［Abstract］　The application in angio-imaging diagnostic technique of carotid artery stenosis had made great progress, This article reviews the advances in the accuracy rating and superiority of the various kinds of non-invade angio-imaging diagnostic technique.]]> 2018/12/13 9:30:20 ZHONG Wei-zhang 905true ［Abstract］　Some coronary artery diseases, such as coronary artery spasm, myocardial bridges，microvascular angina, etc, can not diagnose definitely with coronary arteriography. Data shows that 10%～30% of patients which were finally diagnosed with coronary artery disease had normal coronary arteriography. Recent years with the rapid development of new techniques, such as intravascular unltrasound（IVUS) etc, we have new progress of coronary artery disease with normal coronary arteriography. This article discusses this problem and summarizes some coronary artery diseases with normal coronary arteriography, we hope to provide some assistance in making correct diagnosis and treatment of these diseases.]]> 2018/12/13 9:30:20 ZHANG Jun-feng, CAI Jiu-ying 904true ［Abstract］　The article reviews and summarizes the advance of laparoscopic hepatectomy on the feasibility，indications，the apparatus for hepatectomy，the technique of operation，complications and prevention.]]> 2018/12/13 9:30:20 XI Zhao-hua 903true ［Abstract］　CD4+ T cell is developed into two subgroups: Th1 and Th2. T helper 17, a new-type CD4+ T cell subgroup, was found in 2006. It mainly produces interleukin-17. The function of T helper 17 is opposite to that of CD4+CD25+T cell in inflamation. This paper supplies a summary on its differentiation and regulation as well as its relation with inflammation.]]> 2018/11/7 8:23:05 QU Shen-hong, LIANG Jian-ping 902true ［Abstract］　The case fatality rate of heart failure is above the average.The application of integrated traditional chinese and western medicine in the treatment of congestive heart failure has mad considerable headway, manifests the distinct dominances in the enhancement of curative effects, the improvement of symptoms, the raise of survival quality, and the avoidance of adverse effects ect, and its availability is confirmed by generally clinical practices.]]> 2018/11/7 8:23:05 TANG Jian-hong, LIU Chuan-yu, SU Han 901true ［Abstract］　Stroke is a common disease in clinic with which patients often remain some sequela.Traditional chinese medicine has its own unique advantages in the herbal treatment and rehabilitation of apoplectic sequelae.In order to investigate the progress on treating apoplectic sequela by TCM at present, the paper reviewed the current situation of chinese medicine rehabilitative approach to stroke residuals treated by applying chinese herbal medicine、acupuncture-moxibustion、manipulation and the chinese medicine composite method in the recent years.]]> 2018/11/7 8:23:05 HUANG Long-mo 900true ［Abstract］　In recent years, the health specialists of children, at home and abroad, have paid more attention to the impact, of the nutrition, especially the microelements on the development of the infant intelligence.They believe it is maybe because of the impact on the growth of nervous system. Now, this paper wll tell you two sides: one is the feature about the intellectual development of infant and the factors which infected it. The other is the relation between microelements and the intellectual development of infant.]]> 2018/11/7 8:23:05 ZENG Hui 899true ［Abstract］　Objective　To study the diagnosis and treatment of closed duodenal injury.Methods　The clinical data of 24 patient with closed duodenal injury who were treated in our hospital from May 1999 to May 2006 were retrospectively analyzed.Results　The clinical manifestation of closed duodenal injury was not specific, so its preoperative diagnosis rate was low.Majority of closed duodenal injury occurred in the duodenal descending part.The associated injuries were frequently found in the patients with closed duodenal injury.Among 24 patients with closed duodenal injury who were treated by operation, 22 patients were cured, 2 patients died.Conclusion　The key to the successful treatment lies in timely diagnosis and seletion of reasonable operative method.]]> 2018/12/3 8:39:12 LI Zhong-de 898true ［Abstract］　Objective　To evaluate the clinical efficacy of selective renal artery embolization for treating the kidney hemorrhagic diseases.Methods　Thirteen patients with kidney hemorrhagic diseases were treated by selective renal artery embolization.Before embolization, the selective angiography provided definite diagnosis on location, exent and degree of hemorrhage.Embolization materials used in the study were gelfoam and steel coils.Results　Embolization was successful and clinical symptoms subsided in all patients, no surgical complication had been observed.Conclusion　Selective renal artery embolization is safe and effective for the treatment of the kidney hemorrhagic diseases.]]> 2018/12/3 8:39:12 LI Rui-xiong, WANG Jun 897true ［Abstract］　Objective　To observe the compliance with oral iron supplementation in the patients with iron deficiency anemia.Methods　One hundred and twenty patients were randomly diveded into two groups.Sixty patients in the control group were routely given iron dextran and Vitamin C, sixty patients in the observation group were administrated xiaoyaowan, eight pills each time, and three times a day on the basis of treatment in the control group. Their side-effects were observed.Results　Compliance of the control group were 88.33%, that of the observation group were 98.33%.There were statistically significant differences between two groups (P<0.05).Conclusion　Compliance of the observation group was obvious higher than control group.]]> 2018/12/3 8:39:12 WANG Fu-zi 896true ［Abstract］　Objective　To study the changes of the human soluble vascuolar cell adhesion molecule 1 （sVCAM-1）and interleukin-6(IL-6) and their clinical significance in the children with viral myocarditis.Methods　Thirty-seven children who suffered viral myocarditis were chosen as the study group and twenty-eight health children received physical examination as the control group. The sVCAM-1 and IL-6 were detected in the blood samples taken from the children of both groups with the double antibody sandwich enzyme linked immunosorbent assay, and then the changes between the two groups were compared and their dependability were evaluated.Results　The concentration of sVCAM-1 in study group(1376.8±54.76 ng/ml) was significantly higher than that in the control group(714.85±276.54 ng/ml) (P<0.01). As for the IL-6, it is almost the same result. Furthermore the two indexes showed direct correlation, r=0.3210. Conclusion　The significantly higher concentration of sVCAM-1 and IL-6 in children with viral myocarditis play very important role in the pathogenesis of viral myocarditis.]]> 2018/12/3 8:39:12 MA Shao-chun, JIANG Yu-hong, A Shuang 895true ［Abstract］　Objective　To observe the effects of surgical treatment of femoral supracondylar comminuted fracture (FSCF).Methods　Open reduction surgery compression plate, cancellous bone screw fixation were used to treat 36 patients with FSCF, of them, three patients received bone grafting.Results　Bone healing occurred in 36 patients. follow-up period ranged from 2 to 6 years, with an average of 2.5 years. Slow infection of open wounds with osteomyelitis occurred in one patients, Four patients complicated by stiffness of knee joint were cured by the secondary operation. Plate removal time ranged from 12 to 26 months, with an average of 18 months.The effective value was performed in accordance with the knee function score hohl of therapeutic effect evaluation, including the degree of knee extension, activity, angles of internal and external turnover, walking distance and pain.Result showed excellent occurred in 18 patients (50%), good in 12 patients (33.33%), moderate in five patients(13.89%), poor in one patients (2.78%). Conclusion　Effects of the early surgical treatment for the femoral supracondylar comminuted fractures are excellent and can effectively prevent and cure the limb disability of the patients.]]> 2018/12/3 8:39:12 YOU Jian-ming, LUO Yu-chen, RAO Xing, et al. 894true ［Abstract］　Objective　To investigate the cosmetic effect of autogenous haire in the facial wound suture.Methods　One hundred and seventy-two patients whose facial region should be operated were divided into two groups according to the operative order number. The patients in the observation group were used autogenous hair to suture the skin layer of facial wound.while the patients in the control group were used 1～5 0 silk threads to suture the skin layger.Results　Compared with the control group, in the observation group the sewing thread response and sar formation were less after operation. There was significant defference between two groups（P<0.05）.Conclusion　Using autogenous hair in the facial wound suture can improve the quality of wound heading and cosmetic effect, and should be extended in clinic.]]> 2018/12/3 8:39:12 LI Tie-bin, LONG Shao-fen 893true ［Abstract］　Objective　To observe the changes of red blood cell parameters in patients with hepatic cirrhosis and study its clinical significance.Methods　Red blood cell count (RBC), hemoglobin (Hb), hematocrit(HCT), mean cell volume(MCV), red cell distribution width(RDW) of 45 patients with hepatic cirrhosis(the study group) and 42 healthy people (the control group) were examined and analyzed by test.Results　Compared with the control group, RBC, Hb and HCT of the study group descended evidently (P<0.05), and MCV, RDW increased significantly.With the increases of the Child-Pugh integrate, the abnormality of the red blood parameters aggravated gradually(P<0.05, P<0.01).Conclusion　There is abnormality of red blood cell parameters in patients with hepatic cirrhosis, some red blood cell parameters may reflect the pathogenetic condition and damage degree of liver disease.]]> 2018/12/3 8:39:12 LI Jie-lian, WU Jia-wen, LONG Jian-zhong 892true ［Abstract］　Objective　To summarize the occurrence of complications of cesarean section in our hospital in recent 6 years and explore the preventive measures of postoperative complications. Methods　The clinical data of short-term complications of cesarean section in cases of cesarean section were retrospectively analyzed. Results　In 1436 cases of cesarean section postpartum hemorrhage occurred in 73 cases(accounting for 5.08%), laceration of uterine incision in 28 cases(accounting for (1.49%); puerperal infection in 21 cases(accounting for 1.46%); abdominal distension in 10 cases(accounted for 0.69%); side injury in 1 ases(0.07%), all cases were successfully cured. Conclusion　Strictly grasping the indications for cesarean section, actively taking the according preventive measures before and during the surgery and the post-operative care and treatment, and improving the obstetric quality can reduce the occurrence of postoperative complications of cesarean section.]]> 2018/12/3 0:00:00 HUANG Zhen-yun 891true ［Abstract］　Objective　To discuss the methods of prerention and treatment of iatrogenic biliary tract injary.Methods　Eight cases of iatrogenic biliary tract injury due to cholecystectomy in our hospital during the past 15 years were retrospectively analyzed. the damage spot, type, discovery time, surgery method and treatment result were analyzed.Results　Six cases of biliary tract injury were found during the operation and were promptly treated by biliary tract end to end anastomosis, biliary intestinal anastomosis and biliary tract drainage;another 2 cases of biliary tract injury were found in 3 days after the operation and received reoperation.Conclusion　For iatrogenic biliary tract injury, the prevention is the key;the prompt discvery, and adoptipn of the effective surgery method in the operation is very important.]]> 2018/12/3 8:39:12 WANG Xiu-wen 890true ［Abstract］　Objective　China has seen the updated guidelines for community acquired pneumonia (CAP). It is the objective to evaluate the effect of educational intervention on CAP perception level of general practitioners.Methods　General practitioners were given a lecture on CAP as the educational intervention. Prior to and post-lecture, general practitioners were required to answer 10 questions included in a questionnaire about clinical findings, diagnosis and therapy of CAP based on the guidelines. Questionnaires were finished at present, independently.Results　Sixty and 56 general practitioners finished the questionnaires prior to and post-lecture, respectively. The percentage of correct answers to the questionnaires increased significantly post-lectures (72.1% vs 43.0%, P<0.01). The correct answers to 10 questions about CAP ranged from 16.7% to 65% and from 46.4% to 98.2%, prior to and post-lecture, respectively. Except for 2 questions, correct answers to the remaining 8 questions increased significantly post-lecture.Conclusion　The CAP perception level among general practitioners is not satisfactory and can be improved through the educational intervention.]]> 2018/12/3 8:39:12 HUANG Gui-xiang, QIN Zhi-qiang, LONG Sheng-ze, et al. 889true ［Abstract］　Objective　To explore the influence of psycholonical nursing care on the incidence of bladder spasm after transurethrol resection of prostate (TURP).Methods　One hundred inpatients with benign prostatic hypertrophy being ready for TURP were divided into intervention group (n=50) and control group (n=50) randomly. The patients were given routine nursing care in control group, the patients were given routine nursing and psycholonical nursing care in the intervention group before operation, during operation and after operation.Results　Compared with control group, the incidence and severity of bladder spasm after TURP in intervention group were significantly reduced (both, P<0.05).Conclusion　Psycholonical nursing care can reduce the incidence and severity of bladder spasm after TURP.]]> 2018/12/3 8:39:12 SU Yi-lai, HUANG Xing-min, YANG Zhen, et al. 888true ［Abstract］　Objective　To explore the reasons of discontinued therapy in drug taking patients with pulmonary tuberculosis.Methods　Fifty-one drug taking patients with pulmonary tuberculosis(observation group) in Guangzhou chest hospital were treated with the existing anti-tuberculosis treatment plan and holistic nursing in 2007～2008, and contrasted with patients with pulmonary tuberculosis who did not take drugs(control group). The statistics of drug taking patients with pulmonary tuberculosis who quitted the treatment were collected, and the reasons were explored.Results　After clinical treatment and nursing intervention, the number of patients who completed whole treatment or part stages treatment in observation group fewer than that of control group significantly（P<0.01）.Conclusion　Most of drug taking patients with pulmonary tuberculosis can′t complete the treatment and the reexamination, and the reasons are complex. It are associated with individual, the love of family and ethics, and also in relation to the cognition and manner of doctors, the department of the police and detoxification, human resources of hospital and so on.]]> 2018/12/3 8:39:12 WEI Yan-fang, TAO Shu, SHEN Hui-lan, et al. 887true ［Abstract］　Objective　To evaluate the nursing effects on the treatment of lumbar spondylolithesis by pedical screw spinal system.Methods　Forty-six cases of lumbar spondylolithesis had been treated by pedical screw spinal system in our hospital were reviewed and analyzed. The relation of nursing and clinical treatment result were observed.Results　All 46 cases were followed up for 4 months to 3 years and 6 months.There was a good clinical treatment result with a preoperative and postoperative nursing of high quality and no special complication.Conclusion　To finish seriously the perioperative nursing of science could increase the operative success rate and reduce the operative complication.]]> 2018/12/3 8:39:12 RAO Hai-fang, LI Hong-yu 886true ［Abstract］　Objective　To investigate the effective postoperative care of the old aged patients with acute pancreatitis and prevent the occurrence of serious complications.Methods　The main methods were giveing close postoperative oberservation to the 17 old aged patients with acute pancreatitis and strengthening the care of decompression, nutrition and drainage tube of stomach and intestines after operation.Results　Except one patient died of severe toxic shock, the remaining 16 patients recovered and discharged in stable condition.Conclusion　Closely observing the condition of the patients and giving special care to them can reduce the occurrence of postoperative complications and play an important role in the success of the operation.]]> 2018/12/3 8:39:12 LI Xia 885true ［Abstract］　Mage-A1 is a kind of tumor specific antigen. Many studies indicate that it can be a target antigen for tumor immunotherapy.This article summarizes the expression of Mage-A1 in tumors and its promising clinical practice in the tumor immunotherapy.]]> 2018/12/3 8:39:12 LI Xiao-lin, LIAO Hong 884true ［Abstract］　Cystatin C, a small molecular weight secreted protein, is a marker for evaluating glomerular filtration.In recent years, several studies suggest that cystatin C is a cysteine protease inhibitor and may be involved in the pathophysiological process of atherosclerosis and closely related coronary heart disease.]]> 2018/12/3 8:39:12 CHEN Xiang-gui, LIN Ying-zhong 883true ［Abstract］　There are many different views about the cause and pathogenesis of pterygium. The method of treatment of pterygium are multifunctional, the surgery is the main method. But it is difficult for recidivation. Now this review focused on the advancement of treatment of pterygium.]]> 2018/12/3 8:39:12 LI Shu-lin, WEI Li-jiao 882true ［Abstract］　Epilepsy is a common nervous system diseases and chronic diseases. 70%～80% of the epilepsy can be controlled with drugs. But within 5 years after drug control the recurrence in patients with epilepsy are more. In recent years, the research of relationship between epilepsy and magnesium ion show where has a certain relationship between magnesium ions and the pathogenesis of epilepsy, the magnesium ion has a protective effect on the brain, and magnesium sulfate adjuvant treatment of epilepsy can be effective in controlling seizures.]]> 2018/12/3 8:39:12 TANG Shi-qiang 881true ［Abstract］　It is reported that HIV/HCV co-infection is very common. The clearance of HCV would be hampered because of HIV-infection in human, resulting in the development of chronic hepatitis as well as liver cirrhosis. At the same time, HCV/HIV co-infection may accelerate the progress of HIV infection to AIDS. The treatment of HIV/HCV co-infection is still based on single infection, no co-treatment standard was provided.]]> 2018/12/3 8:39:44 WEI Jin -lu, XIE Zhi-chun 880true ［Abstract］　High free fatty acid can induce apoptosis of pancreatic islet β- cells, which is closely connected with the occurrence and the development of type 2 diabetes.The mechanism may be related to insulin receptor-substrate, key enzyme of the metebolism, oxidative stress, endoplasmic reticulum stress, Bcl-2 family，ceramide pathway，caspase family，12-lipoxygenase，PKB，G protein-coupled receptor, etc.The study on the effect of high free fatty acid on apoptosis of pancreatic islet β- cells has great clinical significance.]]> 2018/12/3 8:39:44 LIU Liang, LIU Li-bin 879true ［Abstract］　Wilms tumor(WT) is the most common malignent renal solid tumor in children. Dramatic improvements in survival have occurred as the result of advances in surgical management, irradiation and chemotherapy, however some cases are in poor prognisis and recidivation, metastasis and the fail of chemotherapy are the main cause. The tumor′s recidivation, metastasis and insensitivty to chemotherapy are correlated with vascularizative regulatoy and multidrug resistence.With the purpose of improving the therapeutic effect and survival, this article summarize current researches in WT and their mechanism of action.]]> 2018/12/6 8:49:55 DONG Chun-qiang 878true ［Abstract］　As the most common form in human genetic variance, human genome single nucleotide polymorphisms (SNPs) stand for genetic diversity of different race. The experts have made great advancement since detecting technology of SNPs develops rapidly. The article concisely reviews for detecting method of SNPs and its application in analyzing genetic diversity of different race.]]> 2018/12/12 16:20:04 JIAO Wei, LIU Fei. 877true ［Abstract］　The Human Genome Project (Human Genome Project, HGP) has successfully completed, which greatly stimulate the study of structure and function, positioning, cloning of the human disease-related genes.After the basic human genome draft had been drawn, the HGP also enter into the functional genomics era;the focus of life science resesrch has also escalated from the study of gene sequences into gene function studies.Therefore the advanced technology of Gene chip has developed gradually. Being different from those traditional methods, such as low time and money consuming, high performance and accuracy, which make gene chip fit to be used in clinic gene testing. In addition, its features of easy manipulation, standardization and popularization endue it perfect prospect in clinical application. The goal of this review is to outline the progress of gene chip teachnology and it′s application in the study of disease.]]> 2018/12/12 16:20:04 WANG Min, WANG Shao-yuan 876true ［Abstract］　Subacute thyroiditis(SAT) is the most familiar painful disease of the thyroid gland. It is treated easily but is diagnosed difficultly for its various clinical features, and the rate of misdiagnosis is often high. Each diagnostic method has its good and bad aspect respectively, the nuclear medicine is now the most common means for the diagnosis of SAT in clinical practice, since its simple, non-invasive and high accuracy. Up to now, there is not a standard diagnostic method. Accurate diagnosis rate could be improved by clinical course combined with some methods.]]> 2018/12/12 16:20:04 WEI Zhi-xiao, QIN Wei-wu 875true ［Abstract］　 Ischemic renal disease (IRD）ultimately culminate in end-stage renal disease(ESRD）, and is usually the result of renal artery stenosis（RAS）, cholesterol embolism or renal artery thrombosis. Renal tubule impairment is the most common in the pathologic changes of IRD. Clinical feature indicative of IRD is the progressing renal insufficiency, and renal artery stenosis with renal insufficiency can strongly suggest IRD. The gold standard for diagnosis of ischemic renal disease is renal angiography. Interventions, surgery and medications can be beneficial.]]> 2018/12/12 16:20:04 WU Qiu-xia, GONG Zhi-feng, ZENG Xi. 874true ［Abstract］　Magnetic resonance angiography（ MRA）, as one of the latest technologies in angiography，due to its non-invasive, non-ionizing, less time-consuming and low cost，has been widely used in clinical examination in recent years, and it keeps on technically reforming. This artical mainly describes the mechanism of Magnetic resonance angiography, its benefits, and its limitation, especially about the latest development of MRA in detail.]]> 2018/12/12 16:20:04 Zhao Cheng-jin, LUO Shu-guang 873true ［Abstract］　 The ¹³¹I therapy for hyperthyroidism is the earlist and the most complete therapy in radioiodine therapy, it acts as a special and important role in the therapies for hyperthyroidism, and will play a more and more important role with its being reunderstood and its scope of treatment being widened.]]> 2018/12/12 16:20:31 XIONG Xing-hui, QIN Wei-wu 872true ［Abstract］　Objective　This paper has summed up the research development adiponectin in clinical-related diseases.Methods　The data of adiponectin were obtained by document retrieval and integrated.Results　Document retrieval has shown that adiponectin in clinical-related diseases has become a hot-topic in related study.Conclusion　Being a biological indicator, adiponectin has played an important role in clinical-related diseases.]]> 2018/12/12 16:20:31 ZHANG Yu-dou, LI Shao-hua 871true ［Abstract］　Rectocele is the major reason of female outlet obstruction constipation (OOC). Because of the poor effect of medicine, domestic anus and intestine doctors develop operations by recta, cunt and perineum etc. Meanwhile, operations obtain satisfactory effects. Operation fashion is emphasized and summarized in this article. Furthermore, it helps the scholars to master the operation technology which is based on the experience of predecessor so that improves the cure rate and reduces complications and recurrence rate.]]> 2018/12/12 16:20:31 ZENG Juan-ni, TANG Qian-li 870true ［Abstract］　With the development of radiation therapy, clinical physicians pay more and more attention to the precise outline of nasopharyngeal carcinoma radiotherapy target. Therefore the position of imaging diagnosis is indispensable in diagnosis and treatment of nasopharyngeal carcinoma. Especially, CT, MRI, PET aplication developed extraordinary important function in the establishment of clinical stages of nasopharyngeal carcinoma and protocols for treatment and the evaluation therapeutic effect and prognosis.]]> 2018/12/12 16:20:31 WU Ning-bo, CHEN Yun-bin 869true ［Abstract］　Objective　To study the diagnostic and treatment methods of early colorectal neoplasm and to evaluate the value of these methods.Methods　Authors reviewed the recent thesis of early colorectal cancer, studied the diagnosis and treatment methods, introduced new methods including endoscopic mucosa resection(EMR)　Results　The treatment methods include endoscopic polypectomy or endoscopic mucosa resection(EMR)、transanal local excision for early rectal cancer.Conclusion　Endoscopic polypectomy or endoscopic mucosa resection(EMR)　and transanal local excision for early rectal cancer are useful for diagnosis and treatment of early colorectal cancer, and correct preoperative staging of colorectal neoplasms is of significance in guiding treatment.]]> 2018/12/12 16:20:31 LU Zhi-mei, CHENG Ji-gui, ZHANG Yu-xing 868true ［Abstract］　Hysteromyoma is common ailments and frequently-occurring diseases.This review describes minimally invasive surgery in treatment of hysteromyoma, such as the laparoscopics urgeryforldilmyoma, the embolization therapy of hysteromyoma, radiofrequency ablation, high intensity focused ultrasound technique, targeted cryoablation therapy, microwave and PEI.]]> 2018/12/12 16:20:31 MA He-qun, JI Liu-yu 867true ［Abstract］　Anesthesia machine is used frequently in clinical anesthesia, but now there haven′t reference standards in the evaluation of the performance of this machine. This article reviews the appraisal of the effectiveness and security of anesthesia machine in order to build a system to judge the performance of anesthesia machine.]]> 2018/12/12 16:20:31 HUANG Ai-lan, QIN Ling 866true ［Abstract］　von Willebrand factor has a great significance in the progress of hemostasis and thrombokinesis，the deficiency of von Willebrand factor will result in von Willebrand disease，and its activity will obviously increase in the patients with thrombotic thrombocytopenic purpura, coronary heart disease, the infiltration and diversion of tumor, diabetic nephropathy.The review articles will discuss the research progress of von Willebrand factor and above-mentioned diseases relation.]]> 2018/12/13 9:29:22 HU Hong-zhang, LIN Fa-quan 865true ［Abstract］　 E-cadherin is a class of calcium-dependent membrane glycoprotein that mediated the intercellular adhesion of epithelial cells. It is combinated with catenin family members of the α-catenin, β-catenin, γ-catenin and p120ctn, and constitute a combination of cadherin catenin complex(CCC), which maintain the intercellular adhesion of epithelial cells, normal epithelial tissue structure and integrity of the polarity and play an important role in the evolution of the tumor. E-cadherin/p120ctn abnormally expresses in malignant tumors, might be play a certain role in the development, invasion and metastasis of malignant tumors.]]> 2018/12/13 9:29:22 OU Hai-ling, QIN Yu-zhou, ZHANG Xi-liu 864true ［Abstract］　 Parkin gene, identified as a causative gene of Parkinson′s disease(PD), has been studied more and more on the construction, function and transcription, expression. Especially, Epigenetics is raised as the important clue，to comprehend PD for us from another view. This article summarizes Parkin gene，in detail on the construction, function and transcription, expression, as well as tries to state its methylation possibility.]]> 2018/12/13 9:29:22 YANG Hua-dan, LUO Shu-guang 863true ［Abstract］　 Rhinosinusal inverted papilloma is a benign lesion. It accounts for 0.15 percent to 4 percent of nasal tumour, but with aggressive, high recurrence rate（6% to 48%）, easy to malignant change（7% to 27%）, and the transfer and the multi-center clinical features. These have aroused people′s attention in recent years. At present its pathogenesis and mechanism of malignant change are not clear. Researches on malignant change-related factors of Nasal inverted papilloma have been reviewed in recent years in this paper.]]> 2018/12/13 9:29:22 WANG Huan, YU Hong 862true ［Abstract］　 The utilization of the precision attachment is more and more extensive, and the useing of the ball attachment is wide-ranging in the clinical prosthesis because of its biology mechanics superiority, such as a extracoronal precision attachments, the ball attachment might pave new way for the clinical prosthesis of dental defeats.]]> 2018/12/13 9:29:22 ZHONG Ai-xi 861true ［Abstract］　Protein Z is a vitamin K-dependent protein, a cofactor for dependent protease inhibitors (ZPI), can inhibit factor Ⅺa in the presence of phospholipid and calcium ions; ZPI can inhibit protein Z and Ⅺa，There are preliminary studies on the relationship between ZPI with thrombotic disease.]]> 2018/12/13 9:29:51 HUANG Chun-yu, WANG Le-min 860true ［Abstract］　Mediterranean anemia which is a hereditary disease leads damage not only to the blood system, but also to the heart.At present, the integrated and foreign-assisted treatment are major metheds besides gene therapy and stem cell transplantation.The spleen is one of the main places where abnormal red blood cells are destructed, so the splenectomy could reduce symptoms of anemia and alleviate the condition. But as an immune organ, it is reported that splenectomy would lead a variety of infectious diseases, especially in children. This article will give a summary to the recent literatures of the past one or two decades that how the humoral and cell-mediated immunity function change and what is the relationship between the function change and ages for the Mediterranean anemia post-splenectomy children.]]> 2018/12/13 9:29:51 WANG Hui-zhen, TANG Xian-ming 859true ［Abstract］　The detection of survival myocardium has become to hot spot with the widespread application of coronary artery revascularization recently. Ischemic parafunctional segment in coronary heart disease patient maybe is really inconvertible myocardial damage, or recoverable damage. The former usually make of necrosis myocardium and scar tissue, the latter include hibernating myocardium、stunning myocardium and maimed myocardium. The amplitude and severity extent of myocardial reversible defect is one of important predict factors to detect major heart incidents in coronary heart disease patient. How to identify these survival myocardium within coronary heart disease patient especially myocardial infarction patient, and therefore perform coronary artery revascularizartion earlier, will improve left ventricle entirety contractile function and prognosis. It is important to judge segment wall motion abnormalities whether has survival myocardium or not. It has considerable significance to choose further therapeutic regimen、predict curative effect and judge prognosis.]]