuss the clinical application of immunofluorescence dectection of serum C-reative protein in infectious diseases, cardiovascular diseases and other sorts of diseases.Methods　The immunofluorescence method adopted was in detecting C-reative protein in blood serum including hypersensitivity C-reative protein (hs-CRP) and normal C-reative protein (CRP).Results　In the infectious diseases in infants,when CRP>25 mg/L and hs-CRP>3.0 mg/L the proportion of bacterial inflammation (purulent meningitis, septicemia, abscess, omphalitis) were separately 77.3% and 95.5%. The proportion of the two groups was higher than those of common viral infection diseases (pneumonia, bronchopneumonia, upper respiratory tract infection, children enteritis) (6.2%, 27.4%,respectively) and those of virus-infected diseases (hand-food-mouth disease, CNS virus infection)( 0.0%, 51.6%, respectively),(P<0.05); the difference had significance in statistics. Other non-infectious diseases (such as bleeding of the gastro intestinal tract, asphyxia, premature birth, pulmonary edema) were mainly CRP<10 mg/L, hs-CRP<1.0 mg/L with the proportion of 98.7% and 83.1% separately. When the infants′ CRP<25 mg/L and hs-CRP<1.0 mg/L, the positive group of bacteria culture and the group of virus infection were close in proportion and the difference had no significance in statistics (P>0.05); when CRP<25 mg/L and hs-CRP>3.0mg/L, the group of bacteria culture had the distribution proportion of 22.9% lower than that in the group of virus infection( 51.6%),the difference had significance in statistics (P<0.01).When CRP>25 mg/L and hs-CRP>3.0 mg/L, the distribution proportion of the positive group of bacteria culture was higher than the virus infection,the difference had significance in statistics (P<0.05). For adults with infectious diseases, when CRP>50 mg/L, the access of fever accounted for 77.8%, pneumonia accounted for 68.7% and bronchopneumonia accounted for 13.3%. Trauma, rectum cancer and postpartum hemorrhage accounted for 78.6%, 75.0%, and 69.2% separately. For cardiovascular diseases, when hs-CRP>3.0 mg/L, the proportion was 47.2%, when hs-CRP ranged from 1.0 mg/L to 3.0 mg/L, the proportion was 33.3%, and when hs-CRP<1.0 mg/L, the proportion was 19.5%. Conclusion　Clinical application of immunofluorescence dectection of CRP and hs-CRP is extensive, especially for the diagnosis and treatment of infant′s and adult′s infectious diseases, and had significant reference value in valuating the dangerous level of cardiovascular diseases, which is sensitive laboratory guideline.]]> 2018/10/8 8:27:44 YAN Shan-huo,ZHUO Yong-guang 574true ［Abstract］　Objective　To observe the effect of gonadotropin-releasing hormone analog(GnRHa) treatment on secondary sex characteristicd, height, bone age, body mass index, predicted adult height(PAH) in boys with central precocious puberty (CPP).Methods　Twenty-eight boys with CPP were treated with GnRHa and exercises, and plus GH if nescessary.And secondary sex characteristics and the indexes of height,bone age, body mass index and PAH were evaluated.Results　After the treatment sex hormone returned to prophase of the youth, spermary dwindled,bone age was restrained, HtSDSBA increased from (-1.6±0.6) to (-1.1±0.7)（P<0.01）1 year later, and (-0.70±0.7) 2 years later （P<0.01）;PAH increased from（164.8±5.4）cm to（168.8±6.2）cm（P<0.01）, and（172.2±6.5）cm two years later（P<0.01）.Conclusion　GnRHa is effective in the reeatment of boys with CPP, and have no significant adverse reaction.]]> 2018/10/8 8:27:44 TANG Qing, CHEN Shao-ke, FAN Xin 573true ［Abstract］　Objective　To investigate the feasbility,operative points and the prevention of complications of transvaginal hysterectomy for large uterus.Methods　The transvaginal hysterectomy （TVH）for ≥12 weeks of gestation on the size of the uterus were performed in 31 cases in the Shoukang Hospital of Huangshan from August 2004 to August 2009,and compared with transabdominal hysterectomy(TAH) group (33 cases).Results　Compared with the TAH group,the TVH group had a significantly reduction in anus exhaution time and postoperative hospital stay（P<0.05）. There were no significant difference in operation time and volume of blood loss between the two groups （P>0.05）.Conclusion　With a skilled surgical technique,and mastering of the right indication,TVH for large uterus is safe,with minor trauma and rapid recovery.]]> 2018/10/8 8:27:44 CHEN Pei-yu 572true ［Abstract］　Objective　To investigate the diagnosis and treatment of ocular siderosis due to intraocular iron foreign bodies.Methods　The clinical data of 10 patients with ocular siderosis due to intraocular iron foreign bodies were retrospectively analyzed，X-ray examnation,CT and A/B-utrasonic scan were used before operation. The foreign bodies located at vitreous in 3 patients and at wall of eyeball in 7 patients. The vitrectomy were adopted and the iron-foreign bodies were extracted.Results　The iron-foreign bodies were extracted successly in all 10 patients.The visual function improved in 7 patients, no changed in 2 patients and descended in 1 patient after operation.Conclusion　The ocular siderosis due to intraocular iron foreign bodies is a severe disease that influence visual function,the most method is the examination should be performed comprehensively and carefully， and the foreign bodies should be extracted at once while foreign bodies were identified to rescue the visual function.]]> 2018/10/8 8:28:25 HAO Xiao-yan, WAN Xuan 571true ［Abstract］　Objective　To study maternal and neonatal thyroid hormonal status in pre-eclampsia.Methods　Maternal and neonatal thyroid hormonal status including thyroid-stimulating hormone(TSH), total thyroxin(TT4), free thyroxin(FT4), total triiodothyronine(TT3), free triiodothyronine(FT3) were tested and biophysical profile score(BPS) was performed at the time of admission.Results　TSH level was significantly increased in early-onset and late-onset pre-eclampsia with BPS significantly decreased. FT3 and FT4 level were significantly decreased in early-onset pre-eclampsia. Neonatal thyroid hormonal level was decreased in early-onset pre-eclampsia.Conclusion　Thyroid hormonal status of pregnancy with pre-eclampsia is abnormal and it has adverse effects on the development of the fetus.]]> 2018/10/8 8:28:25 CAI Feng-er,CAI Chun-fang 570true ［Abstract］　Objective　To compare retrospectively the therapeutic effects between anterior and posterior surgery in multilevel cervical spondylotic myelopathy(CSM) with 3 or more segments. Methods　In sixty-eight patients with multilevel CSM from Jan 2003 to Jan 2009, 33 patients were operated from anterior approach, with selectively decompression and bone grating with plate fixed (group A); 35 cases were operated from posterior approach, with decompressive laminectomy posteriorly or mon-open-door vertebral canal expansing laminoplasty (group B). All patients were scored with JOA evaluating system and measured the sagittal diameter of dural sac, calculated the recovery rate as well. Results　The follow-up period were 6 months to 4 years and 2 months, average was 1 year and 11 months. There were no statistical difference in JOA scores and sagittal diameter of dural sac between group A and B before operation(P>0.05); while after operation, there were significant difference between the two groups(P<0.05), the JOA scores and recovery rate of group A was higher than those of group B. Conclusion　Anterior and posterior approach were effective operations for multilevel CSM, however, the anterior approach were surpass than posterior approach in the therapeutic effects.]]> 2018/10/8 8:28:25 YIN Chao-xin, YAN Ai-min, LIU Wen-he 569true ［Abstract］　Objective　To observe the effect of local injection of recombinant human interferon α-2b combined with oral valaciclovir for the prevention of recurrence of genital herpes. Methods　The experimental group was treated with local injection of recombinant human interferon α-2b combined with oral valaciclovir in the treatment of genital herpes, and the control group was treated with oral valaciclovir, and all patients were followed up within 1 year after treatment, the clinical relapse rate was compared. Results　The relapse number within one treatment after year in the experimental group was significantly lower than that in the control group. The relapse rate between two groups were significant difference (P<0.01). Conclusion　Local injection of recombinant human interferon α-2b can significantly reduce the relapse rate of genital herpes.]]> 2018/10/8 8:28:25 HUANG Sheng-ping 568true ［Abstract］　Objective　To evaluate the status of drug resistance in Mycoplasma infection in urogenital tract,and provide evidences for clinical therapy. Methods　Mycoplasma from urogenital tract secretion samples （n=8 041） of our hospital were artificially cultivated and taken drug sensitive tests. Results　Positive rates of Mycoplasma was 44.86% （3 670 in 8 041）, among which ureaplasma urealyticum accounted for 84.11% (3 034 in 3 607), Mycoplasma hominis accounted for 0.75%(27 in 3 607), Mixed infextion accounted for 15.14%(546 in 3 607); resistances of Mycoplasma to 12 antibacterials reduced successively: ciprofloxacin 80.68%(2910/3607), gatifloxacin 58.28%(2102/3607), cravit 52.50%(1894/3607), erythromycin 42.20%(1522/3607), roxithromycin 33.40%(1205/3607), thiamphenicol 30.88%(1114/3607), clarithromycin 25.20%(909/3607), azithromycin 24.84%(896/3607), alicyclic- erythromycin 22.46% (810/3607), doxycycline 13.47%(486/3607)， minocycline 12.89%(465/3607)， josamycin 3.08%(111/3607). Conclusion　Ureaplasma urealyticum (Uu) is the most familiar pathogen in urogenital tract, which usually occurs between the ages 21and 30 years, relates to infertility. Resistance to Josamycin was the lowest, Minocycline and Doxycycline take second place.]]> 2018/10/8 8:28:25 QIU Xiao-xia 567true ［Abstract］　Objective　To explore the value of the tumor-free technique in laparoscopic colorectal radical resection.Methods　The data of 34 cases with colorectal cancer underwent laparoscopic radical resection with tumor-free technique were retrospectively analyzed.Results　All the cases (100%)had laparoscopic radical resection successfully. The operation time was 138～246 min, mean 184 min. The trocar site seeding had not been seen, only 5(14.7%) had recurrence or metastasis during a follow-up period of 3 to 24 months.Conclusion　The short-term effect of laparoscopic radical resection with tumor-free technique is equal to that of the ordinary open operation.]]> 2018/10/8 8:28:53 ZHANG Gui-nian, HUANG Shun-rong, FENG Ze-rong, et al. 566true ［Abstract］　Objective　To investigate the relationship between the levels of serum uric acid and uric micro-albumin and the morphology and degree of coronary stenostic lesions in patients with coronary atherosclerotic disease.Methods　One hundred and fifty- nine patients were divided into two groups according whether complex stenosis was present or not. The degree of stenosis was analysed in terms of coronary stenosis index as well. The levels of serum uric acid (UA)were detected,and levels of micro-albuminuria was expressed by urinary albumin-to-creatinine ratio (UACR).Results　There were significant differences between the patients with complex stenosis and those without in terms of UA and UACR (P<0.05). By the method of stepwise multiple linear regression and correlation, it is found that UA and UACR were linear related to the coronary stenosis index.Conclusion　The increased levels of UA and UACR can contribute to the complex stenosis and the degree of coronary stenostic lesion in patients with coronary artery disease.]]> 2018/10/8 8:28:53 HUANG Qun-ying, HUANG Xiao-ming, LIU Wei-hua 565true ［Abstract］　Objective　To study the relationship between impaired glucose tolerance（IGT）and obstructive sleep apnea syndrome (OSAS).Methods　Eighty-two patients with OSAS were divided into 2 groups, IGT group (n=43) and non-IGT group (n=39). Their sleep apnea monitoring indicators and body mass index(BMI) were identified and analyzed to research the relationship between IGT and OSAS.Results　The apnea-hypopnea index (AHI) and lowest pulse oxygen saturation (Lspo₂) of IGT group were lower than those of non-IGT group. And the BMI of IGT group was significantly higher than that of non-IGT group.Conclusion　There is a closely relationship between IGT and OSAS.]]> 2018/10/8 8:28:53 TIAN Jin-fang 564true ［Abstract］　Objective　To assess the value of 64-slice spiral CT in the diagnosis of coronary artery disease.Methods　Fifty-four patients with suspected coronary disease were received 64-slice spiral CT coronary artery imaging and conventional coronary angiography.Results　Set the results of conventional coronary angiography as criteria，the sensitivity and specificity of 64-slice spiral CT coronary artery imaging for the diagnosis of coronary artery were 96.1% and 94.2% respectively.Conclusion　64-slice spiral CT coronary artery imaging has higher accuracy for the diagnoses of coronary artery disease.It may work as a noninvasive approach for the examination of coronary artery disease and instruct the diagnosis and therapy of coronary artery disease.]]> 2018/10/8 8:28:53 WEN Zheng-wan,DU Duan-ming,YUAN Xu-chun,et al. 563true ［Abstract］　Objective　To discuss the change of cardiac function and concentration of CysC from before and after interventional therapy in patients with coronary artery disease. Methods　In 200 hospital patients with coronary artery disease in our hospital, the WMSI, LVEF, LVEDD and LVESD before and after interventional therapy were measured by echocardiography and the concentration of CysC in blood before and after interventional therapy were determined. Their results were compared. Results　WMSI and LVEF after interventional therapy were significantly better than before interventional therapy. LVEDD and LEVSD after interventional therapy were smaller than before interventional therapy.The concentration of CysC after interventional therapy was lower than before interventional therapy(P<0.05). Conclusion　Interventional therapy can improve cardiac function of patients with coronary artery disease,and cut down the concentration of CysC. The concentration of CysC was a univariate predictor of patients with heart failure.]]> 2018/10/8 8:28:53 LIU Wei-hua,PANG Zhen-yao. 562true ［Abstract］　Objective　To compared the clinical efficacy of artificial femoral head replacement (FHR) and artificial total hip replacement (THR) in the treatment femoral neck fractures.Methods　The 42 cases of femoral neck fractures randomly divided into two groups to use artificial FHR and artificial THR for replacement surgery for treatment.Results　The operative time,the incidence of post operative complications and the amount of blood between two groups were not significant difference (P>0.05).The excellent and good rate of FHR and THR were 90.9%, 95.0% respectively (P>0.05).Conclusion　Artificial FHR and the artificial THR can cure femoral neck fractures and are the ideal and reliable methods for treating femoral neck fractures.]]> 2018/10/8 8:28:53 LAI Ming-chun 561true ［Abstract］　Objective　To investigate the reason of drug-induced thrombocytopenia in pregnancy-induced hypertension(PIH).Methods　Eighty-three normal pregnant women, 181 PIH women, 29 normal unpregnancy women(control group) were studied. platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) were measured. When determination value was <80×10⁹ platelets the correct review were performed.Results　In 181 cases of PIH women there were 27 womens with significant platelet reduction, the reduced rate was 14.92%;In 83 normal pregnant women there were 2 women with significant platelet reduction, the reduced rate was 2.41%;The difference between two groups had statistical significance (χ²=9.1041,P=0.0026). MPV and PDW in PIH group and normal pregnant women group significantly higher than those in control group (P<0.05);MPV and PDW in PIH group were significantly higher than those in normal pregnant women group (P<0.05);PLT in PIH group was significantly lower than that in the control group (P<0.05). By hand or pre-dilution method, In 27 with significant platelet reduction 19 cases be corrected, accounting for 70.4%,the difference between two groups before and after correction had statistical significance (χ²=11.4183,P=0.0007).Conclusion　The diagnosis of thrombocytopenia in PIH women can be corrected by emergency pre-dilution method or manual count, the detection has a certain reference value on the development of PIH.]]> 2018/10/8 8:28:53 GAN Zhi-yuan 560true ［Abstract］　Objective　To analysis the value of microalbuminuria in the pridiction of the scope and extent of coronary artery disease in diabetic patients. Methods　Two hundred and forty-six patients (from January 2008 to June 2009) underwent coronary angiography were divided into diabetic group (163 cases) and non-diabetic group (83 cases), Their quantitative 24-hour urinary albumin, fasting serum creatinine, blood lipids, blood glucose and other biochemical parameters were detected and ambulatory blood pressure monitoring were performed. The differences of coronary angiography results between two groups were compared, the correlation between microalbuminuria and coronary artery disease were analysed. Results　Compared with non-diabetic group, hypertension, microalbuminuria increased significantly in diabetic group(P<0.01), and the positive rate of imaging, multivessel coronary artery disease were significantly higher (P<0.01). Microalbuminuria in diabetic patients showed a positive correlation with the severity of coronary artery disease. Conclusion　Appearance of microalbuminuria in diabetic patients appears to increase the severity of coronary artery disease.]]> 2018/10/8 8:28:53 ZHANG Xi-yuan, LIANG Wei-dong, CHEN Ting, et al. 559true ［Abstract］　Objective　To investigate the applicative effect of Coflex, a interspinal flexible fixation device, in the treatment of patients with lumbar spinal stenosis.Methods　After a positive but invalid conservative treatment, 46 patients with lumbar spinal stenosis were selected and randomly divided into control group and test group, with 23 cases in each group. Test group received routine decompression and Coflex fixation while the control group received routine decompression and pedicle screw fixation and fusion. The operative duration, blood loss, postoperative time in bed and postoperative VAS score were compared and statistically analyzed.Results　Two groups were able to get a significant relief of back and leg pain; but the operative duration, blood loss, postoperative time in bed were significantly reduced in the test group than in the control group（P<0.05）.Conclusion　The interspinal Coflex elastic fixation was an effective way for the treatment of lumbar spinal stenosis.]]> 2018/8/27 8:16:11 GUO Zhi-yong, BAI Bo, YIN Zhi-xun, et al. 558true ［Abstract］　Objective　To investigate surgical styles and treatment effect of curing rectal evacuation disorder type constipation caused by moderate and severe degree rectocele and rectal internal mucosal intussusception.Methods　Thirty-two patients with moderate and severe degree rectocele and rectal internal mucosal intussusception were operated by quadruple therapy, including circular rectal mucosal resection and anastomosis with stapler, rectal antetheca closed anastomosis, xiaozhiling injection and partial resection of sphincter ani internus.Results　Among 32 patients 28 cases were cured, 4 cases were obviously improved. The effective rate was 100%.Conclusion　Quadruple therapy, including circular rectal mucosal resection and anastomosis with stapler, rectal antetheca closed anastomosis, xiaozhiling injection and partial resection of sphincter ani internus has remarkable therapeutic effect in curing rectal evacuation disorder type constipation caused by moderate and severe degree rectocele and rectal internal mucosal intussusception, with fewer complications, simple operation, little pain, quick recovery and minimally damage.]]> 2018/8/27 8:16:11 LI Qi-han,LI Qi-wei 557true ［Abstract］　Objective　To explore the effects of middle ear pressure transformation therapeutics for child′s secretory otitis media. Methods　The effects of 37 children (70 ears) of secretory otitis media treated by the middle ear pressure transformation therapeutics were compared with those of 36 children (70 ears) of secretory otitis media treated by Valsalva in the same period. Results　Treatment group: 61 ears with marked effect, 3 ears with effect, 6 ears no effect. Effective rate was 91.43%. Control group: 35 ears with marked effect, 8 ears with effect, and 27 ears no effect. Effective rate was 61.4%. Without untoward effect, treatment group′s healing efficacy apparently was higher than control group′s (P<0.001). Conclusion　The middle ear pressure transformation therapeutics can significantly reduce the children middle ear′s negative pressure and improve hearing. It is safe, convenient and recommendable operation in clinical application.]]> 2018/8/27 8:16:11 LI Dong-yun,ZHU Qiu-mei,LU Qiu-tian,et al. 556true ［Abstract］　Objective　To investigate the therapeutic modality and prognosis of nasal NK/T-cell lymphoma.Methods　Data from 68 cases of nasal NK/T-cell lymphoma in our Hospital was retrospectively reviewed, of which 45 were male cases, 23 were female cases and the median age was 46 years. Of these patients, 32 received radiotherapy alone, 7 chemotherapy alone and 29 chemo-radiotherapy. Radiotherapy alone adopted linear acceler-ator 6MV X-ray or electronic ray or CO-60 radiation. Radiation field of patients in stage IE adopted “L” field, “凸” field or preauricular field and ethmoid field. Lymph node of neck didn′t adopt preventive radiation. Patients in stage Ⅱ adopted faciocervical joint field and lower cervical tangential field with or without ethmoid electronic linear field when tumors intruded the neck. The median radiotherapy dose is 50 Gy. Chemotherapy adopted CHOP project with 4～8 courses of treatment.Results　Local affection of 30 cases of the group of radiotherapy alone completely remitted, the CR rate was 87.5% and the 5-year overall survival(OS) rate was 68.75%. The CR rate of the group of chemotherapy alone was 14.3%, and the 5-year OS was 14.3%. The CR rate and the 5-year OS of the patients received chemotherapy first and radiotherapy second in the group of chemo-radiotherapy were 65.2% and 60.9%, while radiotherapy first and chemotherapy second were 83.3% and 66.7%. The CR rate of the patients in stage Ⅰ was 78.2%, and the 5-year OS was 65.5%; the CR rate of the patients in stage Ⅱ was 60% and the 5-year OS was 50%. The 5-ye-ar OS of the patients in stage Ⅲ/Ⅳ wasn′t got. Conclusion　Therapeutic effect of radiotherapy is obviously superior to chemotherapy for nasal NK/T-cell lymphoma. Nasal NK/T- cell lymphoma is sensitive to radiotherapy while relatively fast to chemotherapy. Patients of nasal NK/T-cell lymphoma in early stage should adopt radiotherapy or general treatment with radiotherapy as primary treatment. Patients in late stage will get bad prognosis with late staging as the independent prognostic factors.]]> 2018/8/27 8:16:11 ZHANG Qun-gui 555true ［Abstract］　Objective　To observe the therapentic effect of bronchial artery embolization combined with reptilase perfusion and pituitrin combined with reptilase in treating pulmonary tuberculosis with massive hemoptysis.Methods　Sixty-eight pulmonary tuberculosis patients with massive hemoptysis were randomly divided into control group and treatment group. The control group was treated by pituitrin plus reptilase; the treatment group was treated with bronchial artery embolization combined with reptilase perfusion. Comparison of hemoptysis were observed.Results　The marked effective rate was 64.7% in the treatment group, that was 20.6% in the control group; total effective rate was 88.2% in treatment group; that was 58.8% in control group, the difference was statistical significant (χ²=7.556, P=0.006).The incidence of adverse reactions in control group was significantly higher than that in the treatment group, the difference was significant (χ²=11.103, P=0. 001).Conclusion　The effect of bronchial artery embolization combined with reptilase perfusion was better than that in pituitrin and reptilase in the treatment of pulmonary tuberculosis with massive hemoptysis.]]> 2018/8/27 8:16:11 GAO Hong-sheng,HE Guang-hui 554true ［Abstract］　Objective　To explore the therapeutic effect and complication of percutaneous coronary intervention in patients with coronary artery disease over 75 years old. Methods　One hundred and twenty-two patients underwent PCI from January 2009 to June 2010 were divided into the elderly group (age≥75 years) and the younger group (60 < age < 75 years). The angiographic characteristics and the incidence of major adverse events such as ventricular fibrillation, angina pectoris during following up were analyzed and compared between the two groups. Results　There were 48 patients in the elderly group and 74 patients in the younger group. The rates of hypertension, diabetes, hyperlipoidemia in elderly group were much higher than those in younger group (P<0.01). The elderly patients were more likely to have multi-vessels lesions and complex lesions (P<0.01). There was no significant statistic difference in the achievement rate of immediate treatment between the elderly group(95.8%) and the younger group(98.6%) (P>0.05). And the in-hospital outcomes and 30 days follow-up revealed the incidence of major adverse events were higher in the elderly group (12.50%) than those in the younger group (5.4%), but the difference between those two groups is not significant (P>0.05). Conclusion　The patients with coronary artery disease over 75 years old are more commonly accompanied by multi-organic dysfunction, their coronary arteries tend to have multi-vessel lesions and complex lesions. The incidence of major adverse events during PCI is higher in the elderly patients. But complications are healed after active treatment, the prognosis is good. PCI treatment is indispensable important means in elderly patients with coronary artery disease.]]> 2018/8/27 8:16:11 WU Yin-xiong, WU Guang-wei, QIN Shao-ming, et al. 553true ［Abstract］　Objective　To explore the value of laparoscopy conservative treatment for the patients of tubal pregnancy with fertility requirement.Methods　The data of 400 tubal pregnancy patients with fertility requirement were retrospectively analyzed who received conservactive surgical management. Laparoscopy was performed in 200 patients, laparotomy in 200 patients.Results　The operation time, bleeding loss and tubal patency rate were compared betwen two groups.The operation time in laparoscopy group was (43.91±15.56) min, and (69.28±18.37) min in laparotomy group. There was no statistical significant difference. The bleeding loss in the laparoscopy group was (40.28±10.26) ml, and (70.69±18.41) ml in laparotomy group. The tubal patency rate of laparoscopy was 90%,and that of laparotomy group was 75%. The difference of bleeding loss and tubal patency rate between two groups was statistically significant（P<0.05）.Conclusion　Laparoscopy conservative surgical management for tubal pregnancy is valuable, especially for the patients with fertility requirement.]]> 2018/8/27 8:24:30 HUANG Ju-ying, LI Ling-yun, SU Yan, et al. 552true ［Abstract］　Objective　To evaluate the clinical efficacy of patients with chronic pelvic inflammation treated with enema with Chinese herbal medicine combined with antibiotics or external application of Chinese herbal medicine combined with antibiotics.Methods　Three hundred and ninety patients with chronic pelvic inflammation were randomly divided into three groups. The 1st treatment group received an enema with Chinese herbal medicine combined with antibiotics; the 2nd treatment group were treated with external application of Chinese herbal medicine combined with antibiotics; the control group were treated with antibiotics singly. The cure rate, total effective rate between three groups were compared by using χ² test.Results　After the end of one course of treatment, the cure rate of 1st treatment group, 2nd treatment group and control group were 43.85%, 40.77% and 26.92%, and the total effective rate was 82.31 %, 77.69% and 60.77%, respectively; After the end of two course of treatment, the cure rate of 1st treatment group, 2nd treatment group and control group was 66.15%, 64.62% and 47.69%, the total effective rate was 94.62%, 93.85% and 79.23%, respectively. Compared with the control group, the cure rate and total effective rate of 1st treatment group and 2nd treatment group were significantly higher after 1 to 2 courses of treatment (P<0.05 or P<0.01).Conclusion　The comprehensive therapy of enema with Chinese herbal medicine combined with antibiotics or external application of Chinese herbal medicine combined with antibiotics has significant efficacy in the treatment of patients with chronic pelvic inflammation and deserves to be promoted in clinical application.]]> 2018/8/27 8:24:30 WEI Feng-jin 551true ［Abstract］　Objective　To investigate the incidence of urinary tract stones and hydronephrosis in children fed with infant formula milk power contaminated with melamine, and evaluate the influences of melamine on children urinary system. Methods　Totally 8 579 children fed with infant formula milk powder were screened for urinary stone using B-ultrasound method in the people′s hospital of Guangxi zhuang autonomous region from September to October 2008. Urine routing examination and serum BUN/Cr were conducted on those Ultrasound-positive cases. Results　Ultrasound examination showed 274 positive cases, including 173 cases of urinary calculi, 53 cases of hydronephrosis, 49 cases of renal pelvis separation, 17 cases of renal cysts. Five cases of severe hydronephrosis were hospitalized, 1 of which occurring renal failure. All these 5 patients were cured and discharged finally. Conclusion　This study found that melamine easily forms sand-like urinary calculi in infants and young children. The obstruction of ureteropelvic junction could cause hydronephrosis, and in severe cases, affect kidney function. Hydration therapy could promote the stone discharging. Serious cases of obstruction may need surgical intervention to relieve the long-term damage of renal function. Early diagnosis and treatment is the key to prognosis. Ultrasound follow-up should be suggested to positive cases to monitor hydronephrosis.]]> 2018/8/27 8:24:30 HONG Mei, ZHEN Hong, WEI Ling-hua 550true ［Abstract］　Objective　To establish a suitable set for verifying the three dimensional conformal radiotherapy plan system (TPS) by our existing condition. Methods　Using gather- benzene-board a model was manufactured, according to the three dimensional directional localizations′ requests, the CT scanning was carried on, and the images were inputted into the TPS; the radiotherapy plans were worked out, then the total actual absorbed dose in all fields at ISOcenter point in all kinds of plans under therapy machine was measured, and it was compared with the prearranged dose total values of the plans′ results, and the conformity of the target center coordinate about plan results with the coordinate of ISOcenter of machine under the simulating machine′s conditions was compared. Results　After the actual measured percent depth dose(PDD) data of the machine and so on were inputted to the TPS, the actual measured dose of the target area was basically with consistent the prearranged does of the threatment plan, the error was less 0.7 percent. The error between the center point localization of target area in the plan and the machine ISOcenter was less 1.5 mm. Conclusion　The TPS can be used for designing in the radiotherapy. Before the TPS operation, it should be supposed to input the actual measured data, and the relevant tests for the worked plans from the TPS should be carried on, in order to determine whether it could be used clinically.]]> 2018/8/27 8:24:30 CHEN Yu-biao,YANG Qiu-quan, PAN Su-ming, et al. 549true ［Abstract］　Objective　To analyse the changes of carotid atherosclerosis, D-dimer and homocysteine in patients with asymptomatic cerebral infarction (ACI) and find the relationship of ACI with above indexes.Methods　In 50 patients with ACI(ACI group),50 patients with symptom cerebral infarction (CI group) and 50 normal people (normal group) the examination of carotid color Doppler ultrasound,D-dimer,and homocysteine were performed.Results　The levels of Carotid atherosclerosis, D-dimer and homocysteine in CI group was significantly higher than those in ACI group (P<0.01). The levels of above indexes in ACI and CI groups were higher than those in the normal group (P<0.01). The correlation analysis showed, there was a positive correlation between homocysteine and D-dimer in ACI group (r=0.598, P<0.01）; there was a positive correlation between homocysteine and D-dimer in CI group（r=0.605, P<0.01）; there was a positive correlation between homocysteine and D-dimer in normal group （r=0.631, P<0.01）. The examination results of homocysteine and D-dimer in different plaque types in three groups showed, there were statistically significant intragroup and intergroup differences (P<0.01).Conclusion　Carotid atherosclerosis, D-dimer and homocysteine are the risk factor for ACI; and unstable plaque is closely related with D-dimer and homocysteine; the three factors play an important role in the occurrence of cerebral infarction.]]> 2018/8/31 16:02:31 XU Qing-dong, HE Guang-hui,SONG Lei,et al. 548true ［Abstract］　Objective　To examine the risk factors and characteristics about hypertension(HP) in patients with impaired glucose tolerance(IGT).Methods　Five hundred and eighty-six patients with IGT were found by A cross-sectional study were analyzed. The risk factors and characteristics of HP in patients with IGT.Results　The prevalence of HP in patients with IGT was 36%,it was lower in male(34.92%) than in female(36.83%)（P>0.05）.Regression analysis revealed that the family history of HP,waist circumference,total cholesterol and fasting plasma glucose were risk factors of HP in patients with IGT.Conclusion　The prevalence of HP in patients with IGT was 36%,the main risk factors that can be controlled are centricity obesity, disorder of blood glucose and lipid metabolism.]]> 2018/8/31 16:02:31 PANG Jin-cai,FENG Shu-hua，PENG Jing 547true ［Abstract］　Objective　To compare anesthetic effect and adverse effects of three kinds of compatible methods patient-controlled intravenous analgesia (PCIA) affter upper extremity orthopedic surgery.Methods　One hundred and twenty cases of ASA Ⅰ～Ⅱ grade undergoing upper limb orthopedic surgery with open reduction and internal fixation were randomly divided into three groups of 40 cases: A group of fentanyl 0.015 mg/kg;B group of fentanyl 0.015 mg/kg plus ketamine 2.0 mg/kg;C group of fentanyl 0.015 mg/kg plus flurbiprofen ester 100 mg. Normal saline in each group were added to 100 ml. The continuous infusion was performecl at 2 ml/h. At 6,12,24,48 h after operation VAS score, sedation score (SS), and the incidence of adverse reactions were recorded.Results　At 6,12,24,48 h after operation VAS score of B, C group less than the that of A group, the difference was statistically significant (P<0.05); At 6,12,24,48 h after operation SS of A group was slightly higher than the those of B, C group,but the difference was not statistically significant(P> 0.05). The incidence of complications such as nausea and vomiting of A group was significantly higher than those of the other two groups. The difference was statistically significant(P<0.05).Conclusion　Small dose of fentanyl adding a small amount of ketamine or a small amount of flurbiprofen ester for PCIA after upper extremity orthopedic surgery have better effects and less postoperative complications.]]> 2018/8/31 16:02:31 MENG Yuan-jing,MO Li,ZENG Qiong-zhen,et al. 546true ［Abstract］　Objective　To observe the levels of serum high-sensitivity C-reactive protein (HsCRP) in patients with asthma at acute stage and to investigate its clinical significance. Methods　Totally 72 patients with asthma at acute stage（treated group） and 31 healthy volunteers(control group) were included in this study. HsCRP in the patients was measured before and after treatment,and HsCRP in control group was also measured. At the same time,blood routine and pulmonary function were examinated. Results　HsCRP levels of the patients before treatment was significantly higher than that of controls(P<0.01). After treatment, HsCRP levels of the patients was significantly lower(P<0.01), being still significantly higher than that of control group (P<0.05). Conclusion　HsCRP levels can be used as an inflammatory index for evaluation of patient′s condition.]]> 2018/8/31 16:02:31 LIANG Hui-jun 545true ［Abstract］　Objective　To evaluate the clinical efficacy of BiPAP non-invasive mechanical ventilation in the treatment of patients with severe asthma. Methods　Sixty-nine patients with severe asthma were divided into the observation group (35 patients) and control group (34 patients). The control group were give routine treatment, the observation group were treated with BiPAP ventilation in addition to the routine treatment. The changes of clinical symptoms and arterial blood gas (PaCO₂, PaO₂ and SaO₂) before and 3 days after the treatment were compared. Results　The observation group showed significantly improvement in PaCO₂, PaO₂ and SaO₂ and need tracheal intubation cases and clinical situation compared with control group (P<0.05). Conclusion　Using non-invasive ventilation based on routine treatment can improved the clinical manifestation, which is efficient, safe and less painful.]]> 2018/7/16 16:35:42 XU Jun-xu 544true ［Abstract］　Objective　To investigate the best cervical cancer screening method in the urban population in Nanning from the view of economics. Methods　During 2006～2009, many women came to Nanning Maternity & Child Healthcare Hospital for screening cervical cancer. Most of them were organized by Trade-Union units or by neighborhood committee of the communities. There were five screening methods induding TCT + HPV, TCT, Cervical smears + HPV, Cervical smears and VIA + VILI. Those showing abnormalities needed to apply for further colposcopy and biopsy, for example cytology ≥ASCUS, VIA or VILI was positive. Pathologic-section diagnosis was the golden criterion, by comparing and analyzing the number of groups of screening examination. Results　There were 506 groups of women aged 25～59(12507 people in total) to be screened for cervical cancer. Each screening examination group number was 43, 59, 60, 182, 162 respectively; the positive rate of each screening way was 10.32%, 9.52%, 5.48%, 2.69% and 4.48% respectively. Conclusion　From the view of economics, VIA + VILI is the best screening method for cervical cancer in the urban population in Nanning.]]> 2018/7/16 16:35:42 YANG Mei 543true ［Abstract］　Objective　To explore the clinical effect of part-cholecystetomy in the treatment of disease of gallbladder. Methods　The data of 62 patients undergoing part-cholecystetomy from September 1998 to November 2009 were collected and analyzed retrospectively. Results　All of the 62 patients were healed. Incision infection occurred in 9 patients, postoperative leakage of bile occurred in 3 patients, pulmonary infection occurred in 7 patients. The average time of hospitalization was 17 days (range 9～31 days). Follow - up lasted three months to three years. Their symptoms had no recurrence. All patients got satisfying effect. Conclusion　While there are difficulties in cholecystectomy, part-cholecystetomy is a simple safe and feasible method. It not only can achieve the purpose of cholecystectomy, but also can reduce the injuries of extrahepatic bile duct and blood vessel. We must strictly master the indication and manage residue of cystic duct correctly.]]> 2018/7/16 16:35:42 FENG De-liang 542true ［Abstract］　Objective　To study the pathogens and their drug sensitivities of early-onset neonatal septicemia and late-onset neonatal septicemia, to direct the clinical usage of antibiotics and reduce the produce of drug-resistant bacteria. Methods　A retrospective analysis was conducted on 48 cases of neonatal septicemia with positive blood culture who were admitted to the neonatal section of our hospital. The study was carried out to analyze the blood culture results and their drug sensitivities. The cases were assigned into two categories, early-onset neonatal septicemia and late-onset neonatal septicemia according to the time of onset of septicemia. Results　Early-onset neonatal septicemia mainly happened in premature neonates,while late-onset neonatal septicemia mainly happened in full term neonates. The bacteria in the early-onset neonatal septicemia group were mainly gram-negative bacillus (escherichia coli, klebsiella pneumoniae, and so on）, and the pathogens in the late-onset neonatal septicemia group primarily consisted of gram-positive bacillus. Between the early-onset neonatal septicemia group and the late-onset neonatal septicemia group, there were significant statistical differences in gestational age and pathogens (P<0.05). The pathogens were highly sensitive to vancomycin, meropenem, levofloxacin, tienam. Conclusion　The reasonable choice of antibiotics in treatment of neonatal septicemia should be based on the disease, pathogenic bacteria and results of drug susceptibility. It can reduce the growth of drug-resistant bacteria and improve clinical treatment effects.]]> 2018/7/16 16:35:42 MENG Dan-hua,WEI Qiu-fen 541true ［Abstract］　Objective　To explore the effect of comprehensive rehahilitation therapy (famale hormone, anti-depression medicines, Chinese medicines and psychological interference) in the treatment of peri-menopausal women with severe depression. Methods　Twenty-six peri-menopausal women with severe depression were treated with nilestriol, fluoxetine, Jieyu decoction and psychotherapy. All patients were evaluated by HAMD, SDS score before and after treatment. Serum E2,FSH were tested at the same time. Results　After 8 weeks of comprehensive rehabilitation therapy, serum E2 levels significantly increased, serum FSH levels significantly decreased. HAMD scores and SDS scores were decreased significantly (P<0.01). The results showed that 61.5% (16/26) of patients were cured, the excellent rate and effective rate were 23.1% (6/26) and 15.4% (4/26) respectively. Conclusion　It is suggested that comprehensive rehabilitation therapy is a safe and effective therapeutic method with less side effect in treating peri-menopausal women with severe depression.]]> 2018/7/16 16:35:42 LUO Hong-ling, LI Xue 540true ［Abstract］　Objective　To investigate the concentrations and clinical significance of secretory leukocyte protease inhibitor (SLPI) in pleural effusions with various etiologies. Methods　Pleural effusion samples were obtained from 85 patients who presented to the respiratory institute (29 with tuberculous pleural effusion, 30 with malignant pleural effusion, 15 with bacterial pleural effusion and 11 with transudative pleural effusion). The pleural effusion and serum levels of SLPI were determined by sandwich enzyme-linked immunosorbent assays (ELISA). Results　（1）In pleural effusion, the concentrations of SLPI in tuberculous pleural effusion (21 1710±29 130)pg/ml was significantly higher than that in malignant group (99 274±21 807)pg/ml, in bacterial group (127 980±34 299)pg/ml and in transudative group (109 360±21 619)pg/ml (P<0. 05). But there were no statistical significance among the malignant group, bacterial group and transudative group (P>0. 05). （2）In serum, the tuberculous group (35 116±4 122. 1)pg/ml and malignant group (25 767±2 054)pg/ml were higher that in transudative group (5 1377±10 190)pg/ml (P<0. 05). There was no difference between bacterial group (52 396±8 954. 5)pg/ml and transudative group (P>0. 05), there were also no statistical significance among the tuberculous group, malignant group and bacterial group (P>0. 05). （3）Between pleural effusion and serum, there were statistical significance in tuberculous group, malignant group and transudative group (P<0. 05), but not in bacterial group(P>0. 05). （4）The pleural levels of SLPI was no correlated with the corresponding serum levels (P>0. 05). （5）The cut-off value of pleural SLPI for the diagnosis of tuberculous pleural effusion was 236071pg/mL with the corresponding sensitivity and specificity 0. 433 and 0. 968, respectively. Conclusion　Pleural SLPI may be helpful for the differential diagnosis of tuberculous pleural effusion and the other pleural effusion, and the detection of pleural SLPI could be a new tool to diagnose tuberculous pleural effusion.]]> 2018/7/16 16:36:19 WU Cong，FENG Ting-mei，WU Yan-bin 539true ［Abstract］　Objective　To explore the comparability between ABBOTTi2000 automatic luminometer and immune i-CHROMA Reader immunofluorescence analyzer in the detection of total prostate specific antigen(TSPA). Methods　Immunofluorescence dry chemical chromatography method was used for quantitative detection of TPSA in ovder to evaluate the performance, including intra-repeatability, linearity, accuracy. Results　Determination of high-repetition, low-value samples, CV<10%; the linear regression equation Y=0. 9748X+0. 048; and Chemiluminescence immunoassay analysis, r=0. 984. Conclusion　Immunofluorescence dry chemical chromatography quantitative detection systems and ABBTTi2000 automatic chemiluminescent instrument has good repeatability, linearity and methodology correlation and is very suitable for clinical laboratories and small-volume samples of outpatient and emergency use.]]> 2018/7/16 16:36:19 ZHANG Jin-li,HUANG Jun,LIU Xiao-chun,et al. 538true ［Abstract］　Objective　To study the application of combined TCT with HPV testing in screening of cervical intraepithelial lesions. Methods　In women who received the combined TCT with HPV testing in gynecology clinic in our hospital, 121 women with alone TCT positive were used as TCT group；169 women with alone HPV positive as the HPV group, 92 women with both TCT and HPV positive as the combined TCT with HPV group. Three groups were confirmed by colposcopic biopsy, and the histopathology was used as the gold standard. The results of pathological diagnosis were compared with the results of three testing. The positive results of three testing in cervical intraepithelial lesions were compared. Results　The positive predictive value in TCT group, HPV group and the combined TCT with HPV group were 57. 02% and 30. 77%, 75. 00% respectively. There was significant difference between the combined TCT with HPV group and TCT group (χ² = 7. 40, P<0. 05)；and between the combined TCT with HPV and HPV group (χ² = 46. 87, P<0. 05). Conclusion　The TCT combined with HPV screening test is superior to alone TCT and HPV testing in screening of cervical intraepithelial lesions and is the ideal method for screening of cervical cancer and precancerous lesions.]]> 2018/7/16 16:36:20 LIN Yue-qin, ZHANG Lin 537true ［Abstract］　Objective　To investigate the effects of functional recovery of early intervention of horizontal power bicycle and electric standing bed in the treatment of patients with hemiplegia after acute stroke. Methods　Fifty-nine patients with hemiplegia after acute stroke were randomly divided into two groups. The control group (n=29) were treated by conventional medicine, acupuncture and rehabilitation training; on the basis of above treatment of control group, the treatment group (n=30) were treated by using horizontal power bicycle and electric standing training with electric power standing. The treatment time was 4 weeks. The balance function, motor function and ADL in two groups were compared before and after treatment. Results　After treatment, balance function, motor function and ADL points significantly improved in two groups (P<0. 05 or P<0. 01). The effects of treatment group were significantly better than those of the control group (P<0. 05). Conclusion　The therapeutic effects of early intervention of horizontal power bicycle and training with electric power standing bed in the tretment of patients with hemiplegia after acute stroke is better compared with that of the control group.]]> 2018/7/16 16:36:20 PAN Su-lan, DENG Qiu-lan, ZHANG Cong 536true ［Abstract］　Objective　To explore the clinical effects of controlled-release dinoprostone suppository in cervical ripening. Methods　A randomized control study was performed in 160 primiparas of vaginal delivery without taboo, full-term pregnancy, cervical Bishop score of 6 or less. Experimental group (n=60) received controlled-release dinoprostone suppository, while control group (n=100) received intravenous drip of low dose oxytocin voluntarily. Then artificial labor success rate with vaginal delivery were compared. Results　After administration, production rate, 24 h vaginal delivery parturition rate in the experimental group were 98. 33% and 76. 66% respectively, and those in the control group were 85. 00%, 10. 00%, there was significant difference between the experimental group and control group(P<0. 05), while no significant differences were found in caesarean birth, postpartum hemorrhage, injuries of the soft birth canal, Neonatal asphyxia rate between the two groups（P>0. 05）. The chief side effect of controlled-released dinoprostone was titanic contraction of uterine. Two cases in experimental group had the chief side effect, and recovered after discontinuation. Conclusion　Controlled-release dinoprostone suppository is more effective, convenient and safe than oxytoncin for cervical ripening and induced delivery, and no adverse effects on mother and child.]]> 2018/7/16 16:36:20 ZHANG Dong-mei, LIN Hong, ZHOU Ni 535true ［Abstract］　Objective　To evaluate the clinical effect of danhong injection（DHI） and its influence on the concentration level of the plasma NPY and hs-CRP in the treatment of the patients with congestive heart failure(CHF). Methods　Seventy-five patients were randomly divided into treatment group and control group. Both were given oxygen uptake, cardiotonic agents, diuresis, the dilation of blood vessels, anti-infection, symptomatic treatment, meanwhile, the treatment group were also given DHI, one per day, for 2 weeks. The concentration level of NPY and hs-CRP were determined before the entry into the trial and after two weeks of the trial, respectively. Results　After 2 weeks, the concentration level of NPY and hs-CRP in two groups were significantly lower than that before treatment (P<0. 05). However, the concentration level of NPY and hs-CRP in treatment group were significantlv lower than those in control group(P<0. 05). Conclusion　DHI interventions can decrease the level of the NPY and hs-CRP significantly in patients with CHF and plays an important role in improving cardiact funtion of the patients.]]> 2018/7/16 16:36:20 YE Shi-tao，CHEN Dou，XU Fei-cui 534true ［Abstract］　Objective　To study the effect of soluble fms-like tyrosine kinase-1(sFlt-1) on preeclampsia.Methods　The level of sFlt-1 in 70 patients with preedclampsia was measured by enzyme linked immunosorbent assay and compared with control group.Results　The level of sFlt-1 was higher and the weight of neonate was lower in patients with preedclampsia than that in control group. No significant differences was found in 1 minute Apgar Score between two groups. A negative linear correlation between the level of sFlt-1 and the weight of neonate was found( r=-0.69; P<0.01).Conclusion　The increase of sFlt-1 in patients with preeclampsia can activate and damage endothelial cells which has a harmful effect on fetus.]]> 2018/7/16 16:37:43 LIANG Li-li,CAI Chun-fang,WAN Bo,et al. 533true ［Abstract］　Objective　To explore the velue of clinical application of fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) in AECOPD patients with mechanical ventilation.Methods　Sixty-six patients with mechanical ventilation were randomly divided into control group (n=33) and treatment group (n=33). All patients accepted anti-infection, nutritional support treatments. The patients in the treatment group were treated with BAL, others in the control group accepted routine treatment. The therapeutic effects in the two groups were evaluated and compared.Results　The treatment effects in treatment group was better than that in control group(P<0.05). The improvement of blood gas analysis in treatment group was better than in control groups (P<0.05), the time of pulmonary infection control window, the time of mechanical ventilation, length of stay in treatment group were shorter than those in the control groups (P<0.05 or P<0.01), the number of success to remove ventilator, organs failure and hospital mortality in treatment group were less than those in the control group (P<0.05).Conclusion　Fiberoptic bronchoscopy with BAL treatment could be safe and effective for AECOPD patients with mechanical ventilation.]]> 2018/7/16 16:37:43 LIAO Ou-fei, LIN Song, WU Hua-ping, et al. 532true ［Abstract］　Objective　To highlight the advantages of proseal laryngeal mask airway (PLMA) in the anesthesia for cervical spine fracture surgery by comparing the success rates and hemodynamic changes between groups of patients inserted with laryngeal mask and endotracheal intubation respectively.Methods　Sixty ASA status I-Ⅲ patients with cervical spine fracture requiring surgery were randomly divided into two groups: PLMA group (Group A) and blind endotracheal intubation group (Group B). After regular anesthesia induction, tracheal catheter and PLMA (hereinafter collectively called anesthesia components) were placed respectively. SBP, DBP and HR value before and after induction, at 1 min and 3 min after placing components, 5 min before and after removing components were recorded as well as the time required for placing the components, success rates and complications.Results　There were significant differences in BP at 1 min and 3 min after successfully placing the components, and in BP and HR before and after removing the components for between groups (P<0.05); The values of Group B were higher than those of Group A; as for the time required for placing the components and anesthesia complications such as hypoxemia, irritating cough, bronchospasm, hemorrhage and hematoma, Group B was also significantly higher than Group A.Conclusion　Adopting proseal laryngeal mask airway (PLMA) in anesthesia were a breath supporting method with easy operation, safety and rapidness, few postoperative respiratory complications, which is especially applicable for patients who are difficult for intubation because of cervical spine fracture etc.]]> 2018/7/16 16:37:43 TANG Xiao-qi, HUANG Yan-hua 531true ［Abstract］　Objective　To investigate the relationship between carotid atherosclerotic plaques and acute myocardial infarction (AMI).Methods　30 patients with AMI(observation group) and 28 patients without AMI(control group) underwent carotid sonography and the atherosclerotic plaques were classified into stable and unstable plaques. The incidence rate of plaque was calculated and compared statistically.Results　The incidence rate of plaque in observation group was significantly higher than that in control group (P<0.05). The incidence of unstable plaque was statistical different between the two groups (P<0.05).Conclusion　The presence of carotid atherosclerotic plaques is related with the coronary artery disease. The unstable plaque on carotid sonography correlates with myocardial infarction.]]> 2018/7/31 15:05:07 PENG Xin-hui 530true ［Abstract］　Objective　To explore the related factors of avascular necrosis of femoral head (AVNFH) after surgical treatment of developmental dislocation of the hip(DDH).Methods　The clinical data of 132 patients(including 137 hips)with DDH treated by various surgical methods from January 1998 to October 2010 were retrospectively analyzed. After surgical treatment, AVNFH were found in 29 patients(including 32 hips).Results　After surgical treatment,106 patients(including 118 hips) with DDH were followed up for 38 months on average.According to the Salter evaluation standard, 29 patients (including 32 hips) were complicated by AVNFH after surgical treatment.The incidence of AVNFH was 27.1%.Conclusion　Surgical treatment can not completely avoid the occurrence of AVNFH. The occurrence of AVNFH after surgical treatment is closely related to many factors such as surgical intervention, patients′ age, the degree of head dislocation and so on.]]> 2018/7/31 15:05:07 LI Deng, LIANG Ye 529true ［Abstract］　Objective　To explore the therapeutic effect of simvastatin combined with nimodipine in the treatment of subarachnoid hemorrhage (SAH).Methods　Ninety-six patients with SAH were randomly divided into the treatment group and the control group.Patients in the control group were treated with routine therapy, and patients in the treatment group were given simvastatin combined with nimodipine on the basis of routine therapy. The scores of neurological impairment,the incidence of cerebral vasospasm, the incidence of hydrocephalus, the incidence of rebleeding and mortality rate between the two groups were compared.Results　Neurological impairment scores, the incidence of cerebral vasospasm, the incidence of hydrocephalus and mortality rate in the treatment group were significantly lower than those in control group (P<0.05), but the incidence of rebleeding showed no statisical significance between two groups (P>0.05).Conclusion　Simvastatin combined with nimodipine can evidently improve the neurological function in patients with SAH, and reduce the incidence of cerebrel vasospasm,and hydrocephalus,and mortality rate after SAH.]]> 2018/7/31 15:05:07 LUO Qing- yan 528true ［Abstract］　Objective　To observe the security and efficacy of intravenous thrombolytic therapy on acute myocardial infarction(AMT).Methods　Ninety-three patients with AMI were treated by intravenous thmmbolytie therapy of streptokinase under electrocardiogram monitoring and their results were analyzed.Results　The coronary rceanalization were observed in 69 cases，with a recanalization rates of 74.19% and no recanalization was found in 24 cases. Of them 3 patients dided, with a mortality rate of 3.23%. The rates of recanalization of thrombolytic therapy in <6 h of onset group were significantly different higher than those in 6～12 h of onset group(P< 0.05).Conclusion　Early intravenous thrombolytic therapy to AMI can decrease the complication and mortality rate, increase the recanalization rates.]]> 2018/7/31 15:05:07 CHEN Chun-xiao, LI Pei-kan 527true ［Abstract］　Objective　To enhance the level of the diagnosis and management for patients with acute pulmonary embolism. Methods　The clinical manifestations, ancillary examination restults, treatment methods and prognosis of 31 patients with acute pulmonary embolism treated in our hospital from February 2007 to September 2010 were restrospectively analyzed. Results　All patients received anticoagnlant treatment. Of them 20 patients were cured and 11 patients died. Of them 9 patients died of cardiac arrest after effort rescue. Conclusion　Acute pulmonary embolism is a severe acute disease and earlier diagnosis and treatment may improve survived rate and prognosis of patients.]]> 2018/7/31 15:05:07 DUAN-Hao,DAI Guo-fang,QI Ya-ping 526true ［Abstract］　Objective　To study the infection status of mycoplasma and the druy sensitivity in patients with bacteirial vaginosis.Methods　The Mycoplasma ISE Test Kit was adopted to perform mycoplasma culture，ideniification and drug sensitivity test in 595 patients with BV.Results　Ureaplasma urealyticum (Uu) was 45.6% and the mixed Uu and mycoplasma hominis(Mh) was 6.3% in the detection of 595 patients with BV. Sensitivity drug were josamycin,doxycycline,tetracycline, minocycline,clarithromycin and azithromycin.Conclusion　The infection rate of mycoplasma in patient with BV is 51.9%; the major is Uu; Mh influenced on drug sensitivity obviously; josamycin has the highest senstivity for mycoplasma infection. Clinical treatment and control mycoplasma infection should base on the differences of infection type and drugs sensitivity to select antibiotic.]]> 2018/7/31 15:05:07 QIN Nai-hui,PEI Zheng-ling,QIN Gui-fang,et al. 525true ［Abstract］　Objective　To analyze the changes of serum C-reactive protein and serum ionized calcium levels in the patients with acute cerebral vascular disease and to study their effects on the treatment and prognosis.Methods　The data of the diagnosis and treatment in the 88 patients with acute cerebral vascular disease from January 2005 to July 2010 were analyzed and summarized retrospectively.Results　The first hospitalized day,in 88 patients the levels of hs-CRP were significantly higher than normal level, and serum ionized calcium levels were decreased with different rate of decline. When the changes of C-reactive protein and serum ionized calcium levels were greater and longer lastingly,the condition of patients with acute cerebral vascular disease were more severe and worse prognosis.Conclusion　It is positive of clinical significance for determining treatment and valuing prognosis of acute cerebral vascular disease through observing generally the changes of C-reactive protein and serum ionized calcium levels.]]> 2018/8/1 8:23:53 LONG Fei-hua,LI Heng，CHU Hao-xiang 524true ［Abstract］　Objective　To observe the therapeutic effect end adverse reactions of long li run zao capsule in the treatment of neuro psychiatric disorder patiens with hyperactivity of fire due to yin deficiency.Methods　A total of 120 neuro psychiatric disorder patients hyperactivity of fire due to yin deficiency were randomly divided into two groups. The control group received general medical treatment; besides the general medical treatment, the study group was trented with Long li run zao capsule.Before the treatment and at the end of 1,2,4,6 week after of treatment BPRS,HAMA and TESS were used for assessing the efficacy and safety.Results　There were significant differences (P<0.05) in effect between the two groups. The improvements of irritability and constipation in the study group were much more than those in the control group (P< 0.01), moreover the frequency of the adverse reactions of the study group was lower and its degree was milder than the control group.Conclusion　Long li run zao capsule has certain effects in the treatment of neuropsychiatric disorder patients with hyperactivity of fire due to yin deficiency, it could improve the irritability, constipation, and other major symptoms of these patients, reduce the dosage and the side-effect of psychotropic drugs, moreover has good security.]]> 2018/8/1 8:23:53 HUANG Ying-min, WEN Yi-xiong, LIANG Xu-ri，et al. 523true ［Abstract］　Objective　To investignte the clinical curative effects of atomization inhalation budesonide and salbtamol in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD).Methods　Eighty patients with diagnosed AECOPD were randomly divided into the treatment group and control group，with 40 patients in each group. On the basis of conrentional treatment such as anti-infection, relieving cough and reducing phlegm，etc，the treatment group was treated by atomization inhalation of budesonide suspension and salbtamol solution in saline，twice a day，for 7 days； while the control group was treated by atomization inhalation of salbutamol solution in saline，twice a day, for 7 days and the improving conditions of lung function and clinical symptoms were observed.Results　The improvement of lung function and curative effects in the treatment group were superior to those in the control group (all P<0.05).Conclusion　The curative effects of atomization inhalation of budesonide combined with salbutamol in the treatment of patients with AECOPD is superior to that of single salbutamol, and it is worth clinical promating.]]> 2018/8/1 8:23:53 GULi·kadeer, WANG Li-xia, ZHAO Jing, et al. 522true ［Abstract］　Objective　To evaluate the clinical efficacy of the procedure for prolapse and hemorrhoids (PPH) plus multilingual regional skin bridge plastic bypass grafting surgery in the treatment of circumferential mixed hemorrhoids.Methods　The ninety patients with circumferential mixed hemorrhoids were randomly divided into treatment and control group(45 cases, each group). The treatment group was treated by PPH plus multilingual regional skin bridge plastic bypass grafting surgery and control group by external dissection and internal ligation procedure.Results　In comparison between two groups, treatment group was significantly superior to control group in the therapeutic effect,operation time, recovery time, wound healing time, cure rate and postoperative recurrence rate(P<0.05).Conclusion　The method of PPH plus multilingual regional skin bridge plastic bypass grafting surgery is a comparative ideal surgical method to treat circumferential mixed hemorrhoids.]]> 2018/8/1 9:43:06 LI Xue-hua, YU Zhi-tao, WANG Yue-hui,et al. 521true ［Abstract］　Objective　To investigate the clinical efficacy of the interventional chemotherapy in super-selective intracranial artery after the opening blood-brain barrier.Methods　Ninety confirmed lung cancer patients with brain metastases were randomly divided into three groups:mannitol catheter chemotherapy group, catheter chemotherapy group and whole brain radiotherapy group. In the mannitol chemotherapy group,20% mannitol,carboplatin and gemcitabine chemotherapy were respectively infused into the super-selective tumor support arteries with catheter technique with femoral artery.In catheter chemotherapy group, carboplatin and gemcitabine were infused. One month after the treatment the efficacy were compared between three groups according to the efficacy judging criteria. The survival rate between three groups was compared by telephone follow-up survey.Results　The total effective rate of the mannitol catheter chemotherapy group in the improvement of prognosis was 80.00% which was higher than the 50.00% of the catheter chemotherapy and the 16.67% of the whole brain chemotherapy group. There was statistically significant difference between three groups (P<0.05). One -year survival rate, two-year survival rate,and three-year survival rate in mannitol catheter chemotherapy group were 56.67%, 23.33%, 6.67% respectively.The differences between the three groups was statistically significant (P<0.05).There was statistically significant difference in the median survival time between the three groups(P<0.05).Conclusion　Mannitol catheter chemotherapy for brain metastatic tumor of lung cancer after the opening of blood-brain barrieer has advantage of simple operation and less complications.During the treatment,chemical drugs can arrive at the tumor supportive arteries directly and kill the tumor cells rapidly,which was worthy of popularization.]]> 2018/8/1 9:43:06 GAO Hong-sheng,XU Qing-dong,HE Guang-hui 520true ［Abstract］　Objective　To investigate the relationship between different accumulations of risk factor components and levels of glycated haemoglobin(HbA1c) in type2 diabetic patients.Methods　One hundred and fifty-nine diabetic patients from community received epidemiology inquiry, anthropometric profile and blood biochemical tests.Results　（1）In this population, diabetic patients with risk factor were 103(64.8%), and the level of glycated haemoglobin in those with risk factor was higher than in those without risk factor (P<0.01);（2）Binary logistic regression analysis revealed that compared with the group without any risk factor component or with only one component, the OR values of the group with 2 risk factor components, with 3 risk factor components,with 4 risk factor components and with all 5 risk factor components on HbA1c were 1.942(1.063 ～ 3.514), 3.041(2.182 ～ 7.481)、3.900(2.091～ 9.562) and 5.910(3.991～ 10.562) respectively.Conclusion　The study suggested that the accumulations of risk factor components increase the levels of glycated haemoglobin in diabetic patients.]]> 2018/8/1 9:43:06 LI Yong-kun, HUANG Li-yuan,WANG Cui 519true ［Abstract］　Objective　To investigate the methods and indications of common bile duct exploration and lithotomy through cystic duct under choledochoscope. Methods　Sixty-one patients with suspected common bile duct calculi or other exploration indicator were selected. Cystic duct was retained length enough for facilitating following procedure, OLYMPUS-P20 choledochoscope was gently inserted into cystic duct (Cystic duct would be explanted if it was not big enough in diameters). Calculus was pulled out when it was found through choledochoscope. The huge calculus bigger than cystic duct in diameter that made them difficult to pass it would be removed by routine common bile duct exploration procedure. Cystic duct was ligated after injection of 80 000～160 000 units of gentamicin through it at the end of operation. Results　In 29 patients with calculi at the distal of the common bile duct, calculi were removed through cystic duct under choledochoscope in 24 patients, the calculi in other 5 patients was removed by routine common bile duct exploration procedure, no calculus was found in the remain 32 patients. Sixty-one patients recovered well and quickly after operation.No postoperative bile leakage and biliary tract bleeding occurred after operation in all sixty-one patients. Post-operation ultrasonograph and T tube imaging check concerned no retain calculus in common bile ducts. Conclusion　Common bile duct exploration and lithotomy through cystic duct under choledochoscope is a effective technique with less operation trauma, quickly recover and can decrease in-hospital days in patients with suspected common bile duct calculi. At present, it is mainly applied to secondary small calculi in common bile duct with distention cystic duct.]]> 2018/8/1 9:43:06 MA Li-lin, ZHU Jian-wei, LU Li-ping, et al. 518true ［Abstract］　Objective　To evaluate the clinic effects of extraction of mandibular impacted tooth with many roots by minimally invasive extraction instrument and air turbine drill.Methods　One hundred mandibular impacted tooth which were to be exacted were randomly divided into two groups: traditional extraction group and minimally invasive extraction group, 50 for each group. The duration of extraction, subjective assessment during and after operation, limitation of mouth opening after operation and dry socket after operation were assessed.Results　The rates of the minimally invasive extration group were lower significantly than those of the traditional extraction group(P<0.05).Conclusion　Minimally invasive extraction instrument is worthy of clinic use.]]> 2018/8/1 9:43:06 TANG Zeng-bin,CHEN Wei,SHEN Ning 517true ［Abstract］　Objective　To study the influence of the combination of edaravone with early hyperbaric oxygen therapy on serum levels of S-100β, neuro-specific endolase (NSE) and NIHSS score of the patients with acute cerebral infarction (ACI).Methods　One hundred and twenty patients with ACI were randomly divided into two groups. Sixty patients in the controlled group were treated with routine regimen which was composed of inhibiting platelet aggregation, improving brain blood flow and metabolism of brain cells, etc. And 60 patients in the edaravone group were treated with edaravone combined with hyperbaric oxygen on the basis of routine regimen. Serum levels of S-100β and NSE were detected on the 3^rd, 7^th, 14^th day after treatment. Otherwise, curative effect was evaluated with NIHSS score on the 7^th, 14^th, 28^th day after treatment.Results　Serum levels of S-100β and NSE, and NIHSS score in the patients of the edaravone group were obviously lower than those in the patients of controlled group.Conclusion　The combination of edaravone with hyperbaric oxygen therapy can apparently lower serum levels of S-100β，NSE and NIHSS score in patients with ACI, and bring a better clinical outcome, as compared with the controlled group.]]> 2018/8/17 8:09:35 LI Shao-fa, LIANG Ke, LI Deng-xing, et al. 516true ［Abstract］　Objective　To study the dynamic changes and clinical significance of inflammatory factors in patients with acute craniocerebral injury.Methods　Dynamic measurement of TNF-α,IL-8,IL-10 in 88 patients with acute craniocerebral injury were performed and the date was analyzed statistically.Results　The levels of TNF-α,IL-8,IL-10 remarkably increased immediately after acute craniocerebral injury and the severer the craniocerbral injury,the higher the level of inflammatory factors.Conclusion　The level of inflammatory factors in patients with acute craniocerebral injury can serve as a guideline for judging the injury degree and prognosis.]]> 2018/8/17 8:09:35 DAI Jian-ming,TAN Mei-juan,WU Zhen-hong,et al. 515true ［Abstract］　Objective　To explore the clinical value of laparoscopic surgery combined wath oral guizhifuling capsule, and shenghuatang pills and open surgery in the treatment of ovarian cysts.Methods　The clinical data of 42 patients with ovarian cyst received laparoscopic ovarian cyst surgery combined with oral guizhifuling capsule, and shenghuatang pills (laparoscopy group) and 42 patients with ovarian cyst received open surgery (open seagery group) were retrospectively analyzed.Results　There was no significant stafistical difference in the operative time between laparoscopy group and open surgery group (P> 0.05); blood loss in laparoscopy group was less than that in open surgery group (P<0.05); postoperative remainiug catheter time, exhaust time, and postoperative hospital stay in laparoscopy group were shorter those in the open group (P<0.05); the surgery cost, anesthesia costs and hospital costs in laparoscopy group, were higher than those in open surgery group (P<0.05). Laparoscopy group had good results in postoperative rehabilitation of patients.Conclusion　The laparoscopic ovarian cystectomy is suitable for a variety of benign ovarian tumors. It has the adrantages of less trauma, less postoperative pain, earlie recovery. Combined with oral guizhifuling capsule and, shenghuatang pills it has a good effect in postoperative rehabilitation of patients.]]> 2018/8/17 8:09:35 WANG Li-xiong 514true ［Abstract］　Objective　To investigate the express pattern of T-bet gene and its significance in cervical lymph node of patients with squamous cell carcinoma of the head and neck（SCCHN）.Methods　The fresh and paraffin-imbedding cervical lymph node (CLN) samples of patients with squamous cell carcinoma of larynx, tongue and hypopharynx after radical neck dissection (RND) was respectively subjected to analysis of T-bet mRNA expression by semiquaitative reverse transcriptase-polymerase chain reaction (RT-PCR) and T-bet protein expression by immunohistochemistry.Results　T-bet mRNA average express intensity in above CLN of SCCHN with positive and negative metastasis was respectively (0.118±0.101) and (0.307±0.121), between which the difference was statistically significant（P<0.05）. The positive express rate of T-bet protein in of CLN with positive metastasis in patients with carcinoma of larynx, tongue and hypopharynx was respectively 42.11%, 25.00% and 10.00%, and it was respectively 65.79%, 62.50% and 50.00% in patients with negative metastasis (all P<0.05). In all SCCHN patients, the five years survival rate of patients with positive express of T-bet was higher than that with negative express of T-bet (all P<0.05).Conclusion　SCCHN patients with the positive express of T-bet in CLN has higher survival rate. The CLN with positive express of T-bet has less possibility to suffer from cancer metastasis. The positive express of T-bet can indicate the molecular stage of carcinoma.]]> 2018/8/17 8:09:35 BAI Jian-wen, QU Shen-hong,LUO Chan-qiao,et al. 513true ［Abstract］　Objective　To evaluate the value of CT guided percutaneous fine needle aspiration biopsy in the diagnosis of pulmonary lesions.Methods　A retrospective analysis of the data of pulmonary peripheral lesions from 165 patients received CT-guided percutaneous fine needle aspiration biopsy for pulmonary peripheral lesions were performed.Results　Through surgery, pathology and clinical follow-up malignant tumors were confirmed in 114 cases and benign lesions in 51 cases. Through biopsy malignant tumors were confirmed in 108 cases, the accuracy was 94.7%, false negative in 6 cases, no false-positive was found, Benign lesions were confirmed in 41 cases, the accuracy was 80.4%,Total biopsy accuracy rate was 90.0%. Complications occurred in 11 cases, the rate was 7.0%. Pneumothorax was found in 4 cases, a small amount of pulmonary hemorrhage in 2 cases, intercostal neuralgia in 1 case.Conclusion　CT guided percutaneous fine needle aspiration biopsy of the lung is an effective method of less damage, high accuracy and less complications in the examination and diagnosis of lung diseases and contributes to differential diagnosis with high clinical value.]]> 2018/8/17 8:09:35 ZUO Zi-jun, REN Yin-xiang, WANG Hai-bo 512true ［Abstract］　Objective　To investigate beneficial effects of esmolol on postoperative pain, postoperative nausea and vomiting (PONV) in controlled hypertensive patients undergoing laparoscopic cholecystectomy.Methods　Fifty consecutive ASA classⅡpatients with controlled hypertension undergoing laparoscopic cholecystectomy were randomized into two groups. The esmolol group (Group E, n=25) was given intravenous injection of 1 mg·kg^-1 bolus of esmolo and the placebo group (Group P, n=25) was given an identical volume of Ringer′s lactate. The rate of esmolol infusion was 5～10 μg·kg^-1·min^-1 throughout the procedure and was adjusted to keep the heart rate between 65～75 beats/min. After pulling out the trached intubation drug use was stopped.After operation, patients reported the nausea using a four-point scale.Results　Esmolol had an opioid-sparing effect intraoperatively (P<0.01). Postoperative requirements for antiemetics were significantly less in the esmolol group, with no antiemectics given to nine patients. In the placebo group, however, all patients required at least one dose of antiemetic (P<0.01). The frequency of PONV did not correlate to the amounts of remifentanil, propofol, postsperative antiemetics consumed, or to female gender, non-smoking status, and history of PONV or motion sickness. Postoperative analgesic consumption in Group E was significantly lower than that in Group P (P<0.05).Conclusion　Esmolol has an opioid-sparing effect in the intraoperative and immediated postoperative period in hypertensive patients undergoing laparoscopy. When combined with remifentanil, it is more effective than placebo in decreasing early PONV.]]> 2018/8/17 8:10:44 WANG Qi-min,SONG Qiong 511true ［Abstract］　Objective　To investigate the difference of plasma level of B-type natriuretic peptide(BNP) in patients with coronary disease and correlation between BNP level and plasma cardiac troponin I(cTnI) in patients with acute coronary syndrome(ACS) and to explore the value of BNP in the risk stratification in acute coronary syndrome(ACS).Methods　The levels of plasma BNP and cTnI among 78 ACS patients，42 stable angina pectoris(SAP) and 30 without coronary heart disease(CHD) as control were measured by ELISA. The ACS patients were divided into cTnI positive group(48 patients) and cTnI negative group(30 patients). Patients with ACS were followed up for 60 days. The end point was cardiac events including new or recurrent myocardial infraction，new or progressive congestive heart failure，and cardiac death.Results　Plasma BNP levels were significantly higher in ACS group (138.10±4.85)pg/ml than SAP group (30.62±1.08)pg/ml and without CHD group (29.27±1.45)pg/ml (P<0.05). There was no significant difference between without CHD group and SAP group in serum BNP levels (P>0.05). The level of BNP was significantly higher in ACS patients with cTnI(+) group than that with cTnI(-) group (P<0.05). BNP level was positively correlated with cTnI in ACS patients (r=0.57, P<0.05). The plasma level of BNP>80 pg/ml group was correlated with higher rates of new or recurrent MI and new or recurrent CH (P<0.05) than that of BNP≤80 pg/ml group. Conclusion　The level of BNP was significantly high and positively correlated with cTnI in ACS patients. BNP has practical significance in evaluating the short-term out-come of ACS. It could be used as a marker for risk stratification of ACS.]]> 2018/8/17 8:10:44 LUO Ge-nan，YAN Li-qun 510true ［Abstract］　Objective　To discuss the clinical significance of esophagus variceal ligation combined with gastric fundal varices tissue iatrotechnics in treatment of acute gastroesophageal variceal bleeding caused by hepatocrrhosis.Methods　Fifty-six patients,with diagnosed acute gastroesophageal variceal bleeding caused by hepatocirrhosis and portal hypertension, were treated with esophagus variceal ligation combined with gastric fundal varices tissue iatrotechnics within 24 hours after bleeding，and were followed up by endoscopy at 1 month,3 months, 6 months after operation,and the re-bleeding rate and the conditions of gastroesophageal varices were observed.Results　All the patients obtained successful hematischesis. Five cases showed re-bleeding within 1 month, including 3 patients with light bleeding during discharging tissue glue, and 2 patients with more bleeding. The 5 patients obtained newly hematischesis by endoscopic insufflation norepinephrine, and no bleeding recurred in 5 patients within 6 months. The effective rate of treatment for esophageal varices was 96%, and that for gastric fundus varices was 95%.Conclusion　The endoscopic histoacryl injection combined with variceal ligation in the treatment of acute gastro esophageal variceal bleeding caused by hepatocirrhosis is a therapeutic method of safe and definite curative effect.]]> 2018/8/17 8:10:44 ZOU Yong-jun,CAO Jie,DU Xue-mei, et al. 509true ［Abstract］　Objective　To observe the postoperative effects of artificial joint in adult patients with avascular necrosis of the femoral head.Methods　Postoperative effects of artificial joint in 72 adult patients with avascular neorosis of the femoral head were retrospectiveiy analyzed.Fifty-nine cases were male and 13 female aged 38～75 years,and 36～60 years old in 18 cases,61～70 years old in 47 cases,71～75 years old in 7 cases,with an average age of 62 years.Of them alcoholic avascular necrosis of the femoral head were diagnosed in 32 cases,femoral neck fracture and dislocation of the hip in 27 cases; avscular necrosis of the femoral head due to corticoids in 10 cases,unknown cause in 3 cases;double side osteonecrosis of femoral head in 7 cases,the one-side in 65 cases; 38 cases suffered from cardiovascular diseases and 6 cases suffered from chronic bronchitis.The types of the operation included prosthetic replacement for femoral head in 20 cases,total hip arthroplasty in 52 cases.Twenty-six cases were treated by cement total hip arthroplasty, 23 cases were treated by cementless total hip arthroplasty, and 3 cases were treated bigmixed cement, of them artificial joint were rebuilt in 4 cases. Results　The 72 cases were cured. Dislocation of artificial joint were found in 3 cases; deep vein thrombosis in 3 cases. Break off artificial femoral handle in 1 case;stress ulcer in 1 case. The follow-up period ranged from 2 years to 10 years and 6 months, with an average of 5.6 years. The mean Harris hip score increased from 40.3 points before operation to 91.5 points after operation. Conclusion　Effects of artificial hip arthroplasty for avascular necrosis of the femoral head are exallent.]]> 2018/8/17 8:10:44 YOU Jian-ming,LUO Yu-chen,CHEN Zhi, et al. 508true ［Abstract］　Objective　To summarize the experience and skills on breast augmentation by transplanting auto-fat granule in patients with mastatrophy post suckling. Methods　Total of 91 patients who wanted both liposuction and breast augmentation with mastatrophy post suckling were transplanted auto-fat granule by injection in our department from January 2000 to December 2007. The auto-fat granule was obtained by liposuction with syringe from patient′s abdomen, waist, buttocks and thighs, etc. After repeated wash and purification, the auto-fat granule was transplanted into the interspace behind the breast by injection. The quantity of auto-fat granule injected was 50～100 ml in each side of breast per transplantation at 3～6 months intervals, and the whole course of treatment needed 2～6 transplantations. Results　Seventy-six of 91 cases were followed up from 6 months to 3 years post operation. All patients had a significant improvement in their breast size and shape postoperatively and their breasts were all soft and natural in appearance and feel. All of them have more perfect arcuation of physique and body with strengthened self-confidence, relieved mood and improved quality of life. Small indurations were found sporadically in 9 cases (14 breasts), and calcifications in 8 cases (11 breasts). Conclusion　Both patients and surgeons were satisfied with the results. The transplantation by auto-fat granule injection for mastatrophy post suckling is an effective and practical method. The surgical technique is well worth performing in clinical practice.]]> 2018/8/17 8:10:44 FANG Min,CHEN Yang 507true ［Abstract］　Objective　To explore the variation of P-wave dispersion (P_d) before and after transcatheter closure of atrial septal defect (ASD).Methods　At the day before having transcatheter closure and within 3 days after having transcatheter closure, P-wave maximum time limit (P_max), P-wave minimum time limit (P_min) and P_d from 12-lead synchronous electrocardiograms in 65 patients with ASD were measured, then comparing and analyzing each of them respectively.Results　The recorded data for the day before having transcatheter closure and within 3 days after having transcatheter closure were both as follow: The P_max were (105.16±12.25)ms and (99.92±13.86)ms, the P_min were (86.61±12.41)ms and (84.76±11.75)ms, the P_d were (18.55±9.77)ms and (15.16±7.99)ms. The results showed that both P_max and P_d had notable distinctions (P<0.05).Conclusion　ASD transcatheter closure treatment not only reshapes the right heart, also largely recover the cardiac function, such as shortening the atrial conduction time, promoting the stability of atrial electrical activity, and what is more, effectively reducing the probabilities of occurring atrial arrhythmias. Therefore, P_d measurements can be the key indicator of diagnosing and identifying arrhythmias from ASD cases.]]> 2018/8/17 8:10:44 SUN Zhong-bo, ZHANG Qin, TIAN Xiao-fen, et al. 506true ［Abstract］　Objective　To discuss the delivery way of the re-pregnacy after cesarean section.Methods　From January 2008 to September 2009, the ways of childbirth，the results of childbirth and the cost in the 156 cases of re-pregnacy after cesarean section randomly selected were retrospectively analyzd.Results　Among 156 cases of re-pregnacy after cesarean section，125 cases received repeated cesarean section (RCS) (112 cases received selective cesarean section, 13 cases received cesarean section after failure of trial of vaginal labor)，accounted for 80.13%；the trial of vaginal labor were adopted in 44 cases, accounted for 28.21%；the VBAC 31 cases, accounted for 19.87%；the success rate of trial of vaginal labor was 70.45%.The quantity of postpartum hemorrhage of RCS was more than that of VBAC, ［(85.5±8.5)ml、(175.7±4.0)ml］,and the average days of hospitalization were more than that of VBAC,［(8.20±1.58)d、(3.20±0.42)d］,and the cost of RCS was higher than that of VBAC.Conclusion　Cesarean section history is not the absolute indication of cesarean section， vaginal birth is possible under intensive monitoring.]]> 2018/8/17 8:12:31 JIANG Yong-hong 505true ［Abstract］　Objective　To evaluate the prognostic significance of the micropapillary lung adenocarcinoma and to determine the biological behavior of this type of lung cancer according to the immunchistochemical configurations.Methods　The 63 cases of resected lung adenocarcinoma included 21 cases of micropapillary lung adenocarcinoma and 42 cases of non-micropapillary lung adenonocarcinoma.The lesions in 12 cases of micropapillary lung adenocarcinoma at stage Ⅰ and in 23 cases of non-micropapillary lung adenocarcinoma at stage Ⅰwere compared.Results　The 5-year survival rates of the cases of the micropapillary lung adenocarcinoma and the cases of non-micropapillary lung adenocarcinoma were 52% and 73% respectively （log rank P=0.03）.The multivariate survival analysis showed that micropalliary component was an important factor for prognosis with the survival risk ratio being 3.2.The prognostic value was evaluated according to the different expressions of immunologic marks of micropapillary lung adenocarcinoma at stage Ⅰ.Only the expressions of Cyclin DI and Bax were related with significantly worse survival（log rank P=0.03 and P=0.02）.Conclusion　It is important to identity micropapillary lung adenocarcinoma and Bax and Cyclin DI can act as marks of poor grognosis.]]> 2018/8/17 8:12:31 ZHANG Feng 504true ［Abstract］　Objective　To evaluate the clinical effects of autogenic and allogenic bone- patella tendon-bone（B-PT-B）reconstruction of anterior cruciate ligament (ACL) under arthroscopy.Methods　According to requirements of patients, selected respectively the autogenic or allogenic B-PT-B reconstruction of ACL under arthroscopy. For the ACL injuried patients which were examined by MRI before operation and by arthroscopy on operation, chose the autogenic or allogenic B-PT-B reconstruction of ACL under arthroscopy, fixed the grafts by interference screws, observed and recorded the symptoms before and after the treatment respectively and postoperative Lysholm score. The follow-up time after operation were 6 to 24 months and the average were 16.7 months.Results　The severe complications of the cases didn′t occur and the function of knee joint was ameliorated; otherwise, the objective indicators were normal. The operation time of the autogenic group was ［average （80±10）min］ and the allogenic group was ［average （60±10）min］. The postoperative fever time of the autogenic group was ［average （2±1）d］ and the allogenic group was ［average （3±1）d］.According to Lysholm score, the result of the autogenic group was ［average （86.7±4.3)min］ and the allogenic group was ［average （85.8±4.4)min］.According to Lukiano sore, the good-rate of the autogenic group was 92.5% and the allogenic group was 90.09%.The range of knee activity was equally normal of the two group.Conclusion　Compared to allogenic B-PT-B reconstruction of ACL under arthroscopy, the autogenic time of operation is longer and absorption of heat after operation is shorter. The clinical effect has no significant differences between the two groups. Allogenic B-PT-B reconstruction has no obvious immune rejection, and avoids the autologous tissue injury by autogenic B-PT-B reconstruction. Therefore allogenic B-PT-B is one of the best choice of the reconstruction of ACL.]]> 2018/8/17 8:12:31 JIN Xian-yue，LI Hong-yu，LIANG Jian-min，et al. 503true ［Abstract］　Objective　To evaluate the pathogenesis of atonic pupil following cataract surgery.Methods　Retrospective study on atonic pupil following cataract surgery from January 2004 to December 2009 in Beihai No.2 people′s hospital was performed.Results　Twenty-two eyes with atonic pupil in 1 812 cataract surgery were found and the incidence rate was 1.21%. All pupils showed moderate dilatation, atony and failure in reaction to light, absence of accommodation reflex, no response to myotic agents and tention-free status.Conclusion　The pathogenesis of atonic pupil was complex and uncertain. Until now, there is no effective therapy to this disease, and prevention should be emphasized.]]> 2018/8/17 8:12:31 LI Jun-ning, HE Zhen 502true ［Abstract］　Objective　To investigate the clinical effect and the incidence of complications of the RPH combined with srugery in the treatment of hemorrhoids. Methods　In our hospital from February 2008 to January 2010, 100 patients with hemorrhoids were randomly divided into treatment group and control group (50 patients in each group)， the treatment group received RPH and surgical treatment， the control group received only RPH， the clinical symptoms and complications in two groups were observed and compared. Results　The effective rate of the treatment group was higher than that of the control group， by statistical analysis， the difference was significant (P<0.05). There was no statistically significant difference in the operation time, pain index, wound healing time, shedding time of rubber band between two groups (P>0.05). In treatment group， postoperative urinary retention with mild symptoms was found in 1 case， whose urination became normal quickly after induction of the local hot; almost no bleeding during surgery was found; patients suffered less pain with mainly heavy feeling in the anal area; anal mild edema in 2 cases， no case had complications such as secondary haemorrhage， infection，anal stenosis. The incidences of postoperative complications in control group were significantly higher than those in the treatment group， the difference was significant (P<0.01). Conclusion　The treatment of hemorrhoids by RPH combined with surgery has advantages of excellent efficacy， simple operation， less pain， almost no complications， is worthy of promotion.]]> 2018/8/17 8:12:31 LI Chao-ping 501true ［Abstract］　Objective　To study the clinical significance of the dendritic cells（DCs) and cytokine induced killer cell（CIK) in treating advanced malignant tumors. Methods　From March 2010 to September 2011, peripheral blood mononuclear cells(PBMCs) of 130 patients with advanced malignant tumors were isolated, and then were incubated in vitro with IFN-γ, IL-2 and anti-CD3 monoclonal antibody. The total number of DCs-CIK cells per patient expanded, and then were transfused back to the patients with one time. The changes of tumor weight, clinical symptoms, and toxicity in the patients were observed before and after DCs-CIK cells being transfused back. Results　After treatment, complete remission(CR) was achieved in 5 patients, partial remission(PR) in 19 patients, stable disease(SD) in 87 patients, progressive disease(PD) in 13 patients, 6 patients died. Conclusion　Adoptive immunotherapy with DCs-CIK cells is safe, effective, probably which provide a new strategy for the patients with advanced malignant tumors.]]> 2018/6/28 8:50:28 LIN Hui，FENG Guo-sheng,CHEN Lin，et al. 500true ［Abstract］　Objective　To explore the influence of oligohydramnios on mode of delivery and perinatal infants.Methods　One hundred parturient women with oligohydramnios in term pregnancy was chosen as the experimental group, while 100 healthy parturient women as the control group.Each group got appropriate way of delivery according to her specific situation.Results　(1) The rate of cesarean section of experimental group was significantly higher than that of the control group (P<0.05); (2) In the experimental group cesarean section related indicators such as bleeding, anal discharge, length of stay, postoperative complications were worse than the control group, but no significant difference between two groups (P>0.05); (3) In the experimental group, the indicators of natural delivery were so same as the above;(4) Perinatal infants with ≥Ⅱ degree of amniotic fluid contamination,neonatal asphyxia, fetal distress, anoxia, etc. in experimental group were significantly higher than those in the control group(P<0.05).The mortality of them was also higher, but no significant difference between two groups (P>0.05); (5)As to modes of delivery in the experimental group, the occurrence rate of perinatal complications in cesarean section was lower than that in natural delivery, but there was no significant difference between them(P>0.05).Conclusion　The modes of delivery and birth outcomes were affected mainly by oligohydramnios, and delivery mode did not significantly affect the outcome. Patients with oligohydramnios should be early diagnosed, timely treated, so as to improve the prognosis.]]> 2018/6/28 8:50:28 HUANG Hong-ying, HUANG Su-ran, HE Qing-ping, et al. 499true ［Abstract］　Objective　To compare the practical results of two post cores ( Anthogyr root-canal stainless steel post and glass-fiber post)through the methods of instantly restoring the residual crown and then restoring the residual crown for permanent ceramic crown. Methods　One hundred and twenty-two patients with 130 tooth were randomly divided into two groups, every group was 65 tooth. Two methods (Anthogyr root-canal stainless steel post and glass-fiber post) were used for restoring the molar residual crown respectively, and every group was treated through light-cure tetric ceram repairing the residual crown and then then restoring the residual crown for permanent ceramic crown. The operation time and the success rate were compared.Results　Two years follow-up showed，in the group of Anthogyr root-canal stainless steel post three stainless steel post were curved and displaced, and the operation time was shorter than that of group of glass-fiber post (P<0.01). But there was no statistical significance in the success rate between the two kinds of posts (P>0.05).Conclusion　The anthogyr root-canal stainless steel post and the glass-fiber post have similar curative effect. But the former which has advantages of special design, hard retainer, simple operation and lower cost, is worth popularizing and applying.]]> 2018/6/28 8:50:28 LU Shan, LIANG Jian- mei, ZHOU Yan-ping, et al. 498true ［Abstract］　Objective　To study the efficacy of trimebutine and wuling capsule in the treatment of functional dyspepsia(FD).Methods　One hundred and fifty FD patients were randomly divided into two groups. The observation group(n=80) were given 100mg trimebutine (3 times a day) and 0.99 g wuling capsule（3 times a day); The control group (n=70) were given 100 mg trimebutine (3 times a day ),for 8 weeks. Clinical symptoms were compared.Results　The total effective rates were 88.8% and 55.7% in observation group and control group, respectively. The difference between two groups was significant (P<0.05). There was no severe side effect in two groups.Conclusion　The therapeutic effect of trimebutine combined with wuling capsule in treating FD is satisfactory and safe.]]> 2018/6/28 8:50:28 LI Liang 497true ［Abstract］　Objective　To explore how to apply the maternal and child health projects to improve the work of maternal and child health.Methods　Five maternal and child health projects were implemented in Baise city. By strengthening the management of projects, increasing investment, strengthening infrastructure, improving the quality and business level of operational staff, strengthening health education and promotion, effectively using funds of projects, the main tasks of the maternal and child health work were completed and health indexes were improved significantly.Results　(1)The city′s main indexes: mortality of children under five, infant mortality, the incidence of neonatal tetanus, the incidence of low birth weight, maternal mortality, the incidence of low body weight in under-five children, birth defect rate achieved country′s, Guangxi′s and Baise′s requirement of “Two Outlines” indexes. (2)Basic indexes: rural child health coverage rate, urban maternal health coverage rate, rural maternal health coverage rate, hospital delivery rate in rural areas, rural high-risk hospital delivery rate,and so on achieved the country′s,Guangxi′s and Baise′s requirement of the indexes; hospital delivery rate achieved Guangxi′s and Baise′s requirements of “Two Outlines” indexes; hospital delivery rate,and the rural hospital delivery rate were the first time more than 90%, reaching a record high peak.Conclusion　The implementation of comprehensive maternal and child health projects in poor areas is successful. It is a practical mode of maternal and child health,and can push the overall cause of maternal and child health in poor areas to develop forward.]]> 2018/6/28 8:50:28 LIANG Li，NONG Jian-wei 496true ［Abstract］　Objective　To explore the multicenter clinical trials on the automated hematology analyzer.Methods　Trial instrument (URIT-3010) and control instruments（XE-2100 and COULTER LH750） were used for measuring the WBC,RBC,HGB,MCV and PLT of the blood samples respectively, calculating the absolute value of relative error (Se) as major indicators of effect to calculate the mean value of Se and 95% confidence intervals of the average. The results were compared to the admissible error regulated by state food and drug administration (SFDA).Results　The upper limits of 95% confidence interval of the mean value of Se for WBC、RBC、HGB、MCV and PLT were all lower than those of the admissible error regulated by SFDA.Conclusion　URIT-3010 is equivalent to the control instruments XE-2100 and COULTER LH750.]]