> 2018/12/13 9:29:51 ZHENG Ping, CAO Li 858true ［Abstract］　The expanded blood volume in advanced cirrhosis contributes to a persistent increase in cardiac output, which may overload the heart.In other circumstances, increased cardiac output and augmented cardiac work would cause cardiac failure.But, because of the decreased afterload, as reflected by reduced systemic vascular resistance and increased arterial compliance, left ventricular failure may be latent in cirrhosis.Cardiac failure may become manifest under strain or treatment with vasoconstrictors. This type of cardiac dysfunction has been termed “cirrhotic cardiomyopathy”(CCM).This article reviews current status and research development in the pathogenesis, pathology, diagnosis and therapy of cirrhotic cardiomyopathy.]]> 2018/12/13 9:29:51 CHEN Feng-song, ZHAO Jian-mei 857true ［Abstract］　The human Rh blood group system is one of the most clinically significant red blood cell system next to ABO, and as well the most complicated and polymorphic in blood group systems. Modern molecular biology studies have shown that Rh antigens are encoded by RHD and RHCE. Gene RHD is coding Rh D polypeptide, RHCE coding RHC/c and RHE/e, respectively. Incompatibilities of antigen-antibody in the Rh blood group system can cause hemolytic transfusion reactions, hemolytic disease of the newborn and autoimmune hemolytic anemia.]]> 2018/12/13 9:29:51 SHEN Wei-dong, TANG Qiu-min 856true ［Abstract］　Diffuse axonal injury, with difficulties in diagnose and treatment, is a common problem in clinical work, and the prognosis is poor. Diffusion tensor imaging is a new technology that can describe quantificationally changes of integrity, histopathology and function. It has more and more remarkable significance in the diagnosis, the observation of therapeutic effects and the evaluation of prognosis of diffuse axonal injury.]]> 2018/10/22 8:14:38 MA Chun-lin, ZHENG Wen-bin 855true ［Abstract］　Sudden deafness is a common disease of otology, but the etiological factor and pathogenesis are not clear. The blood supply of labyrinthus oticus and brain stem source from vertebral-basal artery system. Most scholars consider that the disorder of microcirculation in cochlea is one of the important reasons. Transcranial Doppler ultrasonography (TCD) is a detection technique using physics and electrophysiology technology, which has the characteristic such as no pain and wounds, simple and easy maniputation, better reproducibility. Detecting the changes of haemodynamics in arteria basilaris by TCD can more exactly judge the extent and scope of the cerebral ischemia, observe the relation between the morbility of sudden deafness and the changes of haemodynamics in vertebral-basal artery and posterior inferior cerebellar artery, understand the information of blood flow in single blood vessel, directly observe the spasm or contraction of vertebral-basal artery, the extent and scope of the cerebral ischemia. The value of research is important in studying the pathogenesis and improving the detection rate of sudden deafness.]]> 2018/10/22 8:14:38 TANG De-ping, ZHU Qiu-mei 854true ［Abstract］　Constant progress of endovascular repair in abdominal aortic aneurysm is made in recent years, In particular, endovascular repair of renal abdominal aortic aneurysm already has the same value with open surgical repair, which is now reviewed.]]> 2018/10/22 8:14:38 YUAN Jun, LIN Yin-zhong 853true ［Abstract］　The application of perceptual learning in neurological basis, diagnostic technique and treatment of amblyopia had made great progress. This article reviews the advances in this new conception of amblyopia.]]> 2018/10/22 8:15:02 LIN En-wei, LIU Wei-min 852true ［Abstract］　Endothelin-1（ET-1）, one of the endothelin family, is the most powerful endogenous vasoconstrictor and predominant isoform in the cardiovascular and renal systems. ET contributes to endothelial dysfunction and atherosclerosis, so it lends to cardiovascular accident. On the other hand，ET stimulates renal cells proliferation, inflammation and extracellular matrix synthesis. Through those, ET promotes renal fibrosis. Antagonist of ET system may not only reduce cardiovascular risk，but also may be of benefit in improving renal function and reducing proteinuria， which provide a new way for renal disease treatment and prevention.]]> 2018/10/22 8:15:02 GONG Zhi-feng, YE Kun 851true ［Abstract］　As an important part that incorporated in the microinvasive neurosurgery, endoscopic neurosurgery has gained great progress in resent 10 years, which manifested itself in two ways: its extending application and indication. This is a comprehensive review of the developing history, surgical indication and complications of endoscopic neurosurgery.]]> 2018/10/22 8:15:02 TANG Shu-hong, TAN Hai-tao 850true ［Abstract］　Tibial Pilon fracture is always a challenge to orthopedic surgeons. Careful assessment of the injury, especially the soft tissue condition, is essential for a proper treatment planning. Classification of the fracture is also important for evaluation of the prognosis. Treatment planning includes: timing of the surgery, selection of the fixation method and postoperative treatment. The curative effects are relative to Pilon fracture type, replacement quality and operation time of tibial Pilon fracture. Proper selection of the surgical procedure plays an important role in the treatment and prognosis for patients with Pilon fracture.]]> 2018/10/22 8:15:02 LI Zhi-guang 849true ［Abstract］　Acute coronary syndrome(ACS) is one of the primary causes of the mortality and morbidity in coronary heart disease. Recently, along with the progress of pharmacotherapy and widely application of primary percutanous coronary intervention in the treatment of coronary heart disease, the treatment effectiveness and the progress of ACS were improved significantly.This article reviews the advances in the treatment of ACS.]]> 2018/10/22 8:15:02 HU Chang-xing, XU Guang-ma 848true ［Abstract］　In our country, with the increasingly high requirements of controlling costs, optimizing the allocation of resources, the ambulatory surgery is in a period of rapid growth. This paper introduces progress of ambulatory anesthesia from the definition of outpatient anesthesia, preparation of anesthesia, drug selection, managements of postanesthesia, discharge standards and the risks and complications of anesthesia.]]> 2018/10/22 8:15:02 GONG Xiao-fang, CHEN Jian-hua 847true ［Abstract］　Portal vein tumor thrombus is an important bionomics for hepatocellular carcinoma, and also is an important factor which influences the prognosis of hepatocellular carcinoma. In this paper, we will review the formation, typing and surgery of hepatocellular carcinoma with portal vein tumor thrombus.]]> 2018/11/7 8:22:37 WU Dong-bo, HUANG Shun-rong, WU Hong-gen 846true ［Abstract］　Acute kidney injury (AKI) is a common clinical problem defined by an abrupt (within 48 hours) increase in serum creatinine resulting from an injury or insult that causes a functional or structural change in the kidney. Serum creatinine and urine output are common measures reflecting renal function. Currently, there is a lack of sensitive and specific markers for kidney injury available in clinical practice although several kidney-specific biomarkers are under development. Despite substantial technical improvements in treatments, mortality and morbidity associated with acute renal failure remain high.]]> 2018/11/7 8:22:37 TANG Ge, PENG Xiao-mei 845true ［Abstract］　Psoriasis vulgaris is an intractable dermatosis with chronic inflammation.Because of the rapid development in biology and combined research of Chinese and western medicines, there have been lots of new medicine and new technologies and methods, which causes the progress of the treament of refractory vulgaris. This essay aims at summarizing the progress of clinical treatment.]]> 2018/11/7 8:22:37 ZHANG Jian-ling 844true ［Abstract］　Traditionally the most widely used biomarkers for the early detection of acute kidney injury are proteinuria, serum creatinine, and blood urea nitrogen. All of these are less optimal and tend to focus attention on later stages of injury when therapies may be less effective. Recently, there has been a great surge of interest in identifying novel biomarkers that can be easily detected in the urine and can diagnose renal injury at the earliest stages. A variety of methods have been employed to identify these biomarkers, including proteomics, metabolomics, and gene arrays. Currently, several candidate biomarkers have been identified and studied. These include kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin (IL)-18, Sodium Hydrogen exchanger isoform 3 (NHE3) and fatty-acid binding proteins (FABPs). This review will highlight the current state of knowledge of these biomarkers as well as the limitation of these biomarkers in the early diagnosis of renal injury.]]> 2018/9/10 8:34:49 ZHANG Wen-xin,GONG Zhi-feng 843true ［Abstract］　Leptin is encoded by obese gene, and it is a kind of peptide hormone mainly synthesized and secreted by fat cells. By binding its receptors, it plays the role of inhibiting diet, reducing energy intake, increasing energy expenditure, and so on. Cardiac hypertrophy refers to the myocardial cell volume increases and diameter widening or length increase and the growing number of sarcomere。At present, mechanism of cardiac hypertrophy has not been completely clarified.A variety of mechanical stimulation, chemical factors, may be the major mechanism.In recent years, the relationship between leptin and cardiovascular disease has aroused widespread concern, in addition to anti-obesity and maintenace of energy balance, leptin have a close relationship with myocardial hypertrophy.It may play an important role as an endogenous substance in cardiac hypertrophy.This paper reviews the relationship between leptin and cardiac hypertrophy.]]> 2018/9/10 8:34:49 WANG Xiao-shan,XU Tong-tong 842true ［Abstract］　Gynecologic chronic pelvic pain(CPP)is the clinical manifestations in many kinds of diseases. Its cause is complex, and the pathogenesis completely is not yet clear. It is mainly treated by symptomatic treatment. This article carries on the summary of its cause and treatment.]]> 2018/9/10 8:34:49 LIANG Xue-fei 841true ［Abstract］　Diffuse axonal injury(DAI)is a series pathological changes,which are characterized by nervous axon break in brain,caused by special force. The conscious disturbance is the typical clinical manifestation. This paper summarizes the recent progress of DAI in the diagnosis and treatment.]]> 2018/9/10 8:34:49 LIANG Zi-cong,XIAO Quan 840true ［Abstract］　Many clinical informations show that it is reasonable to interfere hypertensive cerebral hemorrhage by early operation,as it can decrease the mortality of cerebral hemorrhage, and improve pronosis for the patients obviously. This article reviews some related documents from 1995 to 2007,and introduces the indication, times, types,and result of operation for hypertensive cerebral hemorrhage and so on,which provide the experience for its clinical treatment.]]> 2018/9/10 8:34:49 WEI Zu-bin,XIAO Quan 839true ［Abstract］　A accurate and reliable detection method is the key to diagnosing gastric H pylori infection and valuing clinical therapeutic effect. According to the different ways of drawing materials H pylori detections can be divided into invasive and non-invasive methods, the former include microbiological method, morphologic examination,urease-dependent tests； the latter include serological, genetic molecular biology detection, feces H pylori antigen detection，and so on.]]> 2018/9/10 8:34:49 HUANG Pei-ning 838true ［Abstract］　The melanoma antigen(MAGE)was expressed in a variety of malignant tumors,mainly in melanoma,therefor,detection of MAGE genes and proteins in different histological types of malignant tumors is a prerequisite for clinical tumor immunotherapy.In this paper, the detection methods and significance of level of MAGE gene and protein are reviewed.]]> 2018/9/10 8:35:16 YANG Jing, LIAO Hong 837true ［Abstract］　Postoperative scarring is the main reason for the failure of glaucoma filtration surgery.Many researchists have been searching new surgery treatment and technique recently.Different treatments are reviewed in this article.]]> 2018/9/10 8:35:16 YANG Ke, DU Ning-jing 836true ［Abstract］　Breathing filter(BF) also is known as bio-filter, heat and moisture exchange filter, artificial nose, etc. BF is used in breathing circuit in mechanical ventilation with different levels of biological filtration function and the role of heat insulation and moisture.in recent years BF has been gradually used in clinic as a protection of the airway during mechanical ventilation to lower respiratory circuit microbial contamination, as well as used in the clinical detection such as pulmonary function test ect. as one of the measures of control hospital infection to prevent cross-infection.]]> 2018/9/10 8:35:16 ZHAI Li-li,LI Yong-lu 835true ［Abstract］　Gestational diabetes mellitus (GDM), one of high risk pregnancy, is relate to insulin resistance (IR) and function defect of beta cell of islet. At present, insulin therapy is the best choice for the control of glycometabolism disorder of GDM. In recent years, various nursing interventions for pregnant women with diabetse are developed in perinatology, which have positive significance in controling blood glucose and reducing mother- infant complications. Here is a review about study progress in nursing interventions.]]> 2018/9/10 8:35:16 LIU Wei-zhen,MA Gang 834true ［Abstract］　With the progress of science, the diagnosis of syphilis, espeially the laboratory diagnosis, and treatment have be developed, the paper reviews the recent development of diagnosis and treatment of syphilis.]]> 2018/9/10 8:35:16 ZHOU Min-ling 833true ［Abstract］　Now the effect of exposure time of sperm-oocyte coincubation on fertilization, embryonic development quality and pregnancy outcome in vitro fertilization(IVF) has been given more and more attention. Adequate shortened exposure of oocytes to spermatozoa improves in-vitro fertilization outcome ：high quality embryo rates and pregnancy rates is increased, delightful clinic outcome is obtained.]]> 2018/9/17 8:12:27 HUANG Li, XUE Lin-tao, HE Bing 832true ［Abstract］　Carpal tunnel syndrome is the most common entrapment peripheral neuropathy in clinical, in which the median nerve is compressed at the wrist, leading to paresthesia and functional disorder.The electroneuromyography is helpful in qualitative and anatomical diagnosis of the entrapment syndrome,and has great value in the early diagnosis and treatment of carpal tunnel syndrome.]]> 2018/9/17 8:12:27 ZHANG Li-xiang,LI Lv-li 831true ［Abstract］　Acute coronary syndrome(ACS) is one of main cause of the mortality and morbidity in coronary heart disease.Recently, with the progress of pharmacotherapy and widely application of primary percutanous coronary intervention in the treatment of coronary heart disese,the treatment effectiveness and prognosis of ACS have been improved significantly.This article reviews the new research progress of ACS.]]> 2018/9/17 8:12:27 LI Xing-yang,RAO Shao-lai 830true ［Abstract］　With today′s continuous improvement of quality of life,obesity gradual increase, most of which is simple obesity due to excess nutrients. The obesity can lead to cardio-cerebral vascular diseases, as well as diabetes, hyperlipidemia and other diseases, therefore, the topic of weight loss become fashionable. The acupuncture and massage in the treatment of simple obesty has made good clinical efficacy, in the mechanism resenrch, acupuncture is ahead of massage,and the effect mechanism has been stndied on the central nervous system, the autonomic nervous system, the endocrine regulation of metabolism, the weight loss based on receptor theory, the massage is not enough for research depth in these areas. In this paper, the review on effect mechanism of acupuncture and massag in weight loss is performed.]]> 2018/9/17 8:12:27 GAO Xin,LV Ya-nan 829true ［Abstract］　Parkinson′s disease is one of the most common neurodegenerative disorders，the pathogenesis is still not well established. In recent years, many studies have suggested that mitochondrial DNA point mutation may play an important role in its pathogenesis, in addition, improvement of mitochondrial function may bring some new insights for the prevention and treatment of parkinson′s disease.]]> 2018/9/17 8:13:20 XIAO You-sheng, WANG Jin 828true ［Abstract］　The hepatolobectomy is an important method in treating liver occupying lesions. Because of the special structure of the liver anatomy, the petients often face the risk of bleeding in hepatolobectomy, and need to infuse a lot of red blood cells, plasma and so on.Which made patients to face the complications of massive transfusion. Therefore, using an integrated blood conservation measures has become a hot issue in the during of liver resection. This article summarized a variety of blood conservation measures in the clinical application of hepatolobectomy briefly.]]> 2018/9/17 8:13:20 ZHANG Guang-ying,LIN Cheng-xin 827true ［Abstract］　Intracranial aneurysms are the most common causes of non-traumatic subarachnoid hemorrhage (SAH). Mortality will increase if intracranial aneurysms rupture again, so early diagnosis is very important for clinician. More and more intracranial aneurysms were detected by computed tomography angiography (CTA) and digital subtraction angiography (DSA). As a noinvasive technique, CTA is important in diagnosing intracranial aneurysms. This article will review diagnosis value and research progress of the CTA imaging techniques.]]> 2018/9/17 8:13:20 WEN Hong-zhi, ZHENG Wen-bin 826true ［Abstract］　Regional chemotherapy is an important measure for the treatment of primary liver cancer，including hepatic arterial infusion, portal vein thrombosis, sustained-release preparations for tumor, etc. Regional chemotherapy may decrease recurrence rate after surgery and increase survival rates.]]> 2018/9/17 8:13:20 LI Pei, LIANG Zhong-xiao 825true ［Abstract］　The immune organs are important zones for immune cells to regenerate and differentiate. The normal structure of lymph nodes (LNs) as peripheral immune organs is crucial to keeping own inner environment balance and keeping the immune cells surviving, growing and regenerating. Recently, some foreign researchers find that the accumulation of collagen fibers in T cell zone (TZ) may be another important pathogenesis of decreasing CD4⁺ T cells in peripheral blood and lymph tissues in HIV infectors. This paper expounds the effect of normal LNs structure on CD4⁺ T cells′ surviving, growing and transporting, and explains the relationship between changed structure and pathogenesis of acquired immune deficiency syndrome(AIDS), so that it would be helpful in the study of present pathogenesis and clinical treatment of AIDS.]]> 2018/9/17 8:13:20 LU Xiang-chan,TAN Yi 824true ［Abstract］　The ubiquitin is named because it is widespread. The ubiquitin-dependented degeneration of protein influence the cellular biology,such as structure and function of chromosomes, reproduce and expression of genetic information, transduction and regulation of cellular information by degenerate the futile protein and inactive organelles.Transforming growth factor(TGF)-β and TGF-β/Smads signaling played a critical role in the tissue repair and organ fibrosis. The regulatory mechanism of TGF-β/Smads signaling is complex and especially with the termination of it by the ubiquitin-proteasome is intensively studied, a key enzyme-Smurfs which mediate the ubiquitin-dependented degeneration of Smads specifically was discovered and researched. This review focused on the latest studies on the Smurfs and the physiological and pathological significance in tissue repair and organ fibrosis.]]> 2018/9/28 10:50:38 PENG Peng,ZHANG Guo,ZHANG Fa-can. 823true ［Abstract］　Laryngeal mask is an air breather of upper glottis between endotracheal and mask ventilation. Because of easy operation and fewer complication impairing air tube, it is widely usedly in clinical and its insertion methods was continuously improved. This article is to summarize the clinical application of three blind visited insertion methods and the laryngeal mask′s postoperative complications.]]> 2018/9/28 10:50:38 LU Han-dong, LIN Chen-xin 822true ［Abstract］　Lumbar disc herniation is a self-existed disease since the advent of human. The medical profession constantly sums up the clinical and experimental experience,and has derived new techniques for the treatment of lumbar disc herniation to open up new avenues.To this end, the porfiles of the surgical treatment of lumbar disc herniation would be reviewed in this article.]]> 2018/9/28 10:50:38 QIAN Jun,LIN Jian 821true ［Abstract］　In this paper,the literatures related to the nurse professional value view at home and abroad in nearly 20 years were reviewed. From aspects of the meaning and content of nurse profession value view,the scholars′ understandings of nurse professional value view at home and abroad were explained.The evaluated method about practicing the nurse professional value view was concluded and the research progress on nurse professional value view at home and abroad was reported.]]> 2018/9/28 10:50:38 QIN Feng-qiong, WEI Qu 820true ［Abstract］　Gastrointestinal stromal tumors（GIST） as a kind of frequent enteron tumor which originate from lobus intermedius tissue have been taken into basic and clinical research for many years. With the continuous research people make a gradual realization of GIST primordially from tissue origin to nowadays gene level on basis of which Imatinib has been manufactured in the process of clinic work to cure GIST more sensitively than other chemotherapeutics. In such conditions the research concerning GIST has been made a excellent progression under the care of scientists. In this paper a summary of previous study of predecessor would be made to explain the molecule generating mechanism of GIST.]]> 2018/9/28 10:51:44 CHEN Ping, ZONG Liang 819true ［Abstract］　The atrial fibrillation(AF),whose prevalence rate in the population is growing, becomes popular disease in cardiovascular disease in the new century. Until now, in the effective treatment of AF,there are still many problems to be solved, particularly the problem about how to take measures to prevent its occurrence and maintain sinus rhythm after cardioversion in high-risk populations can be described as basically a blank.In recent years, many studies have found that angiotensin Ⅱ is closely related to the occurrence and maintenance of AF, angiotensin Ⅱreceptor antagonist(ARA) has the role of reducing AF.In this paper,from aspects of pathogenesis, clinical treatment and so on elaborates the role of ARA on the AF.]]> 2018/9/28 10:51:44 QI Chuan-xing, PANG Ming-mei 818true ［Abstract］　Amblyopia is an eye disease which shows clinically abnormality in best corrected visual acuity, and researches demonstrated many patterns of manifestation. This article reviewed the patterns of visual deficits in amblyopia and then investigated their clinical values.]]> 2018/9/28 10:51:44 ZHAO Wu-xiao, LIU Wei-min 817true ［Abstract］　Objective　To introduce the best ways of therapy for hypopharyngeal cancer.Methods　A synthesis analysis was performed on some results form many big hospital of the world.Results　 Laryngeal function- sparing surgery is better than non function-sparing surgery.Therapeutic effect can be improved through preoperative radiotherapy or postoperative radiotherapy.Conclusion　Selective laryngeal function- sparing surgery and preoperative radiotherapy or postoperative radiotherapy is recommended.]]> 2018/9/28 10:51:44 DENG Yu-yuan,YANG Rong-ning 816true ［Abstract］　With the improvement of living standard,children′s dentofacial deformities also are gradually increased, and the treatment of these diseases inreasingly arouse the orthodontic doctors to attention. The domestic status of this orthotherapy are reviewed.]]> 2018/9/28 10:51:44 WEI Jing 815true ［Abstract］　With the development of the laparoscopic technology, the application range of laparoscopic surgery in gynecology is also gradually expanded. In this paper, the recent situation of laparoscopic surgery in the treatment and diagnosis of gynecologic acute abdomen, endometriosis, benign and malignant tumor is briefly reviewed.]]> 2018/9/28 10:51:44 NONG Xiao-yan,TAN Yi 814true ［Abstract］　Baicalin(C₂₁H₁₈O₁₁) is a kind of falconoid compound, extracted from dried root of Labiatae skullcap (scutellaria baicalensis georgi). Baicalin is the main active ingredient and has a variety of pharmacological effects, such as heat-clearing and detoxifying, antibacterial and anti-inflammatory, antagonizing calcium, clearing free radicals, anti-endotoxin shock, regulating immunity, adjusting blood pressure, protecting liver and cholagogic effect, anti-allergy and anti-lipid peroxidation, and so on. In recent years, animal experiments and clinical studies have confirmed that baicalin has the effects of anti-fibrosis and organ protection.]]> 2018/10/8 8:27:44 ZHANG Ling-ling,GUO Ming-hao 813true ［Abstract］　COX is a rate-limiting enzyme in generation of prostaglandins. It is considered COX-2 is primarily releted to the generation of prostaglandins in the process of inflammation and positively releted with the occurrence the development of atherosclerosis. However, selective COX-2 inhibitors have increased the incidence of cardiovascular events. The reason for the imbalance between PGI₂ and TAX₂ doctrine has been widely accepted. In recent years, studies have shown that selective COX-2 inhibitors has many other new roles and side effects, there is a great need for doing a new judgement on the role of selective COX-2 inhibitors.]]> 2018/10/8 8:27:44 CHEN Li-feng,XU Tong-tong,ZHU Hua 812true ［Abstract］　Continuous positive airway pressure (CPAP) can maintain alveoli at a certain end-expiratory pressure, increasing functional residual capacity to prevent alveolar collapse in order to improve ventilation and ventilation functions. CPAP is mainly used for breathing difficulties, bad inflated lungs of newborn.The indications are mainly early or mild to moderate neonatal respiratory distress syndrome, apnea of prematurity, neonatal wet lung, excessive pulmonary edema after the withdrawal of mechanical ventilation and so on. Nasal CPAP as a method to avoid endotracheal intubation, reducing mechanical ventilation, is simple and suitable for neonatal respiratory support technology.]]> 2018/10/8 8:27:44 CHEN Qi-tang 811true ［Abstract］　Postoperative patients with differentiated thyroid carcinoma often need undergoing iodine-131 to further eliminate residual thyroid tissue and treat metastatic lesions that may exist to reduce the rate of recurrence and matastasis. Scintigraphy has a big appliation value in formulation of the next diagnosing and treating plan，judgment of prognosis and appraisal of curative effect and so on. This article carries on the summary on the application of radionuclide imaging after the operation of differentiated thyroid carcinoma.]]> 2018/10/8 8:28:25 WANG Xiao-gang,WEI Zhi-xiao 810true ［Abstract］　The thiazolidinediones(TZDs) are peroxisome proliferator-activated receptor (PPAR)-γ agonists. In addition to improving insulin sensitivity and glycemic control, TZDs also play critical roles in the vasculature by improving endothelial dysfunction, decreasing the expression of several inflammatory mediators, inhibiting the proliferation and migration of vascular smooth muscle cells and the development of restenosis after vascular interventions.]]> 2018/10/8 8:28:25 WU Xu-bin, WU Guang-wei, LIN Ying-zhong 809true ［Abstract］　The technique of hysteroscopy and laparoscopy in various gynecologic operations in our country have arrived the international advanced level.This paper makes a overview of the application and development of hysteroscopy and laparoscopy operation in gynecologic disease.]]> 2018/10/8 8:28:25 LIU Ni-ping, CHEN Chang-yi, MA Gang 808true ［Abstract］　Lipoxins are a class of eicosanoid that possesses a wide spectrum of antiinflammatory and proresolution bioactivities that include inhibition of leukocyte-mediated injury, stimulation of macrophage clearance of apoptotic neutrophils, repression of proinflammatory cytokine production, modulation of cytokine-stimulated metalloproteinase activity, and inhibition of cell proliferation and migration. These data suggest that lipoxins may be considered as promising therapeutic approaches to many inflammatory diseases.]]> 2018/10/8 8:28:53 MA Li,HUANG Zhong-hua,LIANG Ning 807true ［Abstract］　Chronic cervicitis is one of the most common genecological diseases, which can cause pelvic inflammatory diseases and has a close relationship with the incidence of cervical cancer. Its pathogenesis is diversified.The varied therapy are used to treat this dease,and the local treatment, for emample，the physical therapy, drug therapy and surgery, is the primary therapy so far.]]> 2018/10/8 8:28:53 LU Jin-ling,MA Gang 806true ［Abstract］　Early repolarization variant is a common electrocardiographic finding that is generally considered to be benign. A recent multicenter study has shown that early repolarization variant in the inferolateral leads is associated with idiopathic ventricular fibrillation and sudden cardiac death.]]> 2018/10/8 8:28:53 YANG Peng 805true ［Abstract］　As the technique and instrumentation of hip arthroscopy improves, this procedure will become increasingly commonplace in the use of hip arthroscopy to diagnose and treat intra-articular pathology of the hip joint. This article provides a comprehensive overview of hip arthroscopy over the past 15 years, including indications, contraindication, operating procedure and complications. Hip arthroscopy provide a good way of hip joints with minimally invasive, short rehabilitation and few reported complications and does not hinder opportunities for future surgical interventions. Hip arthroscopy will play an important role increasingly in hip joint surgery.]]> 2018/8/27 8:16:11 SUN Ke, YIN Dong 804true ［Abstract］　Cholestasis isn′t an independent disease, but a syndrome with chiefly manifestations such as jaundice, itch of skin, dysfunction of liver. Since the etiology is complex, the diagnosis and treatment should be based on reasonable examination.]]> 2018/8/27 8:16:11 WEI Xiao-dong, LI Jing, ZHANG Guo 803true ［Abstract］　Acute severe ischemic stroke is one of global disease with higher mortality and disability rates. In this paper clinic outcome, the therapeutic principles and the recent research progress on acute severe ischemic stroke should be described.]]> 2018/8/27 8:16:11 LUO Yong-jian, LI Lv-li 802true ［Abstract］　This paper introduced many kinds of treatments for moving molar distally by conventional or implant anchorage in malocclusion patients and their effects. It was concluded that intraosseous implant was one type of dependable anchorage and the appliance to move molar distally by it was simple and effective.]]> 2018/8/27 8:16:11 HUANG Min-fang 801true ［Abstract］　Metabnomics which is an important component of systemic biology is a newly developed subject which analyzes small-molecule metabolite profiles of a certain creature or cell qualitatively and quantitatively. In recent years, the application of metabnomics in medicine has gradually become more and more extensive with its rapid development. In this article, we try to summarize the application of metabnomics in various aspects of medical research in recent years.]]