> 2018/6/28 8:50:28 QIN Gui-fang，QIN Xue，MO Zhi-jiang，et al. 495true ［Abstract］　Objective　To analyze the epidemiological characteristics of rabies in Xuchang city so as to provide the evidences for prevention measures.Methods　The data of rabies disease in Xuchang city from 1992 to 2010, were collected and analyzed by descriptive epidemiology method.Results　 The cases of Xuchang city mainly occured in aged 30～59, peaked in country, and more in male than female, and mainly occurred in summer and autumn.Conclusion　It is necessary to strengthen the management of dogs, promote the standard prevention after the wound of exposing, and improve the control of rabies in order to reduce the morbidity and mortality of this disease.]]> 2018/6/28 8:50:28 JIA Gui-hua 494true ［Abstract］　Objective　To explore differential diagnosis role of multiple tumor marker protein biochip detective system for giant gastric ulcer.Methods　Using multiple tumor marker protein biochip C12 to detect 133 inpatients with giant gastric ulcer diagnosed by histopathology and endoscopy from January 2007 to October 2010.Results　There were significant statistical difference in level of CEA,CAl25,CA242,CA19-9,AFP between two groups (P<0.05).There were no statistically significant difference in other tumor markers between two groups (P>0.05).In positive rates of CEA,CAl25,CA242,CA19-9 there were statistically significant difference between two groups (P<0.05).Conclusion　C12 multiple tumor marker protein biochip detective system is a kind of tumor marker detection technology.This system can be used to meanwhile monitor 12 kinds of tumor markers in the same system.Compared with traditional detection method,this joint detection can make up for insufficiency of single parameter testing,and having certain application value for differential diagnosis of giant gastric ulcer.]]> 2018/6/28 8:51:28 QIN Hai-Chun,FAN Hong 493true ［Abstract］　Objective　To study the effect of the reoperation with prosthetic valve replacement.Methods　Between January 2002 and January 2011，the clinical data of 25 patients undergoing cardiac valve replacement again were retrospectively analyzed. The interval between two procedures was 0.5 to 15 years average 9（10.5±1.5）years.All operations were performed in cardiopulmonary bypass(CPB). Of them,10 patients underwent arrested heart operation, and 15 patients underwent beating heart operations.The heart valve replacement included MVR in 13 patients， AVR in 10 patients，TVR in 2 patients.Results　The aortic clamping time was 55～158（89±34）min；The average CPB time was 80～204(112±32）min，no patient died in the admission period and the hospitalized time were 15～30 d ［average（20.5±2.5）d］.The cardiac function of all surviving patients was improved，including NYHA class Ⅰ in 16 patients and class Ⅱin 9 patients.Conclusion　Proper timing in reoperation with prosthetic valve replacement should be chosen，and traditional prosthetic valve replacement by open heart surgery with arrested heart and beating heart can be used.The surgery is proved valuable and can improve the prognosis of the patients.]]> 2018/6/28 8:51:28 MENG Wei-ping,TAN Ning,WU Xun-ning 492true ［Abstract］　Objective　To evaluate the effect of sequential non-invasive following invasive mechanical ventilation for severe acute cardiogenic pulmonary edema. Methods　Thirty-two patients with severe acute cardiogenic pulmonary edema were randomly divided into two groups with 16 patients in each group. All patients received routine drug therapy and endotracheal intubation. Sixteen patients in sequential therapy group were ventilated by synchronized intermittent mandatory ventilation + pressure support ventilation (SIMV+PSV) mode mechanical ventilation. The endotrachenl intubation was removed after a pulmonary edema control window appeared and changed to two-level positive airway pressure(BiPAP) support ventilation and weaned from mechanical ventilation. The control group was weaned from mechanical ventilation by SIMV+PSV means. The parameters of hemodynamics, oxygendynamics were measureed during invasive mechanical ventilation, two hours after oxygen therapy, after non- invasive mechanical ventilation. The number of death patients, the number of patients of VAP, the number of patients of re-intubation, time of invasive mechanical ventilation and time of general ventilation time were compared between two group. Results　There were no significant difference in respiratory and circulatory parameters after treatment in BiPAP group(P>0.05). The number of patients of VAP, the number of patients of re-intubation, the time of invasive mechanical ventilation and time of total duration of mechanical ventilation in sequential therapy group were less than those in the control group (P<0.05). Conclusion　Sequential non-invasive following invasive mechanical ventilation for severe acute cardiogenic pulmonary edema have more secure and reliable results compared with invasive mechanical ventilation alone.]]> 2018/6/28 8:51:28 ZHAO Kai-liang, YANG Xin-jiang 491true ［Abstract］　Objective　To evaluate the effects of anti-oxidant α-lipoic acid on diabetic peripheral neuropathy. Methods　Sixty patients with type 2 diabetes mellitus with varying degrees of neuropathy were randomly divided into two groups, the treatment group (n=32) was treated with α-lipoic acid and the control group (n=28) with Calomide-Me. The course was two weeks. Effects were observed after 2 weeks of treatment. Results　Compared with the control group, the clinical efficacy and peripheral nerve conduction velocity in treatment group were significantly improved after treatment. During treatment, the two groups had no significant adverse events. Conclusion　α-lipoic acid in the treatment of diabetic peripheral neuropathy is safe and effective.]]> 2018/6/28 8:51:28 XU Wen-jian, LIU Guo-feng, SUN Shun-cheng 490true ［Abstract］　Objective　To observe the change rules of renal function in neonates with hyperbilirubinemia and explore the prognosis of damage of renal function in neonates with hyperbilirubinemia.Methods　In 63 neonates with hyperbilirubinemia and 30 neonates without hyperbilirubinemia at the first 3 days after the birth blood urea nitrogen, serum creatinine and β₂-microglobulin were determined. In 63 neonates with hyperbilirubinemia at the first 7，10，14，21 days after the birth serum β₂-microglobulin were determined.Results　At the first three day after the birth serum β₂-microglobulin (4.43 ± 0.8）mg·L^-1 in hyperbilirubinemia group was higher than that in the not hyperbilirubinemia group (1.5± 0.26)mg·L^-1 (P<0.01), and β₂-microglobulin in moderate hyperbilirubinemia group (4.54±0.22）mg·L^-1 was higher than that in mild hyperbilirubinemia group (3.49±0.29）mg·L^-1 (P<0.05), β₂-microglobulin in severe hyperbilirubinemia group (5.34± 0.16）mg·L^-1 was higher than that in moderate hyperbilirubinemia group (P < 0.05). The levels of serum β₂-microglobulin in mild, moderate, severe hyperbilirubinemia groups reduced to the normal range respectively at the first 10, 14, 21 days after the birth. The linear correlation analysis showed there was highly linear positive correlation between level of blood bilirubin and serum β₂-microglobulin (r=0.96, P<0.01).Conclusion　When neonatal hyperbilirubinemia occurs β₂-microglobulin significantly increase, glomerular filtration rate drop, and with the increase of concentration of blood bilirubin its drop increase, heavier high bilirubin degree slower its restore, but high bilirubin induced renal impairment is temporary and its prognosis is good.]]> 2018/7/2 15:40:24 YANG Ming，SUN Qun 489true ［Abstract］　Objective　To investigate the effect of nerve growth factor on stromal cell proliferation and estrogen receptor α(ERα) expression of eutopic endometrial cells of adenomyosis uterine.Methods　The eutopic endometrial cells were isolated,cultured and identified in vitro,then added to 10 ng/ml,50 ng/ml,100 ng/ml NGF.The growth and proliferation of the stromal cells were measured by MTT assay;Westen-blotting was used to measure the changed ERα.Results　50 ng/mlNGF could accelerate the proliferation of eutopic endometrial stromal cells of adenomyosis uterine,it showed a significant difference compared to other group(P<0.05);The expression of ERα in eutopic endometrial stromal cells were significantly increased after the treatment of 50 ng/ml NGF(P<0.01).Conclusion　50 ng/ml NGF can significantly accelerate the cell proliferation of eutopic endometrial stromal cells of adenomyosis uterine and increase the expression of ERα.]]> 2018/7/2 15:40:24 XIE An-tuan 488true ［Abstract］　Objective　To explore the serum levels of IL-6 and CRP in overweight and obesity persons.Methods　Thirty-seven normal weight persons and 42 overweight and obesity persons were taken fasting blood samples for measurements of plasma glucose, plasma lipids, insulin, C-reactive protein(CRP),interleukin-6 (IL-6).Results　The levels of IL-6 in overweight and obesity persons were significant higher than those in the normal weight persons（P<0.05）. Pearson relation analysis showed that serum IL-6 and CRP levels were positively and significantly correlated with body mass index.Conclusion　The levels of serum IL-6 and CRP were higher in overweight and obesity persons, and suggests that inflammation might be closely correlated to overweight and obesity.]]> 2018/7/2 15:40:24 WANG Quan-ming,PENG Yun-bo,QIN Yong-qi 487true ［Abstract］　Objective　To explore the clinical effect and feasibility of treatment for lumbar intervertebral disc herniation by low - temperature plasma radiofrequency ablation nucleoplasty.Methods　A total of 47 patients with lumbar intervertebral disc herniation between January 2009 and October 2010 were reviewed retrospectively. These patients were treated by low-temperature plasma radiofrequency ablation nucleoplasty， the operation time,the blood loss and the length of stay were counted.Just before and at 1 h, 1 d,2 d,3 d,3 months and 1 year after the treatment，the low lumbar pain and functions were evaluated by using the visual analogue scales (VAS) and the Oswestry disability index (ODI). The effects were evaluated by using Macnab standard at 3 months and 1 year after operation.Results　The operative time was (20±10)minutes, the blood loss was (4±1)ml, the length of stay was (4±1)d.All the patients were followed-up for (15±2)months. There were statistically significant differences between the preoperative and the postoperative scores (P<0.05).Conclusion　The percutaneous low - temperature plasma radiofrequency ablation nucleoplasty for lumbar intervertebral disc herniation has advantages of simple operation， safty, excellent curative effect.]]> 2018/7/2 15:40:24 CHEN Chao，ZHENG Yan-ke，ZHAO Min,et al. 486true ［Abstract］　Objective　To observe the eradication rate of Helicobacter pylori(Hp) and its security of quadruple program of proton pump inhibitors(PPI), bismuth, furazolidone and levofloxacin in the treatment of patients with gastroduodenal diseases which was associated Hp.Methods　One hundred and fourty-two patients with Hp associated gastroduodenal diseases were divided into two groups randomly. In the treatment group 72 patients was treated with quadruple program for 10 days, and the control group 70 patients was treated with standard triple therapy(PPI+Amoxicillin+Clarithromycin) for 10 days. Hp was reexamined in all patients in two group 1 months after treatment.Results　The eradication rate of Hp in treatment group(91.67%) was significantly higher than that(71.43%) in control group (P<0.05).Conclusion　There is a high eradication rate of Hp and little side effect in patients with Hp associated gastroduodenal diseases treated with quadruple program consisting of PPI, bismuth, furazolidone and levofloxacin, so it is worthy of clinical application.]]> 2018/4/27 8:24:40 LUO Yi 485true ［Abstract］　Objective　To find an ideal method in the treatment of skin lacerations.Methods　One hundred and forty patients with skin laceration were randomly divided into two groups, with 70 patients in each group. The control group was treated by traditional debridement and suture, and the experimental group was treated by adhesive and debridement. The situation of wound healing and satisfactory degree of postoperative cosmetic appearance were followed up 1, 2, and 7 days after the treatment.Results　There was no statistically significant difference in the situation of wound healing between two groups(P>0.05); but the satisfactory degree of postoperative cosmetic appearance in the experimental group was better than that in the control group（P<0.01）.Conclusion　Compared with debridment and suture, debridement and adhesive is a better treatment for the wound of skin laceration, which saves the time and improves the patients′ satisfactory degree.]]> 2018/4/27 8:24:40 FU Guo 484true ［Abstract］　Objective　To evaluate the effects of isosorbide mononitrate sustained release tablets combined with metoprolol sustained-release tablets on the preventing of recurrence of angina pectoris recurrent.Methods　Fifty-two patients with angina pectoris were randomly divided into treatment group (take isosorbide mononitrate sustained release tablets combined with metoprolol sustained-release tablets) and control group (take isosorbide mononitrate sustained release tablets), 4 weeks later the clinical outcomes of the two groups were evaluated.Results　After treatment, the total effective rate accounted for 92.31% in treatment group, while 65.39% in control group (P<0.05); the attack frequency of angina pectoris after 2 weeks in treatment group was greatly reduced contrast pretreatment and control group (P<0.05).Compared to pretreatment the lasting time of angina pectoris in treatment group was shorter (P<0.05), and were markedly different between treatment group and control group after 4 weeks (P<0.05). There was no significantly difference in electrocardiogram effective rate between groups. There were no severe adverse reaction was found in two groups.Conclusion　Isosorbide mononitrate sustained release tablets combined with metoprolol sustained-release tablets is effective and safe in preventing of recurrence of angina pectoris, and more effect than Isosorbide mononitrate sustained release tablets.]]> 2018/4/27 8:24:40 LIN Fu-sheng, LIN Xin-yue 483true ［Abstract］　Objective　To investigate the diagnostic value of fine needle aspiration of cell block (FNACB) combined with fine needle aspiration cytology (FNAC) in diagnostis of the superficial lymph nodes.Methods　Sixty patients whose enlarged superficial lymph nodes were identified as positive by FNAC received FNACB and subsequent biopsies were performed. The difference of the diagnostic accuracy rate between FNAC smears and FNACB combined FNAC smears were compared. ICC was performed to some poorly differentiated malignant tumors which prepared for cell blocks. The date was managed statistically.Results　Compared with histopathological results,the diagnostic accuracy rate of FNAC routine smears as follows: squamous cell carcinoma (SCC), 70.0%(14/20); adenocarcinoma(AC), 65.4%(17/26); indefinite cell types diagnosis,20 cases(33.3%). The diagnostic accuracy rate of FNACB combined FNAC routine smears as follows: SCC,95.0%(19/20); AC,96.2%(25/26); indefinite cell types diagnosis,7 cases(11.7%).There was a statistical difference between them (P<0.05).Conclusion　Application of cell block compared with FNAC in diagnosis of the superficial lymph nodes can significantly increase the diagnostic accuracy rate of lymph node metastatic carcinomas, especially for SCC and AC,and have a high applied value in histological typing and classification, but there are still some limitations in diagnosis of malignant lymphomas and some rare metastatic carcinomas.]]> 2018/4/27 8:24:40 LI Yin, HE Hai-sheng 482true ［Abstract］　Objective　To study the clinical effect of the open reduction and closed reduction in the treatment of elderly distal radial fractures.Methods　According to random number table 66 elderly patients with distal radial fractures were randomly divided into open reduction group and closed reduction groups,with 30 patients in eath group,and were treated by surgery or manipulation therapy respectively.The fracture healing and function recovery of wrist joint were observed.Results　In open reduction group and closed reduction group the fracture healing time were (11.2±2.3) weeks,(10.8±2.1) weeks respectively,there was no statistical difference between two groups(P>0.05).Volar tilting angle,ulnar inclination angle,the length of radius and function recovery of wrist joint in the open reduction group were superior to those in the closed reduction groups.Conclusion　The patients with distal radial fractures can be treated by open reduction and internal fixation.Adopting these therapentical measures will enable patients to obtain reliable radial length recovery,early functional exercise to promote joint function recovery,shorter recovery time,the ideal reduction quality and curative effect.]]> 2018/4/27 8:24:40 LI Jia-qing,LI Zhuo-qiu 481true ［Abstract］　Objective　To explore the signifance of cognitive impairment of migraineurs detected by event-related potential(ERP)-auditory P300.Methods　Thirty-five migraineurs without aura in interval period and 32 healthy controls were examined with auditory P300.Migraineurs were examined with auditory P300 again after treatment.Results　The N2 peak-baseline amplitude (P-B Amp) and P3 peak-peak amplitude (P-P Amp) in migraineurs were significantly lower than those in controls. No changes of peak latency (PL) were found. There was no significant difference of all P300 parameters before and after treatment.Conclusion　Migraineurs had mild cognitive impairment and P300 could be the sensitive and objective method for analyzing the cognitive function of migraineurs. The cognitive impairment could not be improved along with the improvement of headache.]]> 2018/4/27 8:24:40 ZHENG Chun-hui, FU Qiu-zhen, LI Qiu-li 480true ［Abstract］　Objective　To analyze the correlation between the use of antibiotics during perioperative period and incision infection in three kinds of clean operation.Methods　An investigation on the patient history and the use of antibiotics during perioperative period in the patients of breast, thyroid and hernia surgery in people′s hospital of Guangxi Zhuang Autonomous Region from January to March 2011(group A) and January to March 2012 (group B) was carried,and the correlation between the use of antibiotics and incision infection was analyzed.Results　In 344 cases of clean operation,the usage rate of antibiotics in group A (n=187) was 95.83%(46/48) in breast surgery, 100.00%(61/61) in thyroid surgery, 100.00%(78/78) in hernia surgery, and in group B (n=157) the usage rate was 5.41%(2/37) in breast surgery, 6.98%(3/43) in thyroid surgery, 31.17%(24/77) in hernia surgery. The usage rate of antibiotics in group A was higher than that in group B，there was statistically significant difference （P<0.01）. The incidence of incision infection of group A and group B were 0.00%,there was no statistically significant difference（P>0.05）. Conclusion　There was no correlation between the use of antibiotics and incision infection rate in perioperative period of cleaning operation. Antibiotics can be avoided in the patients with no high risk factors in perioperative period of cleaning operation.]]> 2018/4/27 8:24:40 LAN Shun, YE Dong-mei,LIU Liu-mei 479true ［Abstract］　Objective　To investigate the correlation between mature T and nature killer(NK) cell lymphomas with EBV infection.Methods　The expression of EBER was detected using in situ hybridization method in 121 cases of mature T and nature killer cell lymphomas.Results　The expression of EBER was seen in 63.6%(77/121) of the cases. The EBER positive cells were tumor cells, and more than 30% of the tumor cells were EBER expression in extranodal mature T cell and NK cell lymphomas, while in nodal mature T cell and NK cell lymphomas, the EBER positive cells were less than 10%, the positive cells were large transform tumor cells or reactive B cells. The EBER expression rate of extranodal mature T cell and NK cell lymphomas (75.9%,60/79) was higher than that of nodal mature T cell and NK cell lymphomas(40.5%,17/42)（P<0.01）.The positive rate of EBER was correlated with histopathological subtypes and location of diseases (P<0.01). 98.0%(48/49) of extranodal NK/T cell lymphoma(ENKCL) were EBV infection and the EBER positive cells were more than 30%, 77.8%(7/9) of angioimmunoblastic T cell lymphoma(AITL) were EBV infection, and the EBER expression cells were some of reactive B cells, the positive cells were less than 10%,while most of the tumor cells were negative to EBER. 41.5%(17/41) of peripheral T cell lymphoma non specificity(PT,NOS),33.3%(2/6) enteropathy-associated T-cell lymphoma(EATL) and 18.2%(2/11) of anaplastic large cell lymphoma with ALK positive ALCL(ALK+) were EBV infection.Conclusion　EBV maybe play an important role on the development of extranodal mature T and nature killer cell lymphomas. Detecting the expression profile of EBER in mature T and nature killer cell lymphomas may be helpful to their diagnosis and therapy.]]> 2018/5/14 8:34:42 ZHOU Xiang-zhen, MO Xiang-lan,HUANG Zhen-lu,et al. 478true ［Abstract］　Objective　To explore the clinical effect of high speed grinding cut combined with bone cement filling in the treatment of giant cell tumor of the bone(GCTOB).Methods　Thirty-two cases of GCTOB were randomly divided into observation group and control group. Eighteen cases of the observation group were treated by high speed grinding cut combined with bone cement filling.Fourteen cases of the control group were treated by clearance of focal lesions combined with bone grafting.After operation Mankin judgment standard was used for evaluating limbs function.Results　The observation group was superior to the control group in recovery of limbs function (χ²=4.23,P<0.05).Conclusion　High-speed grinding cut combined with bone cement filling in the treatment of GCTOB is safe, so it can improves the post -operative limb function greatly.]]> 2018/5/14 8:34:42 ZENG Ye-long, ZHANG Wen-zuo, NING Shi-da 477true ［Abstract］　Objective　To compare the clinical application conditions between nasojejunal tube and feeding jejunostomy tube in early enteral nutrition of the postoperative patients with upper gastrointestinal cancer.Methods　Among 226 postoperative patients with upper gastrointestinal cancer who received early enteral nutrition,148 patients were placed nasojejunal tube and 78 patients were placed feeding jejunostomy tube.Results　In 226 postoperative patients, the effect were good after early enteral nutrition. But the incidence of adverse reactions in the patients placed feeding jejunostomy tube was lower than that in the patients placed nasojejunal tube(P<0.01).Conclusion　The early enteral nutrition by nasojejunal tube and feeding jejunostomy tube in the postoperative patients with upper gastrointestinal cancer can protect the gastrointestinal mucosal barrier, promote intestinal hormone secretion,prevent bacterial translocation and improve the immune capacity.But the incidence of adverse reactions in the patients placed feeding jejunostomy tube is lower than that in the patients placed nasojejunal tube.]]> 2018/5/14 8:34:42 SU Xiao-lin, XU Wang-yan 476true ［Abstract］　Objective　To explore the feasibility and efficacy of posterior three plane pedicle screws fixation system in the treatment of thoracolumbar fractures.Methods　From June 2008 to October 2010, 26 patients with thoracolumbar fractures were treated by posterior three plane pedicle screws fixation system for the reduction and fixation, preoperative and postoperative follow-up radiography was used for observing,the changes of vertebral body height, Cobb′s angle and internal fixator.Results　During 3～20 months follow-up, postoperative vertebral body height basically returned to normal, physiological curvature,vertebral body height and Cobb′s angle recovered satisfactorily, without obvious loss.Conclusion　Posterior three plane pedicle screws fixation system in the treatment of thoracolumbar fractures is helpful for rectifying protrusion deformity,maintaining correction effect and reducing the incidence of loose and rupture of internal fixator.It can make patient early activity, which is beneficial to the recovery.]]> 2018/5/14 8:34:42 DU Xin-li,LIU Ke-song,LI Wen-biao,et al. 475true ［Abstract］　Objective　To analyze the clinical characteristics of patients with mature ovarian teratoma who received laparoscopic treatment.Methods　The clinical data of 106 patients with mature ovarian teratoma who received laparoscopic surgery were analyzed retrospectively.Results　All of 106 patients received laparoscopic surgery successfully and had no serious complications. The accuracy of diagnosis by color doppler ultrasonography was 98.11%(104/106). The rupture of mature ovarian teratoma during laparoscopic surgery had no significant impact on the postoperative pregnant rate and the postoperative morbidity (P>0.05), while had significant impact on the volume of blood loss and the time of operation (P<0.05). Examination of the other ovary was performed during the operation in 25 patients, but no lesion was found. The examination of the other ovary during the operation had no significant impact on the postoperative pregnant rate of patients (P>0.05).Conclusion　Laparoscopic treatment of mature ovarian teratoma is a mature,safe and reliable technology. The rupture of mature ovarian teratoma during laparoscopic surgery had no significant impact on the postoperative pregnant rate and the postoperative morbidity. Examination of the other ovary during the operation had no significant impact on the postoperative pregnant rate. If the appearance of the other lateral ovary is normal, exploratory operation is unnecessary.]]> 2018/5/14 8:35:38 ZHOU Li-kai, LI Qiu-lan 474true ［Abstract］　Objective　To explore the clinical therapeutic effect of posterior pedicle screw fixation via injured vertebra in the treatment of thoracolumbar burst fractures.Methods　From February 2007 to November 2010, 51 patients with thoracolumbar burst fractures were retrospectively studied. Among which 33 were treated with the above method (Group 6 screws),and the other 18 were treated with traditional two-level fixation method beyond injured vertebra (Group 4 screws). Before and after surgery and at follow up,all patients were evaluated with X-ray for anterior height of injured vertebra and Cobb′s angle. Following period were 3～24 months (mean 13.5 months).Results　Pedicle screws were successfully implanted and horizontal rods were placed in three vertebra. The position and stability of screws were in good condition. No incision infection happened and no spinal nerve symptoms got wrose in all patients. Recovery of Cobb′s angle and height of the injured vertebra were satisfactory. After 1 year of operation, the effect of Group 6 screws was better that of group 4 screws (P=0.002).Conclusion　Posterior pedicle screw fixation via injured vertebra in the treatment of thoracolumbar burst fractures can enhance the stability of fracture fixation effectively, restore and maintain the height of injured vertebra, correct the kyphosis. Its therapeutic effect is better.]]> 2018/5/14 8:35:38 HUA Yun-yi, HUANG Wei-jie, LUO Tao 473true ［Abstract］　Objective　To analyze and summarize the clinical and pathological features of metastatic ovarian tumors.Methods　A total of 37 cases of metastatic ovarian tumors that has treated in the Guangxi Zhuang Autonomous Region People′s Hospital, in the past six years, were reviewed to analyze the clinical data, the morphological and immunohistological features of the metastatic ovarian tumor.Results　The age of onset was from 15 to 69 years, with a mean age of 43.6 years. Clinical manifestations are non-specific, the adnexal mass with ascites was the main feature, accounting for 45.9%(17/37), and cancer cell detection rate was 64.7%(11/17). Tumor of both ovaries was found in 24 cases, accounting for 64.9%(24/37). Twenty-two cases of clinical ovarian tumors (being considered as the primary tumor) admitted to hospital,with clinical misdiagnosis rate as high as 59.5%(22/37). Tumors form mainly presented as the structure of signet ring cell carcinoma and adenocarcinoma. Source areas: gastrointestinal tumors accounted for 75.6%, endometrial adenocarcinoma accounted for 16.2%.Conclusion　Metastatic ovarian tumor was mainly originated from gastrointestinal tumors.Its the final diagnosis depends on pathological features and clinical data.For the female with history of gastrointestinal cancer surgery,a close follow-up must be performed,alerting to the occurrence of ovarian metastasis.]]> 2018/5/14 8:35:38 TAN Jing-lang,WEI Hai-ming 472true ［Abstract］　Objective　To investigate the value of combined determination of a lot of biochemical index in early diagnosis of hypertensive renal damage. Methods　Ninety-eight hypertension patients were divided into A group and B group. Hypertension patients without complication were used as group A (n=50), those with microalbuminuria were used as group B (n=48), and 56 healthy persons were used as control group. Scr, Cys-C, β₂-MG, N-acetyl-β-D-glucosaminidase (NAG) were measured respectively.Results　Scr had no significant difference among the three groups(P>0.05),and the levels of Cys-C, β₂-MG and NAG in group A and B was higher than those in control group(P<0.01), and the levels of Cys-C, β₂-MG and NAG in group B was higher than those in group A (P<0.01).The positive diagnosis rate of combined determination of Cys-C、β₂-MG and NAG in early diagnosis of hypertensive renal damage can reach 69.3%(68/98), which was higher than Cys-C 36.7%(36/98), β₂-MG 28.5%(28/98) and NAG 33.6%(33/98) which was detected by single index(P<0.01).Conclusion　Combined determination of blood and urine can reflect hypertensive renal functional lesion early, and have high sensitivity and clinical significance in early diagnosis of hypertensive renal damage.]]> 2018/5/14 8:35:38 HE Dong-ming, FU Chun-hui, YAN Hua 471true ［Abstract］　Objective　To explore risk factors,prevention and operating technique of persistent ectopic pregnancy(PEP) after conservative operation of tubal pregnancy under laparoscope.Methods　The clinical data of 635 cases who were treated with conservative operation of tubal pregnancy under laparoscope in our hospital from January 2004 to December 2010 was retrospectively analyzed.Results　The PEP rate was significantiy related to the time of the cessation of menstruation and the diameter of ectopic mass,the level of HCG in blood before operation,operation methods,the medical history of tubal pregnancy,the PEP rate of patients undewent ovarian luteal surgery during conservative operation of tubal pregnancy under laparoscope and so on(P<0.05 or <0.01),and was not related to intraperitoneal bleeding loss volume and pelvic adherence.Conclusion　Realizing the risk factors of PEP,controlling the operation indication restrictedly and investigating operating technique can inhibit the occurrence of PEP effectively.]]> 2018/5/14 8:35:38 CHEN Guang-li, XU You-xian, SUN Jing-xue 470true ［Abstract］　Objective　To study the correlation between ultrasonographic features and renal pathological typing of the primary chronic glomerulonephritis. Methods　The comparison between features of Color doppler flow imaging (CDFI) and renal pathological typing in 212 cases of the primary chronic glomerulonephritis was performed. Results　There were different ultrasonographic features and renal pathological typing in 212 cases of the primary chronic glomerulonephritis. CDFI showed no abnormalities in 59 cases whose pathological type was minimal change glomerulonephritis in 41 cases, IgA nephropathy in 8 cases, mesangial proliferative glomerulonephritis in 4 cases,membranous nephropathy in 3 cases, existence of variety pathological type in 3 cases. CDFI showed double renal parenchymal damage in 98 cases, whose pathological type was IgA nephropathy in 41 cases, membranous nephropathy in 14 cases, mesangial proliferative glomerulonephritis in 12 cases, existence of variety of pathological type indirectly judging 31 cases. CDFI showed double renal chronic damage and atrophy in 55 cases.Whose pathological type was sclerosis nephritis. Conclusion　Observation of renal two-dimensional imaging and CDFI could help to indirectly judging renal pathological typing of chronic nephritis and prognosis.]]> 2018/5/21 9:01:32 ZHANG Zong-hua,GAO Ping 469true ［Abstract］　Objective　To compare the effect between the modified posterolateral mini-incision approach and the traditional post-lateral approach in the total hip arthroplasty, and study the advantages and limitations of the minimal incision surgery in clinical application.Methods　Forty-eight patients received total hip arthroplasty were randomly divided into two groups, 24 cases using the modified posterolateral mini-incision approach in total hip arthooplasty(minimal incision group), and other 24 cases using the traditional lateral approach(contiol group). The patients′ sex, age, weight, operative time, intraoperative blood loss and postoperative drainage volume, incision length, intraoperative and postoperative fractures, the initial time of postoperative functional exercises time, postoperativeHarris score, postoperative hip dislocation and other complications were recordecl. The follow-up time lasted 3 to 18 months, with an average of 12 months.Results　The intraoperative and postoperative blood loss, incision length and the initial time of postoperative functional exercise in the mini-incision control group were significantly less than those in the control group （P<0.05）. There were no significant difference in the intraoperative and postoperative fractures,postoperative hip dislocation, postoperative Harris score and postoperative complications.Conclusion　The modified posterolateral mini-incision approach in total hip arthroplasty can shorten the operation time and reduce the risk of postoperative complications and improper prosthetic position. In the early postoperative stages, the advantages of mini-incision approach were small surgical trauma, less blood loss and early joint exercise.]]> 2018/5/21 9:01:32 HUANG Chung-chao 468true ［Abstract］　Objective　To investigate the relationship between the changes of ambulatory blood pressure and urinary albumin excretion rate in patients with mild pregnancy hypertension syndrome.Methods　Sixty-eight patients with mild pregnancy hypertension syndrome and 76 normal late pregnancy women were selected. In two groups, the 24 h dynamic blood pressure were monitored, simultaneously monitoring the urine albumin excretion rate for analysis of the correlation between the two indexes. Results　The 24 h systolic or diastolic blood pressure and mean blood pressure load in mild pregnancy hypertension group were higher than those in normal pregnancy group(all P<0.05).The mean diurnal blood pressure in mild pregnancy hypertension group was (8.2±2.6)%. And the mean diurnal blood pressure in normal pregnancy group was (16.2±2.4)%, there was a significant difference between two groups (P<0.05). The urinary albumin in mild pregnancy hypertension group was (50.6±32.4)mg/d, and higher than that in normal pregnancy group［(15.1±9.5)mg/d］, the difference was statistically significant (P<0.05).In patients with mild pregnancy hypertension syndrome,there was a positive correlation between the change of 24 h ambulatory blood pressure and urinary albumin excretion rate.Conclusion　In patients with mild pregnancy hypertension syndrome the change of pressure circadian disappeared,and there is close correlation between This change and early kidney damage; during pregnancy the monitoring of 24 h ambulatory blood pressure and urine albumin excretion rate has an important clinical significance.]]> 2018/5/21 9:01:32 WANG Xiao-ping 467true ［Abstract］　Objective　To investigate the incidence of awareness during general light anesthesia in patients undergoing gynecologic laparoscopic surgery and analyze the risk factors of awareness in operation.Methods　A total of 900 patients with benign adnexal neoplasm undergoing laparoscopic surgery under general light anesthesia were surveyed by questionnaire on the first and second day after surgery, and the incidence of awareness during operation was counted. The sensory perception was recorded in patients having awareness in operation. The factors that probably influenced awareness were analyzed with the method of multiple regression analysis. Results　Eleven patients (1.22%) were identified as awareness. Incidence of awareness was associated with age, circulating state of the patients, premature withdrawal and emergency surgery, did not relate with weight.Conclusion　The high risk factors of intraoperative awareness are associated with age, circulating state of the patients, premature withdrawal and emergency surgery. Reasonable depth of anesthesia monitoring is a fundamental measure to prevent intraoperative awareness.]]> 2018/5/21 9:01:32 FENG Dan-feng, JIN Ri-nan 466true ［Abstract］　Objective　To investigate the short term effect of 96 hours′ sequential chemotherapy of cisplatin and 5 - fluorouracil program by catherizing via uterine artery for locally advanced cervical cancer.Methods　Twenty-nine patients with cervical cancer atⅠb₂ ～ Ⅲb stage (tumor diameter ≥ 4 cm) received bilateral uterine arterial infusion of DDP 70 mg/m², while the uterine artery of in the side of light of disease was embolized, and the trunk uterine artery in the side of severe disease was preserved, and 96 hours′ continuous chemotherapy of 5-fluorouracil 4 000 mg/m² was performed, efficacy and adverse reactions were observed.Results　Among 29 patients,complete remission were found in 18 patients, partial remission in 8 patients, the total effective rate was 89.6%. All patients had varying degrees of gastrointestinal reactions,2 patients had mild elevated alanine aminotransferase (40～80 U/L), 6 patients Ⅰ～Ⅱ° bone marrow suppression. Genital skin irritation peeling was found in one patient, which was relieved after symptomatic treatment. No puncture infection, hematoma, lower extremity thrombosis and renal dysfunction were found.Conclusion　Uterine artery embolization plus the sequential chemotherapy of cisplatin combined with 5 - fluorouracil chemotherapy program in the treatment of patients with locally advanced cervical cancer is safe and effective.]]> 2018/5/21 9:01:32 LIANG Gui-ling,MI Jian-fen,LIANG Ning-an 465true ［Abstract］　Objective　To study the characteristics of multiple myeloma (MM) in ^99mTc-MDP bone scanning, investigating the applied value of ^99mTc-MDP bone scanning in diagnosis of the MM.Methods　The findings of 42 patients with MM who underwent ^99mTc-MDP bone scanning were analyzed. Results　^99mTc-MDP bone scanning of 34 patients were abnormal in the 42 patients with MM, the masculine rate was 80.5%,lesions were multiple. Most of imaging showed the focal areas of increased uptake. Little of imaging showed the co-existence of focal areas of increased uptake and decreased uptake. Most of the lesions were detected in rib, spine, pelvis and limbs. Multiple uptake increase like a dot or string of pearls was often seen in ribs. Most of the lesions in spine showed as flat “hot” areas. The lesions in pelvis and spine showed as doughnut sign. The lesions in skull showed the extensive areas of increased uptake like a “cap”.Conclusion　There are some characteristics in ^99mTc-MDP bone scanning with MM. ^99mTc-MDP bone scanning can be considered as one of routine examination for detecting bone lesions for patients with MM.]]> 2018/5/21 9:01:32 TAN Xiao-dan,PENG Sheng-mei, WEI Zhi-xiao,et al. 464true ［Abstract］　Objective　To evaluate the clinical effect of the combined treatment for lower extremity deep venous thrombosis (LEDVT). Methods　Clinical data of 62 cases of LEDVT after combined treatment were analyzed retrospectively. The treatment included placement of inferior vena cava filters, operation, anticoagulant, antiplatelet and wearing forced socks and so on.Results　Forty-three cases (69.35%) were cured, 15 cases (24.19%) were effective, 4 cases (6.45%) were ineffective. No death case was found.The total effective rate was 93%. Conclusion　The combined treatment for LEDVT has better clinical effect and shorten the course of the disease. General managment should be performed in treating patients with patients with LEDVT.]]> 2018/5/28 8:15:14 SUN Yu-gui, HUANG Bao-tang,YU Jin 463true ［Abstract］　Objective　To observe the effects of atorvastatin calcium on blood lipid level of patients with transient ischemic attack but average blood lipid level and its clinical efficacy.Methods　Seventy-nine patients with transient ischemic attack but average blood lipid level were randomly assigned to treatment group (n=40) and control group (n=39).Treatment group received atorvastatin calcium with conventional treatment for six months,the control group received only conventional treatment. The blood lipid levels before and after treatment in both groups were determined.The cerebral vascular incident rates were compared within six months between two groups.Results　The cerebral vascular incident rates were 12.5% and 30.8% for treatment group and control group respectively,there was significant difference between the two groups (P<0.05).Before treatment there was no significant difference in blood lipid levels between two groups (P all >0.05).In treatment group after treatment,the levels of blood cholesterol,triglyceride and low-density lipoprotein significantly decreased and high-density lipoprotein significantly increased (P<0.05).In control group, there was no significant difference in blood lipid levels before and after treatment (P>0.05),there was significant difference in blood lipid levels between two groups after treatment(P all<0.01).Conclusion　Atorvastatin calcium can not only adjust blood lipids levels,but has remarkable effect for the secondary prevention of transient ischemic attack.It can reduce the incidence of stroke.]]> 2018/5/28 8:15:14 REN Jian-gang,WANG Hai-he,SHANG Yun,et al. 462true ［Abstract］　Objective　To investigate the curative effect of coronary heart disease with arrhythmia treated with wensinkeli combined with metoprolol.Methods　One hundrend and sixty patients with coronary heart disease complicated with arrhythmia treated in our hospital from June 2008 to June 2011 were randomly divided into observation group(n=80) and control group(n=80). The observation group were treated with wenxinkeli combined with metoprolol, while the control group were treated with propafenone. The clinical effects of the two groups were observed, compared and then analyzed.Results　The curative effects and total effective rate of the observation group were higher than those of the control group (P<0.01).Conclusion　Wenxinkeli combined with metoprolol has a good clinical effect for treatment of coronary heart disease with arrhythmia.The side effect and complications are low. However, in clinical use of drugs we should take the patients′ heart function,complications and the actual situation into account, emphasizing the individual and avoiding drug abuse.]]> 2018/5/28 8:15:14 HUANG Jiang-xin 461true ［Abstract］　Objective　To study the incidence, constituent ratio and microbiology of nosocomial infections (NI) in the People′s Hospital of Guangxi Zhuang Autonomous Region during 2001～2010.Methods　Information on NI was collected prospectively by active surveillance.Results　The overall incidence of NI was 3.39%,with a trend of increase during the study period. A significant increase in NI incidence was recorded during 2007～2008（P<0.01）. NI was most commonly found in the lower respiratory tract, followed by urinary tract, digestive tract, upper respiratory tract, skin and soft tissue. Though a significant decrease in NI incidence of respiratory system was recorded during the study period (P<0.01), the constituent ratio of lower respiratory tract infection showed an increase from 27.9% to 43.18%. A significant increase was recorded in NI incidence of urinary system, hematological system, abdomen and digestive system, and surgical sites(P<0.01). The NI incidence was higher in departments of neurosurgery,gerontology, hematology and oncology than other hospital departments except the intensive care unit. Acinetobacter, Candida albicans and other fungi, Pseudomonad, Escherichia coli, Klebsiella and Staphylococcus aureus were the most frequently isolated infectious organisms.Conclusion　We have identified the most common sites, departments and organisms involved in NI, which will facilitate effective monitoring and focused intervention to reduce NI in a large provincial hospital.]]> 2018/5/28 8:17:42 LI Yuan-hui,CHEN Jie-yu,RU Jian,et al. 460true ［Abstract］　Objective　To study the relationship between serum calciumion concentration, the progress of labor and postpartum hemorrhage.Methods　In this study, 1348 normal puerperas who was natural childbirth were selected, and according to the normal calciumion concentration (2.1～2.6 mmol/L) in our hospital,they were divided into low calcium group (n=502), normal calcium group (n=721) and high calcium group (n=125). The differences in the time of second and third stage of labor, the incidence of uterine atony, postpartum hemorrhage etc between the three groups were compared.Results　Compared with the last two groups, the low calcium group had a longer stage of labor process, more amount of bleeding in postpartum hemorrhage, a higher incidence of uterine atony and postpartum hemorrhage. (all P<0.01).Conclusion　In order to prevent and reduce postpartum hemorrhage, puerpera′s calcium supplementation is necessary.]]> 2018/5/28 8:17:42 DONG Yong-rui, WANG Yan 459true ［Abstract］　Objective　To explore the correlation between clinical features and etiology in the patients with acute viral encephalitis (AVE).Methods　Two hundred and twenty patients with AVE treated in our hospital from January 1991 to December 2005 were retrospectively analyzed.Results　The shortest follow-up time was 150 days and the longest was 18 months. Thirteen patients failed to be followed up, the lost rate was 5.9% among 220 patients.One hundred and seventy-nine patients in the ≤14 age group; 41 patients in the ≥15 age group. In the blood and CSF of 220 patients AVE associated specific antibodies IgM were detected. The results showed HSV-1 positive in 146 patients, PXV positive in 21 patients, CSV-A/B positive in 19 patients, VZV positive in 12 patients, CMV positive in 10 patients, JEV positive in 7 patients and EB positive in 5 patients. The total effective rate was 90.46%,the mortality rate was 9.55%.Their prognosis were good after being treated in time.Conclusion　Detection of serum and CSF are helpful in diagnosis of the etiology of AVE.And early use of effective antiviral drugs significantly improve the prognosis.]]> 2018/5/28 8:17:42 LUO Yong-jian,LI Lv-li,LIN Xin-jing,et al. 458true ［Abstract］　Objective　To explore the effects of microsurgical treatment of acoustic neuroma in order to improve the of effects of treatment and patients′ quality of life.Methods　Fifty patients with acoustic neuroma were selected and given microsurgery via suboccipital-retro internal auditory canal approach. The therapeutic effects were analyzed.Results　Total tumor removal rate was 84.00%, The facial nerve anatomy retention rate was 80.00%. Six months after treatment the facial nerve function at Ⅰ～Ⅱ level accounted for 64.00% and the patients′quality of life were markedly improved compared with preoperative results (P<0.01).Conclusion　The effects of microsurgery in the treatment of acoustic neuroma is significant. It can significantly improve the total tumor removal rate, protect the facial nerve and better improve patient′s quality of life.]]> 2018/5/28 8:17:42 ZHANG Ji-yuan 457true ［Abstract］　Objective　To observe the clinical effects of misoprostol combined with indomethacin suppository in artificial abortion.Methods　One hundred and eighty early pregnant women were randomly divided into 3 groups. Group A (n=60) was administered oral misoprostol 0.6 mg 3 hours before operation and placed indomethacin suppository 100 mg in rectum 30 minutes before operation. Group B (n=60) received cervical injection with 1% 6 ml of lidocaine. Group C (n=60) did not take any intervention of drugs. The analgesic effect, conditions of Miyaguchi relaxation, incidence of artificial abortion syndrome, operating time,intraoperative blood loss and so on were observed.Results　Application of misoprostol combined with indometacin suppository in artificial abortion has better analgesic effect, higher full softening of the cervix, shorter surgery times, lower incidence of artificial abortion syndrome compared with group B and group C (all P<0.05),but there were no significant statistical difference in intraoperative blood loss between three groups (P>0.05).Conclusion　The application of misoprostol combined with indomethacin suppository in artificial abortions has the advantages of better cervic dilation,better analgesic effects, less side-effects and so on and is worthy of clinical promotion.]]> 2018/5/28 8:17:42 QIN Chun-hua 456true ［Abstract］　Objective　To explore the value of serum soluble triggering receptor expressed on myeloid cell-1(sTREM-1) in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease(AECOPD) patients with lung bacterial infection.Methods　The sTREM-1 level was detected by ELISA method and the further relevant analysis between sTREM-1 level and clinical lung infection score (CPIS) was performed.Results　The level of sTREM-1 in bacterial infection group was significantly higher than that in no bacterial infections group (P<0.05). According to the ROC curves of sTREM-1, AUC was 0. 930, 95%CI ranged from 0.840 to 1.020, the efficiency of diagnosis was prominent. And level of sTREM-1 had of the positive correlation with CPIS score (r=0.246, P<0.05).Conclusion　The early determination of the level of sTREM-1 has certain value in diagnose of AECOPD patients with pulmonary bacteria infection, and provide positive reference for evaluating severity of illness or infection.]]> 2018/6/4 8:29:26 CHEN Hui-peng 455true ［Abstract］　Objective　To observe effects of shenyankangfu tablet comibined with valsartan in treatment of patients with primary nephrotic syndrome(PNS). Methods　Eighty-five patients with PNS were randomly divided into control group(n=40) and treatment group(n=45). All the patients received lowering blood-lipid drugs, anticoagulation therapy and dose of valsartan was 80 mg one time per day, and the treatment group received shenyankanfu tablet on the basis of above treatment.Dose of shenyankangfu tablet was 2.4 g three times per day. The course of treatment was 12 weeks, 24 hour urinary protein, serum creatinine,albumin,glycerin trilaurate,total cholesterol were determined before and after treatment.Results　After treatment 24 h urinary protein, albumin, triglyceride,total cholesterol in two groups were ameliorated.The treatment group is superior to the control group in the amelioration of above indexes (P<0.05).Conclusion　Treatments of shenyankangfu tablet comibined with valsartan in patients with PNS can ameliorated the condition of hemorbeology,reduce proteinuria and elevate serum albumin and is worth a wide clinical application.]]> 2018/6/4 8:29:26 SHE Ning-lan, SHU Ying,QUAN Da-yong,et al. 454true ［Abstract］　Objective　To observe the effects of prostaglandin E1(PGE1) in the treatment of 35 diabetic patients with diabetic nephropathy stageⅢ.Methods　Fasting blood-glucose（FBG）,2-hour postprandial blood glucose （PBG2h）,serum creatinine,blood pressure, 24-hour urinary protein(UPRO),24-hour microalbuminuria(UMALB), adverse reaction were observed after drip infusion of PGE1 for 2 weeks.Results　As compared with pre-treatment,after treatment,24-hour urinary protein,24-hour microalbuminuria were reduced（P<0.01）,while there was no significant difference in the levels of FBG,PBG, systolic blood pressure （SBP）, diastolic blood pressure （DBP ）and serum creatinine（P>0.05）.And there were no skin rash, vasculitis, abnormal liver function and other adverse reaction in the patients during therapy.Conclusion　PGE1 in the treatment of diabetic nephropathy stage Ⅲ can reduce urinary albumin excretion rate, delay the deterioration of DN.]]> 2018/6/4 8:29:26 CHEN Hao,HUANG Xuan-geng,HE Yu-ling 453true ［Abstract］　Objective　To observe the effects and side effects in the treatment of cor pumonale with different daily dosages and amount of low molecular weight heparin(LMWH). Methods　One hundred and seven acute phase patients with chronic pulmonary heart disease treated in our hospital from April, 2007 to April,2011 were randomly divided into: group 1 (n=53) and group 2 (n=54). The patients in both groups received the following comprehensive treatments: continuous Oxygen therapy, anti-infection, anti-cough,phlegm removing, asthma relief, blood vessels enlargement, heart strengthening, diureses and the balance of water and electrolyte maintenance. On this basis, Once a day the hypodermic injection of LMWH 4250 U was added to the patients of group 1 while adding twice a day (once per 12 hours) the hypodermic injection of LMWH 4250 U to the patients of group 2. The effective rates and total effective rates for both groups were compared and blood flow of the patients after seven-day treatment were observed. Results　After using LMWH in the treatment,the effective rates and total effective rates for patients of both groups were similar, without obvious differences in statistics (P>0.05). In addition, none of the patients in both groups had a whole body bleeding symptom,but patients in group 2 had a higher bleeding rate in injection sites than patients in group 1. Conclusion　In the treatment of the acute phase patients with chronic pulmonary heart disease, no matter once a day or twice a day,if the patients are given the fixed dosage of LMWH, the curative effect is the same and the bleeding rate in injection sites obviously reduces.]]> 2018/6/4 8:29:26 ZHENG Shao-cheng,JIANG Hong-yan,BAI Ju,et al. 452true ［Abstract］　Objective　To observe the therapeutic effect of ganglioside in the treatment of neonatal bilirubin encephalopathy.Methods　Forty-two cases of neonatal bilirubin encephalopathy were randomly divided into the treatment group (22 cases) and control group (20 cases).The control group was treated with conventional treatment.On the conventional treatment，the treatment group was treated with ganglioside GM1 in the acute period, dose of 20 mg/d, 7 days for a course.The behavioral neurological assessment (NBNA) and therapeutic effect was determined during hospitalization.Results　The therapeutic effect in the treatment group was significantly better than that in the control group（P<0.05），and NBNA scores in the treatment was higher than that in the control group（P<0.01）.Conclusion　Ganglioside which treats the neonatal bilirubin encephalopathy can increase the effect of intervention.]]> 2018/6/4 8:29:26 YE Li-hua 451true ［Abstract］　Objective　To explore the efficacy of Acarbose combined with Humalog 25R in the treatment of patients with newly diagnosed type 2 diabetes. Methods　Eighty patients with newly diagnosed type 2 diabetes were randomly divided into treatment group (Acarbose combined with Humalog 25R) and control group (Acarbose combined with sulfonylurea drugs), 40 cases in each group, with 12 weeks of treatment. Before and after treatment, fasting blood glucose, 2-hour postprandial blood glucose, glycated hemoglobin, fasting C-peptide, 2-hour postprandial C-peptide, blood glucose standard time, the incidence of hypoglycemia were measured and compared.Results　Compared with control group, in the treatment group, the incidence of hypoglycemia was lower (P<0.05), the glycosylated hemoglobin decreased significantly (P <0.01), and the β-cell function improved significantly (P<0.05). Conclusion　Acarbose combined with Humalog 25R is an ideal treatment option for patients with newly diagnosed type 2 diabetes.]]> 2018/6/4 8:30:03 ZHAO Yi-yu 450true ［Abstract］　Objective　To understand the mycoplasma infection in the urogenital tract and the sensitivity of different antibiotics.Methods　The culture, identification and susceptibility integration kit was used for testing the urogenital tract secretions from 26 060 cases of suspected urogenital tract infection. Results　Mycoplasma infections were detected in 10 481 cases, the positive rate was 40.22%, including Ureaplasma urealyticum(Uu) infection in 9 366 cases (89.36%), Mycoplasma hominis(Mh) infection in 109 cases(1.04%), Uu and Mh mixed infection in 1 006 cases(9.60%). The results of drug susceptibility test showed: Uu infection, Uu and Mh mixed infection were all sensitive to josamycin, doxycycline and minocycline. The resistance rates of guinolones and macrolides were declining. Uu and Mh mixed infection showed broader resistance spectrum and higher resistance rate.Conclusion　Uu is the major mycoplasma for urinary tract infection, Uu and Mh mixed infection will increase drug resistance. Josamycin, doxycycline and minocycline can be the preferred choices for treatment of mycoplasma infection.]]> 2018/6/4 8:30:03 ZHOU Ying, QIN Gui-fang，NONG Sheng-zhou, et al. 449true ［Abstract］　Objective　To study the differential diagnosis value of CT perfusion in patients with hepatic cirrhosis.Methods　Twenty patients with hepatic cirrhosis and 15 volunteers underwent CT perfusion for detection of haemodynamics. Seven patients with hepatic cirrhosis belonged to cirrhosis group 1（Child-Pugh A），13 patients with hepatic cirrhosis belonged to cirrhosis group 2 （9 patients with hepatic cirrhosis were Child-Pugh B and the other 4 were Child-Pugh C）. Taking the liver dynamic enhanced steep slope(SS) curve by CT perfusion, and the type of curve was analyzed. The perfusion curves of hepatic parenchyma were separated into two part of arterial phase and venous phase according to the TTP of spleen, the max slope ratio of arterial phase and venous phase was calculated, signed to SSr, then SSr were compared between the 3 groups.Results　（1）the type of SS curve was different between the 3 groups (P<0.01); (2)the SSr of cirrhosis groups were higher than that of normal group, but the difference was not significant between cirrhosis group 1 and normal group (P>0.05), but the difference was significant between cirrhosis group 2 and normal group (P<0.01)；（3）the SSr of cirrhosis group 2 were significantly higher than cirrhosis group 1，the SSr of cirrhosis 2 was inversed ，the difference between two groups was significant （P<0.01）.Conclusion　The liver dynamic enhanced SS curve and SSr can reflect the blood flow of cirrhosis and the level of vascularization, be regarded as an indexes to evaluate the cirrhosis degree, and is a valuable important imaging in clinic.]]> 2018/6/4 8:30:03 WEI Hong-xing，PAN Qi-zhong, SU Guang-lin, et al. 448true ［Abstract］　Objective　To investigate the effect of glimepiride in insulin therapy instead of sulfonylureas treatment in patients with type 2 diabetes mellitus whose blood glucose was poorly controlled with adequate sulfonylureas.Methods　Eighty patients with type 2 diabetes mellitus whose blood glucose was poorly controlled with adequate sulfonylureas were treated with glimepiride at 3 mg,qd, for the previous 8 weeks instead of sulfonylureas.The patients whose blood glucose did not meet the blood glucose control substandard were treated by insulin therapy: twice daily subcutaneous injection of insulin aspart 30 U,and were randomly divided into two groups: continuation of glimepiride group(CONT) and discontinuation of glimepiride group(DIS).FPG,2hPG,HbA1c,BMI、insulin daily dose and number of hypoglycaemic episodes were observed.Results　FPG,2hPG of two groups both declined dramaticly at the 28th week and the 48th week. HbA1c values significantly declined from （9.2±1.1）% at the 8th week to （7.9±1.0）% at the 28th week in the CONT group,and furtherly declined to（7.1±0.6）% at the 48th week. HbA1c values declined from（9.1±1.0）% to（8.3±0.9）% in the DIS group accordingly,and were（8.4±1.1）% at the 48th week. The insulin daily dose used in the CONT group was much less than that in the DIS group at the end of the study,（0.21±0.12）U/(kg·d） and（0.34±0.13）U/（kg·d）, respectively.The number of hypoglycaemic episodes was 9(CONT group) and 7(DIS group) respectively during the treatment.The difference was not statistically significant. No severe hypoglycaemic episode was observed in both groups.Conclusion　Continuation of glimepiride during insulin therapy instead of sulfonylureas treatment can control glucose more effectively with less insulin daily dose,without increased hypoglycaemic risk,compared to discontinuation of glimepride.]]> 2018/6/4 8:30:03 XU Wen-jian,LIU Guo-feng,WANG Xu-tao,et al. 447true ［Abstract］　Objective　To explore the significance of emergency early trachea cannula and mechanical ventilation in the treatment of respiratory failure due to organophosphate poisoning.Methods　Sixty-four patients with the respiratory failure due to acute ganophosphate poisoning were divided in two groups according to breathing indicatiors of blood analysis.The conventional intubation group (30 patients) was treated by conventional method. The early intubation group (34 patients) was treated by trachea cannula and mechanical ventilation. The results of blood analysis, changes of heart rate,therapeutic effect before and after treatment between two groups were compared.Results　The arterial oxygen tension (PaO₂), oxygen saturation (SaO₂ ) in the conventional intubation group was significantly lower than those in the early intubation group (P<0.05).There were statistically significant difference in PaO₂, partial pressure of carbon dioxide (PaCO₂), SaO₂ and HR differences before and after treatment between two groups （P<0.05）.The cure rate in early intubation group was significantly higher than that in the conventional intubation group (P<0.01). Conclusion　Emergency early trachea cannula machanical ventilation can obviously raise the rescure success rate of respiratory failure due to ganophosphate poisoning.]]> 2018/6/22 16:33:56 CHEN Tian-shan,LIANG Bo,HUANG Wei 446true ［Abstract］　Objective　To discuss the clinical features and the treatment of newborns with pneumonia.Methods　Ninety-six newborns with infectious pneumonia were selected to observe the clinical features;and their imaging examination and laboratory examination were performed at the same time;and same therapy was carried out based on the differences of pathogens.Results　Eighty-six cases were cured in 96 newborns,cure rate was 89.6%;7 cases recovered without continuing treatment;3 acute cases died from abandoning treatment.Conclusion　Antibiotics should be chosen on the basis of drug sensitive test and the differences of pathogens in newborns, the ward regulation of sterilisation and isolation must be strictly observed in order to prevent drug resistance of pathogens and to benefit the treatment.]]> 2018/6/22 16:33:56 ZHANG Jian 445true ［Abstract］　Objective　To investigate the clinical effect of catheterization chemotherapy and embolization for liver metastasis from lung cancer.Methods　Forty-eight patients with liver metastasis from lung cancer randomly divided into two groups,the observation group of 24 patients and a control group of 24 patients. The observation group was treated by superselective catheterization and infusion of chemotherapy plus liquid iodized oil embolization. The control group was given conventional anticancer therapy.After treatment white blood cells, liver function, clinical symptoms and survival rate of change were observed.Results　Before treatment,the differences in leukopenia, liver function, clinical symptoms and tumor volume between two groups were not statistically significant (P>0.05). After treatment, the difference in above indexes between two groups were statistically significant (P<0.01). The survival studies showed that there were no statistically difference in the mortality rate in 3 and 5 month between two groups （P>0.05）, while that in 7 and 12 month in the observation group were lower than the control group （P<0.01）. Further study showed that most of the control group died within 7 months, the mortality rate was 83.3%, while the observation group was only 37.5%, there were statistically significant difference between two groups in both indexes (P<0.01).Conclusion　Hepatic arterial infusion chemotherapy and embolization for liver metastases from lung cancer have less side effects, and can obtain a more satisfactory clinical results.]]> 2018/6/22 16:33:56 HE Guang-hui, GAO Hong-sheng, CHEN Lu-qing,et al. 444true ［Abstract］　Objective　To investigate the inducing rash frequency of allergizing drugs of bullous epidermolytic necrotic drug eruption.Methods　Relevant cases from referential articles were reviewed, allergizing drugs were calculated, and the incidence rates of bullous epidermolytic necrotic drug eruption were calculated by collecting the incidence rates of adverse reactions caused by allergizing drugs.Results　There were 51 kinds of drugs that caused bullous epidermolytic necrotic drug eruption, among 176 positive cases, there were 69 cases related to 17 anti-infective drugs, 46 cases related to 6 neuropsychiatric drugs, 28 cases related to 4 antipyretic analgesics. 26 cases related to carbamazepine alone (an incidence rate of 5.04%), 18 cases related to aminopyrine (an incidence rate of 0.68%), 9 cases for each of phenobarbital and amoxicillin (incidence rates of 1.24% and 0.37% respectively).Conclusion　Anti-infective drugs, neuropsychiatric drugs, and antipyretic analgesics are common drugs that trigger bullous epidermolytic necrotic drug eruption, while carbamazepine, phenytoin sodium,allopurinol and paracetamol are high in incidence rate of causing drug eruption.]]> 2018/6/22 16:33:56 CHEN Yong-bin 443true ［Abstract］　Objective　To study the effects of Nd:YAG laser with different preoperative managements for after-cataract.Methods　Sixty-two cases (62 eyes) with after-cataract were divide into two groups and treated with Nd:YAG laser.Surface anaesthesia and contact mirror were used before taking laser treatment under preset lens in group A;laser treatment was directly taken without management in group B. The follow up time was 6 to 12 months.Results　Visual acuity improved at different levels after Nd: YAG laser treatment in 62 eyes of 62 cases,the improved rate of visual acuity was 100%. There were significant differences of visual acuity in A group and for group B between re-operation and post-operation (P all<0.01). The time of laser treatment in group B （4.62±1.54）minutes was shorter than that in group A（7.42 ±1.85） minutes,there was signifacant difference between the two group (P<0.01). No serous complication was found in both two group postoperatively.Conclusion　Nd:YAG laser without surface anaesthesi and contact mirror is a simple and reliable treatment for after-cataract too.]]> 2018/4/8 15:34:47 XIE Wei, YAO Shu-ling, ZHANG Yan, et al. 442true ［Abstract］　Objective　To investigate the clinical effect of integrated Chinese and western medicine in treating patients with tibia and fibula fracture.Methods　Seventy-seven patients with tibia and fibula fracture were selected and divided into 2 groups randomly.Of them 35 patients in control group were treated by closed reduction andinterlocking intramedullary nailfixation, and other 42 patients in observation group were given Chinese medicine decoction orally on the basic treatment of control group. The time of treatment and recovery, complications and clinical effect of two groups were compared.Results　The total effective rate and complication rate of observation group were 95.2% and 16.7% respectively, significantly better than that of control group(P<0.05), and the time of callus occurrence, fracture healing time and hospitalization time were (37.1±3.8)d,( 133.5±9.4)d and(16.7±2.9)d respectively, significantly lower than that of control group(P<0.05).Conclusion　The clinical effect of integrated Chinese and western medicine in treating tibia and fibula fracture is significantly better than that of single method, it can accelerate the healing rate and lower the complication rate, and deserve to be promoted in clinical pratice.]]> 2018/4/8 15:34:47 HUANG Zhi-ming 441true ［Abstract］　Objective　To understand the clinical situation of general pediatric inpatients in Guigang Maternal and Child Health Hospital,in order to provide a scientific basis for the treatment and preventive health care of childhood diseases in the region.Methods　The electronic medical records of 1 788 discharged pediatric inpatients from January 1,2011 to December 30 were analyzed retrospectively.Results　In hospitalized children male was more than female;0～12 months′ baby was most, a total of 1 285 cases,accounting for 71.87% of cases;the top five diseases in order were acute bronchitis, pneumonia, infantile enteritis,acute upper respiratory tract infection,Mediterranean anemia; the average hospitalization time was 5.23 days; seasonal distribution was not obvious, in spring, summer, autumn, winter patients′number were 483 cases (27.01%),476 cases (26.62%),359 cases (20.08%),470 cases (26.29%) respectively; according to discharged month,the top three place in order were March (12.64%), April (12.08%), December (10.46%); the cure rate was 54.19%, the improvement rate was 36.30%, mortality was 0.11%, the total effective rate of treatment was 90.49%.Conclusion　Clinical features of paediatric inpatients are (1)male more than female;(2)the baby within 12 months is in the majority;(3)infectious diseases of respiratory and digestive system are common;(4)hospitalization time is short;(5)season distribution is not obvious but in March, April and December there was more number in discharged patients, so it should be paid attention by clinicians and hospital managers.]]> 2018/4/8 15:34:47 DUAN Jie-hua 440true ［Abstract］　Objective　To improve knowledge of pulmonary sclerosing hemangioma（PSH）and investigate the CT findings correlated with it′s pathologic changes.Methods　The clinical date and CT date in 9 patients with PSH proved by pathology were retrospectively analyzed.Results　The disease mainly occurred in female patients 40 years old;on CT, the lesion presented as 1～3 cm in diameter well-defined, round and oval shaped mass or nodule；a homogeneous soft-tissue mass on unenhanced CT,calcification was found in some lesions;homogeneous or heterogeneous enhancement after contrast administration;on delayed phase scans, some of them demonstrated late enhancement；the seemingly characteristics：air-trapping zone, vessels at its periphery.Conclusion　Although the final diagnosis of PSH depends on pathology, CT is helpful to its diagnosis and differential diagnosis.]]> 2018/4/8 15:34:47 ZHU Yong,WANG Li 439true ［Abstract］　Objective　To investigate the diagnosis value of color Doppler ultrasound for breast cancer with vessel cancer embolus around carcinoma.Methods　A retrospective analysis of 101 patients with breast cancer was performed， of them, 43 patients with breast cancer complicated by cancer embolus around carcinoma while the other 58 patients hadn′t cancer embolus around carcinoma. Two-dimensional ultrasound images and color Doppler flow imaging were compared between two groups.Results　There were statistically significant difference in patient′s age, tumor size, histological grade, axillaries lymph node metastasis, color Doppler ultrasonic flow grade between two groups（P<0.05）.The younger patients，with larger mass size， higher histopathology grading, auxiliary′s lymph nodes metastasis and higher ultrasonic flow grade， were more prone to occurring of peritumoral vascular invasion.Conclusion　The peritumoral vascular invasion of breast carcinoma had great relativity with size of primary mass, age of the patients, the classification of histopathology, ultrasonic flow grade and the metastasis of auxiliary′s lymph nodes. The color Doppler ultrasound had important clinical significance for breast cancer with vessel cancer embolus around carcinoma.]]> 2018/4/11 8:05:21 HUANG Xiang-hong 438true ［Abstract］　Objective　To observe the clinical findings and therapy procedure of intractable right ventricular heart failure patients caused by chronic pulmonary heart disease combining pulmonary thromboembolism.Methods　Thirty-six intractable right ventricular heart failure patients caused by chronic pulmonary heart disease were obseved,all were confirmed by CTPA to have pulmonary thromboembolism,25 of the patients had dynamic obstacles blood flow and received therapy of anticoagulation and thrombolysis,the other 11 only received anti- coagulation.Results　After therapy,33 patients bettered,3 died of respiratory failure or intractable right ventricular heart failure.Conclusion　Pulmonary heart disease combining pulmonary thromboembolism can often cause intractable right ventricular heart failure,the patients don′t have classic clinical findings,the symptoms can be covered by basic disease,the disease can often be misdiagnosed and should be paid more attention.]]> 2018/4/11 8:05:21 YANG Hong-ji 437true ［Abstract］　Objective　To explore the effect of fallopian tube recanalization (FTR) in combination with laparoscopic treatment on tubal infertility.Methods　A retrospective analysis of the outcome of 39 patients who have received FTR in combination with laparoscopic treatment was performed. The chosen study population consisted of patients who presented with proximal tubal obstruction with either side distal tubal obstruction and was treated between July 2001 and December 2008.Results　In a total of 39 patients with 76 obstructed fallopian tubes, giving a success rate for the procedure of 93.42%(71/76). Three-month follow-up salpingography revealed a re-obstruction rate of 11.27%(8/71). Two-year follow up revealed a spontaneous pregnancy rate of 33.33%(13/39).Conclusion　FTR in combination with laparoscopic treatment is very effective in tubal infertility. FTR and laparoscopic treatment have complementary strengths and effectively improve the recan-alization rate, so it can be considered an effective tool for tubal infertility.]]> 2018/4/11 8:05:21 REN Xiao-qing, XUE Yuan-ling 436true ［Abstract］　Objective　To explore the effect of immediate use of drospirenone-ethinylestradiol tablets after abortion in women undergoing artificilal abortion.Methods　A total of 300 women who undergoing artificial abortion were divided into two groups.In observation group,150 women took drospirenone-ethinylestradiol tablets immediately after abortion and in control group 150 women took other methods.The volume and duration of vaginal bleeding,intrauterine adhesions and menstruation were observed.Results　Compared with control group,the volume of vaginal bleeding was less,the time of vaginal bleeding and the recovery were shorter after treatment in observation group(P all <0.01).There was no intrauterine adhesion in observation group.Conclusion　Drospirenone-ethinylestradiol tablets are safe and effective in women when taken immediately after artificial abortion as an option of contraception.This promotes the menstruation recovery and offers a good prevention in intrauterine adhesions.]]> 2018/4/11 8:05:21 XU Min 435true ［Abstract］　Objective　To study the value of combined detection of cystatin C and β₂-microglobulin(β₂-MG) in predicting early renal damage of children with Henoch-Schnlein purpura（HSP）.Methods　Forty-five children with HSP were selected. The particle enhanced transmission turbidimetric immunoassay was used for detecting serum cystatin (Cys C) and radio immunoassay for serum β₂-MG.The results were compared with those of healthy control group.Results　The levels of serum Cys C and β₂-MG in children with HSP were higher than those of healthy control group（P<0.01）. The positive rate of combined detection was obviously higher than that of single detection (P<0.01).Conclusion　Serum Cys-C and β₂-MG can be used as the detection indexes of early renal damage，and combined detection can improve the positive rate.]]> 2018/4/27 8:23:45 LIU Dong-li,FAN Shu-hong 434true ［Abstract］　Objective　To observe the curative effect and poisonous side reaction of paclitaxel(PTX) plus DDP combined with 3DCRT concurrently in the treatment of advanced esophageal carcinoma.Methods　Forty-five advanced esophageal carcinoma patients, both previously untreated and without distant metastasis were divided into two groups randomly. Twenty-two cases were in 3DCRT plus chemotherapy group (CRT). The other 23 cases were in 3DCRT group (RT). Both groups were applied 3DCRT during the treatment, 2 Gy/F, 1 F/d, 5 F/w, the total dose of esophageal carcinoma primary focus was 60～70 Gy. CRT group were given PTX plus DDP in the first day of radiotherapy, 3 weeks was one course, all together the treatment lasted for 2 or 3 courses.Results　The recent response rates of CRT group were 90.9%, that of RT group were 65.2%. There were significant differences between two groups （P<0.05). The 1,2,3-year survival rates of the CRT group were 63.6%，50%，36.4%, while the survival rates of the RT group were 47.8%，36.4%，8.6%. There were significant differences between two groups（P<0.05). The toxic effect in CRT group are more severe than that in RT group, all the patients can tolerate it.Conclusion　The effect of PTX plus DDP combined with 3DCRT concurrently in the treatment of advanced esophageal carcinoma is positive, and it can increase the long term survival rates. However,the toxic effect were increased ( all the patients can tolerate it).]]> 2018/4/27 8:23:45 WEI Liang-peng, HUANG Zeng-guang 433true ［Abstract］　Objective　To explore the clinical effect of continuous retrograde coronary sinus perfusion of autologous blood from oxygenation machine under middle hypothermia during double valve replacement plus maze procedure.Methods　All 27 patients underwent open heart surgery under hypothermic cardiopulmonary bypass. Nasopharyngeal temperature was dropped to the middle and low temperature (26～27 ℃) and was maintained intraoperative block of the ascending aorta and coronary sinus retrograde continued perfusion was performed,pressure and volume of the coronary sinus perfusion blood from oxygenation machine was controlled,did not use the heart cardioplegia；after major heart operation completion, rewarming was performed, after heart surgery was completed can be stop.Results　Twenty-seven patients all survived,follow-up was performed for 4 to 26 months; sinus rhythm was maintained in 22 patients, atrial fibrillation recurrence in 3, occasional atrial flutter in 2, whose sinus rhythm restored after taking amiodarone. Bleeding was less in operation,and no severe atrioventricular block and cerebral embolism occured.Conclusion　Double valve replacement plus improved maze procedure through continuous coronary sinus retrograde perfusion under middle hypothermia cardiopulmonary bypass has advantages of simple operation, exact effect, shorter duration, high security.]]> 2018/4/27 8:23:45 LUO You-qiao, FANG Hai-ning, TAN Wei,et al. 432true ［Abstract］　Objective　To evaluate the imaging CT findings of atypical solid pseudopapillary tumor of pancreas and pathology correlation,and to analyze the differential diagnosis of it.Methods　Seventy-seven cases of solid pseudopapillary tumor of pancreas all received surgery, and were proved by pathology and immunohistochemistry. Preoperative diagnosis included solid pseudopapillary tumor of pancreas(47 cases), pancreatic cyst(7 cases), pseudocyst(4 cases), pancreatic abscess(5 cases), pancreatic serous cystadenoma(7 cases), pancreatic cancer(5 cases) and pancreatic hematoma(2 cases).The clinical materials of all the 77 cases were retrospectively analyzed and the CT imaging and pathology features of atypical solid pseudopapillary tumor of pancreas were investigated.Results　The patients included 29 males and 48 females with mean age of 41.5 years(range 2～79 years). Eighteen cases complained abdominal masses,12 abdominal distention and 47 asymptomatic. CT imaging examination demonstrated occupying lesions in the and around pancreas, 44 lesions were solid cystic masses, 16 single cystic masses, 10 solid masses and 7 polycystic masses(less than 3). Among all the 77 cases, 29 lesions located at pancreatic head, 25 at pancreatic body, 17 at pancreatic tail and 6 lesions were difficult of locating. With or without complete capsule, the common bile duct and pancreatic duct didn′t expand. Pathologically, the tumor were composed of solid and pseudopapillary structures, and cystic parts were liquefaction, necrosis and dated hemorrhage.Conclusion　It isn′t difficult of diagnosing solid pseudopapillary tumor of pancreas with typically big solid cystic mass, but when solid pseudopapillary tumor of pancreas with single cystic, polycystic or completely solid masses were diagnosed,they should be differentiated from other pancreatic diseases with similar features, especially with pancreatic cancer in older patients. The CT imaging findings and pathology of solid pseudopapillary tumor of pancreas have certain characteristics,which are helpful in the diagnosis.]]> 2018/1/29 9:17:02 YAO Feng-qing 431true ［Abstract］　Objective　To explore the predisposing causes and clinical manifestations of placental abruption(PA), analyze the causes of misdiagnosis and missed diagnosis of PA,in order to improve the accuracy rate of early diagnosis of PA.Methods　The clinical data of 29 cases of PA were retrospectively analyzed.Results　The incidence rate of PA was 0.37%.Of them,the diagnosis of PA were confirmed in 18 cases prenantally(the comfirmed diagnosis group,accounting for 62.07%),PA were misdiagnosed or the diagnosis of PA were missed in 11 cases prenatally(the misdiagnosis and missed diagnosis group,accounting for 37.93%).Mild PA were found in 19 cases,severe PA were found in 10 cases.The main predisposing factors included hypertensive disorders complicating pregnancy,premature rupture of fetal membranes， traumatic factors and supine hypotensive syndrome.The clinical manifestations mainly included lumbar and abdominal distending pain, vaginal bleeding, bloody amniotic fluid,high uterine tension, fetal distress, etc. The incidence rates of lumbar and abdominal distending pain, vaginal bleeding and high uterine tension in the comfirmed diagnosis group were higher than those in the misdiagnosis and missed diagnosis group(P<0.05).The detection rate of PA by B-ultrasound was 58.62%.Cesarean section were performed in 24 cases,vaginal delivery in 5 cases.Conclusion　For lack of characteristic clinical manifestations, PA has a higher rate of misdiagnosis and missed diagnosis,so that it should be necessary to make a comprehensive analysis according to medical history, clinical symptoms and signs, B ultrasonic examination, and electronic fetal cardiac monitoring for timely and reasonable treatment, in order to reduce the incidence of complications of mother and infants.]]> 2018/1/29 9:17:02 ZHOU Xiao-yi,SHI Cai-ying 430true ［Abstract］　Objective　To understand the epidemic situation of encephalitis B(hereinafter referred to as JE) in Qinzhou city, in order to provide scientific basis for effective prevention and control of JE.Methods　The data of epidemic situation of JE in Qinzhou city from 2003 to 2012 were collected and analyzed by descriptive epidemiologic method.Results　From 2003 to 2012 the city′s total of 91 JE cases were reported, the average incidence rate was 0.29 per 100 000;among them 69 cases were children, accounted for 75.82%; men and women accounted for 69.23%, 30.77%;77 cases were 2 ～ 10 years old children, accounted for the total incidence of 84.62%;90 cases occurred from May to July, accounted for 98.90% of the total cases, showed a peak incidence in summer and autumn; Cases were mainly concentrated in rural areas, a total of 65 cases, accounted for 71.43% of the total number of cases.Conclusion　In order to reduce the incidence of JE,it is necessary to mainly strength the JE vaccine routine immunization coverage and timely vaccination work in 2～10 years old children in rural areas, strengthen monitoring and publicity and education works of JE in summer and autumn,and implement the measure of controlling mosquito.]]> 2018/1/29 9:17:02 OU Zhu-ning 429true ［Abstract］　Objective　To perspectively observe the effect of combination of fluticasone propionate(FP) nasal spray and eucalyptol-linonene-pinene enteric soft capsule(ELP) in the prevention of radioactive sinusitis in nasopharyngeal carcinoma(NPC) patients.Methods　Sixty NPC patients were divided into two groups by matched pair design from March 2009 to March 2011 in our department.Patients of the treating group received conventional radiotherapy（RT）, chemotherapy（CT）, FP nasal spray oral ELP.In control group,the patients received CT and RT alone. Six months after treatment the sinusitis was measured by using CT and MRI for the two groups.Results　Following up for six months,the detected rates of sinusitis in the treating group was 40.0% and 76.7% in the control group, there were significantly difference between the two groups (P<0.01).The type and stage sinusitis: type 1,stage1 and type 1,stage2 accounted 41.67% respectively, type 1,stage3, 16.67% in the treating group;and 8.70%,56.52%,34.78% respectively in the control group.There were statistically significant difference between two groups(P<0.05).Conclusion　Combination of FP nasal spray and ELP can reduce the incidence of radioactive sinusitis and it is easy of use.]]> 2018/2/5 8:39:48 HUANG Bo, LAN Gui-ping, WENG Jing-jin, et al. 428true ［Abstract］　Objective　To investigate the incidence, clinical characteristics, risk factors of nonalcoholic fatty liver disease(NAFLD) with primary hepatocellular carcinoma(HCC).Methods　A retrospective analysis was performed.From 1 092 hospitalized patients with HCC, according to “clinical diagnostic criteria for nonalcoholic fatty liver disease in nonalcoholic fatty liver disease diagnosis and treatment guidelines” of fatty liver and alcoholic liver disease study group of Chinese Liver disease Association,72 HCC patients were selected who met the diagnostic criteria of NAFLD.In 72 patients with NAFLD with HCC, incidence, clinical and biochemical indexes, imaging characteristics, survival rate and the risk factors influencing the prognosis were analyzed.Results　In 1 092 HCC patients, there were 72 patients with NAFLD, accounted for 6.6%, average age (60.52±10.21);with type 2 diabetes mellitus in 35 cases，accounted for 48.6%(35/72);body mass index ≥26 kg/m² in 28 cases, accounted for 38.9%(28/72);hypertension 34 cases, accounted for 47.2%(34/72). The main clinical manifestations had no obvious characteristic.In follow-up of 72 patients with NAFLD with primary HCC, 53 cases died; 1, 2, 3 year survival rates were 68.47%, 40.26%, 30.52%. BMI, T2DM, hypertension, ALT, TBIL, DBIL, GGT, CHE on survival rate of NAFLD patients with HCC were statistically significant in univariate analysis, may be the risk factors influencing the prognosis. Multivariate analysis showed that BMI, T2DM were independent prognostic factors. Conclusion　NAFLD is the primary reason for the occurrence of HCC.Obesity, T2DM are independent risk factors influencing the prognosis of patients with NAFLD with HCC.]]> 2018/2/5 8:39:48 TIAN Jing-hui, TANG Yan-xia 427true ［Abstract］　Objective　To observe the clinical efficacy of sanhuang anti-itch lotion for the treatment of eczema.Methods　Eighty-two patients with eczema in the outpatient department of dermatology were divided into two groups:40 patients in treatment group,42 patients in control group.The treatment group was treated by sanhuang anti-itch lotion locally twice a day for two weeks.The control group was treated by anlong daily morning and evening for 2 weeks.Results　After treatment,the curative effect of treatment group was better than that of control group(P<0.01),the total effective rate was higher than that of the control group(P<0.01).After treatment，the treatment group′s eczema score was lower than that in control group(P<0.01),the decline range was greater than the control group(P<0.05).Conclusion　Treatment effect of sanhuang anti-itch lotion in the treatment of eczema is satisfactory.]]> 2018/2/5 8:39:48 FU Xiao-jing, TANG Xian-hua, LIN Xue-ying, et al. 426true ［Abstract］　Objective　To analyze the distribution of pathogenic bacteria and the drug resistance of main pathogen in pus and wound secretion specimens, and to provide the basis of reliable control infection for clinic.Methods　Specimens of 1 111 pus and 3 348 wound secretion were used for bacterial culture in Guangxi people′s hospital from January 2010 to December 2012, and the isolated pathogen were used for identification and drug susceptibility analysis.Results　One thousand four hundred and forty-two pathogenic bacteria were isolated, the distribution of bacteria was as follows: Gram positive cocci accounted for 33.9%(489/1442), Gram-negative bacteria accounted for 58.3%(840/1442), Fungi accounted for 6.2%(322/1442). The top of pathogenic bacteria checked out were as follows: Staphylococcus aureus accounted for 22.3%(322/1442), E. coli accounted for 18.0 %(259/1442), verdigris accounted for 12.8%(185/1442), proteus accounted for 6.0%(87/1442), Acinetobacter accounted for 6.6%(95/1442), coagulase negative staphylococcus accounted for 4.9%(70/1442).Conclusion　The wound purulent infections of the patients in Guangxi people′s hospital are mainly caused by negative bacillus, but Staphylococcus aureus is the primary pathogen of infection, followed by E.coli bacteria, Pseudomonas aeruginosa. Rare bacteria as noka, aiken and actinobacillus are also isolated. Our results show that pathogenic bacteria of wound purulent infection festering present diversification. Pathogens should be timely identified while treatment. And drug should be rationally used according to the results of drug susceptibility.]]> 2018/2/5 8:39:48 ZHAO Li,CHEN Xing-chun 425true ［Abstract］　Objective　To investigate the risk factors of esophageal variceal bleeding(EVB) in patients with liver cirrhosis.Methods　In this retrospective investigation,42 hospitalized patients with liver cirrhosis complicated by EVB in our hospital from February 2001 to September 2011 were selected as EVB group;38 sex-and-age matched hospitalized patients with liver cirrhosis complicated by esophageal varices without bleeding who survived in the corresponding time period were selected as control group.Red-color sign of esophagealgastric fundus varice(RC),degree of esophageal varices,diameter of portalvein (PV_D),thickness of spleen(SP_T）,max depth of ascites（ASmax）,prothrombin time(PT),platelet count(PLT）,serum total bilirubin(TB),serum albumin(ALB),Child-pugh classification, etc, were observed and compared.First all the variables were examined by univariate analysis. Then those with statistical significance in univariate analysis were examined with multivariate analysis using Logistic regression mode,to verify the major risk factors of EVB in patients with liver cirrhosis.Results　There were statistically significant differences in RC,PT,PV_D,SP_T,ASmax and degree of esophageal varices between two groups （P<0.01）.But Logistic regession with multivariate analysis revealed that only RC,PT,PV_D,degree of esophageal varices were correlated with variceal bleeding significantly.Conclusion　RC,PT,PV_D, degree of esophageal varices were major factors which may influence variceal bleeding in patients with liver cirrhostis.]]> 2018/2/5 8:39:26 HU Ming, QIU Ke-wen,FENG Pei-feng,et al. 424true ［Abstract］　Objective　To observe the hemostasis and tissue repair effect of epinephrine combined with lamiophlomis rotata on surface of cervical loop electrosurgical excision procedure(LEEP).Methods　Fifty-seven patients were selected randomly for LEEP therapy who were divided into two groups randomly: observation group（n=30) and control group（n=27）. For subjects in the observation group, epinephrine cervical injection was applied, lamiophlomis rotata was coated on LEEP surface for hemostasis, given oral lamiophlomis rotata capsule for 3 days;while conventional electric coagulation was routinely adopted to stop bleeding for control group.The intraoperative bleeding volume, operating time, diameter and height of resected specimen,pain severity,vaginal bleeding time,vaginal drainage time,post-operation condition were observed.Results　There was no statistically significant difference in the diameter and height of resected specimen between two groups(P>0.05).Compared with the control group, subjects in observation group had less intraoperative bleeding volume, shorter operating time,lighter pain severity,less vaginal bleeding and drainage time. All the differences were statistically significant(P<0. 05 or <0.01).Conclusion　Epinephrine and lamiophlomis rotata have a positive hemostasis effect on surface of cervical LEEP, and is worth being promoted clinically.]]> 2018/2/5 8:39:26 LI Fan,ZHOU Ping 423true ［Abstract］　Objective　To explore the clinical efficacy of methotrexate (MTX) combined with pituitrin in the laparoscopic treatment of tubal pregnancy.Methods　One hundred and forty-eight patients with unbroken tubal pregnancy were treated by laparsocopic fendstration and embryo-taken surgery plus local injection of MTX. The patients were divided into two groups according to whether using pituitrin or not. Observation group(n=74) received injection of MTX combind with pituitrin into the pregnancy tubal; Control group(n=74) received injection of MTX only. The conditions of two groups were observed including bleeding volume, operation time, pregnancy tubal electrocoagulation times, postoperatied blood,HCG level, persistent ectopic pregnancy(PEP) rate, etc.Results　Observation group had less bleeding volume, less operation time, less electrocoagulation times than control group. There were significant differences between two group(P<0.01); While the conditions of postoperative serum HCG level and PEP rate between two groups had no statistical significance(P>0.05).Conclusion　Applying MTX combined with pituitrin in the laparoscopic fenestration opration for ectopic pregnancy has obvious therapeutical effect which can lessen the electrocoagulation injury to tubal tissue and the incidence of PEP effectively.]]> 2018/2/5 8:39:26 QIN Yan-fen,WU Li-ying,QIN Hua-chan 422true ［Abstract］　Objective　To explore the value of the color Doppler ultrasonography in the diagnosis of lower limb artery diseases in patients with type 2 diabetic mellitus.Methods　A retrospective analysis was performed on the ultrasound diagnosis and the ultrasonogram of color Doppler ultrasonography on lower limbs arteries of the 236 cases of type 2 diabetic mellitus which were diagnosed by clinician and compared with the control group(203 cases). The incidence rate of the arteriosclerosis and the distribution of plaque on the lower limb arteries were investigated.Results　The incidence rate of the arteriosclerosis of lower limb of the type 2 diabetes group were significantly higher than that of the control group(P<0.01),and the smooth rate of lumen endometrium of the type 2 diabetes group was lower than that of the control group(P<0.01). The plaques and vessel narrowing and occlusion mainly located in small and medium-sized arteries of distal limb.Conclusion　The color Doppler ultrasonography is an effective method for diagnosing angiopathy of lower limbs arteries of type 2 diabetes patients. The method can accurately and visually determine the pathogenesis and lesion localization and the degree of severity. It has great clinical significance in early diagnosis，prevention and treatment of lower limb artery diseases in type 2 diabetes patients.]]> 2018/2/5 8:39:26 NONG Li-lu，XING Chen-fang 421true ［Abstract］　Objective　To observe the curative effect of Tongxinluojiaonang in treating coronary heart disease and angina pectors.Methods　Two hundred and sixty-eight patients with clinically diagnosed coronary heart disease and angina pectoris were divided into two groups randomly: the treatment group and the control group, with 134 cases in each group.The control group were treated with common pharmaceuticals, while on the basis of abore treatment the treatment group were treated with Tongxinluojiaonang, taking orally 4 capsules each time, three times a day.The course of treatment was four weeks.In the overall process, all cases were monitored by electrocardiogram,dynamic electrocardiogram and blood biochemistry. According to the variation of patient’s condition, some cases were monitored by immediate electrocardiogram,cardiac ultrasonography and treadmill exercise testing.The relating symptoms,heart attacks and glyceryl trinitrate using levels were recorded.Results　The total effective rate of treatment group was 91.79%, and that of the control group 70.15%.The diversity between them was significant（P<0.01）.Conclusion　Tongxinluojiaonang can effectively relieve symptom of stethalgia,sense of suppression in the chest,palpitation and shortness of breath. It can remarkably improve myocardial ischemia, and is an ideal pharmaceutical in treating coronary heart disease and angina pectoris.]]> 2018/2/23 15:16:37 SHI Cheng-jun, CAI Shang-lang, ZHANG Ji-dong 420true ［Abstract］　Objective　To observe the effect of low concentration of ropivacaine combined with sufentanil combined spinal epidural anesthesia(CSEA) for labor analgesia, and discuss its feasibility, effects on mothers and adverse reaction.Methods　Sixty pregnant women were randomly divided into the observation group and the control group with 30 cases in each group. In the observation group, when uterine neck opened about 3 cm, the L_3-4 lumbar puncture was pertormed, and 5 μg sufentanil was injected into subarachnoid, the tube was placed cephalad into epidural cavity until 3.5 cm depth, epidural cavity was connected with a patient-controlled analgesia(PCA) pump. CSEA was performed using a mixture of 0.1% hydrochloric acid ropivacaine with 0.2 μg/ml of sufentanil administered in epidural cavity, in total 100 ml. The control group received routine treatment and did not use any analgesics. At 5, 10, 30, 60 and 90 min after analgesia VAS score, the duration of labor, mode of delivery, neonatal Apgar score, analgesic effect degree of satisfaction and adverse reaction were observed.Results　VAS score between two groups had statistically significant difference. VAS score in observation group was lower than that in control group. Between two groups, the difference in the birth process, and postpartum hemorrhage were not statistically significance. Normal birth rate in the observation group was lower than that in control group(P<0.01), the rate of using oxytocin in the observation group was higher than that in the control group(P<0.05). The difference in mechanical delivery rate and cesarean section rate，neonatal Apgar score had not statistically significance between the two groups. Analgesia effect degree of satisfaction in observation group was better than that in the control group. Two cases with itch of skin were found in observation group，1 case with nausea and 1 cases with lower limb numbness in each group.Conclusion　Low concentration of ropivacaine combined with sufentanil combined spinal epidural analgesia in childbirth had obvious effect and a long time of analygesia and its effect was quick. Although it will increase the rate of using oxytocin, but not affect the rate of cesarean section, with no harmful effects on mother and infant.]]> 2018/2/23 15:16:37 LUO Zhen-ji，MO Yong-hua，LI Tian-jie，et al. 419true ［Abstract］　Objective　To explore the clinical features of neonates with septicemia, as well as the composition of pathogens and antibiotic resistance to guide clinical diagnosis and treatment.Methods　A retrospective analysis was performed of 46 neonates with septicemia who had positive blood culture in 1 560 hospitalized neonates in our hospital from October 2009 to January 2013.Results　The clinical manifestations of neonates with septicemia were lack of specificity. Blood culture results showed staphylococcus was the main pathogenic bacteria, the antibiotics susceptibility test showed that most strains were resistant against penicillin and ampicillin, and partial resistant against the first and second generation of cephalosporins. But it was sensitive to the third generation cephalosporins, sulbactam, aminoglycosides and quinolones, and was highly sensitive to imipenem, vancomycin, teicoplanin.Conclusion　The clinical manifestations of neonates with septicemia were lack of specificity, the main of pathogens is gram-positive bacterium. Monitoring the alteration of drug resistance and choosing the antibiotics according to the results of the drugs susceptibility test, it have important significance for prevention and treatment of neonates with septicemia.]]> 2018/2/23 15:16:37 YANG Wan-qing 418true ［Abstract］　Objective　To analyze and discuss the treatment effect of epidural self-control analgesia in labor.Methods　The clinical data between 46 puerperas treated with compared epidural self-control analgesia(observation group) and 40 puerperas treated with natural labor(control group) was compared.Results　The vital sign,incubation,time of the second stage of labor and Apger between two groups were not different（P all>0.05）,however,the active phase of observation group was shorter than that of control group(P<0.01), the analgesia effect of observation group was better than that of control group(P<0.01). The analgesia total effective rate of observation group was higher than that of control group(P<0.01).Conclusion　The epidural self-control analgesia in labor can improve the labor pain of puerpera,it should be popularized as a labor analgesia treatment.]]> 2018/2/23 15:16:37 WEI Xiu-yan 417true ［Abstract］　Objective　To explore the expression and clinical significance of serum Interleukin-17(IL-17) and Interleukin-23(IL-23) in threatened abortion and missed abortion patients.Methods　The expressions of serum IL-17 and IL-23 were determined using enzyme-linked immunosorbent assay(ELISA) in 25 women with normal pregnancy(NP group), 27 threatened abortion patients(TA group) and missed abortion patients(MA group).Results　There were statistically significant difference in expression of serum IL-17(P<0.01) and no statistically significant difference in expression of serum IL-23(P>0.05) among three groups. Patients in MA group had significantly increased expressions of IL-17 and IL-23 compared with patients in NP group(P=0.001, P=0.044 respectively). There were no statistically significant difference in the expressions of IL-17 and IL-23 between MA group and TA group(P>0.05). There was no significantly statistical difference in the expression of IL-17 and IL-23 between NP group and TA group(P>0.05). There showed no significantly linear correlations in the expressions of IL-17 and IL-23 among the three groups.Conclusion　IL-17 and IL-23 might play a role in the pathogenesis of threatened abortion and missed abortion.]]> 2018/2/23 15:17:06 MAO Jing-xia, LI Min-qing 416true ［Abstract］　Objective　To investigate the role of early nasal continuous positive airway pressure（NCPAP）in the premature infant with respiratory distress syndrome（RDS）.Methods　A total of 91 premature infant with RDS were divided into two groups randomly. In the experimental group(n=49) NCPAP was started when oxygen deficiency occurred；in the control group(n=42) NCPAP was started when the concentration of oxygen inhalation(FiO₂) was >40% and transcutaneous oxygen saturation between 85% and 88%. The rate of mechanical ventilation, the rate of hospital infection and the rate of the chronic lung disease were observed.Results　The rate of mechanical ventilation(32.65%) in the experimental group was lower than that（59.52%）in the control group, so a significant difference existed between them（P<0.05）；the rate of hospital infection( 12.24%) in the experimental group was lower than that（30.95%）in the control group（P<0.05）；the rate of chronic lung disease (8.16%) in the experimental group was lower than that（23.81%）in the control group（P<0.05）.Conclusion　Using early NCPAP in the premature infant with respiratory distress syndrome can reduce the rate of mechanical ventilation, the rate of hospital infection and the rate of chronic lung disense obviously.]]> 2018/2/23 15:17:06 WANG Ai-wu 415true ［Abstract］　Objective　To analyze the concentration and significance of homocysteine and non-high density lipoprotein cholesterol in diabetes patients with cerebral infarction.Methods　One hundred and thirty-two patients with cerebral infarction were divided into two groups: 49 patients in T2DM group, 83 patients in non-diabetic group, with 58 healthy people as normal control group.Determination of Hcy,TC,TG,HDL-C,LDL-C were performed, the non-HDL-C was calculated.Results　There were statistically significant different in above six indexes among three groups（P<0.01）.The level of serum Hcy， TG in T2DM group and non-diabetic group were significantly increased, the level of HDL-C significantly reduced（P<0.01）; the level of non-HDL-C in T2DM group were significantly higher than that in healthy control group（P <0.01）.The level of serum TC,LDL-C and non-HDL-C in T2DM group were significantly higher than those in non-diabetic group（P<0.05）. No relationship was found between Hcy and blood lipid in patients with cerebral infarction; non-HDL-C was positively correlated with TC,TG and LDL-C.Conclusion　The level of serum Hcy,non-HDL-C in T2DM patients with cerebral infarction were significantly increased, which can be used as cerebral infarction risk prediction and effectiveness evaluation index of glucose-lowering and lipid-lowering treatment.]]> 2018/3/12 9:42:55 LV Jun,LV Mei,CHEN Si-jia 414true ［Abstract］　Objective　To evaluate the efficacy of reduning injection in the adjuvant treatment of community acquired pneumonia in children.Methods　Two hundred children with community acquired pneumonia were divided randomly into the therapy group and the control group (100 patients for each). Both groups were treated with the same routine treatment, and the therapy group was given reduning injection via vein as an adjuvant therapy for 5～10 days besides routine treatment.Results　The total effective rate and the obvious effective rate of in therapy group were 96.00% and 76.00% respectively,and that of the control group were 88.00% and 57.0% respectively, there was a statistic significance between two groups (P<0.05 or P<0.01).The scores and disappearing time of fever,cough,shortness breath and pulmonary rattle and the days in hospital of therapy group were much better than that of control group (P<0.05 or P<0.01).Conclusion　Reduning injection used as adjuvant therapy for community acquired pneumonia can enhance the effectiveness and shorten the duration with little side effect.It is worthy of application.]]> 2018/3/12 9:42:55 DENG Wen-xue 413true ［Abstract］　Objective　To explore the clinical efficacy of rectal administration of misoprostol in prevention of postpartum hemorrhage after cesarean section.Methods　From January 2011 to December 2011, Two hundred-twenty parturient women with postpartum hemorrhage risk factors for cesarean section were randomly divided into experimental group and control group with 110 cases in each group. In both groups oxytocin 20 U was injected into the uterine body of parturient women after the baby was delivered during cesarean section, at the same time intravenous infusion of oxytocin 20 U was performed. In the experimental group at the end of surgery and after removing vaginal hemorrhage, misoprostol 400 μg was placed at depth of 4～5 cm within the rectum. At 2 h and 24 h after operation,vaginal bleeding were observed and the blood pressure, heart rate, and adverse drug reactions after drug administration were observed.Results　At 2 h and 24 h after operation blood loss in the experimental group was significantly less than that in the control group(P<0.01). Before and after treatment,between the two groups there was no statistically significant difference in maternal blood pressure, heart rate, breathing, and the incidence of adverse drug reactions(P>0.05).Conclusion　Rectal administration of misoprostol in the prevention of postpartum hemorrhage after cesarean section has better efficacy and is worthy of promotion.]]> 2018/3/12 9:42:55 LIU Wei-wu 412true ［Abstract］　Objective　To compare the efficacy between pioglitazone and metformin in the treatment of patients with type 2 diabetes.Methods　Ninety-six petients with type 2 diabetes were divided into a control group and a treatment group based on treatment order, each group had 48 patients. The control group were treated with metformin; the treatment group were treated with pioglitazone. One month after treatment, the control conditions of blood glucose were compared between two groups.Results　After one month of the medication, the total effective rate of control group was 87.5%(42/48), that of the treatment group was 89.6%(43/48), there was no statistically significant difference between two groups(P>0.05). In treatment group, the fasting plasma glucose and 2 h postprandial blood sugar level improved slightly larger than the control group（P>0.05）; the incidence of adverse reactions of the control group was more than that of treatment group(P<0.01).Conclusion　Metformin, pioglitazone can effectively control blood glucose of patients with type 2 diabetes.]]> 2018/3/12 9:43:40 ZHANG De-cheng 411true ［Abstract］　Objective　To study the value of corneal topography guided LASEK operation in the treatment of patients with high myopia.Methods　Sixty patients with high myopia treated in our hospital from 2011 January to 2012 July were used as the object of investigation. These patients were randomly separated into two groups: control group and observation group. The patients in the observation group were corrected vision by using corneal topography guided LASEK operation, and the control group received ordinary LASEK operation, and the differences in postoperative uncorrected visual acuity, residual diopter and adverse event reporting rate were compared between two groups.Results　There was no statistically signicant differences in vision acuity after operation between two groups (P>0.05). But there was a statistically difference in residual diopter and adverse event reporting rate between two groups(P<0.05 or P<0.01).Conclusion　Corneal topography guided LASEK operation in the treatment of patients with high myopia shows good efficacy and safety, and it has an important value in clinical applitation.]]> 2018/3/12 9:43:40 HE Bi-hua,XIE Xiang-yong,WEI Li-jiao 410true ［Abstract］　Objective　To systematically and quantitatively evaluate the diagnosis accuracy and diagnostic characteristics of ultrasound and molybdenum target imaging technique for breast disease and provides valuable guidance for selection of image examination for breast diseases.Methods　The ultrasonographic characteristics of color Doppler ultrasound and molybdenum target imaging of 237 mammary nodules in 228 cases were analyzed and histopathological findings was used as a gold standard to compare and analyze the diagnostic value of Doppler ultrasound, X-ray mammography or their union for benign and malignant breast lesions.Results　Benign lesion was found in 188 cases (194 nodules), malignant in 40 cases (43 nodules).Color Doppler ultrasound in diagnosis of malignant lesions had a sensitivity of 46.5%, specificity of 80.4%, accuracy of 74.2%, X-ray mammography in diagnosis of breast malignant lesion had a sensitivity of 55.8%, specificity of 75.2%, accuracy of 71.7%, the combination of two methods in diagnosis of breast malignant lesion had a sensitivity of 90.6%, specificity of 89.6%, accuracy of 89.8%.Conclusion　Doppler ultrasonography and X-ray mammography in the diagnosis of breast cancer have a higher value; the combination of the two methods can improve the accuracy of differential diagnosis for breast benign and malignant tumors and has important clinical value in the diagnosis and establishing of treatment plan.]]> 2018/3/12 9:43:40 MO Xian-ling, PENG Chang-li 409true ［Abstract］　Objective　To investigate the correlation between the grading of perirenal space involvement and the clinical severity (Ranson criteria) in acute pancreatitis (AP).Methods　CT scanings and clinical data of 75 consecutive patients with AP were reviewed retrospectively. The involvement of perirenal space and clinical severity of AP were graded using perirenal space involvement criteria and Ranson criteria respectively. The grade of perirenal space involvement in AP was correlated with the grade of clinical severity criteria (Ranson criteria) with ranking test.Results　The Spearman correlation coefficient of morphologic grade of perirenal space involvement with CT in AP correlated with clinical severity classified by Ranson criteria was 0.575(P < 0.01).Conclusion　Perirenal space involvement in AP was positivley correlated with clinical severity (Ranson criteria), so the perirenal space involvement could be chosen as an adjunctive criteria to evaluate thoroughly the range, degree and severity of the disease.]]> 2018/3/12 9:43:40 PENG Xiao-rong, HUANG Yu-xin, CHEN En-yan 408true ［Abstract］　Objective　To investigate the treatment effect of acute left ventricular failure by non-injury positive pressure ventilation.Methods　Thirty-one patients with acute left ventricular failure were randomly divided into treatment group(n=15) and control group(n=16). The parameter of heart rate, respiration, blood pressure, blood oxygen saturation and the heart function change were investigated between the treatment group (using NIPPV besides conventional treatment) and the control group (using conventional methods, include of oxygen inhalation, streng myocardial contraction, diuresis, vasodilator and so on) at 1 hours and 6 hours after treatment, respectively.Results　At 1 hour and 6 hour after treatment,there were statistically significant difference between two groups in the parameter of heart rate, respiration, blood oxygen saturation (P<0.05). The difference of blood pressure was no statistically significant between two groups (P>0.05).Conclusion　Non-injury positive pressure ventilation combined with routine therapy can significantly improve symptoms of patients with acute left ventricular failure, and save the life of patients.]]> 2018/3/12 9:43:40 WANG Bao-yu, WU Hai-yan 407true ［Abstract］　Objective　To explore the value of the clinical practice of MSCT-guided percuteneous pucture biopsy in intrapulmonary non characteristic occupying lesions.Methods　The operating methods and processes of MSCT-guided percuteneous puncture biopsy were analyzed in 68 patients with intrapulmonary non characteristic occupying lesions.The results of examination and the complications were analyzed.Results　 MSCT-guided percuteneous puncture biopsy were performed smoothly and successfully.There was no complications among the 68 patients,only 10 of them had a little pneumothorax,and restored to health after a simple treatment.In about 55.9% of 68 cases of intrapulmonary non characteristic occupying lesions,the pathological findings showed the pathological changes of non-malignant lesions.Conclusion　In more patients with intrapulmonary non characteristic occupying lesions.The pathological changes are non-malignance.It’s particularly important for them to make diagnoses and treatment,but the advantages of MSCT-guided percuteneous puncture biopsy include easy operation,more reliable result, and less complications and it has a higher clinical value.]]> 2018/3/12 9:43:40 LIU Zheng 406true ［Abstract］　Objective　To understand the HIV infection status of the unpaid blood donors in Liuzhou.Methods　The HIV infectious markers were detected in total of 187 069 samples of the unpaid blood donors, which were collected from 2008 to the first half of 2011. The HIV infection rate was collected. The HIV infector was informed and follow-up for the first time was performed. The relation epidemiological investigation was carried out.Results　2008～2011 HIV infected rate(1/100000) in unpaid blood donors was 52.43,75.13,57.01and 52.27 in Lizhou.The total infected rate was 60.41/100000,man ratio woman was 1.51∶1.79.65% of the positive was 20～39 years old,76.99% of the positive knew little about HIV,and 50.44% were infected by sexual transmition.Conclusion　The increasing trend of HIV infection rate of Liuzhou were contained, but the situation was still severe. The main infectors were young adult, with a growing trend towards the low age and older crowd. Sexual behavior was the main infection way. And the epidemic pattern was diversity.]]> 2018/3/21 8:06:39 ZHOU Zhong-min,WANG Li,LIU Qiao-mei 405true ［Abstract］　Objective　To explore the principle and methods of perioperative management of esophageal carcinoma patients with type 2 diabetes mellitus.Methods　In diabete group 35 esophageal carcinoma patients with type 2 diabetes mellitus were selected and insulin was regularly and strictly used to control patients’ blood glucose during perioperative period.The control group consisted of 35 esophageal cancer patients without diabetes mellitus receiving operation.Results　In diabete group,there were 30 patients who underwent radical resection and 5 patients in advanced stage who underwent gastrotomy ;all the patients passed the perioperative period smoothly.After surgery,there were 3 patients with arrhythmia, 1 patient with chylothorax,2 patients with incision infection,5 patients with anastomotic leakage,4 patients with pulmonary infection；In control group,there were 28 patients who underwent radical resection and 7 patients in advanced stage who underwent gastrotomy.After surgery,there were 2 patients with arrhythmia, 1 patient with chylothorax,1 patients with incision infection,2 patients with anastomotic leakage,2 patients with pulmonary infection.In the comparison of postoperative recovery and complication rate, there was no significant difference between two groups (P>0.05).Conclusion　In the perioperative treatment effect,the diabete group is similar to control group,if perioperative treatment is strengthened and blood glucose is strictly controled.]]> 2018/3/21 8:06:39 WU Da-shu 404true ［Abstract］　Objective　To investigated the effect of micro-implant in the treatment of Angle Class Ⅱ division 1 classification and provide a theoretical basis for clinical promotion of the use of micro- implant.Methods　Sixty-four patients with Angle Class Ⅱ Division 1 Malocclusion, 32women and 32 men，with average age of (22.78±3.26)years old, were randomly divided into control and experimental groups.In the control group,the patients treated with J hook,in the experimental group，the patients treated with micro-implant,before and after treatment, the change of cephalometric and model indexs were measured and analyzed.Results　Two groups could take the correction of Angle Class Ⅱ division 1 malocclusion, but in the experimental group ANB Ls-E, U1-L1, U1-MP, U1-NA, U6-PP, the SNA indicators more well than those in the control group (P<0.05 or <0.01). The control group treatment course was (18±2)months, the experimental groups treatment course of (12±2)months, in the experimental group was significantly reduced treatment time(P<0.05). In the index of OJ and OB，the experimental group was better than the control group(P<0.01).Conclusion　Micro-implant treatment could corrected Angle Class Ⅱ Division 1 Malocclusion well.]]> 2018/3/21 8:06:39 LI Da-jian, CHEN Hua, GONG Li-ling 403true ［Abstract］　Objective　To observe the effect of montmorillonite powder combined with mannitol in the treatment of patients with pesticide poisoning by mouth.Methods　Acording to the visiting order and number of toxicant species,132 patients were randomly divided into A group and B group with 62 patients in each group. All patients were treated according to routine. On the routine treatment B group was treated with oral administration of montmorillonite powder 9 g dissolved in 250ml saline and oral administration of 20% 250～500 ml mannitol at 2 h of intervals,twice a day,for 2 days.Between the two groups,the number of patients with rebound phenomenon,the number of patients with cases of intermediate syndrome and the number of days of hospitalization were compared.Results　The clinical effects in B group was better than that in A group,no rebound phenomenon was foud in B group.Conclusion　The clinical effect of montmorillonite and mannitol in the treatment of organic phosphorus pesticide poisoning is better.]]> 2018/3/21 8:06:39 WANG Jun 402true ［Abstract］　Objective　To investigate the clinical curative effect of integrated traditional Chinese and western medicine in the treatment of children with chronic sinusitis.Methods　One hundred and thirty-five children with chronic sinusitis were randomly divided into observation group(n=68) and control group(n=67). The observation group was treated by oral cocklebur rhinitis dropping pills,loratadine particle,and local spraying of activated silver ion antibacterial liquid; The control group was treated by oral cefetamet pivoxil tablet,loratadine particle,and local spraying of activated silver ion antibacterial liquid. The course was 14 d.Results　The total effective rate of observation group was 82.35%,that of control group was 64.18%,there was statisfically significant olifference in the total effective rafe between two groups (P<0.05).Conclusion　Application of cocklebur rhinitis dropping pills,loratadine particle,and local spraying of activated silver ion antibacterial liquid in the treatment of children with chronic sinusitis has good curative effect,and avoids the side effects of the antibiotics.]]> 2018/3/21 8:06:39 LI Ying-rui 401true ［Abstract］　Objective　To explore the best time and mode of termination of pregnancy for early-onset severe preeclampsia.Methods　The clinical data of 86 cases of early-onset severe preeclampsia treated from January 2005 to December 2011 were retrospectively analysed. The complications and pregnancy outcome in different weeks of pregnancy were compared.Results　The survival rate of newborn whose week of pregnancy less than 30 weeks was low,but complications rate of the mater was low；the survival rate of newborn whose weeks of pregnancy between 30 and 34 was higher than other pregnant weeks, prevalence rate was lower with the increase of the gestational weeks of newborn. The complications rate of mater did not increase obviously with weeks of pregnancy extended less than 14 days.Conclusion　The best time of termination of pregnancy for early-onset severe preeclampsia is about 34 weeks. The fetus whose survival possibility is small, should choose vaginal delivery mainly.]]> 2018/3/21 8:06:39 MO Xiao-chen 400true ［Abstract］　Objective　To explore the clinical effect of long stem cemented bipolar femoral head prosthetic replacement in the treatment of elderly patients with unstable femoral intertrochanteric fracture.Methods　Sixty-two patients aged above 75 years old who suffered from unstable femoral intertrochanteric fractures were treated by long stem cemented bipolar femoral head prosthetic replacement from January 2005 to July 2010. The average follow-up time was 15 months, the postoperative complications, the fracture healing time and joint function were observed.Results　There was no death case in 53 patients who were followed up. Deep venous embolism of lower limbs was found in one patient, who was cured and discharged after treatment. No complicationts, such as bad sore, pulmonary infection, hip dislocation and so on were found. According to the standard of harris, excellent effect was found in 43 patients (81.1%), good in 7 pationts (13.2%), fair in 3 patients (5.6%). The excellent and good rate was 94.3%.Conclusion　The long stem cemented bipolar femoral head prosttcetic replacement in the treatment of elderly patient with unstable femoral intertrochanteric fracture has advantages of less trauma, shorter operative time, earlier ambulation, less complications, better recorery of hip function and so on. and it is an more ideal treatment method.]]> 2018/3/21 8:07:41 SU Yun-yu,LIN Shu-ti,ZHOU Dong 399true ［Abstract］　Objective　To analyze the relationgship between pathology and CT,MRI of craniofacial fibrous dysplasia of bone,to evaluate the diagnostic value of CT and MRI.Methods　Twenty-two CT images and 6 MRI images were retrospectively analyzed in 28 cases of craniofacial fibrous dysplasia of bone proved by pathology.Results　Of 28 cases,12 cases were of monostotic type,and 16 cases were of polystotic type. CT findings of 22 cases were divided into four types,ground-glass type in 8 cases,worm-eaten type in 6 cases,sponge ground-flesh type in 5 cases，sclerotic type in 3 cases；and inhomogeneous enhancement was revealed in 3 cases.Canal of optic nerve,supraorbital fissure,carotid groove,foramen lacerum,nasolacrimal duct,nasal meatus,foramen rotundum,foramen ovale were involved in 5,4,2,2,2,2,1,1 cases.Four of all 6 MRI examinations displayed low signal intensity on both T1WI and T2WI,and two of all the 6 mainly displayed equal or low signal intensity,inhomogeneous enhancement was revealed in 2 cases.Conclusion　The imaging finding of craniofacial fibrous dysplasia of bone is diversification,CT and MRI have important value to diagnose the disease,they can reflect the pathological types of the disease.]]> 2018/3/21 8:07:41 LV Yong-ge,LUO Di-lin,ZHUAN Qing-chun,et al. 398true ［Abstract］　Objective　To study the cause of decrease of fetal monitoring fetal heart rate baseline thin variability(DFMV)and the relationship between DFMV and fetal intrauterine stockpiling ability.Methods　The clinical data of 74 cases of late pregnancy was chosen from obstetric clinic of them, forty-two pregnant women received cesarean section due to fetal distress with the nonreactive type of non-stress test(study group).Thirty-two received cesarean section due to other obstetric indcafions with reactive type of non-stress test in the same period (control group).The clinical data was analyzed for the two groups,including the causes of DFMV,the effect of DFMV on the fetal intrauterine stockpiling ability and the fetal prognosis.Results　In the study group,the umbilical cord abnormal ratio was 64.29%.There was statistcally significant(P<0.05) compared with the control group.Conclusion　For the pregnant women with DFMV and abnormal umbilical cord, terminating pregnancy in time during late pregnancy period would lower the newborn distress rate and the asphyxial degree.]]> 2018/3/21 8:07:41 HUANG Lin,WU Yue-lian 397true ［Abstract］　Objective　To improve the recognition of the emergency treatment of the non-typical diabetic ketoacidosis and reduce the occurrence of misdiagnosis and missed diagnosis.Methods　The data of 22 emergency cases of diabetic ketoacidosis which were treated in our emergency room in the past four years was collected and the clinical data of misdiagnosis and missed diagnosis in 4 cases was retrospectively analyzed.Results　Among 22 cases, 4 cases were misdiagnosis or missed diagnosis,the rate of misdiagnosis and missed diagnosis was 18.2%.In these 4 cases there did not have the history of diabetes, the onset time was very short and there was no any symptoms or signs of diabetic ketoacidosis when they came in for the emergency care.Conclusion　To strengthen the case history talking and do a thorough examination on the emergency patients, strengthen the tesing of blood sugar,blood biochemical and urinalysis,which can reduce the occurrence of misdiagnosis or missed diagnosis.]]> 2018/3/21 8:07:41 JIANG Chun-fa, HE Sheng, QIU Quan-huang,et al. 396true ［Abstract］　Objective　To investigates the distribution and drug resistance of pathogens in children with pneumonia in Binyang county.Methods　Bacteral identification and susceptibility test were done for 1 325 sputum specimens of children with pneumonia in Department of paediatrics,Binyang Women and Children Health Hospital from Jan. 2011 to Dec. 2011.Results　In 1 325 cases,16 pathogenic bacteria and 403 strains were separated from the sputum samples,the total positive rate was 27.5%. The chief pathogens were Gram positive bacilli accounting for 52%. Gram negative bacilli accounting for 48%.Gram negative bacilli were highly resistant to penicillins and cephalosporins.All of Klebsiella pneumoniae and Escherichia coli sensitive to Meropenem. Gram positive bacilli was completely resistant to Penicillins, Clindamycim, Erythromycin and SXT, but was sensitive to Vancomycin, Rifampin,Levofloxacin.Conclusion　The most common pathogens in the children with pneumonia in Binyang county were Streptococcus pneumoniae and Eschrichia coli;the next were Staphylococus aureus and Klebsiella Pneuonia.These pathogens have varying degree of resitance to antibiotics. The rational use of antibotics can reduce generation of drug-resistant pathogens or slow down its development.]]> 2018/3/21 8:07:41 WEI Qiu-ling 395true ［Abstract］　Objective　To investigate effect and safety of dydrogesterone and Baotai wuyou tablets in the treatment of early threatened abortion clinical curative.Methods　According to random number table, 132 cases of early threatened abortion patients were divided into group A and group B （each group=66）in our hospital. All patients were given routine tocolytic therapy, in addition, group A were given oral dydrogestrone, group B was given Baotai wuyou tablets. Two groups of patients were observed before and after treatment about human chorionic gonadotropin ( HCG ), time of remission and disappearance time, adverse drug reactions, Baotai success rate, incidence of pregnancy and delivery complications and adverse neonatal outcome.Results　HCG, time of remission and disappearance time had no significant difference between two groups (P>0.05); Baotai success rate of group A was 90.9%, group B 92.4%, there was no significant differences between the two groups (P>0.05); The incidence of adverse drug reactions in group B was obviously lower than group A (P<0.05); There were no statistical significant difference in incidence of pregnancy and delivery complications and adverse neonatal outcome between the two groups of pregnancy(P>0.05).Conclusion　The efficacy of dydrogesterone and Baotai wuyou tablets in the early treatment of threatened abortion is satisfactory. Adverse drug reaction rate of Baotai wuyou tablets is relatively low, and is more suitable for using widely in basic hospital.]]> 2018/3/21 8:07:41 ZHU Li-xin 394true ［Abstract］　Objective　To probe into the clinical effect of hysteroscope combined with progynova in curing refractory intrauterine pregnancy residues.Methods　Thirth-five patients with the refractory intrauterine pregnancy residues in the treatment group were treated by hysteroscope combined with progynova；another 30 patients in the control group were treated by traditional invisible therapy.These two groups were compared from the aspect of their postoperative cure rate, intraoperative blood loss, postoperative vaginal bleeding duration, menstruation recovery and postoperative cervical intrauterine adhesions.Results　The disparity in the comparison between two groups is significant statistically (P<0.05 or P<0.01).The effect of the treatment group was better that of the control group.Conclusion　The therapy of hysteroscopy combined with progynova has notable effect in the cure of refractory intrauterine pregnancy residues, and it is a simple and safe operation, and worthy of the spread in clinical application.]]> 2018/3/21 8:07:41 WU Qin-fen 393true ［Abstract］　Objective　To investigate the efficiency and safety of NovaSure system for menorrhagia.Methods　Sixty-six women with menorrhagia received NovaSure system for treatment. The clinical effect and complications were followed up at months 1, 3, 6 and 12.Results　The procedures was completed successfully in all the patients. The rate of efficiency was 98.48%, 98.08%, 97.06%, 100.00% respectively at months 1, 3, 6 and 12. And the rate of amenorrhea was 43.94%, 53.85%, 55.88%, 62.50% respectively. There was no significant difference in the rate of efficiency and amenorrhea among 1, 3, 6 and 12 months(P>0.05). No intraoperative or postoperative complications occurred.Conclusion　NovaSure shows high and stable efficiency and safety. It is worthy of clinical application.]]> 2018/1/24 8:18:05 WEI Li-ying，ZHAO Ren-feng， LI Xue， et al. 392true ［Abstract］　Objective　To investigate the clinical effect of vitrectomy for Terson syndrome.Methods　The clinical data of 18 patients （19 eyes）with Terson syndrome undergoing vitrectomy was analyzed retrospectively.Results　The vitreous cavities of 19 eyes were all clear after operation, retina were flat,and there was not complications related to operation, the visual acuity of 18 eyes(94.7%) improved and that of one eye(5.3%) decreased after operation; the improving rate of visual acuity was 100.0%(19 eyes) and retinal detachment was found in one patient(5.3%) 2 months after operation.Conclusion　Vitrectomy was an effective method for Terson syndrome and with low complications.]]> 2018/1/24 8:18:05 HAO Xiao-yan, WANG Xian, PAN Han-ying 391true ［Abstract］　Objective　To discuss the re-pregnancy after the treatment of tubal pregnancy with two conservative methods.Methods　A retrospective analysis was conducted on clinical data of 125 nulliparous patients of tubal pregnancy treated with conservative methods in our hospital from March 2005 to March 2008. According to different methods, they were divided into two groups, group A, including 65 patients with salpingotomy and embryo collection under laparoscope plus local MTX injection, and group B, including 60 patients with drug conservative treatment. Two groups were compared in postoperative uterine pregnancy, ectopic pregnancy again and secondary infertility.Results　The incidence of uterine pregnancy in group A was higher than that in group B(P<0.05) and the incidence of secondry infertility in group A was lower than that in group B(P<0.05),but there was no statistically significant difference in incidence of ectopic pregnancy again between two groups(P>0.05).Conclusion　The treatment of nulliparous patients of tubal pregnancy with salpingotomy and embryo collection under laparoscope plus local MTX injection is better than drug conservative treatment.]]> 2018/1/24 8:18:05 LI Jian-xiang,LU Su-juan,LIANG Chan-yu,et al. 390true ［Abstract］　Objective　To evaluate the efficacy and toxicity of paclitaxel liposome combined with cisplatin as induction chemotherapy in the treatment of cervical cancer.Methods　Seventy-three patients who received chemotherapy of paclitaxel liposome combined with cisplatin(TP program) and 5-fluorouracil(FP regimens) were retrospectively analyzed.There were 41 patients in TP group and 32 patients in FP group.All patients received induction chemotherapy combined with the afterloading radiotherapy 15～20 Gy for two courses of treatment.Results　The efficiency of TP group and FP group were 75.6% and 46.9% respectively, the efficient of TP group was higer than FP group(P<0.05),there was no statistically significant difference in the toxic side effects between two groups（P all >0.05）.Conclusion　Chemotherapy of paclitaxel liposome combined with cisplatin is a very effective induction chemotherapy which can control the progression of tumor and treat the tumor before surgery .]]> 2018/1/24 8:18:05 GUO Yi, ZHU Jin-xian 389true ［Abstract］　Objective　To investigate the preventive effects of continuous T-tube low negative pressure suction on pelvic lymphatic cyst formation after radical operation on cervical carcinoma.Methods　From January to December 2012, 90 patients after radical hysterectomy and pelvic lymphadenectomy for cervical carcinoma were divided into group A(no drainage in the pelvic cavity, 45 cases) and group B(T-tube suction and low negative pressure drainage in the pelvic cavity, 45 cases). The occurrence rate of lymphatic cyst after operation between the two groups were observed.Results　The occurrence rate of lymphatic cyst in group A was 26.7%（12/45） and that in group B was 2.2%（1/45）. There was statistically significant difference in occurrence rate lymphatic cyst between two groups （P<0.01）；There was no significant difference in occurrence site of lymphatic cyst between the two groups after operation（P>0.05）.Conclusion　The T-tube negative pressure suction can reduce the occurrence rate of lymphatic cyst in the patients after radical operation of cervical carcinoma.]]> 2018/1/24 8:18:05 YU Ying 388true ［Abstract］　Objective　To explore the main influence factors of the target organ damage in the diabetes patients.Methods　Fifty-six diabetes patients with target organ damage(ODM group) and 40 diabetes patients without with target organ damage(DM group) were detected.The urine micro protein was tested with automatic chemical immune luminescence method and the albumin excretion rate(UAER) was calculated. D-D was detected with fully automatic blood coagulation analyzer and serum hs-CRP levels with scattering turbidimetric method. Color doppler ultrasound was used for detecting common carotid artery intima-media thickness(IMT) and left ventricular mass index(LVMI). The detected abnormal results were used as indexes of target organ damage in the diabetes patients and the two groups were compared of gender, age, course, glycosylated hemoglobin(HbA1c), total cholesterol(TC), triglycerides(TG), low density lipoprotein cholesterol(LDL-C), hypertension.Results　Course,age, HbA1c,TC,TG, LDL-C, hypertension, UAER, hs -CRP, D-D were increased in ODM group, compared with DM group ,the difference between two group were statistically significant(P<0.01). The multi-factor Logistic stepwise regression analysis showed that LDL-C、hs-CRP had significant effect on the target organ damage in diabetes patients(P<0.05).Conclusion　LDL-C,hs-CRP are closely related to the occurrence and development of target organ damage in diabetes patients, and can be used as reference indexes for evaluating prognosis and therapeutic effect of diabetes.]]> 2018/1/24 8:18:34 LI Ni, ZHONG Mei, LIAO Ke-hua, et al. 387true ［Abstract］　Objective　To explore the character of molecular genetics,clinicopathologic features,diagnosis and differential diagnosis of retroperitoneal dedifferentiated liposarcoma with heterogeneous rhabdomyosarcoma and neuroendocrine differentiation.Methods　A retrospective analysis was performed on clinicopathologic process, immunohistochemistry, histopathology diagnosis and differential diagnosis in a case of dedifferentiated liposarcoma with heterogeneous rhabdomyosarcoma and neuroendocrine differentiation and related literature were reviewed.Results　There were two elements in the tumor. The differentiated elements included well-differentiated Lipoma-like liposarcoma and inflammation-xanthogranuloma; dedifferentiated element included high-grade malignant pleomorphism undifferentiated sarcoma and low-grade malignant aggressive fibromatosis and myxofibrosarcoma. The dedifferentiation components included heterogeneous rhabdomyosarcoma and neuroendocrine differentiation.Immunohistochemistry assay showed positive included: Viment,CD68,CDK4,FLi-1,MyOD1,Myogenin,NSE,CD56,Bcl-2,Desim,negative included CD34, LCA,MDM2,CK-AE1/AE3.Suspectde positive included CgA,Syn,S-100,CD99.Ki-67(+)>60%.Conclusion　The retroperitoneal enormous tumor has two distinct differentiations and morphologic components with heterogeneous components differentiations.The complexity and polymorphism often make diacrisis difficult.It is important to master histopathology and immunohistochemistry in diagnosis and differential diagnosis of this tumor.]]> 2018/1/24 8:18:34 XIE Kai-sheng,ZHANG Bin,ZHENG Shao-guang,et al. 386true ［Abstract］　Objective　To investigate the therapeutic effects of valsartan,carvedilol and dopamine in the treatment of epidemic hemorrhagic fever(EHF) patients with acute renal failure(ARF).Methods　One hundred and sixteen EHF patients with ARF were randomly divided into the control group and the treatment group with 58 cases in each group.The control group received conventional therapy， including antiviral treatment, hemostatic treatment,maintaining internal environment balance, early use of diuretics, purgative therapy;the treatment group, on the basis of conventional therapy, was treated with valsartan,carvedilol and dopamine. The curative effects of two groups were observed.Results　Compared with the control group,in the treatment group, urinary protein disappeared more quickly, the polyuric period appeared more early, the time of urea nitrogen returning to normal was shorter, the incidence of complications more lower,the number of dialysis patients reduced, the outcomes of dialysis patients were better,the cure rate was higher.Conclusion　Valsartan, carvedilol and dopamine have significant efficacy in the treatment of EHF patients with ARF.]]> 2018/1/24 8:18:34 DAI Guo-ze 385true ［Abstract］　Objective　To compare the effects of polylactic acid anti-adhesion gel and sodium hyaluronate in the prevention of postoperative intestinal adhesion, to guide the clinical use of drugs.Methods　According to the selected anti adhesion drug, the patients were divided into polylactic acid anti-adhesion gel group and sodium hyaluronate group, and were coated with polylactic acid anti-adhesion gel or sodium hyaluronate on the surgical wound at the end of operation and before closing abdomen. After operation, the time of temperature returning to normal, intestine ventilation time and the intestinal adhesion performance at 6 months after operation were observed.Results　In all patients, postoperative improvement was in good condition and no drug allergies, abscess, fistula and other adverse reactions were found. Observation of postoperative 1 week showed patients′ heating time, borborygmus recovery time, anal exhaust time, in polylactic acid anti-adhesion gel group were significantly better than those of sodium hyaluronate group(P<0.01). At 3 months or at 6 months after operation, the number of patients with intestinal adhesion performance in polylactic acid anti-adhesion gel group was significantly less than that in the sodium hyaluronate group(P<0.05).Conclusion　Polylactic acid anti-adhesion gel and sodium hyaluronate in preventing postoperative intestinal adhesions have obvious effects, but the prevention effect of polylactic acid anti-adhesion gel is better than that of sodium hyaluronate.]]> 2018/1/24 8:18:34 LI Kun, LIU Ying-zi,GAO Hui-cong 384true ［Abstract］　Objective　To probe whether serum albumin and prealbumin can be used as a prognostic indicator of death by observing the relationship between serum albumin, prealbumin and death in hospitalized patients with acute respiratory distress syndrome(ARDS).Methods　The clinical data of 50 cases of hospitalized patients with ARDS were retrospectively analyzed, the influence on mortality of different serum albumin and prealbumin levels was studyed, multi-factor Logistic regression analysis was carried on to pick out prognostic risk factors for death.Results　Twenty-eight patients died and 22 survived, the serum albumin and prealbumin levels of the die group was lower than that of the survival group(P<0.05), the lung injury scores was higher than that of the survival group(P<0.05). The fatality rate of the low prealbumin group was higher than that of the normal or elevated prealbumin group; the fatality rate of lower albumin group was higher than that of the normal albumin group(P<0.05). COPD history, diabetes history, albumin, prealbumin level and lung injury score were risk factors for prognosis of ARDS death, the OR values of albumin and prealbumin were 2.543 and 3.008 respectively.Conclusion　Albumin and prealbumin could be used to predict the death prognosis of ARDS patients.]]> 2018/1/29 9:14:33 ZHANG Yi 383true ［Abstract］　Objective　To compare the therapeutic effects between mosapride and domperidone in the treatment of postprandial discomfort syndrome(PDS).Methods　Fifty-eight cases of PDS according to RomeⅢ PDS diagnostic criteria were randomly assigned into two groups according to admission order. In the A group,30 cases patients were treated with mosapride tablets:5 mg 3 times daily, taken before meals, in the B group, 28 patients were treated with domperidone tablets: 10 mg, 3 times daily, taken before meals, the course were 28 days. After the end of treatment,the efficacy and adverse drug reaction were compared between two groups.Results　The total effective rate in the A group was 93.3% and the total effective rate in the B group was 67.9%.There was a statistically significant difference in total effective rate between two groups(P<0.05). There was minor adverse drug reactions in two groups.Conclusion　The therapeutic effects of mosapride and domperidone in treating PDS are good with minor adverse reactions. But mosapride is superior to domperidone in the total effective rate.]]> 2018/1/29 9:14:33 CHEN Zhi-jun, HUANG Zi-cheng, LIN Jin-gui 382true ［Abstract］　Objective　To investigate distribution and drug sensitivity of pathogenic bacteria in bloodstream infection of patients with hematologic diseases.Methods　A retrospective analysis of distribution and drug sensitivity of pathogenic bacteria from blood culture were performed on 835 patients with hematologic diseases.Results　Totally 56 strains（6.7%） of pathogens were isolated from 835 clinical blood specimens，among which there were 34 strains（60.7%） Gram-negative bacteria consisted of 15 strains Escherichia coli，9 strains Salmonella，4 strains klebsilla pneumoniae were sensitive to imipenem，ertapenem； 21 strains（37.5%） Gram-positive bacteria consisted of 9 strains coagulase negative staphylococcus，7 strains enterococus，3 strains streptococcus were sensitive to vancomycin，nitrofurantoin，compound Sul famethoxazole；1 strain fungus was monilia.Conclusion　Gram-negative bacteria was still main pathogenic bacteria in bloodstream infection of patients with hematologic diseases，which are highly resistant to antibacterial drugs. So clinical doctors should rationally select antibiotics in the treatment according to drug sensitivity results，so as to reduce and control drug resistance.]]> 2018/1/29 9:14:33 QIN Ling，WANG Mu-yun，WANG Li-e 381true ［Abstract］　Objective　To discuss the changes of pulse pressure(PP) and metabolic syndrome(MS)-related indexes in patients with nonalcoholic fatty liver disease.Methods　The data of laboratory examination and the clinical changes in 167 cases of nonalcoholic fatty liver disease(fatty liver group) with those of the control group were compared.Results　The mean arterial pressure(MAP), the mean body mass index（BMI）, PP,waist circumference（WC）and waist to height ratio(WHtR) were significantly higher in fatty liver group than those in control group（P<0.05或<0.01）; while the cases accompanied with hypertension, hyper blood glucose, hyperlipidemia and MS were increased significantly too (P<0.01).Conclusion　The patients with nonalcoholic fatty liver disease often accompany with metabolic abnormity. Controlling those risk factors and keeping within limits of fatty liver development would be available to prevent organ function damages.]]> 2018/1/29 9:14:33 WANG Xi-chuan, HUANG Ying, WU Lu-ping, et al. 380true ［Abstract］　Objective　To investigate the changes of serum homocysteine(HCY)，cystatin C(CysC) and N-terminal probrain natriuretic peptide precursor(NT-proBNP) in patients with coronary heart disease and its clinical significance.Methods　Hitachi 7100 automatic biochemical analyzer and FIA8000 immunoassay analyzer were used to detect serum levels of HCY, CysC and NT-proBNP in 52 cases of coronary heart disease patients and 52 cases of healthy volunteers, and the results were statistically analyzed.Results　Content of serum HCY and CysC and NT-proBNP in patients with coronary heart disease were significantly higher than those in healthy individuals(all P<0.01). Between myocardial infarction group and no myocardial infarction group there were a statistically significant difference in level of Hcy and NT-proBNP(P<0.05 or P<0.01),but there was no statistical significance in level of CysC(P>0.05).Conclusion　Combined detection of serum HCY, CysC and NT-proBNP levels, has a ceitain guiding significance for clinical diagnosis and treatment of coronary heart disease.]]> 2017/12/25 16:02:34 HUANG Xin-gen, ZENG Fang-lan, WU Mei-xiang 379true ［Abstract］　Objective　To study the application effect of TP regimen and IP regimen in the treatment of non small cell lung cancer.Methods　One huerdred and thirty-six patients with non small cell lung cancer were randomly divided into TP group（n=68） and IP group（n=68).TP group was treated with paclitaxel plus cisplatin, IP group was treated with irinotecan plus cisplatin, 21 days for 1 cycle for 3 cycles.Results　In TP group, there was CR16 cases, PR15 cases, SD22 cases, PD15 cases, In IP group there was 17, 13, 25, 13 cases respectively.There was no statistically significant difference in clinical efficacy before two groups(P>0.05), the main side effects in TP group and IP group was the blood system toxicity, there was no significant difference between two groups(P>0.05).Conclusion　TP and IP regimen in the treatment of non small cell lung cancer have precise clinical efficacy, better efficacy and safety.There was no obvious difference between two groups,and it is necessary to chose the chemotherapy regimens according to the characteristics of individual patient.]]> 2017/12/25 16:02:34 FENG Wen-shuai 378true ［Abstract］　Objective　To observe the clinical efficacy and safety in the treatment of cerebral infarction by Dengzhan Xixin Injection.Methods　Sixty patients with cerebral infarction were divided into observation group(n=30) and control group(n=30).On the basis of conventional treatment thirty patients in observation group were treated by Dengzhan Xixin Injection, thirty patients in control group were treated by PSS injection, The treatment course was 25 days. At the end of treatment, comparative analysis of hemorheological indices and curative effect were compared.Results　The curative effect of observation group was better than that in the control group（P<0.05）,and levels of hemorheological indices such as plasma viscosity, whole blood viscosity at high or low sheer rate, in observation group were better than those before treatment or in control group（P<0.05）.Conclusion　Dengzhan Xixin Injection treatment for cerebral infarction is the safety and effective, and can significantly improve the hemorheological indices.]]> 2017/12/25 16:02:34 YANG Fu-hai, ZHONG You-an 377true ［Abstract］　Objective　To explore the clinical characteristics and treatment of hypertension in the elderly.Methods　From June 2011 to December 2012, 180 elderly inpatients with essential hypertension were randomly selected as observation group, 100 young and middle-aged patients with high blood pressure at the same period were randomly selected as control group, and the clinical characteristics were compared between two groups.Results　There were statistically significant differences in the clinical manifestations, metabolic disorder of sugar and lipid, pulse pressure, blood pressure fluctuations, blood pressure circadian rhythm, accompanying disease and complications, orthostatic hypotension, and antihypertensive drugs between two groups(P<0.01).Conclusion　The hypertension in the elderly has following characteristics such as: higher systolic blood pressure, increases of pulse pressure, larger blood pressure fluctuations, easy to appear orthostatic hypotension, disappear of blood pressure circadian rhythm, more accompanying diseases, more complications and so on, and the treatment plan should be made according to elderly pathophysiologic characteristics and individual differences.]]> 2017/12/25 16:02:34 WANG Min-chen, YANG Xiao-qing 376true ［Abstract］　Objective　To investigate the clinical significance of interleukin-9（IL-9） in acute cerebral infarction.Methods　The serum IL-9 and CRP levels in 75 cases of acute cerebral infarction in the case group and in 50 healthy cases in control group were tested by enzyme linked immune sorbent assay(ELISA).The differences in IL-9 and CRP between two groups, and between the small area cerebral infarction and large area cerebral infarction were compared, and the relationship between IL-9 and CRP was analyzed.Results　IL-9 and CRP levels in serum the case group were significantly higher than those in control group(P<0.01);the serum IL-9 and CRP levels in cases of large area infarction were higher than those in cases of small area infarction(P<0.01);There was a positive correlation between serum IL-9 and CRP level（r=0.896, P=0.000）.Conclusion　IL-9 may participate in the occurrence and development of acute cerebral infarction, and its mechanism may be related to the IL-9 mediated inflammatory reaction.]]> 2018/1/2 8:38:52 QIU Hong-bing,LIANG Han-jin，YUAN Xue-jin, et al. 375true ［Abstract］　Objective　To evaluate the efficacy and toxicity of the combination of S-1 capsule and oxaliplatin in the treatment of advanced gastric cancer.Methods　Sixty patients with advanced gastric cancer were divided into two groups:the treatment group(30 cases) and the control group(30 cases).The treatment group were treated with S-1 capsule and oxaliplatin and the control group with oxaliplatin, calcium folinate and fluorouracil.All patients received at least four cycles of chemotherapy.Results　The treatment group showed CR in zero patient,PR in 19 patients，SD in 10 patients and PD in 1 patients,while the control group showed CR in zero patient，PR in 9 patients，SD in 17 patients and PD in 4 patients.The main side effects were hematological toxicity,gastrointestinal reaction and nervous system toxicity.Compared with the control group, the occurrence rate of adverse reactions of the treatment group were significantly lower(P<0.05).Conclusion　S-1 capsule combined with oxaliplatin is safe and effective in the treatment of advanced gastric cancer.]]> 2018/1/2 8:38:52 XIA Bao-jun, HUANG Zhi-hu, REN Wu 374true ［Abstract］　Objective　To investigate the risk factors of hospital-acquired pneumonia in acute cerebral infarction patients.Methods　Using retrospective study method,726 acute cerebral infarction patients treated were enrolled as research subjects. And the risk factors of hospital-acquired pneumonia were analyzed.Results　There were 41 cases suffered hospital-acquired pneumonia in all 726 acute cerebral infarction patients，with the incidence rate of 5.65%.Logistic regression analysis showed that age，number of basic diseases,invasive operation, NIHSS score,duration of hospitalization and use of antibiotics were independent risk factors of hospital-acquired pneumonia in acute cerebral infarction patients.Invasive operation (50=6.763) is the highest risk.Conclusion　The incidence rate of hospital-acquired pneumonia in cerebral infarction patients was influenced by many factors.According to the different risk factors, targeted intervention measures can reduce the occurrence rate of hospital acquired pneumonia.]]> 2018/1/2 8:38:52 LAI Feng-yun 373true ［Abstract］　Objective　To observe the effectiveness and safety of the Cook balloon catheter versus oxytocin in labor induction at term.Methods　Sixty pregnant women at term hospitalised in obstetric department of our hospital were randomly divided into 2 groups: the Cook balloon catheter group(30 cases) and oxytocin group(30 cases).The improvement of cervical conditions was compared before and after the application. The labor time，fetus delivery method and time，conditions of maternal and newborn health were compared between two groups.Results　The cervical Bishop score was significantly higher after applying the Cook balloon catheter (P<0.05). Compared with the oxytocin group, the time from application to labor and the time from labor to delivery in the Cook group were shorter（P<0.01）, the natural childbirth rate was higher in Cook group，and the differences were significant (P<0.05).Conclusion　Application of the Cook balloon catheter is effective and safe in labor induction at term.]]> 2018/1/2 8:39:31 SU Ling-chun, YU Lin 372true ［Abstract］　Objective　To study the clinical value of RBP, PA, TBA, CHE in different types of liver disease.Methods　The levels of RBP, PA, TBA, CHE, alanine aminotransferase(ALT), aspartate aminotransferase(AST) in 110 patient with different types of liver disease were detected respectively by automatic biochemistry analyzer to observe changes in different liver disease groups, and 68 healthy persons(control group) were analyzed at the same time.Results　The levels of RBP, PA in severe hepatitis group, cirrhosis and liver cancer groups were significantly lower than that in healthy controls (P<0.01). The TBA levels in 5 groups of patients with liver disease was significantly higher than that in healthy controls(P<0.01). But the cholinesterase activity in severe hepatitis, cirrhosis and liver groups were significantly lower than that in the control group(P<0.01). The activity of ALT and AST in acute viral hepatitis, severe hepatitis groups were increased significantly.Conclusion　It is suggested that detecting the levels of RBP, PA, TBA, CHE has some clinical significance for the diagnosis, treatment, and prognosis of liver disease, and is better than of detecting ALT, AST in the reflect the liver substantive lesions. Detection combined with RBP, PA, TBA, CHE can better reflect liver function.]]> 2018/1/2 8:39:31 YAO Bi-wan 371true ［Abstract］　Objective　To investigate the clinical effects of leflunomide combined with tripterygium glycosides and low-dose prednisone in the treatment of refractory nephrotic syndrome in middle and elderly patients.Methods　Sixty patients with refractory nephrotic syndrome treated in the affiliated hospital of Xuzhou medical college were chosen as the research object.They were randomly divided into the treatment group with of 32 patients and the control group with 28 patients.The treatment group was treated with leflunomide combined with Tripterygium glycosides and low-dose prednison and the control group was treated with cyclophosphamide(CTX) and prednisone.The clinical effects changes in biochemical markers and the incidence rate reactions between the two groups were compared.Results　After treatment，the total effective rate 81.25% in the treatment group was significantly higher than the total effective rate(67.86%) in the control group(P<0.05).After treatment for 3 months or 6 months，there were statistically significant differences in the levels of hemoglobin，urine protein，serum albumin，serum creatinine between two groups(P<0.05).The incidence rate of adverse reactions(9.38%) in the treatment group was significantly lower than that(35.71%) in the control group（P<0.05）.Conclusion　The effect of leflunomide combined with tripterygium glycosides and low-dose prednisone in the treatment of refractory nephrotic syndrome in the middle and elderly patients is exact and safe.]]> 2018/1/2 9:44:23 JIANG Gan-ru 370true ［Abstract］　Objective　To observe the effect of electrical stimulation biofeedback feedback therapy and vaginal dumbbell training on pelvic floor muscle function recovery of postpartum women.Methods　One hundred and eighteen postpartum women were divided into the observation group(60 cases) and control group(58 cases). The control group received vaginal dumbbell training, observation group received electrical stimulation biofeedback therapy on the basis of vaginal dumbbell training.Pelvic floor muscle function recovery in the two groups were observed before and after treatment.Results　After rehabilitation treatment, pelvic floor muscle strength in two groups recovered to different extent. Curative effect in the observation group was better than that in the control group, the difference was significant(P<0.05).Conclusion　Electrical stimulation biofeedback therapy and vaginal dumbbell training can improve postpartum pelvic floor muscle function.]]> 2018/1/2 9:44:23 ZHOU Bi-hua 369true ［Abstract］　Objective　To explore the diagnosis value of high resolution spiral CT scan in fracture of the skull base.Methods　Fifty-seven patients with clinically suspected skull base fracture received conventional CT scanning first, then received high resolution spiral CT scanning, and the result analysis were compared.Results　In 57 patients, 45 cases of fracture of the skull base were detected by high resolution spiral CT scan, 10 cases were detected by conventional CT scanning, showing significant difference between two methods(P<0.01).Conclusion　Spiral CT high-resolution technique significantly increase the detection rate of the fracture of the skull base, and has important guiding significance to the clinical treatment, should be used as a routine examination method.]]> 2018/1/2 9:44:23 XU Zhu-rong 368true ［Abstract］　Objective　To investigate the influence factors of the urine microprotein in the patients of Graves disease(GD) before and after cure with ¹³¹iodine(¹³¹I).Methods　Twenty patients with GD were treated with ¹³¹I and 20 healthy person were used for normal control group(NG).The patients with GD were divided into GD group(before treatment with ¹³¹I), R3M group(3 months after of cure with ¹³¹I and R12M group(12 months after cure with ¹³¹I). The following biomakers were observeed in the above groups: 3 free thyroid functions［free three triiodothyronine(FT₃), free thyroxine(FT₄) and thyroid stimulating hormone(TSH)］, thyrotropin receptor antibody(TRAb), urinary microalbumin(Alb), urine immunoglobulin(IgG) and urine β₂-microglobulin(β₂-MG) were measured by automatic chemical immune chemiluminescence. Serum high sensitivity C-reactive protein(hS-CRP) was detected by the scattering ratio.D-dimer was examined with Rate Nephelometry.And the total glomerular filtration rate(TRGFR) was calculated by SPECT.Results　There was a significant difference in 3 free thyroid functions in GD group compared with those in R3M group, R12M group and in NG(P<0.01). A significant difference of TRAb, urine Alb and IgG was observed in the GD group and R3M compared with those in R12M and in NG(P<0.01). Linear correlation analysis showed that there was significant positive correlation between FT₃ and Alb, IgG(r respectively were 0.64, 0.72, P all <0.01), TRAb was significantly positive correlated with Alb, IgG(r respectively were 0.66, 0.56, P all <0.01).Conclusion　The kidney damage of GD occurs in the glomerulus and it is closely related to immune disorders. The disappearance of the hyperthyroidism-related antibodies can be used as the effect reference index in the assessment of recovery and treatment of GD renal damage.]]> 2018/1/2 9:44:48 LI Ni, LU Gui-nan, SUN Ze-yong, et al. 367true ［Abstract］　Objective　To study the diagnostic value of restructuring optimization technology in coronary heart disease(CHD) patients with high heart rate and heart rate fluctuations.Methods　According to the degree of heart rate and the range,196 CHD patients were divided into 4 groups and examined by 64-slice CT.According to restructuring optimization technology,the valuable rate of each coronary artery between groups were compared.Results　After automatic restructuring,there were statistically significant difference in the evascular image quality between 4 groups(P<0.01), the image quality of group A was better than that of the other 3 groups(P<0.01); After again restructuring, the vascular image quality of left circumflex branch and right coronary artery between 4 groups were significant difference(P<0.01). After again restructuring optimization and automatic, the evaluable rates between groups B, C, D were statistically significant difference(P<0.05 or P<0.01).Conclusion　64-slice CT restructuring optimization technology can effectively increase the evaluable rate of video image, but there are still certain limitation and the insufficiency, and the effective control of heart rate and heart rate fluctuations before examination can improve the evaluable rate and the diagnostic rate.]]> 2018/1/2 9:44:48 ZU Xiao-hong 366true ［Abstract］　Objective　To evaluate the efficiency of conventional mechanical ventilation(CMV) and high-frequency oscillatory ventilation(HFOV) in the treatment of neonates meconium aspiration syndrome(MAS).Methods　Sixty neonates with MAS were randomly divided into CMV group（30 cases） and HFOV group（30 cases）. The parameter of pH, PaO₂, PaCO₂, FiO₂(inhaled oxygen concentration),OI(oxygen index) were monitored before and after mechanical ventilation.Complications and clinical outcomes were compared.Results　The pH, PaO₂, PaCO₂, FiO₂, OI at 0 h between the two groups were not statistically significant difference(P>0.05).At 2 hours, 12 hours, 24 hours,48 hours after ventilation, pH, PaO₂, PaCO₂, FiO₂, OI in the HFOV group improved more quickly than those in the CMV group, with statistically significant difference(P<0.05). Mechanical ventilation time in the HFOV group was more shorter than that in the CMV group, with statistically significant difference(t=3.197,P=0.002). The complications of mechanical ventilation hade statistically significant difference between two groups(χ²=4.043,P=0.044). The cure rate had statistically significant difference between two groups(χ²=4.320,P=0.038).Conclusion　HFOV is a safe and effective means for the treatment of severe MAS.]]> 2018/1/2 9:44:48 FENG Cheng-fang, LIAO Pei-guang 365true ［Abstract］　Objective　To observe the clinical effect of sequential invasive and non-invasive mechanical ventilation in treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) combined with type Ⅱ respiratory failure.Methods　Sixty-four patients with AECOPD combined with type Ⅱ respiratory failure in our hospital were randomly selected and divided into two groups. On the basis of routine treatment,32 patients in the treatment group were given sequential non-invasive ventilation and another 32 patients in the control group were given convention ventilation respectively. The main ventilation index were compared.Results　Compared with the control group，the total ventilation time was significant shorter and the incidence of ventilator-associated pneumonia(VAP) was significant lower in the treatment group（P<0.05）.Conclusion　The sequential invasive and non-invasive ventilation in treatment of AECOPD combined with type Ⅱ respiratory failure has better clinical effect, shortening the total ventilation time and reducing the incidence of VAP.It is of certain clinical value and is worth popularizing.]]> 2018/1/2 9:44:48 CHEN Zhan-wei 364true ［Abstract］　Objective　To explore the effect of microwave technique under choledochoscope for treatment of bile duct wall diseases.Methods　Seventy-one patients with bile duct wall disease(bile duct stricture, bile duct polypi, polypus-like pathological changes of bile duct, bile duct tumor) were treated with microwave technique under choledochoscope. The power of microwave for treatment of bile duct stricture was 50～90 W. The stricture sites were enlarged by multi-points coagulation and rad cauterization to char or gasify the membrane-like hyperplastic tissues. For treatment of bile duct polypi, polypus-like pathological changes of bile duct and bile duct tumor which first underwent biopsies to rule out cancerization, the power of microwave was generally 90～110 W. During the operation, the radiation head was usually inserted into polypi foci to make local tissue white-looking and charring then.Results　Totally 37 sites in 33 cases of bile duct stricture and 47 sites in 44 cases of bile duct polypi, polypoid lesions of bile duct and bile duct tumor underwent microwave treatment in choledochoscopic examination. The bile duct strictures took a favorable turn and the retained stones were removed as a result, which were verified by T-tube visualization to show an improved image of bile duct tree. In addition, the polypi foci disappeared gradually. No complication like bleeding or perforation occurred during the treatment in all the patients, and the choledochoscope was intact after use, keeping a fine condition as before.Conclusion　The microwave technique under choledochoscope for treatment of bile duct disease brings into full play of the both and expands the application of the both, thus it is a novel, safe and effective technique, which is valuable for generalization.]]> 2018/1/8 8:50:20 MA Li-lin， ZHU Jian-wei， WANG Wei， et al. 363true ［Abstract］　Objective　To provide the information supporting and basis for preventing oral disease of university entrants through the survey of oral health status in university entrants.Methods　Nine hundred and sixty entrants were investigated by the questionnaire of oral health status in 2009. The questionnaire referreed the scheme of national oral epidemiological survey.Results　The prevalence rates of dental caries, gingivitis, dental calculus, oral ulcer, tooth defect in entrants were 62.1%, 55.0%, 48.1%, 18.1% and 14.2% respectively. The caries incidence in girls(71.3%) was significantly higher than that of boys(56.2%)(P<0.01).The prevalence rates of gingivitis, dental calculus, oral ulcer and tooth defect in boys were significantly higher than those of girls(P<0.05).Sexuality, whether or not brushing in the morning and evening, whether brushing time< 2 min, whether bedtime snacks, whether regular oral examination and urban or rural areas were the main influencing factors of university freshmen′s oral health(P<0.01).Conclusion　The oral health status of university entrants is not optimistic, we should carry out the oral health education, popularize the oral health knowledge and practice oral health behavior in university entrants, to improve the students′ oral health.]]> 2018/1/8 8:50:20 LI Chun-feng,WAN Xiao-man,YANG Xiao-ying 362true ［Abstract］　Objective　To investigate the safety and efficiency of percutaneous nephrolithotripsy with Cyberwand dual probe lithotriptor and holmium laser lithotomy for treatment of complicated renal calculi.Methods　The clinical data of 61 patients of complicated renal calculi in our hospital from Mar 2011 to Oct 2012 were retrospectively analyzed. Patients were randomly divided into 2 groups: Cyberwand dual probe lithotriptor group(n=31) and holmium laser lithotripsy group(n=30).Results　The pereutaneous renal access was successfully established in all patients under ultrasound guidance. For Cyberwand dual probe lithotriptor group, the operation duration was（78±25）min, the blood loss was（67±20）ml, the water consumption was（19000±3000）ml, the calculus clearance rate was 87.1% and the complication rate was 9.7%. For holmium laser lithotripsy group, the operation duration was（110±32）min, the blood loss was（95±28）ml, the water consumption was（24000±4000）ml, the calculus clearance rate was 90.0% and the complication rate was 10.0%. There was a significant difference between two groups in the duration of operation, the blood loss and the water consumption(P<0.05), but no significant difference in the calculus clearance rate and the complication rate(P>0.05).Conclusion　Both percutaneous nephrolithotomy with Cyberwand dual probe lithotriptor and holmium laser lithotripsy for treatment of complicated renal calculi were safety and efficiency.The percutaneous nephrolithotomy with Cyberwand dual probe lithotripter has the advantages of high reliability and rapid recovery, which reduce the risk of developing bacteremia or septicemia.]]> 2018/1/8 8:50:20 YANG Jian-xin, WU Xi-qing, BAI Gang, et al. 361true ［Abstract］　Objective　To explore the clinical efficacy of targeted treatment measures for children with severe hand-foot-mouth disease(HFMD).Methods　On the basis of the mational standard for diagnosis and treatment of HFMD in the treatment group, 138 children with severe HFMD hospitalized in our hospital in 2012 were treated by targeted treatment measures; in the control group 152 children with severe HFMD were not treated by targeted treatment measures, and the clinical efficacy between two groups were retrospectively compared.Results　The disease exacerbation rate in the treatment group was lower than that in the control group(P<0.01), but the rescue success rate and case fatality rate were similar between the two groups(P>0.05);the symptems disappearing time and length of hospital stay and breathing machine utilization rate in the treatment group were shorter than those in the control group(P<0.05 or <0.01); the incidence of complications and sequela in the treatment group were lower than those in the control group(P<0.01).Conclusion　Targted treatment measares provide a systematic and operational scheme for treating severe HFMD,can obviously shorten the clisappearing time of clinical symptoms and hospitalizationg time,reduce the incidence of hyperglycemia and the sequela of the nerves system,and improve the prognosis.]]> 2018/1/8 8:50:54 LU Ji-fang, WANG Zhao-kang 360true ［Abstract］　Objective　To analyze the changes in blood pressure of obstructive sleep apnea hypopnea syndrome(OSAHS) patients before and after treatment.Methods　Two hundred and six patients complained of snoring were divided into OSAHS group(139 cases) and non-OSAHS group(67 cases) by polysomnography(PSG). All patients were monitored 24 h ambulatory blood pressure with ambulatory blood pressure monitoring, and both groups results were compared analyzed. OSAHS patients received reexamination for 24 h ambulatory blood pressure before treatment and after 6 months later, and the results were compared.Results　The incidence of hypertension in OSAHS group were significantly higher than in non-OSAHS group(P<0.05). The blood pressure of patients with OSAHS showed often a nondipper pattern. Followed-up of 6 months showed after effective nCPAP, surgery and other treatment, blood pressure in OSAHS patients had descendent tendency.Conclusion　After effective treatment, blood pressure of OSAHS patients tends to be normal, and can prevent and reduce cardiovascular events.]]> 2018/1/8 8:50:54 WEI Hua-qing, WEI Cen 359true ［Abstract］　Objective　To investigate the value of multislice CT in the diagnosis of airway foreign bodies.Methods　Fifty-six patients with suspected airway foreign body were given multislice CT examination, and their examined results were contrastod with the results obtained by bronchoscopy.Results　Multislice CT examination detected airway foreign body in 52 patients, 1 case was misdiagnosed as pneumonia, and the foreign body was removed by bronchoscope examination; Between multislice CT and bronchoscope there was no statistically difference in foreign body detection rate(χ²=0.61, P>0.05); With bronchoscope examination results as the gold standard, spiral CT sensitivity was 96.23%, the diagnostic coincidence rate was 96.64%.Conclusion　Multislice CT examination for airway foreign bodies have the characteristics of high sensitivity, high coincidence rate, but also should be combined with the history, clinical signs, in order to reduce the incidence of misdiagnosis, missed diagnosis. For children, multislice CT examination should be penformed at the lowest dose scanning, in order to avoid radiation damage.]]> 2018/1/8 8:50:54 JIN Qin-jian, ZENG Shao-liang, ZU Xiao-hong 358true ［Abstract］　Objective　To investigate the incidence and treatment of drug alletgy(DA) in our hospital in 2012.Methods　One hundred and forty-seven cases of DA in our hospital during 2012 were retrospectively analyzed.Results　There were 79 cases of systemic reaction(53.7%) including 6 cases of allergic shock, 68 cases of skin reaction(46.3%). The fist three drugs resulting in DA included antibiotics, antineoplastic drugs and traditional Chinese medicine injection.The DA was characterized by acute onset and severe symptoms;The DA incidence of intravenous medication was the highest. The DA incidence of oral and topical medication was lower,the DA was characterized by slower onset and milder symptoms. By stopping(or changing) drugs. anti-allergic therapy hormone, symptomatic treatment, the symptoms can be alleviated or disease condition got better; 6 cases of allergic shock also were cured.Conclusion　It is necessary to strengthen the management of traditional Chinese medicine injection agent, antibiotiotis and antineoplastic drugs, pay close attention to the medication process of patients, timely detect and treat DA,in order to ensure the safety of patients in medication process.]]> 2018/1/8 8:50:54 WU Wei 357true ［Abstract］　Objective　To explore the value of high-sensitive C-reactive protein(hs-CRP) in the diagnosis and treatment of ischemic stroke.Methods　One hundred and twenty cases of ischemic stroke were selected as the disease group, and according to the different levels of infarction, those cases were divided into mild infarction group(47 cases), moderate infarction group(35 cases), severe infarction group(38 cases); Meanwhile a healthy group was set up correspondingly by selecting 120 healthy cases with their general information, such as gender, age, etc, similar to which of the disease group. hs-CRP was detected in all disease groups before and after treatment and healthy group, and their test results were compared.Results　The hs-CRP levels of the healthy group and which of the mild infarctions group, the moderate infarction group, the severe infarction group, before treatment were (3.32±0.46)mg/L,(8.87±3.72)mg/L,(18.52±6.33)mg/L,(32.51±11.25)mg/L, respectively. Evidently the hs-CRP levels of ischemic stroke patients were higher than that of healthy people, further, more severe the infarction was, higher its hs-CRP levels was. The differences of above results between the disease groups and the healthy group were significant in statistics(P<0.05). After treatment, the patients′ hs-CRP levels basically returned to normal level.Conclusion　The hs-CRP detection is high sensitive and fast. With that advantages, the method can be used in diagnosis of ischemic stroke and evaluation for its treatment effect.]]> 2018/1/8 8:50:54 HUANG Xiao-chun 356true ［Abstract］　Objective　To explore the reasons of common complications after ventriculo-peritoneal shunt in the patients with hydrocephalus and the corresponding measures of prevention and treatment.Methods　A retrospective analysis was performed on the clinical data of 19 patients with hydrocephalus who had postoperative complications of ventriculo-peritoneal shunt from April 2008 to January 2013.Results　In the 19 patients, obstruction of shunt tube appeared in 7 cases, infection in 4 cases, subdural hematoma or dydrops in 4 cases, ectopia of shunt tube in 2 cases and prolapse shunt tube from anus in 1 case. After treatment, patients′ clinical manifestation relieved in different degree. Ventriculo-peritoneal shunt was performed again in 13 patients. The reviews of head CT or MRI on 16 patients with progressive hydrocephalus showed marked improvement of hydrocephalus. In 19 cases, 18 cases were cured, 1 case died of serious intracranial infection. The effective rate was 94.7%.Conclusion　Strictly mastering indications and aseptic technique of ventriculo-peritoneal shunt for hydrocephalus, improving the operation skills, selecting shunt system individually and adopting adjustable valve shunts to young patients, can reduce the occurrence of postoperative complications.]]> 2018/1/8 8:50:54 ZHANG Yun-he, LV Shu-juan 355true ［Abstract］　Objective　To explore the diagnostic and prognostic values of combined measurements of cardiac troponin I(cTnI), C reactive protein(CRP) and B-type natriuretic peptide(BNP) in patients with ischemia heart failure.Methods　The serum cTnI, CRP and blood plasma BNP in 98 cases ischemic heart failure patients with different cardiac function classification and 95 coronary heart disease without heart failure patients, and a follow-up observation of the recurrence of recent cardiac events was performed.Results　The levels of serum cTnI, CRP and blood plasma BNP between heart failure patients with different cardiac function grading and the control group were compared, and the differences were statistically significant. The worse the heart function was, the higher the concentration was(P<0. 05). Serum cTnI, CRP and plasma BNP concentrations at hospital discharge in the cardiac events group were markedly higher than those in the non-cardiac events group(P<0. 05).Conclusion　Serum cTnI, CRP and plasma BNP concentrations in patients with congestive heart failure obviously increase, and the combined measurements of three indexes have important significance in clinical diagnosis and prognostic evaluation for heart failure.]]> 2018/1/15 8:41:56 SONG Fu-rong, SUN Hong-bin, PENG Xu-hui, et al. 354true ［Abstract］　Objective　To compare the repairing effects between the zirconia all-ceramic crown bridge and zirconia bridge in aesthetics restoration of molars.Methods　Thirty-six patients were restorated with the all-ceramic crown bridge(19 patients 66 molars) and zirconia(bridge 17 patients 60 molars), followed up for 1～3 years,checked and appraised the marginal adaptation,form,colour of the crowns,the gingiva and crown fracture by one doctor.Results　There was no statistically difference in the effects between the two kinds of restorations.Conclusion　The two kinds of restoration can meet clinical needs in the marginal adaptation，aesthetics and the flexural strength.The zirconia bridge is better in patients with shorter occlusogingival distance.]]> 2018/1/15 8:41:56 PENG Li-hui, ZHONG Ai-xi, PAN Xiao-bo,et al. 353true ［Abstract］　Objective　To study the relevance between diabetes and chronic hepatitis B with chronic cholecystitis and provide reference for the treatment of chronic hepatitis B with chronic cholecystitis.Methods　Three hundred and ninety-six patients with mild or moderate chronic hepatitis B were studied.The fasting blood glucose,2 h postprandial blood glucose,sugar tolerance in these patients were detected to screen out patients with diabetes;type- B ultrasonic examination and CT examination were performed to screen out patients with chronic cholecystitis,and the incidence of chronic cholecystitis between patients with and without diabetes were compared.Seventy-two chronic hepatitis B patients with chronic cholecystitis and diabetes were set as group Ⅰ for treatments,and 119 chronic hepatitis B patients with chronic cholecystitis without diabetes were set as group Ⅱ for treatments.The treatments for both groups were the same,and the results of the treatments were analyzed and recorded.For patients in the group Ⅰ,who did not respond to the treatments,additional insulin treatment was given,and the results of the treatments were analyzed and compared.Results　The incidences of cholecystitis in patients with or without diabetes were 100.0%(72/72) and 36.7%(119/324)respectively and the difference was significant(P<0.01).The recovery rate and the total effective rate of liver function in group Ⅰ were lower than those in group Ⅱ after the treatments(P<0.01);the total effective rate of improvement of sonographic characteristics of biliary tract in group Ⅰ was lower than that in group Ⅱ after the treatments(P<0.01).The total effective rate of insulin treatment in recovering liver function after failure of treatments in group Ⅰ was 68.3%.Conclusion　Chronic hepatitis B with chronic cholecystitis is strongly relevant with diabetes and the existence of diabetes directly affects the treatments for liver function and biliary tract,but insulin treatment can lead to good prognosis.For chronic hepatitis B patients with chronic cholecystitis,the screening of diabetes is extremely important.]]> 2018/1/15 8:41:56 LIU Hong-xia, CHEN Min, WANG Xi-ming, et al. 352true ［Abstract］　Objective　To observe the effects of compound apocynum tablets on left ventricular hypertrophy and diastolic function in elderly hypertension patients.Methods　In the treatment group， 40 elderly hypertension patients were treated with compound apocynum tablets. In the control group, 42 patients were treated with captopril. Six months after treatment,echocardiography was used for comparing the improved situation in left ventricular hypertrophy and diastolic function.Results　After treatment, blood pressure decreased significantly, left ventricular hypertrophy reversed and diastolic function improved in different degrees the patients of two groups.Conclusion　Compound apocynum is an effective and inexpensive antihypertensive drug and has effect in different degree on left ventricular hypertrophy and diastolic function.]]> 2018/1/15 8:41:56 WEI Xiao 351true ［Abstract］　Objective　To explore the clinical efficacy of edarovone combined with kailldinogenase in treating patients with progressive cerebral infarction.Methods　Ninety patients with acute progressive cerebral infarction treated in the people′s hospital of Anxi county recently were randomly divided into treatment group(45 cases) and control group(45 cases). All the patients received the routine treatment such as aspirin for anticoagulation,atorvastatin for reducing lipid,shuxuetong for improving circulation,and so on. On the basis of above treatment,the control group was treated with edarovone,while the treatment group was treated with edarovone combined with kailldinogenase. The neurological injury,blood rheology changes and clinical efficacy before and after treatment were observed and compared.Results　The clinical efficacy of treatment group was better than that of the control group(P<0.01). The neurologic deficit scale,hemorheology indexes after treatment declined significantly in two groups(P<0.05 or P<0.01),but the declined extent in the treatment group was greater than that in the control group(P<0.01).Conclusion　Edarovone combined with kailldinogenase shows good clinical efficacy in treating progressive cerebral infaretion.]]> 2018/1/15 8:41:56 ZHANG Ze-jian，FU Fei-huan,LIN Jin 350true ［Abstract］　Objective　To investgatd the safety and efficacy of the high initial concentration sevoflurane for inhalational induction of general anaesthesia.Methods　Three hundred adult patients undergoing elective surgery anesthesia, ASAⅠ～Ⅱ, were randomly divided into two groups according to odd or even number of operative date.The low initial concentration group(179 cases) was initially administered a low concentration of sevoflurane then the concentration was gradually increased until the patient was anaesthetized. The high initial concentration group(121 cases) was administered high concentrations of sevoflurane(from 4% to 8%) from the beginning, continuing until the patients was anaesthetized. Both techniques can be carried out using different breathing patterns. Time to loss of eyelash reflex(LOER)(seconds), complication rates in the two groups were recorded.Results　Time to LOER in high initial concentration group was obviously shorter than the lower initial concentration groups, the differences were statistically significant （P<0.01）.There was no difference in the incidence of adverse effects between the two groups（P>0.05）.Conclusion　Compared with low initial concentration of sevoflurane a high initial concentration sevoflurane probably offers more rapid induction of anaesthesia and a similar rate of complications, especially worth promoting.]]> 2018/1/15 8:41:56 CHEN Zu-tao,PENG Hui-li,WANG Peng 349true ［Abstract］　Objective　To evaluate the relationship of helicobacter pylori(Hp) infection with cerebral infarction in patients with primary hypothyroidism and analyze of the possible mechanism.Methods　Eighty-two cases with primary hypothyroidism were divided into two groups according to the results of Hp:Positive Hp group(n=50) and negative Hp group(n=32).The high risk factor of cerebral infarction were detected.Results　Positive Hp group showed higher C-response protein(CRP) and TG and LDL-C than the negative Hp group（P<0.01）, but lower HDL-C than the negative Hp group（P<0.05）.Conclusion　Results showed that Hp infection may be a risk factor of cerebral infarction in primary hypothyroidism.]]> 2018/1/15 8:42:20 DENG Xiao-feng, HE Cun-lan 348true ［Abstract］　Objective　To monitor the platelet-leukocyte aggregates(PLA) level in patients received surgery under general anesthesia and to explore the potential mechanism of deep vein thrombosis occurred in these patients.Methods　Blood samples were collected from 112 patients received surgery at the time:before the general anesthesia; immediately after the surgery, and 3 days after the surgery. Flow cytometry was used to measure the platelet-neutrophil aggregates(PNA) and platelet-monocyte aggregates(PMA).Results　Before the general anesthesia: PNA(19.32±3.48)%, PMA(26.86±5.05)%;Immediately after the surgery: PNA(19.48±3.20)%, PMA(31.86±5.31)%; Three days after the surgery: PNA(21.85±2.84)%, PMA(77.69±5.72)%; Statistical analysis: the PNA and PMA level in patients immediately after the surgery and that in patients three days after surgery were higher than that patients before the general anesthesia(P<0.01).Conclusion　The PNA and PMA level, especially, the PMA level in patients received surgery is affected by general anesthesia. PNA and PMA can be used as a sensitive biomarker to determine the degree of platelet activation and to predict the possible postoperative thrombosis.]]> 2018/1/15 8:42:20 WANG Sheng, LI Xin-gang，ZHAO Ji-quan 347true ［Abstract］　Objective　To explore the clinical significances of random urine protein to urine creatinine ratio in the diagnosis and treatment of kidney disease(KD).Methods　Seventy-eight patients with KD were used as experimental group,46 healthy people as normal control group.The urine protein to urine creatinine ratio and 24 h urine protein quantity in each group were detected respectively, and the statistical processing was performed.Results　There were statistically significant different in urine protein to urine creatinine ratio and 24 h urine protein quantity between two groups(P<0.01);the correlations between urine protein to urine creatinine ratio and 24 h urine protein quantity of two groups were good.Conclusion　Random urine protein to urine creatinine ratio can be used as a indicator of kidney disease screening.]]> 2018/1/15 8:42:20 LV Jun,XU Xiang,LV Mei 346true ［Abstract］　Objective　To observe the safety and anesthetic effect of dexmedetomidine combined with ketamine in pediatric ophthalmic surgery.Methods　Ninety children aged 2～7 years received ophthalmic surgery were randomly divided into 3 groups(30 cases in each group):group A: ketamine combined with dexmedetomidine；group B: ketamine and midazolam；group C:ketamine.The tested indexes were recorded before anesthesia(T0), at 5 min after intramuscular injection of ketamine(T1), at operation beginning(T2), at 5 min after operation beginning(T3), at 15 min after operation beginning(T4) and at the end of operation(T5) of SBP, DBP, HR, SpO₂. The total dosage and the occurrence of adverse reactions of with ketamine were recorded. The postoperative recovery time and agitation occurrence were observed.Results　Between group A and group C, there were significant differences in SBP at T1, T3, T5 and in DBP at T5(P<0.05). Between group A and group B, group C there was statistically significant differences in HR at T5(P<0.05). The total dosage of ketamine and the number of cases of adverse reactions in group A and group B were different from those in group C(P<0.05). The recovery time in group A and group B were less than those in group C with a significant difference between group A and group C(P<0.05). The incidence of agitation in group A was lower than those group B and group C(P<0.05).Conclusion　Anesthesia of dexmedetomidine combined with ketamine for pediatric ophthalmic surgery is safe, and has the advantages of stable hemodynamic state, less adverse reactions, lower incidence of postoperative agitation.]]> 2018/1/15 8:42:20 ZHU Cheng-yun 345true ［Abstract］　Objective　To investigate the clinical efficacy and adverse reactions of the cefoperazone sulbactam combined with levofloxacin in the treatment of hospital acquired pneumonia(HAP).Methods　Forty-two patients with HAP were randomly divided into treatment group and control group, each group with 21 patients. The treatment group was treated with cefoperazone sulbactam combined with levofloxacin and control group was treated with cefoperazone sulbactam, treatment course was 7～8 d.Results　The time of symptoms and sign returned to normal in the treatment group was (48.24±7.54)h, that in the control group was (72.36±10.24)h (P<0.01); the clinical efficacy of the treatment group was better than the control group(P<0.05), incidence of adverse reactions was not statistically significant between the two groups(P>0.05).Conclusion　The efficacy of cefoperazone sulbactam combined with levofloxacin in the treatment of HAP is significantly better than cefoperazone sulbactam, and this combined use is worthy of promotion.]]> 2018/1/15 8:42:20 ZHOU Jia-jie,DENG Yong-bin ,LIU Wei-ling 344true ［Abstract］　Objective　To explore the application value of 64 row-128 slice volume CT coronary angiography in the diagnosis of coronary heart disease.Methods　One hundred and seventeen cases of coronary heart disease were selected,the 64 row-128 slices volume CT coronary angiography were used to display the coronary artery lesions in diagnosis of coronary artery main branches and the branches,and its accuracy in the diagnosis of different parts of coronary artery lesions and the sensitivity and the specificity in the diagnosis of different degree of stenosis were analyzed.Results　The coronary artery angiography test results showed:the left anterior descending artery lesions in 54 cases;left main coronary artery lesions in 48 cases;double branch lesions in 32 cases; left circumflex artery lesions in 28 cases; right coronary artery lesions in 25 cases. The detection sensitivity reached 91.38%, and the accuracy reached 92.51%; the sensitivity and specificity for different degrees of coronary artery narrow were the higher.Conclusion　64 row-128 slice volume CT coronary angiography in the diagnosis of coronary heart disease, because of its use of noninvasive technique and higher sensitivity and specificity, has good application value in the clinical diagnosis of coronary artery disease.]]> 2018/1/15 8:42:20 LIU Rong-hua, XU Yu-chong 343true ［Abstract］　Objective　To explore the clinical significance of IL-6 in the development of acute pancreatitis with acute lung injury.Methods　Ninety-six acute pancreatitis patients were divided into acute panccreatitis group and acute panccreatitis with acute lung injury group randomly,and thirty healthy adults were selected as the control group. IL-6 was defected by radioimmunoassay and chemiluminescence, then the changes of IL-6 was analyzed statistically.Results　The levels of IL-6 in acute panccreatitis group and acute panccreatitis with acute lung injury group were higher than that in the control group, the leves of IL-6 in acute pancreatitis with acut lung injury group was higher than that in acute pancreatitis group,all had statistical significance(P<0.05).Conclusion　As an inflammation factor,IL-6 participates in the pathophy siological process of acute pancreatitis with acute lung injury.]]> 2017/12/18 8:27:35 WANG Jing, REN Li-mei, MENG Xian-mei, et al. 342true ［Abstract］　Objective　To evaluate the role of motherwort injection(yimucao zhusheye) for preventing postpartum hemorrhage and promoting the uterine involution after cesarean section.Methods　There hundred and sixty women at the gestational age of more than 28 weeks who received the cesarean section were divided randomly into the treatment group(180 cases) treated by motherwort injection combined with oxytocin and control group(180 cases) treated by oxytocin. Amount of bleeding during the operation and after operation, the number of cases of postpartum hemorrhage, uterine contraction at different periods,involution of uterus and hemoglobin decline after operation were observed.Results　Amount of bleeding at every period in control group were significantly more than that in treatment group,there were statisticant differences（P<0.05）. Uterine contraction at different periods in treatment group were all better than that in control group, there were statisticant differences during the operation, at 2 h and 6 h after operation（P<0.05）.The falling height of the uterus at 3d and 5d between two groups were statisticant differences（P<0.05）. Compared with hemoglobin levels before operation, there were statisticant differences in hemoglobin decrease degree at <1 g/L, 1 ～ 2 g/L,>2g /L（P<0.05） after operation between two groups.Conclusion　Motherwort injection combined with oxytocin is useful for preventing postpartum hemorrhage and promoting uterine involution after cesarean section,which can be used as the preferred treatment for postpartum hemorrhage and uterine contraction.]]> 2017/12/18 8:27:35 GAO Ya-hong 341true ［Abstract］　Objective　To investigate the composition of pathogenic bacteria and drug resistance of common pathogenic bacteria in hospitalized patients with community acquired pneumonia(CAP) in the winter of 2013 in our hospital,and provide the basis for the diagnosis and empirical therapy of CAP.Methods　The clinical data and etiological data of 108 CAP patients were analyzed in the hospital from Oct.2013 to Mar.2014 by retrospective research methods.Results　In 128 sputum specimens from 108 CAP patients, 64 strains pathogenic bacteria were detected, the detection rate was 50.0%,with klebsiella pneumoniae and candida albicans as the first two strains. The sensitivity of klebsiella to carbapenems, the third generation cephalosporins and quinolones was higher. The drug resistance of klebsiella pneumoniae to the first generation and second generation cephalosporins and macrolides was higher.Conclusion　Pathogens of acquired pneumonia in winter mainly is gram-negative bacteria, and the most common is klebsiella pneumoniae. For the eldly patients suffered from basic diseases such as chronic obstructive pulmonary disease or bronchiectasis disease and so on, the therapy of anti-gram-negative bacteria should be paid attention to.]]> 2017/12/18 8:27:35 ZHANG Yu 340true ［Abstract］　Objective　To investigate the efficacy of treatment of acute left ventricular failure by non-invasive positive pressure ventilation(NIPPV).Methods　Sixty-four patients with acute left ventricular failure were randomly divided into the observation group(n=32) and the control group(n=32).The control group was treated by conventional therapy，including oxygen inhalation，strengthening myocardial contraction，diuresis，vasodilator and so on; the observation group was treated by NIPPV on the basis of conventional therapy.The changes in heart rate, respiration,blood pressure, blood oxygen saturation and the heart function were observed before treatment, at 24 hours and 72 hours after treatment，respectively.Results　At 24 hours after treatment, the total effective rate in the observation group was higher than that in the control group(93.75% vs 71.87%).At 72 hours after treatment the improvement in PaO_CI, PaCO_CI, pH, BNP in the observation group were significantly better than that in the control group, the difference was significant(P<0.01).Conclusion　NIPPV combined with conventional therapy can significantly improve symptoms of patients with acute left ventricular failure，and save the life of patients.]]> 2017/12/18 8:27:35 LI Jun 339true ［Abstract］　Objective　To investigate the advantages and complications of laparoscopic ventriculo-peritoneal shunt for hydrocephalus.Methods　A retrospective analysis was performed on the clinical data of 39 patients with hydrocephalus treated by laparoscopic ventriculo-peritoneal shunt.Results　Thirty-eight patients were followed up for 3 months to 1 year, one of them lost follow-up because telephone number replacement. Symptoms fully disappeared in 26 cases, symptoms significantly improved in 8 cases, symptoms did not significantly improved in 4 cases. Postoperative complications occurred in 6 cases(15.4%), including: shunt tube obstruction in 2 cases, epilepsy in 1 case, infection in 1 case, subdural hematoma in 1 case, intraventricular hemorrhage in 1 case.Conclusion　Laparoscopic ventriculo-peritoneal shunt for hydrocephalus has advantages of less trauma, safe, fast, exact effect and less complications such the drainage tube clogging, wrapped, infection, intestinal obstruction and worthy of popularizing.]]> 2017/12/19 8:06:01 YANG Chun-hong, XU Dong-chu, YANG Feng-zhong 338true ［Abstract］　Objective　To investigate the therapeutic effect of xuesaitong injection powder, low molecular dextran combined with ganglioside in the treatment of acute cerebral infarction.Methods　Ninety-eight patients with acute cerebral infarction were randomly divided into two groups,the treatment group(n=57) was treated with xuesaitong injection powder, low molecular dextran combined with ganglioside; the control group(n=41) was treated with salvia miltiorrhiza ligustrazine, citicoline, venoruton injection,the course of treatment was 14 days.Results　The clinical efficacy of the treatment group was better than that of the control group(P<0.05), the reducing degree of neurological deficit scores in the treatment group was significantly more than that in the control group(P<0.01), there was no significant side effects in the treatment.Conclusion　Xuesaitong injection, low molecular dextran combined with ganglioside in the treatment of acute cerebral infarction is a kind of safe and effective therapeutic method and is worthy of promotion.]]