> 2018/8/27 8:24:30 YING Jian-min,DENG Xin,TAN Yi 800true ［Abstract］　Coronary angiography is the most valuable method in the diagnosis and treatment of coronary heart disease. For the special structure of the coronary artery anatomy and the diversity of coronary artery lesion, coronary angiography for the assessment for coronary artery disease has been insufficient to meet clinical needs, besides, with the development of coronary stent technology, the emergence of poor adherence of the stent and stent thrombosis increases, the patients will suffer from major cardiovascular events. Therefore, the application of intravascular ultrasound in coronary interventional procedures has become a hot spot. The intravascular ultrasound applied in coronary interventional procedures are reviewed in this article.]]> 2018/8/27 8:24:30 LIU Ling, LIN Ying-zhong 799true ［Abstract］　Papillary thyroid carcinoma is one of the highest incidence of thyroid cancer, however,its prognosis is better than other types. Currently,surgical treatment is the main treatment for thyroid cancer,because radiation and chemotherapy is absent sensitivity for papillary thyroid cancer and generally were unfavorably chosen.Gene therapy will become hot reseach and expect to break the cure of thyroid cancer.This article reviewed research progress on surgical treatment of papillary thyroid carcinoma.]]> 2018/8/27 8:24:30 WEI Xing-zhong, LIANG Zhong-xiao 798true ［Abstract］　Edaravone is a potent novel free radical scavenger. It has the effects of eliminating free radicals and inhibiting lipid peroxidation. In recent years, its scope of clinical application gradually expanded.In this article, its application profile in the treatment of nervous system diseases is briefly reviewed.]]> 2018/8/27 8:24:30 XU Yuan-sheng,TAN Yi 797true ［Abstract］　The top cause of maternal death in China is post-partum hemorrhage, among which uterine inertia accounted for 70%～80%. Once postpartum hemorrhage due to uterine inertia was found, uterotonics should be used as early as possible, intrauterine packing and uterine compression suture, uterial arterial ligation and selective artery embolization should be applied as ways to control the bleed and if all of these treatments failed, hysterectomy should be performed timely.]]> 2018/8/27 8:24:30 WEI Xian-qiong，MA Gang 796true ［Abstract］　Pressure sores are common in nursing of patients of long-term poor limbs, activities. In this paper, the epidemiology causes, the assessment prevention, treatment, and care of pressure sores are reviewed in order to prevent and reduce the incidence of pressure sores and improve the patients′ quality of life.]]> 2018/8/27 8:24:30 LIANG Miao-ling, CAI Bao-fang,YANG Xi-ning 795true ［Abstract］　Refractive status of infants is related to visual development of children.In domestic infant refraction examination the suresight vision screening instrument was usually used.The domestic literature on the accuracy of suresight vision screening instrument in refraction examination and its application status in refraction examination of infants in recen years were reviewed.]]> 2018/8/27 8:24:30 TANG Ye-wei，LIU Wei-min 794true ［Abstract］　Toll-like receptors (TLRs) play a pivotal role in innate and adaptive immune responses. They recognise pathogens through signaling pathways. Accumulating evidence suggests TLRs are important in autoimmune disorders(SLE,RA). A greater understanding of the processes by which TLRs regulate adaptive immunity may yield new approaches to the treatment and prevention of autoimmune disorders.]]> 2018/8/31 16:02:31 WU Jia-biao, REN Min 793true ［Abstract］　Palatal arch is widely adopted in orthodontic treatment. This paper describes the history, construction, mechanic principles and clinical utilization of palatal arch in order to provide a new idea for its reasonable application.]]> 2018/8/31 16:02:31 HE Jin-an 792true ［Abstract］　Every year, there are about 30 thousand babies born with Down syndrome(DS) in China, which ranks the third among all kinds of birth defects. In order to reduce the birth of babies with DS, the interventional prenatal diagnoses, such as chorionic villus sampling, amniocentesis and cordocentesis, have been widely carried out in recent years, which has reduced the birth of babies with DS.However, the risk of invasive operation and the long period of waiting will cause the heavy mental pressure of pregnant women. Therefore, the study on a series of new techniques has been developed, including preimplantation genetic diagnosis, isolation of fetal nucleated red blood cells from maternal peripheral blood, isolation of cell-free fetal DNA in maternal plasma, endocervical fetal trophoblast. The fetal cells or DNA samples have been successfully obtained with those non-invasive methods. Moreover, the techniques of molecular biology have brought new prospects to the rapid and accurate diagnosis of DS, including fluorescence quantitative polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), primed in situ labeling (PRINS) and array comparative genomic hybridization (Array-CGH). In this paper, we aim to make a summary on the progress of the basic research and clinical application of prenatal diagnosis for DS.]]> 2018/8/31 16:02:31 QIN Ting, SHI Yue-qiu 791true ［Abstract］　Impetigo herpetiformis is an acute and serious pustular disorder that occurs primarily in pregnancy. The onset commonly presents in the last trimester of pregnancy; the condition may persist until delivery and it rarely continues in the postpartum period. There is an increase in morbidity and mortality for the mother and the fetus. As a result, immediate diagnosis and treatment is crucial.]]> 2018/8/31 16:02:31 LI Yu-qiu 790true ［Abstract］　In the clinical application of orthodontic anchorage,malocclusion implant anchorage has achieved good control of anchorage,and has obtained satisfactory results in the treatment of difficult cases who had higher control requirement for control implant anchorage.Therefore,implant anchorage gradually has been recognized and accepted by orthodontic doctor.At present,the research of implant anchorage has become one of the hot area in orthodontic research.In this paper,research status of micro-screw implant anchorage was reviewed.]]> 2018/8/31 16:02:31 HE Ke-wei 789true ［Abstract］　The major technologies of syphillis laboratory test includes pathogen test；serological test,including antibody test of nonspecific reagin and specific antigen test and polymerase chain reaction,which can be applied in the diagnosis of syphillis in various periods.]]> 2018/8/31 16:02:31 LU Qiu-wei 788true ［Abstract］　Peroxisome proliferator-activated receptor-γ(PPAR-γ), a member of the superfamily of intranuclear receptor transcription factor that regulating the gene expression,involves in the regulation of metabolism, cellular proliferation,differentiation and apoptosis. Its crucial role in immune system determines the close association with the occurring and development of metabolic diseases and immunological diseases. Recently, further studies have demonstrated that PPAR-γ is critical in the pathogenesis of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer and pulmonary fibrosis et al. And PPAR-γ agonist might hopefully be a new therapy to chronic respiratory diseases.]]> 2018/7/16 16:35:43 WU Cong,LU Hua-song 787true ［Abstract］　Mild cognitive impairment (MCI) is a transition state between normal aging and dementia. It is a high-risk group of Alzheimer disease (AD), so the early diagnosis and early intervention is the key to prevention of dementia. In recent years, neural imaging and neural biology research of MCI have made good progress.]]> 2018/7/16 16:35:43 MO Ying-min, HAN Min 786true ［Abstract］　The adult avascular necrosis of femoral head（ANFH） is difficult to cure and seriously affects the daily life of patients. Clinical treatment has no significant effect in the past. With the development of technology, all kinds of new methods and techniques have significantly improved the clinical efficacy in the recent years. This is a review of methods and techniques for adult ANFH.]]> 2018/7/16 16:35:43 ZHANG Shen-qi, SHAO Lin 785true ［Abstract］　Hypertension cerebral hemorrhage is a common cerebrovascular disease and surgical treatment of the disease plays an important role. On the reference to medical literature at home and abroad in recent year, the surgical treatment methods of hypertension cerebral hemorrhage were introduced in this paper.]]> 2018/7/16 16:35:43 HUANG Xin-chao,TAN Yi 784true ［Abstract］　The carcinoma of gallbladder (CG) is the most common malignant tumor in bile duct, its pathogenesis is hide； malignant degree is high ； prognosis is disappointment. Survivin is a member of the inhitor of apoptosis protein family, it has specific biological behaviors which play a important role in apoptosis and proliferation of cell and exert regulation effect on cell cycle.The excessive expression of Survivin gene has close relationship with clinic significance and carcinogenesis of CG，its expression might become one of efficient target of judging the biological behavior and prognosis of CG. The article provides a brief review of clinic new recognition about characteristics of molecalar biology of Survivin including basic structure, distribution and anti-apoptosis function and clinic significance of its abundantly expressed in CG.]]> 2018/7/16 16:35:43 LUO Cheng-fu,TAN Yi 783true ［Abstract］　Rural health education, also known as health education in rural areas, is an important part of new rural development. It′s good for promotion of social progress. In this paper, we will explore the current status of education in rural health issues and strategies.]]> 2018/7/16 16:35:43 LONG Teng 782true ［Abstract］　Mitochondria plays a central role in energy production and fuel utilization. Disordered mitochondrial function can impact whole-body metabolic homeostasis. As a transcriptional coactivator, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is essential for the mitochondria energy metabolism. This review focuses on the role of PGC-1α in mitochondria energy metabolism and the effect on it after dealing with the PGC-1α transgenic mice of overexpression, null and knock-out.]]> 2018/7/16 16:36:20 Effect of PGC-1α on the mitochondria energy metabolism 781true ［Abstract］　Minimal invasive surgery and better cosmetic outcome are the developing trend in surgical area. Accordingly, transumbilical single-incision laparoscopic surgry is gaining great interest all over the world. Ongoing refinement of the surgical technique and instrumentation is likely to expand its role in gynaecologic surgery in the future.]]> 2018/7/16 16:36:20 Application of laparoscopic technique via transumbilical single-incision in gynaecologic surgery 780true ［Abstract］　The etiopathogenisis of premature ovarian failure(POF) is complicated, this illness can not be cured easily. Incidence of POF is ascending year by year. POF is one of the diseases which compromise women′s health and breeding competence severely. Hormone replacement therapy is traditional strategy to POF patients. For the past few years, some new methods have been used to heal POF patients, such as induced ovulation, assisted pregnancy technology, conserving ovarian function, ovarian allograft, immunotherapy and so on.]]> 2018/7/16 16:36:20 Advance of therapy in premature ovarian failure 779true ［Abstract］　Zona pellucida is an important structure closely related to oocyte maturation, normal fertility and embryo implantation. More studies show that the zona pellucida property had a close relationship with the subsequently developmental potential of embryo. In this paper, the studies about the relationship between zona pellucida and developmental potential of oocyte and embryo were reviewed.]]> 2018/7/16 16:37:43 CHENG Jun-ping, HUANG Li, HE Bing, et al. 778true ［Abstract］　Enterovirus 71 (EV71) infection can cause hand foot and mouth disease (HFMD).In the severe case HFMD can be complicated with cental nervous system damage, neurogenic pulmonary edema, neurogenic myocarditis and so on. This paper reviewed the pathogenesis, clinical manifestation, diagnosing and treating of HFMD complicated with central nervous system damage.]]> 2018/7/16 16:37:43 ZHANG Cai-ru, XIE Fu-jing, JIANG Jiu-xi 777true ［Abstract］　Ascites due to liver cirrhosis is one of the main complication in hepatocirrhosis decompensated phase,the formation of ascites due to liver cirrhosis not only affects the quality of life of patients,but also increases the risk of spontaneous pertonitis，renal failure and upper gastrointestinal bleeding, and is an index of ominous prognosis.In this paper, the research progress on the formative mechanism and the treatment of ascites due to liver cirrhosis in the recent years are reviewed.]]> 2018/7/16 16:37:43 BEI Guang-ming，LI Hai-qiang，WEI Gang 776true ［Abstract］　Clinical data have showed that the patients′ clinical symptoms will appear if skull defect is greater than 3 cm in diameter. The best time of repair is in 2 and 3 months after surgery, and there will be conductive to recovery of nervous function repair, and improve ment of clinical symptoms. The choice of cranial bones′ repair material is the key in the cranioplasty. And there is a direct relation between the biocompatibility and the improvement of patients′ cerebrovascular hemodynamics and nervous′ function. By reviewing some correlative documents from 1993 to 2010,this paper introduces the operation time of repair of skull and different repair material and its effect in order to offer the thought and reference for treatment skull defect.]]> 2018/7/16 16:37:43 WEI Zu-bin,TAN Yi 775true ［Abstract］　Catheter ablation for atrial fibrillation (AF) is rapidly becoming the most commonly performed catheter ablation procedure worldwide. In contrast to patients with PAF, PV isolation (PVI) alone is insufficient for the greater majority of patients with persistent AF. These patients, are in need of receiving multiple (more than two) catheter ablation procedures ( i.e. substrate ablation; complex fractionated atriaI electrograms ablation; linear lesions; AF-Nests ablation ) in order to achieve a higher success rate.]]> 2018/7/16 16:37:43 DENG Jin-long,WU Yin-xiong 774true ［Abstract］　Laparoscopic myomectomy is one of common surgical procedures in the treatment of symptomatic uterine myoma. It has the advantages of less trauma, less postoperative adhesions, quicker postoperative recovery, smaller scar and so on. In this paper,the progress of this technique in recent years is reviewed.]]> 2018/7/16 16:37:43 JIANG Li，MA Gang 773true ［Abstract］　Acinetobacter baumannii is an opportunistic pathogen with increasing relevance in a variety of nosocomial infections. To date, the organism shows a formidable capacity to develop multi-drug resistance, which has become a significant challenge to modern healthcare systems. In this article, we review the current control and treatment options for Acinetobacter baumannii infections.]]> 2018/7/16 16:37:43 CHEN Jie-yu,GONG Zhi-feng 772true ［Abstract］　Pneumocystis pneumonia (PCP) is a common kind of serious and sometimes fatal pneumonia in AIDS patients. Because of its clinical nonspecific manifestations it is easily misdiagnosed, its laboratory diagnosis is more important. This paper mainly introduces the laboratory diagnostic methods of PCP including routine examination sputum, BALF, lung tissue biopsy morphology diagnosis, molecular diagnosis, PC culture and immunology diagnosis, etc.]]> 2018/7/31 15:05:07 CHEN Jing-jie, HE Han,SU Ling-song,et al. 771true ［Abstract］　Systemic lupus erythematosus is autoimmune rheumatic disease, characterized by the damage of multisystems and organs，damage the kidney was called lupus nephritis.It affects predominantly young women.It was an important problem about pregnancy to the patients of systemic lupus erythematosus.Pregnancy would trigger an exacerbation of the disease.And the pregnancy outcomes would worse compared to healthy women.Once,pregnancy is contraindication for the patients of systemic lupus erythematosus.To date,Accumulating evidence indicated that the patients of systemic lupus erythematosus would give birth to a healthy child if they chose the right time for pregnancy and monitored the disease carefully.This review is about the pregnancy of the patients of systemic lupus erythematosus.]]> 2018/7/31 15:05:07 MO Min, LAI De-yuan 770true ［Abstract］　The latest research shows that ambroxol is a kind of new mucus solvent. In addition to its expectorant effects, there are a variety of pharmacological effects.This paper reviews the application of aerosol inhalation of ambroxol in prevention and treament of pulmonary complications of postoperative patients in recent years, focused on its mechanism, efficacy, timing of medicine, adverse reaction, incompatibility of drugs in a prescription, and so on.]]> 2018/7/31 15:05:07 LUO Yi-gen,TAN Yi 769true ［Abstract］　Barrett′s esophagus is associated with a high risk of esophageal adenocarcinoma.Besides conventional endoscopy and pathologic biopsy,some new endoscopic diagnosis technology were obtained in recent years. This article will review the recent advances in the diagnosis of Barrett′s esophagus.]]> 2018/7/31 15:05:07 LIAO Ri-bin，TANG Jian-guang，SHU Yan-bo， et al. 768true ［Abstract］　Diabetic dephropathy is a major chronic complication of diabetes and has become the leading cause of end-stage renal failure, primarily reflected by renal glomerular filtration rate (GFR). In recent years, clinical trials have shown that serum cystatin C (Cys C) has good correlation with GFR,and Cys C can be used as a surrogate marker for the diagnosis of diabetic nephropathy. Cys C is a low molecular weight protein, and is a member of relatively small molecular weight cysteine proteinase inhibitor superfamily. Cys C is produced by all nucleated cells of the body, in constant rate. Cys C in circulationcan freely pass through the glomerular filtration membrane, and in the proximal tubule is reabsorbed almost completely, not return to the blood circulation, while Cys C is not secreted by renal tubules. So it is an ideal endogenous marker in reflecting the changes of GFR. The constant development of methodology for Cys C determination also makes application and promotion of serum Cys C in determination the early diagnosis possible.]]> 2018/7/31 15:05:07 ZHAI Hong-yan, LONG Yan, SU Ke 767true ［Abstract］　Pneumonia is the common infectious disease of respiratory system and bacteria are the major pathogens. Determining the bacteria of pneumonia is significant for antimicrobial therapy. The diagnosis of bacterial pathogens in patients with pneumonia includes culture of bacteria, examination of bacterial antigen and detecting bacterial gene by polymerase chain reaction (PCR). The samples for bacterial culture consist of sputum, tracheal-bronchial aspiration collected through catheter or fiberoptic bronchoscope, bronchial alveolar lavage fluid, blood, pleural effusion and aspiration by transthoracic needle. The bacterial culture of sputum, blood and pleural effusion characterizes both simple techniques and low positive rates. Bacterial culture of aspirations gotten through catheter, bronchoscope or tranthoracic needle is sensitive and specific but invasive. Although the spectrum of detecting bacterial antigens in serum or urine and bacterial genes in sputum or urine is not satisfied, their high sensitivity and specificity would make them more common in clinical practice.]]> 2018/7/31 15:05:07 LU Ai-ling, QIN Zhi-qiang 766true ［Abstract］　Chronic kidney disease (CKD) has become an important disease that threatens global health. Its epidemiological survey methods is mainly the assessment of renal function and the detection of albuminuria in the population. National epidemiological survey showed the prevalence of CKD was between 8% and 15%.Its main risk factors include: increasing age, high blood pressure, high blood glucose, dyslipidemia, metabolic syndrome and so on. In this paper, the research progress on epidemiology investigation on method and the prevalence of CKD in recent years are reviewed.]]> 2018/8/1 8:23:53 TANG Sheng, GONG Zhi-feng 765true ［Abstract］　Ectopic pregnancy(EP) is a common emergency of obstetrics and gynecology.At present, ultrasonography has become an important tool in the diagnosis and treatment of EP. In this paper, the application progress on color Doppler ultrasound in diagnosis and treatment of EP in recent years was briefly reviewed.]]> 2018/8/1 8:23:53 SHEN Gui-xin, TAN Yi 764true ［Abstract］　The pulmonary embolism (PE) is a fatal illness, its clinical manifestation is of diversity, and lacks of the specificity. The rate of misdiagnosis of PE may reach as high as 70%～90%, and the case fatality rate as high as 25%～30% without being treated properly, while the case fatality rate may reduce to 6%～8% if it can be cured properly. This article makes a summary on the current related diagnosis and treatment of the PE.]]> 2018/8/1 8:23:53 HAN Xian, TAN Yi 763true ［Abstract］　Aurora A has emerged as a new family of mitotic serine/threonine kinases, which is associated with the function of centrosome.It is one of oncogenes which was found to overexpress in avariety of malignant tumors that are asssociated with the centrosome amplification, aneuploidy, and chromosomal instability.Aurora A has served as a new target for drug design as that lead to aneuploidy and tumorigenesis, the inhibitor,as VX-680 represents a new treatment of cancer.This review focuses on the research status of Aurora A in the pathogenesis of gynecologic malignancies.]]> 2018/8/1 8:23:53 LIU Ni-ping, ZHAO Ren-feng, WAN Ya-jun, et al. 762true ［Abstract］　Proprioceptive neuromuscular facilitation(PNF) is the cure method which combins action with the nerve, the muscle and the proprioception. It can improve the growth of nerves, originated by the physician and neurophysiologist Herman Kabat in 1940s. It is not only a medical technology, but also a brand new philosophic thinking; Its basic idea is that everyone-including the disabled persons has the no-choice rights of survival potential. Through ever-accelerated and improved, The PNF was proved to be a new issue being used widely in rehabilitation of the nerve disease, refering to the rehabilitation of orthopedics department, neurology department and infantile cerebral palsy. The paper makes an expectation and reviews of the meanings, techniques, mechanism and clinical study of PNF.]]> 2018/8/1 9:43:06 LI Rong-zhu, LV Ya-nan, CHEN Feng, et al. 761true ［Abstract］　The construction of medical key disciplines in china is need for the reform of medical and health service,this article elaborate on the creation,management,development,strategic position and effect about medical key disciplines.]]> 2018/8/1 9:43:06 ZHENG Cheng-jie 760true ［Abstract］　Early continuous blood purification （CBP） was used in the clinical treatment of patients with severe renal failure 。With the further development，CBP has been extended to the treatment of non-renal critical illness，become a common technique for ICU。This articles was reviewed CBP history and CBP application in non-renal critical illness.]]> 2018/8/1 9:43:06 XIE Jian，LU Yi-jun 759true ［Abstract］　Emergency percutaneous coronary intervention(PCI) of acute ST -segment elevation myocardial infarction is the most effective reperfusion and preferred strategy. However, the effects and clinical outcome of PCI will be significantly affected by the occurrence of no-reflow during operation.In this paper, we review the progress of prevention and therapy on no-reflow during emergency PCI.]]> 2018/8/1 9:43:06 YANG Wei-de, ZHENG Ping 758true ［Abstract］　Carbon dioxide pneumoperitoneum can distend the peritoneal space and reduce risk of intraoperative injuries of abdominal viscera.Its disadvantage is that it would have an impact on many organ systems of the body,and even lead to serious consequences. This article reviews the physiological effects of carbon dioxide pneumoperitoneum during laparoscopic surgery and lung protective measures during perioperative period.]]> 2018/8/1 9:43:06 FENG Ji-feng 757true ［Abstract］　Lipoprotein(a)［Lp(a)］ is an independent lipoprotein particle, composed of apolipoprotein(a)［Apo(a)］ and low density lipoprotein(LDL). Lp(a)′s concentration in serum is stable, cannot be changed with sex, age, diet, physical or chemical factors or drugs, is one of serum genetic marks. Reseach shows there is close relations between serum Lp(a) and diabetic nephropathy(DN). The level of Lp(a) in DN patients increase remarkably, and show positive correlation with urinary albumin excretion rate(UAER). Lp(a) damage kidney by many mechanisms. The analysis of Lp(a) in diabetes mellitus patients would be one of the adjunctive methods in the early diagnosis of DN. However, serum Lp(a) can increase in other renal diseases, cardiovascular diseases, disturbance of lipid metabolism and acute inflammation, more basic and clinical study are essential to improve the specificity of the detection.]]> 2018/8/17 8:09:35 ZHANG Chang-ming, LONG Yan 756true ［Abstract］　Hand-foot-and-mouth disease (HFMD) is a common febrile illness in young children and is characterized by lesions on the skin and oral mucosa. As infectious,the rate of HFMD remarkably increased at recent years.It is time for us to refocus on the oral lesions of HFMD. This article reviews clinical features and the advances in prevention and treatment about oral lesions of HFMD.]]> 2018/8/17 8:09:35 SHI Chun-mei 755true ［Abstract］　Severe brain injury is a severe damage of central nervous system. The patients are prone to pulmonary edema and lung infection.Hyperbaric oxygen treatment has been often stopped due to lung infection. This article summarizes the etiology,pathogenesis,treatment,and prognosis of the severe brain injury with pulmonary infection， and presents a hyperbaric oxygen therapeutic program for patients with severe brain injury complicated with lung infection in order to improve the cure rate.]]> 2018/8/17 8:09:35 XU Li-min 754true ［Abstract］　Although the incidence of cervical cancer in pregnancy is lower, but with advancing of age of the onset of cervical cancer and delaying of childbearing age, cervical cancer has become the most common malignant tumor during pregnancy. As cancer related to the health of the mother and fetus during pregnancy，in this paper the research progress on the diagnosis and treatment of cervical cancer in pregnancy in recent years is summarized.]]> 2018/8/17 8:09:35 LI Ning, WEI Yu-xiu, WANG Yan-jiao 753true ［Abstract］　Radiation therapy is one of the most important methods for malignant tumors. In radiation treatment, the normal tissues and important organs nearby inevitably receive exposure dose to a certain degree thus these tissues and organs are damaged to an extent especially when it comes to thoracic neoplasms. As thoracic neoplasms are often sharing neighboring relationships with the heart, it is not often luckily kept away from radiation field. Even if three-dimensional conformal or conformal modulating radiotherapy are applied, the heart is also more or less injured. In this paper, the pathogenesis of radiation-induced heart disease and its noninvasive examination were reviewed.]]> 2018/8/17 8:09:35 ZHANG Qin, YANG Su-ping, ZHANG Ya-Li 752true ［Abstract］　1,25-dihydroxyvitamin D3［1, 25(OH)₂D₃ ］ not only plays important role on calcium phosphorus metabolism, but also influences cell growth and differentiation, that will regulate immune system. The article reviewed mechanism on immunoregulation of 1, 25(OH)₂D₃, in order to develop more safe and effective analog applying on clinic as a new immunoregulant.]]> 2018/8/17 8:09:35 YE Kun, GONG Zhi-feng 751true ［Abstract］　IgA nephropathy is an immune complex disease, immune system imbalance, and cell dysfunction is involved in its pathogenesis. Different pathological types of IgA nephropathy have different clinical manifestations, and treatments are also different. Its occurrence may be associated with helper T cell 1 (Th1) and Th2 immune responses.This review is about the relationship between clinical pathology and Th cells research of IgA nephropathy.]]> 2018/8/17 8:10:44 HUANG Li, LI Jian-mei,TAN Rong-tong 750true ［Abstract］　AIDS is a contagious disease, with high mortality.There is currently no cure for this disease.It is a serious threat to social and economic development. Most of the natural course of the disease is in asymptomatic period.How to extend the asymptomatic period, slow progression of the disease, prolong life, is a major medical issue. Moxibustion therapy is safe and effective, simple, low cost,and has its unique advantages. Under the guidance of the “zhiweibing” thought of Traditional Chinese Medicine, early treatment of HIV infection with moxibustion, can dredge meridians, reconcile organs function, and stabilize or improve immunity, improve clinical symptoms and signs, and to reduce incidence of opportunistic infections and tumors. In short moxibustion can reduce patient morbidity and mortality,and improve the life quality.]]> 2018/8/17 8:10:44 LIU Zhen-wei, PANG Jun,LIANG Jian,et al. 749true ［Abstract］　Clopidogrel is one of the most widely used antiplatelet aggregation drug. The mechanisms of clopidogrel resistance (CPGR) are yet unclear to researchers. Possible mechanisms of CPGR include:polymorphisms of genes,platelet active factors,variable of bioavailability,factors of insulin resistance and aspirin resistance,noncompliance,dosing factors,drug interaction and so on.The appearance of CPGR had already influenced to its therapeutis effects. The article provides a brief review of new recognition and the progress of research for mechanisms of CPGR and measures of prevention and cure.]]> 2018/8/17 8:10:44 GONG Zhi-gang,TAN Yi 748true ［Abstract］　The operative space is established mainly by CO₂ insufflation in laparoscopic surgery. CO₂ insufflation may cause some complications and bad influences on human body. As a result, people invented all kinds of gasless device. In this paper, the influences of CO₂ insufflation on human body, the advantages and disadvantages of gasless methods and its development in laparoscopic surgery were reviewed.]]> 2018/8/17 8:10:44 WU Dong-bo, HUANG Shun-rong 747true ［Abstract］　Noncompaction of ventricular myocardium （NVM）is distinctly rare, and misdiagnosis and delayed diagnosis is more common. This review aimed at raising awareness and diagnosis of this disease through reviewed and summarized the characteristics and new progress of echocardiography and cardiac magnetic resonance, diagnostic criteria for NVM.]]> 2018/8/17 8:10:44 LU Yong-hua,ZENG Zhi-heng 746true ［Abstract］　Renal interstitial fibrosis(RIF)is the final common pathway by which all kidney diseases progress to the end stage of renal disease.Present study confirmed that the expression and abnormal activity of plasminogen activator inhibitor (PAI)play a vital role in the development process of RIF.This is a review of the role of PAI in the development process of RIF.]]> 2018/8/17 8:12:32 LIU Yan-hong,HAN Zi-ming 745true ［Abstract］　The polycystic ovary syndrome(PCOS) is a familiar endocrine obstacle disease which related to female reproduction and metabolism.Various endocrine hormone which interacted with or/and combined with endometrial receptors may make the endometrium of patients with PCOS manifested as abnormal secretory phase,simple endometrial hyperphasia,complex endometrial hyperphasia,atypical endometrial hyperplasia,even adenocarcinoma.The research on the effect mechanism of PCOS on endometrium is a hot spot of study at abroad in recent years.]]> 2018/8/17 8:12:32 LIU Ni-ping, PAN Hai-hua, MA Gang 744true ［Abstract］　As the widespread use of antibiotics eradicating Helicobacter pylori(Hp),the drug resistance rate of Helicobacter pylori(Hp) to metronidazole, clarithromycin and amoxicillin goes up year by year during 2006 to 2010 in China. It should be necessarry to stress the regional disparity and individual treatment in the area where there emerges drug resistance of Helicobacter pylori. And it should be necessarry to adopt various treatment strategies to improve the elimination rate of Helicobacter pylori.The treatment strategies include sequential treatment, four regimens extended regimen,antibiotics therapy using furazolidone, tetracyline and fluoroquinolone(such as levofloxacin and moxifloxacin) and interval 3～6 months therapy.]]