> 2017/12/19 8:06:01 WANG Yun-bing 337true ［Abstract］　Objective　To investigate the expression of P21^WAF1 in human gastrointestinal stromal tumors(GIST).Methods　Fifty cases of GIST were evaluated for P21^WAF1 protein expression by immunohistochemical method.Results　The positive expression level of P21^WAF1 was 48.0% in human GIST,which was lower than in the adjacent tissues（76.2%）.Conclusion　P21^WAF1 is related to GIST, and can be used as a supplemental index of CD117. It is helpful for the diagnosis of GIST.]]> 2017/12/19 8:06:01 GU Guo-jian，GU Feng-hua，LIAN Ling-zhi 336true ［Abstract］　Objective　To investigate clinical effects and adverse reactions of Kaihoujian sprays(child type) combined with Reduning injection in treating children with herpangina.Methods　One hundred children with herpangina were divided into two groups. Fifty-five patients served as treatment group were given Reduning injection intravenously. Forty-five children regarded as the control group were given Watermelon frost sprays, which is widely used in local treatment and Ribavirin injection intravenously,for a full period of 5～7 days, and were given local kaihoujian sprays combined with conbi a supportive treatment according to the conditions of the disease. The observation indexes of the clinical efficacies and the clinical curative effect, and adverse reactions were compared between the two groups.Results　The treatment group was 30 cases of significant effect, effective 20 cases, invalid in 5 cases; 20 cases of control group were significant effect, 15 cases were effective, 10 cases ineffective， there was no statistically significant difference between the two groups in curative effect(P>0.05). But defervescence time, mouth pain disappearing and Herpetic ulcer healing in treatment group was considerably better than the control group, the difference was statistically significant(P <0.01). The total number of white blood cells or the ratio of neutrophils decreased in 18 patients in the control group. There was no adverse reactions in treatment group.Conclusion　Therapeutic effect of Kaihoujian sprays(child type) combined with Reduning injection in treating children with herpangina is significant, which is safety.]]> 2017/12/25 16:01:51 HUANG Shao-ling 335true ［Abstract］　Objective　To summarize the experience of surgical treatment of valvular heart disease in elderly patients.Methods　The clinical data of 142 elderly patients over 65 years old received cardiac valve replacement with cardiopulmonary bypass were retrospectively analyzed.Results　Twelve cases died, the mortality was 8.45%.One hundred and thirty cases were followed up for 3～36 months, no patients died.Conclusion　To improve the operation skills and perioperative treatment, elderly patients undergoing cardiac valve replacement is safe and can achieve satisfactory effect.]]> 2017/12/25 16:01:51 CAI Xiao-bi, CHEN Lin, Lin Li-yao, et al. 334true ［Abstract］　Objective　To explore the screening methods and the related factors of mild cognitive impairment(MCI) in patients with Parkinson′s disease(PD).Methods　Montreal Cognitive Assessment(MoCA)(Beijing Version) was used as cognition assessment implement. Thirty-eight PD patients with mild cognitive impairment were chosen as research group(MCI group), and 30 PD patients with normal cognitive function was chosen as control group. In all subjects the creatinine（CREA）, Triglyceride(TG), cholesterol（CHOL）, high density lipoproteins（HDL-C）, alanine transarninase(ALT), glutamic-oxalacetic transaminase(AST) was measured.Results　(1)Between MCI group and control group: there were significant differences in the duration of PD,BMI,abdominal perimeter,LDL-C,HDL-C, CHOL(P<0.05） and no significant differences in TG,ALT,AST and CREA.(2)There was negative correlation between the MoCA scores and the LDL-C in MCI group(r=-0.255,P<0.05).Conclusion　The risk factors such as longer duration, obesity and high level of blood fat contribute to the development of cognitive impairment and may even aggravate it. So reduction of body weight and control of blood fat may help to improve the cognitive function.]]> 2017/12/25 16:01:51 ZHANG Ze-jian, FU Fei-huan, ZHENG Ru-mei, et al. 333true ［Abstract］　Objective　To study the stir and pain prevention and treatment effect by dezocine of the acute calculus incarcerated cholecystitis patients treated by laparoscopic cholecystectomy during the awakening period.Methods　80 patients with acute calculus incarcerated cholecystitis treated in the general surgery department from June 2012 to June 2014 were selected as the research subjects. All patients who were performed by laparoscopic cholecystectomy were divided into the control group and the observation group. The control group was given 1 μg/kg fentanyl by intravenous drip and the observation group was given 0.1 mg/kg dezocine by intravenous drip 15 minutes before the end of the surgery. The spontaneous breathing recovery time, waking up time, extubation time, visual analogue scale, agitation score and adverse reactions occurred after extubation were compared between the two groups.Results　The spontaneous breathing recovery time, the average wake-up time and the average decannulation time in the observation group were significantly less than those in the control group(P<0.05).Conclusion　Dezocine is effective to prevent stir and pain in the acute calculus incarcerated cholecystitis patients treated by laparoscopic cholecystectomy during the awakening period.]]> 2017/12/4 8:38:51 FENG Ji-ze, CAO Bao-feng 332true ［Abstract］　Objective　To analyse the clinical efficacy and safety of flunarizine hydrochloride in the treatment of cerebral arteriosclerosis.Methods　100 patients with cerebral arteriosclerosis were randomly divided into the observation group and the control group, with 50 cases in each group. The two groups were given the control of blood glucose, blood pressure, adjusting blood lipid, and anti- platelet by Xuesaitong treatment. Besides the above treatments, the observation group was given flunarizine hydrochloride 10 mg, one time per 24 hours. After two weeks of the treatment, the clinical efficacy and safety were compared between the two groups.Results　The efficacy of the observation group was markedly effective in 27 cases, effective in 16 cases and invalid in 7 cases; the efficacy counterparts of the control group were 13, 19, 18 respectively. The total efficacy of the observation group was better than that of the control group(P<0.01). Whole blood viscosity, plasma viscosity and whole blood low shear viscosity in the two groups were lower than those before treatment(P<0.01), the above indicators of the observation group decreased more significantly than those of the control group(P<0.01). No serious adverse reactions occurred in the two groups.Conclusion　Flunarizine hydrochloride is safe and effective in the treatment of cerebral arteriosclerosis.]]> 2017/12/4 8:38:51 LI Gui-ying 331true ［Abstract］　Objective　To investigate the clinical effect of short-segment pedicle screw fixation for the treatment of thoracolumbar burst fracture and to provide a reference for clinical treatment.Methods　68 patients with thoracolumbar fracture were selected from January 2009 to December 2013 and randomly divided into the observation group and the control group accordding to the digital table. The control group was treated with short-segment pedicle screw fixation and the observation group was treated with the same treatment combined with the additional fixation. The sagittal Cobb angle, the leading edge of vertebral height ratio, VAS pain scores, the American Spinal injury Association(ASIA) neurological rating were recorded in all patients before and after the treatment and compared between the two groups after a follow-up of one year.Results　After one year of the treatment, Cobb angle of the observation group was significantly lower than that of the control group［(6.19±1.87)° vs (7.86±2.76)°,t=6.247, P=0.008］; Vertebral leading edge height ratio of the observation group(94.22±10.37)% was significantly higher than that of the control group (86.55±9.93)%(t=4.247,P=0.018); VAS score of the observation group(0.97±0.17) was significantly lower than that of the control group（1.69±0.66）(t=3.553, P=0.024); There was no significant difference in ASIA rating between the two groups(Z=1.076, P=0.246).Conclusion　Short-segment pedicle screw fixation in combination with vertebral fixation has a good clinical effect on thoracolumbar burst fractures.]]> 2017/12/4 8:38:51 WANG Li-ming, XUE Jian-xue, WEI Xing 330true ［Abstract］　Objective　To evaluate the clinical effect of lung protective ventilation strategies on acute respiratory distress syndrome(ARDS).Methods　62 patients with acute respiratory distress syndrome were randomly divided into the control group(n=30) and the observation group(n=32). The control group was treated with conventional ventilation strategy, and the observation group was treated with lung protective ventilation strategies.PaO₂, PaCO₂, PaCO₂/FiO₂ and ventilation time, hospitalization days and the rate of ventilator associated lung injury(VALI) were compared between the two groups.Results　PaO₂, PaCO₂ and PaO₂/FiO₂ at 8 h, 24 h and 48 h after ventilation in the observation were signigicantly higher than those in the control group(P<0.05). The ventilation time, hospitalization days and the rate of VALI in the observation group were signigicantly shorter or lower than those in the control group(P<0.05).Conclusion　Using lung protective ventilation strategies for acute respiratory distress syndrome can signigicantly shorten the ventilation time, hospitalization days and reduce the incidence of VALI. It has important clinical significance for ARDS.]]> 2017/12/4 8:38:51 ZHONG Hua-qiang, HUANG Ke-zan 329true ［Abstract］　Objective　To explore the clinical effect of thioctic acid combined with pregabalin on painful diabetic neuropathy.Methods　84 patients with painful diabetic neuropathy were randomly divided into the control group and the observation group, with 42 cases in each group. The control group was treated with thioctic acid and the observation group was treated with thioctic acid combined with pregabalin. All of the courses of the treatment were 4 weeks. The patients′ pain degree, nerve conduction velocity and occurrence of adverse reactions were observed before and after the treatment.Results　The reduction of VAS score in the observation group was obviously better than that in the control group（P<0.01). The nerve conduction velocity was faster in both of the two groups after the treatment than that before the treatment. There was no significant difference between the two groups（P>0.05）. In the observation group, the clinical effect was excellent in 5 cases, good in 35 cases and invalid in 2 cases. In the control group, the clinical effect was excellent in 3 cases, good in 31 cases and invalid in 8 cases. The curative effect of the observation group was better than that of the control group(t=1.88,P<0.05). The occurrence rate of adverse reactions is not significantly different between the two groups（P>0.05）. No serious adverse reactions occurred in the two groups.Conclusion　The thioctic acid combined with pregabalin in the treatment of the painful diabetic neuropathy is safe and effective to relieve pain and improve therapeutic effect.]]> 2017/12/4 8:40:13 GENG Xiang-hua 328true ［Abstract］　Objective　To observe the effects of Shenfu injection on hemodynamics in patients with heart disease by FloTrac/Vigileo System during induction of general anesthesia.Methods　50 patients with coronary heart disease but without heart operation were randomly divided into Shenfu group and control group, with 25 cases in each group. Shenfu group was intravenously injected with Shenfu injection 1 ml/kg before the induction of anesthesia, and the control group was injected with lactated Ringer′s solution 1 ml/kg in the same way as Shenfu group. Anesthesia induction was performed in both of the groups after 5 min of drug injections. The method of anesthesia induction and maintenance was the same as that in the two groups. Mean arterial pressure(MAP), heart rate(HR), heart output(CO), cardiac index(CI), stroke volume(SV) and stroke volume variation(SVV) were monitored and calculated by FloTrac at T0(baseline level), T1(after injecting Shenfu or lactated Ringer′s solution ), T2(1 min before intubation), T3(tracheal intubation), T4(1 min after tracheal intubation) and T5(5 min after trachea intubation).Results　There were no significantly differences between the two groups at T0, T1(P>0.05); MAP, HR, CO, CI and SV of both groups were significantly decreased at T2 compared with those at T0(P<0.05). CO, CI, SV of Shenfu group were significantly higher than those of the control group(P<0.05); SVV of the control group was significantly increased and significantly higher than that of Shenfu group(P<0.05). At T3 and T4, MAP, HR, CO, CI and SV of both groups were increased, with MAP and HR of the control group being increased more than those of Shenfu group(P<0.05); At T5, MAP, HR, CO, CI and SV of Shenfu group turned to the levels at T0, while those of the control group were lower than the levels at T0(P<0.05).Conclusion　Shenfu injection is effective in attenuating the decrease of CO during the induction of anesthesia,and beneficial to maintaining hemodynamics stability.]]> 2017/12/4 8:40:13 HE Qing-biao, HUANG Wei, MO Li, et al. 327true ［Abstract］　Objective　To investigate the correlation between ACE and CYP2D6 polymorphism and the effect of perindopril.Methods　The genotype was determined by PCR in 158 patients. The differences of left ventricular end-diastolic diameters(LVDD), left ventricular ejection fractions(LVEF) and AngⅡlevel before and after perindopril treatment were detected.Results　The patients with DD/CC, DD/CT and DD/TT phenotype had a great decrease in LVDD and AngⅡ after perindopril treatment.Conclusion　ACE polymorphisms correlates to the effect of perindopril treatment. CYPD2D6 polymorphism does not correlate to the perindopril treatment.]]> 2017/12/4 8:40:13 PENG Jun,HUANG Zi-ming,GUO Guan-hua 326true ［Abstract］　Objective　To explore the changes of serum immune levels and their clinical significances in children with severe hand-foot-and-mouth disease(HFMD).Methods　85 cases with HFMD were selected, among whom 45 cases had severe HFMD and 40 cases had ordinary HFMD. Other 30 cases of healthy children were selected as the control group. Serum immunoglobulin levels and serum cytokine levels of the three groups were detected. The changes and clinical significances of serum immune levels in children with severe HFMD were analyzed.Results　IgM, IgG and IgA levels in both the severe group and the ordinary group were lower than those in the control group（P<0.01）. IgM and IgA levels in the severe group were lower than those in the ordinary group（P<0.01）. IL-1β, TNF-α, IL-6, IL-10 levels in the severe group were higher than those in the ordinary group（ P<0.01）, and all these indicators in both of the two groups were higher than those in the control group（P<0.01）.Conclusion　Children with severe HFMD serum cytokines are significantly increased, indicating that the virus in the body cause a strong inflammatory response and the inflammatory reaction; and that the decrease of immunoglobulin levels shows immune function disorders.]]> 2017/12/4 16:23:24 LIN You-qing 325true ［Abstract］　Objective　To explore the effect of onglyza combined with metformin on the pancreatic β cell function of the senile patients with type 2 diabetes mellitus.Methods　92 senile patients with type 2 diabetes mellitus were randomly divided into the observation group and the control group, with 46 cases in each group. The patients in the control group were treated with metformin combined with placebo and the patients in the observation group were treated with metformin combined with onglyza. FPG, 2hPG, HbA1c, BMI and serum C-peptide levels of the patients were compared between the two groups before and 12 weeks after the treatment. The adverse reactions during the therapy were compared between the two groups.Results　The FPG, 2hPG, HbA1c, BMI, fasting serum C-peptide and postprandial 2 h serum C-peptide level of the patients in the observation group were improved better than those of the patients in the control group（P<0.01). The fasting serum C-peptide and postprandial 2 h serum C-peptide level of the patients in the observation group were significant different before and after the treatment（P<0.01）, and there was no significant difference in the adverse reactions between the two groups during the therapy(P>0.05).Conclusion　Onglyza combined with metformin on the treatment for the senile patients with type 2 diabetes mellitus can lower the fasting and postprandial blood glucose and improve their pancreatic β cell function, control weight and lower hypoglycemia occurrence risk.]]> 2017/12/4 16:23:24 ZHAO Shi-ye 324true ［Abstract］　Objective　To observe the clinical effect and safety of amlodipine and atorvastatin calcium tablets on the patients with hypertension and coronary heart disease.Methods　100 patients with hypertension and coronary heart disease were randomly selected in our hospital from July 2012 to July 2014 and randomly divided into the control group and the observation group, with 50 cases in each group. The control group received nifedipine treatment and the observation group was given amlodipine and atorvastatin calcium tablets. The incidence of blood pressure, blood lipid, clinical curative effect and adverse reaction were compared between the two groups.Results　In the 50 cases of the observation group, 34 cases had markedly effective result, 13 cases had effective results and 3 cases had no effects. In the control group, 13 cases had markedly effective results, 22 cases had effctive results and 15 cases were invalid. Tsystolic blood pressure, diastolic blood pressure, TG and LDL-C were significantly lower in the observation group than those in the control group after the treatment(P<0.05). And HDL-C was higher in the observation group than that in the control group(P<0.05); The overall incidence of adverse reactions in the observation group was significantly lower than that in the control group(4.0% vs 26.0%)(P<0.05).Conclusion　Amlodipine and atorvastatin calcium tablets is a safe and effective treatment in controling blood pressure and improving the blood lipid level on patients with hypertensive and coronary heart disease.]]> 2017/12/4 16:23:24 CHEN Wei, CHEN Ci 323true ［Abstract］　Objective　To evaluate the efficacy of postoperative patient controlled intravenous analgesia(PCIA) with tramadol combined with different doses of sufentanil after gastrointestinal surgery.Methods　According to admission date, 60 patients undergoing gastrointestinal surgery were randomly divided into three groups with 20 patients in each group. Group A received tramadol 300 mg and sufentanil 50 μg. Group B received sufentanil 100 μg and tramadol 300 mg. Group C received tramadol 300 mg and sufentanil 150 μg. Analgesia drugs in each group were added droperidol 2.5 mg and diluted with normal saline to 100 ml. Patient controlled analgesia(PCA) pumps were connected before the end of operations. The mode of analgesia: the load dose was 2 ml, the maintenance dose was 1.2 ml/h, PCA was 2 ml and the locking time was 20 min. The whole observing course was 24 h. Visual analogue scale(VAS）, Ramsay sedation score and side effects were recorded at 2～4 h,8～10 h，12～20 h and 22～24 h respectively after the operation.Results　The VAS scores in group B and group C at each stage after the operation were lower than that in group A(P=0.000). The VAS score in group C at each stage was lower than that in group B after the operation(P=0.000). There was no significant difference in Ramsay sedation score at each stage after the operation among the three groups.Conclusion　Tramadol 300 mg combined with sufentanil 150 μg is effective and safe for postoperative PCIA in patients undergoing gastrointestinal surgery.]]> 2017/12/4 16:23:24 HUANG Jun-shu 322true ［Abstract］　Objective　To investigate the relationship between hypoxia and induced arrhythmias.Methods　207 patients were collected as research objects for the retrospective study. According to the 24 h ECG monitoring, the patients with arrhythmia were taken as the observation group(n=55). Other patients without arrhythmia were collected as the control group(n=152). Pulmonary function, blood gas, degree and time of hypoxia and the correlation between the onset time and the frequency of hypoxia-induced arrhythmia were analyzed and compared between the two groups.Results　There were no significant differences between the two groups in age, gender, BMI, smoking rate, pH, systolic pressure, diastolic pressure and basic heart disease constituent ratio(P>0.05). There was no significant difference between the two groups in cardiac functional grading distribution(P>0.05). FEV1% of the observation group(78.4±3.2) was significantly lower than that of the control group(90.6±1.8), SpO₂ value of the observation group(0.84±0.06) was significantly lower than that of the control group(0.97±0.04 )(P<0.01). There were no significant differences in SpO₂ and arrhythmia occurrence frequency among the three subgroups of the observation group who suffered from coronary heart disease, AMI and hypertension heart disease（P>0.05）. There were significant differences in discrepancy between hypoxia and arrhythmia occurrence time among the different gruops（P<0.05）. There were significant negative correlations between arrhythmia occurrence frequency and SpO₂ value, FEV1% value in the observation group(r=-0.376, P<0.05; r=-0.331, P<0.05). Hypoxia had no significant correlation to the occurrent time of arrhythmia.Conclusion　The patients with arrhythmia combined with basic heart diseases have lower SpO₂, FEV1% value than the patients without arrhythmia have. There is a negative correlation between the frequency of arrhythrmia and SpO₂ value, FEV1% value.]]> 2017/12/4 16:23:24 GAO Yan-hong 321true ［Abstract］　Objective　To investigate the clinical therapy of high volume hemofiltration(HVHF) combined with plasma exchange(PE) in patients with rhabdomyolysis(RM) combined with multiple organ dysfunction syndrome(MODS).Methods　Twenty patients with RM combined with MODS were enrolled from January 2010 to September 2014 in our hospital and were randomly divided into two groups: HVHF group(n=10) and HVHF combined with PE group(n=10). The changes of the vital signs, APACHE Ⅱ score, serum creatinine, blood urea nitrogen,lactate dehydrogenase, creatine kinase, alanine aminotransferase, aspartate aminotransferase, myoglobin, tumor necrosis factor-α, interleukin-1 and interleukin-6 levels were compared between the two groups after the treatments for 5 days.Results　The vital signs were more stable in both of the two groups after 5 days of the treatment compared with pretreatment. APACHE Ⅱ score, serum creatinine, blood urea nitrogen, lactate dehydrogenase, creatine kinase, alanine aminotransferase, aspartate aminotransferase, myoglobin, tumor necrosis factor-α, interleukin-1 and interleukin-6 levels were significantly declined in both of the two groups after the treatments for 5 days （P<0.05）. Myoglobin was significantly reduced in HVHF combined with PE group than that in HVHF group（P<0.01）. The levels of serum creatinine, blood urea nitrogen, lactate dehydrogenase, creatine kinase, alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor-α, interleukin-1 and interleukin-6 were not significantly different between the two groups（P>0.05）.Conclusion　The inflammatory factors and myoglobin are effectively eliminated in patients with RM combined with MODS by both HVHF and PE, which improve the clinical symtoms and prognosis of the patients. PE is obviously better than hemofiltration(HF) to remove myoglobin filter coefficients. HVHF combined with PE is the preferent method for treating RM combined with MODS.]]> 2017/12/6 8:06:37 WU Ji, ZHAO Jing-yu, WANG Nai-ping 320true ［Abstract］　Objective　To reduce nosocomial infection of meticillin-resistant staphylococcus aureus(MRSA) in pediatric intensive care unit(PICU) by real-time fluorescence PCR.Methods　From July 2011 to June 2012, 856 specimens in PICU were detected for MRSA by using real-time fluorescence PCR and isolation-culture-K-B paper disk diffusion method. The nosocomial infection rate during the period from July 2009 to June 2010 was compared with that from July 2011 to June 2012.Results　Thirty-three strains of staphylococcus aureus were identified by culture and real-time fluorescence PCR. Of the 33 clinical isolated staphylococcus aureus, 12 isolates were defined as MRSA by K-B paper disk diffusion method and 14 isolates were defined as MRSA by real-time fluorescence PCR. The two isolates which were defined as positive by real-time fluorescence PCR and negative by K-B paper disk diffusion method were proved to be MRSA positive by sequencing method. Nosocomial infection rates reduced from 36.4%, 37.5% to 16.7%.Conclusion　The real-time fluorescence PCR can identify MRSA more rapidly and accurately and help reduce the rate of nosocomial infection of MRSA in PICU.]]> 2017/12/6 8:06:37 DAI Ying, WANG Qi-wei, HE Shu, et al. 319true ［Abstract］　Objective　To observe the curative effect of salmeterol fluticasone on patients with bronchiectasis and limited airflow.Methods　51 patients with bronchiectasis and limited airflow were randomly divided into treatment group(n=26) and control group(n=25). The two groups were treated with conventional treatment and the treatment group inhaled additional long-term salmeterol fluticasone regularly. Their clinical symptoms, pulmonary functions and sputum neutrophil percentages were observed and measured before and 4 months after the treatment.Results　The clinical symptoms, pulmonary functions and sputum neutrophil percentages had no significant differences between the two groups before the treatment(P>0.05). The clinical symptoms and the pulmonary function were improved significantly in the treatment group after the treatment, and the sputum neutrophil percentage was decreased obviously while there was no obvious change in the control group.Conclusion　Salmeterol fluticasone can improve the clinical symptoms and lung function, reduce the sputum neutrophil percentage in patients with bronchiectasis and limited airflow.]]> 2017/12/6 8:06:37 YUAN Yan-qun, LIU Zhi-rong, YAN Wen-jian 318true ［Abstract］　Objective　To analyze the factors affecting the prognosis in patients with delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods　Fifty-two DEACMP cases were collected from the people′s hospital of Wuming county, the people′s hospital of Guangxi Zhuang Autonomous region and the Jiangbin hospital of Guangxi Zhuang Autonomous region from 2008 to 2014 and were retrospectively studied. According to the results of patients′ daily life ability scale(ADL) scores 3 months after the illness, the patients were divided into non-improvement group(n=25) and improvement group(n=27) on the basis of their recovery progress. The factors affecting the prognosis of DEACMP patients including gender, age, primary diseases, exposure time within the CO, unconsciousness duration, pseudo-recovery period Hyperbaric oxygen(HBO) treatment in acute phase, brain magnatic resonance imaging(MRI) scan, daily life ability scale(ADL) score on admission, and use of Edaravone were compared between the two groups.Results　Age, exposure time within the CO, pseudo-recovery period, HBO treatment in acute stag, complications, abnormal in early brain MRI scan and the higest ADL scores were related to the prognosis of DEACMP patients(P<0.05). Other factors such as gender, primary diseases, unconsciousness duration, brain CT scan, edaravone had no significantly differences(P>0.05).Conclusion　Aging, complications, long time exposure to CO, shorter pseudo-recovery period, HBO treatment in acute stag, abnormal in early brain MRI scan and lower ADL scores indicate poor prognosis in DEACMP patients. More attentions should be paid to the treatment of patients who have these disorders.]]> 2017/12/6 8:06:37 QIN Hui-yue, PAN Xiao-rong, LIANG Rui-feng 317true ［Abstract］　Objective　To observe the clinical effects of the treatment of Thymosin alpha1 on drug resistant pulmonary tuberculosis, and its effects on the patients′ immune function(Th17/Treg).Methods　Sixty-four patients with drug-resistant pulmonary tuberculosis were randomly divided into the observation group and the treatment group（32 cases in each group）. The two groups were treated with western medicine of anti-tuberculosis drug for 18 months as a treatment course. Intramuscular injection of Thymosin alpha1 was added to the treatment group 1.6 mg per time, 2 times a week, consecutively for 3 months. 30 healthy people were taken as the control group. The improvement of tuberculosis lesions, sputum negative conversion rate, peripheral blood T lymphocyte expression and the efficiency and drug adverse reactions were compared between the two groups before and after the treatment.Results　(1)The total efficiency of the observation group and the treatment group were 56.7%and 83.3%(P<0.05). (2)The improvement of tuberculosis lesions and sputum negative rate of the treatment group were higher than those of the observation group after 3 and 6 months of the treatment. (3)Th17, Treg and Th17/Treg in the peripheral blood of the two groups were decreased significantly compared with the control group(P<0.01). Th17, Treg and Th17/Treg in the peripheral blood of the treatment group were increased significantly after 3 and 6 the months of the treatment compared with those before the treatment(P<0.01). There was significant difference between the two groups(P<0.05). (4)The incidences of adverse reaction of the observation group and the treatment group were 26.6% and 20%(P>0.05).Conclusion　Thymosin alpha1 can increase the patients′ immune function and improve the X-ray and clinical efficacy in treatment of drug resistant tuberculosis.]]> 2017/12/6 8:06:37 TAN Jian-ming, JI Qiu-ping, LI Mao-qing, et al. 316true ［Abstract］　Objective　To investigate the clinical outcomes of microvascular decompression(MVD) for the treatment of idiopathic trigeminal neuralgia.Methods　The clinical data, including intra-operative findings, treatment outcomes and complications of 88 idiopathic trigeminal neuralgia patients treated with MVD were retrospectively analyzed.Results　Among the 88 cases undergoing MVD, vascular compression was observed in 84 and arachnoid adhesion without vascular compression in 4. After the operation, pain was disappeared in 80, relieved in 7, and not relieved in 1. No recurrence was found after a follow-up of 6 to 60 months. The postoperative complications included 8 cases of nausea, vomiting and dizziness, 8 facial numbness, 3 facial paralysis, 2 hearing loss, 1 poor incision healing, 5 subcutaneous hydrops and 1 cerebrospinal fluid otorrhea. No death or disability occurred.Conclusion　MVD is a safe and effective surgical method for the treatment of idiopathic trigeminal neuralgia.]]> 2017/12/6 16:26:21 LIU Ruo-ping, XIAO Quan, PANG Gang, et al. 315true ［Abstract］　Objective　To study the efficacy and safety of large dose LMWH with urokinase sequential therapy for intracranial venous sinus thrombosis.Methods　Ninety-seven patients with intracranial venous sinus thrombosis were selected, according to different anticoagulation therapies and divided into 3 groups, experimental A group(33 cases), using large dose of LMWH(5 000 U, twice/d) with urokinase(100 000 U, once/d) sequential therapy, experimental B group(32 cases), using low dose of LMWH(5 000 U, once/d) with urokinase(100 000 U, once/d) sequential therapy, control group(32 cases), using warfarin 2.5 mg, qd, P.O. Therapeutic effects and adverse reactions in all groups were compared.Results　The efficient rate and sinus revascularization rate of experimental A group were the highest. Followed were respectively experimental B group and the control group(P<0.05). Before the treatment, there was no significant difference in the average intracranial pressure among the three groups(P>0.05). After 3 or 6 months′ treatment, the average intracranial pressure of experimental A or B group was obviously lower than that of the control group and pre-therapy(P<0.05). There was significant difference between the experimental A and B group(P<0.05). The highest recovery rate and the lowest mortality rate were in experimental A group. Followed was experimental B group. The lowest recovery rate and the highest mortality rate were in the control group(P<0.05). There was no significant difference in the extracranial blood rate among the three groups(P>0.05). After symptomatic treatment all were relieved.Conclusion　A large dose of LMWH with urokinase sequential therapy is efficient for intracranial venous sinus thrombosis. It can enhance thrombosis absorption, increase venous sinus revascularization, reduce intracranial pressure and improve prognosis.]]> 2017/12/6 16:26:21 SHI Yu-liang, YANG Yu-xian, YE Hong-tao, et al. 314true ［Abstract］　Objective　To analyze the effect of periodontal treatment on glycosylated hemoglobin and fasting blood glucose in type 2 diabetes(T2DM) patients with chronic periodontitis(CP).Methods　Sixty T2DM patients with CP were randomly divided into intervention group(n=30) and control group(n=30). The subjects in the intervention group received periodontal therapy while the control group only received oral health education. Periodontal clinical health parameters and glycemic control parameters were recorded at baseline and after periodontal treatment.Results　Compared with the baseline, PD, PLI, GBI and HbA1c in the intervention group were significantly reduced after periodontal treatment(P<0.05) while FBG did not show any apparent reduction(P>0.05).Conclusion　Periodontal treatment can effectively reduce the CP, PD, PLI, GBI and HbA1c in T2DM patients with CP.However,no significant effect was found on FBG.]]> 2017/12/6 16:26:21 XU Jie 313true ［Abstract］　Objective　To investigate the effect of large dose of ulinastatin on respiratory mechanics and oxidative stress in patients with acute respiratory distress syndrome(ARDS).Methods　54 patients with ARDS in our hospital from Jan. 2011 to Aug. 2013 were randomly divided into observation group and control group, with 27 cases in each group. The control group was treated with conventional therapy. The observation group was treated with large dose of ulinastatin on basis of conventional treatment, the changes of respiratory mechanics indexes and oxidative stress parameters before and after treatment between the two groups were compared.Results　The positive end expiratory pressure(PEEP) in the control group was significantly lower than that before treatment, the static lung compliance was significantly higher than that before treatment(P<0.05); the inspiratory resistance and PEEP in the observation group were significantly lower than those before treatment(P<0.05), the static lung compliance was significantly higher than that before treatment(P<0.05). After treatment, the inspiratory resistance and PEEP in the observation group were significantly lower than those in the control group(P<0.05), the static lung compliance was significantly higher than that in the control group(P<0.05). Malondialdehyde in the control group was significantly lower than that before treatment(P<0.05), superoxide dismutase was significantly higher than that before treatment(P<0.05); malondialdehyde in the observation group was significantly lower than that before treatment(P<0.05), superoxide dismutase, glutathione and total oxidative capacity were significantly higher than those before treatment (P<0.05). After treatment, malondialdehyde in the observation group was significantly lower than that in the control group, superoxide dismutase, glutathione and total oxidative capacity were significantly higher than those in the control group(all P<0.05).Conclusion　Large dose of ulinastatin intravenous injection can effectively improve respiratory mechanics and oxidative stress of patients with ARDS, reduce lung injury, improve pulmonary ventilation function and play a positive role in improving prognosis of patients with ARDS.]]> 2017/12/6 16:26:21 LI Jing, YANG Yu-ling, YUAN Dong-dong 312true ［Abstract］　Objective　To investigate the clinical curative effect of treating thoracolumbar fracture and dislocation with pedicle screw rod internal fixation.Methods　Fifty patients with thoracolumbar fracture and dislocation were collected, who were treated with pedicle screw rod fixation. The condition of spinal cord injury recovery, the percentage of anterior and posterior edge height of disease vertebral, the occurrence of complications and the condition of Cobb angle recovery were observed before internal fixation, at immediate after internal fixation and at a followed-up of 12 months.Results　Fifty patients were followed up for 12 months. The percentage of anterior and posterior edge height of disease vertebrae at immediate after fixation, at a followed-up of 12 months were increased evidently than those before fixation(P<0.01), the Cobb angle was decreased obviously than before fixation(P<0.01). Between the time points at immediate after fixation and at a followed-up of 12 months, the percentage of anterior or posterior edge height of disease vertebra and Cobb angle had no significant differences(P>0.05). Before internal fixation, the spinal cord injury mainly distributed at B level, C level, but at immediate after internal fixation and at a followed-up of 12 months after internal fixation, they distributed mainly in D level and E level, anterior spinal cord injury distribution at instant after internal fixation and at a followed-up of 12 months after internal fixation had significant difference from that before internal fixation(P<0.01), and between the time point at immediate after internal fixation and the time point at 12 months followed-up after internal fixation, the distribution of spinal cord injury had no significant differences(P>0.05).Conclusion　For patients with thoracolumbar fracture and dislocation, pedicle screw rod internal fixation can effectively restore vertebral height and promote injured spinal nerve function.]]> 2017/12/8 8:10:56 ZHANG Qin-xin 311true ［Abstract］　Objective　To investigate the effect of ofloxacin combined with piperacillin sodium and tazobactam sodium in the treatment of severe pneumonia(SP).Methods　110 patients with SP were selected and randomly divided into two groups. The control group was treated with piperacillin sodium and tazobactam sodium. The observation group was treated with piperacillin sodium and tazobactam sodium combined with ofloxacin.The clinical efficacy of the two groups were compared.Results　The clinical symptoms, signs and laboratory test, mechanical ventilation, sputum, blood test and chest X-ray in the observation group were significantly less than those in the control group(P<0.05). After treatment, the WBC count in the observation group was significantly lower than that in control group(P<0.01). Both PaO₂ and PaCO₂ were higher in the observation group than those in the control group(P<0.01). The efficacy of the observation group was better than that of the control group(P<0.01). After treatment, ALT, AST, BUN, Cr had no significant difference between the two groups after treatment compared with before treatment(P>0.05).Conclusion　Combination of ofloxacin and piperacillin sodium and tazobactam sodium in the treatment of SP has a satisfactory effect, and no obvious adverse reaction is observed on liver and kidney functions.]]> 2017/12/8 8:10:56 LAO Ke-liu 310true ［Abstract］　Objective　To evaluate the diagnostic value of using 16-slice spiral CT scan and Multi-planar reconstruction(MPR) on solitary pulmonary nodules(SPN).Methods　21 patients with small peripheral lung cancer and 29 patients with benign SPN were confirmed by pathology and analyzed retrospectively using CT imaging data. All patients underwent 16-slice spiral CT volume scanning and MPR.Results　MPR images could display more special features of lesions than conventional transverse scanning, such as pleural indentation, vascular bundle, small calcification, spicule sign, vacuole sign, spinous protuberance etc.Conclusion　16-slice spiral CT scan and MPR shows more signs of SPN than conventional transverse scanning. It is valuable to use this technique to scan SPN and distinguish between benign and malignant lung tumors.]]> 2017/12/8 8:10:56 LI Quan-ling 309true ［Abstract］　Objective　To explore the value of contrast enhanced ultrasound(CEUS) breast lesions in differential diagnosis.Methods　Making the results of the pathology test as standard, an CEUS process analysis of breast lesions was performed in 261 patients who were diagnosed as breast tumor by 2-dimensional CEUS before operation and the parameter value of Time-Intensity Curve was gotten by SonoLiver software, and the results obtained were compared with the result of the pathology test after operation(benign 169 cases/186 lesions, malignant 92 cases/121 lesions).Results　The CEUS of malignant tumor showed that lesions had an early rapid, non-uniform, high enhancement and peripheral radial enhancement. The benign tumor showed that lesions had an early slow, uniform, low or no enhancement, and no peripheral radial enhancement. Significant decrease of length width ratio of breast lesions after radiography maybe suggest a malignant tumor. There was a significant difference in the ROI mode intensity between benign and malignant lesions（P<0.01）. Comparison of the results between radiography and pathology shaved, in 181 benign lesions, 166 were correct on CEUS, 20 were misdiagnosed as malignant, and in 121 malignant lesions, 103 were correct on CEUS, 18 were misdiagnosed as benign. For diagnosis of malignant tumor, CEUS showed the sensitivity was 85.1%, specificity was 89.2% and accuracy was 87.6%.Conclusion　CEUS can observe dynamically the situation of microvascular blood perfusion in breast lesions, and application of SonoLiver software can analyze lesions quantitatively and improve the levels of differential diagnosis of benign and malignant breast tumors.]]> 2017/12/8 8:10:56 LV Zhi-hong, HAN E-hui, HONG Wei, et al. 308true ［Abstract］　Objective　To study the consistence of low-dose CT colonography（CTC） and sigmoidoscopy in the diagnosis, site and classification of colon carcinoma（CRC）.Methods　A total of 65 patients of CRC were confirmed by pathology. All the patients were examined by endoscopy and low doses CTC. The location, types of tumour were observed by endoscopy and CTC, and Kappa consistence test was applied with the pathologic findings as golden standard, and calculated CT dose index(CTDIw) in prone was recorded.Results　Sixty-one patients were diagnosed as having CRC by endoscopy and 4 were negative. In 61 positive patients, 8 tumors located in the rectum, 25 in the colon sigmoideum, 13 in the descending colon, 11 in the colon transversum, 8 in the ascending colon, and Borrmann showed, Ⅰ in 38, Ⅱ in 14, Ⅲ in 7, Ⅳ in 6. CTC diagnosed 60 cases of CRC and 5 cases with negative results. In 61 positive patients, 6 tumors located in the rectum, 23 in the colon sigmoideum, 15 in the descending colon, 10 in the colon transversum, 6 in the ascending colon, and Borrmann showed, Ⅰ in 36, Ⅱ in 16, Ⅲ in 7, Ⅳ in 6. There was high consistency between CTC and sigmoidoscopy in the diagnosis of CRC（Kappa=0.881, P<0.01）, with the coincidence of CTC was 98.5%. There was high consistency between CTC and sigmoidoscopy in the classification of CRC（Kappa values were 0.897 and 0.949, P<0.01）.Conclusion　Reduction of the effective dose to 1.68 mGy significantly affects images quality on CTC, there is high consistency between CTC and sigmoidoscopy in the diagnosis, site and classification of CRC.]]> 2017/12/8 8:10:56 LI Jia-yan, HE Xin, GAO Chun-ping, et al. 307true ［Abstract］　Objective　To study the curative and side effects of small dose of iron supplements on the intermittent treatment for children with iron deficiency anemia(IDA).Methods　133 children with IDA were divided into two groups, respectively given A group(small doses of intermittent iron supplements) and B group(regular daily dose iron supplement as control group). After two months′ treatment, serum ferritin(SF) and hemoglobin(Hb) were detected and adverse reactions were observed in the two groups.Results　SF and Hb were same after treatment. They were significantly elevated in both groups(P<0.01). There was no significantly difference between two groups after treatment(P>0.05). The adverse reaction rate of B group was obviously higher than that of A group(P<0.01).Conclusion　Small dose of iron supplements of intermittent treatment for the children with IDA is effective and has lower side effects.]]> 2017/12/8 8:10:56 PANG Qing-hua, WU Yong 306true ［Abstract］　Objective　To explore the clinical significances of IL-18 and TNF-α in the development of osteoarthritis.Methods　Seventy-one patients with knee osteoarthritis were selected as OA group and 30 healthy adults as control group. Radioimmunoassay was used to check the contents of IL-18 and TNF-α in articular synovial fluid, and the results were analyzed statistically.Results　The contents of IL-18 and TNF-α in articular synovial fluid in OA group were higher than those in control group(P<0.01).Conclusion　IL-18 and TNF-α are involved in the pathological process of destruction of articular cartilage and synovial inflammation.]]> 2017/12/12 9:29:09 WEI Hai-tao, DONG Le-le, FAN Jian-jun, et al. 305true ［Abstract］　Objective　To evaluate the efficacy of reconstruction of stenose hilar bile duct with pedicled ligamentum teres hepatis in the treatment of intrahepatic bile duct stones.Methods　Fifty patients with intrahepatic bile duct stones were randomly divided into two groups. The control group(n=25) received hepatectomy, and the observation group(n=25) received bile duct reconstruction with pedicled ligamentum teres. The liver function, per-operative bleeding, time of operation, the incidence of postoperative bile leakage and residual stones in the two groups were calculated and analyzed.Results　Peri-operative bleeding and time of operation in the observation group were less than those in the control group(P<0.05). The degree and time of postoperative hepatic function recovery in the observation group were better than those in the control group(P<0.05). There was no significant difference in the incidence of postoperative bile leakage and residual stones between the two groups(P>0.05).Conclusion　For patients with slenose hilar bile duct caused by intrahepatic bile duct stones, bile duct reconstruction with the ligamentum teres hepatis is effective and safe, with less bleeding and shorter time of operation.]]> 2017/12/12 9:29:09 JIANG Han-cheng, JIANG Shui-ming, AN Meng-zeng, et al. 304true ［Abstract］　Objective　To evaluate hepatectomy for liver metastasis in patients with gastric cancer.Methods　Thirty-two patients with gastric cancer had undergone hepatectomy for hepatic metastatic tumor from January 2008 to January 2013 in our hospital. Of them, 16 patients underwent radical gastrectomy and synchronous hepatectomy for liver metastasis, the other 16 patients underwent radical resection of gastric cancer and liver resection heterochronously. The relationship between prognosis and clinicopathology was analyzed.Results　The overall survival rates at 1 year, 3 years and 5 years were 84%, 50% and 37%, respectively. The median survival time was 32 months. The single factor analysis showed that gastric cancer invasion depth, intravascular tumor thrombi, lymphatic metastasis and intraoperative blood transfusion were related to poor prognosis while the multiple factors analysis showed that gastric serosal invasion, tumor thrombus and liver metastasis tumor ≥5 cm were related to poor prognosis.Conclusion　Gastric cancer patients with liver metastasis who underwent hepatic resection can achieve good prognosis if hepatic metastatic tumor <5 cm or the primary gastric cancer does not invade the serosa and without tumor thrombus.]]> 2017/12/12 9:29:09 WU Zhi-heng 303true ［Abstract］　Objective　To observe the clinical efficacy of verruca vulgaris treated by intralesional injection of polyinosinic acid-polycytidylic acid(Poly IC).Methods　The patients were randomly divided into two groups, the treatment group(n=30) was treated by intralesional injection of Poly IC, the control group(n=30) by liquid nitrogen cryotherapy.Results　The effective rate of the treatment group was 86.67%, that of the control group was 53.33%, the difference between the two groups was significant(P<0.01); The relapse rate in treatment group was 3.85%, that of the control group was 31.25%, the difference the between two groups was statistically significant(P<0.05).Conclusion　Intralesional injection of Poly IC in the treatment of verruca vulgaris has significantly curative effect.]]> 2017/12/12 9:29:09 SUN Shi-ming, LI Juan 302true ［Abstract］　Objective　To investigate the effects of early administration of large dose rosuvastatin（40 mg） on coronary microvascular function and short-term outcome in patients treated with primary percutaneous coronary intervention for acute myocardial infarction.Methods　94 consequent AMI patients treated with primary PCI were divided into control group（n=44） and observation group（n=50）. The infarct-related artery flow of epicardium was classified in compliance with the TIMI criteria. Myocardial and microvascular perfusion was assessed using the TMPG. The incidence of the MACE and the cytotoxicity and hepatotoxicity of rosuvastatin were respectively recorded in 30 days′ follow-up.Results　TMPG in both observation group and control group improved immediately after PCI（P<0.05）. However, the post-PCI TMPG of observation group improved better than that of the control group（P<0.05）. The 30-day composite MACE rate was lower in the observation group than that in the control group（12.0% vs 34.1%，P<0.05）. The incidence of TMPG 3 patients was lower in observation group than that in the control group（11.1% vs 42.9%，P<0.05）. No cytotoxicity and hepatotoxicity happened in the two groups.Conclusion　Early administration of large dose rosuvastatin（40 mg） can improve coronary microvascular function and short-term outcome in patients treated with primary percutaneous coronary intervention for acute myocardial infarction, and is safe.]]> 2017/12/12 9:29:09 FAN Fu-rong, HOU Yan 301true ［Abstract］　Objective　To explore the clinical features in elderly hypertensives(HT) with acute myocardial infarction(AMI).Methods　A comparative analysis was performed on the clinical data in 82 elderly HT with AMI and 64 elderly non-hypertensives(NHT) with AMI.Results　There were statistically significant differences in the pulse pressure, painless myocardial infarction, complications,hospital mortality between two groups(P<0.05).Conclusion　Elderly HT with AMI has the following characteristics:large pulse pressure, high incidence of painless myocardial infarction, high incidence of complications such as left ventricular hypertrophy, heart failure, arrhythmia, and high mortality, poor prognosis in the near future.]]> 2017/12/12 9:30:01 WANG Min-chen 300true ［Abstract］　Objective　To investigate the relationship between hsCRP, serum lipid level and left ventricular hypertrophy(LVH) in patients with hypertension.Methods　Eighty-two patients with hypertension and 76 controls were included, hsCRP，FPG, TC, TG，HDL-C and LDL-C were measured. All subjects were taken echocardiography examination, then LVMI was calculated.Results　(1)hsCRP, LVMI and TG in patients with hypertension were significantly higher than those in controls［(5.13±2.36)mg/L vs (4.06±2.21)mg/L，P=0.006;(108.7±9.9)g/m² vs (88.3±10.4)g/m²，P=0.000; (3.0±0.6)mmol/L vs (1.3±0.5)mmol/L，P=0.000］，and HDL-C in patients with hypertension was significantly lower than that in controls［(1.0±0.1)mmol/L vs (1.6±0.1)mmol/L，P=0.004］. (2)In a multiple linear step-wise regression analysis, when taking LVMI as dependent variable and other factors as independent variables, we found that hsCRP, SBP, TG, and DBP were main determinants for LVMI. (3)Patients with hypertension were divided into other two subgroups according to LVMI:hypertension with LVH(group A) and hypertension without LVH(group B).hsCRP of group A was significantly higher than that of group B［(5.9±1.59)mg/L vs (5.0±2.23)mg/L，P=0.017］.Conclusion　Inflammation exists in hypertension patients and becomes worse in hypertension patients with LVH.Inflammation and serum lipid level influence LVH in patients with hypertension.]]> 2017/12/12 9:30:01 GUAN Wei 299true ［Abstract］　Objective　To explore the value of procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP) and white blood cell(WBC) in the diagnosis for pulmonary bacterial infection.Methods　One hundred and fourteen patients with pulmonary infection were chosed in this study and were divided into two groups:positive group(sixty-three patients with bacterial infection),negative group(fifty-one patients with non bacterial infection).The levels of serum PCT, hs-CRP and the periphal WBC were detected and compared in the two groups.Results　The levels of serum PCT,hs-CRP and WBC in bacterial infection group were significantly higher than those in non bacterial infection group.The cut-off point of serum PCT in the diagnosis of pulmonary bacterial infection was 0.5 ng/ml. Based on this,the sensitivity,specificity, accuracy,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio were 0.921,0.882,0.904,0.906,0.900,7.825 and 0.090 respectively. The specificity of combined detection of PCT, hs-CRP and WBC levels in the diagnosis of pulmonary infection was high.Conclusion　The combined detection of PCT， hs-CRP and WBC levels is helpful in the diagnosis and differential diagnosis for pulmonary bacterial infection.]]> 2017/12/12 9:30:01 LIU Hua-xiang,YUE Feng, WU Tao 298true ［Abstract］　Objective　To explore the high-risk factors for postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma during pN0 stage, and to provide rational postoperative adjuvant treatment and enhance long-term survival rate.Methods　Clinical data of 76 patients diagnosed with thoracic esophageal squamous carcinoma(pN0 stage), admitted to Quanzhou Guangqian Hospital, Fujian Province from January 2003 to December 2010 were analyzed retrospectively. Cox proportional-hazards regression model was adopted to analyze the risk factors for recurrence and metastasis within postoperative 3 years.Results　The recurrent metastasis rate was 34.2% within postoperative 3 years. Univariate analysis revealed the tumor location, pT staging and vascular thrombosis were correlated with postoperative recurrence and metastasis(all P<0.05). Multivariate analysis suggested that the middle and upper esophageal cancer, pT3-4a and vascular thrombosis were the independent risk factors for the postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma during pN0 stage.Conclusion　The middle and upper esophageal cancer, pT3-4a and vascular thrombosis act as independent risk factors for the postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma during pN0 stage. Postoperative adjuvant treatment should be delivered actively.]]> 2017/12/12 9:30:01 HUANG Xian-qiang 297true ［Abstract］　Objective　To explore the effect of treating diabetic nephropathy(DN) by calcium dobesilate combined with losartan potassium on proteinuria in patients with DN, and its safety.Methods　Seventy-two patients with DN who were treated were collected from Mar. 2011 to Aug. 2013.According to draw method，they were divided into losartan potassium group and combination group, 36 cases in each group. Losartan potassium group was orally treated with losartan potassium 50 mg/d on basis of conventional treatment.The combination group was orally treated with calcium dobesilate capsules,500 mg/time,3 times a day,on basis of losartan potassium group,the treatment course was two months.The change in serum creatinine(Cr), blood urea nitrogen(BUN), 24 hours′ urinary albuminexcretion rate(UAER) before and after treatment and the occurrence of adverse reactions during treatment were compared between the two groups.Results　The Cr, BUN, 24 hours′ UAER before treatment had no significant difference between the two groups; after treatment,the Cr,BUN had no significant difference from those before treatment in the two groups(P>0.05), the 24 hours′ UAER was significantly lower than that before treatment in the two groups(P<0.01), and the 24 hours′ UAER in combination group were significantly lower than that in losartan potassium group(P<0.01). No obvious adverse reaction was found in the two groups.Conclusion　Treating DN with losartan potassium combined with calcium dobesilate can reduce urinary protein excretion, decrease UAER, protect renal function, delay DN progress. It is worthy of clinical reference.]]> 2017/12/12 9:30:01 JIN Ming-wei 296true ［Abstract］　Objective　To explore the clinical effect of different operation methods for the treatment of colorectal neoplasms.Methods　According to the operation modes, 124 patients with colorectal neoplasms were divided into gasless laparoscopic group(suspension group, 42 cases), carbon dioxide pneumoperitoneum laparoscopic group(pneumoperitoneum group, 42 cases), and open operation(laparotomy group, 40 cases). The effects of the operations were compared.Results　The three groups′ patients obtained successful operation, without dead cases. There were no significant difference in operation time, resection length and number of lymph node resection among three groups(P>0.05), but the operation bleeding and exhaust time in suspension group and pneumoperitoneum group were significantly more shortened than laparotomy group(P<0.05).Conclusion　Gasless laparoscopic operation, carbon dioxide pneumoperitoneum laparoscopic operation and open operation in the treatment of colorectal neoplasms have similar effect, but the first two methods have advantages of less damage, faster postoperative recovery, and are worthy of clinical application.]]> 2017/12/18 8:27:00 ZHAO Chang-sheng 295true ［Abstract］　Objective　To investigate the clinical effects of hemodiafiltration combined with hemoperfusion in the treatment of pruritus in maintenance hemodialysis patients.Methods　Sixty maintenance hemodialysis patients with pruritus were randomly divided into treatment group(n=30) and control group(n=30). The treatment group was treated with hemodiafiltration combined with hemoperfusion, ordinary hemodialysis 2 times a week, hemoperfusion combined with hemodiafiltration once, each 2 hours, a total of 4 hours; the control group received ordinary hemodialysis, 3 times a week, every 4 hours; the observations continued 10 weeks. Serum concentrations of PTH, β2-MG in the two groups were observed before and after treatment; And the degree of pruritus were compared.Results　After treatment, both the serum PTH and β2-MG concentration in treatment group was significantly lower than before treatment; pruritus was relived(P<0.05). No significant differences were found in above indexes in the control group before and after treatment（P>0.05）.Conclusion　Hemodiafiltration combined with hemoperfusion can significantly alleviate hemodialysis patients′ pruritus.]]> 2017/12/18 8:27:00 SUN Zhi-hua,SHAO Ning 294true ［Abstract］　Objective　To observe the clinical efficacy of phentolamine, dobutamine, and xueshuantong in the treatment of acute exacerbation of chrohic pulmonary heart disease.Methods　One hundred and twenty patients with acute exacerbation of chronic pulmonary heart disease were randomly divided into observation group and control group with 60 patients in each group. The control group was treated with conventional therapy, and the observation group was treated with phentolamine, dobutamine combined with xueshuantong on the basis of conventional therapy.The therapeutic efficacy were observed after 10 days of treatment.Results　The curative effect of the observation group showed was excellent in 40 patients, effective in 16 patients, noneffective in 4 patients. The curative effect of the control group showed marked was excellent in 26 patients, effective in 15 patients,no effect in 19 patients,there was a significant difference in the therapeutic efficacy between two groups(P<0.01). After treatment all indexes of cardiac function and hemodynamics and blood gas analysis were improved significantly in two groups(P<0.05),but the observation group was better in improving the above indexes compared with in the control group(P<0.01).Conclusion　On the basis of the conventional therapy, the use of phentolamine, dobutamine combined with xueshuantong in the treatment of patients with acute exacerbation of chronic pulmonary heart disease has better curative effects.]]> 2017/12/18 8:27:00 HUANG Zu-wang 293true ［Abstract］　Objective　To evaluate the clinical significance of plasma ionized calcium(ICa)and total calcium(TCa)measurement in the diagnosis of tumor-associated hypercalcemia.Methods　The heparin lithium anticoagulated plasma were collected and measured with ion selective electrode(ISE) and orthocresolphthalein complexone(OCPC) method for ICa and TCa in 60 patients with malignant tumor(research group) and 50 healthy people(control group). Plasma albumin and pH value were measured to correct TCa(cTCa) and ICa(nICa).Results　The levels of cTCa，ICa and nICa in research group were significantly higher than those in control group ［(2.56±0.20)mmol/L vs (2.31±0.11)mmol/L,(1.15±0.22)mmol/L vs (1.01±0.30)mmol/L and (1.30±0.11)mmol/L vs (1.18±0.02)mmol/L，respectively；(P<0.05)］，but there was no significant difference in TCa between two groups［(2.41±0.02)mmol/L vs (2.43±0.12)mmol/L，(P>0.05)］.In the research group，when taking nICa>1.35 mmol/L or cTCa>2.70 mmol/L as the hypercalcemia critical value，the positive rate of nICa and cTCa were 18.33%(11/60) and 6.67%(4/60)，respectively,the difference was significant(χ²=9.458，P=0.036).Conclusion　Determination of ICa may be more clinical meaningful than TCa for tumor-associated hypercalcemia.]]> 2017/12/18 8:27:00 BI Yan-mei 292true ［Abstract］　Objective　To observe the clinical efficacy of oral ibuprofen sustained-release capsules combined with external application of Chinese medicine in the treatment of knee osteoarthritis.Methods　Forty patients with knee osteoarthritis as the observation group and treated by oral ibuprofen sustained-release capsules combined with external application of Chinese medicine. Forty cases in the control group were treated with oral ibuprofen sustained-release capsules,10 days were used as a course of treatment.Results　In the treatment group, 5 cases were cured, 20 cases were marked effective, 12 cases were effective and 3 cases were ineffective. In control group, 2 cases were cured, 13 cases were marked effective, 16 cases were effective and 9 cases were ineffective. The therapeutic effect of the observation group was better than that of the control group(P<0.05). Compared with the scores before and after treatment, the scores in pain, walking distance, joints function, swelling and activity of daily living all decreased significantly in two groups, but the therapeutic effect of the observation group was better than that of the control group（P<0.05）.Conclusion　Ibuprofen sustained-release capsules combined with external application of Chinese medicine in the treatment of knee osteoarthritis has significant clinical efficacy and safety.It is worthy of clinical application.]]> 2017/12/18 8:27:00 HE Han-wu, WU Long-zhang 291true ［Abstract］　Objective　To compare the effects of C-arm guided lumbar plexus and sciatic nerve blockade and epidural anesthesia on elderly patients with lower limb surgery.Methods　Sixty elderly cases(ASAⅠ～Ⅲ) were divided into the lumbar plexus and sciatic nerve blockade group(group A, n=30) and the epidural anesthesia group(group B, n=30). Patients in group A received C-arm guided lumbar plexus and sciatic nerve blockade, with 30 ml and 20 ml of 0.375% ropivacaine administrated to the lumbar plexus and sciatic nerve respectively; Patients in group B received epidural anesthesia and were administrated with 10～15 ml of 0.375% ropivacaine. Hemodynamic changes, the effects of blockade and adverse reactions were observed in both groups.Methods　The systolic pressure, diastolic pressure and heart rate in group A were more stable than those in group B. The number of patients using ephedrine in group A was much smaller than that in group B（P<0.01）. The sensory block onset time of group A was longer than that of group B（P<0.01）, while the hold time of sensory and motor nerve block onset time of group A was significantly longer than that of group B(P<0.01). Adverse reactions such as nausea, vomit and retention of urine in group B during the preoperative period were much more severe than those in group A(P<0.01).Conclusion　The application of lumbar plexus and sciatic nerve blockade in unilateral lower limb surgery can not only meet the surgical requirements, but also have a small impact on hemodynamics, less complications, longer duration of pain relief and less adverse reactions. Therefore, it is especially suitable for frail elderly patients.]]> 2017/9/12 9:14:26 TIAN Wen-hua, GAO Song, YANG Fan, et al. 290true ［Abstract］　Objective　To investigate the effect and safety of dexmedetomidine combined with propofol on induced abortion under Narcotrend monitoring.Methods　Sixty patients with ASA Ⅰ or Ⅱ, undergoing induced abortion, were randomly divided into dexmedetomidine group(group D) and propofol group(group P), with 30 cases in each group. The monitoring of anesthesia depth was given in the two groups. After anesthesia induced under Narcotrend monitoring, group D was injected with dexmedetomidine 0.4 μg/kg within 10 min by intravenous injection, and then injected with propofol 2 mg/kg. Group P was injected with propofol 2.5 mg/kg alone, if necessary, propofol was added. The treatment started after NI dropped to set the value of D2(NI=37～46), and the medication was added according to whether the NI was in the target range or not. MAP, heart rate(HR) and pulse oxygen saturation(SpO₂) were recorded at the time points of pre-anesthesia(T0), loss of consciousness(T1), the palace cavity suction(T2) and recovery(T3). The time of recovery and orientation recovery, the dosage of propofol, anesthesia effect and adverse reaction were recorded.Methods　There were no significant differences in the anesthetic effect between the two groups(P>0.05). HR, MAP and SpO₂ at T1 were significantly lower than those at T0(P<0.05); MAP and SpO₂ decreased more in group P than those in group D(P<0.05), MAP of group P at T2 was lower than that of group D and at T0(P<0.05). The time of awaken and orientation recovery in group P was longer than that in group D(P<0.05). The dosage of propofol in group P was significantly higher than that in group D(P<0.05). Respiratory depression, dizziness and restlessness occurrence rate in group P were significantly higher than those in group D(P<0.05).Conclusion　Dexmedetomidine combined with propofol in treatment of painless anesthesia can reduce the dose]]> 2017/9/12 9:14:26 HE Qing-biao, HUANG Wei, MO Li, et al. 289true ［Abstract］　Objective　To investigate the effect of large dose of dexamethasone combined with rituximab on CD4⁺CD25⁺ Treg cells in the patients with primary immune thrombocytopenia.Methods　One hundred and forty-six patients with ITP were collected and divided into the control group(n=51), dexamethasone group(n=47) and combination group(n=48). 40 healthy people were taken as the physical examination group. The control group was given prednisone and the dexamethasone group was treated with dexamethasone. The combination group was given dexamethasone combined with rituximab. CD4⁺CD25⁺ Treg cells were determined in all groups. The levels of CD4⁺CD25⁺ Treg cells were compared among the three groups and the physical examination group before the treatment. The levels of CD4⁺, CD25⁺ and CD127 Treg cells were compared among the three groups before the treatment and 2, 4 weeks after the treatment. The curative effect and recurrence were compared among the three groups.Methods　The levels of CD4⁺CD25⁺ Treg cells in the control group, dexamethasone group and combination group were significantly lower than those in the physical examination group. The above indicators were significantly increased after the treatment of 2 and 4 weeks than those before the treatment. The indicators were increased at first and then decreased in the control group and dexamethasone group, but they were gradually increased in the combination group and were significantly higher than those in the control group and dexamethasone group after the treatment of 4 weeks. The total effective rate of the combination group was significantly higher than that of the control group and dexamethasone group(P<0.01). The recurrence rate of the combination group(22.9%) was significantly lower than that of the control group and the dexamethasone group（P<0.01）.Conclusion　Large dose of dexamethasone combined with rituximab can effectively improve the levels of Treg cells, with a satisfactory long-term curative effect.]]> 2017/9/12 9:14:26 CUI Yun-xia 288true ［Abstract］　Objective　To study the promotion of lactation and uterine instauration and the influence of lochia and pelvic floor rehabilitation after natural birth, using portable low-frequency electrical stimulation therapy apparatus and to summarize its clinical application value.Methods　Six hundred cases with natural childbirth in hospital were randomly divided into the treatment group（n=300） and the control group(n=300).The treatment group was treated using portable low-frequency electrical stimulation therapy apparatus. The control group adopted postpartum breast-feeding mission, guiding the pelvic floor muscle training(Kegel exercise). Maternal postpartum lactation, uterine instauration and quantity of lochia and pelvic floor rehabilitation after the natural labor were compared beteen the two groups.Methods　The maternal postpartum lactation was promoted by portable low-frequency electrical stimulation therapy apparatus. Uterine instauration and reduced the volume of lochia and pelvic floor muscle strength improved better in the treatment group than those in the control group(P<0.05).Conclusion　The portable low-frequency electrical stimulation therapy apparatus can be used for promoting lactation, uterine instauration and lochia and pelvic floor rehabilitation after natural labor.]]> 2017/9/12 9:14:26 LU Cui-ying, ZHANG Xiao-ling, LI Zhi-qing, et al. 287true ［Abstract］　Objective　To explore the risk factors of perioperative concurrent epilepsy on patients with severe head injury and their countermeasures.Methods　Eighty patients with severe craniocerebral injury were collected in our hospital from January 2013 to January 2015, and their clinical data were retrospectively analyzed. The relationship between these factors and epilepsy in age, gender, class of brain damage, injured parts and nature of injury were analyzed. According to the characteristics of the risk factors, the related countermeasures were put forward.Methods　Single factor analysis showed that age, cerebral contusion, ruptured cerebral dura mater, pitting a skull fracture,intracranial hematoma were closely related to perioperative severe head injury complicated with epilepsy. Multiariable Logistic regression analysis showed that low age, frontal and parietal lesion, and accompanied by cerebral contusion hemorrhage, intracranial hematoma and subarachnoid gap are risk factors for severe craniocerebral injury complicated with perioperative epilepsy.Conclusion　Low age, cerebral contusion, ruptured cerebral dura mater, pitting a skull fracture, intracranial hematoma are risk factors for severe craniocerebral injury complicated with perioperative epilepsy. In response to these risk factors, countermeasures of early prevention and clinical perioperative observation and nursing are beneficial to reducing the occurrence of traumatic epilepsy.]]> 2017/9/12 9:14:26 HAN Xiao-ming, YOU Yu-juan, ZHOU Wen-jiang, et al. 286true ［Abstract］　Objective　To explore the curative effect of Tiotropium bromide combined with Symbicort turbuhaler on patients with stable COPD.Methods　One hundred patients with stable COPD were randomly divided into the observation group and the control group. The control group was given theophylline orally, and if necessary salbutamol aerosol atomization treatment was given. The observation group was given Tiotropium bromide and Symbicort turbuhale therapy. For two consecutive months after the treatment, the changes of lung function and blood gas were analyzed and compared between the two groups.Results　Lung function and blood oxygen saturation improved better in the observation group than those in the control group(P<0.05).Conclusion　Tiotropium bromide combined with symbicort turbuhale can obviously improve the stability state of pulmonary function in COPD patients and improve the prognosis of patients and the quality of life.]]> 2017/9/13 9:54:48 LI Xiao-wei, XUE Jian-zhen, LIU Xu 285true ［Abstract］　Objective　To investigate the effects of Yishenyangxuehuoxue decoction（YSYXHX decoction） on colporrhagia and menstruation after drug induced abortion.Methods　One hundred and forty-eight women with early pregnancy were selected, and divided into simple medical abortion group(n=47), medical abortion+traditional Chinese medicine group(n=50), operation abortion group(n=51). The simple medical abortion group was given oral mifepristone tablets. The medical abortion+traditional Chinese medicine group was given YSYXHX decoction based on the same treatment as the simple medical abortion group. The operation abortion group used vacuum aspiration abortion. The changes of reproductive hormone, vaginal bleeding duration, vaginal bleeding amount and occurrence of menstrual disorder were compared among the three groups during the follow-up period.Results　HCG, LH, P at the seventh days after discharge of gestational sac in the operation abortion group and in the medical abortion+traditional Chinese medicine group were significantly lower than those in the simple medical abortion group(P<0.05), and than those in the operation abortion group(P<0.05). The FSH, E2 at the seventh days after discharge of gestational sac in the operation abortion group and in the medical abortion+traditional Chinese medicine group were significantly higher than those in the simple medical abortion group. And than those in the operation abortion group(P<0.05). The rates of vaginal bleeding duration at 8～15 days and more than 15 days in the operation abortion group and the medical abortion+traditional Chinese medicine group were lower than those in the simple medical abortion group(P<0.05). The rates of abnormal vaginal bleeding in the operation abortion group and in the medical abortion+traditional Chinese medicine group were lower than that in the simple abortion group(P<0.05). The incidences of menstrual disorders in the operation abortion group and in the medical abortion+traditional Chinese medicine group at the end of the first, third, sixth months of the followup were significantly lower than those in the simple abortion group(P<0.05), while those in the medical abortion+traditional Chinese medicine group were lower than those in the operation abortion group(P<0.05).Conclusion　Yishenyangxuhuoxu decoction can shorten vaginal bleeding time, reduce blood losing and promate menstruation recovery.]]> 2017/9/13 9:54:48 LI Hai-xia 284true ［Abstract］　Objective　To study the effects of cinepazide maleate on inflammatory factors and neural functional defects in patients with acute cerebral infarction（ACI）.Methods　Eighty patients with ACI were randomly divided into two groups, with 40 cases in each group. The control group（n=40） was given routine treatment（dehydration, anticoagulation, protecting brain, hyperbaric oxygen and symptomatic treatment） and the observation group（n=40） was given cinepazide maleate based on the same treatment in the control group. Both of the two groups were treated for 14 days. The levels of IL-6, TNF-α, sICAM-1, MMP-9, infarct volume and NIHSS score were detected in each group before and after treatment and their clinical efficacy were evaluated.Results　After 14 days of the treatment, the efficacy was excellent in 19 cases, good in 14 cases, improved in 6 cases in the observation group, and invalid in 1 case; the efficacy counterparts in the control group were 10, 12, 10 and 8 respectively. The effect of the observation group was better than that of the control group（P<0.05）. There were no significant differences between the two groups in the levels of IL-6, TNF-α, sICAM-1, MMP-9, infarct volume and national institute health stroke scale（NIHSS） score before the treatment（P>0.05）. After 14 days of the treatment, the above indicators in the two groups were significantly improved than those before the treatment（P<0.01）, however the indicators were improved more obviously in the observation group（P<0.01）; There was no significant difference in the incidence of adverse reactions between the observation group（15%） and the control group（10 %）（χ²=0.4571, P>0.05）.Conclusion　Cinepazide maleate is safe and effective in the treatment of acute cerebral infarction. It can reduce infarction area, improve prognosis and reduce the levels of inflammatory factors （IL-6, TNF-α, sICAM-1, MMP-9）, which may be one of the mechanisms of action.]]> 2017/9/13 9:54:48 MA Xue-li 283true ［Abstract］　Objective　To analyse the levels of G6PD activity in different types of thalassemia in Guangxi and to study their association with thalassemia.Methods　One hundred and thirteen negative thalassemia samples and 248 different types of thalassemia samples were analyzed by gene analysis and were detected for G6PD activity.Results　The levels of G6PD activity was （6.76±2.28）U/gHb in the negative thalassemia group, （9.00±3.67 ）U/gHb in α thalassemia group, （10.98±6.25）U/gHb in β thalassemia group, and （9.09±2.96）U/gHb in αβ complex thalassemia group, with significantly differences compared with the negative thalassemia group（P<0.05）. The G6PD activity levels of α thalassemia in silent, trait and Hb H groups were （6.67±1.65）U/gHb,（8.89±2.12）U/gHb,（12.7±5.44）U/gHb respectively; of β thalassemia in trait and intermedia groups were （9.68±3.71）U/gHb and （18.43±10.71）U/gHb. There were significant differences in the levels of G6PD between the different types of α thalassemia and β thalassemia in α thalassemia and β thalassemia groups（P<0.05）.Conclusion　Different levels of G6PD activity go with different types of thalassemia, the more severe anemia the higher G6PD activity.]]> 2017/9/13 9:54:48 ZHAO Lin, WEN Nai-jian, NING Le-ping, et al. 282true ［Abstract］　Objective　To detect the expression levels of Th1/Th2 subpopulations and Th1 cytokines interleukin-2(IL-2), interferon-γ（IFN-γ) and Th2 cytokines IL-4, IL-6, IL-10 in the serum of patients with cervical carcinoma, hysteromyoma and the healthy controls, and to provide the basis for the early diagnosis of cervical cancer and cervical intrepithelium neoplasia.Methods　The peripheral blood was collected from 40 cases with cervical carcinoma, and other 40 cases with cervical intrepithelium neoplasia and 50 healthy people. Th1 cytokines interleukin-2(IL-2), interferon-γ（IFN-γ) and Th2 cytokines IL-4, IL-6, IL-10 in the serum of all cases were detected using ELISA kit. Flow cytometry was used to detect the ratio of Th1/Th2 subpopulations.Results　The expression levels of IL-2, IFN-γ decreased, and IL-4, IL-6, IL-10 increased, the ratio of Th1/Th2 decreased in the cervical cancer group and CIN group compared with those in the control group(P<0.05). Th1 cytokines reduced more and Th2 cytokines rose more in CIN group than those did in the cervical cancer group(P<0.05).Conclusion　Th1 cytokines decrease while Th2 cytokines increase, and the ratio of Th1/Th2 decreases in the patients with cervical cancer. The expression levels of Th1 and Th2 are associated with tumor pathological grade, which reveals that Th1/Th2 plays a vital role in the development of cervical carcinoma,and could be helpful to determine and monitor the tumors properly.]]> 2017/9/15 8:39:15 DONG Yong-zhan, WANG Xiang 281true ［Abstract］　Objective　To analyze the effect of noninvasive mechanical ventilation on the levels of serum BNP and ET-1 in patients with chronic pulmonary heart disease complicated with respiratory failure.Methods　Eighty patients with chronic pulmonary heart disease complicated with respiratory failure were collected and were randomly divided into the experimental group(n=40) and the control group(n=40). The control group was given conventional treatment and the experimental group was treated with additional noninvasive mechanical ventilation. The clinical curative rate, blood gas analysis and BNP and serum ET-1 levels were compared between the two groups 72 hours after the treatment.Results　The clinical symptoms, signs and blood gas analysis results improved significantly in the experimental group 72 hours after the treatment, among which SaO₂, PaO₂ significantly increased while PaCO₂, HR and RR decreased significantly(P<0.05). BNP and ET-1 levels of the experimental group decreased with the improvement of symptoms of hypoxia and carbon dioxide retention(P<0.01, P<0.05), which was significantly better than the control group. BNP and ET-1 levels were positively correlated. BNP and ET-1 and partial pressure of oxygen were negatively correlated. Pressure was positively correlated with carbon dioxide.Conclusion　Noninvasive mechanical ventilation can improve ventilation function in patients with chronic pulmonary heart disease complicated with respiratory failure, reduce the serum BNP and ET-1 levels and improve the clinical efficacy.]]> 2017/9/15 8:39:15 CHEN Xiong, CHEN Cui-xia, ZHANG Jing, et al. 280true ［Abstract］　Objective　To observe the curative effect of metformin in combination with dyne-35 on the treatment of polycystic ovary syndrome and on the ovulation rate and pregnancy rate.Methods　Sixty-eight patients with polycystic ovary syndrome in our hospital were randomly divided into group A and group B, with 34 cases in each group. Group A was given metformin combined with dyne-35 and then G′Finn after withdrawing the above medication. Group B was given G′Finn treatment alone. Both of the two groups were treated with 80 circles. The ovulation rate and the pregnancy rate were compared between the two groups.Results　Acne, amenorrhea and menstrual thin hair improved significantly in group A after the treatment(P<0.05), while hairy improvement was not obvious after the treatment(P>0.05). Reproductive endocrine hormones(FSH, LH, E2, T) of group A decreased obviously compared with those before the treatment(P<0.05). The similar results occurred in group B. There was no significant difference between group A and group B(P>0.05). The ovulation rate(72.50%) and pregnancy rate(32.35%) of group A were significantly higher than those of group B（53.75%, 8.82%）(P<0.05).Conclusion　In patients with polycystic ovary syndrome, using metformin combined with dyne-35 treatment can effectively improve irregular menstruation, acne, and symptoms such as high androgen signs, adjust the reproductive endocrine hormone level inside body, significantly increase the ovulation rate and pregnancy rate.]]> 2017/9/15 8:39:15 HAN Yu-feng 279true ［Abstract］　Objective　To investigate the clinical efficacy of atropine combined with omeprazole in the treatment of patients with acute gastritis.Methods　One hundred patients with acute gastritis were divided into the control group(n=50) and the observation group(n=50). The control group was treated with anisodamine combined with omeprazole, and the observation group was treated with atropine combined with omeprazole. The clinical efficacy was compared between the two groups.Results　The effective rate of the observation group was significantly higher than that of the control group(P<0.05). The incidence of adverse reactions was obviously lower in the observation group than that in the control group(P<0.05). The rate of significant efficiency for the first time after the medication in the observation group(76.0%) was significantly higher than that in the control group(44.0%)(P<0.05).Conclusion　Atropine combined with omeprazole is safe and effective in the treatment of acute gastritis, which quickly reduces the symptom of pain and improves the patients′ quality of life.]]> 2017/9/15 8:39:15 CHEN Tian-shan, LIANG Bo, HUANG Wei, et al. 278true ［Abstract］　Objective　To explore the clinical efficacy of internal fixation of proximal femoral nail anti-rotation(PFNA) on femoral trochanter fracture in the elderly patients.Methods　One hundred elderly patients with femoral intertrochanteric fracture in our hospital from January 2013 to January 2015 were randomly divided into the control group and the observation group, with 50 cases in each group. The control group was subjected to the reconstruction treatment of proximal femoral nail(PFN), and the observation group received the therapy of PFNA. The clinical efficacies of the two kinds of operation methods were compared.Results　The therapeutical effect of the observation group was better than that of the control group(P<0.05). The operation time, intra-operative blood loss, hospitalization and fracture healing time in the observation group were significantly less than those in the control group(P<0.01).Conclusion　Internal fixation of PFNA is highly efficacious and simple for the elderly patients with femoral trochanter fracture.]]> 2017/7/13 10:28:25 SONG Jun-jie 277true ［Abstract］　Objective　To observe the incidences of postoperative intestinal adhesion in open cholecystectomy and laparoscopic cholecystectomy.Methods　One hundred and ten patients with gallstones were collected as the research subjects from November 2012 to November 2014 and were divided into two groups according to the random number table. Group A(n=55) was treated with open cholecystectomy, and group B(n=55) was treated with laparoscopic cholecystectomy. All cases were followed up for one year. The incidences of postoperative adhesion was compared between the two groups.Results　The operating time, postoperative gastrointestinal function recovery time and time in group A were significantly longer than those in group B(P<0.05). The blood loss of group A was significantly more than that of group B(P<0.05). The incidence of postoperative intestinal adhesion of group A(61.82%) was significantly higher than that of group B(7.27%)(χ²=38.4368, P<0.05).Conclusion　Laparoscopic surgery has better effects and less complications than open cholecystectomy in the treatment of gallstone.]]> 2017/7/13 10:28:25 LIAN Fu-zhen 276true ［Abstract］　Objective　To investigate the clinical effect of endoscopy-laparoscopy in the treatment of severe acute pancreatitis complicated with pancreatic pseudocyst(PPC).Methods　Fifty-two cases with severe acute pancreatitis complicated with PPC were collected in our hospital from October 2014 to October 2015, and were randomly divided into the control group(n=26) and the experimental group（n=26）. The control group was treated with laparotomy surgery and the experimental group received endoscopic-laparoscopic surgery. The clinical efficacy was compared between the two operations.Results　The operation time, blood loss, exhaust time and hospital stay in the experimental group, were significantly shovter or less than those in the control group(P<0.05). The clinical efficacy of the experimental group was significantly better than that of the control group(P<0.05); There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion　Endoscopic-laparoscopic surgery is safe and effective in the treatment of severe acute pancreatitis complicated with PPC.]]> 2017/7/13 10:28:25 WANG Xiao-guang 275true ［Abstract］　Objective　To investigate the safety and feasibility of Ensite non-contact mapping system in guiding mapping and ablation of right ventricular outflow tract premature ventricular contractionss（PVCs）.Methods　Tirty-three patients with right ventricular outflow tract PVCs, aged (45 ± 13)years, including 12 males and 21 females were recruited in this study. A non-contact mapping array balloon catheter was successfully deployed in right ventricular chamber, which was reconstructed in three dimensions. The origin and breakthrough sites of PVCs were mapped according to the virtual monopole potential diagram. Catheter ablation was delivered in the origin and breakout sites.Results　The success rate of acute ablation was 97.0%(32/33), with a failure in one case and pericardial effusion in another case. Twenty-three cases were in the fast response pattern and 10 cases in the slow response pattern. One case relapsed during the follow-up of 6 months.Conclusion　The Ensite non-contact mapping is a safe and efficient method for guiding the ablation of right outflow tract PVCs. There are two different response patterns after the initiation of the earliest activation. The origin and breakthrough sites of PVCs in the fast response pattern are relatively fixed and they are often changed in the slow response pattern after catheter ablation.]]> 2017/7/13 10:29:15 QIN Shao-ming, WEI Kai-fu, HU Chang-xing, et al. 274true ［Abstract］　Objective　To observe the clinical value of minimally invasive hematoma puncture suction drainage in the treatment of severe hypertensive intracerebral hemorrhage.Methods　Thirty-five patients with hypertensive intracerebral hemorrhage were collected in our hospital from January 2012 to January 2014 and randomly divided into two groups. The observation group(n=18) received minimally invasive hematoma puncture suction drainage, and the control group(n=17) received the conventional treatment of craniotomy. The operation time, intraoperative blood loss, clinical efficacy, and NIHSS were compared between the two groups.Results　The operation time of the observation group［(47.9±6.7)min］ was significantly shorter than that of the control group［(91.5±11.8)min］（P<0.01）; The intraoperative blood loss of the observation group［(120.8±28.7)ml］ was significantly less than that of the control group［(291.5±71.4)ml］（P<0.01）; The NIHSS of the observation group(13.4±9.5) was significantly less than that of the control group(25.2±11.2)（P<0.01）; The clinical efficacy of the observation group was better than that of the control group（P<0.05）.Conclusion　The minimally invasive hematoma puncture suction drainage is simple, safe, and effective for the treatment of hypertensive intracerebral hemorrhage.]]> 2017/7/13 10:29:15 ZHANG Zhong 273true ［Abstract］　Objective　To explore the effect of pleth variability index(PVI) on the recovery of the patients with shock.Methods　Thirty-four cases with shock were recruited in this study. The resuscitation program was implemented according to the PVI values, and the relationship between SvO₂, CVP and PVI was observed.Results　All of the patients improved obviously 3 days after the treatment, and there was a negative correlation between PVI and SvO₂, CVP(P<0.01).Conclusion　PVI plays an important role in the recovery of the patients with shock.]]> 2017/7/13 10:29:15 YANG Tao 272true ［Abstract］　Objective　To explore the surgical bleeding risk of finasteride combined with tranexamic acid on the patients undergoing open retropubic radical prostatectomy(ORRP).Methods　Sixty-eight patients undergoing ORRP in Gongan Hospital of Traditional Chinese Medicine were randomly divided into the observation group and the control group, with 34 cases in each group. The patients in the observation group were orally administered with finasteride two weeks before the operation and 3 days after the operation on basis of the routine preoperative preparations, and were subjected to intravenous application of tranexamic acid during the operation and 3 days after the operation. The patients in the control group received the routine preoperative preparation and postoperative treatment. The bleeding amount, bleeding index, bleeding intensity, average daily blood loss and the time of washing bladder within 3 days after the operation were compared between the two groups.Results　All the above indexes of the observation group were significantly lower or shorter than those of the control group(P<0.05).Conclusion　Finasteride combined with tranexamic acid can effectively reduce the bleeding risk in the patients undergoing ORRP.]]> 2017/7/13 10:29:15 DING Cai-xue 271true ［Abstract］　Objective　To study the effect of a small dose of adrenaline combined with isoproterenol on the treatment of bronchiolitis.Methods　Ninety-eight bronchiolitis patients were randomly divided into two groups, with 49 cases in each group. The observation group was given a small dose of adrenaline combined with isoproterenol, and the control group was given theophylline. The clinical symptoms disappeared time, pulmonary function and clinical efficacy after the treatment were compared between the two groups.Results　The cyanosis disappearance time, wheezing disappearance time, cough disappearance time, moist rale disappearance time and hospital stay of the observation group were less than those of the control group. The respiration ratio(Ti/Te) was significantly lower in the observation group than that in the control group, P<0.01; while tidal volume, TPTEF/TE and VPEF/VE were significantly higher in the observation group than those in the control group(P<0.01); 27 cases were markedly effective, 20 cases effective, 2 cases invalid in the observation group, while 20 cases were markedly effective,18 cases effective, 11 cases invalid in the control group, with a significant difference between the two groups(P<0.05).Conclusion　Low-dose epinephrine and isoproterenol can be safe and effective to relieve bronchiolitis wheezing quickly, and dyspnea and improve the lung function.]]> 2017/7/13 10:29:15 LIU Yuan-lin 270true ［Abstract］　Objective　To observe the clinical efficiency of rhubarb retention enema on acute cerebral infarction combined with disturbance of consciousness.Methods　Acute massive cerebral infarction was diagnosed by CT or MRI in 60 patients with disturbance of consciousness within 24 hours of onset, and the patients were randomly divided into two groups. The control group(n=30) received the conventional medical management of western medicine. The experimental group(n=30) was treated with rhubarb retention enema 60 g once every two days for 14 days based on the treatment in the control group.Results　The efficiency of the experimental group was significantly higher than that of the control group(P<0.05).Conclusion　Rhubarb retention enema combined with the conventional medical management of western medicine is effective for the patients with acute cerebral infarction combined with disturbance of consciousness.]]> 2017/8/4 9:07:51 HE Jian-hua, SONG Zi-xian, HUANG Bin 269true ［Abstract］　Objective　To explore the clinical effects of budesonide aerosol inhalation therapy on the cough following mycoplasma pneumonia infection.Methods　One hundred and twenty patients with cough following mycoplasma pneumonia infection were randomly divided into two groups, with 60 cases in each group. The control group recieved the conventional treatment of cough after conventional pneumonia infection, the treatment group recieved the conventional budesonide aerosol inhalation therapy, and cough symptom scores were compared between the two groups before and 14 days after the treatment.Results　There was no statistically significant difference before treatment between the two groups(P>0.05), and cough scores in the treatment group were significantly lower than those in the control group(P<0.05); The clinical efficacy of the treatment group was significantly higher than that of the control group(P<0.05). The hospitalization duration and cough disappearance time in the control group were significantly shorter than those in the control group(P<0.05).Conclusion　Budesonide therapy applied on patients with cough following mycoplasma pneumonia infection can effectively improve cough symptom, shorten their hospitalization duraiton, and reduce the pain on patients.]]> 2017/8/4 9:07:51 LIANG Xu-man 268true ［Abstract］　Objective　To explore the clinical effect of alprostadil combined with benazepril on the patients with diabetic nephropathy and proteinuria.Methods　Eighty-six patients with diabetic nephropathy and proteinuria admitted to our hospital from August 2014 to October 2015 were selected as the research subjects and were divided into the control group and the observation group according to the different treatment methods, with 43 cases in each group. The control group was treated with benazepril, and the observation group was treated with alprostadil combined with benazepril. The contents of urinary protein and the excretion rate of urine albumin were detected before and 24 h after the treatment. The clinical effect and adverse reactions were compared between the two groups.Results　The total effective rate of the observation group(93.0%) was significantly higher than that of the control group(72.1%)(P<0.05). There were no significant differences in the contents of urine protein and the excretion rate of urinary miro-albumin between the two groups before the treatment(P>0.05). The contents of urine protein and the excretion rate of urinary micro-albumin in both of the two groups after the treatment were significantly lower than those in both of the two group befor the treatment(P<0.05). The clinical effect of the observation group was better than that of the control group（P<0.05）. There was no significant difference in the incidence of adverse reactions between the observation group(9.3%) and the control group(11.6%)(P>0.05).Conclusion　Alprostadil combined with benazepril is safe and effective in the treatment of proteinuria associated with diabetic nephropathy, and effectively improves the clinical symptoms of patients, reduces the content of urinary protein, improves the renal function and the quality of life, and enhances the efficacy with high safety and less adverse reactions in patients with diabetic nephroparty and proteinuria.]]> 2017/8/4 9:07:51 CHEN Qin-hong 267true ［Abstract］　Objective　To explore the clinical effect of nasal continuous positive airway pressure(NCPAP) on hyaline membrane disease(HMD) in neonates.Methods　Seventy-six neonates with HMD were randomly divided into two groups. The research group(n=39) was treated with NCPAP, and the control group(n=37) was treated with the conventional mechanical ventilation.The changes of pappenheimer O₂, pappenheimer CO₂ and ventilator associated lung injury, nasal mucosal injury, oxygen therapy time, hospital stay, hospitalization costs, and total effective rate were compared between the two groups.Results　Compared with those before the treatment, pappenheimer O₂ and pappenheimer CO₂ were significantly improved in both of the two groups after the treatment(P<0.05). There were no significant differences in the partial pressure of oxygen and pappenheimer CO₂ at all the time points after the treatment between the two groups(P>0.05). The incidences of complications such as ventilator associated lung injury and nasal mucosal injury in the research group were significantly lower than those in the control group(P<0.05). The oxygen therapy time, hospital stay and hospitalization costs in the research group were significantly less or lower than those in the control group(P<0.05). In the research group,16 cases were markedly effective, 21 cases effective, 2 cases invalid; In the control group,14 cases were markedly effective, 20 cases effective, 3 cases ineffective, with no significant difference betweent the two groups(P>0.05).Conclusion　NCPAP has similar clinical effect to the conventional mechanical ventilation on HMD in neonates. However, nasal continuous positive airway pressure can reduce the incidence of complications and the hospitalization costs, shorten the time of the oxygen and hospital stay.]]