> 2018/8/17 8:12:32 XIE Kun-hua,NONG Bing 743true ［Abstract］　AIDS, a malignant disease with high mortality, is one of the world′s most major infections diseases. We consider integrated traditional Chinese and western medicine in the prevention and treatment of AIDS can effectively enhance the effect of medicine and reduce the adverse reactions of anti-viral drugs, eliminate the clinical symptoms, improve patient compliance and quality of life, prolong survival time. There is some of the experiences from our center for AIDS research to explore the prevention and treatment of integrated traditional Chinese and western medicine.]]> 2018/8/17 8:12:32 DENG Xin, LIANG Jian,ZHANG Ya-ping 742true ［Abstract］　Over the years, with the exception of chronic myeloid leukemia where pathogenesis was found to be related with BCR-ABL fusion genes, the other MPNs′ pathogenesis remains unclear.In recent years, numerous studies confirm that high rates of mutation of JAK2 gene exists in multiple MPNs, and that the mutation may be the characteristic molecular markers of BCR-ABL negative MPNs.In this paper, the research progress on JAK2 mutations, latest diagnosis and targeted therapy of MPNs and so on in recent years are reviewed.]]> 2018/6/28 8:50:28 SANG Bao-hua，YANG Yue-huang，WEN Bo-ping 741true ［Abstract］　EB virus is the human herpes virus, closely related to some malignant tumours. EB viral load testing is currently widely used in the clinic, but due to the difference samples, or types of primer or probes, or nucleic acid extraction technology, or the use of equipment, or standards and standard curve, or reporting of test units, the inter-laboratory comparison were affected. In this paper, the impact factors of standardization of EB viral load testing were reviewed.]]> 2018/6/28 8:50:28 LI You-qiong, QIN Gui-fang 740true ［Abstract］　Ultrasound imaging technology is worth for diagnosis of breast neoplasm. It is a new method for evaluating microcirculation of blood flow perfusion. In this paper, the characteristics of tumor blood vessels, the superiority of contrast-enhanced ultrasound imaging and the application of ultrasound imaging in breast neoplasm are reviewed.]]> 2018/6/28 8:50:28 PEI Hua-jie, WANG Xiao-yan 739true ［Abstract］　Custom made fiber post is a new material developed in recent years. It is mainly made up with preimpregnated resin and reinforced fibers. The difference between custom made fiber post and traditional prefabricated fiber post is the former can be cut and partly shaped on demand. This paper is focused on the advance of basic and clinical studies about custom made fiber post.]]> 2018/6/28 8:50:28 PAN Xiao-bo,TAN Yi 738true ［Abstract］　Currently, with the application of a variety of new endoscopic techniques, we can get more intuitionistic and clear structures of gastric mucosa and submucosal structures, which made it possible for detection and diagnosis of early gastric cancer. In this paper, the progress of endoscopic diagnosis of early gastric cancer was reviewed briefly.]]> 2018/6/28 8:50:28 LU Rui-ming,NING Jian,TAN Yi 737true ［Abstract］　The dysfunctional uterine bleeding(DUB) is a common disease.The thermal balloon endometrial ablation is a new operation of DUB.The third generation thermal balloon endometrial ablation system in the treatment of DUB has the good clinical curative effect，and is safe and convenient. In this paper, its application status in menorrhagia is reviewed.]]> 2018/6/28 8:50:28 LIU Ni-ping,ZHAO Ren-feng 736true ［Abstract］　STR is becoming an main genetic market because of its extensive exist and polymorphisms. It has been applied in forensic medicine since STR detection makes great progress. The article concisely reviews its characteristics, related technologies and application in forensic medicine.]]> 2018/6/28 8:51:29 JIAO Wei, LIU Fei, TAN Yi 735true ［Abstract］　Intravenous analgesic used for postoperative analgesia is various,and the clinical effect is different. In recent years, for the patients who underwent surgical treatment, postoperative analgesia has become the routine. Intravenous administration method of analgesic in the postoperative analgesia is convenient and feasible,but on the choice of the analgesic, each hospital has all kinds of methods,that brought some confusion for clinicians. This paper reviews pharmacology and application status of intravenous analgesic commonly used in China, in order to provide help in medication use for clinicians.]]> 2018/6/28 8:51:29 ZHAO Zhi-gang,TAN Yi 734true ［Abstract］　Polycystic ovary syndrome (PCOS) is one of the principal causes of anovulatory infertility in reproductive age. The main endocrine characteristics of PCOS include hyperandrogenism, hyperinsulinemia,insulin resistance, the increasing level of luteinizing homone(LH), the increasing ratio of LH and follicle-stimulating homone(FSH). Recently research show that even the result of induced ovulation is satisfied, the prenant ratio is still low. Besides anovulation, there is another reason such as local endometrial factors that is related to infertility in PCOS. Abnormal endometrial environment resulted from endocrine disorder is a great disadvantage to embryo. Currently,the research for expression of insulin receptor protein in endometrium is a hot topic.]]> 2018/6/28 8:51:29 WU Yue-lian, LI Xue,ZHAO Ren-feng 733true ［Abstract］　Caries has been listed as one of the three diseases, which do great harm to the human health by WHO. Children have a high risk of develop dental caries. Therefore, caries prevention for children is very important. This review aims at introducing the advance in preventive technologies for primary teeth.]]> 2018/6/28 8:51:29 WANG Xiao-jie,XIAO Yi-fang,WEI Xue-hua 732true ［Abstract］　Althought bacterial culture of sputum has certain clinical significance to assist the etiology diagnosis of children community-acquired pneumonia, its reliability depends critically on the appropriate suction methods and skills. In this artical, we summary the suction methods used in pediatrics, and of which the factors affected the result of bacterial culture of sputum in community-acquired pneumonia children.]]> 2018/6/28 8:51:29 TANG Yiao-yan, XIE Qing-ling 731true ［Abstract］　The spread of AIDS has become a disaster. It caused the UN and governments around the world attaching great importance to research on the global AIDS response.This essay summarized that progress of AIDS response in the UN and developed countries, developing countries,China,etc.]]> 2018/7/2 15:40:24 WEI Hui-de,YANG Guang-he,HUANG Xiao-hong,et al. 730true ［Abstract］　High sensitivity C- reactive protein (hs-CRP) is an acute-phase protein, an important inflammatory marker. Many studies have shown, hs-CRP can be used for infectious diseases for early diagnosis, differential diagnosis, disease assessment, evaluation of efficacy,and also can be used for some non-infectious diseases. In this paper, research progress on the application of hs-CRP in pediatric disease is reviewed.]]> 2018/7/2 15:40:24 LIN Yu-feng,TAN Yi 729true ［Abstract］　Post stroke fatigue (PSF), which has a high incidence, is common symptoms of stroke. The pathogenesis of PSF was uncertain. There are no effective therapies to this disease now. Traditional Chinese medicine in the treatment of PSF has a great advantage. In this article the research progress in evaluation and treatment of PSF are reviewed.]]> 2018/7/2 15:40:24 TAN Kai-wen, TAN Yi 728true ［Abstract］　The most significant feature of female puberty is the emergence of menstrualtion. During this period, girls have great physiological changes that cause their thinking and emotional instablility, and affect their learning and physical and mental health. Menstrual health is an important part of adolescent health. The article focus on the present research status of common adolescent menstrual abnormalities and correlation factors.]]> 2018/7/2 15:40:24 LI Xue, LIU Ni-ping 727true ［Abstract］　With the popularization and the development of information technology，and the formation of the network environment，the traditional forms of hospital archives should be turn to the transition to digitized management,which is a inevitable trend. By carrying out of the digital construction of hospital technology archives,the integration of hospital archives and information, establishment of multi-channel, multi-channel, rapid and comprehensive inquiry system, the sharing of the hospital archives and information can be realized.]]> 2018/7/2 15:40:24 LEI Xiao-yun,WEI Hui-de 726true ［Abstract］　Polycystic ovarian syndrome (PCOS) is a common gynecologic endocrine disease， which can increase the incidence of infertility, diabetes, endometrial cancer and cardiovascular disease. The symptoms of adolescent PCOS and PCOS are similar, often with oligomenorrhea and (or) functional uterine bleeding, and even amenorrhea with obesity, polytrichosis, acne, etc. And some researches suggested PCOS is the continuation of adolescence PCOS. Early diagnosis and treatment on endocrine disorder and relative symptoms of adolescent PCOS play a certain effect on the control of the development of PCOS.The combination method of traditional Chinese and western medicine in the treatment of adolesent PCOS in recent years will be reviewed in this article.]]> 2018/7/2 15:40:24 ZHAO Zheng,WANG Lin 725true ［Abstract］　Sorafenib is a multikinase inhibitor that acts by inhibiting tumor growth and disrupting tumor microvasculature through antiproliferative and anti-angiogenic effects. It exerts these effects via inhibition of multiple targets including Ras/Raf/MAPK, VEGF/VEGFR and NF-κB signal pathways, which can be induced by radiation. Sorafenib combined with radiation in hepatocellular carcinoma treatment has been explored and shown synergistic results. The basic and clinical studies on the effects and mechanisms of the combining modality should be further investigated.]]> 2018/4/27 8:24:40 ZHENG Qing-ping, LI Jing 724true ［Abstract］　In the titanium mesh cage bone graft, the hollow cylindrical cage is used as scaffold, its center was paclded with crushed bones which can replace grafts and have an effect of decompression,then fastened by the anterior locking plate.In this way,it may reduce the disadvantages of the traditional anterior cervical operations.In recent years,this anterior way which aimes to shorten the operating time and decrease complications of the donor site is being applied more broadly in clinical treatment. In this paper,the summary is about the recent research status and progress of the titanium mesh cage bone graft and locking plate using in the anterior cervical operation.]]> 2018/4/27 8:24:40 LIANG Hui,WEI Jian-xun,LI Rong-zhu 723true ［Abstract］　The significance of right ventricular function in diagnoses and therapy of chronic pulmonary heart disease is increasingly given attention. Now two-dimensional echocardiography, M-mode echocardiography, Doppler ultrasound，tei index, quantitative tissue velotity imaging, strain and strain rate imaging, automated border detection, contrast echocardiography, three-dimensional echocardiography are applied in evaluation of right ventricular function. The progress metioned above is reviwed in this article.]]> 2018/4/27 8:24:40 LIANG Na,TAN Yi 722true ［Abstract］　This paper reviews the progress in surgical techniques of congenital scoliosis, including in situ posterior spinal fusion surgery, the convex side of epiphysis block surgery,posterior instrumentation correction and fusion surgery, hemivertebra resection, spinal osteotomy technology, growth stick technology,thoracic expansion forming operation, vertical expansion opened and the thorax titanium rib prosthesis surgery.]]> 2018/4/27 8:24:40 XIE Zhao-lin,JIANG Jian-zhong,TAN Hai-tao,et al. 721true ［Abstract］　Drug-induced liver injury is due to the toxic effects of drugs and their metabolites or body allergic reaction to drugs, which cause liver injury. According to the U.S. statistics, the most common reason that drug withdrawal from the market is liver toxicity, and 50% of acute liver failure was caused through improper medication. The antineoplastic agents, similar to other drugs, can cause liver that from non-specific biochemical changes to acute or chronic hepatitis, even liver failure and cirrhosis. The selection of a chemotherapeutic regimen for the oncology patient is based on a thorough assessment of potential hazards relating to the patient′s clinical condition and the toxicities of chemotherapy. Therefore, comprehensive understanding of hepatotoxic manifestations for the most common chemotherapeutic agents is essential,that aims to predict, prevent these severe reactions,and ultimately make chemotherapy success.]]> 2018/4/27 8:24:40 MA Yu-hua,ZOU Ya-wei,CHEN Fu-xiong 720true ［Abstract］　Small cell lung cancer relapses after first-line chemotherapy quickly, it induces multidrug resistance after recurrence easily,so that part of the patients is less sensitive to the second-line treatment. In recent years,some chemotherapies and new targeted drugs were used in research of maintenance therapy of small cell lung cancer, but the function and status of maintenance therapy in small cell lung cancer are still debated. In this paper, the research progress on the maintenance therapy of small cell lung cancer is reviewed.]]> 2018/5/14 8:34:42 PENG Wei,FENG Guo-sheng 719true ［Abstract］　Insulin receptor substrate (IRS ) is an important signaling proteins in insulin signal transduction pathways. IRS-1 plays an important role in skeletal growth, bone turnover and bone fracture healing. It may be a new point for the prevention and treatment of metabolic bone disease and osteoporosis.]]> 2018/5/14 8:34:42 HE Yu-ling,ZHOU Hou-de 718true ［Abstract］　Hyperbaric oxygen therapy (HBOT) is the primary or adjuvant therapy for acute and chronic diseases. Studies recently have proved that HBOT is not only useful for chronic glomerulonephritis, nephritic syndrome, diabetic nephropathy, acute renal failure, ischemia reperfusion injury of kidney etc, but also has potential effects in the treatment of other kidney-related diseases. HBOT plays more and more important role in the treatment of kidney diseases. The research progress of HBOT for kidney diseases would be summarized in this paper.]]> 2018/5/14 8:34:42 LIU Gang, LUO Quan-hai, CHEN Fu-chang,et al. 717true ［Abstract］　Diabetic nephropathy (DN ) incidence rate is increasing year by year, early diagnosis is crucial for its treatment and prognosis. Urinary albumin excretion rate (UAE) is an important indicator in the early diagnosis and prognosis of DN. But the UAE can only be used for diagnosis of DN afterⅡ～Ⅲstage of DN. In recent years the study on early diagnostic methods of DN has been in rapid development, a lot of new diagnostic strategies are proposed.In this article the early diagnosis strategies of DN presented at home and abroad in recent years is reviewed.]]> 2018/5/14 8:34:42 TANG Guo-chuan,GONG Zhi-feng 716true ［Abstract］　Cerebral venous thrombosis(CVT) was a rare thrombosis occurred in intracranial vein or venous sinus caused by various factors. In this article, the etiologies, mechanisms,diagnosis,clinical manifestations, treatment and prognosis of CVT were reviewed.]]> 2018/5/14 8:34:42 HUANG Zai-wen,ZHONG Wei-zhang 715true ［Abstract］　AIDS and TB (AIDS/TB) dual infection is the most common opportunistic infection, but so far, humans have not yet developed effective drugs to kill the human immunodeficiency virus (HIV). With the transformation of the medical model, how improve the quality of life of AIDS patients has been increasingly concerned. The study about the quality of life and psychological support of AIDS becomes hot point at home and abroad in recent years, while the research about quality of life and psychological support of AIDS/TB is less reported.]]> 2018/5/14 8:34:43 PAN Cai-fang,TAN Yi 714true ［Abstract］　Luteotropic hormone ( LH) has an important role in induced ovulation and controlled ovarian hyperstimulation in human assisted reproduction. The roles of LH in supporting follicular development were reviewed briefly.]]> 2018/5/14 8:35:38 HE Bing,CHENG Jun-ping, HUANG Li,et al. 713true ［Abstract］　Rituximab is a kind of anti CD20 monoclonal antibody which can specifically bind with CD20 antigen on B lymphocyte surface. It can be used for the treatment of B cell associated diseases.At present the clinical application of rituximab is more and more extensive. It achieved good clinical results. This article will briefly reviews its clinical application.]]> 2018/5/14 8:35:38 HUANG Xiao-chun,TAN Yi 712true ［Abstract］　Sudden cardiac death（SCD） is one of the major causes of human death. This article reviews the research progress on the aetiology, mechanism, treatment and epidemiology of SCD.]]> 2018/5/14 8:35:38 WEI Kai-fu, QIN Shao-ming 711true ［Abstract］　Adenomyosis refers to one sort of benign lesion caused by the endometrial glands′ and stroma′s invasion into the myometrium, and its main performance is excessive menstrual flow, dysmenorrhea, and infertility. For the patients with adenomyosis who want to keep their uterus, if the effect of the simple drug treatment is not satisfied, they can choose a conservative surgery: including excision of the lesion of adenomyosis, endometrial and myometrial resection, electric coagulation of myometrial lesions, surgery combined with drug treatment, pelvic denervation therapy, the uterine artery occlusion, interventional treatment, etc. The choice of surgical methods depends on patient′s age, will, fertility requirements, the location and scope of the lesion and the doctor′s surgical skills. In this paper, the current application stutus of conservative surgery for adenomyosis is briefly reviewed.]]> 2018/5/14 8:35:38 WEI Jian-wei,ZHAO Ren-feng 710true ［Abstract］　Capillary leak syndrome (CLS) is a group of clinical syndromes in critical patients.The patient′s condition is serious and the CLS′changes in pathophy is complicated.The clinical manifestations of CLS include systemic edema,low blood pressure,hyoxemia,hypoproteinemia,oliguria and so on.The occurrence of CLS often has a difinite incentive cause,including severe infection,severe trauma,poisoning and so on.The diagnosis of CLS is based mainly on clinical manifestation and laboratory examination.The treatments include controlling primary disease,liquid treatment,and improving the capillary permeabilety and so on. Understanding CLS′ pathogenesis and giving the right treatment will be useful in the reversal of CLS.In this paper,the clinical research progress on the cause,pathogenesis,diagnosis and treatment of CLS is briefly reviewed.]]> 2018/5/14 8:35:38 FU Xi-bo,TAN Yi 709true ［Abstract］　Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary cardiomyopathy, which is characterized by the replacement of right ventricular cardiocytes by fibrous and adipose tissue. The clinical manifestations include repeated arrhythmias, heart failure and sudden cardiac death, and with the important status of sudden cardiac death in young people and athletes. Therefore, it is necessary to deepen the recognization and the future research about the pathology, pathophysiology and clinical characteristics of ARVC. This article is to review the clinical characteristics, electrocardiogram manifestation, ultrasonic cardiogram and MRI characteristics of ARVC.]]> 2018/5/14 8:35:38 HUANG Jun-zhang,FU Chun-hui 708true ［Abstract］　There is compelling evidence that depression is an independent risk factor for both the development of coronary heart disease(CHD) and the worsening prognosis. This paper raviewed the mechanisms of impact of depression on CHD including biological mechanisms, behavioral mechanisms, adherence to treatment and social support, and the treatment measures including antidepressant drugs, cognitive behavioral therapy, and physical activity and so on in the management of patients with co-morbid depression.]]> 2018/5/14 8:35:39 ZHANG Yun, HUANG Gui-zhong 707true ［Abstract］　The body position management of pregnant women has important clinical significance. It ensure effectively pregnant women during pregnancy and perinatal period relative comfort, safety, effectively prevent complications, effectively correct fetal position, greatly enhance the possibility of giving dystocia into the natural birth,thereby lowering the rates of dystocia and cesarean section, improving the delivery quality and ensuring safety of mother and infant.The recent advances on body position management of pregnant woman in obstetrics are reviewed in this paper.]]> 2018/5/14 8:35:39 LIAO Dong-lin, LIAO Ling, TAN Yi 706true ［Abstract］　Refractory wounds in diabetic patients is a serious Complication.There is some difficulties for its treatment. The recent studies have showed traditional Chinese medicine in the treatment of diabetic refractory wounds has better therapeutic effects. In this paper, the research progress on the mechanism of traditional Chinese medicine in the treatment of diabetic refractory wounds is briefly reviewed.]]> 2018/5/14 8:35:39 WU Zheng-qiu,LIANG Zi-qian 705true ［Abstract］　Infarction refers to ischermic necrosis of brain tissue or encephalomalacia elicited by blood supply disturbance to the brain.It has higher mortality rate and disability rate and threatens the patient′s health and the life seriously. In recent years the application of traditional Chinese medicine in the treatment of cerebral infarction has obtained certain achievements. In this article, the progress of its research were reviewed.]]> 2018/5/14 8:35:39 LI Ding-feng, TAN Yi 704true ［Abstract］　Minimally invasive pedicle screw internal fixation is a new minimally invasive spine technology.In recent years,it is extended to the treatment of thoracolumbar fractures and lumbar segmental instability and so on.It has the advantages of small incision,less invasion damage,minimal blood loss and rapid postoperative recovery.In this paper,its clinical application is reviewed.]]> 2018/5/21 9:01:32 WEI Jian-xun,LI Rong-zhu 703true ［Abstract］　Rheumatoid arthritis(RA) is a common disabling autoimmune diseases.Traditional drugs treatment for RA include nonsteroid anti-inflammatory drugs,corticosteroids and so on.Lots of patients can′t get satisfied control for the condition of refractory RA,and result in severe joint damage.Biological agents have revolutionized the treatment of RA.These agents play an important role in the control of rheumatic conditions and the improvement of quality of life in RA patients.]]> 2018/5/21 9:01:32 SHI Yu-hong,TAN Yi 702true ［Abstract］　Smoking is an important danger factor of many diseases. Smoking cessation is important method of decrease tobacco related disease. The pharmacological interventions can help smokers in cessation. The first-line smoking cessation medication include nicotine replacement therapy (NRT), bupropion and varenicline. This paper reviews the progress of research and application on smoking cessation drugs.]]> 2018/5/21 9:01:32 LIANG Da-hua,TAN Yi 701true ［Abstract］　Thoracolumbar fracture is the common spinal injury and an important research topic in the field of orthopedics. In recent years, as the research progress on imaging and biomechanics, the therapies and technologies for thoracolumbar fracture has also made some progress. This article reviews the research progress on treatment of thoracolumbar fracture,including surgical and non- surgical treatment.]]> 2018/5/21 9:01:32 XIAN Jing-feng,TAN Yi 700true ［Abstract］　Traditional Chinese medicine is the treasure of the Chinese medicine and culture.With the rapid development of modern medical science, traditional Chinese medicine is facing the serious challenge and competition day by day.Traditional Chinese medicine has to meet the need for development and innovation to keep their own eternal charm, and it′s rely on the innovative talents. Reviewing the research route of domestic Chinese medicine innovative talents in the recent 10 years, exploring its main problems in research of the introduction, cultivation and management and use, analyzing its research results, and exploring the future research direction of traditional Chinese medicine in Guangxi innovation talent management,all have a very important significance to promote the development of the cause of Guangxi traditional Chinese medicine.]]> 2018/5/21 9:01:32 HUANG Li-xue,TANG Hong-zhen,CHEN Xian-han,et al. 699true ［Abstract］　Hemostasis is a fundamental principle of surgery. This article summarized application characteristics of the surgical electrocoagulation, ultrasonic scalpel and ligasure, combined with the method of gastric cancer operation, and proposed the theory of surgical technique without ligation. The related issues were reviewed.]]> 2018/5/28 8:15:14 XU Sheng, HUANG Shun-rong 698true ［Abstract］　The diagnostic of the coronary heart disease is always the first step of the clinical procedure. With the rapid development of the medical imaging technology hardware and software, CT coronary artery angiography becomes possible and realizing non-invasive coronarography. CT coronary artery angiography may play an important role in coronary artery stenosis judgment, coronary plaques diagnosis, calcium scoring, and left ventricular heart function analysis after stent placement, and therefore, CT coronary artery angiography is taking place of coronarography in certain area. This article will analyze the application of MSCT in the diagnostic of coronary heart disease.]]> 2018/5/28 8:15:14 MA Chun-yan,TAN Yi 697true ［Abstract］　Antiplatelet agents can effectively decrease the thromboembolic events， but increase the risk of gastrointestinal bleeding due to mucosal damage， therefore antiplatelet agents are commonly used with proton pump inhibitors （PPI） to reduce the risk； as they shared the same metabolic pathway in the liver， recent studies show that treatment with clopidogrel plus PPIs can increase the incidence of adverse cardiovascular events. Despite being controversial, this finding has attracted wide attention from clinicians. This article will review the recent advances in clinical research on the interaction between PPI and clopidogrel.]]> 2018/5/28 8:15:14 MA Li-qun,TAN Yi 696true ［Abstract］　Mycoplasma is the smallest prokaryotic microorganisms, Ureaplasma urealyticum(Uu) is one of the most common pathogens causing urogenital tract infections. Collecting the relevant literature at home and aboard,the mechanisms of antibiotic resistance of macrolides, tetracyclines, quinolones in Uu were intruducing in this paper.]]> 2018/5/28 8:15:14 TAN Chun-yan,ZHOU Ying,TAN Yi 695true ［Abstract］　As the common complication of cerebrovascular disease, dysphagia increases gradually with the increase of incidence rate of cerebrovascular disease. Dysphagia can cause many complications, such as aspiration pneumonia,intake disorders of water and nutrition, asphyxia, mental disorders and so on.These complications badly affect living qualities of patients. Meanwhile, they also increase the disability rate and the fatality rate. In this article,the authors systematically reviewed the progression of study on etiopathogenesis,clinical manifestation,diagnosis,prevention and treatment of dysphagia due to cerebrovascular disease in the past ten years.]]> 2018/5/28 8:17:42 LIU Shi-dan,CHEN Qi-bo, LI Rong-zhu,et al. 694true ［Abstract］　Chronic hydrocephalus can cause mental retardation, abnormal gait, urinary incontinence of patients, and increase the burden on society and family. This paper focuses on progress the causes, diagnosis and treatment of chronic hydrocephalus after aneurysmal subarachnoid hemorrhage.]]> 2018/5/28 8:17:42 CHEN Xiu-qing, ZHANG Yu-hua, TAN Yi 693true ［Abstract］　With fast development in molecular biology and medical genetics, prenatal diagnosis is becoming rapid,sensitive and non-invasive techniques, more and more birth defects has been diagnosed in early stage of embryonic development. With the advent of chromosome-specific probe and development of DNA technique, fluorescence in situ hybridization (FISH) has widely been used in clinical as a molecular diagnostic technology by providing intuitionistic and rapid diagnosis. In the paper, the research progresses of FISH in the rapid prenatal diagnosis are discussed.]]> 2018/5/28 8:17:42 MO Yao-xi, MO Wei-ying,TAN Yi 692true ［Abstract］　Pelvic floor dysfunctional（PFD ） diseaseis a common disease among elderly women. pelvic organ prolapse may occur in 50% of pluripara. The middle compartment dysfunction is mainly presented with uterine or vaginal vault prolapse and rectal uterine pouch hernia formation, for which the common treatments are abdominal sacrocolpopexy, McCall Culdeplasty and high uterosacral ligament suspension（HUS）, sacrospinous ligament fixation（SSLF）, posteriorintravaginal slingplasty（P-IVS）, total pelvic reconstruction etc. In this paper,the surgical indications, surgical methods, complications,prevention and treatment are reviewed.]]> 2018/5/28 8:17:42 SU Qing-hong,TAN Yi 691true ［Abstract］　Respiratory failure is a common clinical syndrome，the effect of sole conventional drugs therapy is very limited. With the growing understanding of respiratory physiology, the great improvement of non-invasive ventilator and gradual extending indications of non-invasive ventilation (NIV), NIV has been widely used in the different respiratory failure. Many studies have revealed its effects on respiratory failure: improved the respiratory physiology, reduced the rate of endotracheal intubation, lowered hospital mortality and decreased complications of invasive mechanical ventilation（IMV）. The progress of NIV in respiratory failure in recent years is reviewed.]]> 2018/6/4 8:29:26 LONG Xiao-ping, QIN Zhi-qiang 690true ［Abstract］　Several methods are available to the upper ureteral calculi. Previously, open surgery is a alternative to the patients with upper ureteral calculi who failure to the treatment of conservative treatment. With the rapid development of minimally invasive technology in the field of urinary surgery, several new techniques are used in the clinical practice, such as extracorporeal shock wave lithotripsy (ESWL), ureteroscopy (URS), minimally invasive percutaneous nephrolithotomy (MPCNL), percutaneous nephroscopic holmium laser lithotripsy, ureteroscopy holmium laser lithotripsy and retroperitoneal laparoscopic ureterolithotomy(LUL). The development and prevalence application of new minimally invasive technology lead to the less use of open surgery. However, because of the special space position structure of upper ureteral calculi, there are remaining the debates on the choice of minimally invasive technology, there is a review of the development situation of minimally invasive technology in the treatment of upper ureteral calculi.]]> 2018/6/4 8:29:26 LI Bi-jin,TAN Yi 689true ［Abstract］　The method of DNA quantitative cytology is one of the newest technique in cervical cancer screening during the passed decade,accepted by clinical medical staff widely step by step.It depends on the basic theory of cancer molecular cytogenetics.This is a review of the application theory and the perspective of DNA quantitative cytology.]]> 2018/6/4 8:29:26 MO Wei-jie,WU Yue-lian,ZHAO Ren-feng 688true ［Abstract］　Multiple sclerosis(MS) is a most common chronic inflammatory demyetinating disease of the central nervous system. The most frequently involved sites are brainal periventricular white matter,optic nerve,spinal cord,brain stem and cerebellum. Its etiology and mechansim of pathogeness are yet unclear to reseachers. MS is slowly progressive disease and the treatment for MS need a long-term process. At present, the durgs can′t completely cure the disease. Relapsing remitting MS(RRMS) is the most common type of MS which accounts for about 80%～85%. The treatment of acute phase and remission phase of MS will help to reduce the relapsing, slow the progress of the disease and improve the quality of life of patients. The progress of researchs in this field is reviewed.]]> 2018/6/4 8:29:26 GONG Qiu-ming,TAN Yi 687true ［Abstract］　The uroschesis is the symptom that the urocyst is full of urine but fail in micturition,it is one of the most common complications after the operation for anorectal diseases.There are several factors which will cause uroschesis,and the methods of treatment and nursing are various.This article will introduce the causes of the uroschesis after the operation for anorectal diseases as well as the treatment and nursing measures.]]> 2018/6/4 8:29:26 NING Xian-fen,TAN Yi 686true ［Abstract］　maspin is a tumor suppressive gene and plays an important role in promoting tumor cells apoptosis, suppressing tumor cells mobility, invasive, metastasis and angiogenesis. The expression of maspin gene is precisely controlled by several pathways. But the role of maspin in liver cancer is poorly investigated.In the paper,the progress on the mechanisim of tumor suppression of maspin gene and its role in liver cancer were reviewed.]]> 2018/6/4 8:30:03 LIU Jin-xin,TAN Yi 685true ［Abstract］　Percutaneous vertebroplasty(PVP) is a new minimally invasive spine technology. In recent years, PVP gradually is extended to the treatment of spinal hemangioma, myeloma, osteolytic metastases and osteoporosis, vertebral compression fractures patients with intractable pain. It has the advantages of simple operation, less invasive demage, quick effect and low complication rate. In this paper, its clinical application are reviewed.]]> 2018/6/4 8:30:03 GAN Feng-ping,TAN Yi 684true ［Abstract］　Premature delivery means that the delivery appears between over 28 pregnant weeks and 37 pregnant weeks.In the case that fetus survives, no fetal distress appears, fetal membranes are not broken,application of inhibitors of uterine contractions is the key to treatment of premature delivery. This article briefly reviews the reseach progress of inhibitors of uterine contractions in the treatment of premature delivery in recent year.]]> 2018/6/4 8:30:03 ZHU Li-xin,TAN Yi 683true ［Abstract］　About 70% of severe acute coronary events in patients with coronary artery disease are caused by vulnerable plaques (VP). The rupture of unstable plaques is core mechanism of occurrence of acute coronary syndrome (ACS) and which effects is more important than that of degrees of coronary artery stenosis and ranges of illness with coronary artery in occurrence of acute cardiovascular events. The modern progress of imaging technology, especially intravascular ultrasound (IVUS) and optical coherence tomography (OCT), provides supports of fast and reliable information for identification and judgment of morphologial features of VP, including form, composition, and even function condition of VP. In diagnosis and evaluation of coronary artery plaques, the detection level of OCT with high distingnish rate is nearing the detection level of the histology, and then possessed with important clinical siginificance. In this paper,the progress on detection technology of VP morphology and new recognition are reviwed simply.]]> 2018/6/4 8:30:03 ZENG Xian-you,ZHU Ji-wen,LIU Zhi-hong 682true ［Abstract］　Immediate breast reconstruction with implant after mastectomy is the most common type of breast reconstructions, and the surgical technique is relatively easy to learn, easy to promote, and easy to implement, with wide indication, slight trauma, mild pain, short operative time, early recovery, little scar, rapid postoperative recovery, fewer complications that are easy to handle, and many other advantages. In recent years, it has been widely used in China. In this paper relevant recent advances will be reviewed, with respect to the changes in the number, the evaluation, and existed problems that reported in the literature about the immediate breast reconstruction with implant after mastectomy for patients of breast cancer.]]> 2018/6/22 16:33:56 ZHANG Hai-tian,LU Yun-fei 681true ［Abstract］　After the brief introduction of Das-Naglieri cognitive assessment system (D-N:CAS) based on the PASS theory and the constitution of the process-based reading enhancement program (PREP) which are matching to D-N:CAS, the application status of domestic and overseas on D-N:CAS and PREP were reviewed in this paper.]]> 2018/6/22 16:33:56 QIN Ling,WU Xin,DENG Ci-ping 680true ［Abstract］　Cyclosporine A plays an important role in anti-rejection reaction after organ transplantion. Cyclosporine A can induce gingival overgrowth. It will affect oral hygiene and beauty.It also can affect chewing and pronouncing. This article reviewed the clinical pathology and the mechanisms of gingival overgrowth induced by CsA.]]> 2018/6/22 16:33:56 WEI Yi, ZHOU Yan 679true ［Abstract］　Hand- foot - mouth disease(HFMD) is an emerging infectious one,and most of cases are not serious. However, some serious cases usually affect infants′ and children′s nerve system, circulatory system, and respiratory system,causing encephalitis, myocarditis and pulmonary edema etc. Sometimes the disease comes quickly and has a high death rate as well as a short window of opportunity for treatment. What the doctors in primary level hospitals should do is how to indentify early signs and symptoms of serious HFMD disease and pick out the serious patients and give them a right diagnosis,a transfering consultation or a treatment as soon as possible. This text mainly summarizes the early signs and symptoms of serious HFMD so that it can give the doctors in primary level hospitals a help.]]> 2018/6/22 16:33:56 MO Zeng-luan, LAN Ke-zhang 678true ［Abstract］　Cerebral ischemic stroke has high incidence rate, morbidity, mortality, and high recurrence rate. The vulnerable atherosclerotic plaque of carotid artery is the main factor that influence ischemic stroke. So it is great significant to early identifying carotid vulnerable plaque for acute stroke prevention. This article reviews the progress in the diagnosis of vulnerable plaque from the aspects of ultrasound, CT angiography, MRI, digital substraction angiography and molecular imaging.]]> 2018/6/22 16:33:56 LI Lan-qing,ZHONG Wei-zhang 677true ［Abstract］　Perimenopausal syndrome (PMS) is one of common gynecological diseases, which seriously bothers women and creates huge stressful burden on the home caregivers as well as the society, attracted the attention of numerous scholars and clinical workers, has become a research hot topic of gynecological diseases at home and abroad. There are a variety of methods to treat the PMS, mainly including general treatment, hormone replacement therapy, Chinese medicine, combined therapy of traditional Chinese and Western medicine, psychotherapy, comprehensive Treatment, etc. This paper reviews to the research advancement in the clinical treatment of PMS.]]> 2018/6/22 16:33:56 LUO Hong-ling,TAN Yi 676true ［Abstract］　Primary central nervous system lymphoma(PCNSL)is a rare form of non-Hodgkin lymphoma (NHL)that is restricted entirely to CNS without evidence of systemic spread and that has aggressive biological behavior.Due to absence of typical clinical presentation,multiple neuroimaging appearance,heterogeneity of pathological morphology and without specific laboratory examination so on,the immunohistochemistry and molecular biology are of vital importance in accurate diagnosis of this disease.At present,the methods of treatment include operation,chemotherapy,radiotherapy,immunotherapy and so on.The excision of intracranial tumor is discussed.Although the introduction of systemic chemotherapy and radiotherapy has consistently improved survival,the prognosis of PCNSL is still poor.This paper reviews the research progress on diagnosis and treatment of PCNSL.]]> 2018/4/8 15:34:47 HUANG Ling-tuan,TAN Yi 675true ［Abstract］　Hyperlipidemia is one of the leading cause of severe acute pancreatitis (SAP). Hyperlipidemic severe acute pancreatitis (HL-SAP) frequently shows a severe and life-threatening clinical condition,with high case fatality rate. The current therapy is mainly individualized by quickly lowering the level of blood lipids,prevention and treatment of HL-SAP relevant complications. All the effort is aim to decrease the case fatality rate of HL-SAP.This paper reviews the progress on diagnosis and treatment of HL-SAP.]]> 2018/4/8 15:34:48 FENG Meng-die,TAN Yi 674true ［Abstract］　Acute ischemic cerebrovascular disease,the main reason of disability, is a serious threat to human health, with a high morbidity and mortality. There is no specific treatment method for this kind of disease at present.In this paper, the current situation and progress in treatment of acute ischemic cerebrovascular disease at home and abroad in recent years are reviewed in order to provide thinking and reference for the treatment of acute ischemic cerebrovascular disease.]]> 2018/4/8 15:34:48 LUO Qing-yan,LUO Yong-Jian 673true ［Abstract］　Adenoidal hypertrophy in children is a common cause of obstructive sleep apnea hypopnea syndrome, developmental disorders, memory loss, secretory otitis media. The choosing basis of the clinical treatment methods of children adenoidal hypertrophy is the radiological diagnosis. The pathological and anatomical basis and the progress of radiological diagnosis of adenoidal hypertrophy in children were reviewed in the paper.]]> 2018/4/8 15:34:48 CHEN Jun,PENG Bei,TAN Yi 672true ［Abstract］　Diabetes mellitus,one non-infectious disease,is currently considered as one main killer to human health by the international community. Detection of glycemia is particularly important to diabetic diagnosis and treatment, and prevention of its acute and chronic complications. HbA1c can reflect the level of glycemia during the past 2～3 months. And it has been recommended as a diagnostic test of diabetes mellitus at present. Now the detection method and the clinical significance of HbA1c is summarized in this paper.]]> 2018/4/8 15:34:48 LI Xiao-lin,QIN Xiong,Ouyang Lin-li 671true ［Abstract］　High sensitive C-reactive protein(hs-CRP) is an acute-phase proteins,an important inflammatory marker.Many studies have shown that hs-CRP can be used for early diagnosis,differential diagnosis,disease assessment,evaluation of efficacy in infectious diseases,and also can be used for some non-infectious diseases .In this paper,research progress on the application of hs-CRP in medical diseases is reviewed.]]> 2018/4/8 15:34:48 ZHU Zhu-hua, TAN Yi 670true ［Abstract］　Self-ligating bracket is a new low friction bracket,it used its brackets self-lock structure to replace or decrease the archwires ligations using wire or rubber band in the conventional brackets.The self-ligating brackets have the advantages of lighter force,lower friction with archwires,more easy for teeth move and cut down the untoward effect to oral tissue during the orthodontic treatment,more convenient for clinical operation and shorter treatment time.In this article,the classification,properties and the newest clinical effects of self-ligating brackets are summarized.]]> 2018/4/11 8:05:22 LU Shi-ying,TAN Gui-ping,HUANG Min-fang 669true ［Abstract］　The C-arm X-ray machine as a mobilizable X-ray machine consists of the parts of optical system, parts of machine and image processing systems. In recent years, with the gradual improvement of surgical technique, C-arm X-ray machine, increasingly, has taken a more and more important role in orthopaedic surgery. C-arm X-ray machine which has the effect of perioperative positioning, surgical restoration and internal fixation with timely image data is a kind of common imaging device in orthopaedic surgery. It gives surgical treatment a great convenience,but also puts forward a higher requirement to the orthopaedic surgery.The application of C-arm X-ray machine in orthopaedics is review in this article.]]> 2018/4/11 8:05:22 ZENG Jia-xing, LIANG Bin 668true ［Abstract］　Polycystic ovary syndrome(PCOS) is an endocrine disorder syndrome in which reproductive dysfunction and metabolic abnormalities coexist. In order to improve ovarian function and treat infertility, firstly comprehensive treatment should be performed according to patients′condition in endocrinology and metabolism to correct systemic conditions.If the patient remains infertile after above treatment, it is suggested that the patient should be treated by various assisted reproductive methods, including ovulation induction, surgery and assisted reproductive technology. In this paper, progress on clinical treatment study of infertility patients with PCOS is reviewed.]]> 2018/4/11 8:05:22 LIANG Lian-hong,TAN Yi 667true ［Abstract］　Information visualization is used to map scientific pictures of the large literatures by using software, so as to reveal the internal connecting link and research spot and frontier in a clear way. The paper outlines the definition, characteristic, common software and summarizes the progress of information visualization on the biomedicine to lay the foundation of this technique on the field of biomedicine.]]> 2018/4/11 8:05:22 HUANG Xin, HU Bang-li, DENG Li, et al. 666true ［Abstract］　L-amlodipine is amlodipine pharmacological section, with high vascular selectivity and long half-life, persistent effect, less adverse reactions, convenient medication, widely used for clinical treatment of cardiovascular disease, such as hypertension, left ventricular hypertrophy, angina, atherosclerosis and so on. On the basis of reference of the research literature of L-amlodipine in the last few years,its application status in cardiovascular diseases is reviewed.]]> 2018/4/11 8:05:22 WANG Huan,PAN Li,TAN Yi 665true ［Abstract］　Pulsatile tinnitus is an uncommon otologic symptom, which often presents a diagnostic and treatment dilemma to the otolaryngologist. The majority of patients with pulsatile tinnitus have a treatable cause. Failure to establish correct diagnosis may have disastrous consequences, because a potentially life-threatening, underlying disorder may be present. The purpose of this review is to familiarize the otolaryngologist with the most common causes, evaluation, and treatment of pulsatile tinnitus.]]> 2018/4/11 8:05:22 WANG Tao,TAN Yi 664true ［Abstract］　Mangiferin is a flavonoid compound and has a variety of physiological and pharmacological effects. Recent studies have reported that mangiferin has anti-tumor effect. Mangiferin anti-tumor mechanism includes inhibition of tumor cell proliferation and growth, blocking the cell cycle, induction of apoptosis, inhibition of NF-κB signaling pathway activation, interference in E-cadherin-mediated cell adhesion and signal transduction, intervention of mitochondrial permeability transition and the combined effects of chemotherapy drugs.]]> 2018/4/27 8:23:45 LIU Xiao-chun, JIAO Wei 663true ［Abstract］　Adult avascular necrosis of femoral head(ANFH) is caused by different causes, its pathogenesis is not very clear. A brief overview of the research progress of ANFH in epidemiology,pathogenesis, staging, diagnosis, treatment is made in this article.]]> 2018/4/27 8:23:45 TAN Zhen, SU Wei 662true ［Abstract］　The decrease of apoptosis rate of cells is the main mechanism of tumors,The inhibitor of apoptosis protein plays important role in suppressing apoptosis of cells.X-linked inhibitor of apoptosis protein(XIAP) is one of the most important members of IAP family.It inhibits cell apoptosis mainly by inhibiting the caspases activation and interfering with other apoptotic pathway.This article reviews the recent advances in the research on its molecule structure,expression and function mechanism,relationship with digestive system tumors and so on.]]> 2018/4/27 8:23:45 WANG Juan-juan, ZHANG Guo,ZHANG Fa-can 661true ［Abstract］　In recent years, with improvement of people′s living standards, the morbidity of gestational diabetes mellitus（GDM）and impaired glucose tolerance is increasing. Consequently, the perinatal mortality, morbidity, as well as the obstetric complications are growing in number. This review will focus on the morbidity, outcome of GDM, along with home nursing intervention measure for postnatal GDM patients.]]> 2018/4/27 8:23:45 TAN Xiao-yan,YAN Xiao-dong 660true ［Abstract］　The alcoholic avascular necrosis of femoral head has been witnessed an increasing trend in recent years. However, there still has been no breakthrough in the clinical treatment because of the limitations of the current animal models, which also leading to the unsatisfied research of the causes of the disease and pathogenesis. This paper reviews the present situation and progress of research in the alcoholic avascular necrosis of the femoral head.]]> 2018/4/27 8:23:45 LI Hong-yu, CAI Min, TAN Yi 659true ［Abstract］　Respiratory failure is common in chronic obstructive pulmonary disease (COPD) and usually needs ventilation, which includes non-invasive ventilation (NIV). Clinical studies have confirmed that the NIV can benifit the respiratory function, improve the parameters of arterial blood gas analysis and reduce the endotracheal intubation rate in the patients with acute respiratory failure in actue exacerbation of COPD. NIV can also improve the parameters of artierial blood gas analysis, quality of life and excercise tolerance of patients with chronic respiratory failure in stable COPD. Severe acidosis, hyperglycaemia and more severe conditions are the predict factors of poor NIV outcome. This paper reviews the research progress on the non-invasire ventilation for the treatment of respiratory failure in chronic obstructive pulmonary disease.]]> 2018/1/29 9:17:02 QIN Zhi-qiang, TAN Yi 658true ［Abstract］　Post-traumatic epilepsy is one of the most serious complications of traumatic brain injury, and its basic research is becoming more and more attention, but the pathogenesis is unclear. This paper describes the possible pathogenesis of post-traumatic epilepsy: the epileptic focus ultrastructural changes including changes in neurons, glial cells and the blood-brain barrier, apolipoprotein E allele ε4(APoE-ε4), iron and free radical damage, excessive release of excitatory amino acids(EAAs), hippocampus synaptic reconstruction and so on.]]> 2018/1/29 9:17:02 XU Qi-ling,YAN Li,TAN Yi 657true ［Abstract］　Chronic wound has very complicated pathogenesis and is difficult to treat.In particular,chronic wounds often lead to loss of functional ability,increase pain and reduce quality of life,and can be a burden of medical care.This situation has been improving owing to the progress in wound healing research and the clinical application of new techniques.This paper focuses on the progress of its pathogenesis and treatment in chronic wound.]]> 2018/1/29 9:17:02 LIU Qiang, SHAO Jia-Song 656true ［Abstract］　Female pelvic floor dysfunction(FPFD) is one of the ordinary diseases in aged women. The disease has a severe influence upon the life and intercourse of the patients.The clinical advance in treatment on FPFD was reviewed in this paper.]]> 2018/1/29 9:17:02 WU Yue-lian, LIN Hai-yan,ZHAO Ren-feng 655true ［Abstract］　Patients feel heavy pain after orthopedics operation, and effective treatment and nursing intervention on pain can relieve the pain in a certain degree.Therefore, some methods can improve the success rate of operation and reduce the incidence of complications in the process of pain, including nursing after orthopedics operation, strengthening the doctor-patient communication,changing idea about postoperative pain management,choosing appropriate analgesia mode according to the evaluation of pain degree, following up the efficacy and analgesic effect.This paper briefly reviewed the research progress on postoperative pain nursing of orthopedic operation.]]> 2018/1/29 9:17:02 HUANG Xue-lian,TAN Yi 654true ［Abstract］　Autoantibodies refer to the resistance of immune globulins to their own intracellular antigens, the cell surface antigen and the extracellular antigen; They are one of the key characteristics for autoimmune and autoimmune diseases. Antinuclear antibodies are the total autoantibodies of intracellular antigenic components. Some autoimmune diseases contain characteristic autoantibodies. The marked autoantibodies or special autoantibodies can be used for diagnosis and differential diagnosis of the disease characters. Autoantibodies can be estimated for activity and prognosis of diseases, responsed to therapies, and guided for clinic treatment as well. Further antinuclear antibody spectrum research can clarify the relationship between the antinuclear antibodies and autoimmune diseases. Thus, this paper clarifies the relationship between antinuclear antibody, auto antigen and diseases.]]> 2018/2/5 8:39:48 LI Yan-mei,TAN Yi 653true ［Abstract］　Acute cerebral infarction refers to local ischemic necrosis or softening of the brain tissue caused by the blood supply disturbance, ischemia, hypoxia. Its morbidity, mortality, and the incidence of complications and recurrence rates in the elderly are very high in China. Statins can be used for the treatment and prevention of acute cerebral infarction. This paper reviewed the research progress on its action mechanism.]]> 2018/2/5 8:39:48 PANG Yu,TAN Yi 652true ［Abstract］　The highly active antiretroviral therapy ( HAART ) is the only cure for AIDS at present, but the related factors influencing the efficacy of antiviral therapy for AIDS are relatively complex.This paper is a summary of the related factors affecting the efficacy of antiviral therapy for AIDS.]]> 2018/2/5 8:39:48 CAO Yong-hong,ZHANG Yong,TAN Yi 651true ［Abstract］　Leakage is one of the most common complications in intravenous infusion（IVI） in the outpatients. This paper mainly reviews its influencing factors, preventive strategies and nursing measures.]]> 2018/2/5 8:39:48 WEI Lin-yan,TAN Yi 650true ［Abstract］　Recent literatures of acupuncture and rehabilitation in the treatment of post-stroke dysphagia were reviewed. Acupuncture combining with rehabilitation is the best treatment of dysphagia induced by post-stroke pseudobulbar paralysis,which plays an important role in reducing disability and improving the quality of life for patients with dysphagia.]]> 2018/2/5 8:39:48 CHEN Qi-bo,TAN Yi 649true ［Abstract］　Neonatal respiratory failure(NRF), one of the most common emergency and severe diseases in neonatal period, is the main cause of neonatal death. Its fatality rate is high.Therefore, how to improve the treatment and reduce the fatality rate has become a hot topic in neonatology. In recent years, with the progress of diagnostic and therapeutic technology, the treatment effect of NRF has been improved accordingly.In this paper, a brief overview on research progress in the treatment of NRF was reported.]]> 2018/2/5 8:39:26 YANG Wan-qing, TAN Yi 648true ［Abstract］　Hydrocephalus is one of the common diseases in neurosurgery. The use of ventriculoperitoneal shunt has changed the prognosis for patients with hydrocephalus. Shunt infection remains an important, distressing cause of shunt failure and puts the patient at high risk of intellectual impairment and even death. This paper summarizes the recent research status and progress of the ventriculoperitoneal shunt infection.]]> 2018/2/5 8:39:26 XU Ke-bei, TAN Yi 647true ［Abstract］　Intracranial atherosclerotic stenosis is an important etiopathogenisis in stroke. In spite of development, it still remains controversial to prevent recurrent stroke in a long-term outcome using stenting.In this paper,we overview stent application from its development history, types and SAMMPRIS study.]]> 2018/2/5 8:39:26 CHEN Yuan, ZHONG Wei-zhang 646true ［Abstract］　Fetomaternal Hemorrhage (FMH) defines as the fetal blood（≥30 ml usually） across the placental barrier into the maternal circulation before or during delivery. With FMH>150 ml, perinatal morbidity increases, with FMH>250 ml, the risk of death or damage to the fetus is very high. FMH is rare, and difficult for diagnosis and treatment. In this review, the origin of the disease, the progress of its etioyogies,diagnosis and management have been summarized.]]> 2018/2/5 8:39:26 TIAN Mao, TAN Yi 645true ［Abstract］　Atlas which connects skull with cervical vertebra is at the corresponding parts of the spinal cord center of life, and its anatomical location is significant. Once atlantoaxial dislocation or atlanto-occipital instability occurs, it can directly compress the medulla oblongata and endanger the lives of patients. Therefore, the effective fixation of the atlas site is crucial. Posterior atlantoaxial screw-plate fixation is an emerging posterior atlantoaxial fixation technique, by which the screws are fixed in the atlas and axis. This technique has the character of easier operation and good fixing performance. In this paper, the research progress on the feasibility and clinical applications of atlas posterior screw fixation technique are reviewed.]]> 2018/2/5 8:39:26 LI Shu-wei,TAN Yi 644true ［Abstract］　Intraoperative awareness, which refers to varying degrees of the patient′s perception during general anesthesia, is a serious complication of anesthesia. It often causes serious mental and psychological trauma in the patients, and some serious consequences may occur. Perioperative nurses are the first medical staff that contact with the patients after the operation, and stand in a unique position to assess whether the patients have experienced intraoperative awareness, and help them cope with the mental and psychological trauma, reduce occurrence of sequelae like traumatic stress disorder syndrome. Effective assessment and nursing interventions are important to improving the quality of life in patients with intraoperative awareness. This paper reviews the research progress on assessment and nursing interventions of intraoperative awareness in patients undergoing surgery during general anesthesia.]]> 2018/2/5 8:39:26 YU Yao,TAN Yi 643true ［Abstract］　It has always been a difficult issue to repair and reconstruct the defect or stricture of long ureter. The clinical treatment methods are various,but each treatment has its own advantages and disadvantages. New tissue engineering material provides a complete new way for regeneration of ureter. In this paper, the progresses and problems of various operation modes and the application of tissue engineering in repairing ureter are summarized.]]> 2018/2/23 15:16:37 BI Ge-wen, TAN Yi 642true ［Abstract］　Female pelvic floor dysfunction is a common disease in the middle-aged and old women.There is a direct relation between the occurrence of this disease and the abnormal support structure of pelvic floor. Some new ultrasonic technologies，especially the three -dimensional ultrasound imaging，have brought new opportunities for the research and clinical application of pelvic floor structure. This article briefly reviewed the progress of clinical application of three- dimensional ultrasound in female pelvic floor dysfunction.]]> 2018/2/23 15:16:37 NONG Mei-fen, WANG Xiao-yan, TAN Yi 641true ［Abstract］　Extraction of mandibular impacted third molars, especially in the middle level or lower level, is complicated in alveolar surgery. The conventional extraction procedure could lead to many complications（for example dry socket）,and has some shortcoming， such as severe alveolar and temporomandibular trauma, long time in operation, pain, etc. Minimal invasive tooth extraction opens a new era of extraction. This paper discusses the concept and skills of minimally invasive extraction technology,and its application in the extraction of mandibular impacted third molars in order to provide a reference for the further popularization of minimally invasive extraction technology.]]> 2018/2/23 15:16:37 GUO Hong-jian, LIANG Fei-zhao, LI Gang 640true ［Abstract］　Severe traumatic brain injury（sTBI） is one of the the common critically ill in neurosurgery clinic,with the complicated condition, the difficult treatment, the high mortality rate. The treatment is mainly to adopt an integrated approach. For many years, the exploration and study of the neurosurgery experts at home and abroad has made great achievements on the treatment of severe traumatic brain injury, but there are still great difficulties and uncertainties,so its treatment is still the current research topics in neurosurgery field. This article focuses on the summary of recent years’ progress in treatment of severe traumatic brain injury.]]> 2018/2/23 15:16:37 WEI Ying-guang, TAN Yi 639true ［Abstract］　The intima-media thickness and plaque of carotid is closely related with various diseases，it is given attention more and more.Ultrasonography can make a appraisal and prognosis about various diseases and be widely used clinically.This paper reviews the progress in clinical application about ultrasonography for the intima-media thickness and plaque of carotid.]]> 2018/2/23 15:16:37 LIAN Cheng-kai，CHEN Cheng-hai 638true ［Abstract］　The application of percutaneous Kypho-plasty(PKP) is the main skill in the treatment of vertebral compression fractures.This method not only has advantages of few operation time, simple operation,significant analgesic effect and so on,but also can corret patients’ kyphosis. However,like vertebroplasty(PVP),there are also complications of bone cement leakage, vertebral fracture again and vein thrombosis. With the development of technology, and based on this some new developed technologies,such as the PKP combination postural reset, eggshell technology, Sky and Vessel-X bone material filling percutaneous vertebroplasty surgery and so on, have greatly improved some defects which existed in balloonetechnology,including cement leakage and so on. In this paper,the progress in clinical application of this technology,including indications,operation method,complication and its prevention,some new technologies and so on are reviewed.]]> 2018/2/23 15:17:06 LIANG Hui, LI Rong-zhu, WEI Jian-xun, et al. 637true ［Abstract］　The study has found that reactive oxygen species has certain correlation with male infertility. How to prevent excessive generation of reactive oxygen species and remove excessive reactive oxygen species is one of the hot spot of the research in recent years. This article reviews the research progress on the effect of reactive oxygen species on sperm physiology and pathology, the source and detection methods of the semen reactive oxygen species,the effect of reactive oxygen species on assisted reproduction and so on.]]> 2018/2/23 15:17:06 SHI Ming-hua, LI Mu-jun 636true ［Abstract］　T helper cell 22(Th22) is a new subset of T cells.They mainly secrete interleukin(IL)-22，IL-13 and IL-6,but not interferon-γ(IFN-γ) or IL-4 or IL-17，and exert their function mainly via IL-22.They can mediate inflammatory reactions,autoimmune diseases,tumors，etc，and play an important role in immune regulation,host defense and tissue repair.This paper reviewed the research progress of Th22.]]> 2018/2/23 15:17:06 LU Shan-he, LIN Ying-zhong 635true ［Abstract］　Endometrial receptivity refers to endometrial ability in accepting embryonic implantation,which has a great impact on the success rate of embryonic implantation. A good endometrial receptivity can improve the success rate of embryonic implantation. Studies have shown that traditional Chinese medicine have better effect in improving endometrial receptivity. In this paper, the research progress on traditional Chinese medicine in improving endometrial receptivity in recent years was briefly reviewed.]]