> 2017/8/4 9:07:51 CHEN Mei-fang, TAN Guan 266true ［Abstract］　Objective　To explore the clinical effects of different operations on intertrochanteric fractures.Methods　One hundred and four cases with intertrochanteric fracture in our hospital from January 2013 to December 2014 were randomly divided into the control group(n=52) and the observation group(n=52). The observation group was treated with Dynamic Hip screws and the control group was given proximal femoral intramedullary nailing. The clinical effect and Harris scores were compared between the two groups.Results　(1)There were no significant diflerences in the operation time and intraoperative blood loss between the two groups(P>0.05). (2)The fracture healing time of the observation group was significantly shorter than that of the control group(P<0.05). There was no statistically significant difference in the incidence of complications between the two groups(P>0.05). (3)After the treatment, Harris scores were significantly improved in both of two groups, however Harris scores in the observation group is higher than those in the control group(P<0.05).Conclusion　PFN is more effective that DHS in the treatment of intertrochanteric fractures.]]> 2017/8/4 9:07:51 ZHENG Feng, SHEN Ye-guang, HUANG Kai, et al. 265true ［Abstract］　Objective　To investigate the effects of different doses of adrenal cortex hormone on acute severe infection in children.Methods　Ninety children with acute severe infection treated in our hospital from March 2012 to March 2015 were collected as the study objects. All patients were treated with antibiotics combined with adrenal cortical hormone. According to different doses of adrenal cortical hormone, the patients were divided into the high-dose group(6～10 mg·kg^-1·d^-1), middle-dose group(3～5 mg·kg^-1·d^-1) and low-dose group(1～2 mg·kg^-1·d^-1), with 30 cases in each group. The time of body temperature recovery, the incidence of complications, CRP, erythrocyte sedimentation and the other indexes were compared among the three groups before and after the treatment.Results　CRP, WBC and erythrocyte sedimentation in the three groups after the treatment were significantly lower than those before the treatment(P<0.05), but the differences were not significant among the three groups after the treatment(P>0.05). The time of body temperature recovery and the incidence of complications in the high-dose group were （2.8±0.2）d and 26.7%, respectively. Compared with those in the middle-dose group and the low-dose group, the differences were statistically significant(P<0.05).Conclusion　Adrenal cortical hormone can significantly reduce the inflammatory reactions in children with acute severe infection. Middle dose of adrenal cortical hormone is recommended.]]> 2017/8/4 9:07:51 YANG Pei-na 264true ［Abstract］　Objective　To investigate the clinical efficacy of atorvastatin combined with trimetazidine in the treatment of stable angina pectoris of coronary heart disease.Methods　Ninety-eight patients with stable angina pectoris of coronary heart disease in our hospital were selected from January 2014 to January 2015. The patients were divided into the observation group and the control group, with 49 cases in each group. The control group was treated with trimetazidine and the observation group was treated with atorvastatin combined with trimetazidine. All patients were treated for 8 weeks.Results　In the observation group, 22 cases were markedly effective, 24 cases effective, 3 cases ineffective after the treatment, In the control group,18 cases were effective, 20 cases effective, 11 cases ineffective. The clinical efficacy of the observation group was significantly higher than that of the control group, P<0.05, and the time of LMM and ST in patients of the observation group was better than that of the control group and the incidence of adverse reactions was lower than that of the control group(P<0.05).Conclusion　Atorvastatin combined with trimetazidine can significantly improve the clinical symptoms of the patients with angina pectoris of coronary heart disease.]]> 2017/8/4 9:07:51 FAN Fo-yuan 263true ［Abstract］　Objective　To explore the effect of atorvastatin on serum C-reactive protein(CRP) and lipids in patients with acute cerebral infarction.Methods　Sixty-six cases with acute cerebral infarction were randomly divided into two groups. The control group(n=32) received the conventional treatment for cerebral infarction, and the observation group(n=34) received an additional daily dose of 20 mg atorvatation on the basis of the conventional treatment for four weeks. The levels of serum CRP and lipids were compared between the two groups.Results　The levels of TC and LDL-C were decreased and the level of HDL-C elevated signigicantly after the treatment in the observation group(P<0.05). There were no signigicant differeces in the levels of TC, LDL-C and HDL-C in the control group(P>0.05). Compared with those in the control group, the levels of TC and LDL-C were lower and the level of HDL-C eleveted signigicantly in the observation group after the treatment(P<0.05). Compared with those before the treatment, the levels of serum CRP and neurological deficit scores were signigicantly decreased in both of the two groups after the treatment(P<0.05). Compared with those in the control group, the level of serum CRP and neurological deficit score were signigicantly lower in the observation group(P<0.05).Conclusion　Atovastatin can obviously improve the levels of serum CRP and lipids in patients with acute cerebral infarction.]]> 2017/8/4 9:07:51 LIAO Xi, LIANG Yuan 262true ［Abstract］　Objective　To study the mental health and influence factors in adolescent patients with cleft lip and palate(CLP).Methods　A case control study was carried out in 70 adolescent patients with CLP and 50 controls, in which a self-design questionnaire was used to investigate the mental health status and the influence factors. The data were analyzed by multiple logistic regression analysis.Results　The patients with CLP had significantly higher scores of Symptom Checklist 90 than those in the control group in interpersonal sensitivity, depression, anxiety, number of positive items and aggregate sore(P<0.05). The incidence of anxiety disorders in patients with CLP(45.7%) was significantly higher than that in the control group(4.0%)(P<0.05). Multiple logistic regression analysis showed that males（OR=0.117）, and city dwellers（OR=0.187） had lower risks to get anxiety disorders, and the patients with cleft lip and palate（OR=4.813） had a higher risk to get anxiety disorders than those with single cleft lip or palate.Conclusion　The patients with CLP have poor mental health. It is necessary to strengthen the psychological and behavioral intervention for them.]]> 2017/8/4 9:07:51 LIANG Mei 261true ［Abstract］　Objective　To study the efferts of a small dose of Diazepam combined with Mosapride in the children with functional dyspepsia.Methods　One hundred and ten patients with functional dyspepsia were randomly divided into the observation group and the control group, with 55 cases in each group. The control group was treated with Domperidone and the observation group received a small dose of diazepam combined with Mosapride. The curative effect was compared between the two groups.Results　There were no significant differences in symptom scores, gastric emptying rate, plasma motilin and gastrin between the two groups before the intevention(P>0.05). There were significant differents between the observation group and the control group in symptom scores［（1.13±0.17） vs （2.14±0.46） ponints］, gagtric empty rate［（76.18±17.29） vs （56.14±13.89 )］%, plasmamotilin［(387.31±42.69） vs （303.76±30.76）］ng/L and gastrin［(58.26±10.01） vs （39.67±5.79）］ng/L, P<0.01.Conclusion　A small dose of Diazepam combined with Mosapride is effective in children with functional dyspepsia. It can improve the clinical symptoms and increase the levels of plasma motilin and serum gastrin in the patients.]]> 2017/8/4 9:07:51 GAO Ruo-fei 260true ［Abstract］　Objective　To explore the clinical effect of ritodrine hydrochloride combined with atosiban in the treatment of premature birth.Methods　Eighty patients with premature birth were collected as the research subjects, and divided into the control group and the observation group, with 40 cases in each group, according to the different therapy methods. The control group received ritodrine hydrochloride, and the observation group was administrated atosiban in addition to the routine treatment that was applied to the control group. The clinical effect and the adverse reactions were compared between the two groups.Results　The effect of inhibition of uterine contraction in the observation group was significantly better than that in the control group(P<0.01). The incidence of adverse reactions in the observation group（15.0%） was significantly lower than that in the control group（42.5%）, P<0.01. The disappearance time of uterine contraction, pregnancy extension duration and neonatal weight in the observation group were better than those in the control group(P<0.05). There was no significant difference in the survival rate of the infants between the two groups（97.5% vs 90.0%）, P>0.05.Conclusion　Ritodrine hydrochloride combined with atosiban can effectively suppress the uterine muscle contractions in patients with premature birth, improve the clinical symptoms, extend the gestational age of fetuses and improve the survival quality of fetuses in patients with premature birth.]]> 2017/8/8 16:30:41 CHEN Chun-yan 259true ［Abstract］　Objective　To compare the efficacy between epidural anesthesia and combined spinal-epidural anesthesia for labor analgesia.Methods　Ninety-two cases of primiparas were randomly divided into the epidural group(n=45) and the combined spinal-epidural group(n=47). The VAS pain score, the onset and duration time of analgesic, the time of stages,Apgar scores of neonatal, the rate of cesarean delivery and the rate of oxytocin′s usage were observed and compared between the two groups.Results　 The VAS pain scores at T₁, T₂, T₃, T₄ and T₅ were signigicantly lower than those at T₀ in both of the two groups(P<0.05). The VAS pain scores at T₁, T₂ and T₃ in the combined spinal-epidural group were signigicantly lower than those in the epidural group(P<0.05). The onset duration time of analgesic, the rate of cesarean delivery and the rate of oxytocin′s usage in the combined spinal-epidural group were signigicantly shorter or lower than those in the epidural group(P<0.05). However, there were no signigicantl differences in time of stages and Apgar scores of neonatal and the duration time of analgesic between the two groups(P>0.05).Conclusion　Combined spinal-epidural anesthesia has both advantages of epidural anesthesia and lumbar anesthesia for labor analgesia.]]> 2017/8/8 16:30:41 HE Ping, LI Qing-song 258true ［Abstract］　Objective　To study the clinical effect of nasal bilevel positive airway pressure ventilation on treating apnea of prematurity.Methods　Sixty-two premature infants with primary apnea were randomly divided into the control group and the study group, with 31 cases in each group. The control group was given nCPAP and the study group was given nBiPAP on the basis of the routine treatment. If the treatment was not effective in the two groups, endotracheal intubation and mechanical ventilation were used. The remission rate of apnea, the hospitalization time, the total time of using oxygen, the rate of endotracheal intubation and the complications were compared between the two groups.Results　The remission rate of apnea of prematurity in the study group(61.3%) was higher than that in the control group(35.5%). The rate of endotracheal intubation in the study group(9.7%) was lower than that in the control group(32.3%)(P<0.05). There were no signficant differences in the hospitalization time, the total time of using oxygen, pneumothorax, abdominal distention, nasal skin damage and intracranial hemorrhage between the two groups(P>0.05).Conclusion　Nasal bilevel positive airway pressure ventilation is safe and effective on treating apnea of prematurity.]]> 2017/8/10 9:01:20 ZHAO Quan-en, LIAO Pei-chan 257true ［Abstract］　Objective　To explore the effect of cisapride combined with Danshitong capsule in the treatment of senile functional constipation.Methods　One hundred and twenty patients with senile functional constipation, were randomly divided into the observation group and the control group, with 60 cases in each group. The control group received cisapride for treatment and the observation group was treated with cisapride in combination with Danshitong capsules. The curative effect was compared between the two groups 2 weeks after the treatment.Results　There were significant differences in the minimum amount sensitive to rectum (164.52±10.79)ml vs (180.67±18.57)ml, in maximum tolerance (231.64±23.61)ml vs (252.86±31.46)ml between the observevation group and the control group(P<0.05). The times of bowel movements per week and scores of stool consistency in the observation group were significantly more than those in the control group ［(3.87±1.22） vs （3.11±0.74） and （2.72±0.89） vs （1.94±0.48)］. The score of dyschesia in the observation group（1.67±0.16） was significantly less than that in the control group(2.13±0.58),(P<0.05).Conclusion　Cisapride in combination with Danshitong capsule can effectively improve the anal sensation, promote the anorectal coordinating contraction, improve the bowel condition and symptoms in the treatment of functional constipation in the elderly.]]> 2017/8/10 9:01:20 PENG Jing-shi 256true ［Abstract］　Objective　To investigate the relationship between the expressions of TCF21 and Caspase-3 and the clinicopathological features in non-small cell lung cancer(NSCLC).Methods　44 samples coming from both adjacent and cancer tissues were collected from the People′s Hospital of Binyang County in Guangxi during 2013 to 2015. Real-time PCR(RT-PCR) was used to assay the expressions of TCF21 and Caspase-3 in lung cancer and normal tissues, and the relationship between the expressions of TCF21 and Caspase-3 and the clinicopathological features in NSCLC was analyzed.Results　The expressions of TCF21 and Caspase-3 in NSCLC tissues were significantly lower than those in the matched normal lung tissues［(0.36±0.70） vs （1.00±0.00）, （0.62±0.56） vs （1.00±0.00）, P<0. 05］. The levels of TCF21 and Caspase-3 expressions were significantly lower in the mid-term lung cancer TNM Ⅲ than those in TNM Ⅰ+Ⅱ［（0.05±0.06） vs （0.48±0.79）, （0.17±0.20） vs （0.78±0.56）, P<0.01］. There was a positive correlation between the expressions of TCF21 and Caspase-3 in NSCLC. Conclusion　 The low expressions of TCF21 and Caspase-3 may aggravate the malignant hyperplasy and metastasis of tumor, combined detection of the expressions of TCF21 and Caspase-3 plays an important role in evaluating the degree of malignancy, and predicting the potential metastasis and prognosis of NSCLC.]]> 2017/8/10 17:32:15 LI Shou-nan, XIAN Lei, WU Zheng-qiu, et al. 255true ［Abstract］　Objective　To study the clinical effects of distal clavicular microporous locking plate and hook-shaped plate fixation in the treatment of distal clavicular fractures.Methods　One hundred and twenty cases with distal clavicular fractures in our hospital were divided into the observation group and the control group by the random number table method, with 60 cases in each group. The observation group received distal clavicular microporous locking plate for the treatment while the control group was treated with distal clavicular hook-shaped plate internal fixation. The clinical curative effect, operative indexes, DASH score of upper limb function and Constant score of shoulder function were compared between the two groups.Results　The total effective rate in of the observation group(96.67%) was significantly higher than that of the control group(83.33%)(P<0.05). There were no significant differences in the operative time, length of stay in the hospital, amount of bleeding and fracture healing time between the two groups(P>0.05). DASH score of the observation group(3.15±0.94) was significantly lower than that of the control group(5.61±1.52)(P<0.01). Constant score of the observation group(91.58±4.77) was significantly higher than that of the control group(82.54±4.17)(P<0.01).Conclusion　Distal clavicular microporous locking plate and hook-shaped plate fixation are both effective methods in the treatment of distal clavicular fractures. Distal clavicular microporous locking plate is more effective than hook-shaped plate fixation in improving joint function.]]> 2017/8/10 17:32:15 ZHANG Hui 254true ［Abstract］　Objective　To evaluate the clinical efficacy of fissure resection surgery plus sphincter lysis in the treatment of anal fissure.Methods　One hundred and twenty patients with anal fissure were admitted to the Fifth People′s Hospital of Dongguan City from June 2013 to November 2014 and were divided into the control group(n=60) and the observation group(n=60) by a simple random method. The control group was performed fissure resection surgery and the observation group were performed fissure resection surgery plus sphincter lysis surgery. The clinical effective rates and the incidences of Ⅱ～Ⅲ postoperative pain, blood stool, dysuria were compared between the two groups. The patients were followed up and the incidences of relapse and infection were compared between the two groups.Results　The effective rate of the observation group(100.00%) was significantly higher than that of the control group(90.00%); The incidence of Ⅱ～Ⅲ postoperative pain, blood stool, dysuria and the follow-up recurrence rate of infections in the observation group were significantly lower than those in the control group（P<0.05）.Conclusion　Fissure resection surgery plus sphincter lysis surgery has significant effects on healing wound, reducing complications, improving patients′ compliance and relieving patients′ pain in the treatment of and fissure.]]> 2017/8/10 17:32:15 CHEN Hui-guo 253true ［Abstract］　Objective　To explore the curative effect of locking plate fixation in the treatment of complex tibial plateau fractures.Methods　Fifty-seven patients with complex tibial plateau fractures were randomly divided into two groups. The patients in the locking plate fixation group(n=29) received locking plate inernal fixation treatment, and the patients in the double plate fixation groups(n=28) received double-incision double-plate internal fixation treatment. The effects of the operation were compared between the two groups.Results　The operative time, full weight bearing time, hospitalization time and the healing time of fractures in the locking plate fixation group were significant shorter than those in the double plate fixation group(P<0.05). There were not signigicant differentces in the knee joint activity, PA, TPA and the excellent rate of knee fracture between the two groups 6 months after the operation(P>0.05).Conclusion　The locking plate fixation can obtain as similar clinical effect as double incision double plate fixation can in the treatment of complex tibial plateau fractures. It can provide continuous and stable inernal fixation, and the full weight bearing time and the healing time of fractures in the locking plate internal fixation are shorter.]]> 2017/8/10 17:32:15 LIAO Yan-jun 252true ［Abstract］　Objective　To investigate the value of cerebral blood source of nerve neurotrophic factor(BDNF), homocysteine(Hcy) and somatostatin(SS) combined with monitoring in the diagnosis post-stroke vascular dementia(VD).Methods　Thirty patients with VD after stroke were selected as VD group, 30 patients with cerebral apoplexy(non vascular dementia) as stroke group and 30 healthy people as the control group. The risk factors and related history of the VD group and the stroke group were analyzed, and the differences of Hcy, SS and BDNF were compared among the three groups and the levels of SS, Hcy and BDNF were compared among the three subgroups of the VD group with different levels of severity of VD.Results　(1)There was significant difference in the history of hypertension between the VD group and the stroke group(P<0.05);(2)The levels of serum BDNF and SS in the VD group were lower than those in the stroke group and the control group(P<0.01); serum level of Hcy in the VD group was significantly higher than that in the stroke group and the control group(P<0.01);(3)The levels of serum BDNF, Hcy and SS among different levels of severity in VD patients were significant different(P<0.01).Conclusion　The levels of serum SS, Hcy and BDNF are beneficial to the early diagnosis and assessment of the severity of vascular dementia.]]> 2017/8/30 17:15:12 LI Shao-hui, LI Mao-qing, ZHONG Jun-jie 251true ［Abstract］　Objective　To investigate the imaging characteristics of cesarean scar pregnancy(CSP) and the clinical effect of uterine artery chemoembolization(UACE) on CSP.Methods　We retrospectively analyzed the clinical data of 26 patients with CSP who were admitted to our hospital from January 2010 to October 2014.The imaging characteristics of CSP and its clinical significance were analyzed. Uterine artery super selective intubation was carried out in all patients with a local perfusion of methotrexate(MTX) 50 mg and Gentamycin 80 000 units. After the injection, the embolization of uterine artery was achieved with the gelatin sponge. Uterus curettage was performed in all patients within 24 to 72 hours after the embolization.Results　The imaging characteristics of CSP can provide basis for postoperational individualized treatment. The successful rate of UACE was 100%. The bleeding volume in uterus curettage was between 50 and 150 ml. No serious complications were found.Conclusion　UACE combine with uterus curettage can significantly reduce the risk of uterectomy and infertile.]]> 2017/8/30 17:15:13 ZHOU Man-tian, WU Jian, HU Li-nan, et al. 250true ［Abstract］　Objective　To evaluate the effects of Alprostadil combined with Mecobalamin on Wanger 1～3 level of type 2 Diabetic foot(DF).Methods　Fifty-two patients with Wanger 1～3 level of type 2 DF were randomly divided into the treatment group(n=26) and the control group(n=26). The treatment group received Alprostadil injection(10 μg+250 ml NS, ivgtt) and Mecobalamin injection(0.5 mg+100 ml NS, ivgtt), and the control group received Mecobalamin injection(0.5 mg+100 ml NS, ivgtt). Both of the two groups were treated for 4 weeks and their clinical outcomes were evaluated.Results　The baseline information was similar between the two groups（P>0.05）. Seventeen cases were cured, 7 cases improved, 1 case invalid and 1 case deteriorated in the treatment group. Eight cases were cured, 9 cases improved, 7 cases invalid and 2 cases deteriorated in the control group. There was significant difference in the clinical total curative effect between the two groups(P<0.05). Compared with the same symptoms in the control group, the symptoms of claudication, swelling, pain and hemodynamics were improved in the treatment group after the treatment, and the treatment group were markedly better than the control group in improving the symptoms of claudication, pain and hemodynamics. The peak flow rate of popliteal and dorsal pedal arteries was significantly quicker after the treatment than that before the treatment in the treatment group, which was superior to that in the control group(P<0.05). No severe adverse reactions were found in the two groups.Conclusion　Alprostadil combined with Mecobalamin can significantly improve the limb blood supply, alleviate the symptoms of pain, swelling and claudication, which is an effective and safe therapy for Wanger 1～3 level of type 2 DF.]]> 2017/8/30 17:15:13 ZOU Wen-bing 249true ［Abstract］　Objective　To compare the clinical efficacy between laparotomy and laparoscopic surgery for the treatment of ovarian cyst.Methods　Two hundred inpatients with ovarian cyst were collected in our hospital from January 2012 to January 2015 and divided into the observation group(n=100, by laparoscopic surgery) and the control group(n=100, by traditional laparotomy). The clinical efficacies and complication rates were compared between the two groups.Results　The operation time, intra-operative blood loss, postoperative exhaust time and hospital stay were significantly lower in the observation group than those in the control group(P<0.05). The effective rate of observation group(98.0%) was significantly higher than those of the control group(89.0%), P<0.05. The incurrence rate of complications in the observation(2.0%) was significantly lower than in the control group(15.0%), P<0.05.Conclusion　Laparoscopic surgery has more advantages than traditional laparotomy in the treatment of ovarian cyst, including minor trauma, shorter operation duration, less blood loss, fewer complications and faster recovery.]]> 2017/8/30 17:15:13 LIANG Wei-yan 248true ［Abstract］　Objective　To explore the clinical efficacy of the emergent drilling on the skull bone and sequential dura incision in the treatment of the severe head injury with cerebral hernia.Methods　Sixty-four cases with severe head injury and cerebral hernia who received surgical treatment in our hospital from January 2012 to December 2014 were randomly divided into group A and group B by the random number table method. Group A received an emergent drilling on the skull bone, a standard decompressive craniectomy and the sequential dura incision. Group B received the standard decompressive craniectomy and the one-time dura incision. The incidence of acute encephalocele, the change of the pupil size and the prognostics after sixth months of the surgery were compared between the two groups.Results　The acute encephalocele was found in 7 cases(21.88%) in group A, and 18 cases(56.25%) in group B, with a significant difference(P<0.01). The normal pupils were found in 10 cases(31.25%), the contracted pupils in 18 cases(56.25%) and no change in 4 cases(12.50%) in group A. The counterpart changes occurred in group B were 5 cases(15.63%) in normal pupils, 13 cases(40.63%) in contracted pupils and 14 cases(43.75%) without changes. The changes of the pupil size of group A improved better than those of group B(P<0.05). In group A, 2 cases(6.25%) died, 2 cases（6.25%） were in vegetative state, 8 cases（25.00%） were severely disable, 8 cases(25.00%) were mildly disable and 12 cases(37.50%) recovered well. In group B, 6 cases(18.75%) died, 5 cases(15.63%) were in vegetative state, 9 cases(28.13%) were severely disable, 7 cases(21.88%) were mildly disable and 5 cases(15.63%) recovered well. Group A recovered better than group B(P<0.05).Conclusion　The emergent drilling on the skull bone and sequential dura incision have significant effects on reducing the intracranial pressure. They can reduce the incidence of the acute encephalocele, improve prognosis and reduce the mortality and morbidity rates.]]> 2017/9/1 11:34:47 HAN Xiao-ming, CHAI Feng, ZHOU Wen-jiang, et al. 247true ［Abstract］　Objective　To observe the clinical effect of vertebral arch bone grounding on the treatment of thoracolumbar spine burst fracture.Methods　Forty-five patients with thoracolumbar spine burst fractures admitted to Foshan Hospital of Traditional Chinese Medicine from May 2013 to May 2014 were randomly divided into the observation group(n=23) and the control group(n=22). The patients in the control group only underwent vertebral posterior screw rod fixation. Patients in the observation group underwent transpedicular bone grafting based on that applied on patients in the control group, vertebral injury segment Cobb angle, incidence of fixed complications, visual analogue scale(VAS), Chinese version of oswestry disability index(CODI) evaluation, fracture healing state and the height of vertebral body compression rate were compared between the two groups three months after the operation.Results　Vertebral injury segment Cobb angle, vertebral body height compression ratio, visual analogue scale(VAS) and CODI evaluation in the observation group were significantly lower than those of patients in the control group three months after the operation(P<0.05); The fracture healing rate of the patients in the observation group(82.60%) was significantly higher than that of the patients in the control group(54.55%)(P<0.05). The incidence of internal fixation complication was 8.70% in the observation group, and 9.10% in the control group(P>0.05).Conclusion　Vertebral arch bone grounding is a safe and effective method for the treatment of thoracolumbar spine burst fracture.]]> 2017/9/1 11:34:47 PENG Zhi-hao 246true ［Abstract］　Objective　To explore the effects of entecavir on the antiviral treatment for HBV-DNA positive primary hepatocellular carcinoma(HCC).Methods　60 patients with HBV-DNA positive HCC after radical operation were randomly divided into the observation group（n=35） and the control group（n=25）. Both of the two groups received the conventional anti-inflammatory therapy and liver-protecting treatment. Besides, entecavir was given to the observation group as an anti-HBV therapy 0.5 mg per day for more than 48 weeks 1 to 2 weeks after the radical operation. The liver function, HBV-DNA ration, AFP and disease-free survival rate of the patients were compared between the two groups.Results　（1）HBV-DNA loads and AFP level declined in the observation group significantly than those did in the control group after 3 and 6 months′ treatment(P<0.01); （2）The levels of ALT, AST, ALP, GGT in the observation group declined after 1 and 6 month′s treatment. There were no significant changes of the levels of ALT, AST, ALP, GGT in the control groups after 1 month′s treatment. On the contrary, the levels of the above indicators increased after 6 months′ treatment in the control groups. There were significant differences on the levels of the indicators between the two groups(P<0.01); （3）Followed up for 3 years, 19 cases died, in which 13 cases were in the control group and 6 cases in the observation group, with a significantl difference in disease-free survival rate between the two groups(P<0.01).Conclusion　Entecavir Antiviral treatment with entecavir can reduce the viral load, improve liver function after radical operation, reduce the recurrence rate and prolong the survival time.]]> 2017/9/1 11:34:47 LIN Qing, LI Min-jie, LI Hai-qiang, et al. 245true ［Abstract］　Objective　To observe the effectiveness and safety of noninvasive mechanical ventilation in the treatment of severe respiratory failure in elderly patients.Methods　Ninety patients with severe respiratory failure treated with mechanical ventilation were divided into the study group and the control group according to the different mechanical ventilation schemes. The study group was conducted with noninvasive sequential mechanical ventilation, while the control group received invasive mechanical ventilation. The blood gas, the clinical effect and the degree of stress reaction were compared between the two groups.Results　The success rate of ventilator weaning, ventilator-associated pneumonia, reintubation rate and mortality rate were significantly lower in the study group than those in the control group, with significant differences between the two groups(P<0.05); The heart rate, respiration, pH, PaO₂, PaCO₂, SaO₂ in the study group improved significantly better than those in the control group(P<0.05); There were significant differences in adrenaline(E), norepinephrine(NE), renin(R), angiotensin(AT) and angiotensin-Ⅱ levels between the study group and the control group(P<0.05). The total mechanical ventilation time, the hospitalization time, the duration of ventilation, the length of stay in ICU, the sternum sign disappeared time, and the time of PaO₂/FiO₂ were shorter in the study group than in the control group(P<0.05); The average hospitalization cost of the study group was significantly less than that of the control group(P<0.05).Conclusion　Noninvasive sequential mechanical ventilation has a better clinical effect and a lower mortality rate in the treatment of severe respiratory failure.]]> 2017/9/1 11:34:47 LI Hong-jian 244true ［Abstract］　Objective　To explore the clinical situation of general pediatric inpatients in Guigang Maternal and Child Health-Care Hospital, and provide a scientific basis for the treatment and prevention of childhood diseases in the region.Methods　The electronic medical records of 7 981 discharged pediatric inpatients from January 2012 to December 2014 were analyzed retrospectively.Results　The male children were more than female children; The largest number of children was at the age of 0～12 months, accounting for 69.30% in all cases. The most common five diseases in order were pneumonia, acute bronchitis, infantile enteritis, Pharynx tonsillitis and Mediterranean anemia. The average time of hospitalization was 4.01 days in which 84.28% of the children were hospitalized for less than 7 days. 2 772 cases were hospitalized in summer(34.73%), 2 103 cases in the spring(26.35%), 1 604 cases in the winter(20.10%) and 1 502 cases in the autumn(18.82%). The constituent ratios of hospital discharge in order were in April, in May, and in June. The cure rate was 91.20%, and the mortality rate was 0.03%.Conclusion　Male children are more than female children in paediatric inpatients; The majority of paediatric inpatients are less than 1 year old; Infectious diseases of respiratory and digestive systems are common in paediatric inpatiants; The hospitalization time for paediatric inpatiants is short; More paediatric inpatients are hospitalized in the summer than in autumn.]]> 2017/9/1 11:34:47 DUAN Jie-hua, YU Dong-lin, ZHANG Jun-hua, et al. 243true ［Abstract］　Objective　To investigate the effects of dexmedetomidine on postoperative cognitive dyfunction and the brain metabolism in elderly patients with orthopedics operation.Methods　80 ASA physical status Ⅱ or Ⅲ patients, aged 65～93 years, were divided into two groups by the double blind method. The observation group was given dexmedetomidine during the operation(n=40) and the control group was given 0.9% sodium chloride solution(n=40). Blood sample of 1 ml was taken from the radial artery and jugular bulb respectively before administration(T₀), when withdrawing drugs(T₁) and after the surgery(T₂) for gas analysis, oxygen saturation(SjvO₂) and calculation of the cerebral arteries-venous oxygen content difference(Da-jvO₂) and cerebral oxygen uptake rate(CERO₂). Brief mental state examination(MMSE) was scored in each group before and 1, 3 days after the operation.Results　Da-jvO₂ and CERO₂ were decreased in the observation group at T₁ and T₂ compared with those before the operation and at each point of the control group(P<0.01). Postoperative cognitive decline occurred in 10 patients(12.5%), including 2 cases in the observation group and 8 cases in the control group(χ²=5.16, P<0.05).Conclusion　Dexmedetomidine can effectively improve sedation, anesthesia quality, reduce brain metabolism in elderly patients during orthopedic surgery, and thus effectively prevents the occurrence of postoperative POCD.]]> 2017/9/6 16:16:49 QIN Xing-long, HUANG Chun-liu 242true ［Abstract］　Objective　To study the effect of isoglycyrrhizinate magnesium combined with reduced glutathione on drug-induced liver injury in elderly patients.Methods　Sixty-six elderly patients with drug-induced liver injury were randomly divided into two groups, with 33 cases in each group. The control group was given isoglycyrrhizinate magnesium 100 mg and the treatment group was given isoglycyrrhizinate magnesium 100 mg+reduced glutathione 1.2 g, 5%GS 100 ml(or 0.9%NS 100 ml) for intravenous drip, qd×15 days. Alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), γ- glutamyl transferase(GGT) and alkaline phosphatase(ALP) were detected.Results　The treatment group was more effective in restoring liver function than the control group(P<0.05).Conclusion　Isoglycyrrhizinate magnesium combined with reduced glutathione is effective in the treatment of drug-induced liver injury in elderly patients.]]> 2017/9/6 16:16:49 ZHOU Xiao-ping, ZHOU Xin-ming 241true ［Abstract］　Objective　To analyze the clinical characteristics of drug-induced liver injury(DILI) and to deepen the understanding and recognition of DILI.Methods　A total of 98 patients with DILI were collected consecutively. The prognosis was analyzed after withdrawing known or suspected drugs according to the patients′ history of taking medicine, clinical situation, liver function, serum hepatitis virus markers and B ultrasound.Results　In these patients, DILI had no significant differences in gender. The patients over 40 years old were more common, accounting for 75.51%; The mainly responsible drugs are Chinese traditional medicine(41.84%), antipyretic analgesic anti-inflammatory drugs(14.29%) and antibiotics(11.22%). Liver function tests showed elevated transaminase, with high level of ALT(92.86%), of which 59.18% was more than 500 U/L; Elevated bilirubin accounted for 85.71%, of which 64.29% was direct bilirubin; The lasting time of drug-induced liver injury varied with different types of drugs. The fastest one occurred 5 days after the treatment and the slowest one occurred 10 months after the treatment, with an average being 3 months. The prognosis of drug-induced liver injury was good, without dead cases.Conclusion　Clinical features of drug-induced liver injury are not specific, with hepatic cell injury and cholestasis in bile as the main manifestations. It is important to inquire the history of using drugs in detail and withdraw the related medication timely. The prognosis of drug-induced liver injury is good.]]> 2017/9/6 16:16:49 LIAO Shu-lan, LIANG Lie-xin 240true ［Abstract］　Objective　To evaluate the cerebral perfusion resulting from different degrees of stenosis carotid artery by CT perfusion（CTP） imaging and to provide the basis for clinical diagnosis and treatment of carotid artery stenosis cerebral ischemia.Methods　Forty-eight patients with unilateral carotid artery stenosis from June 2010 to June 2012 were selected. The cerebral perfusion states of different parts of the brain in the patients with different degrees of stenosis carotid artery were observed.Results　rCBF, rCBV of different anatomic sites of the brain tissues in patients with different narrow degrees of unilateral internal carotid artery were not significantly different. The revised trauma scores(rTS) of cerebral temporal leaf, basal ganglia, anterior watershed gray matter, anterior watershed white matter,after watershed gray matter, after watershed white matter of occlusion patients were longer than those of moderate stenosis patients(P<0.05); the rTS of anterior watershed gray matter, anterior watershed white matter, after watershed white matter of occlusion patients were longer than those of severe stenosis patients(P<0.05); the rTTP of cerebral temporal leaf, basal ganglia, anterior watershed white matter, after watershed gray matter of occlusion patients were longer than those of moderate stenosis patients(P<0.05); the rTTP of basal ganglia, anterior watershed gray matter, anterior watershed white matter of occlusion patients were longer than those of moderate stenosis patients(P<0.05).Conclusion　The cerebral perfusion states of patients with carotid artery stenosis can be effectively evaluated by CTP. With the increasing degrees of the carotid stenosis, the perfusion abnormalities increase significantly, especially in anterior watershed and after watershed, and in white matter after watershed.]]> 2017/9/6 16:16:49 LU Meng-lian 239true ［Abstract］　Objective　To explore the levels and signigicance of serum high-sensitivity C-reactive protein(hs-CRP) in asthmatic patients during acute attack.Methods　Eighty-five patients with asthma during acute attack period in our department were taken as the acute group and other 48 patients with asthma during remission period as the remission group, and 46 healthy people were taken as the control group. The serum hs-CRP and pulmonary function index were determined in the three groups.Results　There hs-CRP, FEV1% and FEV1/FVC% among the three groups were significant differences(P<0.05). The levels of hs-CRP in the acute group and the remission group were signigicantly higher than that in the control group, and the FEV1% and FEV1/FVC% were signigicantly lower than those in the control group(P<0.05). The level of hs-CRP of the acute group was signigicantly higher than that of the remission group, and the FEV1% and FEV1/FVC% in the acute group were signigicant lower than those in the remission group(P<0.05). With the increase of asthma severity, the level of hs-CRP increased(P<0.05). The level of serum hs-CRP was negatively associated with FEV1% and FEV1/FVC% in the acute group(P<0.05), but the level of serum hs-CRP was not associated with FEV1% and FEV1/FVC% in the remission group(P>0.05).Conclusion　The level of serum hs-CRP is signigicantly increased in asthmatic patients during acute attack, and the level of serum hs-CRP is associated with pulmonary function index in asthmatic patients during acute attack.]]> 2017/9/6 16:16:49 MO Yan-ping 238true ［Abstract］　Objective　To observe the clinical effect of lighted stylet tracheal intubation on old patients with general anesthesia and laparoscopic cholecystectomy.Methods　Sixty old patients were enrolled and randomly divided into the lighted stylet group(Group A) and the direct laryngoscopy group(Group B). The patients in Group A were intubated with the lighted stylet device, and the patients in Group B were intubated with the direct laryngoscopy after the induction of general anesthesia. Heart rate(HR), mean arterial blood pressure(MAP) and SpO₂ were measured immediately before induction（T0）, after induction but before intubation（T1）, intubating（T2）, after intubation for 1 min（T3）, after intubation for 5 min, respectively. The above indexes and the complications after intubation, including oral mucosa injury, tooth and gingival injury, throat pain and hoarseness were compared between the two groups.Results　MAP and HR at T2 and T3 were significantly higher than those before intubation in both of the two groups; MAP and HR at T2 and T3 were significantly higher in Group B than in Group A; The intubation time and the complications in Group A were significantly lower than those in Group B.Conclusion　Tracheal intubation with lighted stylet inhibits more effectively stress reaction than with direct laparoscopy in old patients, keeping their hemodynamics stable, improving safety and comfortability during anesthesia induction and intubation.]]> 2017/7/4 9:03:44 WANG Long-ping, LIU Ying, FANG Ming, et al 237true ［Abstract］　Objective　To study the clinical application value of narrow-band imaging magnifying endoscopy(NBI-ME) in the diagnosis of gastric mucosal intraepithelial neoplasia.Methods　One hundred patients with focal lesions examined by white light endoscopy(WLE) were selected in this study, and NIB-ME check was used to observe the pathological changes of gastric mucosa and capillaries, and then the morphologies of gastric mucosa and capillaries were observed respectively on the basis of Sakami classification criteria and Yao. The biopsy of the lesions was performed and the results were compared with the pathological results.Results　In 100 focal lesions examined by endoscopy inflammation was histopathologically,confirmed in 31 cases(31.0%), low level intraepithelial neoplasia in 44 cases(44.0%), and high level intraepithelial neoplasia in 25 cases(25.0%), and 18 cases with early gastric cancer(18.0%). The sensitivity, specificity, positive predictive value, negative predictive value and coincidence rate of in diagnosing intraepithelial neoplasia were 58.7%, 35.3%, 62.7%, 29.3% and 49.0% respectively; The sensitivity,specificity intraepithelial neoplasia, and positive predictive value, negative predictive value and coincidence rate of NBI - ME in diagnosing intraepithelial neoplasia were 84.4%, 43.5%, 83.3%, 45.5% and 75.0% respectively. The accuracy of NBI-ME in diagnosing the early gastric cancer was significantly higher than that of WLE(75.0% vs 49.0%, P<0.05).Conclusion　Magnifying endoscopy with narrow-band imaging has a high clinical application value in the diagnosis of gastric mucosal intraepithelial neoplasia.]]> 2017/7/4 9:03:44 ZENG Hai-long, ZHANG Zheng-kun, TIAN Jun-cai, et al 236true ［Abstract］　Objective　To evaluate the clinical value of tamoxifen citrate in the treatment of idiopathic oligoasthenospermia.Methods　The clinical data of 276 patients with the idiopathic oligoasthenospermia from January 2012 to December 2014 were retrospectively analyzed. All of these 276 patients were divided into two groups according to the different treatment methods. The treatment group(n=148) was treated with the triple therapy of tamoxifen citrate along with vitamin E and ATP, and the control group(n=128) was treated with the usual therapy of vitamin E and ATP only. The parameters of sperms were compared between the two groups 3 months after the treatment.Results　After the treatment, the total number of sperm and the forward movement percentage of sperms were significantly elevated than those before the treatment in the two groups. There were no significant differences between the two groups before the treatment(P>0.05). However, the total number of sperms in the treatment group was significantly less than that in the control group（P<0.01）, and the forward movement percentage of sperms in the treatment group was elevated than that in the control group（P<0.01）.Conclusion　Tamoxifen citrate can improve the parameters of sperms in patients with idiopathic oligoasthenospermia, but can′t significantly increase the total number of sperms, which needs further study to evaluate its clinical application.]]> 2017/7/4 9:03:44 LI Gang, CHEN Wei-bin, LIU Huang 235true ［Abstract］　Objective　To compare the curative effects between transbronchoscopic balloon detection(TBD) plus selective bronchus occlusion(SBO) and thrombin pleural adhesions(TPA) in the treatment of intractable pneumothorax.Methods　Seventy-one partents in our department who received needle thoracocetesis and chest tube drainage for 7～14 days but failed to close the spontaneous pneumothorax were collected and were treated with TBD plus SBO(TBD+SBO group, n=26) or thrombin pleural adhesions(TPA group, n=45) in the treatment of intractable pneumothorax. The curative effects and adverse reactions were compared between the two groups.Results　The successful rate was 69.2%(18/26) in TBD+SBO group, and 48.9%(22/45) in TPA group. The effective rate of TBD+SBO group was 84.6%(22/26), and the effective rate of TPA group was 71.1%(32/45). The curative effect of TBD+SBO group was better than that of the TPA group(P<0.05).Conclusion　Both TPA and TBD plus SBO are safe and effective in the treatment of intractable pneumothorax particularly for the patients with poor conditions, or for those with decreased lung function and for those who are reluctant to accept the surgery.]]> 2017/7/4 9:03:44 WANG Zhi-yong, ZHENG Xun-bo, CHEN Zhi-bing, et al 234true ［Abstract］　Objective　To observe the clinical effect of kirsohmer wire in combination with mini bone anchor screw on the treatment of chronic mallet finger deformity.Methods　Fifty patients with chronic mallet finger deformity admitted to the hospital from January 2013 to July 2015 were divided into two groups according to the different therapeutic methods. The control group（n=24） underwent the suture therapy of pure simple internal fixation tendon attachment of kirsohmer wire, and the observation group（n=26） underwent the therapy of kirsohmer wire in combination with mini anchor screw. The hospital stay, operation duration, treatment cost and complications were compared between the two groups.Results　The complication rate of the observation group（7.69%） was signficantly less than that of the control group（25.00%）, P<0.05. The operation duration and hospital stay of the observation group were significantly shorter than those of the control group, P<0.05. The clinical effect of the observation group was better than that of the control group（70.83%）, P<0.05.Conclusion　Kirsohmer wire in combination with mini bone anchor screw is safe and effective in the treatment of chronic mallet finger deformity.]]> 2017/7/10 17:13:59 YE Song-lin, CHEN Li, QIN Xiao-feng, et al. 233true ［Abstract］　Objective　To study the anesthetic effects of two types of drug delievery of dexmedetomidine on gynecologic laparoscopic surgery.Methods　One hundred patients on whom hysteromyomectomy was performd in our hospital from December 2013 to December 2014 were divided into group A and group B, with 50 cases in each group. Group A received single intravenous injection of dexmedetomidine orders intravenous injection, group B received continuous intravenous injection of dexmedetomidine. The extubation time,the time for staying in postanesthetic care unit, the recovery time of orientation and adverse reactions were compared between the two groups.Results　The extubation time, the time for staying in postanesthetic care unit and the recovery time of orientation in group A were significantly shorter than those in group B(P<0.05). There were no significant diffirerences in the mean arterial pressure and heart rate between the two groups(P>0.05). The mean arterial pressure and heart rate of group A were significantly less than those of group B at the time points of 5, 10, 20 and 40 min after establishing the pneumoperitoneum(P>0.05). The incidence of adverse events in group A was significantly lower than that in group B(P<0.05).Conclusion　A single intravenous injection of dexmedetomidine is safe and effective for anesthesia in gynecologic laparoscopic surgery.]]> 2017/7/10 17:13:59 SONG Guan-zhong, ZHU Xiao-mei, AN Xiao-jie 232true ［Abstract］　Objective　To evaluate the clinical value of uterine artery embolization in the treatment of intractable postpartum hemorrhage.Methods　Thirty-six cases with intractable postpartum hemorrhage were collected as the observation group, and the bilateral uterine artery embolization with gelatin sponge particles was performed on them on the basis of the routine treatment. Other 35 matched cases were collected as the control group and received the conventional treatment, including massage of the uterus, injection of drugs for uterine contraction and intra-uterine pack with sterilized gauze or modified B-Lynch suture. Hysterectomy was performed on those whose treatments had failed. The hemostatic effect, consumption of blood and the postoperative complications were compared between the two groups.Results　The immediately stopped bleeding by arterial embolization was 100% in the observation group and 62.86% in the control group,with a significant difference between the two groups(χ²=16.368, P=0.000); The consumption of blood in the observation group was significantly less than that in the control group［(1200±180)ml vs (1597±182)ml］, (t=9.241, P=0.000).Conclusion　Uterine artery embolization is effective in the treatment of intractable postpartum hemorrhage, with the advantages of rapid hemostasis, small trauma and less complications.]]> 2017/7/10 17:13:59 YANG Qing-xue, ZHOU Mei-ling 231true ［Abstract］　Objective　To study the clinical effects of axillary thoracotomy and posterolateral approaches through incision lobectomia pulmonalis on the treatment of early peripheral lung cancer.Methods　The baseline survey was conducted in 84 patients with early peripheral lung cancer in our hospital from August 2013 to August 2015 by prospective cohort study. The patients were divided into two groups by the random lot method with 42 cases in each group. Group A underwent axillary thoracotomy lobectomia pulmonalis, and group B received posterolateral approaches through incision lobectomia pulmonalis. The length of the operative incision, intraoperative blood loss, total operation time, postoperative drainage volume, indwelling time of drainage tube, hospital stay and the other perioperative indicators, the postoperative pain score, dosage of morphine and complications occurrence were compared between the two groups.Results　The length of the operative incision, the intraoperative blood loss, the indwelling time of drainage tube and the hospital stay in group A were significantly shorter or less than those in group B［(7.69±1.63)cm vs (22.14±3.87)cm, (182.74±74.53)ml vs (229.34±80.45)ml, (6.25±1.49)d vs (7.62±1.48)d, (11.37±1.86)d vs (13.21±2.42)d］(P<0.05). The postoperative pain scores and dosage of morphine in group A were significantly lower than those in group B［(4.43±1.26) vs (7.02±1.06), (187.82±67.82)mg vs (257.36±77.34)mg］(P<0.05). The incidence of postoperative complications in group A was significantly lower than that in group B(19.05% vs 40.48%)(P<0.05).Conclusion　Axillary thoracotomy lobectomia pulmonalis and posterolateral approaches through incision both have significant therapeutic effects on the treatment of early peripheral lung cancer, in which axillary thoracotomy lobectomia pulmonalis causes less damages to the patients′ body, quickens their recovery and reduces the incidence of postoperative complications.]]> 2017/7/10 17:13:59 LIU Peng-tao, LI He-peng, XU Hai-wei, et al. 230true ［Abstract］　Objective　To investigate the effects of high-flux hemodialysis on calcium phosphorus metabolism and parathyroid hormone in patients with maintenance hemodialysis(MHD).Methods　Sixty-two patients receiving MHD from February 2013 to December 2014 in our hospital were randomly divided into two groups. The high-flux hemodialysis(HFHD) group(n=32) was treated with high-flux hemodialysis, and the low-flux hemodialysis(LFHG) group(n=30) was treated with conventional hemodialysis. The levels of serum calcium, serum phosphorus and parathyroid hormone were compared between the two groups before and 1, 6 months after hemodialysis.Results　Compared with those before hemodialysis, the levels of serum phosphorus, calcium-phosphorus product and parathyroid hormone in the HFHD group were significantly decreased 1, 6 months after hemodialysis(P<0.05), however there were no significant differences in the above indicators(P>0.05). Compared with the LFHD group, the levels of serum phosphorus, calcium-phosphorus and parathyroid hormone in the HFHD group were significantly decreased 1, 6 months after hemodialysis(P<0.05).Conclusion　High-flux hemodialysis can effectively reduce the levels of serum parathyroid hormone and improve phosphorus metabolism in MHD patients.]]> 2017/7/10 17:15:23 SU Xiao-xia, LI Hong-bo 229true ［Abstract］　Objective　To investigate the drug treatment for elderly patients with arteriosclerosis and diabetes after interventional therapy.Methods　Seventy-eight elderly patients with artery sclerosis complicated with diabetes mellitus from December 2010 to December 2013 were collected as the research subjects. After the interventional therapy, the patients were divided into the control group(treated with clopidogrel treatment) and the study group(postoperative administration of clopidogrel combined with cilostazol treatment) according to the different treatment methods, with 39 cases in each group. The success rate, limb salvage rate, symptom relief rate, adverse reactions and ABI value were compared between the two groups 1 year after the treatment.Results　(1)The success rate of the interventional therapy was 100%, and the rate of the limb salvage was 97.44% in the study group 1 year after the treatment. (2)The amputation rate, intermittent lameness rate and resting pain rate in the study group were significantly lower than those in the control group 1 year after the treatment(P<0.05). (3)There was no significant difference in ABI value between the two groups before the treatment. ABI values were improved in both of the two groups 1 year after the treatment, however ABI value of the research group was significantly higher than that of the control group(P<0.05).Conclusion　Interventional therapy is effective for elderly patients with arteriosclerosis and diabetes. Clopidogrel in combination with cilostazol is safe and effective in the treatment of senile arteriosclerosis complicated with diabetes mellitus.]]> 2017/7/10 17:15:23 GUO Tong 228true ［Abstract］　Objective　To study the curative effects of laparoscopic transabdominal preperitoneal prosthesis(TAPP) on the treatment of inguinal hernia and postoperative short-term quality of life.Methods　Eighty patients with inguinal hernia treated in our hospital from October 2013 to October 2015 were selected as the study subjects and were divided into two groups by random number table method, with 40 cases in each group. The observation group was treated with laparoscopic TAPP and the control group was treated with open tension-free inguinal herniorrhaphy. The success rate of the operation, postoperative recurrence rate, complications and changes of quality of life in the two groups were observed.Results　The success rate of the operation and the incidence of postoperative complications in the observation group were 100.00% and 10.00% respectively, with a significant difference between the observation group and the control group(P>0.05). The recurrence rate in the observation group(2.50%) was significantly lower than that of the control group(15.00%)(P<0.05). The total scores of postoperative quality of life in the observation group（89.23±5.61） were significantly higher than those in the control group(76.63±4.95)(P<0.01).Conclusion　Laparoscopic TAPP is successful in the treatment of inguinal hernia, with a significant improvement of the quality of life and a low postoperative recurrence.]]> 2017/7/10 17:15:23 REN Tong-liang 227true ［Abstract］　Objective　To investigate the related risk factors of acute lung injury(ALI) in acute stage in patients with severe acute pancreatitis(SAP).Methods　One hundred and fourteen patients with SAP were selected as the research subjects. According to the incidence of ALI in the acute stage, the patients were divided into the injury group(n=36) and the non-injury group(n=78). The clinical data of the patients were retrospectively analyzed. The indexes with significant differences after univariate analysis were analyzed by non-conditional Logistic regression analysis.Results　（1）There were no significant differences in general data such as gender, causes, average length of hospital stay, blood glucose concentration and chronic medical history between the two groups(P>0.05); The age, course of disease and Ranson score of the injury group were significantly higher than those of the non-injury group(P<0.01); Besides, the involved organs ≥2 and the rate of abdominal infection, the rate of mechanical ventilation therapy and the rate of complication with systemic inflammatory response syndrome(SIRS) in the injury group were significantly higher than those in the non-injury group(P<0.01); The rates of APACHEⅡ scores <8 points and smoking history in the injury group were significantly lower than those in the non-injury group(P<0.01).（2）Non conditional Logistic regression equation showed that age, course of disease, complication with SIRS, organs involved, mechanical ventilation therapy, abdominal infection and Ranson score were the independent risk factors for ALI in the acute stage in the patients with SAP(P<0.05), while smoking and APACHEⅡ<8 points were the protective factors(P<0.05).Conclusion　Age, course of disease, organs involved, mechanical ventilation therapy, abdominal infection, Ranson score and complication with SIRS are the independent risk factors for ALI in the acute stage of the patients with SAP.]]> 2017/7/10 17:15:23 ZHANG Xiao-shan 226true ［Abstract］　Objective　To analyze the risk factors of severe hand-foot-mouth disease(HFMD) with heart failure in children and the curative effect of milrinone combined with metoprolol on HFMD.Methods　The clinical data of 98 children with severe HFMD in our hospital from April 2012 to April 2015 were collected, including 15 cases complicated with heart failure and 83 cases without complications. The risk factors of severe HFMD with heart failure were analyzed and the clinical effect of milrinone combined with metoprolol on severe HFMD was observed.Results　Multiple factors analysis showed that the independent risk factors of heart failure in children with severe HFMD were tachypnea, hemodynamic changes of blood pressure and heart rate and EV71 infections(P<0.05). After the treatment, LVEF and CO increased. Compared with those before the treatment, the differences were statistically significant(P<0.05).Conclusion　Tachypnea, hemodynamic changes and EV71 infection are the independent risk factors for heart failure in the children with severe HFMD. Milrinone combined with metoprolol can improve the cardiac function and enhance the body′s immune function in children with severe HFMD.]]> 2017/7/10 17:15:23 WANG Li-jun 225true ［Abstract］　Objective　To explore the clinical effect of tirofiban on the treatment of acute ST segment elevation myocardial infarction(STEMI) before emergency interventional therapy.Methods　One hundred and thirteen patients with STEMI who were admitted to our hospital from June 2012 to June 2015 were selected as the study subjects. According to the random number table method, the patients were divided into the observation group(n=57) and the control group(n=56). The observation group was immediately treated with tirofiban 0.5 mg, intravenous injection after coronary angiography. Then, they were treated with emergency coronary interventional surgery. The control group was treated with emergency PCI after coronary angiography and 0.5 mg tirofiban was injected into the coronary artery after the first-time balloon dilatation. The proportions of the patients with infarct related blood vessel TIMI grade Ⅲ, the incidence of the cardiovascular events and bleeding during hospitalization were compared between the two groups.Results　The proportion of the patients with infarct related blood vessel TIMI grade Ⅲ in the observation group(42.1%) was higher than that in the control group(23.2%)(P<0.05); The incidence of bleeding was 5.3% in the observation group and 7.1% in the control group(P>0.05). There were no statistically significant differences in the incidences of re-infarction, cardiogenic shock, heart failure, death and other cardiovascular events between the two groups during the hospitalization(P>0.05).Conclusion　The application of tirofiban before emergency interventional therapy for the patients with STEMI makes preoperative blood quickly flow to a certain extent and makes the proportions of patients with infarct related blood vessel TIMI grade Ⅲ higher, but the bleeding events and cardiovascular events are not increased during the hospitalization.]]> 2017/7/10 17:15:23 SONG Xin-hua 224true ［Abstract］　Objective　To explore the effect of three dimensional conformal radiotherapy combined with a small dose of paclitaxel plus cisplatin(TP) chemotherapy on the quality of life of the patients with esophageal cancer.Methods　64 patients with esophageal cancer in our hospital were selected and randomly divided into the observation group and the control group according to the random number table method, with 32 cases in each group. The control group was treated with three dimensional conformal radiation therapy. The observation group received a small dose of TP chemotherapy based on the same treatment with which the control group was treated. The quality of life was compared between the two groups before and after the treatment.Results　There was no significant difference in quality of life between the two groups before the treatment(P>0.05). After the treatment, the scores of physical pain, physiological function and social function in the observation group were significantly higher than those in the control group(P<0.01).Conclusion　Three dimensional conformal radiotherapy combined with a small dose of TP chemotherapy has a significant effect on the treatment of esophageal cancer. It can effectively improve the quality of life for the patients and has a high value in the clinical application.]]> 2017/9/26 8:05:56 FENG Shu-juan 223true ［Abstract］　Objective　To investigate the effect of tirofiban platelet aggregation and inflammatory markers in the elderly patients with non-ST segment elevation acute coronary syndrome（NSTE-ACS）.Methods　86 NSTE-ACS patients admitted to our hospital from April 2013 to April 2015 were randomly divided into the observation group and the control group, with 43 cases in each group. Both of the two groups were given the routine treatment of aspirin, clopidogrel and enoxaparin, besides this treatment the observation group was treated with tirofiban for 1 week. The platelet aggregation and inflammatory markers, the clinical effect and prognosis were compared between the two groups.Results　The inflammatory markers of the observation group were significantly lower than those of the control group(P<0.01). The clinical efficiency of the observation group was significantly higher than that of the control group(P<0.05); The platelet aggregation rate and the incidence of cardiovascular events in the observation group were significantly lower than those in the control group(P<0.05). Conclusion　Tirofiban can effectively reduce the myocardial injury, the rate of platelet aggregation and the concentration of inflammatory markers, and improve the clinical prognosis for the elderly patients with NSTE-ACS.]]> 2017/9/26 8:05:56 WANG Zong-shuai 222true ［Abstract］　Objective　To explore the effects of beclomethasone dipropionate combined with montelukast sodium on cough variant asthma airway inflammation in children.Methods　90 children with cough variant asthma were selected from February 2015 to April 2016, and all the children were divided into two groups by random digits table. The control group(n=45) was given the treatment of beclometasone dipropionate aerosol, and the observation group(n=45) received montelukast treatment based on the same treatment that was given to the control group for 12 consecutive weeks. The levels of airway inflammation and pulmonary function were compared between the two groups before and after the treatment.Results　Before the treatment, there were no significant differences in the levels of airway inflammation between the two groups(P>0.05). After the treatment, the levels of IL-10, IL-8, IL-5 and EOS in the observation group were significantly lower than those in the control group(P<0.01). There were no significant differences in the levels of MMEF and FEV₁ between the two groups before the treatment(P>0.05). After the treatment, the levels of MMEF and FEV₁ in the observation group were significantly higher than those in the control group(P<0.01).Conclusion　Beclomethasone dipropionate combined with montelukast sodium can effectively improve the levels of airway inflammation and reduce the inflammation in the treatment of cough variant asthma in children.]]> 2017/9/26 8:05:56 HAO Xin-zheng 221true ［Abstract］　Objective　To explore the the effect of propofol and sevoflurane anesthesia on agitation and cognitive function of elderly patients during the period of postoperative revival.Methods　86 elderly patients undergoing the selective operation from December 2014 to May 2016 were randomly divided into the propofol group and the sevoflurane group. The agitation and cognitive function of the patients during the period of postoperative revival were compared between the two groups.Results　The time of spontaneous breath, eys opening, extubation and response in the sevoflurane group was signigicantly longer than that in the propofol group(P<0.01). The agitation scores of five and 15 minutes after extubation in the sevoflurane group were signigicantly higher than those in the propofol group(P<0.01). The MMSE scores of 1 h, 4 h, 8 h after the operation in the sevoflurane group were signigicantly lower than those in the propofol group(P<0.05).Conclusion　The agitation scores of propofol are signigicantly excellent than those of sevoflurane for the old patients during the period of postoperative revival, and the influence of propofol on the cognitive function is less.]]> 2017/9/26 8:05:56 NONG Wei-min, LI Chuan-you 220true ［Abstract］　Objective　To explore the effects of parecoxib sodium combined with dezocine preemptive analgesia on cognitive function and inflammatory factors in elderly patients with gastric cancer after operation.Methods　72 elderly patients with gastric cancer treated with operation in our hospital from March 2012 to May 2014 were selected as the research subjects and were divided into the observation group and the control group according to the parity method, with 36 cases in each group. The control group was treated with general anesthesia,and the observation group received parecoxib sodium combined with dezocine intravenous injection. The analgesic effects at different time points, the levels of inflammatory factors, the cognitive function and the occurrence of adverse reactions were observed and compared between the two groups.Results　There were significant differences in VAS scores between the two groups at different detection time points between the different treatment groups(P<0.05), and there was an interaction between the detection time points and the different anesthetic methods(F=5.652, P=0.008).There were no significant differences in the levels of IL-6, IL-8 and TNF-α before operation between the two groups(P>0.05), and the levels of IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group after operation(P<0.01). There was no significant difference in preoperative cognitive function between the two groups(P>0.05), but the cognitive function of the observation group was better than that of the control group, and the incidence of cognitive dysfunction in the observation group(25.00%) was significantly lower than that in the control group(47.22%)(P<0.05). There was a statistically significant difference in the total incidence of adverse reactions between the two groups(χ²=6.769, P=0.009), and it was 30.56% in the observation group, with a significantly lower rate than that in the control group.Conclusion　Parecoxib sodium combined with dezocine analgesia can not only significantly reduce the inflammatory response, but also improve the postoperative cognitive function in the elderly patients with gastric cancer surgery.]]> 2017/8/29 17:08:47 YAN Fa-zhong, TAN Ping, CUI De-zhi, et al. 219true ［Abstract］　Objective　To explore the correlation between the levels of thyroid hormone and prognosis in intensive care unit(ICU) patients with severe infections.Methods　A total of 65 ICU patients with severe infections from January 2015 to June 2016 in our hospital were selected as the infection group and they were divided into the survival subgroup(n=38), and the death subgroup(n=27) according to the survival within twenty-eight days. The other 60 matched patients without infections were selected as the non-infected group. The serum levels of thyroid hormone and APACHE Ⅱ scores were compared among the groups,and the correlation between the levels of thyroid hormone and APACHE Ⅱ scores and the prognosis was ananalyzed.Results　The levels of T₃, T₄, FT₃ and FT₄ in the infection group were significantly lower than those in the non-infected group（P<0.05）. The APACHE Ⅱ scores of the infection group were significantly higher than those of the non-infected group（P<0.05）, however there were no signigicant differences in the levels of TSH between the two groups(P>0.05). The levels of T₃, T₄, FT₃ and FT₄ in the survival subgroup were significantly lower than those in the death subgroup（P<0.05）, but the APACHE Ⅱ scores of the survival subgroup were significantly higher than those of the death subgroup（P<0.05）. There were no significant differences in the levels of TSH between the two subgroups(P>0.05). The levels of T₃, T₄, FT₃ and FT₄ were negatively correlated with the APACHE Ⅱ scores（P<0.05）.Conclusion　The serum levels of thyroid hormone decline in the ICU patients with severe infections, and are negatively correlated with the APACHE Ⅱ scores（P<0.05）.]]> 2017/8/29 17:08:47 LIAO Yu-chi, HE Li-rong 218true ［Abstract］　Objective　To explore the clinical curative effect of montelukast sodium combined with azithromycin on the treatment of mycoplasma pneumonia in children.Methods　46 children with mycoplasma pneumonia were randomly divided into the research group and the control group, the control group received azithromycin treatment alone, and the research group was treated with montelukast sodium plus azithromycin. Both of the two groups maintained 2～3 course of treatment. The drug effects were evaluated according to the symptom signs and laboratory indexes.Results　In the research group, 6 cases were cured, 11 cases markedly improved, 5 cases effective and 1 case ineffective. In the control group, 3 cases were cured, 7 cases markedly improved, 7 cases effective and 6 cases ineffective. The clinical effect of the research group was better than that of the control group（P<0.05). The disappearance time of clinical symptoms and signs in the research group was significantly shorter than that in the control group. The average hospital stay was significantly shorter in the research group than that in the control group. There was no significant difference in C-reactive protein(CRP) between the two groups before the treatment. The levels of CRP after the treatment were significantly lower than those before the treatment in both of the two groups(P<0.05). The complication rate of the research group was significantly lower than that of the control group(8.70% vs 34.78%)(P<0.05).Conclusion　Montelukast sodium combined with azithromycin therapy can improve the curative effect for the children with mycoplasma pneumonia.]]> 2017/8/29 17:08:47 FAN Tong-lian, XIA Yan-hua 217true ［Abstract］　Objective　To detect the levels of carotid intima-media thickness(CAIMT), serum homocysteine(HCY), malondialdehyde(MDA) and superoxide dismutase(SOD) activity and to investigate the correlation between carotid atherosclerosis(CAS) and serum HCY and oxidative stress in the patients with essential hypertension(EH).Methods　CAIMT(Color Doppler), serum HCY(circulating enzymatic), MDA(TBA) and SOD activity(colorimetry) were measured in 266 EH patients. Other 50 healthy people were taken as the control group. The data were compared between the two groups according to the detecting results.Results　(1)The CAS incidence in the EH patients was 62.8%(167/266), associating with age, disease and related course, but not related to genders.(2)The levels of serum HCY and MDA were significantly higher and the activity of SOD was significatly decreased in the patients with EH complicatecl with CAS than those in the healthy controls（t=7.118, 6.326, P<0.05）.(3)The level of serum HCY was positively correlated with the level of MDA（r=0.493, P<0.05）, and negatively correlated with the SOD activity（r=-0.562, P<0.05）.Conclusion　The patients with EH and CAS have high levels of HCY, MDA and low SOD activity. Oxidative stress is associated with the levels of serum homocysteine.]]> 2017/8/29 17:08:47 SUN Yi-qiang, YANG Wen-dong 216true ［Abstract］　Objective　To explore the effect of lidocaine surface anesthesia on reducing arterial puncture pain in the patients treated with hemodialysis.Methods　68 patients treated with hemodialysis by artery puncture in our hospital from February 2014 to April 2015 were randomly divided into the routine group(n=34) and the experimental group(n=34). The routine group was given routine artery puncture, and the experimental group was given lidocaine surface anesthesia one hour before the artery puncture. The degree of puncture pain, adequacy blood flow rates, successful rate of one-time puncture and complication rate were compared between the two groups.Results　The degree of puncture pain in the experimental group was significantly reduced compared with those in the routine group(P<0.05). The adequacy blood flow rate and the successful rate of one-time puncture in the experimental group were 85.29% and 94.12% respectively, which were significantly higher than those in the routine group（52.94% and 67.65%）, (P<0.01). There was no significant difference in the complication(including bleeding, hematoma and inflammation) rate between the experimental group and the routine group（8.82% vs 20.59%）(P>0.05).Conclusion　Lidocaine surface anesthesia can reduce the arterial puncture pain and improve the puncture successful rate, with a safe and reliable clinical result.]]> 2017/7/28 17:24:59 TAN Ping, SHI Yi-qiong, XIE Yuan, et al. 215true ［Abstract］　Objective　To investigate the clinical effect of percutaneous catheter-directed thrombolysis therapy on lower extremity deep venous thrombosis.Methods　82 patients with deep venous thrombosis of lower extremities were randomly divided into the observation group(n=41) and the control group(n=41). The observation group was treated with catheter-directed thrombolysis, and the control group was treated with intravenous thrombolytic therapy alone. The clinical effect, the lower limb swelling, the hospitalization time and limb swelling were compared between the two groups.Results　The effect of the observation group was better than the control group(P<0.05); The recovery of lower limb swelling in the observation group was faster than that in the control group. The hospitalization time of the observation group was shorter than that of the control group(P<0.01). After the treatment, the circumferences of diseased extremities were decreased in both of the two groups(P<0.05), however the circumference of the observation group was smaller than that of the control group after the treatment(P<0.01). The recovery rate of limb swelling of the observation group was higher than that of the control group(P<0.01).Conclusion　Percutaneous catheter-directed thrombolysis is effective for the patients with lower extremity deep venous thrombosis.]]> 2017/7/28 17:24:59 ZHANG Jian-wei, HE Feng 214true ［Abstract］　Objective　To compare the clinical effect of laparoscopy and open wedge resection on the treatment of gastrointestinal stromal tumors.Methods　50 patients with gastrointestinal stromal tumors in our hospital from August 2013 to July 2015 were randomly divided into two groups, with 25 cases in each group. The control group was treated with open wedge resection, and the observation group was treated with laparoscopic surgery. The related data, complications and prognosis were compared between the two groups.Results　The results of the operation in the observation group were better than those in the control group(P<0.05). The complication rate of the observation group(8.00%) was significantly lower than that of the control group(32.00%)(P<0.05). There were no significant differences in the recurrence rate and metastasis rate between the two groups(P>0.05).Conclusion　Laparoscopy is more effective and safer than open wedge resection in the treatment of gastrointestinal stromal tumors.]]> 2017/7/28 17:24:59 YU Qiang 213true ［Abstract］　Objective　To study the effect of non-alcoholic fatty liver disease(NAFLD) on entecavir in the treatment of chronic hepatitis B(CHB) and insulin resistance.Methods　From August 2012 to August 2015, a total of 65 patients with NAFLD complicated with CHB in our hospital were collected as the observation group, and during the same period other 58 patients with CHB were taken as the control group. Both of the two groups were given entecavir for 12 months. After the treatment, the recovery rate of alanine aminotransferase, virological response and insulin resistance were compared between the two groups.Results　After the treatment, the levels of ALT in both of the two groups were significantly decreased, and the control group had more reduction（P<0.01）. The recovery rate of ALT in the observation group(52.31%) was lower than that in the control group(72.41%)（P<0.05）. The HBV-DNA copy numbers in the observation group were significantly higher than those in the control group, and the negative conversion rate of HBV-DNA in the observation group was significantly lower than that in the control group（P<0.05）. The FPG, FINS and HOMA-IR were significantly decreased in both of the two groups, and the control group had more reduction（P<0.05 or P<0.01）.Conclusion　NAFLD is a risk factor influencing the effect of entecavir in the treatment of CHB, therefore, symptomatic treatment of fatty liver should be given to the patients in the treatment of hepatitis B.]]> 2017/7/28 17:24:59 JIANG Jin-yan 212true ［Abstract］　Objective　To investigate the clinical effects of mesalazine combined with triple viable probiotics on the treatment of mild to moderate ulcerative colitis.Methods　90 patients with mild to moderate ulcerative colitis who were hospitalized in the First People′s Hospital of Qinzhou City from June 2013 to February 2016 were randomly divided into the study group and the control group, with 45 cases in each group. The study group was treated with mesalazine combined with probiotics, while the control group was treated with mesalazine. All the patients were treated for 8 weeks and the therapeutic effect and the adverse reactions were compared between the two groups.Results　The patients in the study group were markedly effective in 24 cases, effective in 18 cases and ineffective in 3 cases. The control group was markedly effective in 13 cases, effective in 19 cases and ineffective in 13 cases. The clinical effect of the study group was better than that of the control group(P<0.01). There were no significant differences in disease activity index score, colonoscopy integral and clinical symptom scores between the two groups before the treatment(P>0.05）. The scores of disease activity index, colonoscopy integral and clinical symptom were reduced in both of the two groups after the treatment, but those in the study group decreased more obviously than those in the control group after the treatment(P<0.01）. The adverse reaction rate of the study group(4.44 %）was lower than that of the control group(6.67%）, with no significant difference between the two groups(P>0.05).Conclusion　Mesalazine combined with triple viable probiotics can enhance the therapeutic effect for the patients with mild to moderate ulcerative colitis, but can not increase the incidence of adverse drug reactions.]]> 2017/6/28 15:27:54 YANG Wei-feng, BAN Jie-hong, RAO Guan-hua, et al 211true ［Abstract］　Objective　To observe the curative effect of adefovir dipivoxil combined with pegylated interferon α-2a on the treatment of chronic hepatitis B in HBeAg low potency.Methods　The control group(n=84) was treated with adefovir dipivoxil, and the observation group(n=84) was treated with adefovir dipivoxil combined with pegylated interferon alpha-2a. All the patients were treated for 48 weeks and the clinical curative effect and safety were compared between the two groups.Results　In the observation group, the negative rates of HBeAg and serum HBeAg were 78.6% and 59.5%, which were significantly higher than those in the control group（56.0% and 20.2%）(P<0.05). In both of the two groups, HBV-DNA loads was significantly lower after the treatment than that before the treatment(P<0.05), but there were no significant difference between the two groups after the treatment(P>0.05). The HBeAg titer and hepatic tissue HBVcccDNA load were significantly lower in the observation group than those in the control group(P<0.05).Conclusion　Adefovir dipivoxil combined with pegylated interferon α-2a is effective in the treatment of chronic hepatitis B in HBeAg low potency.]]> 2017/6/28 15:27:54 ZHAI Xing-ju 210true ［Abstract］　Objective　To study the clinical effects of mechanical anastomosis and layered anastomosis by hand on esophagus cancer.Methods　The indexes related to the operation and the incidence of complications were compared between the mechanical anastomosis group(by mechanical anastomosis, n=73) and the hand anastomosis group(layered anastomosis by hand, n=65). All the patients were performed the operation of esophagus cancer from February 2010 to March 2016, and their clinical effects were evaluated and compared between the two anastomosis methods.Results　The esophagogastric anastomosis time, total operation time and hospitalization time of the mechanical group were shorer than those of the hand anastomosis group, but the hospitalization expenses was higher than that of the hand anastomosis group(P<0.01）. The incidence of total complications of the mechanical group was lower than that of the hand anastomosis group(P<0.05）.Conclusion　Mechanical anastomosis is simple and shortens the operation time and makes the patients recover rapidly in the operation of esophagus cancer.]]> 2017/6/28 15:27:54 ZHAO Yan-jiang, HUANG Hong-ru, LAN Lang, et al 209true ［Abstract］　Objective　To investigate the clinical effect of alpha lipoic acid combined with mosapride on the treatment of diabetic gastroparesis.Methods　70 diabetic gastroparesis patients in our hospital were randomly divided into the observation group and the control group, with 35 cases in each group. In addition to usual anti-diabetic treatment, the control group was treated with oral mosapride and the observation group was treated with alpha lipoic acid combined with mosapride for 14 days. The clinical effects were compared between the two groups.Results　There were no significant differences in the levels of motilin and gastric emptying rate between the two groups before treatment(P>0.05). After treatment, the levels of motilin were significantly decreased and the gastric emptying rates in both of the two groups were significantly higher than those before treatment. The level of motilin in the observation group was significantly lower than that in the control group, whereas the gastric emptying rate of the observation group was significantly higher than that of the control group(P<0.01). In the observation group, the clinical effect was markedly effective in 20 cases, effective in 13 cases, ineffective in 2 cases. In the control group, the clinical effect was markedly effective in 14 cases, effective in 12 cases, and ineffective in 9 cases. The clinical effect of the observation group was significantly better than that of the control group(P<0.05).Conclusion　Alpha lipoic acid combined with mosapride is effective in the treatment of diabetic gastroparesis, which effectively regulates gastrointestinal hormones, enhances the gastric emptying rate, reduces the level of motilin, and improves the symptoms and the quality of life of the patients.]]> 2017/6/28 15:27:54 LIANG Hui 208true ［Abstract］　Objective　To study the clinical effects of different statins on acute myocardial infarction(AMI) and the follow-up results.Methods　The data of 168 cases with AMI within 2 years were retrospectively analyzed. All the patients received the conventional therapy for AMI. The levels of blood lipid, blood sugar and inflammation factors, and the changes of the cardiovascular function were detected and compared among different groups of the patients who received different statins of atorvastatin, simvastatin and rosuvastatin 6 months after the treatment. The incidences of adverse drug reactions and adverse cardiovascular events were compared among different groups after a follow-up of six months.Results　The levels of TC, TG, LDL-C and hs-CRP were decreased significantly meanwhile the level of HDL-C was increased significantly in the patients who received the different statins before the treatment(P<0.05); There were significantly differences among rosuvastatin,atorvastatin and simvastatin in the effects of decreasing hs-CRP level and increasing HDL-C level(P<0.05); Atorvastatin and rosuvastatin could significantly increase the concentration of FPG in the patients(P<0.05). There was a significant difference in the effects of increasing FPG and HbA1c between rosuvastatin groups compared with those in the other two groups.Three kinds of statins could significantly improve FMD(P<0.05), however there was no significant differences among them（P>0.05）. There was no significant difference in the rate of adverse reactions between atorvastatin(4.23%), simvastatin(5.77%) and rosuvastatin(4.44%). There was no significant difference in the incidence of adverse cardiovascular events between atorvastatin(5.63%), simvastatin(9.62%) and rosuvastatin(6.67%)（P>0.05）.Conclusion　Atorvastatin, simvastatin and rosuvastatin have similar clinical efficacy and safety in the treatment of AMI and they should be used individually in the patients.]]> 2017/6/5 17:27:11 YU Wei-qing, HUANG Wei-guo 207true ［Abstract］　Objective　To investigate the applied value and prognosis of drilling drainage decompression in diagnosing traumatic hernia.Methods　Ninety-eight patients with traumatic hernia in our hospital from October 2013 to October 2015 were randomly divided into the control group and the observation group, with 49 cases in each group. Decompressive craniotomy or drilling drainage decompression was performed on the patients at the bedside in emergency before craniofomy. Glasgow coma scale(GCS) scores and postoperative complications were compared between the two groups before and after the treatment.Results　There were no significant differences in the GCS scores between the two groups before the treatment(P>0.05). After the treatment, the GCS scores of the observation group were significantly higher than those of the control group(P<0.01). The postoperative complication rate of the observation group(6.12%) was significantly lower than that of the control group(P<0.05).Conclusion　Skull drilling drainage decompression is effective in the treatment of traumatic brain hernia. It can effectively reduce the incidence of postoperative complications and improve the prognosis.]]> 2017/6/5 17:27:11 ZHANG Zhong-zu, AI Wei-qing 206true ［Abstract］　Objective　To explore the clinical efficacy and safety of ultrasound ablation combined with dilation and stent implantation in the treatment of lower extremity arterial occlusion.Methods　Sixty-seven patients with total occlusion of the lower extremity from Februory 2012 to February 2015 were divided into observation group(n=42) and control group(n=25). The control group was treated with conventional drug therapy, and the observation group was treated with ultrasound ablation combined with dilation and stent implantation. The curative effect and the occurrence of the end events were observed and compared between the two groups.Results　The patency rate of the observation group(85.7%) was significantly higher than that of the control group（44.0%）, P<0.01. The mortality rate, the amputation rate and the incidence of cardiovascular events in the observation group were significantly lower than those in the control group（2.4% vs 24.0%, 2.4% vs 24.0%, 4.8 % vs 36.0%)(P<0.05). The ankle brachial index of the observation group(0.82±0.11) was significantly higher than that of the control group(0.61±0.12), P<0.01.Conclusion　Ultrasound ablation combined with angioplasty and stent implantation is effective in the treatment of the artery occlusion in lower extremities.It can effectively clear the complete occlusion of the artery, effectively improve the lower limb blood supply, and reduce the incidence of end events, however its long-term clinical effect still need to be further observed.]]> 2017/6/5 17:27:11 ZHAO Zhi-yong 205true ［Abstract］　Objective　To investigate the changes of intercellular adhesion molecule-1（sICAM-1） and transforming growth factor(TGF-β₁) in peripheral blood cells of the patients with prophase stroke after the intervention of hyperbaric oxygen.Methods　The concentrations of sICAM-1 and TGF-β₁ were measured by enzyme-linked immunosorbent assay(ELISA) in 42 patients with acute stroke and in 42 healthy people. Based on the conventional treatment, 21 patients were randomly selected from the 42 patients with acute stroke and were treated with hyperbaric oxygen for a week.Results　The concentrations of sICAM-1 in the stroke patients were significantly higher than those in the healthy people(P<0.01) 1, 2 and 3 days after stroke, while the concentrations of TGF-β₁ in the stroke patients were significantly lower than those in the control group on the first day and the third day of the stroke. Compared with those in the stroke patient with no intervention of hyperbaric oxygen,the concentrations of sICAM-1 in the patients with the intervention of hyperbaric oxygen were significantly reduced(P<0.01) and the concentrations of TGF-β₁ were significantly increased(P<0.01) 3, 7 and 10 days after the intervention of hyperbaric oxygen.Conclusion　The dynamic changes of sICAM-1 and TGF-β₁ reflect the inflammation and immune status in the patient with prophase stroke. sICAM-1 is the risk factor while TGF-β₁ has a protective effect. The intervention of hyperbaric oxygen plays a role of anti-inflammatory and promoting tissue repair.]]> 2017/6/9 8:58:44 TIAN Xian-min, FENG Xiao-kai 204true ［Abstract］　Objective　To explore the relationship between the levels of homocysteine(Hcy), serum uric acid(SUA) and carotid atherosclerotic plaques in patients with lacunar infarcts.Methods　Ninety-three patients with lacunar infarcts in our hospital from November 2012 to October 2015 were collected as the cerebral infarction group, and they were divided into three subgroups according to the results of ultrasound: IMT normal group(n=26), IMT increased group(n=22) and plaque group(n=45). Ninety healthy people having medical examination in the same period were taken as the conthol group. The levels of Hcy, SUA and IMT were compared among the groups, and the relationships between the indexes were analyzed.Results　The serum levels of Hcy and SUA in the cerebral infarction group were significantly higher than those in the control group（P<0.01）. There were significant differences in the serum levels of Hcy, SUA and IMT among the three subgroups（P<0.05）. All the indexes in the IMT increased group and the plaque group were significantly higher than those in the IMT normal group（P<0.05）, each index in the plaque group was significantly higher than that in the IMT increased group（P<0.05）. Pearson correlation test showed that there was a liner relationship between IMT value and the serum levels of Hcy, SUA in the patients with lacunar infarcts.Conclusion　The serum levels of Hcy and SUA are obviously increased in the patients with lacunar infarcts. The carotid atherosclerotic plaques are associated with the high serum levels of Hcy and SUA.]]> 2017/6/9 8:58:44 LI Hai-hua 203true ［Abstract］　Objective　To observe the myocardial protective effect of sevoflurane and propofol anesthesia on the myocardium of elderly patients with coronary heart disease during noncardiac surgery and the adverse events.Methods　Eighty-six elderly patients with coronary heart disease receiving noncardiac surgery in our hospital from January 2015 to January 2016 were selected, and divided into the observation group(n=43) and the control group(n=43) by random number table. The observation group was given the maintenance anesthesia of sevoflurane during the operation, and the control group received the maintenance anesthesia of propofol. The serum levels of interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), cardiac troponin(cTnI) and glycogen phosphorylase BB(GP-BB) were detected to evaluate the myocardial protective effect and adverse events including conventional adverse events and adverse cardiac events and were compared between the two groups.Results　The levels of IL-6, TNF-α, cTnI and GP-BB were significantly increased immediately after the surgery in the two groups than those before the anesthesia(P<0.01). The levels of IL-6, TNF-α, cTnI and GP-BB in the observation group were (204.68±94.20)pg/ml, (0.69±0.11)ng/ml, (0.82±0.19)ng/ml and (5.18±1.32)ng/ml respectively, and the ascending ranges of the observation group were significantly less than those of the control group(P<0.05); The incidence of the conventional adverse events in the observation group(6.98%) was significantly lower than that in the control group(23.26%)(P<0.05). The incidence of adverse cardiac events of the observation group(18.60%) was significantly lower than that of the control group(44.19%)(P<0.05).Conclusion　Sevoflurane has better myocardial protective effect than propofol on the myocardium of the elderly patients with coronary heart disease during noncardiac surgery.]]> 2017/6/9 8:58:44 LIU Xiao-gang 202true ［Abstract］　Objective　To investigate the clinical effects of laparoscopic surgery on acute cholecystitis and immunologic function in elderly patients.Methods　Seventy-two elderly patients with acute cholecystitis were randomly divided into the laparoscopic cholecystectomy（LC） group(n=37) and the open cholecystectomy(OC) group(n=35). The clinical effects and immunologic function were compared between the two groups.Results　The operative incision length, anal exhaust time,ambulation time and total hospital stay of the LC group were signigicantly shorter than those of the OC group, and the neam intraoperative bleeding of the LC group was signigicantly less than that of the OC group（P<0.01）. The ratio of using postoperative analgesics in the LC group was signigicantly lower than that in the OC group（P<0.05）. The levels of CD4⁺,CD8⁺ and CD4⁺/ CD8⁺ of the LC group 1 and 7 days after the operation were signigicantly higher than those of the OC group,and the levels of CRP of the LC group were signigicantly lower than those of the OC group（P<0.05）.Conclusion　Compared with OC, LC has less trauma,slighter pain and quicker recovery of immune function in the treatment of senile acute cholecystitis.]]> 2017/6/9 8:58:44 WU You-xiang, YANG Jun-jie, YAN Bin, et al. 201true ［Abstract］　Objective　To evaluate the safety and efficacy of antiplatelet therapy of single-dose ticagrelor on patients suffering from acute ST segment elevation myocardial infarction(STEMI) undergoing primary percutaneous coronary intervention(PCI).Methods　Eighty patients with STEMI within 12 h undergoing primary PCI from March 2015 to March 2016 were randomly divided into the ticagrelor group(n=40) and the clopidogrel group(n=40) by using the method of random number table. 12 hours after the operation, ticagrelor was replaced with clopidogrel in the ticagrelor group, while clopidogrel was used before and after the operation in the clopidogrel group. The platelet count before and after the operation, arachidonic acid(AA) and adenosine diphosphate(ADP) induced platelet inhibition rate by thrombelastograph in 2 h, 6 h after the operation, the level of TIMI blood flow of IRA and the major adverse cardiovascular events and bleeding events during hospitalization were compared between the two groups.Results　There were no significant differences between the two groups in the baseline data and the features of coronary artery lesions(P>0.05). ADP induced platelet inhibition rates in 2 h and 6 h after the operation in the ticagrelor group were significantly higher than those in the clopidogrel group(P<0.05). TIMI flow less than 3 of the infarction related artery occurred in 4 cases in the ticagrelor group, while in 13 cases in the clopidogrel group, with a significant difference between the two groups(P<0.05). During the hospitalization, the major adverse cardiovascular events occurred in 4 cases in the ticagrelor group(10.0%), and in 5 cases in the clopidogrel group(12.5%)(P>0.05). There was no significant difference in the incidence of bleeding between the ticagrelor group and the clopidogrel group(10.0% vs 7.5%), P>0.05.Conclusion　Antiplatelet therapy of single-dose ticagrelor is effective and safe on the patients suffering from acute STEMI and undergoing primary PCI.]]> 2017/6/14 10:41:48 LIU Guo-lou, PENG Yong, GAO Wen-jun, et al. 200true ［Abstract］　Objective　To investigate the clinical effects of nail bed nail matrix partial resection on ingrown toenails paronychia.Methods　Three hundred and fifty cases with ingrown toenails paronychia in our hospital were randomly divided into three groups: group A was treated with surgical removal of the nails, group B was treated with surgical removal of part of the nails and group C was given the nail bed nail matrix partial resection. The clinical effects were compared among the three groups.Results　The healing time and the hospitalization stay in group C were significantly shorter than those in the other two groups(P<0.01). The number of dressing changes in group C was significantly less than that in group A or group B(P<0.01). The cure rate of group C was significantly higher than that of group A or group B(P<0.01). The rates of pain, infection and reoccurrence in group C were significantly lower than those in the other two groups(P<0.01).Conclusion　Nail bed nail matrix partial resection is clinically efficacious for ingrown toenails paronychia.]]