> 2018/2/23 15:17:06 HUANG Zhong-yan, ZHAO Gan, XIANG Jian-mao, et al. 634true ［Abstract］　Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Surgery and chemotherapy are the main methods in therapy of NSCLC. The study and identification of predictive targeting molecules and markers of chemosensitivity of NSCLC will be beneficial to customized treatment of NSCLC patients. This article will review the research status about excision repair cross complementation group 1(ERCC1) as a predictive marker for chemotherapy of NSCLC.]]> 2018/2/23 15:17:06 QIN Guo-liang, XIAN Lei 633true ［Abstract］　Care and support for AIDS patients have become important elements of AIDS prevention, this paper analyzes ongoing situation of HIV/AIDS care, puts forwart existing problems and provides recommendations for future HIV/AIDS comprehensive care to improve multidisciplinary HIV/AIDS comprehensive care model.]]> 2018/2/23 15:17:06 WEI Cai-yun, DONG Wen-yi,LAN Jiang 632true ［Abstract］　The morbidity of tongue carcinoma is on top of oral cavity carcinoma,which has many characters including high malignancy,strong infiltration.The metastasis and recurrence is the main factors responsible for fatalities of tongue carcinoma patients. Metastasis and recurrence of tongue carcinoma has always been a great research hotspot of oral and maxillofacial surgeons, and its related gene molecule has also become the hot topic and difficulty in recent years.This paper reviewed metastasis and recurrence-related gene molecule of the tongue carcinoma.]]> 2018/2/23 15:17:06 LI Li-chu, WANG Shu-ting,SUN Jin-hu 631true ［Abstract］　Acute coronary syndromes(ACS) are a common emergency of coronary heart disease, inflammation plays a key role in atherosclerosis.3-hydroxy-3-methylglutary coenzyme A reductase inhibits statins has been widely used in the primary and secondary prevention of coronary heart disease.Accumulating evidence has revealed that statins have a significant anti-inflammatory effect.This paper briefly reviewed the research progress on the anti-inflammatory mechanism of statins in ACS.]]> 2018/3/12 9:42:55 LOU Wei-ming,TAN Yi 630true ［Abstract］　New-type drugs keep a close and complicated relationship with HIV/AIDS, New-type drugs can increase the risk of HIV infection by reducing the function of the immune system, and it can promote HIV replication. It also has effects on clinical manifestations, serologic testing results and therapeutic responses of HIV/AIDS. This paper reviewed the association between new-type drugs and HIV/AIDS.]]> 2018/3/12 9:42:55 XIANG Shao-mi, NONG You-feng, ZHOU Mei,et al. 629true ［Abstract］　Arsenic is a toxic metal existed in nature widely. Arsenic excessive will endanger human health or even cause cancer. Selecting proper, simple, reliable method for the determination is an essential condition of modern trace analysis technology achieving significant development. The determination of trace arsenic in recent years are reviewed, including arsenic stain method, spectrophotometry, catalytic polarographic method, atomic absorption spectrometry, inductively coupled plasma mass spectrometry, and the application prospect of hyphenated techniques in the separation and determination of arsenic speciation is prospected in this paper.]]> 2018/3/12 9:42:55 QIN Li-mei, SU Xu 628true ［Abstract］　Anal fissure, one of the most common diseases in coloproctological department, has seriously affected the patient’s quality of life. Internal sphincterotomy is common used method for anal fissure，but it has many types of procedures and some methods work better than others. This paper reviewed the advances on the applications of internal sphincterotomy in the treatment of anal fissure.]]> 2018/3/12 9:42:55 MO Shu-quan,TAN Yi 627true ［Abstract］　Adverse effects may appear in sublingual immunotherapy (SLIT ) of allergic rhinitis, so it’s critical to improve nursing to increase the safety of this treatment. We reviewed here the factors influencing the safety of sublingual immunotherapy, including the therapeutic environment, nursing staff quality, patient factors and medication guidance and so on, and outline the strategy for improving the patient management, with the aim of increasing safety of sublingual immunotherapy in clinical practice.]]> 2018/3/12 9:42:55 LI Feng-ti, ZHANG Yue-min, LU Qiu-tian 626true ［Abstract］　Pulmonary embolism (PE) is a common disease with high mortality. Pulmonary angiography is the gold standard for definite diagnosis, but that is difficult to perform in primary hospital or after working time. Non-special techniques such as arterial blood gas analysis, plasma D-dimer, serum cardiac enzyme, electrocardiogram, chest rediography, echocardiography, vascular ultrasonography and clinical model may result in a diagnosis of PE directly or diagnostic clues. The development of non-special techniques in PE diagnosis is reviewed in this paper.]]> 2018/3/12 9:42:55 CHEN Gui-rong, QIN Zhi-qiang 625true ［Abstract］　Ischemic stroke is one of the diseases which is serious hazard to human health, and the research of its prevention and mechanism has been one of the hot spots of medical research today. Currently, the symptomatic treatment of both ultra-early thrombolytic therapy and nutrition brain cells are focused on rescuing dying neurons, and reducing the death of neurons, protecting the nerve function. Angiogenesis (AG) is the structure basis for resistance to damage of the organization which is lack of blood and neuron repair, and after treatment of ischemic cerebrovascular disease AG can promote central nervous system regeneration. The harmonious role of many molecules in cerebral ischemia is helpful to AG after cerebral ischemia. The research of AG confirms that the cell membrane microcapsules protein-1(Caveolin-1) plays a key role.The latest research of correlation between Caveolin-1 and angiogenesis would be summarized in this paper.]]> 2018/3/12 9:43:40 ZHOU De-sheng,KOU Zhi-gang,CHEN Yao,et al. 624true ［Abstract］　Primary hepatocellular carcinoma（HCC）is one of the most common malignant tumors which is serious threatening people’s health,and its pathogenesis is still unclear so far. Research shows that 8-hydroxy-2′-deoxyguanosine(8-OHdG) play an important role in the carcinogenesis mechanism and development of HCC as the representative product of oxidative DNA damage.This paper reviews the present advances of research on 8-OHdG expression in HCC.]]> 2018/3/12 9:43:40 TANG Yi，LIU Li-li，TANG Yun-tian 623true ［Abstract］　With the development of modern diagnosis and treatment techniques, the use of vascular interventional therapy becomes widespread. Large doses of iodinated water soluble contrast media （CM） are often administered during neural interventional procedures. Then the incidence of contrast-induced nephropathy（CIN) is increasing now. CIN has become the third cause of hospital acquired renal failure and the second most important reason of drug-induced renal failure. How to preventing CIN effectively during interventional procedures is increasingly subject to the attention of the medical profession. This paper reviewed the risk factors and pathogenesis, as well as the early renal damage markers，prevention and cure of CIN.]]> 2018/3/12 9:43:40 WANG Shu，WANG Da-cheng, TAN Yi 622true ［Abstract］　Prehypertension is the transition area between hypertension and normal blood pressure, often associated with a variety of risk factors of cardiovascular and cerebrovascular disease, likely progressed to clinical hypertension, increased the incidence of cardiovascular and cerebrovascular diseases. The United States’ guidelines for prevention and treatment of high blood pressure (JNC-7) proposed prehypertension as a new concept, recommend that this kind of crowd can reduce the risk of cardiovascular and cerebrovascular disease through lifestyle modification. In this paper, the reaserch progress on the prevention and treatment of prehypertensicn is reviewed.]]> 2018/3/12 9:43:40 ZHANG Ru-ling, TAN Yi 621true ［Abstract］　Polycystic ovarian syndrome (PCOS) is common in adolescent girls with unclear etiology and complex clinical manifestation and is difficult to be distinguished from normal adolescent appearance. It is often be omitted. So the early diagnosis and timely treatment of adolescent PCOS is very important. With the technique development，especially the emergence of high throughout sequence platform，research on PCOS has been revolutionized. This article reviewed new progress of etiology, pathogenesis, clinical manifestations and treatment of adolescent PCOS.]]> 2018/3/12 9:43:40 XIE Yan-hua,TAN Yi 620true ［Abstract］　Missed abortion refers to intrauterine embryo or fetus that is not timely discharged after death.Its causes are multifactorial.This review presents recent research advances in the development of missed abortion in associated with excessive apoptosis of trophoderm cell.]]> 2018/3/21 8:06:39 WU Yu-ying, CHEN Chang-yi 619true ［Abstract］　Bone morphogenetic protein-4 (BMP-4),named BMP-2B else,is number of transforming growth factor beta(TGF-β) superfamily,which not only has the promotion ability of human embryonic development and cell proliferation, differentiation and apoptosis, but also has an important effect on tumor proliferation, invasion and metastasis.In this paper, the latest progress on research of BMP-4 and BMP-4 receptor expression in breast cancer and its signal transduction pathway, influencing factors and function was reviewed, in order to understanding a possible molecular mechanism for the development of breast cancer.]]> 2018/3/21 8:06:39 LI Ke, XU Wei-yun 618true ［Abstract］　Varicocele(VC) is one common cause of male infertility. A lot of research of its mechanism has been concluded.On the basis of the literature in recent years, pathogenesis, diagnosis and treatment progress of VC infertility was reviewed, in order to improve the level of clinical diagnosis and unified diagnostic and treatment practices.]]> 2018/3/21 8:06:39 ZHANG Wei-guo,WANG Xiao-ping 617true ［Abstract］　Colligated features of epidural anesthesia and spinal anesthesia, combined spinal-epidural anesthesia(CSEA) have advantages of short onset time, exact effect of blockage, small dose of local anesthetic, controllable time, etc. CSEA has been widely used in clinical anesthesia. The review mainly described the background and history of CSEA, summarized its clinical application in elder patient anesthesia. Complications of CSEA and their prevention measures were also discussed.]]> 2018/3/21 8:06:39 ZHONG Ying,TAN Xian-hu 616true ［Abstract］　Brain edema induced by intracerebral hemorrhage is a common pathology process which can be divided into cell toxicity brain edema and vasogenic brain edema. The degree of edema occupied a very important position in the mechanism of cranial nerve damage secondary to cerebral hemorrhage.AQP-4 as transport passage of water and some small molecules channels, may increase cell toxicity brain edema, reduce vasogenic brain edema.Its mechanism may be related to the space specificity and time-dependence of the expression AQP-4. Ca²⁺ as a second messenger in cells, participates in the neurotransmitter’s synthesis and release, the increase of its content can increase brain edema and make AQP-4 expression rising. AQP-4 as a signal access may also play a role in regulation of Ca²⁺. This paper reviewed the relevant research in recent years.]]> 2018/3/21 8:07:41 ZHOU De-sheng,LIU Li-juan,CHEN Yao,et al. 615true ［Abstract］　Posterior circulation is also known as the vertebrobasilar artery systern.Atherosclerotic vertebrobasilar artery stenosis is the major cause of posterior circulation ischemia,endovascular intervention has received more and more attention，and it has become the most promising therapeutic approach.In this paper,the current situation of stent-assisted angioplasty for symptomatic vertebrobasilar artery stenosis is reviewed.]]> 2018/3/21 8:07:42 HUANG Guang-jian, ZHONG Wei-zhang 614true ［Abstract］　With the widespread use of continuous glucose monitoring system (CGMS)，it was noticed that blood glucose fluctuation is easier to induce the occurrence and progression of diabetic microangiopathy than persistent hyperglycemia. Calcitonin gene-related peptide（CGRP）is presently known as the most powerful vasodilator peptide in the body which plays an important role in diabetic microangiopathy. It was believable that proper consciousness of the glucose fluctuation and deeper study of the CGRP may provide a new method of diagnosis and treatment for diabetes mellitus (DM), which will lead to prognosis improvement.]]> 2018/3/21 8:07:42 WANG Ya-jiao，LONG Yan，SU Ke 613true ［Abstract］　Cough variant asthma (CVA) is a special asthma presenting chronic cough as the main or only clinical symptom. It is similar of the pathogenesis and pathology & physiology of CVA and classial asthma (CA). The common characteristic of CVA and CA are persistent airway inflammation, airway hyperrespensiveness and airway remodeling. An average of about 30% of pediatric patients with CVA eventually develop into CA. Leukotriene (LTs) is one of important inflammatory mediators in vivo. LTs and its antagonist (LTRAs) play an important role in the pathogenesis and treatment of CVA. Early intervention is clinic important for countermeasure about treatment of CVA. LTPAs is a safe and effective choice.This paper reviewed the research progress on the relation between CVA and LTs.]]> 2018/3/21 8:07:42 FANG Fen,TAN Yi 612true ［Abstract］　Bacterial two-hybrid system and DNA site-directed mutagenesis technique have become important technical means of disease molecular genetics research. In this paper, the united technique of bacterial two-hybrid system and DNA site-directed mutagenesis technique in recent years was briefly reviewed.]]> 2018/3/21 8:07:42 LU Wen-sheng, CHENG Hua 611true ［Abstract］　Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is the most effective method to treat patients with leukemia. The indication and effect of transplantation is different in the different type of leukemia. Conditioning regimen is decided according to the disease condition of the patient. Infection，the graft versus host disease(GVHD) and hepatic veno-occlusive disease(HVOD) are the major complications associated with transplantation. This review focuses on the advance of allo-HSCT in the treatment of leukemia.]]> 2018/1/24 8:18:05 LAN Mei，LIN Jin-ying 610true ［Abstract］　Chronic pharyngitis is a common disease, difficult to treat, it is caused by irrational dietary factors, pharyngeal infection factors surrounding adjacent organs, allergic factors, psychological stress factors, chemotherapy, radiation injury factors, occupational factors, environmental factors. Chronic pharyngitis can also occur alone, but also with other systemic diseases concurrently. This paper reviewed the research progress in cause,prevention and treatment of chronic pharyngitis.]]> 2018/1/24 8:18:05 MENG Hui-ju,LIANG Yi,HE Yue-jie,et al. 609true ［Abstract］　In recent years, non-invasive positive pressure ventilation has been widely used,particulary in chronic obstructive pulmonary disease(COPD) patients with respiratory failure.Non-invasive positive pressure ventilation could improve lung function and the quality of life, reduce the incidence of ventilator-associated pneumonia(VAP) in the sequential invasive and non-invasive mechanical ventilation, reintubation rate and reduce the morality rate in COPD patients with respiratory failure. This paper focuses on the summary of non-invasive positive pressure ventilation in COPD patients with respiratory failure.]]> 2018/1/24 8:18:05 LONG Sheng-ze, LONG Sheng-gui 608true ［Abstract］　Nutritional risk screening tool made by European Society for parenteral and enteral nutrition(ESPEN) is based on evidence-based medicine,that is Nutritional risk screening method 2002(NRS2002),is an effective tool to predict the clinical outcome of hospitalized patients and determine whether nutrition intervention is needed,which is recommended as a nutritional risk screening tool of first choice for hospitalized patients.Nutritional risk refers to the risk of clinical complications related to nutritional factors,not the risk of malnutrition.Discovering the nutritional risk can predict the clinical outcome and monitor the efficacy of nutritional support in patients.But in current domestic nutrition support treatment these still exists irrationality in the clinical application.The aim of this paper is to review the NRS2002 method and the clinical nursing application at home,in order to provide a reference for clinical practitioners.]]> 2018/1/24 8:18:05 HUANG Yun-hua,SONG Huai-yu,LI Ning,et al. 607true ［Abstract］　Intracranial pressure(ICP) monitoring has been used for decades in the fields of neurosurgery and neurology. There are multiple techniques: invasive as well as noninvasive. This paper aims to provide an overview of the recent research status and progress in monitoring of ICP.]]> 2018/1/24 8:18:05 XU Ke-bei,XIAO Quan,YE Jing 606true ［Abstract］　The identification methods of umbilical cord blood mesenchymal stem cell include morphology, ultrastructure, and cell phenotype and cytokines and gene, but there is no consensus on these methods, and there is still no golden standard.In this paper, the relevant literatures about the identification of the umbilical cord blood mesenchymal stem cell are summarized.]]> 2018/1/24 8:18:34 XUE Xing-ying,XIAO Rong-chi 605true ［Abstract］　Benign prostatic hyperplasia(BPH) is a common urinary disease in aged men. The urinary obstructions of some patients usually need to be relieved by surgery. The surgical options of BPH include open surgery and endoscopic surgery. Endoscopic surgery is the major method for treating BPH. Transurethral resection of the prostate remains the gold standard for treating BPH. However, many new endoscopic methods appear in recent years with the progression of technology. This paper gives a brief review on the progression of endoscopic therapy for BPH.]]> 2018/1/24 8:18:34 YU Hai, LIANG Jian-bo, LI Wei 604true ［Abstract］　Homocystein(HCY)is the product of intermediary metabolism of methionine demethylation. Usually,the level of plasma HCY exceeding 10 μmol/L is called hyper-homocysteinemia(HHCY). The essential hypertension with HHCY is defined as H-type hypertension. Hypertension and HHCY as double risk factors significantly increased the risk of cardiovascular and cerebrovascular events. This paper provides an overview of the definition of H-type hypertension, the metabolic pathways of HCY, existence forms of HCY in the plasma,clinical significance and control strategy of H-type hypertension, in order to improve cognition and attention on H-type hypertension and eventually reduce the risks of cardiovascular and cerebrovascular events.]]> 2018/1/24 8:18:34 CHEN Wen-bo,TAN Yi 603true ［Abstract］　With the aging of our population, the female pelvic floor dysfunction(PFD) have become increasingly prominent, seriously affecting middle-aged women′s health and quality of life. Early diagnosis and prompt treatment is extremely important for PFD. In recent years, along with a variety of treatments, especially patch technology, treatment of PFD disease has been new progress. In this paper, new progress of etiology, diagnosis, treatment options in PFD disease are reviewed.]]> 2018/1/24 8:18:34 LING Dan，ZHAO Ren-feng 602true ［Abstract］　Senile osteoporotic vertebral compression fractures(SOVCF) is one kind of common fractures in elderly patients with osteoporosis,often leading to kyphosis,causing pain and dysfunction. In this paper, the general situation on the research progress in the treatment of SOVCF was briefly reviewed.]]> 2018/1/24 8:18:34 LV Liang-qing,WEI Xiang-dong,MENG Shi-yuan,et al. 601true ［Abstract］　Type 2 diabetes has been linked with colorectal cancer closely. There is high colorectal tumor risk in type 2 diabetic patients.However, the possible molecular mechanisms of relationship between the two diseases are not clear yet. The progress of molecular mechanisms was reviewed in this paper.]]> 2018/1/29 9:14:33 TENG Jia-an, YANG Rui-ping 600true ［Abstract］　Perioperative hypothermia influences coagulation function and leads to more blood loss during and after operation. The factors influencing perioperative hypothermia mainly include the temperature of operating room, anesthesia and other factors. We reviewed the research on the causes and mechanisms of perioperative hypothermia, and its effect on coagulation function and prevention.]]> 2018/1/29 9:14:33 HUANG Yu, YIN Dong 599true ［Abstract］　Diabetic cardiovascular and cerebrovascular disease, peripheral vascular disease are the major causes of death and disability in patients with diabetes. Artery calcification is one of the basic pathophysiology of diabetic angiopathy. This review presented recent research advances in relationship between bone-related protein and artery calcification in diabetes.]]> 2018/1/29 9:14:33 CHEN Hui, YAN Xiao-dong 598true ［Abstract］　Blood pressure variability(BPV) is one of the physiological features of blood pressure(BP), and it is an index used to describe the fluctuation BP in a period of time.The abnormal fluctuation in BP or abnormal increase in BPV can cause damage to the heart,brain,kidney and carotid artery etc, and has impact on overall prognosis of the patients with hypertension. To recognize BPV and its damage to the target organs should be a great help to the prevention of the target organs damaged in the patients with hypertension and improve their quality of life and the prognosis.In this paper,the methods of analysis and monitoring of BPV,and the relationship between BPV and target organ damage in patients with hypertension were briefly reviewed.]]> 2018/1/29 9:14:33 AI Yun-fang, TAN Yi 597true ［Abstract］　Ischemic cerebrovascular disease is a serious disease which threatens to human survival and quality of life. The advantages of cerebral vascular interventional treatment are less invasive, more effective, quicker recovery,etc. Inspite of various complications, intervention treatment is still the primary treatment of ischemic cerebrovascular disease. The safety and efficacy of surgery depends not only on the strict standard operation, but also on the prevention of complications and nursing master.This paper veview progress on nursing care for complications of interventional therapy of ischemic cerebrovascular disease.]]> 2018/1/29 9:14:33 MO Li,TAN Yi 596true ［Abstract］　The Ebola hemorrhagic fever (EBHF) is a severe infectious diseases,with its high fatality rate up to 90%.There have been 9 times of outbreak about EBHF and some limited epidemic or sporadic cases from 1976 to now. The first time were happened in Former Zaire and Sudan. From February this year, EBHF broke out and spread from Guinea to Liberia, SierraLeone and Nigeria. By August 13,2014,there have been 2 127 cases,1 145 died in West Africa. Nowadays, many people focus on EBHF in the world because further development of the epidemic situation. In this paper, the related research progress of EBHF and Ebola virus(EBOV) were reviewed.]]> 2017/12/25 16:02:35 TAN Chun-mei, LV Hui-yu, LV Yuan-cong 595true ［Abstract］　Sperm is a kind of inaccessible antigens that can lead to synthesize anti-sperm antibody potentially. The binding of anti-sperm antibody to sperm surface antigen may affect some biological processes, such as the formation of fertilized egg and embryo implantation, and thus result in immunological infertility. In recent years, sperm surface antigen and its epitopes combining with anti-sperm antibody related to immunoinfertility have become one of the major research objects in the research of anti-sperm antibody detection and contraceptive vaccines preparation. In this paper, we review briefly the screening and identification of sperm surface antigen as well as its epitopes related to immunoinfertility and the challenges that the research faces.]]> 2017/12/25 16:02:35 TAN Shu-hong, QIN Ying-jian, ZHANG Chao-hui, et al. 594true ［Abstract］　Caesarean scar pregnancy(CSP)is one of the rare ectopic pregnancy.With the increasing of caesarean section rates,the incidence of caesarean scar pregnancy tends to rise.The pathogenesis of caesarean scar pregnancy is unknown,diagnosis has no unified standard,and the misdiagnosis rate is high.Clinical treatment also remains controversial.This review focused on the research progress in diagnosis and treatment of caesarean scar pregnancy.]]> 2017/12/25 16:02:35 LI Jing-ling, HU Xiao-xia 593true ［Abstract］　microRNA（miRNA）are small non-coding RNAs of 18～25 nucleotides，which can negatively regulate the gene expression at post-transcriptional level by interacting with complementary sites in the 3′untranslated sequences of the target gene.Recent studies have identified that miRNAs are highly expressed in vasculature and heart，participate in the regulation of cardiac development, arrhythmia, hypertension, myocardial infarction, heart failure and other cardiovascular physiology and pathology process. Here is to make a review on the research progress regarding the roles of miRNAs in acute myocardial infarction.]]> 2017/12/25 16:02:35 GONG Guo-ping, WANG Hong 592true ［Abstract］　Diabetic foot(DF) is the main cause of non-traumatic amputation with a rising trend year by year. There are many inspection methods help to determine the amputation level,and how to choose one or several inspection methods to determine a suitable surgery amputation level is a question that clinical doctors must consider about. This paper reviews several inspection methods which is commonly used to determine the amputation level of DF patients and some influence factors.]]> 2017/12/25 16:02:35 YU Shao-lin, LI Hong-yu 591true ［Abstract］　Neck recurrence is a common type of recurrent nasopharyngeal carcinoma(NPC), and its diagnosis and re-treatment is an indispensable part of NPC treatment. It is of great significance to identify neck recurrence because it can affect the quality of life and survival of NPC patients. Here is to make a review of factors, diagnosis, treatment status and research progress of neck recurrence.]]> 2017/12/25 16:02:35 ZHANG Zheng, SI Yong-feng 590true ［Abstract］　Endometriosis（EMS） is one of the commonest gynecologic diseases with increasing incidence rate year by year. It causes dysmenorrheal, abnormal uterine bleeding, infertility and so on. These disease seriously affect women′s health and life quality. Many researches have been made about its mechanism, especially, the mechanism of NF-κBp65 in endometriosis. However, the mechanism of NF-κBp65 has not been fully elucidated and endometriosis is lack of effective treatment methods. Here we summarize the mechanisms of NF-κBp65 in endometriosis, which is helpful for promoting its research and application.]]> 2018/1/2 8:38:53 HUANG Xiao-feng, LI Wei-hong 589true ［Abstract］　The definition of target controlled infusion(TCI) is that of a computer-assisted intravenous administration of drugs for induction and maintenance of general anesthesia. Since few years, TCI -devices are available for using in the postoperative analgesia. The purpose of this review is to summarize recent studies about TCI and reveal its advantage in analgesia.]]> 2018/1/2 8:38:53 LI Yang, PENG Dan-hui, HUANG Bing,et al. 588true ［Abstract］　Vascular endothelial growth factor(VEGF) plays an important role in maintaining the existing blood vessels and promoting new vessels formation in tissue and organs. VEGF binds to its receptor on the endothelial cell surface leading to cellular biological function through activation cellular transduction pathways. Abnormal VEGF and VEGFRs expression have been observed in different types of cancers which results in the invasion of cancer cells to surrounding tissues and distant metastasis. Numerous reports showed that the expression of VEGF and VEGFRs in tissue and their levels in serum are associated with cancer development and metastasis, thus being a good marker in cancer treatment and clinical outcome. Serum VEGF and VEGFRs analysis is a simple, low cost, and noninvasive method in clinical practice, and the combination of the analysis of serum VEGF and VEGFRs with other cancer biomarkers may increase their diagnosis value.]]> 2018/1/2 8:38:53 LUO Yan-fang, HUANG Hua-yi 587true ［Abstract］　Gallbladder wall thickening of patients with liver cirrhosis was commonly observed by gray-scale ultrasound.Its characteristic of performance varies for individuals.The main reasons leading to gallbladder wall thickening of cirrhotic patients include portal hypertension,hypomagnesemia,inflammatory reaction,etc.However,the physiopathologic mechanism of different types of thickening is not clear in current research.In this review,the gallbladder wall thickening with cirrhosis was classified and the relationship between the performance and the physiopathologic mechanism was summarized.]]> 2018/1/2 8:38:53 SONG Ru-xin, TANG Bi-qiu, YANG Dong-hong, et al. 586true ［Abstract］　Laparoscopic techniques have evolved quickly in recent years, the technology in the treatment of pediatric inguinal hernia has been widely used, and has gradually been accepted by the majority of the parents and pediatric surgeons. On the basis of reviewing and analyzing the pertinent literature, the paper gives a review on the progress in terms of laparoscopic treatment for children inguinal hernia.]]> 2018/1/2 8:38:53 LIU Yang-hua，DENG Hong-qiang 585true ［Abstract］　Self-care is advocated as a method of improving prognosis of chronic disease such as chronic heart failure(CHF). The mortality, re-hospitalization rate and the cost of hospitalization could be reduced by self-care from the CHF patients. In this paper, we made a review about the self-care from strategy and promotion in the CHF patients.]]> 2018/1/2 8:38:53 QIU Xiao-qin，ZHANG Min，HUANG Xiao-juan，et al. 584true ［Abstract］　Angiostatin(AS) is thought to be one of the effective neovascularization inhibitors. Many researches have revealed its strong inhibit effect on tumor and ocular neovascularization. The research progress on the effect of AS on neovascularization is reviewed in the paper.]]> 2018/1/2 8:39:31 ZENG Jing, TAN Yi 583true ［Abstract］　Percutaneous lung biopsies(PLB) yield high diagnostic accuracy for lung lesions, especially peripheral lung nodules or masses, with micro-invasion. The most common complications include pneumothorax and hemorrhage. Air embolism, subcutaneous emphysema, pulmonary infection dissemination following biopsy, malignant seeding of needle tract are seldom. Most complications can resolve without treatment. The chest tube drainage for pneumothorax, blood transfusion for hemorrhage and hyperbaric oxygen therapy for the air embolism are needed when the complications are serious. The big size needle, smoking, long intrapulmonary path, number of needle passes and long puncture time are the risk factors for the complications.]]> 2018/1/2 8:39:31 FENG Guang-hong, QIN Zhi-qiang 582true ［Abstract］　Biotherapy is the 4th treatment modalities after surgery, radiotherapy and chemotherapy, and it was divided into two types-the cellular and the non-cellular. This paper reviews the progress on research and clinical application of biological treatment of nasopharyngeal carcinoma.]]> 2018/1/2 8:39:31 QIN Yang-da, SI Yong-feng 581true ［Abstract］　As the improvement of laparoscopic radical resecfion of rectal cancer, its application is more and more wide, and its surgical safety, feasibility and long-term efficacy and radical effect are gradually recognized. This paper reviews its research progress.]]> 2018/1/2 8:39:31 LAO Jing-mao, TAN Yi 580true ［Abstract］　At present，heart transplantation has become an effective therapy for patients with end-stage heart failure.This article reviews recent research about steady induction and maintaining of anesthesia，maintaining stable hemodynamics，the treatment of heart transplant patients with pulmonary hypertension, immunosuppression during perioperative period.]]> 2018/1/2 8:39:31 HUANG Xiao-Bin, YE Feng-Qing 579true ［Abstract］　Neonatal apnea is divided into primary apnea and secondary apnea. Premature is the main reason for primary apnea. Apnea of prematurity(AOP) is one of the main clinical problems in the neonatal intensive care unit. Standard clinical management of AOP includes prone positioning, methylxanthine therapy and nasal continuous positive airway pressure（NCPAP），other therapies, including nasal intermittent positive pressure ventilation （NIPPV），humidified high flow therapy via nasal cannula(HHFNC)，sensory stimulations, CO₂ inhalation ect, require further study.This review focuses on the AOP therapies.]]> 2018/1/2 9:44:23 LI Nian, TAN Yi 578true ［Abstract］　Radiation-induced brachial plexus injury(RIBPI) is a functional disorder of the brachial plexus(BP), caused by higher total radiation dose or higher single dose to the BP during radiation therapy(RT). The etiology involved in the development of RIBPI includes RT, combined treatment modalities, and individual susceptibility. Its latent may vary largely, from a few months to several years. Initial symptom may be subjective paresthesia or neuropathic pain in the upper extremities. Subsequently, the patients may suffer from hypesthesia in the upper extremities, weakness, or even paralysis. The diagnosis of RIBPI is based on history of RT, interval with no symptom, clinical manifestation, physical exam, magnetic resonance imaging (MRI), and electromyogram. Differential diagnosis should exclude metastasis from malignant disease or radiation-induced second malignance. It is believed that the RIBPI is a progressive process which may eventually result in devastating functional consequences, and no effective modality is available to treat this disease so far. Medication and surgery only play a palliative role in this disease. Therefore, methods for preventing BP injury before its onset appear particularly crucial.]]> 2018/1/2 9:44:23 LIU Xu, LU He-ming 577true ［Abstract］　The main features of multiple myeloma bone disease(MBD) are hyperactivity of systemic bone destruction and inhibition of new bone formation.Its clinical manifestations include pain, osteoporosis, pathologic fractures and associated nerve compression symptoms etc. MBD is one of the most common complications of multiple myeloma(MM). Its occurrence is occult with higher misdiagnosis rate and patients′quality of life and prognosis are poor. In this article， its pathogenesis,diagnosis and treatment are reviewed, in order to provide reference for clinical treatment of MBD.]]> 2018/1/2 9:44:23 ZHAO Ning,YAN Dong-xue 576true ［Abstract］　B-type natriuretic peptide(BNP) is a kind of polypeptide neuroendocrine hormone. It has been wildly expressed in human heart, brain, lung and other important tissues and organs. BNP and N-terminal pro-B-type natriuretic peptide(NT-proBNP) could be used as an important biological markers which play important roles in the diagnosis, treatment, risk stratification and prognosis of patients in cardiovascular disease. This paper reviews new research advance and new recognition on BNP and NT-proBNP, and its features of molecular biology, Laboratory detection technology, used value and clinical application.]]> 2018/1/2 9:44:23 HU He-hua, LI Jiang-e, TAN Yi 575true ［Abstract］　Pelvic floor muscle training(PFMT) refers to the initiative exercise of pelvic floor muscles which mainly consist of pubococcygeal muscles. PEMT can improve urethral resistance, enhance the ability to control the urine. The studies found that childbirth and gestation can cause the damage of pelvic nerve and muscle, and vaginal delivery may affect the function of the pudendal nerve and its branches. PFMT during gestation period can enhance maternal pelvic blood circulation, improve pelvic floor muscle tension, reduce the compression of gestation uterine on veins of lower extremity，reduce the accumulation of fat in the pelvis, avoid the occurrence of stress urinary incontinence，postpartum sexual dysfunction and other diseases. This paper mainly reviews the research progress of PFMT in gestation period and early postpartum period.]]> 2018/1/2 9:44:23 XIE Di, TAN Yi 574true ［Abstract］　Matrix metalloproteinases(MMPs) are a group of zinc dependent extracellular protease family. MMPs share a common domain structure with different substrate specificity, different cellular origin and inducibility. The major function of MMPs is to degrade and remodel the extracellular components. There are more than 20 MMPs members have been confirmed so far. The MMPs can be categorized into gelatinase(MMP-2 and MMP-9), interstitial collagenase(MMP-1, MMP-8, and MMP-13), and other types based on their substrate specificity. Studies have demonstrated that the activity of MMPs is associated with cancer cell proliferation, migration, and differentiation. The degradation of extracellular matrix by MMPs results in the invasion, migration, and metastasis of cancer cells. Over expression of MMPs have been found in various types of tumors. Studies also showed that serum MMPs level is correlated with their tissue expression and associated with cancer progression, prognosis, and response to chemotherapy. Serum or plasma MMPs analysis is a simple, fast with low cost method, thus, it is very helpful in cancer diagnosis and prognosis prediction.]]> 2018/1/2 9:44:48 XIA Li-li, Huang Hua-yi 573true ［Abstract］　The antithrombotic treatment advance on non-ST-segment elevation acute coronary syndrome in recent several years was reviewed in this paper. There are two kinds of antithrombotic drugs, antiplatelet and anticoagulant drugs. The antiplatelet agents include aspirin, adenosine monophosphate(ADP) receptor antagonist and platelet membrane glycoprotein(GPⅡb/Ⅲa) antibody antagonist. The anticoagulant drugs consist of heparin, low molecular weight heparin, anti factor Xa inhibitors and the direct thrombin inhibitor etc.]]> 2018/1/2 9:44:48 WEI Xiao, YIN Rui-xing 572true ［Abstract］　Hospital infection， which neither exists on admission nor in the incubation period, refers to an infection acquired in hospital, including those which is obtained in hospital while its symptoms appear outside the hospital. Neonate department is a high-risk hospital infection area.Because most of neonates organs are immature and their immune function and disease resistance are lower, they are particularly susceptible to hospital infection. Therefore, analyzing the risk factor and providing the strategy for the prevention and control of hospital infection in neonates may be helpful to reduce the hospital infection rate of neonates.]]> 2018/1/2 9:44:48 FENG Jian-hua,CHEN Qi-tang,TAN Yi 571true ［Abstract］　Unhealthy lifestyle is one of significant risk factors of coronary heart disease and can be changed by health education.However,there are several problems in current health education in patients with coronary heart disease,including low awareness rate and poor compliance. This paper reviews the role of health education and its application in patients with coronary heart disease, thus to improve their knowledge about it and finally delay the progress of the coronary heart disease.]]> 2018/1/2 9:44:48 JIA Yun-li, LI Jin-lian, JIN Xian-ping 570true ［Abstract］　Studies have shown that the kainate receptors(KARs) plays a very important role in neurodegenerative diseases.The excitatory neurotransmitters can cause up-regulation of KARs expression and neuronal cell death through excessive activation of KARs.Studying the mechanism of action of KARs can provide treatment target for neurodegenerative diseases.]]> 2018/1/8 8:50:20 YUAN Lei, GONG Ji-qin, ZHANG Hai-xia, et al. 569true ［Abstract］　The chemoradiotherapy for medium-term and advanced cervical cancer has better efficacy than the pure radiotherapy to improve overall survival rate and progression free survival rate,it can reduce the recurrence rate and improve prognosis. Chemoradiotherapy is not a simple radiotherapy combined with chemotherapy and chemotherapy can not only kill cancer cells and tumor subclinical lesions, also increase sensitivity of cancer cells to radiotherapy. Chemoradiotherapy mechanism may be: chemotherapy could inhibit tumor cells′ radiation damage repair, reduce the proportion of hypoxic cells which is not sensitive to radiotherapy and promote the tumor cells entering into the radiation sensitive cell cycle synchronously. Most think that the effect of concurrent chemoradiotherapy program based on cisplatin is better, concurrent chemoradiotherapy has more side effects than alone radiotherapy,and its concrete usage is still in groping stage.]]> 2018/1/8 8:50:20 GAN Zu-huan，GAN Lang-ge,TAN Yi 568true ［Abstract］　Congenital cleft lip and palate will cause abnormal voice function of patients.The research of detection and analysis method of voice anomaly helps the correction of voice function. This article will review the recent detection and analysis methods of voice anomaly in patients with cleft lip and palate.]]> 2018/1/8 8:50:20 QIN Shi-yu, LI Dong-shuang, SUN Jin-hu 567true ［Abstract］　Sleeping posture can have a certain effect on the upper airway obstruction, improve nocturnal ventilation in the patients with obstructive sleep apnea syndrome(OSAS).This article reviews the recent progress in clinical research on the effect of lateral sleep in the treatment of OSAS.]]> 2018/1/8 8:50:20 LEI Zhi-jian,TAN Yi 566true ［Abstract］　Central venous oxygen saturation(ScvO₂) in adult ICU is commonly used to monitor the critically ill patients and guide resuscitation, and its application in pediatric critical care monitoring in recent years is gradually accepted, especially in the resuscitation of septic shock, severe respiratory tract infection, and estimation of the prognosis of critically ill, and in other fields,it can be used for the early detection of disease change and guiding treatment decisions. In this paper, the progress of clinical application of ScvO₂ monitoring in pediatrics was reviewed.]]> 2018/1/8 8:50:20 LU Ji-fang,WU Shu-yue 565true ［Abstract］　The incidence of cervical cancer ranks first in female genital tract malignancies in China.Surgical treatment is still the main therapy of the disease.The transition of criteria for evaluating surgical treatment effect has greatly profited from using many new technologies and the development and application of surgical instruments,especially the application of Ultracision-harmonic scalpel（UHS) and Ligasure vessel sealing system.This paper reviews the application of UHS and Ligasure vessel sealing system in cervical cancer surgery.]]> 2018/1/8 8:50:54 HUANG Wei-long，ZHAO Ren-feng 564true ［Abstract］　MicroRNA（miRNA）are a class of endogenous and small molecule noncoding single-stranded RNAs with highly conserved sequences among different specis,about 18～22 nucleotides(nt),and have tissue specificity and time sequences specificity. miRNA can regulate the translation or expression of target miRNA at the post-transcriptional level and play important roles in the biological precesses of cell growth, cell proliferation, metabolism, apoptosis and so on.A number of studies have demeonstrated that miRNA have a close relationship with pathogenesis and development of bronchial asthma(asthma)which had been found to express abnormally in asthma for some miRNA such as let-7 family, miR-125 family, miR-26 family, miR-155, miR-21, miR-133a, miR-26a, miR-221, etc. Here is to discuss the role of miRNA in foundation of pathology and physiology of asthma and the pathogenesis mainly characterized by persistent airway inflammation，airway hyperresponsiveness and airway remodeling.]]> 2018/1/8 8:50:54 PENG Qiu-xiang, TAN Yi 563true ［Abstract］　Sclerotherapy have been used widely in the treatment of benign ovarian cysts with its advantages of minimal invasiveness,safety, effectiveness,hardening agent play a crucial role in the sclerotherapy.As classical hardening agent,anhydrous ethanol had many problems in the clinical practice.Lauromacrogol is a new medicine, which having obtained drug approval numbers in China,it may become an optimal substitute to anhydrous ethanol in sclerotherapy.It has wide application value and development prospect.In this article, the application of hardening agent in benign ovarian cysts was reviewed.]]> 2018/1/8 8:50:54 YI Xiao-yu, YU Lei 562true ［Abstract］　Nicotinamide phosphoribosyl transferase(Nampt) is a key limiting enzyme of nicotinamide adenine dinucleotide(NAD) biosynthesis.Nampt adjusts the regulation of Sirt1 activity by adjusting NAD biosynthesis and thus participates in cell differentiation, proliferation and apoptosis and other processes. In this paper the research progress on relationship between Nampt and diabetes-associated vascular diseases was reviewed.]]> 2018/1/8 8:50:54 HU Ya-jun，GUO Hui-jia，ZHANG Li-ming,et al. 561true ［Abstract］　Polycystic ovary syndrome(PCOS) is characterized by hyperandrogenism,ovulatory dysfunction and polycystic ovary.The exact pathogenesis of PCOS remains elusive,present researches mainly focus on the field of genetic polymorphism.Genetic researches showed that the genes which were correlated with insulin effects, synthesis and metabolism of steroid hormone, dysfunction of gonadal hormone, folliculogenesis,chronic inflammatory factors, might contributed to PCOS pathogenesis.]]> 2018/1/8 8:50:54 LIU Min,WANG Lin 560true ［Abstract］　Preterm labor(PL) is one of common complications of pregnancy. The occurrence rate is high, and is the major cause of death for perinatal infants. Therefore, improving the level of prevention and treatment of PL have important significance for reducing the morbidity and mortality of perinatal infants. In this paper,a brief review of clinical research progress of PL with an emphasis on prevention and treatment of PL was performed.]]> 2018/1/15 8:41:56 ZHOU Xiao-yi, TAN Yi 559true ［Abstract］　With the development of magnetic resonance imaging (MRI) and the cognition of Modic changes in the vertebral endplate and sub-endplate bone, lumbago originating from endplate is more and more paid attention clinically. The present study suggests that lumbago originating from endplate is closely related to injury of endplate degeneration, but the pain mechanism is not fully clear. Conservative treatment is still the main means. Surgical treatment is indispensable. All kinds of new methods and new technology is also gradually developed. Clinical curative effect still needs further study.]]> 2018/1/15 8:41:56 TONG Yan-ge,LI Xian-lin,TAN Yi 558true ［Abstract］　This paper introduced the self-management present situation and the influence factors of self-management behavior and the strategies of intervention for maintenance hemodialysis(MHD) patients, to improve the quality of nursing and the life of patients.]]> 2018/1/15 8:41:56 LV Hai-lian,WU Chao-qing, TANG Ye-ying, et al. 557true ［Abstract］　Postherpetic neuralgia( PHN) is the most common complication of herpes zoster, the disease is characterized by chronic intractable pain, its pathogenesis remains unclear. There are many therapeutic methods for PHN clinically, but many patients′ pain have not been adequately relieved after treatment, or they can not tolerate the adverse drug reaction. Hyperbaric oxygen therapy is a new treatment method emerging in recent years, which has the unique clinical efficacy and advantage in treatment of the disease. This paper reviews the current research situation of hyperbaric oxygen therapy and pathogenesis of PHN in treatment of the disease in recent years.]]> 2018/1/15 8:41:56 HUANG Jian-ping，XU Li-min 556true ［Abstract］　Surface plasmon resonance(SPR) technology as a new technology is successfully applied in prenatal diagnosis. In this paper， the principle of the new technology and its application in prenatal diagnosis were reviewed briefly.]]> 2018/1/15 8:42:20 HUANG Li，WANG Shi-kai，HE Bin 555true ［Abstract］　This paper described the shortcomings of transurethral resection of bladder tumor (TURBT) , analyzed the influence of the cutting method, cutting equipment, anesthesia method, infusion, operator′s operation level on TURBT,and pointed out the important points of clinical application.]]> 2018/1/15 8:42:20 RONG Zu-yi, LI Wei, MO mo,et al. 554true ［Abstract］　Recurrent respiratory tract infections(RRTIs)are common clinical diseases in peadiatrics with complex pathogeny. Etiology of RRTIS involves multiple factors, mainly including immune hypofunction and dysfunction, infection of pathogenic microorganism, the bacterial drug resistance induced by unreasonable application of antibiotics, deficiency of trace elements, the variation of particle composition of air, etc. These factors result in the body getting sickness often more easily, and disease recurring repeatedly, by acting on the body solely, or stimulating the body by combined interaction, or long term subliminal irritation of the respiratory tract. By investigating its reason, RRTIS can be prevented and treated preferably with the combination of Chinese and western therapy. This paper briefly reviews the research advances on etiology, prevention and treatment of RRTIS in children.]]> 2018/1/15 8:42:20 CHEN Hong-bing, TAN Yi 553true ［Abstract］　Alzheimer disease （AD）is the main cause that affects the quality of life in elderly at present, and the curative effect on AD is not very good. Therefore, it′s especially important to diagnose the mild cognitive impairment(MCI) that emerges in the early stage of AD. As the carotid artery stenosis has close relation with MCI, the research progress of the relations between carotid artery stenosis and MCI is reviewed in the paper.]]> 2018/1/15 8:42:20 WU Yong-jun, ZHONG Wei-zhang 552true ［Abstract］　Motor imagery(MI) combined with physiotherapy can offer functional benefits after stroke. Due to the simple, MI can fully mobilize the patients to actively participate in rehabilitation training, and is gradually applied to clinical practice. This paper briefly reviewed the brain mechanisms of motor imagery and its application in motor rehabilitation in patients with stroke.]]> 2018/1/15 8:42:20 CAO Wan, CHEN Qi-bo 551true ［Abstract］　Proteomics is a tool of expounding complex mechanism of life,and the protein mass spectrometry reveals the categories and characters of the proteins involved in life activities. Applying proteomics to studying sperm protein mass spectrum can find the specific protein markers of disease such as infertility etc, explore the pathogenesis,get the treatment methods, and has important significance for fertility regulation and sterility treatment. This paper reviewed the research progress on sperm protein mass spectrometry.]]> 2017/12/18 8:27:36 ZHAO Qi, WANG Xiao-ping 550true ［Abstract］　The pathogenesis of Alzheimer′s disease(AD) is complex. Besides, the loss of neurons cannot be regenerated. Although there is no specific treatment, but the early diagnosis and early treatment is still very important for delaying the rapid decline in the quality of daily life of patients. The drugs of prevention and treatment for AD include first-line drugs，chinese drugs preparation，the drugs that are still in the research phase and other drugs. In this paper，the current studies on the drugs of prevention and treatment for AD were reviewed.]]> 2017/12/18 8:27:36 TENG Xiao-ming, LIN Xin-jing 549true ［Abstract］　Flow cytometry（FCM) is the most convenient, rapid, accurate and high specificity in all metheod for monitoring the minimal residual disease（MRD）in leukemia in clinical work. In this paper, the application of FCM in the monitor MRD in leukemia after treatment was briefly reviewed.]]> 2017/12/18 8:27:36 YANG Wen-jie, TAN Yi 548true ［Abstract］　Uterine myomas are the most common benign tumors of female genital, they occur commonly in the child-bearing age,and seriously affect the physical and montal health of women of childbearing age.Recently,more and more attention is paid to treatment of uterine myomas.Here a review is made on the reasearch progress of treatment of uterine myomas.]]> 2017/12/18 8:27:36 WEI Hai-tang, LIU Ni-ping, CHEN Chang-yi 547true ［Abstract］　Rectal cancer is a common disease in general surgery and its morbidity and mortality is high. ranking at the top three positions among malignancies. In recent years, with the development of clinical research and diagnostic techniques the studies found between rectal cancer within 12cm from the anus and supper colorectal cancer there is significant difference in anatomy, disease progress, diagnosis, treatment means and efficacy.Rectal cancer is redefined as the traditional mid-low rectal cancer, which is rectal cancer within 12cm from anus. This paper summarized the research process on change of rectal cancer diagnosis and treatment model.]]> 2017/12/18 8:27:36 LONG Ren-ping, LIU He 546true ［Abstract］　Malignant pleural effusion which carries a poor prognosis is frequently observed in malignant pleural metastasis or malignant pleural mesothelioma. The factors that recruit tumor cells into pleural cavity are involved in both tumor cells characteristics and hosts. In malignant pleural effusion lymphocytes are dominant, and regulatory T cells are upregulated. Regulatory T cell(Treg) is a unique CD4+CD25+ T cell population of “professional” regulatory/suppressor T cells that actively and dominantly prevent both the activation and the function of autoactive T cells that have escaped other mechanisms of tolerance. This paper reviewed the research progress in regulatory T cells and its role in the pathogenesis of malignant pleural effusion.]]> 2017/12/19 8:06:01 QIN Xue-jun, WEI Bi-miao, TAN Yi 545true ［Abstract］　Neonatal respiratory distress syndrome (NRDS) is a critical illness that caused early neonatal death because the lack of pulmonary surfactant(PS).Remarkable progress in the treatment of NRDS has been made in recent years. This paper summarized the progress in treatment of NRDS with PS replacement therapy, oxygen therapy and extracorporeal membrane oxygenation.]]> 2017/12/19 8:06:01 HUANG Guo-sheng, TAN Yi 544true ［Abstract］　On the basis of consulting the domestic literatures about Kangfuxin-liquid in recent years, this paper summarizes the curative effects of it in the obstetrics and gynecology disease，such as cervical erosion, vaginitis, cervical intraepithelial neoplasia，cervical cancer concurrent chemoradiation disease ，in order to provide references for clinicians.]]> 2017/12/19 8:06:01 LI Xue，WEI Li-ying，ZHAO Ren-feng 543true ［Abstract］　Sepsis that caused by infection is systemic inflammatory response syndrome, its morbidity and mortality are very high.At present sepsis is still one of the main causes of death in patients who was critically ill. The early diagnosis of sepsis is particularly important. This paper reviews the research progress on procalcitonin, CD-64, Toll-like receptor 4 and interleukin-6 in the diagnosing sepsis.]]> 2017/12/19 8:06:01 WANG Yan-shuang, HE Ya-jun 542true ［Abstract］　Severe traumatic brain injury(sTBI) is a common emergency neurosurgical disease, accounting for about 20% of traumatic brain injury. During the acute phase,the patients′ conditions change qwickly, with much more complications and difficulty to treat and care. Also, it has high rate of disability and mortality, and the mortality rate is about 30%. The quality of nursing care will directly affect the safety of the patients. In this paper, a review is made on disease observation, intracranial pressure monitoring, cerebral protection, enteral nutrition, sedation, treatment of dehydration and stress hyperglycemia in patients with sTBI in acut phase.]]> 2017/12/19 8:06:01 LI Yan, HUANG Li-yan 541true ［Abstract］　This paper reviews the progress on research of bibliometrics of medical scientific papers published in China from 2003 to 2013.]]> 2017/12/25 16:01:51 HUANG Xiao-hong, HUANG Wen-sheng, WEI Hui-de, et al. 540true ［Abstract］　Great progress has been made in the diagnosis and treatment of peritoneal carcinomatosis(PC) from colorectal cancer(CRC). Traditionally, PC from CRC had been considered a form of systemic metastasis portending a terminal state of CRC for which only palliative surgery and/or systemic chemotherapy was recommended.However, patients with metastasis localized to the peritoneum have been shown to be candidates for metastasectomy with improved clinical outcomes. Complete cytoreduction in combination with HIPEC for peritoneal surface disease has been demonstrated to grealtly improve the survival outcomes. This review will examine recent evidence pertaining to the evolving surgical oncology paradigm for management of colorectal peritoneal carcinomatosis.]]> 2017/12/25 16:01:51 WEI Shi-zhuang, FENG Guan-rong 539true ［Abstract］　Vitamin D(VD) is a group of steroid compounds, which plays an important role in a variety of biological functions including promoting the intestinal absorption of calcium and phosphorus, building and maintaining the bone hardness. Recently studies have found that VD exerts cell proliferation inhibition, cell differentiation and apoptosis induction, and chemoprevention properties. Studies showed that there is a clear association between serum VD level and breast cancer. However, in other types of cancer, study results on the relationship between serum VD and cancers are still controversy, inconclusive or contradictory. This article discuss and summarize the relationship between serum VD concentration and cancer and its detection methods.]]> 2017/12/25 16:01:51 JIANG Lie-jun, HUANG Hua-yi 538true ［Abstract］　In recent decades，PET/CT imaging technique became an increasingly using tool by clinicians，and is playing a more and more crucial role in the diagnosis and assessment of patients with malignant pleural mesothelioma(MPM). This review article is about recent research of PET/CT for diagnosing MPM.]]> 2017/12/25 16:01:51 LUO Ling, LIU Hang 537true ［Abstract］　Norcantharidin(NCTD), an important derivative of cantharidin, has distinctive therapeutic effects on cancers and some incurable diseases. Norcantharidin has low toxicity and clear pharmacological effects without bone marrow suppression and other adverse reactions. Recently, some studies showed that NCTD could not only reduce urinary protein of rats with renal diseases, but also protect renal tubulointerstitial fibrosis by multiple mechanisms. NCTD may have a good value of application on immune-related nephropathy and renal interstitial fibrosis prevention. The pharmacological mechanism of NCTD and its potential treatment of renal diseases are reviewed in this paper.]]> 2017/12/4 8:38:51 YE Kun, ZHENG Ya-li, PENG Xiao-mei 536true ［Abstract］　The knee osteoarthritis(KOA) is one of the difficult problems in the current clinical treatment. Although there are a lot of methods for the treatment of KOA, each method has its applicable scopes, advantages and disadvantages. In addition, there is no any kind of radical therapy that can reverse the disease. So, comparing and analysing the characteristics and the feasibility of different treatment methods can not only effectively provide some references and guidances for clinical research,but also properly help clinicians find the most suitable therapy for different patients with KOA.]]> 2017/12/4 8:38:51 XI Li-cheng, LI Hong-yu 535true ［Abstract］　At present, the highly active antiretroviral drugs are the most effective therapy to treat and control HIV/AIDS. Since these medications were used for AIDS treatment, the mortality has reduced greatly and the quality of life of AIDS patients has improved. It is the landmark in the history of AIDS treatment. In this paper, we review the progress of the highly active antiretroviral drugs in the application of AIDS treatment.]]> 2017/12/4 8:38:51 LV Ri-ying, LI Guo-jian 534true ［Abstract］　Patent foramen ovale(PFO) is the most common form of right-to-left shunt(RLS). In recent years, contrast transcranial Doppler ultrasonography has become an important means of detecting RLS of PFO and assessing residual shunt of PFO. This review is about the recent research of contrast transcranial Doppler ultrasonography in detecting RLS of PFO.]]> 2017/12/4 8:38:51 LI Yao-xuan, DONG Yan-ling 533true ［Abstract］　Osteoporosis(OP) is a complex multifactorial disease which is decreasing in bone strength and increasing the risk of facture. Bone strength includes two sides of skeleton, which are bone mineral density（BMD） and bone quality. As the serious OP consequences, skeleton may be fractured when it is hit by the trauma, which increases the rate of the elderly invalidism and fatality. BMD is the most excellent index, which may be used for diagnosing and predicting brittle fracture, detecting natural progression and drug intervention evaluation. The facture is related to low BMD and it may increase the risk of frature if other risk factors exists.Vitamin D receptor（VDR） gene is considered one of candidate genes in the bone mass regulation. The relationship of OP and VDR gene polymorphism has various viewpionts in the researches of different population. We review the relationship between VDR gene polymorphism and OP in this paper.]]> 2017/12/4 8:38:51 LI Fu-lin, HUANG Yu, YIN Dong 532true ［Abstract］　In recent years, with the development of material science and percutaneous intervention, intracranial stent angioplasty is applied to prevent and treat ischemic cerebrovascular disease, which has become a hot spot of clinical researches. It is a new method for treating patients with intracranial atherosclerotic stenosis. Its minimally invasive characteristic has been recognized and accepted by more and more patients, however the effectiveness and security of intracranial stent angioplasty have got more and more attention. The evolution of intracranial stent angioplasty, the selection of cases and the development of preventing complications are reviewed in this paper.]]> 2017/12/4 8:40:13 QIN Zhu-gui, ZHONG Wei-zhang 531true ［Abstract］　In order to investigate and guide the treatment of severe sepsis and sepsis shock effectively, a lot of researches have been done worldwide recently. Blood lactate clearance rate is considered to be an appropriate indicator. This paper briefly introduces the research progress of the application of lactate clearance rate in sepsis.]]> 2017/12/4 8:40:13 LIU Jian, LI Ning 530true ［Abstract］　Bone non-union is a common complication of fracture, especially with the various industrial injuries, traffic accidents, and high energy injuries, more and more complex fracture accidents, and the risk of bone non-union have greatly increased.For decades, with the popularization of the various new internal and external fixed materials, microsurgical technique and the innovation of bone graft material, especially application of the molecular biology techniques,breakthrough progress has been made in the treatment of bone non-union.This paper summarizes the treatment of bone non-union,which combines with the related literatures at home and abroad in recent years.]]> 2017/12/4 8:40:13 ZHAO Zi-xing, LI Hong-yu 529true ［Abstract］　In the patients with hypertensive intracerebral hemorrhage(HICH), intracranial hematoma secondary cerebral edema and secondary cerebral vasospasm pathological physiological change is an important factor leading to a bad prognosis.There is still lack of clinical indicators in the prognosis of the disease. TRAIL was discovered after TNF had been discovered. TRAIL is capable of inducing cell apoptosis. TRAIL is widely expressed in various tissues and cells and is connected with the formation process of HICH in a certain way, however, the relationship between TRAIL and its receptors with the pathological physiology changes in the HICH is still unclear.This paper introduces the recent research progress of TRAIL and its receptors in the peripheral blood of HICH.]]