> 2017/6/14 10:41:48 SU Zhuo-hua, ZHANG Li, SU Hui-xian, et al. 199true ［Abstract］　Objective　To study the value and clinical significance of color Doppler ultrasound in the diagnosis of congenital vertebral artery variation.Methods　One hundred and fifty patients with suspected vertebral artery variation in the hospital from January 2011 to December 2015 were selected as the research subjects. All the patients underwent color Doppler ultrasonography in vertebral artery, and their diagnostic results of CT angiography(CTA) were used as the gold standard. The diagnostic sensitivity, specificity, accuracy, positive predictive value and negative predictive value of color Doppler ultrasound in the diagnosis of vertebral artery were calculated, and the diagnosis rates of the color Doppler ultrasound in the congenital hypoplastic vertebral artery, abnormal position of vertebral artery origin and unilateral double branch vertebral artery were calculated.Results　Of the 150 patients with suspected vertebral artery variation, 131 cases were diagnosed with vertebral artery variation by CTA. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value in the diagnosis of vertebral artery variation were 97.71%, 89.47%, 96.67%, 98.46% and 85.00% respectively. The diagnosis rates of color Doppler ultrasound in the congenital hypoplastic vertebral artery, abnormal position of vertebral artery origin and unilateral double branch vertebral artery were 96.72%, 100.00% and 100.00% respectively.Conclusion　Color Doppler ultrasound has a significant application value in the diagnosis of congenital variation of the vertebral artery.]]> 2017/6/14 10:41:48 ZENG Rong-fang 198true ［Abstract］　Objective　To explore the behavioral and psychiatric symptoms of Alzheimer′s disease and vascular dementia, and to provide the reference for the differential diagnosis of the two diseases.Methods　In the department of neurology of our hospital from January 2013 to February 2016, 49 cases of AD patients(AD group) and 55 cases of VD patients(VD group) were collected. MMSE scores, BEHAVE-AD scores WHO-UCLA AVLT scores were evaluated and compared between the two groups.Results　The aggressive behavior and behavioral disorder rate in the AD group were significantly higher than those in the VD group(P<0.05), and the incidence of affective disorder of the AD group was significantly lower than that of VD group(P<0.05). In terms of MMSE scores in the AD patients, the scores of memory and language were significantly lower than those in the AD patients(P<0.05), while the scores of concentration were significantly higher than those in AD patients. In terms of WHO-UCLA AVLT scores, the scores of delayed memory a long-term memory in VD patients were significantly higher than those in AD patients(P<0.05).Conclusion　Both AD and VD patients have the symptoms of mental and behavioral disorders and some differences in the symptoms between them, which has a certain reference value for differentially diagnosing the two diseases.]]> 2017/6/22 9:55:21 YANG Ran, ZHANG Bao-hua, FU Zhi-xin, et al. 197true ［Abstract］　Objective　To investigate the improving effect of repetitive transcranial magnetic stimulation on motor function in the patients with stroke.Methods　One hundred patients with stroke who were treated in the rehabilitation department of our hospital from June 2013 to July 2015 were collected, and were randomly divided into the rTMS group and the control group, with 50 cases in each group. The control group was treated with rehabilitation therapy such as routine medicine, acupuncture and exercise. The rTMS group was treated with rTMS on the basis of the rehabilitation therapy in the control group. The changes of the motor function(Fugl-Meyer) scores, neurological deficit(NIHSS) scores and the daily living ability(FIM) scores were compared between the two groups before and after the treatment.Results　After the treatment, the Fugl-Meyer and FIM scores were significantly more than those before the treatment in the two groups, the NIHSS scores were significantly less than those before the treatment(P<0.05). After the treatment, the Fugl Meyer and FIM scores in the rTMS group were significantly more than those in the control group, the NIHSS scores were significantly less than those in the control group(P<0.05). There were no obvious adverse reactions during the treatment period in the two groups.Conclusion　rTMS is an effective, non-invasive and safe treatment method for impoving the limb motor function in the patients with stroke.]]> 2017/6/22 9:55:21 LIU Chun-min 196true ［Abstract］　Objective　To explore the influencing factors of standardized hypertension management(SHM) in rural communities of Tiandong county, Guangxi Zhuang Autonomous Region, and to provide the basis and reference for the strategy of rural community SHM in Tiandong county.Methods　According to the Chinese guidelines of hypertension management, 103 hypertensive patients who were selected from the physical examinees in rural communities of the health centers were managed for 12 months, and were analyzed the influencing factors associated with blood pressure treatment.Results　After SHM, the average values of systolic pressure and diastolic pressure declined, and the blood pressure control rates rose before the management among the communities（P<0.05）. In multivariate logistic regression analysis, local registered residence（OR=10.258） and antihypertensive therapy before standardization management（OR=86.947） were the positive factors influencing the effect of blood pressure treatment, while left ventricular hypertrophy（OR=0.103） and eating salty food（OR=0.011） were the negative factors.Conclusion　SHM can increase the control rates of blood pressure significantly in the rural communities. Health education should be strengthened to control high blood pressure in the patients in rural communities and the therapy should be adjusted individually.]]> 2017/6/22 9:55:21 LI Li-ding 195true ［Abstract］　Objective　To investigate the optimal threshold of 64-slice spiral CT in pulmonary angiography.Methods　Eighty patients with suspected pulmonary embolisms and CT pulmonary angiography were randomly divided into four groups in which the triggering threshold values were 80 HU, 100 HU, 120 HU and 140 HU respectively. They were performed CT pulmonary angiography using 64-slice spiral CT combined with automatic tracking trigger scanning, and the ROIs of trigger points were located in the superior vena cava.Results　The reference group of 100 HU threshold had marked enhancement in pulmonary artery, segmental pulmonary artery and sub-segmental pulmonary, with a high display rate of 6-level pulmonary artery. The mean pulmonary CT value was (442.5±91.7), while enhancement in pulmonary vein was unobvious, with great differences in arteriovenous density, and the display of treated arteries image was clear. The group of 80 HU threshold had lower value of CT pulmonary trunk, with the average CT value being(248.2±74.5), which prompted premature trigger scanning. The group of 120 HU threshold had a significantly increased density of the pulmonary vein, which was almost equal to the pulmonary artery in CT value. The group of 140 HU threshold had significantly decreased density of the pulmonary artery and increased density of the pulmonary vein, whose CT value was greater than the pulmonary artery, suggesting a late trigger scanning, with a significant difference compared with the reference group(P<0.05).Conclusion　In CT pulmonary angiography, automatic tracking trigger scanning of 64-slice spiral CT, has a better quality of the scanned image in the condition that the trigger points are located in the superior vena cava, with the contrast agent being between 35 and 40 ml, the injection flow rate of 4.8 ml/s, and the trigger threshold of 100 HU.]]> 2017/6/22 9:55:21 ZENG Yu-ping, CHEN Guan-shang, LONG Shi-liang, et al. 194true ［Abstract］　Objective　To observe the effect of target-controlled infusion of different doses of sufentanil combined with etomidate on elderly patients with tracheal intubation response.Methods　Forty-eight elderly patients undergoing general anesthesia in our hospital from May 2014 to September 2015 were selected as the research subjects, ASA grade from Ⅱ to grade Ⅲ, and were randomly divided into two groups with 24 cases in each group. The observation group was given target-controlled infusion of sufentanil 0.35 μg/ml and etomidate 0.5 μg/ml for anesthesia induction while the control group was given target-controlled infusion of sufentanil 0.40 μg/ml and etomidate 0.5 μg/ml for anesthesia induction. The hemodynamic changes and the incidence of adverse reactions were compared at the anesthesia induction.Results　According to the result of the analysis, the heart rate and mean arterial pressure in the patients in the observation group were more stable than those in the control group before and after the intubation and 1, 3, 5 and 10 min after the intubation(P<0.05). There were no significant differences in the values of BIS during the induction period between the two groups(P>0.05).Conclusion　Target-controlled infusion of sufentanil 0.35 μg/ml and etomidate 0.5 μg/ml has little effect on the tracheal intubation response in senile patients and has more stable hemodynamics.]]> 2017/6/30 9:13:09 LU Guang-ze, CHEN Wei-zhi, DING Yao-mao, et al. 193true ［Abstract］　Objective　To study the effect of statins on lipid metabolism levels in patients with acute coronary syndrome(ACS) complicated with renal dysfunction.Methods　Ninety-six patients with ACS complicated with renal dysfunction treated in our hospital from February 2013 to July 2014 were selected and randomly divided into 3 groups among whom 40 cases treated with routine drugs such as aspirin, β-blockers, nitrates and angiotensin converting enzyme inhibitors were taken as the routine group. The remaining 56 patients treated with statins based on the routine treatment were taken as the statins group; The statins group was subdivided into two groups, in which 28 patients were treated with low-dose statins were taken as the low-dose group while the other 28 cases were treated with high-dose statins(the high-dose group). The treatment lasted for 3 months. The changes of serum lipids indexes such as total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were observed in the routine group, statins group, low-dose and high-dose group.Results　After the treatment, TC, TG and LDL-C of the statins group were significantly lower than those of the routine group［（4.34±0.63） vs （5.21±0.75）mmol/L,（1.56±0.52） vs （2.15±0.73）mmol/L,（2.43±0.62） vs （2.91±0.81）mmol/L］(P<0.05); TC and TG of the high-dose group of the statins group were significantly lower than those of the low-dose group［（4.04±0.65） vs （4.65±0.68）mmol/L,（1.24±0.57） vs （1.75±0.74）mmol/L］(P<0.05).Conclusion　Statins can effectively reduce the lipid level in patients with ACS and complicated with renal dysfunction and the effect of high-dose statins is better.]]> 2017/6/30 9:13:09 ZHOU Chun-juan 192true ［Abstract］　Objective　To investigate the effects of dexmedetomidine on general anesthesia in patients with gynecological laparoscopic surgery.Methods　One hundred and four cases with uterine myoma or ovary cyst were performed laparoscopic surgery and were divided into the observation group(treated with dexmedetomidine) and the control group(treated with normal saline) by the digital method, with 52 cases in each group. The anesthetic effect and safety during recovery period were compared between the two groups.Results　MAPS were (101.84±5.41), (91.38±5.06), (90.0±4.89) and (86.47±4.32)mmHg respectiveiy at the time of extubation and 5, 10, 15 minutes after extubation. HRS were (88.34±6.45), (83.48±5.78), (81.53±5.15) and (80.02±4.47)times/min respectiveiy at the time of extubation and 5, 10, 15 minutes after extubation. The improvements of MAP and HR in the observation group were significantly better than those in the control group(P<0.05). There were no sigaificant differences between the observation group and the control group in the time of breathing recovery［(5.32±1.83) vs (5.41±1.79)min］, consciousness recovery［(9.22±2.36) vs (9.19±2.41)min］, and in the extubation time［(11.89±2.88) vs (11.95±2.79)min］(P>0.05). Riker sedation and agitation scores, and the incidence of agitation were［ (4.03±0.57) vs (5.32±1.63), 5.77% vs 34.62%］ in the observation group and the control group(P<0.05).Conclusion　Dexmedetomidine can make more stable hemodynamics and rapid and complete postoperative recovery during gynecologic laparoscopic surgery.]]> 2017/6/30 9:13:09 ZHANG Jie 191true ［Abstract］　Objective　To investigate the effect of proteasome dysfunction on the pathogenesis of sporadic Parkinson′s disease.Methods　The rat model of proteasome dysfunction was made by injecting protease inhibitor into the right site of substantia nigra(the observation group, n=50）. The rats in the control group（n=50） were injected with saline injection(n=50). The changes of behavior, the Louis(small) formation rate evaluated by HE staining and the expression of α-synuclein（α-Syn） in substantia nigra detected by reverse transcription-polymerase chain reaction(RT-PCR) and Western blotting molecular biology were compared between the two groups.Results　The Louis(small) formation rate in the observation group was significantly higher than that in the control group(P<0.01). The levels of the expression of α-Syn in the observation group were significantly higher than those in the control group(P<0.01).Conclusion　Proteasome dysfunction can lead to high Louis(small) formation rate and the expression of α-Syn in the substantia nigra, which is a risk factor for the pathogenesis of sporadic Parkinson′s disease.]]> 2017/12/22 10:21:37 LU Jian-jun, WANG Zhan-hang, WANG Yu-zhou, et al. 190true ［Abstract］　Objective　To evaluate the therapeutic effect of compound Yixiaofutan decotion combined with mouse nerve growth factor(mNGF) on Type 2 diabeties mellitus complicated with cerebral infarction.Methods　Ninety-eight patients with Type 2 diabeties mellitus complicated with cerebral infarction were collected as the research subjects and were divided into the treatment group(n=49) and the control group(n=49) by random number table. The control group was treated with mNGF plus conventional glucose-lowering treatment, while the treatment group received the same therapy as the control group plus compound Yixiaofutan decotion. The clinical effect, neurologic function, activities of daily living and plasma endothelial function were compared between the two groups 8 weeks after treatment.Results　In the treatment group, 5 cases were cured, 29 cases remarkably effective, 12 cases effective and 3 cases ineffective. In the control group, 2 cases were cured, 23 remarkably effective, 11 cases effective and 13 cases ineffective. The therapeutic effect of the treatment group was obviously superior to that of the control group(P<0.05); The scores of NIHSS and ADL in the treatment group［(5.74±1.28) and (16.57±3.43)］ were significantly lower than those in the control group 8 weeks after treatment(P<0.01). After treatment, the improvements of the levels of ET and NO in the treatment group ［(55.43±6.27)pg/ml and (73.58±7.40)μmol/L］ were better than those in the control group(P<0.01).Conclusion　Compound Yixiaofutan decotion combined with mNGF can effectively improve the blood sugar level and the neural function in the patients with Type 2 diabeties mellitus complicated with cerebral infarction and improve their clinical curative effects.]]> 2017/12/22 10:21:37 LIU Zheng-guo, BAO Zhi-ying, QI Qin 189true ［Abstract］　Objective　To analyze the effects of prenatal routine examination on perinatal outcomes in parturients with early onset severe preeclampsia.Methods　Ninety parturients with early onset severe preeclampsia were collected in our hospital from July 2012 to May 2015, and were divided into the observation group and the control group according to whether or not they received prenatal routine examination, with 45 cases in each group. The control group did not receive any prenatal routine examination and clinical treatment before admission to the hospital. The observation group received prenatal routine examination and clinical treatment before admission. The clinical data were retrospectively analyzed in the two groups and their perinatal outcomes were compared.Results　The incidences of neonatal asphyxia, neonatal death and intrauterine death in the observation group were significantly lower than those in the control group(4.4% vs 20.0%, 2.2% vs 20.0%, 4.4% vs 24.4%)(P<0.05). The incidences of the complications of preeclampsia, renal damage, placental abruption in the observation group were significantly lower than those in the control group(2.2% vs 13.3%, 6.7% vs 31.1%, 2.2% vs 13.3%)(P<0.05). There were no significant differences in the incidences of postpartum hemorrhage and hepatic function damage between the two groups(P>0.05).Conclusion　Prenatal routine examinations before hospitalization can effectively reduce the incidences of perinatal asphyxia, neonatal death, intrauterine death and maternal complications in the parturients with early onset severe preeclampsia.]]> 2017/12/22 10:21:37 HUANG Li-jun 188true ［Abstract］　Objective　To study the safety and efficacy of ultrasound-guided percutaneous transhepatic gallbladder drainage(PTGD) combined with scheduled laparoscopic cholecystectomy(LC) in the treatment of acute severe cholecystitis.Methods　Eighty-two patients with acute severe cholecystitis were collected in our hospital during April 2015 and April 2016, and were divided into the observation group(n=41) and the control group(n=41) according to the different surgical methods. The observation group received ultrasound-guided PTGD treatment, to which scheduled LC was added after 3～4 weeks. The control group received emergency LC. The treatment results were compared between the two groups.Results　The operation time of the observation group was longer than that of the control group, and the intraoperative conversion rate of the observation group was higher than that of the control group(P<0.05). The incidence of complications of the observation group was significantly lower than that of the control group(P<0.05).Conclusion　Ultrasound-guided PTGD combined with scheduled LC is safe and effective for the patients with acute severe cholecystitis, with advantages of less trauma, fewer complications and faster recovery.]]> 2017/11/28 17:12:43 LI Long, DING Jie, PAN Hong-bo 187true ［Abstract］　Objective　To investigate the effects of different insulin treatments on islet cell function in the patients with type 2 diabetes mellitus.Methods　Fifty patients with type 2 diabetes were divided into the observation group and the control group according to the different treatment methods, with 25 cases in each group. The control group was given insulin aspart combined with insulin glargine and the observation group was treated with insulin aspart combined with insulin detemir. Both of the two treatments lasted for 3 months. The levels of fasting insulin, postprandial 2 h insulin, C peptide, HbA1c and fructosamine were compared between the two groups.Results　There were no significant differences in the levels of fasting and postprandial 2 h C peptide and insulin indexes between the two groups before the treatment(P>0.05); The levels of fasting insulin and C peptide were significantly increased in both of the two groups after the treatment(P<0.05); The level of 2-hour postprandial insulin in the observation group was significantly increased compared with that before the treatment, and significantly higher than that of the control group(P<0.05). Compared with those before the treatment, the levels of HbA1c and fructosamine were significantly decreased in both of the two groups(P<0.05).Conclusion　Insulin aspart combined with insulin detemir can significantly improve the islet cell function and is more effective than insulin aspart combined with insulin glargine in the treatment for the patients with type 2 diabetes.]]> 2017/11/28 17:12:43 LIU Na 186true ［Abstract］　Objective　To investigate the effects of exercise therapy on cardiac function and exercise tolerance in patients with acute myocardial infarction(AMI).Methods　Forty-eight patients with acute ST-segment elevation myocardial infarction(STEAMI) were collected in our hospital from January 2013 to November 2015, and were randomly divided into the exercise group and the control group. The exercise group was treated with intravenous thrombolytic therapy plus conventional drug therapy and exercise therapy. The control group was treated with intravenous thrombolytic therapy plus conventional drug therapy and routine treatment. The clinical symptoms, N-terminal-pro-B-type natriuretic peptide(NT-proBNP), left ventricular ejection fraction(LVEF), 6 minutes walking distance(6MWD) and exercise capacity were compared between the two groups at the beginning of exercise therapy and 6 months after the therapy.Results　After a follow-up of 6 months, compared with those in the control group, the level of NT-proBNP was significantly lower, and the levels of LVEF, 6MWD and exercise tolerance were significantly higher in the exercise group(P<0.01).Conclusion　Exercise therapy can significantly improve the cardiac function and exercise tolerance in the patients with AMI, and improve the quality of life.]]> 2017/11/28 17:12:43 PENG Ren-cong, MA Pei-rong, ZHANG Ling, et al. 185true ［Abstract］　Objective　To investigate the clinical effect between anatomic plate and locking plate on the treatment of distal tibial Pilon fracture of Ruedi-Allgower type Ⅲ.Methods　The clinical data of 80 patients with Pilon fractures of Ruedi-Allgower type Ⅲ treated in our hospital from October 2005 to October 2015 were retrospectively analyzed. Group A(n=40) underwent anatomic plate internal fixation treatment. Group B(n=40) received locking plate internal fixation for the treatment. The clinical effects were compared between the two groups.Results　The operation time and average healing time of group B was significantly shorter than that of group A(P<0.05). There were no significant differences between the two groups in Tornetta evaluation and Burwell Chamley radiological evaluation（P>0.05）.Conclusion　Locking plate has shorter healing time and shorter operation time than anatomical plate in the treatment of Pilon fracture of Ruedi-Allgower type Ⅲ.]]> 2017/11/28 17:12:43 HUANG Ke, SUN Ke 184true ［Abstract］　Objective　To observe the curative effect of dislocation decompression and reconstruction on the treatment of thoracolumbar spine fractures by paraspinal muscle approach.Methods　70 patients with dislocation of fracture in our hospital from July 2014 to July 2015 were randomly divided into the study group and the control group, with 35 cases in each group. Both of the two groups were treated with one-stage reconstruction treatment. The control group was operated by the middle approach, and the study group received the surgery by the paravertebral approach. The indexes during the periods of the perioperation and recovery and the occurrence of complications were compared between the two groups.Results　The indexes of the perioperation and recovery in the study group improved better than those in the control group(P<0.01). The complication rate of the study group decreased more obviously than that of the control group(P<0.05).Conclusion　The use of the adjacent muscle gap approach can significantly reduce the surgical trauma, accelerate the postoperative recovery, reduce the complications, and improve the stability of the spine during the first stage decompression and reconstruction.]]> 2017/10/26 8:15:41 ZHANG Zhen-yu 183true ［Abstract］　Objective　To observe the long-term effect of self-made acupuncture-moxibustion prescription on the treatment of perennial allergic rhinitis.Methods　119 cases with perennial allergic rhinitis were enrolled, and they received consecutively 10 times acupuncture and moxibustion treatment once a week according to self-made acupuncture-moxibustion prescription. Visual Analogue Scale(VAS) was applied to assign scores to the patients′ nasal and general symptoms and the changes of the scores were compared before and 12 months after the treatment.Results　81 patients completed the treatment, in whom 49 cases were markedly effective, 20 cases effective and 12 cases ineffective. The total effective rate was 85.19%. The scores of the symptoms of both overall and classified nasal 12 months after the treatment were lower than those before the treatment(P<0.01).Conclusion　The self-made acupuncture-moxibustion prescription has a long-term good effect on the treatment of perennial allergic rhinitis.]]> 2017/10/26 8:15:41 MENG Ti-hang, LIANG Jie-ling, HUANG Hao, et al. 182true ［Abstract］　Objective　To explore the clinical effects of pulmonary surfactant on treatment of full-term neonatals with severe acute respiratory distress syndrome.Methods　74 full-term newborns with acute respiratory distress syndrome in our hospital from February 2015 to April 2016 were randomly divided into the observation group and the control group by the random number table method, with 37 cases in each group. The control group was given conventional treatment, while the observation group was treated with the same treatment as the control group plus pulmonary surfactant. The clinical effects and 24-hour blood gas indexes were compared between the two groups before and after the treatment.Results　In the observation group,15 cases were markedly effective, 20 cases effective and 2 cases ineffective, while in the control group, 9 cases were markedly effective, 19 cases effective, and 9 cases ineffective, with a better clinical effect in the observation group(P<0.05). Before the treatment, there were no significant differences in the indexes of blood gas analysis between the two groups(P>0.05). After the treatment, the values of PaO₂, PaCO₂ and pH in the observation group were improved better than those in the control group(P<0.01).Conclusion　Pulmonary surfactant is effective in the treatment of acute respiratory distress syndrome in full-term neonates.]]> 2017/10/26 8:15:41 YU Wen-li 181true ［Abstract］　Objective　To study CT-guided percutaneous lung biopsy in peripheral pulmonary lesions.Methods　60 patients who were performed CT-guided percutaneous lung biopsy in our hospital from 2013 to 2016 were collected.Results　The pathological results were obtained in 60 cases, and 51 cases were proved to be malignant tumors, accounting for 85.0%. 7 cases were complicated with pneumothorax（11.7%）, and no hemoptysis was found.Conclusion　CT-guided percutaneous lung biopsy has high diagnostic efficiency and relatively low incidence of complications.]]> 2017/10/26 8:15:41 ZHOU Guo-yong, LIANG Shu-sheng, ZHANG Cui-lu, et al. 180true ［Abstract］　Objective　To investigate the clinical characteristics of primary aldosteronism patients with normal serum potassium. Methods　From January 2013 to December 2016, the patients with primary aldosteronism in Dongguan Hospital of Traditional Chinese Medicine were divided into hypokalemia group(60 cases) and normal potassium group(80 cases). The clinical, biochemical and imaging data were retrospectively analyzed. Results　 Grade1 and grade 2 hypertension were more common in the hypokalemia group, while grade 2 and grade 3 were more common in the normal blood potassium group(P<0.05). The serum sodium in the hypokalemia group ［(149.79±4.23)mmol/L］ was higher than that in the normal blood potassium group ［(140.23±2.86)mmol/L］(P<0.05), while the blood potassium in the low potassium group ［(2.97±0.2)mmol/L］ was lower than that in the normal potassium group ［(3.92±0.3)mmol/L］(P<0.05). There were no significant differences in the sitting renin activity and the level of the sitting aldosterone between the two groups(P>0.05). Aldosterone producing tumors was more common in the hypokalemia group, while idiopathic hyperaldosteronism was more common in the normal potassium group. There were significant differences in adrenal lesions between the two groups(P<0.05). There were no significant differences in the damage of target organs such as left ventricular hypertrophy, carotid plaque, chronic renal insufficiency and cerebral infarction between the two groups(P>0.05). Conclusion　The clinical manifestations of primary aldehyde patients with normal serum potassium are various, mainly characterized by moderate and severe hypertension, and idiopathic hyperaldosteronism is their main classification type.]]> 2018/9/30 16:15:19 ZHONG Zuan-yi, HUANG Shu-ling, ZHOU Yu-qing, et al. 179true ［Abstract］　Objective　To explore the clinical effect of dexmedetomidine on prevention of tourniquet reaction during long-time operation of upper limbs. Methods　70 patients undergoing replantation of severed fingers and severe wrist trauma were treated in our hospital from January 2016 to June 2017 and were treated with brachial plexus block for a long time. They were randomly divided into the observation group(n=36) and the control group(n=34). The two groups were guided by B-ultrasound to achieve intermuscular groove brachial plexus block which had a better effect on anesthesia. The observation group was given dexmedetomidine after tourniquets were inflated, with a dose of 1 μg/kg for 10 min of continuous pumping, followed by 0.4 μg/(kg·h) continuouely pumped to 10 min before the end of the operation. The control group received infusion of 0.9% sodium chloride injection in the same way after tourniquets were inflated. The mean arterial pressure(MAP), heart rate(HR) and blood oxygen saturation(SpO₂) before tourniquet inflation(T₁), 2 hours(T₂), 3 hours(T₃), 4 hours(T₄), 5 hours(T₅) and 6 hours(T₆) after tourniquets and Ramsay sedation scores of evaluating sedation and analgesia at different time points of T₁～T₆, and the incidence of adverse reactions were recorded. The levels of elbow arterial blood lactic acid were detected before and after surgery. The concentrations of malondialdehyde(MDA) and superoxide dismutase(SOD) in the elbow vein were recorded before operation(T₁), 3 hours after operation(T₇), 24 hours after operation(T₈), and 48 hours after operation(T₉). Results　There were no significant differences in the levels of MAP, HR, SpO₂ and Rams scores between the two groups at T₁ and T₂(P>0.05). The levels of MAP and HR were significantly lower and the Rams scores were significantly higher at T₃～T₆ in the observation group than those in the control group(P<0.05). There were no significant differences in the levels of SpO₂ between the two groups at T₃～T₆(P>0.05). 5 cases occurred sinus bradycardia in the observation group and their aLac values were lower after operation(P<0.05). Compared with those at T₁, MDA increased and SOD decreased at the time points of T₇, T₈ and T₉ in both of the two groups(P<0.05). MDA was significantly lower and SOD was significantly higher in the observation group than those in the control group(P<0.05). Conclusion　Dexmedetomidine effectively prevents the occurrence of tourniquet reaction during long-time operation of upper limbs and significantly improves the tissue hypoxia caused by tourniquet and reduces the ischemia-reperfusion injury caused by tourniquet.]]> 2018/9/30 16:15:19 WANG Zhen-yu, YANG Fu-guo, QI Zheng, et al. 178true ［Abstract］　Objective　To explore a satisfactory way of anesthesia for aged patients undergoing inguinal tension-free hemioplasts. Methods　Inguinal tension-free hemioplasty was performed on 42 aged patients in our hospital from January 2015 to April 2016. The patients were divided into group H and group T according to different anesthesia methods. Group H(n=21) used laryngeal mask for anesthesia alone, and group T(n=21) used ultrasound-guided transversus abdominis plane block combined with laryngeal mask anesthesia. The blood pressure and heart rate, intraoperative and postoperative analgesic dosages, time to remove laryngeal mask, postoperative visual analogue scale(VAS) and anesthesia satisfaction rate were compared between the two groups at difference time points. Results　Compared with those in group T, the blood pressure and heart rate in group H were significantly higher at T₃(traction peritoneum) and T₄(6 h after surgery)(P<0.05). In group H, compared with those at T₀(before anesthesia), T₂(after skin incision ) and T₅(24 h after surgery), the blood pressure and heart rate were significantly higher at T₃(traction peritoneum) and T₄(6 h after surgery)(P<0.05). Compared with those in group T, the time to remove laryngeal mask was significantly longer, and the postoperative VAS scores were significantly higher and the satisfactory rate was significantly lower in group H(P<0.05). Conclusion　Ultrasound-guided transversus abdominis plane block combined with laryngeal mask is effective in anesthesia for the aged patients undergoing inguinal tension-free hemioplasty.]]> 2018/9/30 16:15:19 FAN Jian-long 177true ［Abstract］　Objective　To study the effect of devascularization on liver function in patients with cirrhosis and portal hypertension. Methods　82 patients with cirrhosis and portal hypertension were selected and divided into two groups according to different treatment methods, with 41 cases in each group. The control group received double interventional embolization, and the study group received devascularization therapy. The changes of blood routine examination and liver function, and treatment results were compared between the two groups before and 1 month after treatment. Results　There were no significant differences between the two groups in blood routine and liver function before treatment(P>0.05). One month after treatment, the platelet count and white blood cell count of the study group were significantly higher than those of the control group(P<0.05). The prothrombin activity and albumin content in the study group were significantly higher than those in the control group［(79.4±5.2)% vs (69.3±6.0)%, (28.6±2.1)g/L vs (24.0±2.8)g/L］(P<0.05). There were no significant differences between the two groups in red blood cell count, total bilirubin and alanine aminotransferase content(P>0.05). The recurrence rate of the study group(7.3%) was significantly lower than that of the control group(26.8%)(P<0.05). There was no significant difference in the mortality rate between the study group(4.9%) and the control group(9.8%)(P>0.05). Conclusion　Devascularization can help to improve the levels of blood cells and liver function, reduce the recurrence rate and improve the prognosis in patients with liver cirrhosis and portal hypertension.]]> 2018/9/30 16:15:19 QIN Sheng-li 176true ［Abstract］　Objective　To compare and analyze the clinical effects of rosuvastatin and atorvastatin in the treatment of coronary heart disease. Methods　160 patients with coronary heart disease were selected in the Department of Cardiology of our hospital from June 2014 to September 2016 and were randomly divided into the observation group and the control group, with 80 cases in each group. The observation group was given rosuvastatin treatment, and the control group was given the same dose of atorvastatin for continuous 12 months. The levels of serum lipid, high sensitivity C reactive protein(hs-CRP), homocysteine(Hcy) and carotid intima-media thickness(IMT) were compared between the two groups before and after treatment. The incidence of adverse reactions was compared between the two groups after treatment. Results　After treatment, the levels of TC, TG and LDL-C decreased, and the level of HDL-C increased in both of the two groups. The improvements of TC［(4.01±0.50)mmol/L］, TG［(1.44±0.49)mmol/L］, LDL-C［(1.95±0.32)mmol/L］ and HDL-C［(1.79±0.14)mmol/L］ in the observation group were better than those in the control group［(4.78±0.49)mmol/L, (1.69±0.41)mmol/L, (2.35±0.39)mmol/L and (1.15±0.11)mmol/L］ after treatment(P<0.05). The levels of hs-CRP, Hcy, carotid artery IMT and the incidence of adverse reactions in the observation group were significantly lower than those in the control group after treatment(P<0.05). Conclusion　For the patients with coronary heart disease, at the same dose, the lipid-lowering effect of rosuvastatin is superior to atorvastatin and the incidence of adverse reactions of rosuvastatin is lower than that of atorvastatin.]]> 2018/9/30 16:15:19 HU Jian-guo 175true ［Abstract］　Objective　To study the clinical effect of atorvastatin on coronary heart disease and angina pectoris. Methods　One hundred and twenty patients with coronary heart disease and angina pectoris were enrolled in our hospital from January 2016 to April 2017. The patients were divided into control group and observation group by random number method. The control group was given trimetazidine treatment. The observation group was treated with atorvastatin plus trimetazidine. All the patients were treated for two months. The total effective rate, the incidence of adverse reactions, the levels of serum lipids, serum high sensitivity C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) were compared between the two groups. Results　33 cases of observation group marked effectivness, 23 cases effectivness and 4 cases failuer, 24 cases of control group merked effectivness, 23 cases effectivness and 13 case failuer. The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the levels of LDL-C, TG and TC in the observation group were significantly lower than those in the control group, and HDL-C in the observation group was significantly higher than that in the control group(P<0.05). The levels of serum hs-CRP and BNP in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion　Atorvastatin can effectively regulate blood lipid levels and has a significant effect on patients with coronary heart disease and angina pectoris.]]> 2018/9/30 16:15:19 HUANG Zhong-li, HUANG Yan-chun, LI Ming 174true ［Abstract］　Objective　To study the effect of comprehensive treatment of Traditional Chinese Medicine(TCM) on epilepsy after stroke in elderly patients. Methods　44 elderly patients with epilepsy after stroke treated in our hospital from January 2017 to June 2017 were selected and were randomly divided into the research group and the control group according to different treatment methods, with 22 cases in each group. The control group received routine clinic treatment. The research group was treated with comprehensive therapy of TCM plus the routine clinic treatment.The follow-up period was 1 year, and the clinical efficacy was compared between the two groups. Results　The improvement rate of electroencephalogram(EEG) in the the research group was better than that in the control group（P<0.05）. The clinical efficacy of the research group(90.9%) was better than that of the control group(45.5%)（P<0.05）. Conclusion　Comprehensive therapy of TCM is effective in treatment of epilepsy after stroke in elderly patients.]]> 2018/9/30 16:15:19 HONG Rong-qing, LI Lian-ying, GUAN Jin-zhen 173true ［Abstract］　Objective　To analyze the efficacy and safety of laparoscopy combined with choledochoscopy in treatment of gallstones. Methods　100 patients with cholecystolithiasis admitted to our hospital from March 2014 to April 2016 were divided into the observation group(treated with laparoscopy combined with choledochoscopy, n=50) and the control group(treated with laparoscopy, n=50) according to different operative methods. The surgical efficacy and safety were compared between the two groups. Results　The intraoperative blood loss, postoperative 24 h pain scores and hospitalization time in the observation group were significantly lower or shorter than those in the control group. The incidence of postoperative complications in the observation group was lower than that in the control group(P<0.05). The gallbladder contraction function and thickness of gallbladder wall in the observation group improved significantly after the operation（P<0.05）. Conclusion　Laparoscopy combined with choledochoscopy is safer and more effective than laparoscopic cholecystectomy for the patients with gallstones. Laparoscopy combined with choledochoscopy can shorten the time of hospitalization, reduce the postoperative complications, and improve the postoperative gallbladder function.]]> 2018/9/30 16:15:19 LIU Xiang-wei 172true ［Abstract］　Objective　To explore the clinical value of community-based comprehensive intervention model for venous prethrombotic state and the value of ultrasound in detecting deep venous prethrombotic state of lower extremities. Methods　The ultrasonic, biochemical and physical manifestations of 300 cases of stage Ⅱ hypertension with different prethrombotic states of deep vein of lower extremities were studied. According to DOLL′s random distribution card, they were randomly divided into two groups: intervention group and control group. Each group was divided into 3 grades according to the Comprehensive Prevention and Treatment Table for Venous Lesions of Lower Extremity(CPTTVLLE). The intervention group was treated with community comprehensive intervention for two years. Results　The scores of CPTTVLLE and the grades in the intervention group were significantly lower than those in the control group(P<0.05). Conclusion　Ultrasound combined with blood biochemical examination is helpful for the diagnosis of deep venous prethrombotic state of lower extremity in hypertension, and community comprehensive intervention has important clinical value in the prevention and treatment of prethrombotic state of lower extremity in hypertension.]]> 2018/9/30 16:15:19 WANG Feng-run, FENG Dong-min, HUANG Jian 171true ［Abstract］　Objective　To explore the effects of extracorporeal circulation combined with ultrafiltration on lung function after heart surgery in infants and young children with low body mass. Methods　50 infants and young children with low body mass were collected in our hospital from April 2015 to March 2016. Before cardiac surgery, the patients were divided into two groups according to the different treatment methods, with 25 cases in each group. The control group received routine ultrafiltration and the observation group was given routine ultrafiltration+zero-equilibrium ultrafiltration+modified ultrafiltration. The lung function and the levels of plasma protein and erythrocyte ratio(HCT) were compared between the two groups. Results　After the surgery, the alveolar arterial oxygen differential pressure ［(A-a)DO₂］ was significantly lower and the pulmonary static compliance and oxygenation index were significantly higher in the observation group than those in the control group (P<0.05). The levels of plasma protein and HCT in the observation group were significantly higher than those in the control group(P<0.05). Conclusion　Extracorporeal circulation combined with ultrafiltration can effectively reduce the lung injury after heart surgery and improve their lung function in the infants and young children with low-body mass.]]> 2018/8/24 16:25:15 LIU Xu 170true ［Abstract］　Objective　To observe the effects of laparoscopic surgery and transabdominal surgery on the levels of anti-mullerian hormone(AMH), cluster of differentiation 4(CD4) and cluster of differentiation 8(CD8) in the patients with ovarian cyst. Methods　Eighty patients with ovarian cysts admitted to our hospital from March 2014 to January 2016 were divided into the observation group(receiving laparoscopic surgery, n=40) and the control group(receiving abdominal surgery, n=40) according to the different surgical methods. The levels of AMH, CD4 and CD8 were compared between the two groups. Results　The level of AMH in the observation group improved better than that in the control group(P<0.05). After treatment, the levels of CD4 and CD8 in the control group decreased significantly compared with those before treatment, and the levels of CD4 and CD8 were significantly lower than those in the observation group(P<0.05). Conclusion　Laparoscopic surgery is safer and has less adverse effects than abdominal surgery on the ovarian reserve function and postoperative immune function in the patients with ovarian cyst.]]> 2018/8/24 16:25:15 HUANG Cai-xia 169true ［Abstract］　Objective　To explore the clinical effect of hot compress by fennel and abdominal massage on feeding intolerance of premature infants. Methods　140 premature infants with feeding intolerance diagnosed between June 2013 and June 2017 were selected in our hospital, and were randomly divided into the control group and the baby touch group, with 70 cases in each group. The control group received routine therapy and the baby touch group received abdominal massage combined with hot compress by fennel and nursing plus the same treatment as the control group. The main symptoms and the clinical effect, the time of vomiting, abdominal distention, gastric retention disappear and hospitalization, and the total enteral feeding time were compared between the two groups before and 7 days after treatment. Results　Compared with those in the control group 7 days after treatment, the clinical effect was better, and the time of vomiting, abdominal distention, gastric retention disappear and hospitalization, and the total enteral feeding time was shorter in the baby touch group(P<0.05). Conclusion　Hot compress by fennel and abdominal massage can improve the feeding intolerance of premature infants, and the total enteral feeding time and the hospitalization time.]]> 2018/8/24 16:25:15 WANG Gang, MA Hong, ZHANG Huan, et al. 168true ［Abstract］　Objective　To investigate the clinical effect of budesonide combined with compound ipratropium bromide inhalation on treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods　Three hundred patients with AECOPD treated from October 2014 to October 2017 were selected as the observation subjects and divided into two groups according to the randomized drawing method: control group(n=150) and observation group(n=150). The control group was treated with compound ipratropium bromide inhalation. The observation group received the same treatment as the control group plus budesonide inhalation. The clinical efficacy, lung function, changes of blood gas indexes and adverse reactions were compared between the two groups. Results　The total clinical efficiency of the observation group(94.7%) was significantly higher than that of the control group(80.0%)(P<0.05). The forced expiratory volume(FEV1), forced vital capacity(FVC), predicted FEV1, PaO₂ and PaCO₂ in the two groups after 1-hour treatment were significantly lower than those before treatment(P<0.05). The levels of FEV1, FVC, FEV1 accounting for predicted value and PaO₂ in the observation group were significantly higher than those in the control group(P<0.05). The level of PaCO₂ in the observation group was significantly lower than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group(6.7%) and the control group(10.0%)(P>0.05). Conclusion　Budesonide combined with compound ipratropium bromide inhalation is effective in treatment of AECOPD. It can improve pulmonary function and blood gas indexes, but does not increase adverse reactions.]]> 2018/8/24 16:25:15 LIN Shu-mei, HUANG Jun-xian, CHEN Li-hua 167true ［Abstract］　Objective　To investigate the advantages of dual-band doppler ultrasonography in measuring the umbilical arteries in fetuses and to study the correlation of blood flow variation of two umbilical arteries in fetuses. Methods　The umbilical cords of the fetuses in two hundred pregnant women at 28～42 weeks′ gestation were scanned routinely with the dual-band doppler ultrasonography. The blood flow of the two umbilical arteries in the fetuses were displayed simultaneously (group a and b).The S/D ratio and resistance index (RI) were measured at the same time. The real time blood flow changes of the two umbilical arteries in the fetuses were showed and the correlation was analyzed. Results　The S/D ratio and resistance index of the two umbilical arteries in the normal fetuses have the downtrend with the increase in gestational age.There were no significant differences in the S/D ratio and resistance index between the two umbilical arteries in the normal fetuses. Conclusion　The dual-band doppler ultrasonography has more advantages than the traditional single-band doppler ultrasonography in the real-time display of the blood flow of two umbilical arteries in fetuses which can find the umbilical cord diseases earlier and predict the fetal distress better. It also helps to choose the correct mode of delivery and avoid the fetus intrauterine anoxia.]]> 2018/8/24 16:25:15 SUN Bo 166true ［Abstract］　Objective　To analyze the clinical manifestations and endoscopic treatment of extraneous foreign bodies in the upper digestive tract. Methods　165 cases of exogenous foreign body in the upper digestive tract from October 2004 to May 2016 were treated with OlympusV-70 and OlympusCV-150 electronic gastroscope and Olympus CV-260 electronic gastroscope. Results　165 cases of endoscopic treatment were performed, of which 3 cases of school-age children were treated with propofol(1～2 mg/kg) for painless gastroscopy under intravenous anesthesia, 74 cases assisted with gastroscope mantle, 21 cases of relatively smooth esophageal foreign bodies from the lower reaches of the endoscopy, and 65 cases of gastric foreign body. After the endoscopy, 15 patients no treatment was performed, and the foreign bodies of the 15 patients were discharged spontaneously. 50 patients were removed under endoscopy. 2 cases were treated with surgery. All patients with the foreign bodies were cured. Conclusion　The treatment of extrinsic foreign bodies in upper digestive tract with endoscopic treatment is satisfactory and worthy of popularization and application.]]> 2018/8/24 16:25:15 YANG Bin-hai, ZHANG Zhi-hua 165true ［Abstract］　Objective　To observe the clinical effect of anatomical locking plate internal fixation on treatment of C1 and C2 types distal radius fractures. Methods　120 cases of C1 and C2 types distal radius fractures in our hospital were selected and were divided into two groups by stratified random method. The observation group(n=60) was treated with anatomical locking plate internal fixation, while the control group(n=60) received conservative treatment. The clinical efficacy was compared between the two groups. Results　The excellent and good rate was 88.33% in the observation group and 75% in the control group. The excellent and good rate of wrist side recovery in the observation group was higher than that in the control group（Z=-2.794, P=0.005）. There were no significant differences in VAS scores between the two groups before operation(P>0.05). The VAS scores in the two groups after operation were significantly lower than those before operation(P<0.05). The VAS scores of the observation group were significantly lower than those of the control group(P<0.05). Conclusion　Anatomical locking plate internal fixation is effective for the treatment of C1 and C2 types distal radius fractures, and its clinical effect is better than that of the conservative treatment.]]> 2018/8/24 16:25:15 WEI Jian, LIN Qiang-zhen, LAN Gen 164true ［Abstract］　Objective　To observe the clinical effect of repositioning maneuver combined with medication on treatment of benign paroxysmal positional vertigo(BPPV). Methods　115 patients with BPPV admitted from August 2015 to December 2017 were randomly divided into the observation group(n=57) and the control group(n=58). The observation group was treated with repositioning maneuver combined with medication, and the control group was treated with medication. The clinical effect was compared between the two groups. Results　The total effective rate of the observation group(94.73 %) was significantly higher than that of the control group(72.41%) （χ²=10.387, P<0.05）. The therapeutic effect of the observation group was better than that of the control group（Z=-5.304, P<0.05）. Conclusion　Repositioning maneuver combined with medication is effective in treatment of benign paroxysmal positional vertigo.]]> 2018/8/24 16:25:15 WANG Wei, HUANG Tao-tao, HUAN Jia-jun, et al. 163true ［Abstract］　Objective　To investigate the clinical effect of edaravone combined with monosialotetrahexosylganglioside sodium on acute cerebral infarction. Methods　86 patients with acute cerebral infarction were selected in our hospital from January 2016 to June 2017 and were randomly divided into two groups, with 43 cases in each group. The control group received edaravone(30 mg, ivgtt, bid), and the treatment group received edaravone(30 mg, ivgtt, bid) combined with monosialotetrahexosylganglioside sodium(100 mg, ivgtt, qd) for 14 d. The clinical efficacy was compared between the two groups. Results　The curative effect of the treatment group was significantly better than that of the control group(P<0.05). At the time of admission, there were no significant differences in the levels of serum hypersensitive C reactive protein(hs-CRP) and homocysteine(Hcy), NIHSS and BI scores between the two groups(P>0.05). After the treatment, the above indicators were significantly better than those at the time of admission in both of the two groups, and the indicators of the treatment group were significantly better than those of the control group(P<0.05). Conclusion　Edaravone combined with monosialotetrahexosylganglioside sodiumcan can significantly improve the clinical efficacy, reduce the inflammatory response and serum Hcy levels, improve the neurological function and enhance the ability of daily activities in the patients with acute cerebral infarction.]]> 2018/8/24 16:25:15 CHENG Xiang 162true ［Abstract］　Objective　To retrospectively analyze the irregular antibodies of RBC blood type screening and identification in 32 560 patients with blood transfusion, and to provide valuable information for transfusion safety. Methods　The irregular antibodies were screened by microcolumn gel method in 32 560 patients before blood transfusion, and antibody identification was performed for the positive samples by spectral cell. Results　160 cases were screened out irregular antibodies (0.49%), in which specific antibodies were in 138 cases(86.25%) and non-specificity antibodies in 22 cases(13.75%). The positive detection rate of the irregular antibodies in the female patients(0.76%) was significantly higher than that in the male patients(0.28%) （P<0.05）. The production of irregular antibodies was correlated with a history of pregnancy and blood transfusion (P<0.05). The positive rate was higher in the patients who had hematologic disease, gynecological and obstetric diseases(including normal pregnancy childbirth puerpera) and chronic renal disease, which accounted for 1.03%, 0.95% and 0.86%, but the positive rate was lower in the patients who had surgical diseases(0.26%). Conclusion　Screeing and identification of irregular antibodies in the patients before blood transfusion is important for understanding the intracorporal situation and specificity of the patients, and can reduce the adverse reactions of blood transfusion, and ensure the safety and effect of blood transfusion.]]> 2018/8/24 16:25:15 YAO Rui-ying, JING Chun-xu 161true ［Abstract］　Objective　To investigate the clinical efficacy of Deanxit combined with rabeprazole in treatment of glous hystericus and the follow-up relapsing rate. Methods　63 patients with glous hystericus were selected in our hospital from March 2015 to March 2017, and were randomly divided into the observation group(n=32) and the control group(n=31) according to random number table. The control group received rabeprazole. The observation group was treated with Deanxit plus rabeprazole. The two groups were treated for 8 weeks. The curative effect, the main symptom scores, the anxiety and depression scale scores, and the follow-up relapsing rate were compared between the two groups 6 months after treatment. Results　In the observation group, the treatment result was markedly effective in 21 cases, effective in 10 and ineffective in 1 case. In the control group, the treatment result was markedly effective in 10 cases, effective in 7 and ineffective in 14 cases. The total effective rate of the observation group was higher than that of the control group(P<0.01). In both of the two groups, the scores of pharyngeal discomfort, irritability and anorexia after treatment were significantly lower than those before treatment(P<0.05), and the scores of the observation group after treatment were significantly lower than those of the control group(P<0.01). SAS and SDS scores were decreased in the two groups after treatment(P<0.05), and SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.01).The follow-up relapsing rate of the observation group 6 months after treatment(12.50%) was significantly lower than that of the control group(41.94%)(P<0.05). Conclusion　Deanxit combined with rabeprazole is effective in treatment of glous hystericus. It can relieve anxiety and depression, improve the symptoms and reduce the recurrence rate in the patients.]]> 2018/7/30 16:15:14 XIA Ming, ZHANG Zheng-kun, ZENG Hai-long, et al. 160true ［Abstract］　Objective　To study the related factors of rescuing maternal near miss before and after allowing an extra child(two-child policy). Methods　The clinical data of maternal near miss during January 1, 2015 and December 31, 2015(before allowing an extra child), and during January 1, 2016 and December 31, 2016(after allowing an extra child) were analyzed retrospectively. The basic situation, etiology distribution and maternal-infant outcomes were compared between the two periods. Results　There were no significant differences between 2015 and 2016 in the incidence rates of maternal near miss, but there were significant differences in delivery times between 2015 and 2016（P<0.05）. Postpartum hemorrhage occurred in 11 cases(26.83%) due to placental disorder in 2015, and in 30 cases(63.83%) in 2016, with a significant difference between 2015 and 2016（P<0.05）. Conclusion　Strengthening multiparous perinatal care can diagnose and treat maternal near miss promptly and effectively, and prenatal examination and preoperative evaluation of pregnant women with scar uterus are the key factors to reduce the occurrence of critical pregnant women after two-child policy.]]> 2018/7/30 16:15:14 WANG Cai-shan 159true ［Abstract］　Objective　To analyze the correlation between the different pathological types of endometrium polyps and sex hormones in perimenopausal women. Methods　The clinical data of 132 perimenopausal women receiving the surgery for endometrial polyps in our hospital from January 2014 to June 2017 were retrospectively analyzed. The correlation between the different pathological types of endometrium polyps and the sex hormone indexes was analyzed to evaluate the role of sex hormone related indicators in the development of endometrium polyps. Results　In the 134 patients, the pathological type of endometrium polyps was simple hyperplasia in 92 case(68.66%), complex hyperplasia in 36 cases(26.87%), atypical hyperplasia of simple hyperplasia in 4 cases(2.98%), and atypical hyperplastic hyperplasia in 2 cases(1.49%). There were no significant correlations between the pathological types and the mean follicular estrogen, the mean luteinizing hormone, the mean prolactin hormone and the mean progesterone of the patients(P>0.05). There were positive linear correlations between the pathological types and the mean estrogen and age（r₁=0.293, P₁=0.001; r₂=0.355, P₂=0.000）. With the increase of mean estrogen and age, the potentiality of canceration of the tissues was greater,and there was a negative correlation between the mean androgen and pathological types（r=-0.299, P=0.000）. With the decrease of mean androgen, the risk of tissue malignancy increased. Conclusion　The combination of estrogen and androgen has a certain reference value in predicting the risk of malignant transformation of endometrial polyps and it is more noninvasive than histopathological examination in detecting the malignant transformation tendency of endometrial polyps in perimenopausal women.]]> 2018/7/30 16:15:14 CHEN Jun-yu, WU Ya-ling, OUYANG Yan-lan, et al. 158true ［Abstract］　Objective　To explore the clinical effect and aesthetic value of coronally advanced flap and laterally poitioned flap restoration applied to defect after epulis resection. Methods　A total of 60 patients with epulis were selected in our hospitals from August 2015 to July 2017 and received periodental non-surgical treatment and epulis resection by coronally advanced flap and laterally positioned flap according to the conditions of gingival defects. The clinical effect and aesthetic value were evaluated according to the gingival margin, gingival papilla and modified sulcus bleeding indexes. Results　Among the 60 patients with epulis, 18 cases received laterally poitioned flap, and 42 cases received coronally advanced flap. No recurrence was found after a follow-up of 12 months and the various indexes were satisfying. Conclusion　Coronally advanced flap and laterally poitioned flap has satisfactory clinical effect and aesthetic value on restoring the defects after epulis resection.]]> 2018/7/30 16:15:14 SU Wen-hao, LI Qi, WANG Zhao-xing 157true ［Abstract］　Objective　To study the value of contrast agents at low and conventional doses in CT imaging of the pulmonary artery. Methods　The image data of 60 patients with pulmonary embolism diagnosed by clinical examinations and medical images in our hospital were retrospectively analyzed. CTA scan of pulmonary angiography was performed on 30 patients who were injected with 30 ml of contrast agents(low dose group), and on the other 30 patients who were injected with 60 ml of contrast agents(conventional dose group). Then the thin layer image of the pulmonary angiography was analyzed, and the CT values of the main, the right and the left pulmonary trunks, the pulmonary veins and the superior vena cava were measured respectively. Results　The images were satisfactory in all the 60 patients. There were significant differences in the CT values of the main, the right and the left pulmonary trunks, and the pulmonary veins and the superior vena cava between the two groups(P<0.05). Conclusion　In comparison of the contrast agents of low and conventional doses in the CTA scan of pulmonary angiography, the quality of the images at the low dose of contrast agents can meet the clinical and imaging requirements.]]> 2018/7/30 16:15:14 LI Chuan, GUAN Xiao-hui, FAN Lan-zhen 156true ［Abstract］　Objective　To investigate the application value of a new cell block technique based on pre-gelatinized starch combined with immunohistochemistry in cytodiagnosis of dropsy of serous cavity. Methods　226 specimens of dropsy of serous cavity were collected. Traditional cell smears and cell blocks based on pre-gelatinized starch were made, and immunohistochemical staining was performed according to the diagnosis. Results　The positive rate of the traditional cell smears(11.06%) was significantly lower than that of the cell block combined with immunohistochemistry(21.24%)(P<0.05). Conclusion　The new cell block technique based on pre-gelatinized starch is simple in operation, good in slicing quality and good in immunohistochemical staining. Cell block combined with immunohistochemistry can improve the detection rate of malignant tumor cells and determine the source of metastatic tumors in dropsy of serous cavity.]]> 2018/7/30 16:15:14 CHEN Ji-qiong, HUANG Jia-qin, CAI Shu-ying, et al. 155true ［Abstract］　Objective　To explore the clinical effect of endoscopic resection of pituitary tumor by endoscopic sinus approach. Methods　From January 2015 to January 2016, the clinical effect of 19 patients with endoscopic sinus approach in our hospital were observed. Before surgery and 1 month after the treatment, NIHSS scores of the patients were recorded and their complications were observed. Results　One month after the surgery, the NIHSS scores of the patients(16±5) were significanthy higher than those before the operation(11±2)(P<0.05). A total of 5 cases occurred diabetes insipidus, including 4 cases of transient diabetes insipidus and 1 case of temporary diabetes insipidus. 2 cases occurred cerebrospinal rhinorrhea. 3 cases occurred electrolyte disorder and 1 case occurred pituitary secretion dysfunction. After the corresponding measures were taken, the complications were all improved, and there were no dead cases. Conclusion　During the operation of pituitary tumor resection by endoscopic sinus approach, it is clincally significant to follow the operation norms strictly, and to strengthen the prevention and treatment of postoperative complications.]]> 2018/7/30 16:15:15 QIN Zhen-yu, JIAN Guo-qing, YANG Jun 154true ［Abstract］　Objective　To explore the causes and preventive measures of failed operation on intracranial venous sinus injury. Methods　The clinical manifestations and treatment process of 23 cases with intracranial venous sinus injury were retrospectively analyzed. Results　According to the Glasgow Outcome Scale(GOS) scores, of the 23 cases, 11 cases had a good recovery, 3 cases had moderate disability, 2 cases had severe disability and 7 cases died. Conclusion　The operative treatment of intracranial venous sinus injury includes adequate preparation before operation and intraoperative control of massive hemorrhage which can achieve a satisfactory effect on intracranial venous sinus injury.]]> 2018/7/30 16:15:15 ZHONG Xiang-qiu, NING Jin-long 153true ［Abstract］　Objective　To explore the effects of delta-shaped anastomosis on digestive tract reconstruction after total laparoscopic gastric cancer radical resection. Methods　The patients with total laparoscopic gastric cancer radical resection in our hospital from January 2014 to January 2017 were screened according to the ratio of 1∶1, including 30 cases with delta-shaped anastomosis(the observation group) and 30 cases with Billroth type Ⅱ anastomosis(the control group). The general treatment conditions and the levels of nutritional indicators(total protein, albumin) were compared between the two groups before and after the operation. The effects of delta-shaped anastomosis on digestive tract reconstruction were observed. Results　There were no significant differences in the anastomosis time, intraoperative blood loss, exhaust time, the number of lymph node dissection, the proximal and distal incisal margin length of tumor, hospital stay and other general treatment conditions, and preoperative and postoperative nutritional indicators between the two groups(P>0.05). The number of postoperative analgesic drugs in the observation group was slightly less than that in the control group, and the nutritional indicators in the observation group before operation and 6 months after operation were lower than those in the control group(P<0.05). There was no significant difference in body mass index(BMI) between the two groups(P>0.05). The incidence rate of postoperative complications in the observation group was lightly lower than that in the control group(6.67% vs 13.33%)(P>0.05). Conclusion　Delta-shaped anastomosis is safe and effective for the patients with total laparoscopic gastric cancer radical resection. It can not only shorten the anastomosis time and reduce the postoperative pain, but also has a better long-term impact on nutritional status and BMI compared with BillrothⅡ anastomosis.]]> 2018/7/30 16:15:15 ZHAO Xiao-jun 152true ［Abstract］　Objective　To investigate the effects of breviscapine comined wih aspirin on the clinical symptoms and serum inflammatory factors in patients with acute ischemic cerebral infarction(AIS). Methods　96 patients with AIS in our hospital from September 2014 to September 2016 were enrolled in this study. They were divided into two groups according to the order of admission, with 48 cases in each group. Both of the two groups received the routine treatment for AIS. Besides, the control group was given aspirin, and the observation group was treated with breviscapine plus aspirin for 4 weeks. The clinical efficacy, serum inflammatory factors and the National Institutes of Health Stroke Scale(NIHSS) scores were compared between the two groups before and after treatment. Results　The total effective rate of the observation group was higher than that of the control group(P<0.05). After treatment, the serum levels of tumor necrosis factor alpha(TNF-alpha) and interleukin-6(IL-6) were decreased in both of the two groups compared with those before treatment, but the improvement of the observation group was better than that of the control group(P<0.01). After treatment, NIHSS scores of the observation group were lower than those of the control group(P<0.01). Conclusion　Breviscapine combined with aspirin can significantly improve the clinical symptoms and reduce the levels of serum inflammatory factors, and has remarkable clinical efficacy in the patients with AIS.]]> 2018/7/30 16:15:15 WANG Fu-jiu 151true ［Abstract］　Objective　To investigate the efficacy and safety of ticagrelor and clopidogrel in emergency percutaneous coronary intervention(PCI) for acute ST-segment elevation myocardial infarction(STEMI). Methods　100 STEMI patients treated with PCI were selected in the department of Cardiology of Jiuquan Municipal Hospital from January 2015 to August 2015. According to the random number table method, the patients were divided into two groups, with 50 cases in each group. Before PCI, the control group was given oral clopidogrel bisulfate tablets for treatment, and the observation group was given ticagrelor tablets. The platelet aggregation, stent thrombosis, the incidence of targeted restenosis, the incidence of adverse cardiovascular events, the incidence of postoperative bleeding, the incidence of adverse drug reactions and the proportion of Thrombolysis in Myocardial Infarction 3（TIMI3） were evaluated. Results　Before operation, the proportion of the patients with TIMI 3 in the two groups was equivalent(P>0.05). After operation, the proportion of TIMI 3 in the two groups increased significantly(P<0.05), but the observation group rose more than the control group(P<0.05). There was no significant difference in the incidence of thrombosis between the control group(6.00%) and the observation group(4.00%)(P>0.05). There was no significant difference in the incidence of targeted vascular restenosis between the observation group(2.00%) and the control group(6.0%)(P>0.05). There were no significant differences in the incidence rates of adverse cardiovascular events, postoperative bleeding and adverse drug reactions between the two groups(P>0.05). Conclusion　Compared with clopidogrel, ticagrelor can inhibit more rapidly platelet aggregation, reduce the incidence rates of targeted vascular restenosis, cardiovascular adverse events, postoperative bleeding and adverse drug reactions in emergency percutaneous coronary intervention for acute STEMI.]]> 2018/6/29 17:08:36 XI Yin-juan, LI Zhi-rong 150true ［Abstract］　Objective　To evaluate the effect of dexmedetomidine on intubation stress reactions under general anesthesia induction during noncardiac surgery in patients with coronary heart disease. Methods　Sixty ASA Ⅱ or Ⅲ patients with coronary heat disease were scheduled for elective upper abdominal surgery and were randomly divided into 2 groups: control group(n=30, group C) and dexmedetomidine group(n=30, group D). Dexmedetomidine 0.5 μg/kg was infused intravenously 10 min prior to anesthesia induction in group D, while the equal volume of normal saline was infused in group C. A1l the patients received the same anesthesia induction protocol. Tracheal intubation was performed when BIS value≤45. MAP, HR, NE and E were monitored and recorded at the time points of T₀, T₁(1 min before intubation), T₂(immediately before intubation), and T_3～5(1, 3 and 5 min after intubation). The adverse cardiovascular events were recorded during operation. Results　Compared with those at T₀, MAP and HR were significantly decreased in the two groups（P<0.05） and the levels of MAP, HR, NE and E were significantly higher in group C（P<0.05）. No significant changes were found in the above indexes in group D(P>0.05). Compared with those in group C, MAP was significantly higher（P<0.05） and MAP, HR, NE and E were significantly decreased in group D at T₁（P<0.05）, and the incidence rates of hypotension, hypertension and tachyeardia myocardial ischemia were significantly decreased（P<0.05）, and no significant changes were found in the incidence of bradyeardia between the two groups. Conclusion　Dexmedetomidine(0.5 μg/kg) infused intravenously can effectively inhibit the stress reactions caused by tracheal intubation and reduce the adverse cardiovascular events.]]> 2018/6/29 17:08:36 HE Qing-biao, WANG Yu-ming, HUANG Wei, et al. 149true ［Abstract］　Objective　To evaluate the clinical effect of laparoscopy combined with pelvic lymph node dissection on the treatment of cervical cancer. Methods　60 patients with cervical cancer treated in our hospital from January 2015 to January 2016 were divided into the observation group and the control group, with 30 cases in each group. The observation group was treated with laparoscopic radical hysterectomy combined with pelvic lymph node dissection. The control group was treated with open hysterectomy combined with pelvic lymph node dissection. The intraoperative condition, postoperative recovery, living ability and complications were compared between the two groups. Results　The operation and hospitalization time of the observation group was shorter than that of the control group. The intraoperative bleeding volume of the observation group was lesss than that of the control group(P<0.01). The time of postoperative intestinal function recovery, extubation and antibiotic use in the observation group was significantly shorter than that in the control group, but the urine tube removal time in the observation group was significantly longer than that in the control group. The incidence of complications in the observation group was lower than that in control group(P<0.05). The FACT-G scores of the observation group were higher than those of the control group 1 year after the surgery(P<0.01). Conclusion　Laparoscopy combined with pelvic lymph node dissection is safe and effective in the treatment of cervical cancer.]]> 2018/6/29 17:08:36 YANG Chang-xiang, GU Bao-shuang 148true ［Abstract］　Objective　To explore the therapeutic effect of plastic surgery combined with systematic rehabilitation on hand burns scar contracture deformity. Methods　80 patients with hand burns scar contracture deformity were randomly divided into the observation group(n=42) and the control group(n=38). The control group received plastic surgery combined with conventional functional exercise. The observation group received the same treatment as the control group plus systematic rehabilitation exercise. The total mobility of finger joints(TAM), daily life ability and the rate of good function of hands were compared between the two groups. Results　(1)The TAM values were significantly improved in both of the two groups after treatment. The improvement of the observation group was better than that of control group(P<0.01). (2)After 3 months, there were significant differences in the scores of washing face, dressing, eating and cutting finger nails in the observation group between pre and post treatment(P<0.05). However there were no significant differences in the above scores except for washing face in the control group between pre and post treatment(P>0.05). (3)The excellent and good rate of hand function in the observation group(88.1%) was significantly higher than that in the control group(65.8%) after a follow-up of 6 months(P<0.05). Conclusion　Plastic surgery combined with systematic rehabilitation is effective in the treatment of hand burns scar contracture deformity. It can significantly improve the mobility and flexibility of the hands.]]> 2018/6/29 17:08:36 ZHAO Shu-ying, LI Chang-ming 147true ［Abstract］　Objective　To compare the diagnostic value of Doppler ultrasound between abdominal examination and vaginal examination in scar pregnancy(CSP). Methods　58 cases of suspected CSP patients in our hospital during December 2015 and November 2017 were selected as the study subjects. All the patients received color Doppler ultrasound and abdominal and vaginal color Doppler ultrasound examination under the guidance of the physicians. The ultrasonic results were compared with the postoperative pathological results. The diagnostic sensitivity, specificity and coincidence rates were compared between the two examination methods of color Doppler ultrasound. Results　The diagnostic sensitivity and specificity rates of transvaginal sonography in diagnosis of uterine scar were higher than those of transabdominal ultrasound ultrasound（97.37% vs 81.58%, 95.00% vs 75.00%, P<0.05）. Of the 38 patients examined by abdominal color Doppler ultrasound, cystic echo, gestational sac, mixed echoes were detected in 31 cases, and the results were detected in 37 cases by transvaginal color Doppler ultrasound. The diagnostic coincidence rate of transvaginal color Doppler ultrasound examination was significantly higher than that of transabdominal color Doppler ultrasound examination(P<0.05). Conclusion　Transvaginal color Doppler ultrasonography has a higher diagnostic accuracy rate than transabdominal color Doppler ultrasound in diagnosis of CSP.]]> 2018/6/29 17:08:36 LIU Lan-yuan, CEN Bi-yu, MAI Ai-xin 146true ［Abstract］　Objective　To observe the effects of quadruple helicobacter pylori(Hp) eradication therapy on gastric emptying function and inflammatory factors in patients with duodenal ulcer(DU). Methods　84 DU patients treated in our hospital from February 2015 to July 2017 were selected, and they were divided into the control group and the observation group by random number table method, with 42 cases in each group. The control group was given omeprazole, amoxicillin, and clarithromycin, while the observation group was treated with quadruple Hp eradication therapy with omeprazole, amoxicillin, clarithromycin and colloidal bismuth pectin. The eradication rate of Hp infection, gastric emptying function and the levels of inflammatory factors were compared between the two groups. Results　The total effective rate and the eradication rate of the observation group were significantly higher than those of the control group(P<0.05). Before treatment, there were no significant differences in the gastric emptying time(T), antral contraction frequency(F), heat shock protein(HSP60) and tumour necrosis factor-α(TNF-α) between the two groups(P>0.05). After treatment, the levels of T, F, HSP60 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05). Conclusion　Quadruple therapy is effective in eradicating Hp, increasing gastric emptying function and down-regulating the levels of inflammatory factors for the patients with DU.]]> 2018/6/29 17:08:36 YANG Ying-dong 145true ［Abstract］　Objective　To investigate the changes of kidney size and renal cortex in women with pregnancy-induced hypertension by ultrasonography. Methods　600 pregnant women with normal pregnancy(normal pregnancy group, n=300) and pregnancy-induced hypertension(pregnancy-induced hypertension group, n=300) were enrolled in our hospital from March 2016 to March 2017. The size of kidney and the echo of renal cortex were analyzed by ultrasonography and the results were compared between the two groups. Results　There were some changes in the size, shape and renal cortex echo of the pregnant women with hypertension, and the kidney size of the pregnancy-induced hypertension group was smaller than that of the normal pregnancy group(P>0.05). Both renal morphological changes and renal cortical echo in the pregnancy-induced hypertension group were stronger than those in the normal pregnancy group(P<0.05). Conclusion　Ultrasound can accurately observe the renal size and renal cortical echo changes in the women with pregnancy-induced hypertension, which has a high diagnostic value in clinics.]]> 2018/6/29 17:08:36 SONG Wen 144true ［Abstract］　Objective　To explore the value of echocardiography for diagnosing Berry syndrome. Methods　The clinical and imaging data of 6 cases with Berry syndrome proved by surgery were retrospectively analyzed. Results　The ultrasonic diagnosis was fully consistent with the surgical results in 4 cases（66.7%）, partly in 2 cases（33.3%） including 1 case with aortic origin of the right pulmonary artery, and 1 cases with type A of interruption of aortic arch. Conclusion　Berry syndrome could be diagnosed accurately by echocardiography which is the first choice of preoperative diagnosis, postoperative reexamination and prognosis evaluation for the patients.]]> 2018/6/29 17:08:36 LUO Li, ZHAO Yi-lan, SHEN Jie, et al. 143true ［Abstract］　Objective　To analyze the effects of Xuebijing injection combined with ulinastatin on serum inflammatory factors in patients with severe acute pancreatitis. Methods　70 patients with severe acute pancreatitis in our hospital from September 2015 to April 2016 were selected as the research subjects and were divided into two groups by the random number table method, with 35 cases in each group. The control group received ulinastatin and the observation group was treated with ulinastatin plus Xuebijing injection. The serum levels of inflammatory cytokines and endotoxin were compared between the two groups before and 7days after treatment. Results　In the observation group,18 cases were cured,11 cases markedly effective, 4 cases effective and 2 cases ineffective. In the control group,12 cases were cured,10 cases markedly effective, 5 cases effective and 8 cases inffective. The clinical effect of the observation group was significantly better than that of the control group(P<0.05). Before treatment,there were no significant differences in the levels of serum inflammatory cytokines and endotoxin between the two groups(P>0.05). After treatment, the levels of hs-CRP, endotoxin, IL-6, IL-8 and TNF alpha in the control group were significantly higher than those in the observation group, but the level of IL-10 in the control group was significantly lower than that in the observation group(P<0.01). Conclusion　Xuebijing injection combined with ulinastatin is effective in the patients with severe acute pancreatitis, which can effectively elevate the level of IL-10 and reduce the levels of endotoxin, IL-6, IL-8 and TNF alpha.]]> 2018/6/29 17:08:36 ZHANG Jie-xian 142true ［Abstract］　Objective　To investigate the effect of atorvastatin combined with amlodipine on hypertension in elderly patients. Methods　From February 2015 to May 2016, 116 elderly patients with primary hypertension treated in our hospital were selected as the research subjects. The patients were divided into two groups according to the random number table, with 58 cases in each group. The control group was treated with amlodipine, and the observation group received atorvastatin plus amlodipine. The antihypertensive and lipid-reducing effects were compared between the two groups. Results　The levels of systolic blood pressure, diastolic blood pressure and blood lipids in the control group were significantly higher than those in the observation group 2, 4 and 6 months affer the treatment(P<0.05). Conclusion　Atorvastatin combined with amlodipine can effectively reduce the blood pressure and blood lipids in elderly patients with hypertension.]]> 2018/6/29 17:08:36 LU Su-pin 141true ［Abstract］　Objective　To evaluate the therapeutic effect of Shuganjieyu capsules combined with quadruple method on the treatment of helicobacter pylori(Hp) positive gastric ulcer.Methods　102 patients with positive gastric ulcer and Hp infection were selected as the research subjects. The patients were divided into two groups by random number table method: the quadruple group( using lansoprazole+colloidal pectin bismuth+clarithromycin+amoxicillin, n=51) and the Shugan group(using Shuganjieyu capsules+the quadruple treatment, n=51). Both of the two groups were treated for 6 weeks. The improvement of gastric function, the levels of gastrin(GAS) and motilin(MTL), and adverse reactions were compared between the two groups.Results　The clinical curative effect of the Shugan group was better than that of the control group(P<0.01). The improvements of the gastrointestinal scores, and the levels of GAS and MTL in the Shugan group were better than those in the quadruple group 10 d, 20 d and 30 d after treatment(P<0.05).Conclusion　Shuganjieyu capsules can improve the clinical effect of quadruple treatment on Hp-positive gastric ulcer.It is safe and can improve the gastrointestinal function, reduce the secretion of GAS and MTL in the patients.]]> 2018/5/30 8:21:22 ZHANG Yu 140true ［Abstract］　Objective　To explore the effects of different lipid-decreasing intensities on poststroke nerve function defect, blood lipid level and intima-media thickness of carotid artery.Methods　68 patients with acute cerebral infarction were randomly divided into the research group(n=34) and the control group(n=34). The research group was treated with atorvastatin calcium(40 mg, qd) for 3 months.The control group received calcium atorvastatin(20 mg, qd) for 3 months. NIHSS scores and the data of serum lipid level were collected before and after treatment. Intima-media thickness of carotid artery was detected by TCD method.Results　There were no significant differences in NIHSS scores between the research group and the control group before and 3 months after treatment. After treatment, TC, LDL-C and the intima-media thickness of carotid artery in the research group were significantly lower than those in the control group. However, there were no significant differences in TG and HDL-C between the two groups.Conclusion　Large dose of atorvastatin(40 mg) can decrease TC and LDL-C, stabilize internal carotid artery plaque, and reduce intima-media thickness of carotid artery on a larger scale than small dose of atorvastatin(20 mg).]]> 2018/5/30 8:21:22 WU Chuan-xi, LIN Jin-hua 139true ［Abstract］　Objective　To compare the anti-rotation intramedullary nail of proximal femur(proximal femoral nail anti-rotation, PFNA) and locking plate fixation (proximal femur locking plate, PFLP) in treatment of femoral intertrochanteric fractures.Methods　From June 2014 to August 2016, 110 patients with femoral intertrochanteric fractures were collected in our hospital and were divided into two groups, with 55 cases in each group. The PFNA group was treated with PFNA and the PFLP group was treated with PFLP. The surgical indicators and hip function were compared between the two groups.Results　There was no significant difference in the hip function between the two groups（P>0.05）. Compared with those in the PFLP group,the incision length was shorter, the intraoperative blood loss and loss of Hb were less and the healing time was shorter in the PFNA group(P<0.01).Conclusion　Both of PFNA and PFLP are an effective treatment of intertrochanteric fractures. PFNA is minimally invasive surgery, and can significantly reduce the incision length and trauma, and alleviate the pain.]]> 2018/5/30 8:21:22 WANG Wei-jun 138true ［Abstract］　Objective　To observe the clinical effect of posterior lateral access plate internal fixation in treatment of posterior malleolar fractures.Methods　36 patients with posterior malleolus fractures from March 2015 to March 2017 in our hospital were selected. All the patients received posterior lateral access plate fixation for treatment. The clinical efficacy, adverse events and other related indicators were observed.Results　The average operative time was (80.10±20.07)min and the average intraoperative blood loss was (119.60±80.06)ml. After operation, all the fractures healed and the average healing time was (89.10±10.62)d. The excellent rate of ankle function was 88.89%. Ankle function was excellent in 22 cases, good in 10 cases, fair in 4 cases and poor in 0 case. During the follow-up period, 2 cases(5.56%) had incision infection, 1 case(2.78%) had delayed union of fractures and adverse events such as loosening of the internal fixation, skin necrosis at the edge of the incision and displacement of the fractures.Conclusion　For the patients with posterior malleolus fractures, posterior lateral access plate fixation has a certain clinical effect. It can effectively improve the patients′ ankle function, and reduce the adverse events such as postoperative wound infection and the safety of the operation is relatively high.]]> 2018/5/30 8:21:22 LI Ming-xi 137true ［Abstract］　Objective　To evaluate the clinical effect of percutaneous via hepatic gallbladder puncture colostomy on elderly patients with severe calculous cholecystitis.Methods　84 elderly patients with severe calculous cholecystitis were collected in our hospital from July 2015 to July 2016 and were randomly divided into the observation group(n=42) and the control group(n=42). The control group received laparoscopic cholecystectomy,and the observation group was treated with percutaneous via hepatic gallbladder puncture colostomy. The intraoperative and postoperative clinical data and complications were compared between the two groups. Results　Compared with those in the control group, the operation time,the length of hospital stay and time of body temperature recovery, white blood cells and blood coagulation function recovering to the normal levels, and the time of shock disappearing in the observation group were significantly shorter(P<0.01). The postoperative complication rate of the control group was higher than that of the observation group(P<0.01).Conclusion　Percutaneous via hepatic gallbladder puncture colostomy is better than laparoscopic cholecystectomy in treatment for the elderly patients with severe calculous cholecystitis.]]> 2018/5/30 8:21:22 GAO Yang, HUANG Xin-li, XING Hua-wei 136true ［Abstract］　Objective　To compare the clinical outcomes of percutaneous fixation and closed reduction external fixation in the treatment of proximal humerus epiphyseal separation in children.Methods　The clinical data of 48 children with fractures of proximal humerus epiphyseal separation were retrospectively analyzed, among whom group A was treated with percutaneous fixation(n=24), and group B was treated with closed reduction and external fixation(n=24). The clinical effects and complications were compared between the two groups.Results　All the patients were followed up. According to the Flynn score evaluation, the Flynn scores of shoulder and elbow joint function in group A(85.35±11.85) were significantly higher than those in group B(74.16±10.12)(P<0.05). According to the preoperative and postoperative shoulder joint abduction angle evaluations, group A was (171.4±5.4)degrees, and group B was (152.8±6.1)degrees, with a significant difference in the excellent and good rate between the two groups(P<0.05).Conclusion　The percutaneous fixation can improve the proximal humerus epiphyseal separation of the shoulder and elbow outreach angle better and has a better long-term prognosis and clinical application than the closed reduction external fixation.]]> 2018/5/30 8:21:22 YE Hua-bao, SUN Ke, XIONG Chun-xiang, et al. 135true ［Abstract］　Objective　To investigate the effect of QCC(quality control circles) PDCA(plan-do-check-action cycle) management on the quality of routine paraffin sections.Methods　The quality control of routine paraffin sections of the placenta was carried out using the QCC PDCA management model to analyze its effect on the quality of the conventional paraffin sections of the placenta.Results　The grade A section percentage of the observation group(97.40%) was significantly higher than that of the control group(87.11%)（P<0.05）.Conclusion　The QCC PDCA management model can effectively improve the percentage of grade-A sections of placental paraffin sections and has a good effect on improving the quality of pathological diagnosis.]]> 2018/5/30 8:21:22 HE Yue-sheng, LIU Wen-ke, HU Hui-zhen, et al. 134true ［Abstract］　Objective　To investigate the clinical application of VSD technique combined with free groin flap transplantation in treatment of necrotic wounds after snakebite at upper limbs.Methods　Debridement and VSD continuous irrigation and negative pressure were performed on the patients with skin necrosis after snakebite at upper limbs, then free groin flaps were transplanted to repair the wounds. The sizes of free flaps were 8 cm×13 cm to 14 cm×19 cm.Results　Of the 17 cases performed skin transplantation, 2 cases had partial necrosis and their wounds healed gradually after local dressing, the rest 15 cases had completely successful operation with satisfying flap appearance and texture, and well recovered limb function.Conclusion　VSD technique combined with free groin flap transplantation is an ideal method of treatment for necrotic wounds after snakebite at upper limbs.]]> 2018/5/30 8:21:22 WEI Li-yong, WEI Ren-jie, HUANG Da-bo, et al. 133true ［Abstract］　Objective　To study the imaging manifestations of high resolution CT(HRCT) in patients with systemic sclerosis（SSc）.Methods　The imaging manifestations of HRCT in 15 patients with clinically diagnosed SSc were analyzed retrospectively.Results　The lungs were normal in 4 cases and had interstitial fibrosis with peripheral distribution in 11 cases. HRCT was mainly manifested in distortions of the bronchovascular bundles and the thickening of the interlobular septum, strips, inferior pleural lines and the curved lines in 9 cases, and in a grid change in 7 cases. Small nodules were distributed along the bronchial vascular bundles and lobular septum, and small nodules under the pleura in 10 cases. Simple grinding glass change was found in 5 cases. Mild pleural thickening or a small amount of pleural effusion was found in 9 cases. Small flaky solid and honeycomb lungs were found in 4 cases.Conclusion　HRCT shows the minute structure changes of interstitial lung disease in SSc, which is of great value in the diagnosis and follow-up treatment for SSc.]]> 2018/5/30 8:21:23 WEI Hong-xing, MA Shu-huan, FENG Qiu-hua 132true ［Abstract］　Objective　To investigate the clinical diagnostic value of high frequency 2D and 3D color Doppler ultrasound combined with mammagraphy in diagnosis of breast carcinoma.Methods　59 patients with breast carcinoma were chosen and their clinical data were retrospectively analyzed to calculate the rate of conformity in clinical diagnosis with high frequency color Doppler ultrasound combined with X-ray mammography.Results　The positive diagnosis rates of breast cancer were 87.74% and 76.27% using color Doppler ultrasound and X-ray mammography respectively, which were significantly lower than that using the combined diagnosis with color Doppler ultrasound and mammagraphy(93.22%)(P<0.05).Conclusion　The diagnosis rate of high frequency color Doppler ultrasound in combination with X-ray mammography is significantly elevated for diagnosing breast cancer.]]> 2018/5/30 8:21:23 XI Jian-wu, JIN Qiu-long, CAO Yang 131true ［Abstract］　Objective　To analyze the clinical effect of fixed orthodontic technique on the fixation of traumatic permanent teeth.Methods　76 cases with permanent anterior teeth trauma admitted and treated in our department in last two years were retrospectively analyzed. They were divided into the control group and the observation group in accordance with the different treatment methods, with 38 cases in each group. The observation group received the fixed orthodontic technique of fixing trauma for the loose permanent anterior teeth. The control group received the flat steel wire resin splint for the loose permanent anterior teeth trauma. The clinical curative effect was compared between the two groups.Results　There were no significant differences in the decline of tooth mobility degree between the two groups after treatment(P>0.05). There were no significant differences in dental plague index(PLI) and gingival index(GI) between the two groups before treatment(P>0.05). After treatment, the PLI and GI in the observation group were significantly lower than those in the control group. In the control group, the GI was significantly higher after treatment（P<0.05）. There was no significant difference in periodontal index in the observation group before and after treatment(P>0.05).Conclusion　The flat steel wire resin splint fixation of traumatic loose permanent anterior teeth has no obvious effect on periodontal index, but has high cleanliness and good clinical curative effect.]]> 2018/4/27 7:59:26 ZHAO Hai-qiang, ZHANG Dong-xiao 130true ［Abstract］　Objective　To investigate the relationship between cervical lesions and cervical papillomavirus(HPV) subtypes in Huangshi area, and to provide the data for cervical cancer prevention and development of cervical HPV vaccine.Methods　6 500 cases of cervical cancer screening were selected in Huangshi Maternity and Child Healthcare Hospital, and the results were compared with TCT, colposcopy and cervical biopsy.Results　The positive rate of HPV infection was 25.23%; According to the pathological test results, the positive infection rates of HPV chronic cervicitis,cervical intraepithelial neoplasia(CIN)gradeⅠ, CINⅡ/Ⅲ and cervical cancer were 37.50%, 60.00%, 83.33% and 100.00% respectively.High-risk HPV42(33.87%), high-risk HPV52(14.52%), low-risk HPV43(6.45%) and low-risk HPV42(6.45%) were the highest percentage, while a single infection accounted for 79.55%. The HPV infection rate at the age≤30 years was 40.28%.Conclusion　High-risk HPV16, 52 and low-risk HPV43, 42 are the common subtypes in cervical lesions in Huangshi area. With increase in cervical lesions, the positive infection rate of cervical HPV also increases, which is primarily in a single infection. Cervical HPV infection becomes an increasingly younger trend.]]> 2018/4/27 7:59:26 HU Jing, LU Na 129true ［Abstract］　Objective　To study the role of bone age analysis in clinical practice by comparing the bone age with actual age in children and adolescents. Methods　The X-ray films of the left wrist cartilage were analyzed by TW3-C RUS and TW3-C Carpal method in 92 children and adolescents.Results　In the female children(40 cases), the bone age was greater than the actual age in 15 cases(37.5%), the bone age equal to the actual age in 2 cases(5.0%), and the bone age lower than the actual age in 23 cases(57.5%). Combining the physical examination and the laboratory examination findings, we found precocious puberty in 1 case, hyperthyroidism in 1 case, growth hormone deficiency in 1 case, physical development and adolescent delay in 1 case and subclinical hypothyroidism in 1 case. In the male children(52 cases), the bone age was greater than actual age in 18 cases(34.6%), the bone age equal to the actual age in 5 cases(9.6%), the bone age lower than the actual age in 29 cases(55.8%). Combining the physical examination and the laboratory examination findings, we found familial short stature in 5 cases, hyperthyroidism in 1 case, precocious puberty in 1 case, physical development and adolescent delay in 2 cases, less than gestational age in 2 cases, growth hormone deficiency in 1 case and hypothyroidism in 1 case.Conclusion　Combining analysis of bone age and physical examination and laboratory examination can help to discover the causes affecting the children and adolescents′ growth and development, and help doctors take intervention measures timely in clinical practice.]]> 2018/4/27 7:59:26 DENG Rong, LI Ying, HUANG Ren 128true ［Abstract］　Objective　To analyze the efficacy and safety of butylphthalide combined with naloxone in treatment of posterior circulation ischemic vertigo in elderly patients.Methods　120 elderly patients with posterior circulation ischemic vertigo were divided into the study group(n=60) and the control group(n=60) by random number table method. The study group was treated with butylphthalide and naloxone. The control group was treated with conventional medications. All the patients were treated for 2 weeks. The clinical efficacy and safety were compared between the two groups.Results　The values of Vm and Vs of the basilar artery, left vertebral artery and right vertebral artery in the study group improved better than those in the control group(P<0.05). The clinical efficacy of the study group was excellent in 23 cases, good in 18 cases, medium in 14 cases and poor in 5 cases. The clinical efficacy of the control group was excellent in 15 cases, good in 13 cases, medium in 13 cases and poor in 19 cases. The clinical efficacy of the study group was better than that of the control group(P<0.01).Conclusion　Butylphthalide combined with naloxone has a significant clinical effect on posterior circulation ischemic vertigo in the elderly patients. It can effectively alleviate the symptoms of vertigo, improve the posterior circulation and promote the recovery at an early stage.]]> 2018/4/27 7:59:26 YUE Lei, ZHANG Wen-hui 127true ［Abstract］　Objective　To investigate the effect of different blood flow blocking protocols on primary hepatocellular carcinoma, and to provide the reference for the choice of optimal blood flow interruption during hepatectomy.Methods　Seventy-eight hepatocellular carcinoma patients who underwent open hepatectomy from June 2010 to June 2017 in our hospital were enrolled. The patients were divided into two groups according to the different intraoperative hepatic blood occlusions: group A(hemihepatic vascular occlusion, n=40) and group B(pringle maneuver occlusion, n=38). The operation time, intraoperative blood loss, intraoperative blood flow interruption time, serum level of alanine aminotransferase and early postoperative complications were compared between the two groups.Results　There were no significant differences between group A and group B in the median operative time(160.5 vs 155.3 minutes), the median blood loss(498.2 vs 512.0 ml) and the median occlusion time(33.7 vs 31.6 minutes)(P>0.05). The levels of alanine aminotransferase in group A on the first, third and seventh day after operation were significantly lower than those in group B(P<0.05). In group A, the postoperative complications occurred in 5 cases(12.5%), including 1 case with biliary fistula, 1 case with liver section hemorrhage, 2 cases with pleural effusion and 1 case with incision infection. In group B, the postoperative complications occurred in 8 cases(21.1%), including 2 cases with biliary fistula, 3 cases with pleural effusion and 3 cases with ascites. There was a significant difference in the incidence of early postoperative complications between the two groups(P<0.05).Conclusion　Compared with Pringle maneuver occlussion, hemihepatic vascular occlussion can reduce the damage of postoperative liver function and reduce the complications in the patients with primary hepatocellular carcinoma. Hemihepatic vascular occlusion is a safe and effective blood flow control method in hepatectomy.]]> 2018/4/27 7:59:26 HUANG Xiao-ting, CHEN Yuan-lei, HE Wei-hai, et al. 126true ［Abstract］　Objective　To investigate the clinical effect of amoxicillin clavulanate tablets on the treatment of acute pharyngeal tonsillitis.Methods　A total of 110 patients with acute pharyngeal tonsillitis were enrolled in this study from July 2015 to June 2017. The patients were divided into two groups according to random number table. The patients in the control group were treated with amoxicillin for suspension. The patients in the observation group were treated with amoxicillin and clavulanate tablets. Both of the two groups were treated for 10 days(5 days for a treatment course). The clinical therapeutic effects of the two groups were compared and evaluated.Results　In the observation group, 25 cases were cured, 20 cases markedly improved, 7 cases effective and 3 cases ineffective; In the control group, 10 cases were cured, 22 cases markedly improved, 12 cases effective and 11 cases ineffective. The clinical curative effect of the observation group was significantly higher than that of the control group(P<0.01). The remission time of the clinical symptoms in the observation group was significantly shorter than that in the control group(P<0.01). There was no significant different in the incidence of adverse reactions between the treatment group(3.64%) and the control group(7.28%)(P>0.05).Conclusion　Amoxicillin and clavulanate tablets are more effective than amoxicillin for suspension in the treatment of acute pharyngeal tonsillitis. Amoxicillin and clavulanate tablets can shorten the time of clinical symptoms remission and improve the clinical treatment efficiency, and its safety is relatively high.]]> 2018/4/27 7:59:26 LING Yu-gao 125true ［Abstract］　Objective　To study the effect of sentinel lymph node biopsy on postoperative immune function and prognosis in patients with early breast cancer.Methods　90 patients with early breast cancer in our hospital from February 2015 to July 2016 were selected and divided into two groups according to the different treatment methods, with 45 cases in each group. The patients in the observation group were treated with sentinel lymph node biopsy, and axillary lymph node dissection was performed for the patients in the control group. The postoperative immune function and shoulder function were compared between the two groups.Results　There were no significant differences in the levels of CD8⁺ and CD4⁺ between the two groups before operation(P>0.05). The level of CD4⁺ in the observation group was significantly higher than that in the control group, while the level of CD8⁺ in the observation group was lower than that in the control group(P<0.05). The excellent and good rate of shoulder joint function in the observation group was significantly higher than that in the control group(P<0.05).Conclusion　Sentinel lymph node biopsy can effectively improve postoperative immune function and shoulder function for the patients with early breast cancer.]]> 2018/3/28 17:03:21 ZHANG Yu-feng 124true ［Abstract］　Objective　To evaluate the efficacy of noninvasive ventilation in treatment of acute heart failure.Methods　From March 2015 to March 2017, 100 patients with acute heart failure were selected in our hospital, and were randomly divided into the control group and the treatment group,with 50 cases in each group. The control group received the routine treatment, including oxygen inhalation, sedation, vasodilator, diuretic, maintaining electrolyte balance and correction of acid and alkali disorders. The treatment group received early noninvasive ventilation therapy plus the same routine treatment as the control group. The clinical efficacy, the rate of endotracheal intubation, respiratory rate(RR), heart rate(HR) and blood gas levels(PaO₂, PaCO₂) were compared between the two groups.Results　After treatment, the effective rate of the treatment group was significantly higher than that of the control group(P<0.05), while the rate of endotracheal intubation in the treatment group was significantly lower than that in the control group(P<0.05). The improvements of HR, RR, and the levels of PaO₂ and PaCO₂ in the treatment group were better than those in the control group(P<0.05).Conclusion　Early noninvasive ventilation therapy plus the routine treatment can significantly improve the clinical efficiency, reduce the rate of endotracheal intubation and improve the symptoms in the patients with acute heart failure.]]> 2018/3/28 17:03:21 HUANG Jian-hui, LUO Yan, LIN Li-qun, et al. 123true ［Abstract］　Objective　To investigate the clinical efficacy and adverse reaction of lansoprazole combined with flupenthixol melitracen in treatment of functional dyspepsia.Methods　120 cases with functional dyspepsia in our hospital were divided into the control group(n=60) and the observation group(n=60) by the random number table method. The control group was given lansoprazole for treatment, while the observation group received lansoprazole combined with flupenthixol melitrace. The clinical efficacy and adverse reations were compared between the two groups.Results　After treatment, the clinical effect of the observation group was markedly effective in 53 cases, effective in 6 cases and ineffective in 1 case, and that of the control group was markedly in 42 cases, effective in 13 cases and ineffective in 5 cases. The clinical effect of the observation group was better than that of the control group(P<0.05). The scores of functional dyspepsia questionnaire and Hamilton anxiety scale after treatment were lower than those before treatment in both of the two groups(P<0.05). After treatment, the scores of functional dyspepsia questionnaire and Hamilton anxiety scale in the observation group were signigicantly lower than those in the control group(P<0.05).Conclusion　Lansoprazole combined with flupenthixol melitracen has better clinical effect and less adverse reactions in treatment of functional dyspepsia.]]> 2018/3/28 17:03:21 SONG Li-ming 122true ［Abstract］　Objective　To investigate the effect of homocysteine(Hcy), high sensitive C reactive protein(hs-CRP) and serum lipid on the patients with cerebrovascular diseases.Methods　60 patients with cerebrovascular diseases in our hospital were collected as the observation group, and 60 healthy people were taken as the control group. Hcy, hs-CRP and serum lipid were detected and compared between the two groups.Results　The improvements of Hcy, hs-CRP, HDL-C and LP(a) in the observation group were better than those in the control group(P<0. 05).Conclusion　The detections of Hcy, hs-CRP and blood lipid have clinical value for the diagnosis and treatment of cerebral vascular diseases.]]> 2018/3/28 17:03:21 LIU Jian-qiang 121true ［Abstract］　Objective　To explore the clinical effect of the treatment of hypertensive intracerebral hemorrhage by microsurgery through lateral fissure insular approach.Methods　90 patients with hypertensive cerebral hemorrhage in our hospital from June 2015 to August 2016 were selected. All the patients were randomly divided into two groups according to the random number table method, with 45 cases in each group. The control group was treated with conventional craniotomy, while the observation group was treated with lateral fissure insular approach microsurgery. The hematoma clearance rate, preoperative and postoperative living ability and coma score, adverse reaction rate were compared between the two groups.Results　The hematoma clearance rate of the observation group was significantly higher than that of the control group(P<0.05). After operation, the life ability and the degree of coma score in the observation group improved better than those in the control group(P<0.05). The incidence of adverse reactions in the observation group(6.67%) was significantly lower than that in the control group(24.44%)(P<0.05).Conclusion　Minimally invasive surgery by lateral fissure insular approach is effective in treatment of hypertensive intracerebral hemorrhage.]]> 2018/3/28 17:03:21 WANG Yong-feng 120true ［Abstract］　Objective　To explore the clinical value of transcutaneous carbon dioxide（TcPCO₂） and transcutaneous oxygen（TcPO₂） monitoring on critically ill neonates, especially those in need of respiratory support.Methods　The critically ill neonates who needed respiratory support in the neonatal intensive care unit between April 1, 2016 and March 31, 2017 were selected,and their continuous TcPCO₂ and TcPO₂ monitoring was performed. The results of TcPCO₂ and TcPO₂ measurements were compared with those of arterial carbon dioxide partial pressure(PaCO₂) and arterial oxygen partial pressure(PaO₂).Results　A total of 44 neonates were included and 188 sets of data were collected. Pearson′s product-moment correlation showed that there was a good correlation between TcPCO₂ and PaCO₂, TcPO₂ and PaO₂. Pearson coefficient was 0.886 for TcPCO₂ and PaCO₂, and 0.676 for TcPO₂ and PaO₂, P<0.005.Conclusion　TcPCO₂ and TcPO₂ monitoring provides more accurate estimate of PaCO₂ and PaO₂ for critically ill neonates, especially PaCO₂. The use of continuous TcPCO₂ and TcPO₂ monitoring can reduce the number of blood collection and painful stimulus for critically ill neonates.]]> 2018/3/28 17:03:21 CAI Lin, LI Xiao-dong, LIU Li-fang, et al. 119true ［Abstract］　Objective　To observe the clinical efficacy of valacyclovir hydrochloride granules combined with Shuanghuanglian oral solution in treatment of varicella in children.Methods　86 children with varicella treated from May 2016 to April 2017 were randomly divided into the control group and the observation group, with 43 cases in each group. The control group was treated with valacyclovir hydrochloride granules, 5～10 mg/ kg·d, bid. The observation group was treated with the same treatment as the control group plus Shuanghuanglian oral liquid 10 ml, tid(1～3 years old), 20 ml, tid(4～7 years old). Both of the two groups were treated for 3 days. The symptom improvement time, clinical efficacy and adverse reactions were compared between the two groups.Results　In the observation group, 20 cases were markedly effective, 19 effective, and 4 ineffective. In the control group, the clinical outcome was markedly effective in 9 cases, effective in 27 cases, and ineffective in 7 cases. The curative effect of the observation group was better than that of the control group(P<0.05). The disappearance time of clinical symptoms was significantly shorter than that of the control group（P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion　Valacyclovir hydrochloride granule combined with Shuanghuanglian oral solution is effective in treatment of varicella in children. It can shorten the time for symptom improvement.]]> 2018/3/28 17:03:21 WANG Ling-yan 118true ［Abstract］　Objective　To compare the clinical effect of tunnel thread drawing and multi-incision thread drawing drainage on the treatment of high horseshoe anal abscess.Methods　From December 2014 to December 2015, 88 patients with high horseshoe anal abscess were divided into two groups according to different surgical methods, with 44 cases in each group. The control group was treated with multi-incision thread drawing drainage, while the observation group was treated with tunnel type wire drawing. The operative effect, postoperative recovery time and anal recovery were compared between the two groups.Results　There was no signficant difference in the operative effect between the two groups(P>0.05). The postoperative recovery time of the observation group was significantly shorter than that of the control group and the anal function of the observation group improved better than that of the control group(P<0.05).Conclusion　The tunnel thread drawing technique is a safe and effective method for the treatment of high horseshoe anal abscess.]]> 2018/3/28 17:03:21 YANG You-zhi 117true ［Abstract］　Objective　To investigate the clinical effect of Bard 3 Dmax mesh in totally extraperitoneal prosthetic(TEP) on inguinal hernias.Methods　136 patients with inguinal hernia were randomly divided into the observation group(n=69) and the control group(n=67). The observation group was treated with Bard 3 Dmax mesh in TEP, and the control group was treated with traditional hemioplasty. The operation time, intraoperative bleeding, off-bed activities after the operation, use of analgesics, length of hospital stay, average hospitalization expenses, complications and recurrence rates were compared between the two groups.Results　The operation time was longer and the average hospitalization expenses was more in the observation group than those in the control group(P<0.05). But the intraoperative bleeding, off-bed activities after operation, length of hospital stay and use of analgesics in the observation group were less than those in the control group(P<0.05). The postoperative complication rate of the observation group was lower than that of the control group(P<0.05). There was no significant difference in the recurrence rate between the two groups(P>0.05).Conclusion　Bard 3 Dmax mesh in TEP has a significant curative effect on inguinal hernias.]]> 2018/3/28 17:03:21 LU Xu-xin 116true ［Abstract］　Objective　To explore the operation efficacy and safety of endoscopic retrograde cholangiopancreatography combined with laparoscopic in treatment of common bile duct stones with gallstones, and to detect the levels of serum total bilirubin(TBIL), urinary trypsinogen-2 and CRP.Methods　138 patients with common bile duct stones with gallstones were selected in our hospital from October 2016 to February 2017, and were randomly divided into the control group(n=69) and the study group(n=69). The patients in the control group were treated with open cholecystectomy and the patients in the study group received endoscopic retrograde cholangiopancreatography combined with laparoscopic surgery. The surgical conditions, clinical efficacy and postoperative adverse reactions, and the levels of postoperative TBIL, urinary trypsinogen-2 and CRP were observed and compared between the two groups.Results　The average incision size, intraoperative blood loss, operation time, postoperative exhaust time and hospital stay time in the study group were superior to those in the control group［(2.86±0.79) vs (6.92±1.03)cm, (42.33±9.86) vs (75.21±10.17)ml, (71.73±10.24) vs (98.46 ± 11.58)min, (18.93±2.54) vs (27.61±2.85)h and (9.47±1.65) vs (14.39±2.07)d］(P<0.01). The rate of using analgesics in the study group(13.04%) was significantly lower than that in the control group(63.77%)(P<0.01). There were no significant differences in the incidence rates of postoperative complications and residual stone between the two groups(P>0.05). The levels of TBIL, urinary trypsinogen-2 and CRP in the study group were significant lower than those in the control group［（62.40±18.37） vs (74.56±16.28)μmol/L, （30.61±6.44） vs (36.98±7.35)ng/ml and （247.39±26.15） vs (316.74±29.61) mg/L］(P<0.01).Conclusion　Endoscopic retrograde cholangiopancreatography combined with laparoscopic is effective in treatment of common bile duct stones with gallstones. It can effectively remove the stones, and has the advantages of less trauma and faster recovery.]]> 2018/3/2 17:10:11 HE Feng, XING Cheng, FENG Shi-lin, et al. 115true ［Abstract］　Objective　To evaluate the clinical effect of holmium laser lithotripsy on treatment of ureteral calculi.Methods　200 patients with ureteral calculi were collected in our hospital from October 2015 to November 2016 and were randomly divided into the treatment group(n=116) and the control group(n=84). The treatment group(135 sides) was treated with holmium laser lithotripsy via ureteroscopy, while the control group(96 sides) was treated with pneumatic ballistic lithotripsy. The treatment effect was compared between the two groups.Results　The success rate of lithotripsy of the treatment group(97.04%) was significantly higher than that of the control group(87.50%)(P<0.05). After a follow-up of one month, the stone clearance rate of the treatment group(97.71%) was significantly higher than that of the control group(91.67%)(P<0.05). There were no significant differences in the incidences rates of complications between the two groups(P>0.05).Conclusion　Holmium laser lithotripsy via ureteroscopy is safe and effective for the patients with ureteral calculi.]]> 2018/3/2 17:10:11 HUANG Jing-zhi 114true ［Abstract］　Objective　To explore the clinical effect of laparoscopic hiatal hernia repair and fundoplication on the treatment of esophageal hiatal hernia and gastroesophageal reflux.Methods　80 patients with hiatal hernia complicated with gastroesophageal reflux were collected in our hospital from February 2015 to April 2016 and were randomly divided into two groups, with 40 cases in each group. The control group was treated with conventional laparotomy, while the observation group was treated with laparoscopic hiatal hernia repair and fundoplication. The operation parameters, quality of life, complications and postoperative condition were compared between the two groups.Results　The amount of bleeding, gastrointestinal function recovery time, operation time and hospitalization time in the observation group were less than those in the control group(P<0.01). The chest pain, heartburn, acid regurgitation scores in the observation group were lower than those in the control group(P<0.01). The GLQI scores of the observation group increased higher than those of the control group(P<0.01). The complication rate of the observation group was significantly lower than that of the control group(P<0.05).Conclusion　Laparoscopic hiatal hernia repair combined with fundoplication treatment can effectively optimize the operation indexes, improve the patients′ conditions, and their quality of life and reduce the incidence of postoperative complications in the treatment of esophageal hiatal hernia complicated with gastroesophageal reflux.]]> 2018/3/2 17:10:11 WANG Chun-xiao 113true ［Abstract］　Objective　To evaluate the clinical value of 128 slice spiral CT coronary angiography(CTA) in the diagnosis of myocardial bridge(MB) and its related coronary artery disease.Methods　The clinical data and coronary CTA images of 300 cases in our hospital from January 2015 to December 2015 were analyzed to evaluate the detection rate and the thickness of the MB, degree of mural coronary artery(MCA) stenosis and coronary atherosclerotic plaque related MB.Results　MB-MCA was found in 92 cases(107 parts), with the thickness of the deep type of MB-MCA being about （3.15±1.12）mm. During diastole, mild stenosis of MCA occurred in 22 cases and moderate stenosis in 8 cases. During systolic, mild stenosis of MCA occurred in 75 cases, moderate stenosis in 15 cases and severe stenosis in 6 cases. The proximal coronary artery atherosclerotic plaques were found in 46 cases of 107 affected parts, of which mild stenosis of proximal vascular lumen occurred in 37 cases, moderate stenosis in 6 cases and severe stenosis in 3 cases.Conclusion　128 slice spiral CT coronary artery imaging is non-invasive and can accurately measure the thickness of MB, evaluate MCA stenosis with the multi-stage reconstruction, analyze the coronary atherosclerotic plaques related to MB, and provide more information for clinical examination and treatment.]]> 2018/3/2 17:10:11 ZHU Li-li, ZHENG Yu-fei, XU Hui, et al. 112true ［Abstract］　Objective　To investigate the effect of painless labor caused by epidural anesthesia on the duration of labor in primiparas and the prognosis of the neonatal outcome.Methods　90 primiparas receiving delivery in our hospital from August 2015 to May 2016 were selected as the research subjects and were randomly divided into two groups, with 45 cases in each group. The control group did not use any analgesic measures, while the observation group received epidural anesthesia for painless delivery. The analgesic effect, the duration of labor and the Apgar scores of neonates were compared between the two groups.Results　The analgesic effect of the observation group was significantly better than that of the control group(P<0.01). The time for the first and the second stages of labor in the observation group was shorter than that in the control group. The Apgar scores of the observation group were higher than those of the control group(P<0.01). There was no significnthy difference in the third labor time between the two groups(P>0.05).Conclusion　Epidural anesthesia is safe and effectively shortens the duration of labor, reduces the neonatal asphyxia or intrauterine hypoxia and improves the Apgar scores and the birth outcomes for the primiparas.]]> 2018/3/2 17:10:11 GUO De-sheng 111true ［Abstract］　Objective　To observe the curative effect of sodium phosphocreatine on rotavirus enteritis complicated with myocardial damage in children.Methods　80 children with rotavirus enteritis complicated with myocardial damage treated in our hospital from 2014 to 2016 were randomly divided into the control group(n=40) and the observation group(n=40). Fluid infusion, correction of acidosis, water electrolyte disorder and antiinfection were given to the two groups. Besides the above routine treatments in the two group, the observation group was treated with sodium phosphocreatine, 1 g+0.9% sodium chloride, intravenous drip, once daily, 7 days for a treatment course.Results　After the treatment, myocardial enzyme CK-MB, LDH-1 and HBDH were (44.5±12.3)U/L and (180.2±13.8)U/L and (255.46±63.22)U/L in the control group respectively, and (32.3±6.7)U/L, (115.6±11.7)U/L and (220.31±36.53)U/L in the observation group respectively. The recovery rate of electrocardiogram was 75.0% in the control group and 92.5% in the observation group. The level of cardiac troponin was (0.11±0.03)U/L in the control group and (0.05±0.01)U/L in the observation group. The treatment was more effective in the observation group than that in the control group(P<0.05).Conclusion　Injection of sodium phosphocreatine is effective for the children with rotavirus enteritis complicated with myocardial damage.]]> 2018/3/2 17:10:11 MO Yan 110true ［Abstract］　Objective　To explore the atypical molybdenum X-ray manifestations of breast cancer and to improve its diagnosis rate.Methods　The X-ray images of 98 patients with breast cancer and pathological results were collected and their characteristics were analyzed and summarized, and the comprehensive analysis was made by combing the pathological results, age and mammary backgrounds together.Results　There were five types of the atypical molybdenum X-ray manifestations of breast cancer: small lumps(diameter ≤10 mm), small calcification, non-symmetric restriction of dense shadow, structural distortion, and star sign.Conclusion　Molybdenum target X-ray has important diagnostic value for the atypical manifestation of breast cancer, and is a reliable imageological method to diagnose the breast cancer with the main manifestation of calcification. Combining other different technologies with molybdenum target examination can further improve the diagnostic rate.]]> 2018/3/2 17:10:11 XIAO Kuan-xiang, PENG Chang-li, YANG Yan-min 109true ［Abstract］　Objective　To study the effect of ultrasound guided microwave ablation on treatment of patients with benign thyroid nodules.Methods　100 patients with benign thyroid nodules were selected in our hospital from March 2015 to February 2017 and were divided into the observation group(n=50) and the control group(n=50) according to the different operation modes. The control group was given open surgery, while the observation group were given ultrasound guided microwave ablation. The levels of tumor necrosis factor-α(TNF-α), interleukin- 6(IL-6) and C-reaction protein(CRP), thyroid function and complications were compared between the two groups.Results　There were no significant differences in the preoperative levels of TNF-α, IL-6 and CRP between the two groups(P>0.05). The levels of TNF-α, IL-6 and CRP in the observation group were significantly lower than those in the control group 12 hours after the operation(P<0.01). There were no significant differences in the levels of free triiodothyronine(FT3), free thyroxine(FT4) and thyroid stimulating hormone(TSH) between the two groups before and after the operation(P>0.05). The incidence rates of wound pain, adhesion of incision and intraoperative bleeding in the observation group were significantly lower than those in the control group(P<0.05). The incidence of radioactive pain in the observation group was significantly higher than that of the control group(P<0.05).Conclusion　Ultrasound guided microwave ablation is safe and can reduce the surgical trauma effectively for the patients with benign thyroid nodules.]]> 2018/3/2 17:10:11 XIAO Lin-hai 108true ［Abstract］　Objective　To analyze the efficacy of erlotinib plus whole brain radiotherapy for non-small cell lung cancer with brain metastasis and its prognosis.Methods　90 patients with non-small cell lung cancer with brain metastases in our hospital were selected from May 2013 to July 2015 and were randomly divided into two groups, with 45 cases in each group. The control group was treated with whole brain radiotherapy for 3 weeks, with a total dose of 30 Gy/10 Fx. The observation group was treated with the same treatment as the control group plus erlotinib 150 mg/d for 3 weeks. The clinical efficacy, prognosis and the incidence of adverse reactions were compared between the two groups.Results　In the observation group, complete renission(CR) was in 3 cases, partial(PR) in 25 cases, stable disease(SD) in 13 cases and progressive disease(PD) in 4 cases. In the control group, CR was in 1 case, PR in 16 cases, SD in 11 cases and PD in 17 cases. The clinical efficacy of the observation group was higher than that of the control group(P<0.01). The average survival time and survival rate of the observation group were significantly higher than those of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion　Erlotinib combined with whole brain radiotherapy can effectively control the tumor growth, inhibit the tumor proliferation, and prolong the survival time for the patients with non-small cell lung cancer and brain metastases.]]> 2018/3/2 17:10:11 LU Ai-li 107true ［Abstract］　Objective　To investigate the clinical effect of ureteroscopic surgery on minimally invasive gallbladder-preserving cholecystolithotomy in primary hospital and to provide an alternative instrument for the primary hospitals without cholangioscopy.Methods　The clinical data of 50 patients who were performed minimally invasive gallbladder-preserving cholecystolithotomy from January 2013 to June 2016 were retrospectively analyzed.Results　All the operations were successful with average operation time of (62.3±15.5)min; and blood loss of (21.8±2.9)ml, and without postoperative biliary fistula complications. All the patients were rechecked by B ultrasound or CT and no residual stones were found 1 week after the operation. During the follow-up period of 24 months, 1 case relapsed in 36 cases.Conclusion　Ureteroscopy in proper use can take out all the gallstones in the patients in a primary hospital, with advantages of safety, minimal invasion and multi-purpose use of ureteroscopy.]]> 2018/3/2 17:10:11 XIE Zhi-hai, CHEN Han-bing, HE Hui-ke, et al. 106true ［Abstract］　Objective　To compare the differences of anxiety, depression status, social psychological factors and life quality between young and elderly patients with chronic renal failure and peritoneal dialysis.Methods　108 patients with chronic renal failure who received peritoneal dialysis were selected in our hospital during May 2011 and September 2016 and were divided into the young group(n=56) and the elderly group(n=52) according to the different ages. The scores of Self-rating Anxiety Scale(SAS) and Self-rating Depression Scale(SDS) were evaluated to assess the anxiety and depression. The assessments of Self-rating Social Support Scale(SS) and Quality of Life Questionnaire-74(GQOLI-74) were used to evaluate the social psychological factors and quality of life.Results　The SAS and SDS scores of the young group were significantly lower than those of the elderly group(P<0.01). The incidence rates of anxiety and depression in the young group were significantly lower than those in the elderly group(P<0.01). There were no significant differences in the objective and subjective supports, the utilization of support and the total scores of SS between the two groups after peritoneal dialysis(P>0.05). There were no significant differences in the psychological function and living status scores between the two groups after peritoneal dialysis(P>0.05), while the scores of physical function and social function and total scores in the young group were significantly higher than those in the elderly group(P<0.01).Conclusion　The incidence of anxiety and depression is lower while the quality of life is better in the young patients than in the elderly patients with chronic renal failure and peritoneal dialysis.]]> 2018/1/26 9:57:02 WANG Jin, XU Wen-jun, LI Ze-min, et al. 105true ［Abstract］　Objective　To investigate the correlation between the levels of plasma D-dimer, C-reactive protein(CRP) and calcitonin(PCT) and severity in elderly patients with community acquired pneumonia(CAP).Methods　126 elderly patients with CAP were collected in our hospital from January 2016 to February 2017 and their clinical data were retrospectively analyzed. The patients were divided into low-risk group(n=54), intermediate-risk group(n=45) and high risk group(n=27). Other 30 healthy people receiving physical examination were taken as the control group(n=30). The levels of pasmn D-dimer, CRP and PCT were detected and compared among the groups.Results　The levels of plasma D-dimer, CRP and PCT in the intermediate-risk group and the high-risk group were significantly higher than those in the low-risk group(P<0.05). The levels of plasina D-dimer, PCT and CRP in the high-risk group were significantly higher than those in the two other groups(P<0.05). The levels of plasma D-dimer, PCT and CRP in the patients with severe CAP were significantly higher than those in the patients without severe CAP（P<0.01）. The levels of D-dimer, PCT and CRP in the dead patients were significantly higher than those in the survival patients （P<0.01）. The severity of CAP was positively correlated with the levels of plasma D-dimer(r=0.539, P=0.005), CRP（r=0.329, P=0.008） and PCT（r=0.729, P=0.003）.Conclusion　The levels of plasma D-dimer, CRP and PCT are correlated with the severity of CAP in elderly patients-PCT and D-dimer which can be a predicting index for prognosis.]]> 2018/1/26 9:57:02 QIN Yong-min, WEI Qing, WEI Zhen, et al. 104true ［Abstract］　Objective　To analyse the anti-HIV antibody test results of inpatients, and to understand their epidemiological characteristics, and to provide evidence for the improvement of HIV test and counsel services.Methods　The data of inpatients receiving anti-HIV antibody test in our hospital from January 2013 to December 2015 were analyzed. All the specimens of the in patients were screened by our hospital and the positive and uncertain specimens were sent to Shangqiu City Center for Disease Control and Prevention for confirmation.Results　129 527 inpatients were included, among whom 31 cases were positive in 61 433 males, and 20 cases were positive in 68 094 females. The positive rates were 0.06%, 0.03% and 0.04% respectively in 2013, 2014 and 2015. There was no significant difference in male positive rate or female positive rate among the three years. The highest positive rate was found in the age group of 41～50 years old. The HIV positive inpatients distributed in 17 clinical departments. Most patients were found in the respiratory department. 17 cases had coinfection with HCV. 8 cases were coinfection with syphilis. 1 case had coinfection with HBV and syphilis. The coinfection rate of females was higher than that of males.Conclusion　The positive rate of HIV antibody is higher in the male inpatients than in female inpatients. The highest positive rate is in the age group of 41～50 years old. The awareness of protecting HIV inpatients should be strengthened in the medical staff to improve HIV screening work.]]> 2018/1/26 9:57:02 WANG Yong-fu, YAN Ming-guang, ZHANG Su-ying, et al. 103true ［Abstract］　Objective　To analyze the correlation between bilirubin and the severity of lesions and the clinical classification of coronary atheroscierofic heart disease(CHD).Methods　From January 2016 to December 2016, 183 patients with CHD were chosen as the CHD group and 90 other patients with non-CHD during the same period were chosen as the control group. The CHD group was divided into the single lesion subgroup(n=62), double branch lesion subgroup(n=77) and multiple vessel lesion subgroup(n=44) according to the results of coronary angiography. The CHD group was divided into the STEMI subgroup(n=41), NSTEMI subgroup(n=43), UAP subgroup(n=49) and SAP subgroup(n=50) according to the patients′ medical history and clinical features.Results　The levels of total bilirubin(TBIL), direct bilirubin(DBIL) and indirect bilirubin(IBIL) in the CHD group were significantly lower than those in the control group(P<0.05). The levels of TBIL, DBIL and IBIL decreased with the increasing numbers of vascular lesions(P<0.05), and the levels of TBIL, DBIL and IBIL were negative correlation with the numbers of vascular lesions(r=-0.433, P<0.05), (r=-0.392, P<0.05), (r=-0.415, P<0.05). The levels of TBIL, DBIL and IBIL in the STEMI and NSTEMI subgroups were lower than those in the UAP and SAP subgroups, and the level of TBIL in the UAP subgroup was lower than that in the SAP subgroup(P<0.05). The levels of TBIL, DBIL and IBIL were negative correlation with the numbers of vascular lesions(r=-0.388, P<0.05), (r=-0.314, P<0.05), (r=-0.353, P<0.05).Conclusion　The level of serum bilirubin is negatively correlated with the number of vascular lesions and the severity of CHD, which shows that the level of serum bilirubin may indicate the severity of coronary catery disease and the stability of plaques.]]> 2018/1/26 9:57:02 WU Shao-ping 102true ［Abstract］　Objective　To compare the clinical effect on adult inguinal hernia between laparoscopic totally extra-peritoneal and open tension free hernia repair.Methods　One hundred and eighty-two patients with inguinal hernia were divided into the laparoscopic group(n=96) and the open group(n=86). The laparoscopic group received inguinal hernia repair by laparoscopy and the open group was performed open tension-free hernia repair. The therapeutic effect was compared between the two groups.Results　The operative time was significantly longer, and the postoperative hospital stay, postoperative pain score(VAS), postoperative complications, and the levels of postoperative inflammatory factors(CRP, IL - 6 and TNF-α) were significantly less in the laparoscopic group than those in the open group(P<0.05).Conclusion　Compared with the open tension free hernia repair,the surgical treatment of inguinal hernia using the laparoscopic totally extra-peritoneal(TEP) has less surgery trauma, less inflammatory stress response and postoperative complications, and faster postoperative recovery.]]> 2018/1/26 9:57:02 ZHOU Zong-xi, LIAO Bo, LI Yong-zhou 101true ［Abstract］　Objective　To explore the clinical effect of Golden Bifidobacterium combined with mesalazine in treatment of children with active inflammatory bowel disease(IBD). Methods　Forty children with active IBD were divided into two groups, with 20 cases in each group. The control group was treated with mesalazine, and the observation group received Golden Bifidobacterium and mesalazine. The distribution of intestinal flora, the expressions of serum CRP, ESR and IL-23 and the levels of Th17 cells were compared between the two groups, and the clinical efficacy and adverse reactions were statistically analyzed in the two groups 2 months after the continuous treatment. Results　Compared with those after treatment, the numbers of intestinal escherichia coli, bifidobacteria, lactobacillus and enterococcus in the control group were not significantly changed, but the numbers of bifidobacteria and lactobacillus in the observation group were significantly increased and the number of enterococcus was significantly decreased(P<0.05). The levels of CRP, ESR, IL-23 and Th17 cells in the two groups were significantly decreased and those of the observation group were significantly lower than those of the control group(P<0.05). In the observation group, 10 cases were markedly effective, 9 cases effective, and 1 case ineffective. In the control group, 5 cases were markedly effective, 8 cases effective, and 7 cases ineffective. The clinical effect of the observation group was better than that of the control group(P<0.05). The incidence of adverse reactions in the observation group(5%) was significantly lower than that in the control group(35%)(P<0.05). Conclusion　The clinical effect of Golden Bifidobacterium combined with mesalazine is significantly effective in treatment of children with active inflammatory bowel disease. It can effectively inhibit the inflammatory reaction, restore the intestinal microecological balance, regulate the immune function, reduce the side effects of the gastrointestinal tract of mesalazine, and improve the clinical efficacy.]]> 2018/12/29 16:55:29 LIN Meng, CHEN Xian-e 100true ［Abstract］　Objective　To compare the sedative effect between intranasal dexmedetomidine and intravenous midazolam on child patients examined with computed tomography(CT). Methods　Sixty children with AsA physical status Ⅰ or Ⅱ scheduled for CT imaging were randomly divided into two groups: midazolam group(group M, n=30) and dexmedetomidine group(group D, n=30). Group M received intravenous midazolam 0.2 mg/kg, and groups D received intravenous intranasal dexmedetomidine 2 μg/kg. The onset time of sedation, the length of examination, the awakening time, the sedative effect and adverse reaction were compared between the two groups. Results　Compared with those in group M, the awakening time was significantly shorter(P<0.05) and the adverse reaction(including glossocoma, dysphoria and respiratory depression) rate was significantly lower in group D(P<0.05). There were no significant differences between the two groups in the onset time of sedation, the length of examination and the sedative effect(P>0.05). Conclusion　Both intranasal dexmedetomidine and intravenous midazolam can be used effectively and safely for pediatric CT sedation. The awakening time is shorter and the adverse reaction rate is lower in the child patients using intranasal dexmedetomidine than those in the child patients using intravenous midazolam for sedation when receiving CT examination.]]> 2018/12/29 16:55:29 MIN Yu-yi, LIN Jing, HE Qing-biao 99true ［Abstract］　Objective　To study the preventive effect of Mirena intrauterine device(IUD) on recurrent endometrial polyp after endometrial polyp electroresection. Methods　Ninety patients with endometrial polyps(single and multiple polyps) treated in our hospital from May 2013 to May 2015 were treated with electric resection of endometrial polyps. Of the 90 patients, 30 cases treated with postoperative Mirena IUD were taken as the Mirena group, 30 cases treated with postoperative oral drugs(megestrol acetate tablets) as the drug group, and 30 cases treated with simple endometrial polyp resection as the operation group. The three groups were followed up for 12 months, and the therapeutic effects were observed by color Doppler ultrasound to indicate the endometrial thickness. Results　The thickness(recurrence rate) in the Mirena group was significantly less than that in the drug group or in the operation group（P<0.05）. Conclusion　Mirena intrauterine device is effective in prevention of recurrent endometrial polyp after endometrial polyp electroresection.]]> 2018/12/29 16:55:29 LIU Kan-ping 98true ［Abstract］　Objective　To investigate the clinical effect of ambroxol hydrochloride combined with azithromycin on mycoplasma pneumonia in children and its influence on immune function. Methods　A total of 126 children with mycoplasma pneumonia who were treated in our hospital from February 2016 to September 2017 were divided into the research group and the control group by random number table method. The control group received the routine treatment plus injection of azithromycin. The research group received the same treatment as the control group plus ambroxol hydrochloride. The disappearance time of pulmonary rales and cough, the body temperature recovery, the improved situation of immune function and the clinical effect were compared between the two groups. Results　The disappearance time of pulmonary rales and cough, and the time of body temperature recovery in the research group was significantly shorter than that in the control group（P<0.05）. In the research group, 36 cases were markedly effective, 23 cases effective and 4 cases ineffective. In the control group, 24 cases were markedly effective, 27 cases effective and 12 cases ineffective. The clinical effect in the research group was significantly better than that in the control group（P<0.05）. There were no significant differences in the levels of CD3⁺, CD4⁺ and CD8⁺ between the two groups before treatment(P>0.05). The levels of CD3⁺, CD4⁺ and CD8⁺ were improved in both of the two groups after treatment, but the improvements in the research group were more obvious than those in the control group （P<0.05）. Conclusion　Ambroxol hydrochloride combined with azithromycin has a significant curative effect on treatment of mycoplasma pneumonia in children and it can improve the patients′ immune function.]]> 2018/12/29 16:55:29 LI Hai-ying 97true ［Abstract］　Objective　To investigate the effects of entecavir on hepatitis B virus DNA(HBV-DNA) and liver function in patients with decompensated hepatitis B liver cirrhosis. Methods　Sixty-two patients with decompensated hepatitis B liver cirrhosis from August 2014 to October 2016 were selected as the study subjects, and were divided into two groups according to the random number table method, with 31 cases in each group. The control group was treated with adefovir dipivoxil orally and the observation group was treated with entecavir for 6 months. HBV-DNA levels and liver function were compared between the two groups before and after treatment. Results　The level of HBV-DNA in the control group was significantly higher than that in the observation group(P<0.05). The decrease of HBV-DNA level in the observation group was significantly sharper than that in the control group(P<0.05). After treatment, the decreases of aspartate aminotransferase, glutamic-pyruvic transaminase and total bilirubin in the observation group were significantly sharper than those in the control group(P<0.05). Conclusion　　Entecavir can effectively reduce HBV-DNA levels in patients with decompensated hepatitis B liver cirrhosis, and improve their liver function and clinical effects.]]> 2018/11/22 14:41:33 YAO Xiang, JIANG Jing 96true ［Abstract］　Objective　To investigate the clinical effect of hysteroscopy combined with vaginal operation in treatment of uterine incision diverticulum after cesarean section. Methods　58 patients with uterine incision diverticulum after cesarean section in our hospital from July 2013 to May 2017 were selected as the research objects and were randomly divided into the control group(n=29) and the observation group(n=29). The control group was treated with vaginal surgery while the observation group was treated with hysteroscopy combined with vaginal surgery. The postoperative recovery, the treatment effect and the postoperative complications were compared between the two groups. Results　The curative effect of the observation group was better than that of the control group(P<0.05). Compared with those in the control group, the intraoperative blood loss was significantly less, and the postoperative hospital stay was significantly shorter, and the operation time was significantly loger in the observation group(P<0.05). The incidence of postoperative complications in the control group was significantly higher than that in the observation group(P<0.05). Conclusion　　Hysteroscopy combined with vaginal surgery is safe and effective in treatment of uterine incision diverticulum after cesarean section.]]> 2018/11/22 14:41:33 MA Zhi-fu, WANG Ying 95true ［Abstract］　Objective　To observe the curative effect and safety of self-made Chinese Medicine Lung Warming, Stasis Transforming and Panting Stabilizing Decoction on treatment of viral bronchitis in children. Methods　75 children with viral bronchitis belonging to cold and closed lung type of Chinese Medicine were collected from November 2016 to November 2017, and were divided into the treatment group(n=43) and the control group(n=32) according to different treatment methods. The treatment group received self-made Chinese Medicine Lung Warming, Stasis Transforming and Panting Stabilizing Decoction, and the control group was treated with ribavirin. The time of relieving the symptoms and signs, the time of hospitalization and the curative effect were compared between the two groups. Results　The recovery time of body temperature and shortness of breath, cough relief time, diarrhea improvement time in the treatment group were significantly shorter than those in the control group(P<0.05). The reduced time of moist rales, the rales disappearance time and wheezing rale disappearance time, and the wheezy phlegm and wheezy sound in the lungs were significantly shorter than those in the control group(P<0.05). The hospitalization time in the treatment group was significantly shorter than that in the control group(P<0.05). In the treatment group, 29 cases were cured, 12 effective and 2 ineffective. In the control group, 14 cases were cured, 11 effective and 7 ineffective. The effective rate in the treatment group was significantly higher than that in the control group(P<0.05), and the incidence of adverse reactions in the treatment group(11.63%) was significantly lower than that in the control group(31.25%)(P<0.05). Conclusion　　The self-made Chinese Medicine Lung Warming, Stasis Transforming and Panting Stabilizing Decoction is safe and effective in treatment of viral bronchitis in children.]]> 2018/11/22 14:41:33 HUANG Ling-ling, CHEN Zhuan-hong 94true ［Abstract］　Objective　To investigate the clinical effect of mifepristone combined with high intensity focused ultrasound(HIFU) on treatment of adenomyosis. Methods　92 patients with adenomyosis were selected in our hospital From May 2015 to May 2016 and were randomly divided into two groups, with 46 cases in each group. The control group was treated with HIFU only. The observation group received mifepristone plus HIFU treatment. The curative effect, degree of dysmenorrhea and the changes of menstruation were compared between the two groups. Results　The curative effect of the observation group was better than that of the control group(P<0.05). After treatment, the degree of pain, menstrual period, menstruation were improved in both of the two groups, and the improvements of the observation group were better than those of the control group(P<0.05). Conclusion　　Mifepristone combined with HIFU has a better clinical effect on the treatment of adenomyosis. It can effectively relieve dysmenorrhea, shorten the period of menstruation and reduce the amount of menstruation.]]> 2018/11/22 14:41:33 NIE Fang 93true ［Abstract］　Objective　To observe the clinical effect and safety of routine triple therapy combined with Danshen injection in treatment of gastric ulcer. Methods　140 patients with gastric ulcer were selected in our hospital. All of the patients were randomly divided into the observation group and the control group, with 70 cases in each group. The control group received the routine triple therapy, and the observation group was treated with Danshen injection plus the same treatment as the control group. All the patients were treated continuously for one month. The clinical symptoms, healing degree of ulcer, HP clearance and adverse reactions were compared between the two groups. Results　In the observation group, 44 cases were markedly effective, 22 cases effective, and 4 cases ineffective. In the control group, 33 cases were markedly effective, 20 cases effective, and 17 cases ineffective. The clinical effect of the observation group was better than that of the control gruop(P<0.05). The incidence of adverse reactions in the observation group(2.86%) was lower than that in the control group(11.43%)(P<0.05). Conclusion　　The routine triple therapy combined with Danshen injection is safe and effective in treatment of gastric ulcer.]]> 2018/11/22 14:41:33 JIA Yong-mei 92true ［Abstract］　Objective　To evaluate the diagnostic value of electromyography in entrapment of saphenous nerve. Methods　Neurological electromyography was performed on 57 patients with saphenous nerve entrapment syndrome and 20 healthy volunteers. The sensory conduction velocity, latency and amplitude of the knee and ankle segments were recorded respectively. The results were compared between two different groups of people. Results　The sensory conduction velocity of the recessed nerve was slower, the latent period was longer, the amplitude lower, and the segmental lesion of the nerve had more characteristics in the patients with saphenous nerve entrapment syndrome than those in the healthy volunteers. Conclusion　Electromyography examination can provide a diagnostic basis for saphenous nerve entrapment syndrome, and identify the extent of nerve damage and provide a basis for treatment.]]> 2018/10/26 9:09:11 ZOU You-quan, XU Wei 91true ［Abstract］　Objective　To study the choice of the modes of delivery for the parturients with scarred uterus and the outcome of vaginal delivery. Methods　422 cases with scarred uterus were collected in our hospital from March 2014 to March 2017, and were divided into the cesarean section group(n=210) and the vaginal delivery group(n=212) according to the modes of delivery. The rate of trial vaginal delivery, the amount of postpartum hemorrhage, the days of hospitalization, the Apgar scores of the newborns and the weight of the newborns were statistically analyzed and compared between the two groups. Results　The successful rate of trial production in vaginal delivery group was 80.77%. The amount of bleeding in the vaginal delivery group was significantly less than that in the cesarean section group(P<0.05), and the time of hospitalization in the vaginal delivery group was significantly shorter than that in the caesarean section group(P<0.05). There were no significant differences in the Apgar scores between the two groups(P>0.05). Conclusion　The successful rate of vaginal delivery is high. It is safe for the pregnant women with scarred uterus to deliver vaginally under the strict control of delivery indications.]]> 2018/10/26 9:09:11 CHEN Wei-ping, HUANG Yong-hua, ZHANG Qun 90true ［Abstract］　Objective　To explore the effect of nerve-sparing laparoscopic resection of colorectal cancer on male sexual and urinary function. Methods　A total of 40 cases of gastrointestinal surgery were selected in the Seventh People′s Hospital of Nanhai and the First People′s Hospital of foshan. The operations were conducted from January 2012 to October 2015, and all of the 40 patients received laparoscopic radical rectal cancer resection. The patients were divided into the control group(n=20, non-nerve-sparing) and the observation group(n=20, nerve-sparing). The patients were followed up for two years and the male sexual function and prostate symptom scores were compared between the two groups. Results　All the 40 patients were performed the operation successfully, non-shedding and exclusion cases. There were significant differences in the scores of erectile function and ejaculation function between the two groups(P<0.05). The improvements of urination and quality of life in the observation group were better than those in the control group(P<0.05). Conclusion　Nerve-sparing laparoscopic resection of colorectal cancer is the important way to greatly keep male sexual and urinary function and improves the patients′ quality of life.]]> 2018/10/26 9:09:11 HE Chao-xiong, WU Mu-bing, JI Yong 89true ［Abstract］　Objective　To explore the application effect of preventive ileostomy on anus-preserving operation for ultra-lower rectal cancer. Methods　72 patients with ultra-low rectal cancer who underwent anus-preserving operation were randomly divided into observation group and control group, with 36 cases in each group. The anus-preserving operation was performed for ultra-low rectal cancer in both of the two groups. The observation group received additional preventive ileostomy. The postoperative exhaust time, the extraction of drainage tube time, the postoperative hospital stay and the postoperative anastomotic leakage rate were compared between the two groups. Results　The postoperative exhaust time, the extraction of drainage tube time and the postoperative hospital stay in the observation group were significantly shorter than those in the control group(P<0.05). The postoperative anastomotic leakage rate in the observation group was lower than that in the control group, but without a significant difference between the two groups(P>0.05). Conclusion　Preventive ileostomy can promote the recovery of bowel function and shorten the postoperative hospital stay for the patients receiving anus-preserving operation for ultra-low rectal cancer.]]> 2018/10/26 9:09:11 BI Chao-kuan 88true ［Abstract］　Objective　To compare the clinical effects on gallbladder stones complicated with common bile duct stones between laparoscopic cholecystectomy+choledocholithotomy and open cholecystectomy+choledocholithotomy. Methods　Fifty-two patients with gallbladder stones complicated with common bile duct stones were divided into the laparoscopic group(n=26) and the open group(n=26). The laparoscopic group received cholecystectomy + choledocholithotomy+choledochoscope + T-tube drainage by laparoscopy and the open group was performed open cholecystectomy + choledocholithotomy + choledochoscope + T-tube drainage. The therapeutic effect was compared between the two groups. Results　The operative time was significantly longer, and the postoperative pain score(VAS), the rate of using postoperative painkillers, the levels of postoperative inflammatory factors(CRP, IL-6 and TNF-α), the postoperative gastrointestinal motility recovery and the postoperative hospital stay were significantly less in the laparoscopic group than those in the open group(P<0.05). Conclusion　Compared with open cholecystectomy+choledocholithotomy, laparoscopic cholecystectomy+choledocholithotomy has less surgery trauma, less inflammatory stress response and faster postoperative recovery in the treatment of gallbladder stones complicated with common bile duct stones.]]> 2018/10/26 0:00:00 ZHOU Zong-xi, LIAO Bo, LI Yong-Zhou 87true ［Abstract］　Objective　To observe the effects of hyperbaric oxygen therapy on post-operative cerebral vascular dynamics and brain edema in patients with hypertensive cerebral hemorrhage. Methods　Seventy-eight patients with hypertensive intracerebral hemorrhage treated in our hospital from April 2015 to March 2017 were selected as the research subjects and were divided into two groups by the random number table method. The control group(n=39) was given routine clinical treatment, and the observation group(n=39) was treated with hyperbaric oxygen therapy crmbined with routine clinical treatment. The post-operative cerebrovascular dynamics and brain edema volume were compared between the two groups. Results　There were no significant differences in the mean flow velocity(Vmean), mean flow rate(Qmean), peripheral resistance(PR) and dynamic resistance(DR) between the two groups before treatment(P>0.05). There was no significant difference in the volume of brain edema between the two groups 3 days after treatment(P>0.05). The Vmean and Qmean of the observation group was significantly higher than that of the control group, and the PR and DR of the observation group was significantly lower than that of the control group（P<0.05）. The brain edema volume of the observation group was significantly smaller than that of the control group 14 and 28 days after treatment(P<0.05). Conclusion　Hyperbaric oxygen therapy can promote the improvement of cerebral vascular hemodynamics, reduce the degree of cerebral edema and improve the prognosis in the patients with hypertensive intracerebral hemorrhage.]]> 2018/10/26 9:09:11 HE Yu-huai 86true ［Abstract］　Objective　To observe the clinical effects and safety of endometrial radiofrequency ablation by hysteroscopy in treatment of perimenopausal dysfunctional uterine bleeding. Methods　From July 2013 to June 2016, a total of 116 patients with perimenopausal dysfunctional uterine bleeding in our hospital were enrolled, and were randomly divided into the research group treated with hysteroscopic endometrial electroresection and the control group treated with hysteroscopic endometrial radiofrequency ablation, with 58 cases in each group. The operation time, intraoperative blood volume, hospital stay, clinical effects and incidence of postoperative complications were compared between the two groups. All the patients were followed-up for 6 months, and the changes of the levels of hemoglobin(Hb) were compared before and after treatment. Results　Compared with those in the control group, the operation time, intraoperative blood volume and hospital stay of the research group were significantly reduced(P<0.05). The total effective rate of the research group was slightly higher than that of the control group, without a significant difference between the two groups(P>0.05). The incidence of postoperative complications of the research group(3.45%) was significantly lower that that of the control group(17.24%)(P<0.05). The levels of Hb in the two groups after the treatment were significantly higher than those before the treatment(P<0.05). There were no significant differences in the levels of Hb between the two groups after treatment(P>0.05). Conclusion　Hysteroscopic endometrial radiofrequency ablation is effective in treatment of perimenopausal dysfunctional uterine bleeding,which causes less injury and less complications, and effectively alleviates anemia in the patients after the operation.]]> 2018/10/26 9:09:11 GUO Jie 85true ［Abstract］　Objective　To study the clinical efficacy of reduced glutathione combined with neurotrophic drugs in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods　110 neonates with hypoxic ischemic encephalopathy treated in our hospital from April 2014 to April 2016 were randomly divided into the observation group and the control group, with 55 cases in each group. The control group received ganglioside combined with citicoline treatment, and the observation group received the same treatment as the control group plus glutathione. The clinical efficacy, adverse reactions, neonatal behavioral neurological assessment(NBNA) scores, low density CT values of the white matter of brain lesions were compared between the two groups before and after treatment. Results　After treatment, NBNA scores and low density CT values of the white matter of brain lesions were higher than those before treatment in both of the two groups, with significantly higher NBNA scores and CT values in the observation group than those in the control group(P<0.05). The clinical curative effect of the observation group was better than that of the control group(P<0.05). There was no significantly different in adverse reation rate between the two groups. Conclusion　Reduced glutathione combined with neurotrophic drugs is effective in the treatment of neonatal hypoxic-ischemic encephalopathy. It can effectively improve the neonatal neurological behavior.]]> 2018/10/26 9:09:11 WANG Juan, LI Kai 84true ［Abstract］　Objective　To observe the effect of core stability training on rehabilitation of children with spastic hemiplegia. Methods　Eighty-eight children with spastic hemiplegia treated in our hospital from May 2014 to April 2017 were selected as the research subjects. They were divided into two groups by random number table method. The control group received routine training, while the observation group implemented the core stability training. The changes of overall stability index(SI) and coarse motor function were observed before and after treatment. Results　There were no significant differences in overall SI and scores of gross motor function measure(GMFM-66) between the two groups before treatment(P>0.05). After treatment, SI was smaller and GMFM-66 was higher in the observation group, with significant differences between the two groups(P<0.05). Conclusion　Core stability training is effective in the rehabilitation of children with spastic hemiplegia, which can significantly improve the overall balance of exercise, promote the recovery of limb function and improve the rehabilitation of the children.]]> 2018/10/26 9:09:11 JIANG Xi 83true ［Abstract］　Objective　To investigate the effects of dexmedetomidine on perioperative stress and recovery in patients undergoing laparoscopic totally extraperitoneal prosthesis. Methods　A total of 40 patients undergoing elective laparoscopic totally extraperitoneal inguinal prosthesis were randomly divided into dexmedetomidine group(group D) and saline group(group C), with 20 cases in each group. The patients in both groups were treated with tracheal intubation and intravenous anesthesia. In group D, a loading dose of dexmedetomidine hydrochloride(0.2 μg/kg) was administered 15 minutes before anesthesia induction, and intravenous pumping infusion of dexmedetomidine was maintained at 0.4 μg/(kg·h) intraoperatively untill 20 minutes before the end of the operation. The patients in group C were given the same amount of saline in the same way as those in group D. Intravenous pumping infusion of propofol and remifentanil was used for anesthesia maintenance, and the bispectral index(BIS) of EEG was maintained from 40 to 60. The mean artery pressure(MAP) and heart rate(HR) were recorded 15 minutes before anesthesia induction(T₀), 1 minute after tracheal intubation(T₁), at the beginning of surgery(T₂), at tracheal intubation(T₃), and at 30 minutes postoperatively(T₄). Peripheral venous blood was drawn to detect the levels of epinephrine(E), norepinephrine(NE) and blood glucose(Glu) at the time points of T₀, T₁, T₂, T₃ and T₄. The adverse events of bradycardia, tachycardia, hypertension, restlessness after extubation, nausea and vomiting were recorded. Results　In the patients of group D, the levels of E and Glu at T₁, T₂, T₃ and T₄ were significantly higher than those at T₀, and the levels of NE at T₁, T₂ and T₃ were significantly higher than those at T₀（P<0.05）. In the patients of group C, the levels of E, NE and Glu at T₁, T₂, T₃ and T₄ were significantly higher than those at T₀（P<0.05）. Compared with those in group C, the levels of E, NE and Glu at T₁, T₂, T₃ and T₄ in group D were significantly decreased（P<0.05）. In terms of adverse reactions, the number of cases of tachycardia, hypertension, restlessness after extubation, nausea and vomiting in group D was significantly lower than that in group C, but the number of cases of bradycardia was higher than that in group C. The total incidence of adverse reactions in group D（20.0%） was significantly lower than that in group C（65.0%）（P<0.05）. Conclusion　Dexmedetomidine is a highly selective α₂ adrenergic receptor agonist with central anti-sympathetic effects, definite sedative and analgesic effects, and can partially inhibit the stress response of the patients undergoing laparoscopic complete extraperitoneal herniorrhaphy and ensure the safety of the operation and improve the recovery quality.]]> 2019/9/30 8:42:00 SONG Xiao-qian, HAO Lei, CAI Jian 82true ［Abstract］　Objective　To evaluate the clinical effect of ozonated water irrigation combined with vacuum sealing drainage on necrotizing fasciitis. Methods　Thirty-two cases of necrotizing fasciitis were selected in our hospital from June 2102 to December 2017 and were randomly divided into the ozonated water group(treated with ozonated water irrigation combined with vacuum sealing drainage, n=16) and the control group(treated with normal saline combined with vacuum sealing drainage, n=16). The days of hospitalization, the hospitalization costs, the number of operation and the days of infection control were compared between the two groups. Results　The days of hospitalization in the ozonated water group (19.88±5.62)d were less than those in the control group［(28.13±9.61)d］(P<0.05). The hospitalization costs of the ozonated water group［(18263.31±6181.26)yuan］ were less than those of the control group［(29241.44±15189.48)yuan］(P<0.05). The operation times of the ozonated water group (2.94±0.77) were less than those of the control group (3.81±1.33)(P<0.05). The days of infection control in the ozonated water group［(10.31±4.27)d］ were less than those in the control group［(15.63±8.14)d］(P<0.05). Conclusion　Ozonated water irrigation combined with vacuum sealing drainage can shorten the hospitalization time, reduce the hospitalization costs and the times of operation, and effectively control the infection.]]> 2019/9/30 8:42:00 LI Yong-jun, CHEN Mian-zhi, ZHANG Zhi-hui, et al. 81true ［Abstract］　Objective　To investigate the expressions of microRNA-203(miR-203) and matrix metalloproteinase-3(MMP-3) in the peripheral blood of the patients with rheumatoid arthritis(RA) and their clinical significances. Methods　Sixty RA patients in our hospital were selected as the RA group, and 30 persons who took physical examination as the healthy control group. The expression of miR-203 was detected by quanticative real-time polyinerase chain reaction(QRT-PCR) and the expression of MMP-3 by enzyme-cinked immunosorbent assay(ELISA). ROC curve analysis was performed to evaluate the diagnostic sensitivity and specificity of RA. Results　The expressions of miR-203 and MMP-3 in the RA group were higher than those in the control group, and the expressions increased significantly in the active phase, and there was a significant positive correlation between them(r=0.700, P<0.01). Correlation analysis showed that there were positive correlations between miR-203, MMP-3 and RF, ACCP, ESR, CRP and DAS28(r=0.639, 0.474, 0.528, 0.518, 0.765, 0.816, 0.568, 0.520, 0.613, 0.594, P<0.01). ROC curve analysis showed that plasma miR-203 and MMP-3 had high diagnostic sensitivity and specificity for RA, and the combined detection improved the clinical diagnostic ability of the disease. Conclusion　The differential expressions of miR-203 and MMP-3 in the peripheral blood of the patients with RA have strong clinical diagnostic efficacy, and miR-203 and MMP-3 are expected to become a new clinical diagnostic indicators.]]> 2019/9/30 8:42:00 WU Chong-wen, YANG Xi-yong, ZHAO Xiao-yan, et al. 80true ［Abstract］　Objective　To investigate the clinical effects of different surgical positions of percutaneous nephrolithotripsy on treatment of complicated renal calculi. Methods　One hundred and fifty patients with complicated renal calculi were selected in our hospital from June 2016 to June 2018 and were divided into prone position group,oblique supine position group and rock-amputation oblique supine position group according to different surgical positions, with 50 cases in each group. The operation time, intraoperative blood loss, hospital stay, intraoperative postural comfort, stone clearance rate and complication rate were compared among the three groups. Results　The operation time of the rock-amputation oblique supine position group was significantly shorter than that of the oblique supine position group and the prone position group(P<0.01). The operation time of the oblique supine position group was significantly shorter than that of the prone position group(P<0.01). There were no significant differences in the intraoperative blood loss, hospital stay and stone clearance rate among the three groups(P>0.05). The intraoperative postural comfort scores of the patients in the rock-amputation oblique supine position group［(103.41±11.86)points］ were significantly higher than those in the oblique supine position group［(92.03±10.88)points］ and the prone position group［(91.76±10.83)points］(P<0.01). There were no significant differences in the intraoperative postural comfort scores between the oblique supine position group and the prone position group(P>0.05). The intraoperative postural comfort rate of the rock-amputation oblique supine position group was significantly higher than that of the prone position group and the oblique supine position group(P<0.05). There was no significant difference in the intraoperative postural comfort rate between the prone position group and the oblique supine position group(P>0.05). There was no significant difference in the rate of postoperative complications(infection, hemorrhage, renal injury, perirenal hematoma and intestinal damage) rate among the three groups(P>0.05). Conclusion　The clinical effects of percutaneous nephrolithotripsy on treating complicated renal calculi with prone position, oblique supine position and rock-amputation oblique supine position are equivalent, but the rock-amputation oblique supine position has shorter operation time and better comfortable position than the prone position group and the oblique supine position group.]]> 2019/9/30 8:42:00 WEI Gui-jian, HUANG Li-zhen 79true ［Abstract］　Objective　To explore the outcome and feasibility of vaginal delivery in the patients with secondary pregnancy and scarred uterus. Methods　Fifty-two patients with secondary pregnancy and scarred uterus who tried to deliver through the vagina in our hospital from January 2017 to December 2017 were selected as the study group and other 52 healthy pregnant women who had vaginal delivery in our hospital during the same period were selected as the control group. The delivery process of the patients with scarred uterus was observed, and the duration of labor, blood loss, hospitalization time and the incidence of postpartum infection and urinary retention were compared between the two groups, and the Apgar scores of the newborns were compared between the two groups. Results　There were no significant differences in the duration of labor, blood loss and length of hospital stay between the two groups(P>0.05). The success rate of vaginal delivery was 90.38% in the study group and 100.00% in the control group(P>0.05). There were no significant differences in the 1-minute Apgar scores, postpartum infection and urinary retention rates between the two groups(P>0.05). Conclusion　Scarred uterus is not the absolute indication of cesarean section. As long as the indications and contraindications of delivery are strictly controlled and the monitoring work is perfect, vaginal delivery is safe and feasible.]]> 2019/9/2 14:45:32 ZHU Qi, CAO Yong-li, LI Juan 78true ［Abstract］　Objective　To study the correlation between the level of serum potassium and creatine kinase-MB(CK-MB) in patients with acute myocardial infarction, and to investigate the effect of elevated serum potassium on the prognosis of acute myocardial infarction. Methods　The venous blood were collected and the blood potassium and CK-MB concentration were detected in 96 acute myocardial infarction patients at 16 hours of onset. The patients were divided into three groups according to different blood potassium levels: normal blood potassium group(n=36), slightly increased group(n=33), significantly increased group(n=27). The incidence rates of arrhythmia, shock, heart failure and death were compared among the three groups. Results　The blood potassium concentration was positively correlated with CK-MB, and the correlation coefficient was 0.920. The incidence rates of arrhythmia, heart failure, shock and death was 63.0%, 59.3%, 51.9% and 66.7% in the significantly increased group, and 27.8%, 8.3%, 2.8% and 2.8% in the normal blood potassium group, and 57.6%, 24.2%, 18.2% and 21.2% in the slightly increased group. The rates of the significantly increased group were significantly higher than those in the normal blood potassium group and the slightly increased group(P<0.01）. Conclusion　The increase of serum potassium concentration in patients with acute myocardial infarction is an important independent risk factor for serious complications and death and is an important indicator of poor prognosis in acute myocardial infarction.]]> 2019/9/2 14:45:32 GENG Li-qun, KOU Min-sheng, GENG Ai-qun 77true ［Abstract］　Objective　To observe the clinical effect of percutaneous nephrolithotomy(PCNL) on renal staghorn calculi. Methods　Fifty-eight patients with renal staghorn calculi treated with PCNL in our hospital from January 2014 to December 2017 were selected as the PCNL group. Other fifty-five patients with renal staghorn calculi treated with open surgery in the same period were selected as the open surgery group. The operation time, the intraoperative blood loss, the hospitalization time, the kidney fistula indwelling time, the phase Ⅰ calculi clearance rate, the costs of treatment and the postoperative complications were compared between the two groups. Results　The hospitalization time and the kidney fistula indwelling time in the PCNL group was significantly shorter than that in the open surgery group, but the operation time in the PCNL group was significantly longer than that in the open surgery group（P<0.05）. The intraoperative blood loss in the PCNL group was significantly less than that in the open surgery group, but the treatment costs in the PCNL were significantly higher than those in the open surgery group（P<0.05）. The phase Ⅰ calculi clearance rate in the PCNL group was lower than that in the open surgery group, but there was no significant difference between the two groups（P>0.05）. The incidence of postoperative complications in the PCNL group was significantly lower than that in the open surgery group（P<0.05）. Conclusion　PCNL has the advantages of less intraoperative blood loss, shorter hospital stay and lower incidence of complications for the treatment of renal staghorn calculi, and its phase Ⅰ calculi clearance rate is equivalent to that of open surgery.]]> 2019/9/2 14:45:32 CHEN Ning 76true ［Abstract］　Objective　To establish a method for the determination of cadmium in metronidazole raw materials. Methods　Graphite furnace atomic absorption spectrometry(GFASS) was used to determine the metronidazole samples after microwave digestion. The cadmium determination wavelength was 228.8 nm, the slit was 0.7 nm, and the light source current was 8 mA. Results　There was a good linear relationship between cadmium concentrations and absorbances in the linear range of 0～2 ng/ml, and the average recovery was 98.4%(RSD=1.2%, n=9). Conclusion　The method has the advantages of accuracy, quickness,specificity, low detection limit, high precision, good recovery, wide linear range and good stability.]]> 2019/9/2 14:45:32 ZHENG Li-wei 75true ［Abstract］　Objective　To investigate the frequency of the occurrence of elementary school students′ self-reported and their parents′ proxy-reported dental anxieties, and to study the differences between them. Methods　Sixty elementary school students and their fathers or mothers were enrolled for the separate investigation by the Modified Dental Anxiety Scale(MDAS). The interrater agreement on individual question scores was analyzed using percentage agreement and linear weighted Kappa coefficient. Results　Self-reported and proxy-reported dental anxieties were common in the elementary school students and their parents. However, the scores of the students′ self-reported dental anxieties were higher than those of their parents′ proxy-reported dental anxieties(MDAS-Q 1-5, P<0.05). MDAS-Q5 was the most agreed question with Kappa coefficient of 0.551 and P value of less than 0.001. However, 33.3% of the students′ self-reported dental anxieties were underestimated for MDAS-Q5. Conclusion　Elementary school students′ self-reported dental anxieties differs from their parents′ proxy-reported dental anxieties, which suggests that self-reported dental anxieties by children should be encouraged and adopted.]]> 2019/8/5 16:14:38 FU Su-wei, ZHANG Yan, LI Shen, et al. 74true ［Abstract］　Objective　To analyze the effects of simple lithotripsy combined with tamsulosin hydrochloride sustained-release tablets in treatment of benign prostatic hyperplasia complicated with bladder stones. Methods　Ninety-six patients with benign prostatic hyperplasia complicated with bladder stones were selected in our hospital from April 2015 to April 2018 and were randomly divided into control group and observation group, with 48 cases in each group. The control group was treated with pneumatic ballistic lithotripsy for bladder stones, and was treated with tamsulosin hydrochloride sustained-release tablets after operation for lower urinary tract obstruction due to benign prostatic hyperplasia. The observation group was treated with prostate electrotomy and pneumatic lithotripsy for bladder stones, and was treated with tamsulosin hydrochloride sustained-release tablets after operation for lower urinary tract obstruction due to benign prostatic hyperplasia. Preoperative and postoperative prostate symptoms, the rate of removed urinary calculi and incidene of complications were compared between the two groups. Results　There were no significant differences in preoperative prostate symptoms between the two groups(P>0.05). The prostate symptoms were improved after operation in both of the two groups(P<0.05), but the indexes in the observation group were better than those in the control group(P<0.05). Conclusion　Tamsulosin hydrochloride sustained-release tablets can consolidate the therapeutic effect of prostate electrotomy and pneumatic lithotripsy on benign prostatic hyperplasia complicated with bladder stones. The combined treatment has a good effect on prostatic hyperplasia.]]> 2019/8/5 16:14:38 LIU Zhuo-wei 73true ［Abstract］　Objective　To study the effect of integrated comprehensive interventions on type 2 diabetes mellitus（T2DM） in community residents. Methods　Seven hundred and ninety-eight residents in the community of South China Agricultural University were randomly recruited for the study by the multi-phase- stratified -cluster sampling method. All the patients were diagnosed with T2DM and received routine treatment for T2DM. The changes of related metabolic indexes, medication compliant behaviors and behavior patterns of living were compared before and after interventions. Results　After interventions, the levels of glycosylated hemoglobin(HbA1c), total cholesterol(TC) and triglyceride(TG) were significantly lower than those before interventions（P<0.05）. After interventions, the treatment rate（99.00% vs 77.82%, χ²=174.625, P=0.001）, the clinical compliance rate（91.60% vs 60.90%, χ²=207.699, P=0.001）, the rate of blood glucose test rises from 47.12% to 87.59%(χ²=297.298,P=0.001), the rate of diabetes recognition （87.97% vs 19.55%, χ²=751.406, P=0.001）, the salt limited intake rate（90.47% vs 48.75%, χ²=328.447, P=0.000） and the oil limited intake rate（96.12% vs 48.25%, χ²=455.328, P=0.001） were significantly higher than those before interventions. Conclusion　The intervention measures given by the community hospital are significantly effective for type 2 diabetes mellitus in the community residents.]]> 2019/8/5 16:14:39 ZHOU Ying, FAN Sui-guang, CHEN Xiao-cong 72true ［Abstract］　Objective　To detect the levels of serum carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA199) and carbohydrate antigen 125(CA125) in the patients with advanced lung adenocarcinoma before and after chemotherapy, and to explore the correlation between the tumor markers and short-term curative effects. Methods　Sixty-four patients with advanced lung adenocarcinoma who were admitted to Henan Hongli Hospital from January 2012 to January 2017 were treated with the chemotherapy of pemetrexed in combination with cisplatin(AP regimen). The levels of serum CEA, CA199 and CA125 were detected before and two weeks after chemotherapy. The evaluation on imaging efficacy was conducted. Results　Of the 64 patients receiving AP regimen, 1 case got complete remission, 22 partial remission, 22 stable disease and 19 disease progression. The levels of CEA, CA199 and CA125 in the patients with complete remission or partial remission were significantly decreased(P<0.05), while the levels of CEA, CA199 and CA125 in the patients with stable disease had no significant differences before and after treatment(P>0.05). The levels of CEA, CA199 and CA125 in the patients with disease progression were significantly increased after treatment(P<0.05). Before treatment, the levels of CEA, CA199 and CA125 in the patients with complete remission or partial remission were significantly higher than those in the patients with stable disease or disease progression(P<0.05). Before treatment, there were no significant differences in the levels of CEA, CA199 and CA125 between the patients with stable disease and those with disease progression(P>0.05). Conclusion　The changes of serum CEA, CA199 and CA125 levels have certain value in predicting the short-term curative effect for the patients with lung adenocarcinoma after chemotherapy. The patients with high serum levels of CEA, CA199 and CA125 may have better chemotherapeutic effect.]]> 2019/8/5 16:14:39 CHEN Wan-zhen, YIN Hai-qing 71true ［Abstract］　Objective　To summarize the treatment experience of opposite NUSS operation on the children with pectus carinatum in Kunming Children′s Hospital. Methods　Fifteen cases of pectus carinatum were performed opposite NUSS operation, including 12 cases of male children and 3 cases of female children with an age range of 8.5～14.0 years［average (10.17±2.70) years］. Opposite NUSS operation was performed to put an orthopedic steel plate on the sternum surface, and the curved steel plate was pressed downward, and then the sternum was raised and flattened. Results　All the 15 cases were operated successfully, and the average operation time was 105 minutes and a little bleeding occurred. No serious complications were observed. The 15 patients had a good postoperative effect. After a follow up of 4～24 months, the effect was stable and satisfactory. No steel plate displacement occurred. Conclusion　Opposite NUSS operation is safe and feasible for pectus carinatum in children, and the surgical effect is statisfactory. The optimal age for the surgery is 6～16 years. However, the long-term results of the surgery and whether the deformed sternums continue to develop still need to observe.]]> 2019/7/1 16:32:50 ZHANG Hong 70true ［Abstract］　Objective　To observe the treatment of Kangfuxin combined with iodine glycerol in children with acute suppurative tonsillitis and its effects on inflammatory mediators including inflammatory medium serum procalcitonin(PCT), C- reactive protein(CRP) and interleukin-6(IL-6). Methods　Two hundred and fifty hospitalized children with acute suppurative tonsillitis were divided into observation group and control group according to the principle of random allocation, with 125 cases in each group. All the children were treated with anti infection, abatement of fever and nutritional support and other conventional treatments. The observation group was treated with Kangfuxin combined with iodine glycerol. The levels of serum PCT, CRP and IL-6 were observed before and 3 days after treatment in the two groups. The clinical efficacy was compared between the two groups. Results　The levels of serum PCT, CRP and IL-6 were decreased in the two groups after treatment. The decreases of the observation group were more obvious than those of the control group(P<0.05). In the observation group, 75 cases were cured, 40 cases markedly effective and 10 cases ineffective. In the control group, 40 cases were cured, 35 cases markedly effective and 50 cases ineffective. The curative effect of the observation group was better than that of the control group（P<0.01）. Conclusion　Kangfuxin combined with iodine glycerol has good curative effect in treatment of children′s acute suppurative tonsillitis. It can reduce the serum levels of PCT, CRP and IL-6.]]> 2019/7/1 16:32:50 YU Yan-mei, ZHOU Feng-qia, YU Qia-chao, et al. 69true ［Abstract］　Objective　To observe the clinical effect of glucocorticoids on eosinophilic positive patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods　Sixty AECOPD patients were divided into eosinophilic positive group(n=33) and eosinophilic negative group(n=27) according to the percentage of eosinophils in peripheral blood, and the two groups were given methylprednisolone 40 mg daily for 5 days. The levels of C-reactive protein(CRP) and interleukin-8(IL-8) were detected on the first day and the seventh day of admission. The clinical efficacy was evaluated on the seventh day of admission. Results　The levels of CRP and IL-8 in the eosinophilic positive group were decreased significantly compared with those in the eosinophilic negative group. In the eosinophilic positive group, 21 cases were cured, 10 cases improved, and 2 cases ineffective. In the eosinophilic negative group, 12 cases were cured, 6 cases improved, and 9 cases ineffective. The eosinophilic positive group had better clinical efficacy than the eosinophilic negative group（P<0.05）. Conclusion　Glucocorticoids have a better clinical effect on the eosinophilic positive patients with AECOPD than the with eosinophilic negative patients with AECOPD.]]> 2019/7/1 16:32:50 LIN Yun-tuan, ZENG Hai-li, JIANG Rong-fei, et al. 68true ［Abstract］　Objective　To investigate the efficacy and safety of minimally invasive percutaneous nephrolithotomy(mPCNL) and flexible ureteroscopy lithotripsy(FURL) in treating kidney stones of 2～3 cm in diameter. Methods　A retrospective analysis was performed on 67 patients with kidney stones of 2～3 cm in diameter treated in our hospital from May 2015 to February 2018, including 44 cases in the mPCNL group, and 23 cases in the FURL group. The operation time, amount of intraoperative bleeding, length of postoperative stay in hospital, scavenging rate of stones, total hospitalization expense, occurrence of secondary operation and postoperative complications were compared between the two groups. Results　Compared with the FURL group, the mPCNL group had less operation time and total hospitalization cost, the differences were statistically significant（P<0.05）. However, the intraoperative blood loss and postoperative hospital stay in the mPCNL group were more than those in the FURL group, the differences were statistically significant（P<0.05）. In the mPCNL group, the total scavenging rate of stones was 95.45%; 41 patients had gross hematuria; 1 patient had severe gross hematuria on day 3 after surgery, with sustained reduction of hemoglobin, selective renal arteriography indicated that this patient had pseudoaneurysm and embolization was performed. 5 patients had fever without systemic inflammatory response syndrome（SIRS） complications; renal subscapular hematomas were found in 6 patients by CT re-examination, in whom the hematomas were absorbed in the re-examination 3 months later; 2 patients had retained stones locating at the lower calyx which were not treated due to other causes. In the FURL group, the total scavenging rate of stones was 91.30%; 15 patients had gross hematuria to varying degrees, which disappeared without treatment 1 to 3 days after occurrence; postoperative SIRS occurred in 8 patients who were treatment with TIENAM(imipenem) for anti-infection; ureteral injury occurred in 5 patients, which was caused by sheath withdrawal during the operation and repeated inserting of the sheath; the formation of “stone street” was found in 3 patients who were given extracorporeal shock wave lithotripsy（ESWL） treatment; 1 patient with preoperative infection accompanied by diabetes had renal subscapular hematoma and was provided with conservative treatment, and the hematoma was found to absorb by CT re-examination 12 weeks later. Conclusion　Both mPCNL and FURL are safe and effective in treating single kidney stone of 2～3 cm in diameter, which are suitable for clinical application.]]> 2019/5/31 17:17:33 LI Gan-hong, LI Qian-wei, YANG Jun, et al. 67true ［Abstract］　Objective　To analyze the pregnancy outcome and the influencing factors of vaginal delivery of scar uterus. Methods　The clinical data of the pregnant women with scar uterus treated in our hospital from March 2014 to August 2016 were retrospectively analyzed. According to the modes of delivery, the patients were divided into the vaginal delivery group and the cesarean section group. The changes of hemodynamics and neonatal Apgar score were observed in the two groups before and after delivery, and the influencing factors affecting the vaginal delivery of scar uterus were analyzed. Results　There were no significant differences in hemodynamic parameters before delivery. After delivery, the levels of hemoglobin(Hb) and platelet(PLT) in the vaginal delivery group were higher than those in the cesarean section group(P<0.05), while there were no differences in the levels of SpO₂, P_ETCO₂ and CVP between the two groups（P>0.05）. The incidence rates of aspiration pneumonia, intracranial hemorrhage and Apgar scores after birth showed no significant differences between the two groups(P>0.05). The 24- hour bleeding volume of the vaginal delivery group［（234.45±15.42）ml］ after delivery was significantly less than that of the cesarean section group［(385.62±14.56)ml］(P<0.05). Logistic regression analysis showed that the last cesarean section time, fetal weight, prepregnance BMI and vaginal birth history were associated with vaginal delivery（P<0.05）. Conclusion　Vaginal delivery is feasible for the repregnant women with scar uterus and the multiparas usually have a better prognosis of vaginal delivery. The last cesarean section time, fetal weight, prepregnance BMI and vaginal birth history are the influencing factors of vaginal delivery of scar uterus.]]> 2019/5/31 17:17:33 ZHANG Shu-jing 66true ［Abstract］　Objective　To investigate the efficacy of hysteroscopic surgery for the treatment of type Ⅱ cesarean scar pregnancy(CSP) in the first trimester. Methods　One hundred and ten patients with type Ⅱ CSP in the first trimester were selected in the Department of Obstetric and Gynecology in our hospital from August 2015 to August 2017, and were randomly divided into the control group and observation group, with 55 cases in each group. The control group received uterine scar pregnancy debridement surgery, and the observation group was treated with hysteroscopic surgery.The surgical efficacy was compared between the two groups. Results　The surgical time, the amount of bleeding during surgery, the time for postoperative serum human chorionic gonadotropin(HCG) returning to the normal level, the postoperative hospitalization time, the menstrual recovery time and the rate of adverse reactions in the observation group were significantly shorter or lower than those in the control group（P<0.05）. Conclusion　Hysteroscopic surgery is safe and effective in the treatment of type Ⅱ cesarean scar pregnancy in the first trimester.]]> 2019/5/31 17:17:33 DANG Shui-ying 65true ［Abstract］　Objective　To investigate the effect of ureteroscopic holmium laser lithotripsy on ureteral calculi. Methods　The data of 60 patients with ureteral calculi from February 2016 to December 2017 were respectively analyzed. The patients were divided into observation group and control group according to different operation methods. The control group(n=30) underwent ureteroscopic pneumatic lithotripsy, and the observation group(n=30) underwent ureteroscopic holmium laser lithotripsy. The urinary calculi removal rate, postoperative ambulation time, postoperative intestinal exhaust time, duration of use of analgesics, length of hospitalization, Visual Analogue Scale(VAS) scores before and after surgery, WHOQOL-100 Quality of Life scores and ureteral injury were compared between the two groups. Results　The total effective rate of the observation group was significantly higher than that of the control group(P<0.05). The postoperative ambulation time, postoperative intestinal exhaust time, duration of use of analgesics and length of hospitalization in the observation group were significantly shorter than those in the control group(P<0.05). There were no significant differences in VAS scores and WHOQOL-100 Quality of Life scores between the two groups before surgery(P>0.05). After surgery, the VAS scores and WHOQOL-100 Quality of Life scores in the observation group were better than those in the control group(P<0.05). The ureteral injury in the control group was significantly worse than that in the control group, but there was no significant difference(P>0.05). Conclusion　Ureteroscopic holmium laser lithotripsy is effective for the patients with ureteral calculi. It can significantly reduce the ureteral injury, accelerate the postoperative recovery, reduce the patients′ suffering and improve their quality of life.]]> 2019/5/31 17:17:33 LIU Xiong-zhao 64true ［Abstract］　Objective　To summarize the clinical features, diagnosis and treatment of intraorbital vegetative foreign bodies. Methods　The data of 19 patients with intraorbital vegetative forein bodies confirmed by surgery from January 2001 to December 2018 were retrospectively analyzed. The clinical manifestations, imaging signs, treatment and follow-up results were summarized. Results　All the 19 patients had eyelid swelling, conjunctival congestion, repeated purulence and wound nonunion. CT examination was performed on all the 19 cases, and 11 cases showed low density foreign bodies with peripheral soft tissue hyperplasia. CT signs vary with the nature of foreign bodies. All the 19 patients were cured by surgical removal of the foreign bodies, removal of residual debris and fistula resection. Conclusion　Orbital vegetative foreign bodies have different characteristics from metallic foreign bodies, and the imaging display rate is low. For the patients with intraorbital vegetative foreign bodies, careful examination should be carried out to remove the foreign bodies thoroughly, so as to avoid the wound delayed and healing, and obtain a good prognosis.]]> 2019/4/30 17:22:17 ZHANG Jiu-ming, TENG Cui-chan, HUANG Hui, et al. 63true ［Abstract］　Objective　To compare the clinical features of gastroesophageal reflux disease between young middle-aged and elderly patients. Methods　The clinical data of 80 case of gastroesophageal reflux disease selected in our hospital during March 2014 and February 2017 were retrospectively analyzed. The patients were divided into the young middle-aged group(n=47, <60 years) and the elderly group(n=33, ≥ 60 years). The severity of the symptoms and the quality of life were compared between the two groups. Results　The scores of heartburn symptoms in the young middle-aged group were significantly higher than those in the elderly group(P<0.05). The scores of reflux and chest pain symptoms in the young middle-aged group were significantly lower than those in the elderly patients(P<0.05). There were no significant differences in emotional function, health status, physiological function, and social function scores between the two groups(P>0.05). Conclusion　The elderly patients have more severe gastroesophageal reflux disease and their clinical features mainly are the symptoms of reflux and chest pain, but their quality of life is not affected.]]> 2019/4/30 17:22:17 HUANG Huan-shen, LIN Huan-xiong 62true ［Abstract］　Objective　To study the clinical effect and application value of cervical balloon dilator in the induction of labor in women with full-term pregnancy. Methods　A total of 130 women with full-term pregnancy who required induced labor in our hospital from January 2017 to December 2017 were selected as the study subjects. They were divided into observation group and control group according to the different methods of maternal labor induction, with 65 cases in each group. The control group received oxytocin induction and the observation group received cervical balloon dilator. The induction effect was compared between the two groups. Results　The vaginal delivery rate of the observation group(92.31%) was higher than that of the control group(73.85%)(P<0.05). The start-up time, total labor time, and length of stay in the observation group were shorter than those in the control group（P<0.05）. The blood loss in the observation group was less than that in the control group(P<0.05). The incidence rates of post-induction labor infection and placental abruption in the observation group were lower than those in the control group（P<0.05）. The satisfaction degree of the pregnant women in the observation group(95.38%) was higher than that in the control group(81.54%). Conclusion　Cervical balloon dilator can improve the vaginal delivery rate during the induction of labor in the pregnant women with full-term pregnancy. It can elevate the success rate of induced labor and the satisfaction degree of the pregnant women.]]> 2019/4/30 17:22:17 HU Jin, YANG Lin 61true ［Abstract］　Objective　To observe the effect of compound phellodendron gargle on radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients. Methods　A total of 83 nasopharyngeal carcinoma patients were randomly divided into observation group and control group. The observation group(n=42) was treated with radiotherapy plus compound phellodendron oral gargle, while the control group(n=41) was treated with radiotherapy plus compound chlorhexidine gargle. The incidence of oral mucositis was evaluated by Common Terminology Criteria for Adverse Events(CTCAE) v3.0 and the incidence of oral pain was evaluated by Verbal Rating Scale(VRS) in the two groups at the end of the clinical trial. Results　Compared with that in the control group, the incidence of oral mucositis in the observation group was significantly decreased(P<0.05). The degree of oral pain in the observation group was lower than that in the control group(P<0.05). Conclusion　Compound phellodendron gargle can attenuate the radiotherapy-induced oral mucositis and oral pain in nasopharyngeal carcinoma patients.]]> 2019/4/30 17:22:17 SONG Zhi-qiang, ZHENG Yan, LUO Rui 60true ［Abstract］　Objective　To evaluate the clinical efficacy of 25G pars plana vitrectomy combined with intravitreal Conbercept pretreatment for proliferative diabetic retinopathy(PDR). Methods　The clinical data of 52 patients(52 eyes) with PDR treated with pars plana vitrectomy were retrospectively analyzed. All the patients were divided into experimental group(n=25, 25 eyes) and control group(n=27, 27 eyes) according to whether or not they received intravitreal Conbercept on day 7 before pars plana vitrectomy. The overall surgical time, intraoperative complications and the best corrected visual acuity(BCVA) for three months postoperatively were compared between the two groups. Results　The average surgical time and the number of intraoperative bleeding, intraoperative coagulation, iatrogenic retinal injury, and silicone oil filling in the experimental group were significantly less than those in the control group(P<0.05). The BCVA of the experimental group was significantly better than that of the control group 3 months after operation(P<0.05). No other systemic adverse reactions were observed in the two groups. Conclusion　Intravitreal Conbercept can significantly reduce the operative time and the intraoperative complications and improve the postoperative vision for the patients with PDR 7 days before 25G pars plana vitrectomy.]]> 2019/4/30 17:22:17 MO Xiong-jun, XU Fan, HAN Guang-jie 59true ［Abstract］　Objective　To observe the clinical effect of B-Lynch suture on postpartum hemorrhage in maternity patients with uterine inertia. Methods　Ninety maternity patients with postpartum hemorrhage caused by uterine inertia were selected as the study subjects in the Department of Gynecology and Obstetrics of our hospital from September 2014 to September 2017. The patients were divided into study group(n=45) and control group(n=45) according to different treatment methods. The study group was treated with B-Lynch suture, and the control group was treated with traditional methods. The clinical effect was compared between the two groups. Results　The blood transfusion volume and the 24-hour blood bleeding volume in the study group were less than those in the control group［(635.27±290.65)ml vs (1260.35±366.54)ml, (540.35±220.65)ml vs (1190.70±420.90)ml (P<0.05)］. The total rate of complications in the study group was significantly lower than that in the control group(11.11% vs 35.56%)(P<0.05). Conclusion　B-Lynch suture improves the clinical effect on postpartum hemorrhage in maternity patients with uterine inertia.]]> 2019/4/30 17:22:17 MENG Jia-jia 58true ［Abstract］　Objective　To observe the content changes of procalcitonin(PCT) and neuron specific enolase(NSE) in serum and cerebrospinal fluid(CSF) in children with intracranial infections caused by different pathogens. Methods　Sixty-two cases of intracranial infections were selected, including 30 cases of purulent meningitis(PM group) and 32 cases of viral encephalitis(VE group). Thirty-three cases of suspected central nervous system infection were set as control group. The levels of PCT and NSE in the patients′ serum and CSF were detected. The correlations between PCT, NSE and sugar and protein indexes in the CSF were analyzed. Results　The levels of serum and CSF PCT in the PM group were significantly higher than those in the VE group and the control group(P<0.05). The levels of serum and CSF NSE in the VM group were significantly higher than those in the PM group and the control group(P<0.05). Compared with those in the VM group and the control group, the sugar level decreased and the protein level increased significantly in CSF in the PM group(P<0.05). There was a strong positive correlation between serum PCT, NSE and CSF PCT and NSE levels(P<0.001). The levels of PCT in serum and CSF were positively correlated with the elevated CSF protein(P<0.001), and the levels of PCT in serum and CSF were negatively correlated with the decreased CSF glucose(P<0.001). Conclusion　The changes of PCT and NSE levels in both serum and CSF can help to determine the type of intracranial infections and the degree of brain injury. The detection of PCT and NSE in serum is simpler, easier and faster than that in cerebrospinal fluid, and is worthy of clinical application.]]> 2019/4/1 16:03:54 LIN Meng, FANG Qiong 57true ［Abstract］　Objective　To observe the clinical effect of Bailing capsules on early diabetic nephropathy. Methods　Forty patients with early diabetic nephropathy were randomly divided into observation group and control group, with 20 cases in each group. Both the observation group and the control group were treated with conventional drug irbesartan, and the observation group was treated with Bailing capsules. The clinical effects of the two groups were evaluated 8 weeks after treatment. Results　Compared with that in the control group, the 24-hour urinary albumin quantification was significantly decreased in the observation group 8 weeks after treatment（P<0.05）. Conclusion　Bailing capsules can reduce urinary albumin and have a good clinical effect on early diabetic nephropathy.]]> 2019/4/1 16:03:54 LI Na 56true ［Abstract］　Objective　To explore the relationship between maternal prenatal education and behavior problems in preschool children and to provide the evidence for behavior intervention in the local district. Methods　Nine thousand two hundred and eighty-nine preschool children, aged 3 to 4 years old, with behavior problems were investigated by Conners parents questionnaire in Longhua new district of Shenzhen city. The maternal prenatal educations were investigated by self-designed questionnaire and were divided into three groups according to the fetal education frequency: group A(occasional prenatal education, ≤3 times monthly), group B(frequent prenatal education, 1 to 4 times weekly), and group C(prenatal education almost every day, 5 to 7 times weekly). Results　The more times of music and language prenatal education the mothers gave, the lower scores of six factors of behavior problems(learning, psychosomatic, hyperactivity impulses, anxiety and hyperactivity problems) the preschool children got （P<0.05）. The more times of prenatal caress education, the lower scores of two factors of behavior problems and learning problems in children′s psychology and behavior （P<0.05）. Conclusion　Maternal prenatal education especially music and language teaching can beneficially reduce the behavior problems of preschool children.]]> 2019/4/1 16:03:54 LUO Bi-yun, XIAN Dan-xia 55true ［Abstract］　Objective　To observe the clinical effect of peroneal neurolysis combined with straightening priority on severe valgus knee arthroplasty. Methods　Thirty-four patients receiving severe valgus knee arthroplasty were collected in our hospital. The patients were treated with peroneal nerve neurolysis plus extension osteotomy and straightening priority treatment. The changes of joint activity were compared before and 2 weeks, 6 weeks after operation. The changes of knee joint function were compared before and 6 months and 12 months after operation. Results　No serious complications such as nerve injury, infection and pulmonary embolism were found after operation. The activity of joints improved significantly 2 weeks and 6 weeks after operation(P<0.05), and the activity of joints 6 weeks after operation was significantly higher than that 2 weeks after operation(P<0.05). 6 months and 12 months after operation, the Knee Society Score(KSS) clinical scores, KSS function scores and Visual Analogue Scale(VAS) scores were significantly higher than those before operation(P<0.05). There were no significant differences in the above scores between 6 and 12 months after operation(P>0.05). Two cases occurred lower extremity intermuscular vein and deep vein thrombosis. Conclusion　Peroneal nerve neurolysis plus straightening priority treatment has good clinical application value for severe valgus knee arthroplasty. It is safe can effectively improve the postoperative joint mobility and the knee joint function, and relieve the patients′ knee joint pain.]]> 2019/4/1 16:03:54 ZHAO Wei, MA Jun, TAN Ying-dong, et al. 54true ［Abstract］　Objective　To observe the clinical effect of arthroscopy in treatment of traumatic arthritis after the ankle fracture. Methods　From February 2014 to September 2016, 44 patients with traumatic arthritis after ankle fracture treated in our department were selected as the observation group. 44 cases receiveing traditional open surgery were taken as the control group. The curative effect, operation time, intraoperative blood loss, recovery time and complicutions were compared between the two groups. Results　The curative effect of the observation group was better than that of the control group（P<0.05）. The improvements of the operation time, the amount of intraoperative bleeding, recovery time in the observation group were better than those in the control group ［(50.15±6.52)min vs (78.69±7.74)min, (55.67±11.41)ml vs (85.51±9.78)ml, (6.01±1.27)d vs (10.48±2.36)d］ (P<0.05). The incidence of complications in the observation group was lower than that in the control group（P<0.05）. Conclusion　Arthroscopic surgery can improve the curative effect, shorten the operative time and promote the recovery for the patients with traumatic arthritis after ankle fracture.]]> 2019/4/1 16:03:54 RAN Yan-hui 53true ［Abstract］　Objective　To investigate the effects of irbesartan combined with nifedipine on the treatment outcome, left ventricular diastolic function and quality of life in patients with essential hypertension. Methods　A total of 112 patients with essential hypertension were selected in our hospital from February 2014 to February 2017 and were randomly divided into the control group(n=53, treated with large dose of irbesartan) and the observation group(n=59, treated with regular dose of irbesartan plus nifedipine). Both of the two groups were treated for 5 months. The changes of blood pressure, cardiac function therapeutic effect and incidence of adverse reactions were compared between the two groups. Results　After treatment, the decreases of SBP and DBP in the observation group were significantly higher than those in the control group(P<0.05). The E/A ratios were significantly increased, and the other indexes of cardiac function were significantly decreased in both of the two groups. The degree of change in the observation group was significantly higher than that in the control group(P<0.05). In the observation group, 54 cases were markedly effective, 3 cases effective and 2 cases in effective. In the control group, 25 cases were markedly effective, 15 cases effective and 13 cases ineffective. The therapeutic effect of the observation group was better than that of the control group(P<0.01). The incidence of adverse reactions in the observation group(8.5%) was currently lower than that in the control group(28.3%)(P<0.05). Conclusion　Irbesartan combined with nifedipine treatment can improve the therapeutic effect for the patients with essential hypertension, and can significantly improve the patients′ left ventricular diastolic function and quality of life.]]> 2019/3/4 16:47:08 QIU Fu-mei, XIE Huai-quan, CHEN Guo-hua, et al. 52true ［Abstract］　Objective　To explore the clinical features and the related pathogenic factors of refractory purulent meningitis in children. Methods　A total of 60 cases of pediatric refractory purulent meningitis diagnosed during January 2015 and June 2017 were included in this study. The clinical data were retrospectively analyzed to study the clinical features and pathogenic factors of refractory purulent meningitis in children. Results　Of the 60 paediatric patients, 41 cases had symptoms of fever, 28 cases had meningeal irritation, 11 cases had Babinski sign(+), 12 cases had skin irritation, and 9 cases had respiratory abnormalities. The cerebrospinal fluid bacteriological examination of bacteria was positive in all of the 60 children. The most common pathogens causing bacterial meningitis in the cerebrospinal fluid cultures were N. meningitidis, S. pneumoniae and bacillus coli. After treatment, a total of 56 children were cured, 3 children with fungal meningitis were transferred to a superior hospital. 1 case of minor lesions was followed up for 6 months and no recurrence was found. Conclusion　The clinical manifestations of refractory purulent meningitis in children are mainly complicated with fever, common clinical signs such as meningeal irritation, abnormally increased leukocyte count and C-reactive protein. Such as N. meningitidis, S. pneumoniae and bacillus coli are found in CSF. Reasonable use of antibiotics should be adjusted according to the results of bacterial culture and IDSA bacterial meningitis treatment guidelines.]]> 2019/3/4 16:47:08 WANG Fei 51true ［Abstract］　Objective　To study the curative effect of abdominal transverse cleavage line small incision on oblique inguinal hernia in children. Methods　One hundred and four children with oblique inguinal hernia in our hospital were selected as the research subjects. They were randomly divided into the abdominal transverse small incision group(observation group, n=52) and the traditional operation group(control group, n=52). The operative time, intraoperative blood loss, incision length and healing time were compared between the two groups. The pain scores 1 and 3 days after operation［Child Pain Behavior Scale(FLACC)］ and postoperative complications 6 months after operation(tissue edema, infection) and recurrence rates were compared between the two groups. Results　The amount of bleeding, operation time, length of incision and the healing time in the observation group were shorter than those in the control group(P<0.05). The FLACC scores 1 day after operation in the observation group were lower than those in the control group(P<0.05). The FLACC scores in the two groups 3 days after operation were lower than those 1 day after treatment(P<0.05), and the FLACC scores of the observation group were lower than those of the control group(P<0.05). The incidence rate of complications and the recurrence rate in the observation group were lower than those in the control group(P<0.05) 6 months after operation. Conclusion　Abdominal transverse cleavage line small incision has a better curative effect on oblique inguinal hernia in children. It can reduce the recurrence rate and improve the prognosis.]]> 2019/3/4 16:47:08 LIU Ru-yi, XU Ke, ZHANG Xian-wei 50true ［Abstract］　Objective　To analyze the clinical features and CT imaging data of acute appendicitis. Methods　The clinical and CT imaging data of 62 cases with acute appendicitis proved by surgical resection and pathology in our hospital from November 2015 to October 2017 were retrospectively analyzed. Results　In the 62 cases with acute appendicitis, the appendix positions: 56 cases of common positions, 5 cases of low positions, 1 case of high position. CT findings: 4 cases were illegible by appendicular CT. The diameter of the appendixes was (1.04±0.31)cm in 58 cases among whom the diameters were larger than 6 mm in 53 cases and smaller than 6 mm in 5 cases. Appendiceal effusion occurred in 41 cases, appendix wall thickening(>2 mm) in 48 cases, appendicium calculi in 17 cases, appendicium exudation in 54 cases, cellulites in 10 cases, abscess around appendicium in 5 cases, cumulation around appendicitis in 6 cases, peritonitis in 29 cases, ascites in 9 cases, thickening of ileum in 39 cases and enlarged lymph nodes in 10 cases. In 1 case with acute appendicitis, the swelling of appendix was thickened and strengthened obviously. The surgical and pathological results: simple appendicitis was found in 8 cases, pyogenic appendicitis in 37 cases, and gangrenous appendicitis in 17 cases.The complications: perforation occurred in 9 cases, abscess formation in 5 cases, diffuse peritonitis in 11 cases and localized peritonitis in 18 cases. Conclusion　Some specific CT signs are found in acute appendicitis: enlargement of the appendix, effusion of the appendix, thickening of the wall of the appendix and the exudation around the appendix. CT has a high diagnostic value for acute appendicitis.]]> 2019/3/4 16:47:08 LIANG Shu-sheng, MO Yong-can, ZHU Yu-li, et al. 49true ［Abstract］　Objective　To compare the clinical effects between open reduction and internal fixation and nonsurgical treatment on multiple rib fractures. Methods　One hundred and twenty-six patients with multiple rib fractures in our hospital from February 2012 to October 2017 were divided into the internal fixation group(receiving open reduction and internal fixation, n=65) and the nonsurgical group(receiving nonsurgical treatment, n=61). The hospitalization time, the time of ambulation exercise, the fracture healing time, the hospitalization expenses, the pain degrees before and after treatment, the complications and pulmonary function were compared between the two groups. Results　The hospitalization time, the time of ambulation exercise and the fracture healing time in the internal fixation group were significantly shorter than those in the nonsurgical group（P<0.05）, and the hospitalization expenses in the internal fixation group were significantly higher than those in the nonsurgical group（P<0.05）. There were no significant differences in VAS scores between the two groups before surgery（P>0.05）. VAS scores in the internal fixation group were significantly lower than those in the nonsurgical group 1, 7 and 14 days after surgery（P<0.05）. The pulmonary function indexes in the internal fixation group were significantly better than those in the nonsurgical group 3 months after surgery（P<0.05）. The incidence of main complications was 6.15%（4/65） in the internal fixation group, and 18.03%（11/61） in the nonsurgical group（P<0.05）. Conclusion　Open reduction and internal fixation can obviously promote the patients′ recovery, reduce the pain and the incidence of complications in the treatment of multiple rib fractures.]]> 2019/3/4 16:47:08 WU Shao-quan, XIONG Zhen 48true ［Abstract］　Objective　To explore the effect of helicobacter pylori(Hp) infection on blood lipid metabolism and oxidative stress response in patients with acute cerebral infarction（ACI） complicated with Hp infection through the detection of malondialdehyde(MDA) and superoxide dismutase(SOD) activity. Methods　Two hundred ACI patients(139 cases of Hp infection and 61 cases of non-infection) were chosen as ACI group and 80 health examinees as control group. The detections of serum Hp-IgG antibody, serum lipid, MDA level and SOD activity, and ¹⁴C urea breath test(¹⁴C-UBT) were performed. Results　The Hp infection rate of the ACI group(69.5%) was significantly higher than that of the control group(33.8%)（P<0.01）. In the patients with Hp infection, the levels of TC, TG and LDL-C were significantly higher, and the level of HDL-C was significantly lower than those in the patients without Hp infection(P<0.01). The serum level of MDA was significantly higher and SOD activity was significantly lower in the Hp infection group than those in the Hp non-infection group（P<0.01）. The serum level of MDA was significantly higher and SOD activity was significantly lower in the Hp non-infection group than those in the control group（P<0.01）. Conclusion　Dyslipidemia and oxidative stress reaction are aggravated in the patients with ACI complicated with Hp infection, which may be the cause that aggravates the ACI disease in the patients.]]> 2019/1/31 16:31:42 ZHOU Zhong-xiang, YANG Wen-dong 47true ［Abstract］　Objective　To explore the clinical effect of alprostadil combined with Shuxuetong on chronic obstructive pulmonary disease（COPD） complicated with pulmonary hypertension(PH）. Methods　One hundred and seventy-two patients with COPD complicated with PH were selected and were randomly divided into control group, group A, group B and group C, with 43 cases in each group. All of the groups were given conventional treatment. Group A was treated with alprostadil. Group B was treated with Shuxuetong, and group C was treated with alprostadil plus Shuxuetong. The levels of serum endothelin-1(ET-1), nitric oxide(NO), fibrinogen(FIB) and D-dimer(DD) were detected before treatment and 2 weeks after treatment, and the pulmonary function, average pulmonary artery pressure(mPAP) and clinical effects were assessed. Results　The FEV1/FVC(%)［(64.86±1.16)%］ and SGRQ scores［(79.27±4.09)points］ in group C were significantly higher than those in the other 3 groups(P<0.05). The mPAP of group C［(30.15±1.88)mmHg］ was lower than those of the other 3 groups(P<0.05). After treatment, the levels of ET-1［(51.70±7.14)ng/L］, FIB［(3.51±0.37)g/L］, and DD［(140.35±9.67)mg/L］ in group C were lower than those in the other 3 groups(P<0.05). After treatment, the concentration of blood NO in group C［(40.56±3.71)μmol/L］ was higher than those in the other 3 groups(P<0.05). Conclusion　Alprostadil combined with Shuxuetong can significantly improve the lung function, reduce the pulmonary arterial pressure, and improve the endothelium cell and coagulation status in the patients with COPD complicated with PH.]]> 2019/1/31 16:31:42 HU Yao-wu, QIAN Hai-Yan, HU Xiao-ying, et al. 46true ［Abstract］　Objective　To explore the clinical effect of Huatan Tongluo decoction on acute ischemic stroke in elderly patients. Methods　Fifty-six patients with acute ischemic stroke were selected in our hospital from October 2016 to October 2017 and were randomly divided into observation group and control group, with 28 cases in each group. The patients in the control group received routine western medicine, while the patients in the observation group were treated with Huatan Tongluo decoction plus the same treatment as the control group. All the patients were treated for 14 days, and the clinical effect was compared between the two groups. Results　Compared with those before treatment in the two groups, the hemorheological indicators were significantly improved after treatment(P<0.05), and the improvements of the indicators in the observation group were better than those in the control group(P<0.05). In the observation group, 6 cases were cured, 12 cases markedly improved, 7 cases improved, and 3 cases invalid. In the control group, 3 cases were cured, 9 cases markedly improved, 5 cases improved, and 11 cases invalid. The total effective rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion　Huatan Tongluo decoction is effective in treatment of the elderly patients with acute ischemic stroke.]]> 2019/1/31 16:31:42 YANG Qiong 45true ［Abstract］　Objective　To explore the clinical effect of Jiawei Sini decoction on heart-kidney yang deficiency syndrome of chronic heart failure. Methods　One hundred patients with heart-kidney yang deficiency syndrome of chronic heart failure in our hospital from January 2016 to February 2017 were randomly divided into control group and observation group, with 50 cases in each group. The control group was given conventional western medicine treatment, and the observation group was given the same treatment as the control group plus Jiawei Sini decoction. Both of the two groups received treatment for two months(two courses of treatment). The clinical curative effect, cardiac function, Traditional Chinese Medicine(TCM) syndrome score and adverse drug reaction were compared between the two groups after treatment. Results　After 2 courses of treatment, the total efficiency, SV and LVEF in the observation group were significantly higher than those in the control group. LVSEd and TCM syndrome scores in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the adverse drug reaction rate between the two groups(P>0.05). Conclusion　Jiawei Sini decoction can improve the therapeutic effect of heart-kidney yang deficiency syndrome of chronic heart failure, improve the clinical symptoms and cardiac function, and cause less adverse reactions.]]> 2019/1/31 16:31:42 BAI Pei-jun, XU Wen-jing 44true ［Abstract］　Objective　To explore the value of energy spectral computed tomography(CT) in qualitative diagnosis of metastatic lymph nodes of different differentiated gastric cancers. Methods　The energy spectral CT imaging data of 50 patients with gastric cancer confirmed by gastroscope pathological examination were analyzed. Normalized iodine concentrations(NIC) was measured in the arterial and venous phases of gastric lymph nodes, and compared with the results of surgical pathology. Results　Among the 50 cases of gastric adenocarcinoma, 38 cases were proved to have lymph node metastasis by operation and pathology of gastric cancer, and 12 cases had no lymph node metastasis. There were 83 metastatic lymph nodes confirmed by pathology, including 34 metastatic lymph nodes of high and moderate differentiation adenocarcinoma, 49 metastatic lymph nodes of low differentiation adenocarcinoma and 31 non-metastatic lymph nodes. By using NIC and energy spectrum curve, the sensitivity of energy spectral CT in diagnosis of lymph node metastasis of gastric cancer was 90.4%(75/83), with a specificity of 87.1%(27/31), and the diagnostic coincidence rate was 89.5%(102/114). There were significant differences in the NIC between metastatic lymph nodes and non-metastatic lymph nodes in arterial and venous phases of highly and moderately differentiated gastric adenocarcinoma(P<0.05). Conclusion　Energy spectral CT plays an important role in the qualitative diagnosis of lymph nodes of different differentiated gastric cancers, which can provide help for the clinical diagnosis and treatment of gastric cancer.]]> 2019/12/30 10:12:41 ZHU Li-li, ZHENG Yu- fei, XU Hui 43true ［Abstract］　Objective　To observe the effects of budesonide aerosol inhalation on lung fanction, blood gas index, inflammatory factors and clinical symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods　From January 2016 to August 2016, 100 AECOPD patients in our hospital were randomly divided into observation group and control group, with 50 cases in each group by randon number table method. Both of the two groups were given anti-infection, oxygen, expectorant and bronchodilator therapy, and the observation group was given additional budesonide aerosol inhalation therapy for 7 days. The changes of lung function, blood gas index, inflammatory factors and clinical symptomatic remissions were compared between the two groups. Results　After treatment, the values of FEV1%pred, FEV1/FVC, PaO₂ and pH in the observation group were significantly higher than those in the control group(P<0.05) and the serum levels of IL-8, IL-6, IL-32 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05); the scores of cough, expectoration and lung auscultation in the observation group were significantly lower than those in the control group(P<0.05). Conclusion　Budesonide aerosol inhalation can further alleviate the clinical symptoms of the patients with AECOPD,and improve their lung function and blood gas.]]> 2019/12/30 10:12:41 LI Xiao-ling, YAN Min-li, HOU Lan-lan, et al. 42true ［Abstract］　Objective　To investigate the effect of transverse circular compression suture of lower uterine segment on treating the hemorrhage of placenta dissection surface in the cesarean section of placenta previa. Methods　Sixty-seven patients with hemorrhage of placental dissection surface during cesarean section of placenta previa who received hemostasis with traditional “8” suture method in our hospital from January 2017 to June 2017 were selected as the control group. Other sixty-seven patients with hemorrhage of placental dissection surface during cesarean section of placenta previa who received transverse circular compression suture of lower uterine segment in our hospital from July 2017 to December 2017 were selected as the observation group. The operation time, the amount of intraoperative blood loss, the amount of bleeding after operation for 24 hours, the oxytocin usage, the postoperative complications and the hysterectomy rate were observed and compared between the two groups. Results　The operation time of the observation group was significantly shorter than that of the control group(P<0.01). The amount of intraoperative blood loss and the bleeding volume after operation for 24 hours in the observation group were significantly less than those in the control group(P<0.01). There was no significant difference in the oxytocin usage between the two groups(P>0.05). There were no significant differences in the incidence rates of late postpartum hemorrhage, poor uterine involution and postoperative incision infection between the two groups(P>0.05). The rate of hysterectomy in the observation group(0.00%) was significantly lower than that in the control group(8.96%)(P<0.05). Conclusion　Transverse circular compression suture of lower uterine segment is effective in treatment of hemostasis after the bleeding of placenta dissection surface during cesarean section of placenta previa and is suitable for clinical application.]]> 2019/12/30 10:12:41 LIU Wei, LIU Ping, WANG Yun-xia 41true ［Abstract］　Objective　To explore the influencing factors of parenteral nutrition(PN)-associated cholestasis(PNAC) in critically ill premature infants. Methods　Three hundred premature infants over 14 days of gestational age in the Neonatal Intensive Care Unit of Boai Hospital were selected as the study subjects from January 2017 to December 2017. They were divided into non- PNAC group(n=215) and PNAC group(n=85) according to whether or not PNAC occurred. The clinical situations and nutritional factors of the premature infants were compared between the two groups and the risk factors were analyzed by non-conditional Logistic regression analysis. Results　There were significant differences in neonatal infections, anemia, mechanical ventilation, fasting time, quantity of total fat and milk, and total calorie between the two groups(P<0.05). Multivariate analysis showed that neonatal infections(OR=2.352), long fasting time(OR=1.263), long duration of PN(OR=1.854) and high proportion of amino acid calorie(OR=2.865), and high proportion of fat milk calorie(OR=1.854) were the risk factors of PNAC. The protective factor was intake of high calorie through mouth(OR=0.025). Conclusion　Neonatal infections, long duration of PN and long fasting time are the risk factors of PNAC in premature infants.]]> 2019/11/28 12:01:08 FENG Ming-hua, WANG Xia, LAI Chun-hua 40true ［Abstract］　Objective　To compare the clinical effects of tacrolimus(TAC) and cyclophosphamide(CTX) on treatment of children with steroid-resistant nephrotic syndrome. Methods　Forty children with steroid-resistant nephrotic syndrome were enrolled in the People′s Hospital of Meizhou City between January 2012 and January 2018 and were divided into treatment group(n=20) and control group(n=20) according to different medications. The treatment group received glucocorticoid plus TAC, while the control group was treated with glucocorticoid plus CTX. The levels of urinary protein, albumin and cholesterol, edama of lower extremity and the adverse drug reactions including renal toxicity, bone marrow suppression and gastrointestinal disorders were compared between the two groups. Results　There was significant difference in urinary protein, albumin and edama of lower extremity between the treatment group and in the control group after six months treatment(P<0.05), however, there was no significant difference in the cholesterol between the two groups(P>0.05). The therapeutic effects in the treatment group was better than that in the control group and the incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group 6 months after treatment(P<0.05). There were no significant differences in the observation indexes between the two groups 12 months after treatment(P>0.05). Conclusion　The short-term clinical effects of TAC are slightly better than those of CTX on treatment of children with steroid-resistant nephrotic syndrome and TAC has less adverse drug reactions.]]> 2019/11/28 12:01:08 HUANG Xiao-hong, LIU Jia-lin, ZHANG Yu-hua 39true ［Abstract］　Objective　To analyze the clinical effects of plasmakinetic enucleation of prostate（PKEP） and plasmakinetic resection of prostate（PKRP） on benign prostatic hyperplasia(BPH). Methods　One hundred and seventy cases of BPH in the People′s Hospital of Tanghe County from April 2013 to April 2016 were divided into observation group(n=85) and control group(n=85) according to different surgical methods. The patients in the control group were treated with PKRP, and the patients in the observation group were treated with PKEP. The perioperative indicators, postoperative complications and long-term outcomes were observed and compared between the two groups. Results　The time of bladder irrigation, the time of operation, the indwelling time of urethral catheter, and the time of postoperative hospitalization in the observation group was significantly shorter than that in the control group（P<0.05）. The amount of intraoperative bleeding in the observation group was significantly less than that in the control group（P<0.05）. The volume of prostate glands resected in the observation group was significantly larger than that in the control group(P<0.05). There was no significant difference in the incidence of complications between the observation group(11.8%) and the control group(7.1%)（P>0.05）. There were no significant differences in Q_max, RUV, IPSS and QOL between the two groups 90 days after treatment(P>0.05). Conclusion　Compared with PKRP, PKEP has the advantages of shorter operation time, less intraoperative bleeding and more thorough resection of the prostate glands for the treatment of BPH, and the complications of PKEP are not increased significantly. It is worth to be applied widely.]]> 2019/11/28 12:01:08 LI Wan-quan 38true ［Abstract］　Objective　To analyze the risk factors causing anastomotic leakage in colorectal cancer patients after surgery. Methods　The clinical data of 459 colorectal cancer patients who had radical resection of colorectal cancer in our hospital from January 2006 to June 2018 were retrospectively analyzed. Univariate analysis and multivariate Logistic regression analysis were performed to analyze the risk factors causing anastomotic leakage after surgery. Results　The incidence of anastomotic leakage was 9.80%（45/459）. Multivariate Logistic regression analysis showed that age（OR=2.815）, preoperative concurrent diabetes（OR=4.872）, preoperative concurrent hypoproteinemia（OR=3.258） and the distance of the tumors from the anal verge（OR=4.153） were the risk factors of anastomotic leakage occurrence in colorectal cancer patients after surgery. Conclusion　Age, preoperative concurrent diabetes, preoperative concurrent hypoproteinemia and the distance of the tumors from the anal verge are the risk factors of anastomotic leakage occurrence after colorectal cancer surgery. The influence of these factors should be taken into careful consideration during the perioperative period, and the appropriate preventive measures should be taken actively.]]> 2019/11/28 12:01:08 ZENG Qing-zhi, HUANG Qi-kui, DENG Jie-jian 37true ［Abstract］　Objective　To investigate the effects of Kinect somatosensory game on lower limb functional rehabilitation training in elderly patients with hemiplegia of cerebrovascular disease during convalescent period. Methods　Sixty patients with hemiplegia of cerebrovascular disease during convalescent period were randomly divided into the control group and the somatosensory group, with 30 cases in each group. The control group received routine rehabilitation exercise spontaneously. The somatosensory group spontaneously carried out daily rehabilitation exercises with somatosensory game intervention under the same environmental configuration. After the intervention of 35 days, the Physical Exercise Rating Scale(PARS-3) and activities of daily living(ADL) ability and limb movement function were evaluated were performed. Results　After the intervention of 35 days, the exercise grade scores of the somatosensory group were significantly higher than those of the control group(P<0.01). The ADL function and limb movement function were improved after convalescent rehabilitation training in both groups. The ADL and limb movement function evaluation scores of the patients in the somatosensory group were significantly higher than those of the patients in the control group(P<0.05). Conclusion　Kinect somatosensory game intervention can make elderly hemiplegic patients participate in rehabilitation training more actively in the convalescent rehabilitation exercise, and effectively improve the effect of rehabilitation training.]]> 2019/10/30 10:56:24 PU Zhi-qing, QIAO Jia-hao, LIN Li-peng, et al. 36true ［Abstract］　Objective　To observe the effects of recombinant human interferon α-2b combined with Baofukang suppository in patients with chronic cervical erosion and human papillomavirus(HPV) infection. Methods　Ninety-eight high-risk patients with chronic cervical erosion and HPV infection admitted to our hospital from May 2013 to August 2017 were divided into two groups according to different treatment methods: the single drug group(treated with Baofukang suppository) and the combination drug group(treated with Baofukang suppository+recombinant human interferon α-2b). The HPV clearance efficacy, cervical erosion-like changes and immune function changes were compared between the two groups. Results　The improvements of HPV clearance and cervical erosion-like change in the combination drug group were better than those in the single drug group（P<0.05）. After treatment, the level of tumor necrosis factor-α(TNF-α) was lower and IL-6 was higher in the combination drug group than those in the single drug group(P<0.01). Conclusion　Recombinant human interferon α-2b combined with Baofukang suppository can improve the efficacy of HPV scavenging and cervical erosion-like changes and immune function in the patients with chronic cervical erosion and HPV infection, which is suitable for clinicl promotion.]]> 2019/10/30 10:56:24 JIANG Hai-fang 35true ［Abstract］　Objective　To observe the therapeutic effect of butylphthalide injection combined with edaravone on acute cerebral infarction. Methods　Eighty cases of acute cerebral infarction treated in our department from January 2016 to June 2017 were randomly divided into the combination group and the edaravone group, with 40 cases in each group. On the basis of routine treatment, the combination group was treated with butylphthalide injection combined with edaravone and the edaravone group was treated with edaravone. Both of the two groups were treated for 2 weeks and two weeks was a course of treatment. The changes of the National Institutes Health Stroke Scale(NIHSS) scores, the clinical therapeutic effect and the volume of the cerebral infarction were compared between the two groups before and after treatment. Results　Compared with those before treatment, the NIHSS scores were significantly lower in the two groups after treatment(P<0.05), and the NIHSS scores of the combination group were significantly lower than those of the edaravone group after treatment（P<0.05）. In the combination group, 10 cases were cured, 11 remarkably effective, 14 effective, 3 ineffective and 2 exacerbated. In the edaravone group, 4 cases were cured, 7 remarkably effective, 13 effective, 10 ineffective and 6 exacerbated. The therapeutic effect of the combination group was better than that of the edaravone group（P<0.05）. Compared with those before treatment, the volumes of the cerebral infarction in the two groups reduced greatly（P<0.05）, and the reduction volume of the combination group was significantly greater than that of the edaravone group（P<0.05）. Conclusion　Butylphthalide injection combined with edaravone can improve the quality of life and the effective rate, and reduce the volume of infarction in the patients with acute cerebral infarction.]]> 2019/10/30 10:56:24 LUO Wei-li, LIU Te-jiong, LIN Zhi-jia 34true ［Abstract］　Objective　To evaluate the effects of bilateral craniotomy with different surgical timings and modes on traumatic multiple intracranial hematoma(TMIH). Methods　One hundred cases of TMIH were collected in our hospital from March 2011 to June 2017 and were divided into the observation group and the control group according to the date(odd-even day) of admisson, with 50 cases in each group. The control group received staged bilateral craniotomy treatment, and the observation group received phase Ⅰ bilateral craniotomy treatment. The clinical effects and GOS scores were compared between the two groups. Results　In the control group, good recovery was in 16 cases, mild disability in 25 cases, severe disability in 6 cases, persistent vegetative state in 2 cases and death in 1 case. In the observation group, good recovery was in 28 cases, mild disability in 20 cases, severe disability in 1 case, and persistent vegetative state in 1 case. The excellent and good rate of the observation group(96.0%) was significantly higher than that of the control group(82.0%)（P<0.05）. The clinicl effect of the observation group was better than thit of the cortrol group（P<0.05）. Before treatment, there were no significant differences in GOS scores between the two groups［(2.15±0.64)points vs (2.18±0.59)points］ (P>0.05). After treatment, the GOS scores of the observation group［(4.52±0.83)points］ were significantly higher than those of the control group［(3.37±0.97) points］ （P<0.05）. Conclusion　Phase Ⅰ bilateral craniotomy is more effective than staged bilateral craniotomy in the treatment of TMIH. Phase Ⅰ bilateral craniotomy is worth applying in clinic.]]> 2019/10/30 10:56:24 FENG Ya-dong 33true ［Abstract］　Objective　To analyze the clinical and computed tomography(CT) imaging characteristics of coronavirus disease 2019(COVID-19). Methods　The epidemiological history, laboratory examination, chest CT imaging characteristics of 61 COVID-19 patients admitted to our hospital from January 20, 2020 to March 12, 2020 were retrospectively analyzed. Results　Among the 61 cases, 49 cases(80.33%) had a short history of residence in Hubei area, and 7 cases(11.48%) did not travel to other places, but had a history of close contact; 5 cases(8.20%) had not been to the epidemic area before the onset of the disease, but had a history of taking high-speed train or aircraft and other means of transportation. The main clinical manifestations of the patients were fever and cough, and 6 patients had no any symptoms. Laboratory test results showed that the levels of leukocytes, lymphocytes, alanine aminotransferase(ALT), aspartate aminotransferase(AST), creatine kinase(CK) and lactate dehydrogenase(LD) in the 61 patients were mostly normal, while the level of hypersensitive C-reactive protein(hs-CRP) was mainly increased. COVID-19 lesions could be found in any lung lobe. In the early stage, they could only appear in one lung segment or lobe, but they could also occur in both lungs. The typical pulmonary lesions were located in the middle and outer long axis of the lung lobes parallel to the chest wall. The CT imaging features were mainly ground glass opacity, paving stone signs, air bronchial signs, and vascular bundle thickening change. Lung consolidation might be seen in the progressive stage. After 3 days of treatment, the pulmonary lesions were gradually absorbed and dissipated in 45 cases(73.77%). Sixteen cases(26.23%) were reexamined for the second time after treatment using chest CT, and the results showed that the lesions increased to different degrees in the patients, however these lesions were gradually absorbed and dissipated when the patients were reexamined for the third and(or) for the fourth time after treatment using chest CT. In the process of focal absorption, the ground glass opacity and some patchy consolidation shadows became lighter and smaller. Twenty-three cases(37.70%) developed lung fibrous cord shadows in late lung absorption; six cases(9.83%) had thickened pulmonary lobular septa; eleven cases(18.03%) had subpleural arc shadows; one case(1.63%) had bronchiectasis in the middle lobe of the right lung and the lingual segment of upper lobe of the left lung; five cases(8.20%) had thickened pleural adhesions, and the pulmonary lesions were completely absorbed in 3 cases(4.92%). Conclusion　CT imaging examination is of great value in the diagnosis and prognosis evaluation of COVID-19, and provides support and reference for clinical treatment.]]> 2020/9/30 16:48:19 ZHANG Xiao-ping, XU Jing, XU Ming-yue, et al. 32true ［Abstract］　Objective　To analyze the deafness-associated gene mutation of 6590 neonates in Guangxi from June 2016 to December 2018, so as to provide scientific evidence for prevention and control of deafness-associated birth defects of the local newborns. Methods　A total of 6 590 neonates delivered in the Department of Obstetrics, the People′s Hospital of Guangxi Zhuang Autonomous Region from June 2016 to December 2018 were selected to extract deoxyribonucleic acid(DNA) from cord blood. The mutation sites of the four deafness genes(GJB2, SLC26A4, GJB3 and mitochondrial DNA12SrRNA) were screened by using the crystal core 15 genetic deafness gene detection kit. Results　A total of 156 carriers with deafness gene mutation were detected, and the total mutation rate was 2.37%. The mutation rates from high to low were GJB2>SLC26A4>mitochondrial DNA12SrRNA>GJB3, accounting for 48.72%, 34.62%, 14.10% and 2.56% respectively. There was no statistically significant difference in deafness gene mutation composition ratio between male and female infants(P>0.05). There was no statistically significant difference in the composition ratio of deafness gene mutation among different years(P>0.05). Conclusion　The neonatal deafness gene mutation carrying rates in Guangxi during 2016 and 2018 are similar to those in the previous reports. No differences are found in the composition ratios of mutation deafness gene between genders and among different years.]]> 2020/9/30 16:48:19 ZHANG Chun, ZHANG Ji-hong, LU Zhen-zhen 31true ［Abstract］　Objective　To explore the clinical effect of applying elastic intramedullary needle(ESIN) on treatment of long bone fractures of lower limbs in children. Methods　Thirty-four children with long bone fractures of lower limbs treated in our hospital from January 2013 to December 2019 were selected as the research subjects. The 34 patients were divided into observation group and control group according to the time sequence of admission and different operation methods, among whom 17 cases receiving open reduction and plate screw internal fixation during January 2013 and February 2017 were taken as the control group, and the other 17 cases receiving closed reduction and ESIN fixation during March 2017 and December 2019 were taken as the observation group. The treatment effects were compared between the two groups. Results　Both groups were regularly followed up for 6 to 24 months. In the observation group, when the plaster was removed 4 weeks after operation, the formation of callus of bone could be seen on the fracture ends by X-ray, and no infection, looseness and skin allergy were found at the nail holes of the intramedullary nails. The average healing time of the fractures in the observation group was (43.25±5.36)days. No fracture nonunion and delayed union, no deformity of fracture alignment, no shortening of the affected limbs and no infection of the internal fixations were found. Six months after operation, all the children were followed up and their limb activity returned to normal, and the joint activity around the fractures was not limited. In the control group, the average healing time of the fractures was (70.49±8.41)days; three cases had delayed unions, and 2 cases had internal fixation infections, and the fractures healed after reoperation; no deformity of fracture alignment and limb shortening deformity were found. The operation time, hospitalization time and the fracture healing time of the observation group was significantly shorter than that of the control group(P<0.05). The amount of bleeding in the observation group was significantly less than that in the control group(P<0.05). The clinical effect of the observation group were significantly better than those of the control group(P<0.05). Conclusion　The application of elastic intramedullary needle is significantly effective in treatment of long bone fractures of lower limbs in children, which is worthy of clinical promotion.]]> 2020/9/30 16:48:19 ZHANG Min, FENG Xi-guang, CHEN Jun-zhu, et al. 30true ［Abstract］　Objective　To observe the clinical effect of fire-needle therapy combined with filiform-needle acupuncture on treatment of early-stage acute mastitis in lactation. Methods　From May 2018 to March 2019, sixty patients with acute mastitis during their lactations were divided into observation group and control group according to the random number table method, with 30 cases in each group. Both groups were given breast dredging massage. The observation group received fire-needle therapy combined with filiform-needle acupuncture, and the control group was treated with oral cefaclor. The therapeutic effect was evaluated 5 days after treatment. The scores of main symptoms and signs, the time of pain disappearance, the time of mass disappearance and the changes of hematology indexes were compared between the two groups. Results　After treatment, the scores of main symptoms and signs in the observation group were significantly lower than those in the control group(P<0.05), and the time of pain and mass disappearance in the observation group was significantly shorter than that in the control group(P<0.01). After treatment, the white blood cell(WBC) count and the percentage of neutrophil count(NEUT%) were decreased significantly in the two groups(P<0.01), but there were no significant differences between the two groups(P>0.05). No adverse reactions occurred in both groups. Conclusion　Fire-needle therapy combined with filiform-needle acupuncture is effective in treatment of early-stage acute mastitis in lactation. The combined treatment can quickly alleviate breast pain, eliminate masses and discharge breast milk in time, which is worthy of clinical application.]]> 2020/9/2 15:08:59 ZHOU Jing, GONG Tian-liu, HE Zhou 29true ［Abstract］　Objective　To observe the clinical effect of micro-titanium plate modified single-door cervical spinal canal enlargement laminoplasty on multi-segmental cervical spondylotic myelopathy(MCSM). Methods　Eighty-two MCSM patients admitted to the Department of Orthopedics of Nanyang Second General Hospital from August 2016 to September 2018 were enrolled in this study. The patients were divided into observation group(n=43) and control group(n=39) by random number table method. The observation group was treated with micro-titanium plate modified single-door cervical spinal canal enlargement laminoplasty, and the control group received a conventional single open-door laminoplasty through posterior approach. The operation time, the first postoperative rehabilitation training time, the intraoperative blood loss, the postoperative drainage volume, the treatment efficiency and postoperative complications were compared between the two groups. Results　The first postoperative rehabilitation training time of the observation group was significantly shorter than that of the control group(P<0.01). In the observation group, 33 cases were markedly effective, 9 cases effective and 1 case ineffective. In the control group, 19 cases were markedly effective, 14 cases effective and 6 cases ineffective. The clinical effect of the observation group was better than that of the control group(P<0.05). The incidence of postoperative complications in the observation group was significantly lower than that in the control group(P<0.05). Conclusion　Micro-titanium plate modified single-door cervical spinal canal enlargement laminoplasty has good curative effect, less complications and good prognosis in MCSM patients, and can be widely applied in the clinical surgical treatment.]]> 2020/9/2 15:08:59 YANG Yu-qiang, QUAN Xiao-li, WANG Liu-yu 28true ［Abstract］　Objective　To explore the safety protection of medical staff and the safety management of patients with corona virus disease 2019(COVID-19) complicated with acute appendicitis during perioperative period. Methods　The surgical program, intraoperative and postoperative protective measures of the medical staff and the patient′s management of a case of COVID-19 complicated with acute appendicitis admitted to our hospital in February 2020 were summarized. Results　The patient received open appendectomy and recovered well after the operation. COVID-19 did not occur in the medical staff. Conclusion　On the premise of good protection, open surgery can be performed on COVID-19 patients with acute appendicitis, which is safe for both the medical staff and the patients.]]> 2020/9/2 15:08:59 RUI Qing-feng, SUN Zhen-yang, LIU Yun-le, et al. 27true ［Abstract］　Objective　To investigate the clinical value of reticulocyte hemoglobin content(Ret-He) combined with iron metabolism parameters in diagnosis of iron deficiency anemia(IDA) in adults. Methods　One hundred and sixty-five patients were selected from the Department of Hematology of Haimen People′s Hospital during November 2018 and October 2019. The red blood cell parameters［hemoglobin(Hb), mean corpuscular volume(MCV), mean corpuscular hemoglobin content(MCH)］, reticulocyte parameters(Ret-He), iron metabolism parameters［serum iron(SI), serum ferritin(SF)］ and inflammatory markers［C-reactive protein(CRP)］ were detected in the patients. The research subjects were divided into four groups according to different hemoglobin levels and bone marrow iron staining results: iron deficiency anemia(IDA) group(n=53), non-iron deficiency anemia(NIDA) group(n=34), iron-deficiency non-anemia group(n=35) and control group(n=43). The differences of the above-mentioned indexes were compared among the four groups and the effect of inflammation was also considered. The receiver operating characteristic(ROC) curves of IDA and Ret-He+SI+SF were drawn to diagnose IDA by the individual indicator and the joint indicator respectively. The sensitivities and the specificities of each indicator and Ret-He+SI+SF were calculated. Results　The levels of the parameters in the IDA group were significantly lower than those in the NIDA group, the iron-deficiency non-anemia group and the control group(P<0.05). The levels of SI and SF in the NIDA group were significantly higher than those in the iron-deficiency non-anemia group and the control group(P<0.05). The levels of Ret-He, Hb, MCV, MCH, SI and SF in the iron-deficiency non-anemia group were significantly lower than those in the control group(P<0.05). There were significant differences in the levels of SI and SF in the patients′ blood between the inflammatory group and the non-inflammatory group(P<0.05), while there were no significant differences in the levels of Ret-He, Hb, MCV and MCH between the two groups(P>0.05). The results of ROC curve analysis showed that the cut-off value of Ret-He for diagnosing IDA was 28.8 pg, with the sensitivity being 91.1%, the specificity being 90.9%, and the area under the curve(AUC) being 0.947(95%CI: 0.875～0.984). The sensitivity and the specificity of Ret-He+SI+SF in diagnosing IDA were 92.7% and 93.5% respectively, and the AUC was 0.959(95%CI: 0.900～0.988). Conclusion　Ret-He combined with SI and SF has a higher clinical value in diagnosis of IDA, and its comprehensive diagnosis efficiency is better than the diagnosis efficiency of Ret-He, Hb, MCV, MCH, SI and SF alone for diagnosis of IDA.]]> 2020/8/3 9:08:34 ZHOU Liang, GUO Jian-hui, ZHANG Xiao-peng 26true ［Abstract］　Objective　To investigate the efficacy and safety of deep-venous catheter drainage in treatment of pleural effusion after burns. Methods　From January 2010 to December 2018, 27 burned patients complicated with pleural effusion who underwent deep-venous catheter drainage were retrospectively analyzed. Continuous drainage of pleural effusion by pleural puncture and indwelling venous catheter was performed on the patients with moderate to large amount of pleural effusion. The daily discharge, the time of indwelling venous catheter, the therapeutic effect and complications were observed. Results　A total of 47 times of puncture and catheterization were performed on 27 patients among whom 19 cases needed catheterization in bilateral chest wall while 8 cases needed unilateral drainage, and one case needed one more catheterization because of blockage of the catheter. After the catheterization, the symptoms of the patients were relieved, and their heart rate and breathing slowed down, and their chest tightness and dyspnea were gradually improved. The pleural effusion tests showed that all of the pleural effusion was transudate. The pleural effusion was pale red or yellowish, transparent and non-coagulable. The daily discharge was 80～960 ml, with an average of (373.42±125.76)ml. The drainage time ranged from 3 to 12 days, with an average of (7.84±2.03)days. After drainage, the pleural effusion was significantly reduced or completely absorbed in all the cases. No empyema occurred. One case was positive in catheter tip culture, and one case died of multiple organ failure. Conclusion　Deep-venous catheter is safe and reliable in the drainage of pleural effusion secondary to burns, with less damage and definite curative effect, and can be widely used in burned patients.]]> 2020/8/3 9:08:34 NIU Zhan-guo, WAN Li, CHEN Xiao-wu, et al. 25true ［Abstract］　Objective　To analyze the retrospective study of laparoscopic surgery and conventional laparotomy on the patients with uterine fibroids, and to explore the effects of different operation methods on stress response and postoperative complications of the patients with uterine fibroids. Methods　From May 2016 to June 2018, 36 patients with uterine fibroids were selected as the observation group receiving laparoscopic surgery and other 36 uterine fibroid patients as the control group receiving open surgery. The preoperative and postoperative changes of cortisol(Cor), norepinephrine(NE), C-reactive protein(CRP), interleukin-6(IL-6), gastrin and prothrombin time(PT) were compared between the two groups. The operative complications were compared between the two groups. Results　The postoperative levels of Cor, NE, CRP, IL-6, gastrin and PT in the observation group were significantly lower than those in the control group(P<0.05), and the incidence of postoperative complications in the observation group was significantly lower than that in the control group, with statistically significant differences between the two groups(P<0.05). Conclusion　Compared with conventional open surgery, laparoscopic surgery can reduce the postoperative stress response and the incidence of postoperative complications in the patients with uterine fibroids.]]> 2020/8/3 9:08:34 LIU Yan, YAN Jun-yuan, CHENG Shao-mei, et al. 24true ［Abstract］　Objective　To analyze the imaging features of computed tomography(CT) and magnetic resonance imaging(MRI) in active ankylosing spondylitis(AS) and their guiding significances in clinical diagnosis and treatment. Methods　The data of 48 patients with AS spinal involvement diagnosed by the department of rheumatology of our hospital from June 2015 to December 2018 were retrospectively analyzed. All the patients had been clinically diagnosed with AS for many years, with recent lumbar pain aggravation, and underwent MRI and CT examinations within 2 weeks after the onset of symptoms. The diagnostic characteristics of the two methods were evaluated. Results　Among the 48 AS patients, CT examination showed that 28 cases had vertebral margin bone hyperplasia, and that 25 cases had “square vertebra” in the vertebral body, and that 8 cases had“ bamboo” spinal column and that 21 cases had vertebral small arthritis among whom 5 cases had bone junction of vertebral facet joint and 11 cases had narrow vertebral space and increased density. MRI was performed in 11 cases of thoracic vertebrae and 39 cases of lumbar vertebrae, among whom MRI examination showed that T1WI low signal, T2WI and pressure fat high signal changes in the anterior and posterior upper corners of vertebral body in 18 cases, that T1WI low signal,T2WI and pressure fat high signal changes of the entire and partial vertebral bodies in 30 cases, that uneven structure of nucleus pulposus and decreased signal and decreased height of intervertebral disc indicated by T2WI of intervertebral disk in 11 cases and that T1WI low signal,T2WI and pressure fat high signal of local bone and peripheral synovium of facet joints in 21 cases. Conclusion　Both MRI and CT have certain characteristics on the examination of active ankylosing spondylitis, but MRI examination has more characteristic for the disease, so MRI examination should be preferred.]]> 2020/7/3 15:01:52 LI Wei-chao 23true ［Abstract］　Objective　To explore the prenatal diagnosis and clinical evaluation of fetal megabladder. Methods　From March 2016 to June 2019, 13 cases of pregnant women with fetal megabladder were collected for clinical data evaluation, including ultrasonic diagnosis of fetal megabladder, genetic consultation, prenatal diagnosis and so on. Ultrasound was reexamined every 3～4 weeks until delivery. Results　Ten cases were diagnosed at 11～14 weeks of gestation and three cases at 15～39 weeks of gestation. Eight cases were performed prenatal diagnosis among whom 2 cases had chromosome karyotype abnormalities, including 1 case of trisomy 18 and 1 case of trisomy 13. The gene microarrays of 2 cases were found with unknown pathogenicity in some gene fragments. In 1 case with normal karyotype and gene microarray, the missense mutation of ACTG2 gene, c.769C>T, was found to be pathogenic variation by whole exome gene sequencing. Among the 13 cases, 7 cases were diagnosed with double hydronephrosis and ureteral dilatation by ultrasound, while the remaining 6 cases were associated with other abnormalities, such as cervical hydrocystic tumor, midgut hernia, systemic skin edema, hydrocephalus, evagination of viscera, single ventricle, and absence of radius on one side. Among the 13 fetuses with large bladders, labor was induced in 11 cases among whom 5 cases were followed up until receiving directly induced labor in the middle pregnancy, and pathological diagnosis was performed on 3 cases, including 1 case with prune-belly syndrome,1 case with urethral atresia and 1 case with posterior urethral valve. Two fetuses were retained in pregnancy by their mothers until they were born. After the birth of the 2 fetuses, ultrasound and cystoscopy confirmed that they had posterior urethral valves. After the posterior urethral valve ablation, they could urinate normally. Conclusion　The prognosis of fetal megabladder is poor. Prenatal ultrasound and prenatal diagnosis are helpful to clarify the causes of fetal megabladder, which is of great significance for clinical case analysis and reproductive guidance.]]> 2020/7/3 15:01:52 YI Feng-mei, FENG Zong-hui, CHEN Yan, et al. 22true ［Abstract］　Objective　To investigate the clinical effect of montelukast on immunoglobulin A(IgA) vasculitis in children and its effect on immune function. Methods　Eighty children with IgA vasculitis admitted to the pediatric department of our hospital from June 2018 to June 2019 were selected as the research subjects and were divided into observation group(n=40) and control group(n=40) according to the random number table method. The control group received routine comprehensive treatment, and the observation group received the same treatment as the control group plus montelukast. The clinical efficacy, the time of clinical symptom disappearance and the changes of immune function indexes were compared between the two groups. Results　(1)The total effective rate of the observation group(95.00%) was significantly higher than that of the control group(77.50%)(P<0.05). (2)The time of clinical symptom disappearance in the observation group was significantly shorter than that in the control group(P<0.05). (3)Before treatment, there was no significant difference in each immune function index between the two groups(P>0.05). Compared with those before treatment, the levels of CD4⁺ and CD4⁺/CD8⁺ were significantly increased and the level of CD8⁺ was significantly decreased in the observation group and the control group after treatment, and the improvement of immune function indexes except CD3⁺ in the observation group was significantly better than that in the control group(P<0.05). Conclusion　Montelukast is effective in treatment of IgA vasculitis in children. It can effectively relieve the clinical symptoms and improve the immune function, and is worthy of clinical application.]]> 2020/7/3 15:01:52 ZHAO Xin, DONG De-xing 21true ［Abstract］　Objective　To analyze the clinicopathological features and computed tomography(CT) manifestations of parotid adenolymphoma, and to evaluate the diagnostic value of CT in the disease. Methods　A total of 54 patients with parotid adenolymphoma confirmed by surgery and pathology in our hospital from January 2010 to January 2020 were selected as the study subjects. All the patients underwent enhanced CT scanning, and their CT manifestations and pathological features were analyzed. Results　A total of 76 lesions were found in the 54 patients, including unilateral single lesion in 36 cases, unilateral double lesions in 12 cases, bilateral single lesion in 5 cases(10 lesions), and bilateral multiple lesions in 1 case(6 lesions). The edges were clear in 63 lesions and fuzzy in 13 lesions. There were 74 lesions with cystic changes, 52 lesions in the superficial lobe, 14 in the deep lobe and 10 in the trans lobe. There were 60 lesions with upper-lower diameter being greater than anteroposterior diameter and left to right diameter. All of the 76 lesions were significantly enhanced in arterial phase, and the degree of enhancement in venous phase decreased. Fifty lesions showed “marginal vascular sign” after enhancement, and the vessels mainly came from the branches of posterior auricular artery and superficial temporal artery. Conclusion　CT findings in patients with parotid adenolymphoma are mostly circularly shaped with uniform density and clear boundaries, accompanied by cystic changes with intact capsule. Enhanced scanning shows significant enhancement in arterial phase and decreased enhancement in venous phase. The lesions mainly grow along the longitudinal axis, and Warthin tumor could be considered as a possibility in combination with “marginal vascular sign”.]]> 2020/6/1 16:44:46 CHEN Jin, LI Hui, LI Wei, et al. 20true ［Abstract］　Objective　To explore the therapeutic effect of kyphoplasty with unilateral puncture cement anchoring on Kummell′s disease. Methods　Seventy-four patients with Kummell′s disease received kyphoplasty with unilateral puncture cement anchoring in our hospital from May 2016 to December 2017, and the clinical effect was observed and evaluated. Results　The operations were successfully completed on the 74 patients, with a success rate being 100%. The average operation time was (52.38±5.12)min, and the average amount of bone cement injection was (5.97±0.51)ml. The Visual Analogue Scale(VAS) score, the Oswestry disability index(ODI) and the Cobb′s angle of the injured vertebra every time point after the operation were significantly lower than those before the operation(P<0.05). The height of the injured vertebra every time point after the operation was significantly higher than that before the operation(P<0.05). No loose or displaced bone cement was found during a 1-year follow-up. Conclusion　Kyphoplasty with unilateral puncture cement anchoring has significant curative effect, few complications and high safety in treatment of Kummell′s disease.]]> 2020/6/1 16:44:46 ZHANG Zai-qing, CHEN Bo 19true ［Abstract］　Objective　To explore the effect of pre-inserted slidable knot on wound healing after removal of drainage tube. Methods　A retrospective analysis was performed on 78 cases receiving various kinds of operations with drainage tubes in our hospital from January 2019 to November 2019. During the operations, the drainage tubes were sutured in advance to put the sliding suture knots. After the operations, the drainage tubes were pulled out to push the sliding suture knots to close the wounds. The suture knots were removed 5～7 days after pulling out of the tubes to evaluate the wounds healing. Results　Among the 78 cases, 72 cases(92.3%) had grade A healing; 3 cases(3.8%) had grade B healing; 1 case(1.3%) had grade C healing. The sliding suture knots could not slide on a pair after extubation in 2 cases with acute appendictis. 65 cases were followed up for 3～10 months, with a follow-up rate of 85.5%. Among them, 64 cases had neat wound margin and no infections, and the healing wounds presented linear scars, and the wound discomfort was slight; one case presented hypertrophic scar, which was considered as constitutional cause. Conclusion　Pre-suture and placement of slidable suture knots during surgery can promote the primary wound healing after extubation, which is a practical technique and worth promoting.]]> 2020/4/30 17:42:57 ZHANG Wan-yu, CHEN Jun-xing, TANG Shi-long 18true ［Abstract］　Objective　To observe the curative effect of patella claw combined with mesh suture using high-strength sutures on comminuted inferior patella pole fracture. Methods　A total of 42 patients with comminuted inferior patella pole fractures admitted to our hospital from January 2017 to August 2018 were selected. The patellar tendon and the bones of the inferior patella pole were sutured using high-strength sutures, and the fracture pieces were gathered together to rebuild the firmness of the inferior patella pole. Pressure fixation of the fractures was conducted using patella claw, and flexion-extension activity of knee joint and Bstman scoring system were used to evaluate the postoperative function. Results　All the patients were followed up for 12 months. The joint mobility of all the patients reached more than 120° three months after operation. The patella function score was excellent in 34 cases, good in 8 cases, and poor in 0 case. The excellent and good rate was 100%. Conclusion　Combination of patella claw and mesh suture using high-strength sutures is effective in treatment of comminuted inferior patella pole fracture and is worthy of clinical application.]]> 2020/4/30 17:42:57 ZHOU Hua-qiao, CHEN Jin-yue, YU Feng 17true ［Abstract］　Objective　To observe the clinical efficacy of day-time laparoscopic appendectomy based on enhanced recovery after surgery(ERAS). Methods　Ninety patients with acute appendicitis who underwent day-time laparoscopic appendectomy in our hospital from February 2018 to October 2019 were selected and divided into observation group and control group according to the random number table method, with 45 cases in each group. The observation group received perioperative treatment based on ERAS, and the control group received routine perioperative treatment. The first leaving bed time after operation, the postoperative exhausting time, the length of hospital stay, the degree of pain 6 hours after operation, the incidence of postoperative complications and the levels of plasma C-reactive protein(CRP) before and 1 day after operation were compared between the two groups. Results　The postoperative pain scores of the observation group were lower than those of the control group. The first leaving bed time after operation, the postoperative exhausting time, the length of hospital stay in the observation group were significantly shorter than those in the control group(P<0.05). The incidence of postoperative complications in the observation group(2.22%) was significantly lower than that in the control group(17.78%)(P<0.05). There was no significant difference in the level of plasma CRP between the two groups before operation(P>0.05). Compared with those before operation, the levels of plasma CRP in the two groups were significantly higher 1 day after operation, but the level of plasma CRP in the observation group was significantly lower than that in the control group(P<0.05). Conclusion　The day-time laparoscopic appendectomy based on ERAS can reduce surgical trauma, inflammatory response and complications, relieve postoperative pain, and shorten the postoperative recovery time, which is worthy of clinical promotion.]]> 2020/4/30 17:42:57 LIU Ru-feng, XU Jing-cong, HE Feng-lian 16true ［Abstract］　Objective　To estimate the stability of regenerated plaques after carotid stent implantation by contrast-enhanced ultrasound. Methods　Forty patients with regenerated plaques after carotid stent implantation in our hospital from January 2016 to August 2019 were selected as the research subjects. 65 regenerative plaques were detected by two-dimensional ultrasonography, and they were divided into soft plaque group(n=29), hard plaque group(n=21) and mixed plaque group(n=15) according to the two-dimensional ultrasound features of carotid atherosclerotic plaques. The development of plaques(contrast-enhanced ultrasound) was observed and the results were analyzed quantitatively. Results　The classification of neovascularization in the soft plaque group was significantly higher than that in the hard plaque group and the mixed plaque group(P<0.05). There was no significant difference in the classification of neovascularization between the hard plaque group and the mixed plaque group(P>0.05). The enhancement rate in the soft plaque group was significantly higher than that in the hard plaque group and the mixed plaque group, and the enhancement rate of the mixed plaque group was significantly higher than that of the hard plaque group(P<0.05). The peak strength, the peak time and the average transit time in the soft plaque group were significantly lower than those in the hard plaque group and the mixed plaque group(P<0.05). There were no significant differences in the peak strength, the peak time and the average transit time between the hard plaque group and the mixed plaque group(P>0.05). Conclusion　Contrast-enhanced ultrasound can show the neovascularization of carotid plaques, and evaluate the stability of regenerated plaques after carotid stent implantation, which is of great significance and practical value to prevent cerebral thrombosis.]]> 2020/4/10 18:04:33 LI Mao-yi 15true ［Abstract］　Objective　To observe the efficacy of Narrow-band ultraviolet B(NB-UVB) phototherapy combined with mucopolysaccharide polysulfate cream on chronic eczema in elderly patients. Methods　Eighty-five elderly patients with chronic eczema were randomly divided into treatment group and control group. The treatment group(n=48) was treated with NB-UVB phototherapy combined with mucopolysaccharide polysulfate cream. The control group(n=37) was treated with mucopolysaccharide polysulfate cream alone. The therapeutic effects of the two groups were determined after 8 and 12 weeks of treatment. Results　Forty-four cases in the treatment group and 36 cases in the control group actually completed the whole course of treatment. After 8 and 12 weeks of treatment, the effective rate of the treatment group was 61.36% and 86.37%, respectively, and that of the control group was 47.22% and 55.55%, respectively. The difference in the effective rate was statistically significant between the treatment group and the control group after 12 weeks of treatment(P<0.01). Conclusion　NB-UVB phototherapy combined with mucopolysaccharide polysulfate cream has good clinical effect on chronic eczema in elderly patients, with less adverse reactions and low recurrence rate.]]> 2020/4/10 18:04:33 SHAO Cheng-ming, CHEN Ting-ting, YAN Ting, et al. 14true ［Abstract］　Objective　To observe the effects of portable wrist joint continuous passive motion(CPM) device on upper limb function and quality of life in patients with upper limb fractures. Methods　Ninety-six patients with upper limb fractures were selected in our hospital from April 2017 to May 2018, and were randomly divided into observation group(n=48) and control group(n=48) by random number table method. The control group received routine nursing and functional exercise, and the observation group received the same treatment as the control group plus the intervention of portable wrist joint CPM device. The intervention effect was compared between the two groups. Results　There were no significant differences in the range of motion(ROM) scores of abduction, flexion, metacarpal flexion and dorsiflexion between the two groups before intervention(P>0.05). The ROM scores of abduction, flexion, metacarpal flexion and dorsiflexion in the observation group were significantly higher than those in the control group after intervention(P<0.05). The scores of physiological function, mental health, social function and body pain in the observation group were significantly higher than those in the control group after intervention(P<0.05). Conclusion　The application of portable wrist joint CPM device can promote the recovery of upper limb function and improve the quality of life in the patients with upper limb fractures after operation, which is worthy of application and promotion.]]> 2020/3/16 15:42:28 ZHU Xiao-long, WANG Yu-long, CHEN Wen-sheng 13true ［Abstract］　Objective　To observe the curative effect of minimally invasive surgery on moderate amount of hypertensive intracerebral hemorrhage and its effect on serum inflammatory factors. Methods　A total of 56 patients with moderate amount of hypertensive intracerebral hemorrhage who were admitted to our hospital from January 2016 to January 2018 were enrolled in this study, and were divided into control group and observation group according to the different operation methods, with 28 cases in each group. The observation group underwent minimally invasive puncture and drainage, and the control group underwent small bone window craniotomy. The clinical efficacy was compared between the two groups. Results　The hospital stay in the observation group was significantly shorter than that in the control group(P<0.05), and the hospitalization costs in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in hematoma clearance rate between the two groups(P>0.05). The levels of inflammatory factors［tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and high-sensitivity C-reactive protein(hs-CRP)］ were decreased in the two groups 7 days after operation, and the inflammatory factors in the observation group were significantly lower than those in the control group(P<0.05). The scores of Chinese Stroke Scale(CSS) and Activity of Daily Living(ADL) Scale in the two groups 6 months after operation were significantly lower than those before operation, and the scores in the observation group were significantly lower than that in the control group(P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group(10.71% vs 35.71%, P<0.05). Conclusion　Minimally invasive surgery has a good effect of clearing hematoma on moderate amount of hypertensive intracerebral hemorrhage, which can reduce the inflammatory response, improve the degree of neurological deficits and daily living ability. The operation is safe and reliable and has few complications.]]> 2020/3/16 15:42:28 CHENG Shou-yu, WANG Yan-dong, ZHANG Ji-quan 12true ［Abstract］　Objective　To explore the clinical efficacy of budesonide combined with curosurf in treatment of bronchopulmonary dysplasia(BPD) in premature infants. Methods　From January 2016 to December 2018, 123 premature infants with birth weight≤1 500 g or gestational age≤32 weeks who were complicated with respiratory distress syndrome(RDS) and needed respiratory support were randomly divided into observation group(n=61) and control group(n=62). The observation group was treated with budesonide combined with curosurf, and the control group was treated with curosurf. The changes in arterial blood gas analysis［pH, arterial partial pressure of carbon dioxide(PaCO₂), arterial partial pressure of oxygen(PaO₂)］, oxygenation index(OI), duration of mechanical ventilation, duration of oxygen supplementation, incidence of BPD, and incidence of other complications were compared between the two groups before and after treatment. Results　There were no significant differences in the indexes of blood gas analysis between the two groups before medication(P>0.05). The levels of pH, PaO₂ and OI of the two groups at 2 and 48 hours after medication were significantly higher than those before medication, while the level of PaCO₂ was significantly lower than that before medication(P<0.05). The levels of pH, PaO₂ and OI of the observation group were significantly higher than those of the control group 2 hours after medication and on the 7th day after medication, and in the 2nd and 3rd weeks after medication, and the level of PaCO₂ of the observation group was significantly lower than that of the control group. The levels of PaO₂ and OI of the observation group were significantly higher than those of the control group in the 4th week(P<0.05). Compared with the control group, the observation group had shorter duration of mechanical ventilation and shorter duration of oxygen supplementation, and lower incidence of BPD, and the differences were statistically significant(P<0.05). There were no significant differences in the incidence rates of the other complications between the two groups(P>0.05). Conclusion　Compared with curosurf alone, budesonide combined with curosurf can effectively improve the lung function, alleviate inflammatory injury of the lungs, prevent and treat BPD, but does not increase the incidence of complications.]]> 2020/2/18 17:19:02 CAI Lin, LI Xiao-dong, ZHANG Sheng-rong, et al. 11true ［Abstract］　Objective　To observe the efficacy of hot-wet compress combined with sacrum 2～sacrum 4 interval lumbosacral massage in promoting self-urination for women with urinary retention after natural delivery. Methods　From January 2017 to December 2018, one hundred and two cases of parturient women who could not urinate by themselves 6 hours after natural delivery were randomly divided into observation group and control group, with 51 cases in each group.The control group was given the treatment of hearing the sound of running water and glycerine enema, and the observation group received hot-wet compress combined with sacrum 2～sacrum 4 interval lumbosacral massage.The clinical effects of the two groups were observed and recorded. Results　The success rate of urination after delivery in the observation group was significantly higher than that in the control group(P<0.01). The rate of postpartum micturition delay and the rate of catheterization in the observation group were significantly lower than those in the control group(P<0.01). Conclusion　Massage of the lumbosacral region in the sacrum 2～sacrum 4 combined with hot-wet compress can induce self-urination for women with urinary retention after natural delivery. The method is simple, convenient and remarkably effective.]]> 2020/2/18 17:19:02 ZHANG Dong-mei, LIN Hong 10true ［Abstract］　Objective　To compare the efficacy and safety of insulin detemir and insulin aspart 30 in initial treatment of type 2 diabetes mellitus in elderly patients with mild cognitive impairment and their effects on cognitive function. Methods　One hundred elderly patients with type 2 diabetes mellitus and mild cognitive impairment were randomly divided into insulin detemir group and insulin aspart 30 group by random number table method, with 50 cases in each group. The insulin detemir group continued to take oral hypoglycemic drugs plus injection of insulin detemir at bedtime. The oral hypoglycemic drugs were discontinued and subcutaneous injection of insulin aspart 30 was given to the insulin aspart 30 group before breakfast and dinner. After 24 weeks of treatment, the changes in the levels of fasting blood-glucose(FPG), 2-hour postprandial blood-glucose(2hPG), glycosylated hemoglobin(HbA1c), total cholesterol(TC), triacylglycerol(TG), low density lipoprotein(LDL-C), blood pressure, body weight, body mass index(BMI), and Montreal Cognitive Assessment(MoCA) Scale scores were observed, and the blood glucose reaching target level, hypoglycemia and the occurrence of dementia were recorded. Results　After treatment, the levels of FPG, 2hPG,HbA1c and LDL-C were significantly lower than those before treatment in the two groups(P<0.05), and 2hPG, HbA1c in the insulin detemir group were better than those in the insulin aspart 30 group(P<0.05). There were no significant differences in the changes of TC, TG, blood pressure, body weight and BMI before and after treatment in the two groups(P>0.05). The rate of blood glucose control in the insulin detemir group was higher than that in the insulin aspart 30 group(P<0.05). Hypoglycemia occurred less and slightly in the two groups after treatment, and there was no significant difference in the incidence of adverse reations between the two group(P>0.05). There were no significant differences in MoCA scores between the two groups before and after treatment(P>0.05). Conclusion　Both insulin detemir and insulin aspart 30 are safe and effective in the initial treatment of elderly patients with type 2 diabetes mellitus and mild cognitive impairment. They can be used as the first choice for the initial treatment of insulin.]]> 2020/2/18 17:19:02 HE Xiang-cheng, WEN Zhi-gang, LI Yan-jun, et al. 9true ［Abstract］　Objective　To observe the effect of external diaphragm pacemaker(EDP) combined with swallowing function training on improvement of dysphagia after stroke. Methods　Eighty patients with dysphagia after stroke in the Third Affiliated Hospital of Sun Yat-sen University, Yuedong Hospital from April 2017 to May 2020 were divided into the observation group and the control group by random number table method, with 40 cases in each group, among whom 4 cases dropped out, and 76 cases were finally included for the statistics, including 39 cases in the control group and 37 cases in the observation group. The control group was given basic training of swallowing function, and the observation group was treated with EDP on the basis of basic training of swallowing function. The patients in both groups were evaluated for the swallowing function and the quality of life by Standardized Swallowing Assessment(SSA) and Chinese Swallowing Quality of Life Questionnaire(SWAL-QOL) before and 4 weeks after treatment.The incidence of pneumonia during the observation period was compared between the two groups. Results　After 4 weeks of treatment, the SSA scores of the patients in both groups were significantly lower than those before treatment(P<0.01), while the SWAL-QOL scores were significantly higher than those before treatment(P<0.01), and the observation group was better than the control group(P<0.05). The incidence of pneumonia in the observation group(8.1%) was significantly lower than that in the control group(33.3%)(P<0.05). Conclusion　EDP combined with swallowing function basic training can significantly improve the swallowing function of stroke patients, reduce the incidence of pneumonia, improve the quality of life, and the effect of the combined treatment is better than that of the simple swallowing function basic training, and the combined treatment is worthy of clinical promotion.]]> 2020/12/31 15:05:24 ZHANG Meng-fei, YE Peng-ying, PENG Zhi-yong, et al. 8true ［Abstract］　Objective　To explore the imaging features of different degrees of epidural lipomatosis in L₅/S₁ segment. Methods　The magnetic resonance imaging(MRI) data of 75 patients with different degrees of epidural lipomatosis in L₅/S₁ segment were collected, and the location and morphological characteristics of lipomatosis as well as the location and compression characteristics of the blind end of dural sac were analyzed. Results　The imaging features of different degrees of epidural lipomatosis in L₅/S₁ segment in all the cases were in damask ribbons, among whom, the focus of 72 cases was located in the ventral side of dural sac and the focus of 3 cases in the dorsal side. There were 21 mild cases, including only 2 cases(9.5%) of dural sac compression, 1 case of rectangle and 1 case of irregularity, and the blind end was randomly located on S₁ plane. There were 31 moderate cases, including 14 cases(45.2%) of dural sac compression, 8 cases of irregularity, 4 cases of “Y” shape, 2 cases of triangle, and the blind tubes of 24 cases(77.4%) were located in the middle of S₁ to the lower edge of L₅. There were 23 severe cases, whose dural sacs were obviously compressed(100.0%), showing “Y” shape in 9 cases, irregular shape in 7 cases, star shape in 3 cases, dot-line shape in 3 cases, triangle in 1 case, and the blind end of 19 cases(82.6%) was approximately flat to the lower edge of L₅. Conclusion　Different degrees of epidural lipomatosis in L₅/S₁ segment show certain characteristics in MRI findings, and the higher the grade, the higher the proportion of dural sac compression. Understanding these signs is helpful to prompting clinical attention.]]> 2020/12/31 15:05:24 HUANG Ce, ZHANG Feng-yi, XIA Zhen-yuan, et al. 7true ［Abstract］　Objective　To compare the efficacy and safety of super-mini percutaneous nephrolithotomy and retrograde intrarenal surgery in treatment of 1-2 cm single renal calculi. Methods　One hundred and ten patients with 1-2 cm single renal calculi were selected from Jiangmen Central Hospital during January 2018 and December 2019, and their data were retrospectively analyzed. The patients were divided into the observation group(super-mini percutaneous nephrolithotomy group, n=54) and the control group(retrograde intrarenal surgery group, n=56) according to different surgical methods. The operative time, intraoperative blood loss, postoperative hospital stay, stone-free rates 2 days and one month after operation, body temperature 24 hours after operation, white blood cell count(WBC), procalcitonin(PCT) and other inflammatory indexes as well as the incidence of systemic inflammatory response were compared between the two groups. Results　The operative time and the postoperative abnormal rate of PCT in the observation group were significantly lower than those in the control group(P<0.05), while the decrease of postoperative hemoglobin, and the stone-free rates 2 days and one month after operation in the observation group were significantly higher than those in the control group(P<0.05). There were no differences in the postoperative hospital stay, fever, abnormal rate of white blood cells and the incidence of systemic inflammatory response between the two groups(P>0.05). Conclusion　Both super-mini percutaneous nephrolithotomy and retrograde intrarenal surgery are safe and effective methods for treatment of 1-2 cm single renal calculi. Super-mini percutaneous nephrolithotomy has a higher stone-free rate and a lower risk of infection, while retrograde intrarenal surgery has less intraoperative blood loss and trauma.]]> 2020/12/5 15:52:01 ZHU Rui-long, CAI Chao, WU Rong-hai, et al. 6true ［Abstract］　Objective　To explore the clinical characteristics and prognosis of pediatric patients with 2019 corona virus disease(COVID-19). Methods　The clinical data of 11 children with COVID-19 and admitted to the People′s Hospital of Guangxi Zhuang Autonomous Region during January 19, 2020 and March 11, 2020 were retrospectively analyzed. Results　A total of 4 asymptomatic and 7 mild pediatric patients were included, all of whom appeared clustering occurrence. The typical CT images of the lungs was ground-glass opacity, which was completely absorbed after treatment. Five pediatric patients under 3 years old were found to be continuously positive for stool virus nucleic acid, lasting for 41 days at most. The levels of serum creatine kinase isoenzyme in 4 cases were more than 2 times higher than the normal value. The viral nucleic acid in the breast milk of the COVID-19 mother was negative. Conclusion　The clinical manifestations of the pediatric patients with COVID-19 are mild. However, more attention should be paid to the possibilities of ongoing myocardial damage and fecal-oral transmission in the children under 3 years old.]]> 2020/12/5 15:52:01 DAI Yan, TANG Ning-ning, XU Fan, et al. 5true ［Abstract］　Objective　To analyze the clinical characteristics and related risk factors of Parkinson′s disease(PD) patients complicated with depression and its influence on quality of life. Methods　From October 2017 to November 2018, the clinical data of 98 patients with PD diagnosed and treated in the Outpatient Department and Inpatient Ward of the People′s Hospital of Guangxi Zhuang Autonomous Region were collected. Hamilton Depression Rating Scale 17(HAMD-17) was employed to assess the depression of the patients. The patients were divided into groups according to whether they had depression or not and intergroup analysis was performed. Logistic regression analysis was carried out on the years of education, course of the disease, Hoehn-Yahr(H-Y) grade, Activities of Daily Living(ADL) Scale scores, Unified Parkinson′s Disease Rating Scale Part Ⅲ(UPDRS-Ⅲ) scores, daily dose of levodopa, the proportion of monoamine oxidase B(MAO-B) used and dyskinesia of the patients with PD. Results　Of the 98 PD patients, 41 cases had depression, and the incidence of depression was 41.84%. The depression group had significantly longer PD duration, higher H-Y grade and UPDRS-Ⅲ scores, and higher daily dose of levodopa than the non-depression group(P<0.05). The incidence of dyskinesia, and the proportion of MAO-B used in the depression group were significantly higher than those in the non-depression group(P<0.05). The years of education and ADL scores in the depression group were significantly less than those in the non-depression group(P<0.05). There were no statistically significant differences between the two groups in average age, age of onset, gender, Mini-mental State Examination(MMSE) score, smoking, drinking, constipation and incidence of anosmia(P>0.05). The results of Logistic regression analysis showed that H-Y grade(OR=7.959), high UPDRS-Ⅲ score(OR=1.480) and having dyskinesia(OR=1.417) were the risk factors of PD patients complicated with depression(P<0.05). The quality of life of the patients with PD complicated with depression was significantly impaired compared with that of the PD patients without depression(P<0.05). Conclusion　Depression is very common in PD patients, and the occurrence of depression is likely to be related to H-Y grade, high UPDRS-Ⅲ score and dyskinesia, which has a serious impact on the quality of life of PD patients.]]> 2020/12/5 15:52:01 LIU Bo, MO Ying-min, WEI Chun-ying, et al. 4true ［Abstract］　Objective　To investigate the value of echocardiography combined with high-sensitivity cardiac troponin I(hs-cTnI) and N-terminal pro-brain natriuretic peptide(NT-proBNP) detections in evaluation of cardiac function and early prediction of prognosis in neonates with sepsis. Methods　Eighty-five cases of neonatal sepsis hospitalized in the Neonatal Intensive Care Unit of Dezhou People′s Hospital from December 2016 to December 2019 were selected. They were divided into cardiac dysfunction group(41 cases) and normal cardiac function group(44 cases) according to whether cardiac systolic function was dysfunctional or not during hospitalization. The cardiac dysfunction group was divided into death group(15 cases) and survival group(26 cases) according to whether they were alive or not within 28 days after admission. The levels of peripheral blood hs-cTnI, NT-proBNP, echocardiographic indexes induding cardiac output(CO), and ratio of early diastolic peak(E) to late diastolic peak(A)(E/A) were observed in each group within 24 hours after the patients were admitted to the hospital and were diagnosed with sepsis, and the value of each index in judging cardiac function and predicting prognosis of the sepsis neonates were evaluated. Results　The levels of hs-cTnI and NT-proBNP in the cardiac dysfunction group were significantly higher than those in the normal cardiac function group, while the levels of CO and E/A in the cardiac dysfunction group were significantly lower than those in the normal cardiac function group(P<0.05). The levels of hs-cTnI and NT-proBNP in the death group were significantly higher than those in the survival group, and the levels of CO and E/A in the death group were significantly lower than those in the survival group(P<0.05). The levels of serum hs-cTnI and NT-proBNP were negatively correlated with CO and E/A of echocardiography in the sepsis neonates(P<0.05). Receiver operating characteristics(ROC) curve analysis showed that the area under curves(AUCs) of hs-cTnI, NT-proBNP, CO, E/A and the combination of the four indexes in evaluating the prognosis of the sepsis neonates were 0.854, 0.827, 0.769,0.738 and 0.902, respectively, which had high predictive value. The sensitivity and specificity of the combined detection of the four indexes were better than those of the single detection. Conclusion　Echocardiographic indexes combined with detections of hs-cTnI and NT-proBNP are helpful for early and comprehensive evaluation of cardiac function in sepsis neonates, and can be used to evaluate their prognoses, which has certain clinical significance.]]> 2020/11/3 8:38:30 YANG Ning, MA Jin-xia, LIU Shu-yuan 3true ［Abstract］　Objective　To compare the clinical effects of laparoscopic cholecystectomy(LC)+laparoscopic common bile duct exploration(LCBDE) and endoscopic retrograde cholangiopancreatography(ERCP)+endoscopic sphincterotomy(EST)+LC in treatment of cholecystolithiasis complicated with choledocholithiasis. Methods　One hundred patients with cholecystolithiasis complicated with choledocholithiasis were randomly divided into the observation group(n=52)(receiving LC+LCBDE) and the control group(n=48)(receiving ERCP+EST for 1～3 days, and then receiving ERCP+EST+LC). The clinical indicators were compared between the two groups. Results　The costs of hospitalization in the observation group were less than those in the control group, and the operation time and hospitalization days in the observation group were shorter than those in the control group, and the differences were statistically significant between the two groups(P<0.05). There were no significant differences in the success rate of gallstone removal, the incidence of complications and the recurrence rate between the two groups(P>0.05). Conclusion　LC+LCBDE is as safe and effective as ERCP+EST+LC in the treatment of cholecystolithiasis complicated with choledocholithiasis, but LC+LCBDE has shorter hospitalization time and lower hospitalization costs, which can be used as an effective remedial operation after EST fails in the treatment.]]> 2020/11/3 8:38:30 YAO Zhi-xun, PENG Qi-quan, YAO Shao-lin 2true ［Abstract］　Objective　To explore the application value, existing problems and quality control methods of cell block pathologic technique in cytological diagnosis of malignant serous cavity effusions(SCE) to further improve the accuracy of cell block pathologic diagnosis. Methods　Two hundred and seventy-six cases of malignant SCE were selected in our hospital during February 2016 and February 2018 for the operation process of conventional smear(CS) and routine cell block(RCB) technology before quality control. For the suspicious or negative cases by the diagnosis of RCB slice, quality control in cell block technology(QCCB) was performed again for pathology slice examination according to the preset 5 main quality control indexes. The results of the three diagnosis methods were compared and analyzed, and the accuracy of the three methods was compared, and their existing problems were analyzed. Results　Among the 276 cases of malignant SCE, 218 cases(78.99%) were diagnosed with malignant tumors by using CS method, in which 199 cases(72.10%) were diagnosed with definite tumors(clear classification), while 233 cases(84.42%) were diagnosed with malignant tumors by using RCB method, in which 225 cases(81.52%) were diagnosed with definite tumors(clear classification). By using QCCB method, 272 cases(98.55%) were diagnosed with malignant tumors, in which 270 cases(97.83%) were diagnosed with definite tumors(clear classification), and no misdiagnosis or missed diagnosis occurred. Compared with CS, RCB can improve the diagnosis rate of malignant tumors by 5.43% and the accuracy rate of classification diagnosis by 9.42%, but there were no significant differences between the two methods(P>0.05). Compared with CS and RCB, QCCB had significant differences in improving the accuracy of diagnosing and classifying the malignant tumors(P<0.05). Conclusion　Cell block technology is significantly superior to conventional smear in cytological and pathological diagnosis of malignant SCE. Strengthening the quality control of cell block technology in all linkages is helpful to reduce uncertain diagnosis and avoid misdiagnosis and missed diagnosis.]]> 2020/11/3 8:38:30 LI Yin, GAO Li, HE Hai-sheng 1true