> 2017/12/4 8:40:13 ZHANG Yi, JIANG Guang-yuan 528true ［Abstract］　MicroRNA(miRNA) is a kind of regulatory gene with an endogeous small non-coding RNA of 18～22 nucleotides in length and plays an important role in biological process, which participates in regulating expression at post-transcriptional level. Current studies indicate that changes of miRNA expression levels are closely related to the formation of arrhythmia, for example, miR-1, miR-133, miR-328, miR-208, miR-21 and miR-15 can lead to arrhythmia through dysfunctions and abnormal expressions in cell membrane ion channels. Intervene and regulation expression levels of miRNAs may become a novel diagnosis therapeutic target for arrhythmia.]]> 2017/12/4 8:40:13 ZENG Xian- you, TAN Yi 527true ［Abstract］　The three major radiation resistance mechanisms are intrinsic radiosensitivity, tumor cell proliferation and hypoxia. The phosphatidy-linositol-3-kinase(PI3-K)/protein kinase B(AKT) pathway is one of the survival pathways of tumor cells. Activation of this pathway is closely related to radiation resistance. This review focuses on the PI3K/AKT signal pathway and radiation resistance mechanisms.]]> 2017/12/4 8:40:13 QIN Jian, LU He-ming, CHEN Jia-xin 526true ［Abstract］　Collateral circulation makes a big difference in the development of cerebral ischemic stroke（CIS）. Adequate collateral flow has been demonstrated to be related with a good outcome in 90 days after stroke. When a clinical decision is made in the treatment of CIS, the status of collateral circulation should be taken into consideration seriously. We review the relationship between collateral and CIS in this paper.]]> 2017/12/4 16:23:24 LIAO Cui-fang, ZHONG Wei-zhang 525true ［Abstract］　As the primary insomnia with onset in old age, senile insomnia is a common disease in the elderly. Alzheimer′s disease(AD), the most common cause of dementia, is a kind of neurodegenerative disease. Recent studies have shown that the insomnia is associated with cognitive dysfunction, and the incidence of dementia in elderly patients with insomnia markedly increased. And, mild cognitive impairment(MCI) may be an early sign of dementia, and is the key stage of the prevention and treatment of AD. Given the occult onset of MCI and significantly higher risk of dementia, early identification of risk factors, early diagnosis and effective preventive intervention of MCI have important clinical significances. The purpose of this paper is to summarize the relationship between insomnia and cognitive function in the elderly, and to provide a new research idea for the early prevention and treatment of AD.]]> 2017/12/4 16:23:24 ZHONG Liang, LIU Li, HE Rong-xin, et al. 524true ［Abstract］　Hysteroscopy has been widely used in clinical obstetrics and gynecology because of some advantages including direct-viewing, mini-invasive, less bleeding and rapid recovery after operation. This paper summarizes the progress of the hysteroscopic treatment for uterine body diseases including myoma of uterus, endometrial benign lesions, intrauterine adhesions, uterine malformation and intrauterine foreign body.]]> 2017/12/4 16:23:24 ZHAO Fang-fang, JIANG Xiao-li 523true ［Abstract］　Functional gastrointestinal disorders(FGIDs) are a group of common digestive diseases. Concomitant psychological disorders, such as anxiety, depression and somatization are common in FGIDs patients. These psychological disorders influence the patients′ gastrointestinal symptoms and their health-related quality of life in different degrees. In this paper, we review the epidemiology of psychological co-morbidity in FGIDs, describe the impact of these psychological disorders on gastrointestinal symptoms and the quality of life in FGIDs patients and evaluate the effects of psychotropic treatment on FGIDs.]]> 2017/12/4 16:23:24 ZUO Guo-wen, LIANG Lie-xin 522true ［Abstract］　Selecting a bone filling material is necessary to fully meet the needs of endovascular graft bone defects, and to reduce the periosteum and bone tissue injury stimulus. Traditional autologous and allogeneic bone have better clinical efficacy and some clinical limitations. With technological innovation, more and more types of bone filling materials are applied to the bone tumor defects. Xenograft bone, biological ceramics, bone cement, polymers and collagen are all bone filling materials. Different bone filler materials have different advantages and disadvantages. In order to understand the various bone filling materials better, we review the advances in bone filling materials selected after bone tumor curettage in this paper.]]> 2017/12/4 16:23:24 HUANG Guo-fu, SUN Ke 521true ［Abstract］　Tendon injury is one of the most common sports injuries. In recent years, the incidence of tendon injury tends to rise with the popularization and development of sports. How to improve the therapeutic effect of tendon injury is always a difficult problem in clinical work and is the research focus of scholars at home and abroad. We review the research progress in the treatment methods of tendon injury in this paper.]]> 2017/12/4 16:23:24 LIU Bo-yu, LI Hong-yu 520true ［Abstract］　The imaging technique of multi-slice spiral CT(MSCT) examination for gastric cancer is becoming more and more mature. Multi-phase enhanced scan with MPR post processing technique can fully display the stomach wall of multilayer structure and show the abnormal changes of gastric wall structure, which is useful in diagnosing gastric cancer. Presently, the preoperative TNM staging evaluation through the observation of gastric cancer invasion depth of gastric wall, lymph node metastasis and distant metastasis of gastric cancer, has become a popular clinical research topic. Applying MSCT for preoperative diagnosis of gastric cancer is reviewed in this paper.]]> 2017/12/4 16:23:24 DENG Lin, FANG Hua-sheng 519true ［Abstract］　Total hip arthroplasty(THA) is an effective method for curing hip joint diseases and rebuilding joint function which gets a great success in clinic. Because of the biological inertness of ceramic materials, they can effectively decrease the complications of prosthetic loosening and subsidence caused by wearing of joint interface in total hip arthroplasty, which makes the ceramics joint prosthesis become the indispensable mainstream material. However, hip squeaking and the prosthesis fragmentation occurring after ceramic-on-ceramic(COC) total hip arthroplasty have become the focus in the field of joint surgery. The progress, advantages and disadvantages of the application of COC materials in total hip arthroplasty are reviewed in this paper.]]> 2017/12/4 16:23:24 ZHENG Dian-tao,YIN Dong 518true ［Abstract］　Prostate cancer(PCa) is a common malignant disease in old people, a serious threat to the health of men.In recent years, the world health organization′s statistical data shows that PCa has a higher incidence than lung cancer and become the most common malignant tumor in men in the world. The early diagnosis is important for the prognosis of patients. The clinical diagnosis methods of prostate disease include digital rectal examination(DRE), serum prostate specific antigen(PSA), and the imaging examination methods, which include the transabdominal ultrasound(TAUS), transrectal ultrasound(TRUS), ultrasound imaging, real-time ultrasound elasticity imaging, transrectal ultrasound guided 6 + X points prostate biopsy(TRUPB), and other inspection methods. In this paper, the application progress on PSA and ultrasound techniques in the diagnosis of PCa is briefly reviewed.]]> 2017/12/6 8:06:37 LIU Tai-le, WANG Xiao-yan 517true ［Abstract］　Cerebral embolism is a serious condition, resulting in a large infarct size and progressing rapidly in a short time. Embolism causes a sudden interruption of blood flow which leads to sufficient collateral circulation in the brain tissues, and dead brain cells. Cerebral embolism leads to massive cerebral infarction, high morbidity and high mortality. The best treatment of cerebral embolism is to make occlusive cerebral artery recanalization at the early stage. It is feasible to carry out intravenous thrombolytic therapy within 3 h of the onset of cardiogenic cerebral embolism in patients. The lower the score of national institutes of health stroke scale(NIHSS), the better the thrombolytic effect and the lower the probability of occurrence of cerebral hemorrhage. If the onset time >3 h or NIHSS score >20 points, thrombolysis should be cautious, because these situations are prone to cerebral hemorrhage. Thrombolysis should be performed strictly according to its indications and contraindications. It is necessary to use SITS SICH risk score and multimodal magnetic resonance imaging（T1, T2, DWI, PWI, SWI） to assess the risks of cerebral hemorrhage before doing thrombolysis. In addition, reducing blood pressure variability may reduce the risk factors of intracerebral hemorrhage after thrombolysis.]]> 2017/12/6 8:06:37 LAO Quan-kun, WANG Da-cheng 516true ［Abstract］　Care service is a comprehensive measure for post-abortion care, which uses modern contraception to educate abortion women and their families, and makes them master effective contraceptive knowledge to avoid accidental pregnancy and reduces repeating abortion rate. In China, some hospitals provide post-abortion care for the outpatients. Due to the influence of many factors, so far the quality of post-abortion care is not satisfactory and thus plays a key role in the quality control of the post-abortion care services. We summarise the current research of post-abortion care services in this paper.]]> 2017/12/6 8:06:37 CHEN Mei-fang, ZHAO Ren-feng 515true ［Abstract］　Congenital clubfoot is one of the most common limb deformities of children, and its causes are unknown yet presently. In China, such methods as Ponseti therapy, improved Ponseti therapy, operative treatment, and traditional Chinese medicine, etc. have been applied in the treatment of the congenital clubfoot, and the curative effect is quite good. This article makes a summary on this respect, hoping to offer reference for the clinical workers.]]> 2017/12/6 8:06:37 ZHANG Ming-wu, TAN Yi 514true ［Abstract］　With the development of minimally invasive techniques,ultrasound guided radiofrequency ablation of liver cancer has become one of the newest effective methods in the treatment of primary liver cancer,and the application is becoming more and more perfect.Selecting a safe,economic,effective and appropriate anesthesia method is crucial to its development.In recent years, the topic related to anesthesia methods in ultrasound guided radiofrequency ablation of liver cancer is a research hotspot in anesthesiology.This article is a brief overview about the latest research results in the field.]]> 2017/12/6 8:06:37 RAN Xue-lian, HUANG Yan-juan 513true ［Abstract］　Hepatitis B virus(HBV) is a hepadnavirus DNA virus. When the virus invades the body,it could cause HBV, because the immune response of body to HBV and its expression products would lead to liver cell damage and further stimulate body immune response with disturbance of immune regulatory function. TLR9 is an important pattern recognition receptor which generally recognizes bacterial or viral unmethylated CpGDNA, and it is closely related to the onset, treament and prognosis of patients with HBV. We review the research progress of TLR9 and its correlation with HBV in this paper.]]> 2017/12/6 8:06:37 REN Rong, MAO Xue-feng, TAN Yi 512true ［Abstract］　Currently,with gradual increase of immunocompromised population, invasive pulmonary aspergillosis(IPA) has become one of the main pulmonary infectious diseases resulting in the death of severe immunocompromised patients, such as patients who received organ transplants, long-term use of corticosteroid hormone or chemotherapy for cancers, or suffered from chronic granulocytopenia, leukemia, HIV infection, or other critical diseases.However, IPA infection needs to consider several factors synthetically, including clinical manifestation, immune state, occupational history and so on, and use many kinds of laboratory diagnosis methods to confirm the diagnosis. The limitation of traditional examination method makes the diagnosis of IPA more difficult and easily misdiagnosis, wrong therapy, which lead to delayed treatment or overtreatment, increasing of fatality rate of IPA, so it is vital to diagnose IPA quickly and accurately in early stage. In summary, the thesis gathers many documents at home and abroad about research achievements of IPA in early diagnosis, in order to provide a reference for improving the level of IPA clinical diagnosis.]]> 2017/12/6 16:26:21 DUAN Shi-huan, QIN Zhi-qiang 511true ［Abstract］　In recent years, with the concept change from cataract rehabilitation surgery to reractive surgery and the increase of cataract patients′ expectation vaule for postoperative visual acuity rehabilitation, it is necessary to put foward higher requirments for accurate measurement of intraocular lens before cataract surgery. There are two main factors influencing the measurement of inraocular lens(IOL) power: the IOL power calculation formula selection and biological measurement of the eyeballs. In this paper, the above two main factors influencing the IOL power were summarized.]]> 2017/12/6 16:26:21 XIAO Xin-an, HU Qiu-ming, LI Chao-yin, et al. 510true ［Abstract］　Combined oral contraceptive（COC） is one of the most frequently used contraception drugs worldwide, and researches on COC has become one of the most intensively investigated area in gynecology. The early discovery of COC, current status of its clinical use, and trends of new oral contraceptive are reviewed in this paper.]]> 2017/12/6 16:26:21 HUANG Li-dong, WU Yu-ying, YANG Liu, et al. 509true ［Abstract］　Intra-abdominal hypertension(IAH) and abdominal compartment syndrome(ACS) are common in acute and severe patients, especially in abdominal injury patients, which have a high morbidity and mortality and seriously affect the prognosis of patients. Taking positive and effective measures to prevent IAH, and early giving medical treatment to the patients who may appear ACS, will improve the survival rate and improve the prognosis. We briefly review the progress on the diagnosis and treatment of IAH and ACS in this paper.]]> 2017/12/6 16:26:21 PAN Guan-ning, TAN Yi 508true ［Abstract］　Currently bile duct jejunum Roux-en-Y anastomosis is clinically used for a variety of biliary disorders. Its surgical clinical results are satisfactory. However, retrograde biliary tract infection after bile duct jejunum Roux-en-Y anastomosis brings physical and mental suffering for patients, and has a serious impact on the prognosis of patients. Therefore, positive prevention and treatment for biliary tract infection after bile duct jejunum Roux-en-Y anastomosis is of great significance. In this paper, the research progress on retrograde biliary tract infection after bile duct jejunum Roux-en-Y anastomosis is reviewed.]]> 2017/12/6 16:26:21 TANG Lei, TAN Yi 507true ［Abstract］　In recent years, there are a lot of progress in these areas of gastrointestinal stromal tumor(GIST) include molecular markers, gene detection, targeted therapy drugs efficacy assessment. Discovery of DOG1, PKC-θ, ETV1 and other new markers helps to improve the detection rate of GIST, and provide new direction for discovering special therapeutic targets. Currently imatinib as first-line drugs for targeted therapy has great significance for improving the prognosis of patients with GIST, mechanisms of drug resistance and the development of new targeted drugs still need further exploration and research. In this paper, the recent advances in molecular pathological diagnosis and targeted therapy of GIST were reviewed.]]> 2017/12/8 8:10:57 NONG Tao, YIN Wu, ZHONG Xiao-gang 506true ［Abstract］　Anal fistula is a common anorectal disease. There were many surgical modes for it, but no golden standard treatment for complex anal fistula.Anal incontinence and recurrence are two important unsolved problems after traditional surgery. Minimally invasive surgery does not damage the anus appearance and function, and will largely replace traditional surgery. We review the research progress of anal fistula surgery in this paper.]]> 2017/12/8 8:10:57 LIN Jia-wei, HUANG Shun-rong, FENG Ze-rong 505true ［Abstract］　Bipolar disorder etiology is unknown so far, the studies related to family, twins and adoption suggest bipolar disorder have a genetic predisposition, the scholars both at home and abroad have performed a lot of research work for its pathogenic gene. Many studies about the disease susceptibility genes have been reported, some results in the subsequent test achieve good repeatability. We review the research status of susceptibility genes for bipolar disorder in this paper.]]> 2017/12/8 8:10:57 SONG Sha-fei, LI Wei-dong, LIU Min-hui, et al. 504true ［Abstract］　Cervical intraepithelial neoplasia(CIN) is a group of cervical lesions that are closely associated with cervical cancer, and high-risk human papilloma virus(HR-HPV) infection is one of the causes of CIN,hence the study of HR-HPV has an important significance in CIN′s early diagnosis, treatment and evaluation of the treatment effect. In this paper, we review the research progress of CIN and HR-HPV.]]> 2017/12/8 8:10:57 XU Li-li, ZHAO Ren-feng 503true ［Abstract］　In the treatment of diabetes, a patient′s self-management is very important. Improving a patient′s self-management ability should be helpful in improving disease conditions, reducing complications and improving the quality of life and prolonging the life span. In recent years,scholars at home and abroad have made a lot of research work on self-management of patients with diabetes mellitus. In this paper, research progress on self-management of patients with diabetes mellitus and its intervention is briefly introduced.]]> 2017/12/8 8:10:57 LUO Jian-she, LI Gui-hong 502true ［Abstract］　The pathogenesis of hepatocellular carcinoma(HCC) is a cancer with high morbidity and mortality, its early diagnosis and treatment is still very difficult. Emerging evidences indicate that MicroRNAs(miRNAs) can play roles of oncogenes or tumor suppressor genes in the pathogenesis of HCC,by regulating all aspects of basic cellular processes, including the regulation of cell cycle and apoptosis. This paper reviews the role of miRNAs in regulation of cell cycle and apoptosis of HCC.]]> 2017/12/12 9:29:09 LI Wen-wei, YANG Jian-rong 501true ［Abstract］　Periprosthetic femoral fractures is a rare complication in total hip arthroplasty, and the administration for this fracture still has not reached a consensus. In recent years, the incidence of this fracture is becoming higher. In this article, the research progress on reason, classification and treatment of periprosthetic femoral fractures are reviewed.]]> 2017/12/12 9:29:09 QIN Wen-jie, YIN Dong 500true ［Abstract］　Ki-67 antigen is a kind of nonhistone nucleoprotein, which presented in the proliferating nuclei, is closely related to cell proliferation and also related to the differentiation, invasion and the prognosis of many tumor. This paper reviews the significance of Ki-67 antigen expression in the assessment of treatment efficacy and prognosis of the diffuse large B-cell lymphoma.]]> 2017/12/12 9:29:09 ZHOU Rui-lian, LIN Jin-ying 499true ［Abstract］　Chronic kidney disease prevention has become an important global public health problem and there are about 1.2 million patients with end-stage renal disease undergoing hemodialysis treatment around the world. In China, the maintenance hemodialysis(MHD) is the main treatment of patients with end-stage renal disease. With the continuous development of hemodialysis technologies, the prognosis of MHD patients improve significantly, however, the long-term survival rate is still low. This article elaborates on the influence factors associated with survival rate of patients with MHD.]]> 2017/12/12 9:29:09 DING Yan-ping, SHI Hong-bin 498true ［Abstract］　As a very important component in image-guided radiation therapy(IGRT), cone beam CT(CBCT) is the 3D imaging system directly incorporated into a linear accelerator. In the process of intensity-modulated radiation therapy(IMRT) in head and neck cancer, CBCT can test and adjust the beam position error, reduce the external boundary, resulting in improved accuracy of radiotherapy. In addition, CBCT can also be used for dose calculation, which makes dose-adaptive radiation therapy possible. Flaws for CBCT include poor image quality secondary to lateral scattered radiation and unnecessary radiation exposure for patients during image acquisition. In this paper, we review the CBCT imaging system and its application in head and neck cancer.]]> 2017/12/12 9:29:09 LIU Xu, LU He-ming 497true ［Abstract］　Angiopoietins(Ang) are a group of secreted growth factors. Ang specifically effect on blood vessel endothelial cells, may participate in the formation and regulation of new blood vessels. Under the stimulating of abnormal factors such as anoxia, high sugar and inflammation factors Ang participate in occurrence and development of diabetic microangiopathy. Ang,their receptor(Tie-2) and vascular endothelial growth factor(VEGF) jointly participate in physiological and pathological angiogenesis.This article reviews the research progress on expression and regulation function of Ang in diabetic microangiopathy.]]> 2017/12/12 9:30:01 HUO Ya-jie, WEN Yu-jie, LIU Tao-wen 496true ［Abstract］　After treatment of nasopharyngeal carcinoma(NPC), there are still residual and recurrence. Studies have shown that, the effective treatments of residual and recurrence are only radiotherapy and surgery. But secondly radiotherapy has poor results, and more sequelaes. Because of unclear operative field, large trauma, more blood loss and postoperative scar formation, the majority of patients feel difficult to accept conventional surgery. With the extensive application of the nasal endoscopic surgery, nasal endoscopic surgery shows its advantage in the treatment of NPC residual or recurrence. This paper compares the survival and quality of life between endoscopic surgery and secondly radiotherapy in patients and expounds the feasibility of applying the nasal endoscopic surgery in NPC residual or recurrence.]]> 2017/12/12 9:30:01 HUANG Bo, SI Yong-feng 495true ［Abstract］　Contrast-induced nephropathy（CIN） is a serious complication after using angiography contrast material.It is the third common hospital-acquired acute kidney injury.The pathogenesis of CIN is still not entirely clear. Some studies have proved that statins are of great significant for preventing CIN. Although some patients need to use dialysis treatment, support treatment is still the main method for CIN, including careful inputting and correcting liquid electrolyte. Therefore, the best treatment is prevention. This paper mainly reviews the epidemiology and pathogenesis of CIN, and the effect and possible mechanism of statins in prevention of CIN.]]> 2017/12/12 9:30:01 LUO Jun-chao, GONG Zhi-feng 494true ［Abstract］　Lung cancer has the characteristics of high morbidity and high mortality. Early detection, diagnosis and treatment of lung cancer has great significance to reduce the mortality and improve the prognosis. The detection of serum tumor markers plays an important role. In this article the progress of research on serum tumor markers in lung cancer is summarized.]]> 2017/12/12 9:30:01 GAO Feng, TAN Yi 493true ［Abstract］　Biliary calculi is one of clinical common diseases, and is always one of the difficult problems in clinical treatment, because of its easy recurrence. Biliary calculi is usually treated by surgery, including electrohydraulic lithotripsy(EHL) which has the advantages of higher stone removal rate and low recurrence rate, and was a safe and effective method.This paper focuses on EHL application in the surgical treatment of biliary calculi.]]> 2017/12/12 9:30:01 LI Hong-fei, HUANG Qing-lu, HUANG Ke-zeng, et al. 492true ［Abstract］　The surgery which is named coronary artery bypass grafting, is one of the internationally recognized and mainly surgical treatment of coronary atherosclerosis. Currently, there are several methods for treating the disease of coronary atherosclerosis by surgery, such as conventional extracorporeal circulation coronary artery bypass grafting(CECC-CABG), minimized extracorporeal circulation coronary artery bypass grafting(MECC-CABG), off-pump coronary artery bypass grafting(OPCAB), minimally invasive direct coronary artery bypass surgery(MIDCAB),robotic CABG(r-CABG) and so on. This paper reviews the characteristics of these surgical methods, compares them between each other and makes some speculations on the future development of the coronary artery bypass grafting.]]> 2017/12/12 9:30:01 WANG Teng-fei, NIU Jian-hua 491true ［Abstract］　Hypertensive cerebral hemorrhage refers to the parenchymal spontaneous bleeding secondary to hypertension. There are various surgical ways for treating this disease, among which the small bone window craniotomy to remove hematoma has some unique advantages. In this paper,research progress of small bone window operation in the treatment of hypertensive cerebral hemorrhage is reviewed.]]> 2017/12/18 8:27:00 HU Shuan-gui,FAN Xue-zheng,HUANG Jin-neng, et al. 490true ［Abstract］　People infected with human immunonedeficiency viruses(HIV) and acquired immune deficiency syndrome(AIDS) are becoming younger and younger. Medical students are not only the object of AIDS health education, but the major force for promotion of AIDS prevention in the future. Therefore, the prevention and control of AIDS is important foundational work for the school health education. In this paper, the necessity, pattern and interventional effects of AIDS health education for medical students were reviewed.]]> 2017/12/18 8:27:00 YANG Hong-ye, TAN Yi 489true ［Abstract］　Unilateral pedicle screw internal fixation is one of the important means of treatment of lumbar degenerative diseases. It plays an important role on solving the postoperative immediate stability of the lumbar spine, and provide enough rigid internal fixation for intervertebral fusion.This paper expounds the research present situation, advantages, limitations and future research direction of unilateral pedicle screw internal fixation.]]> 2017/12/18 8:27:00 GU Jin, LIANG Bin 488true ［Abstract］　Multi-slice spiral CT angiography(MSCTA) is used more and more widely in the cerebralvascular diseases, and significantly improves the diagnostic level of cerebralvascular diseases. This paper reviews the clinical application of MSCTA.]]> 2017/12/18 8:27:00 DAI Li-hua, LIU Ying, TAN Yi 487true ［Abstract］　Glucose-6-phosphate dehydrogenase(G6PD) deficiency is an X-linked incomplete dominant genetic hemolytic disease that afflicts millions of people worldwide. The clinical detections of G6PD deficiency includes qualitative detection, quantitative detection, cytology testing, genetic testing and so on. In this paper, various detection methods for G6PD deficiency are reviewed.]]> 2017/12/18 8:27:00 TANG Juan, TAN Yi 486true ［Abstract］　Extravascular lung water and pulmonary vascular permeability index have certain clinical values for the diagnosis, treatment and prognosis of critically ill patients. Their application is becoming valued more and more as an important monitoring index of pulmonary pathophysiology. We review the research progress on monitoring and application of extravascular lung water and pulmonary vascular permeability index in this paper.]]> 2017/9/12 9:14:26 XIANG Shu-lin, XIONG Bin 485true ［Abstract］　CD24 is an adhesion molecule as a newly discovered tumor marker and many studies have discussed the prognostic value of CD24 for different tumors recently. CD24 is a small cell surface protein molecule anchored by glycosyl phosphatidyl inositol in a wide variety of cancer cells which mediate adhesion and functions of cell-cell and cell-matrix interactions. Many studies indicated that CD24 expression was found in a variety of human tumors and was considered to be linked with invasion, metastasis and a poor prognosis of tumors. The present studies suggest that CD24 overexpression is a predictor of invasion, distant metastasis, decreased long-term survival and poor prognosis in patients with cervical cancer. Understanding and detection of CD24 expression in cervical cancer may provide some important clinical implications for therapeutic decision and prognosis judgement, and conduct some guides for the establishment of treatment strategy. CD24 may become an important biological marker to detect cervical cancer. The relationship between CD24 expression and the prognosis of cervical cancer is reviewed in this paper.]]> 2017/9/12 9:14:26 HUANG Wei-rong, WU Yu-ying 484true ［Abstract］　Thyroid nodule is one of the common endocrine diseases. Contrast-enhanced Ultrasound(CEUS) provides some information on the microvessels of the lesion. Acoustic radiation force impulse-imaging(ARFI) provides some information on the hardness of the tissues, which is of certain value in the differentiation of thyroid benign and malignant nodules. The research progress of the differential diagnosis of benign and malignant thyroid nodules by CEUS and ARFI technology is reviewed in this paper.]]> 2017/9/12 9:14:26 CHEN Xue-xue, WANG Xiao-yan 483true ［Abstract］　The effect of aspirin on the treatment of acute cerebral infarction has been clear. However, it can cause bleeding in the brain, especially in the patients with a history of cerebral hemorrhage and acute cerebral infarction, as a result, the benefits of aspirin may be offset by the risks caused by cerebral hemorrhage. In the clinical treatment of aspirin, it should be careful to consider the risks of its potential secondary cerebral hemorrhage. We review the progress of aspirin on cerebral hemorrhage and its clinical benefits in this paper.]]> 2017/9/12 9:14:26 ZHU Xin-hua, WANG Qia-ru 482true ［Abstract］　Obstructive azoospermia is one of the causes of male infertility. Its incidence has a rising trend year by year. In recent years, scholars have further studied for obstructive azoospermia and have a deeper understanding of them.This article reviews the new research progress in obstructive azoospermia′s risk factors, clinical diagnosis and treatment plans.]]> 2017/9/13 9:54:48 HE Yong-zhi, LI Da-wen, WAN li-kai 481true ［Abstract］　With aging, the number of patients with degenerative lumbar spinal stenosis is going up quickly. Its morbidity ranks only second to lumbar disc herniation among lumbar diseases. There are a myriad of strategies used by orthopedist to treat lumbar spinal stenosis. However, the standard treatment is still unclear and controversial. Currently, the selection of management depends mainly on a doctor′s experience, which raises many great challenges to choose reasonable and effective treatment measures.]]> 2017/9/13 9:54:48 MU Xiao-ping, WEI Jian-xun 480true ［Abstract］　With the speeding up of urbanization and industrialization in our country and the increasing in the number of rural young adults leaving home for jobs, the number of rural left-behind children shows an increasing trend. Accordingly, the related problems influencing rural left-behind children′s survival and development also are gradually revealed. In order to properly solve these problems, a comprehensive understanding of the relevant problems and taking the matching effective measures are particularly important. In this paper, a brief introduction of research progress on the nutritional status of rural left-behind children and its intervention measures are reviewed.]]> 2017/9/13 9:54:48 LIN Ru-jiao, FENG Rong-zuan, NONG Shan-wen, et al. 479true ［Abstract］　It is a common phenomenon that renal pelvis high pressure occurs during percutaneous nephrolithotripsy(PNL) and ureteroscopy. However, this phenomenon can be avoided. The related complications are common in clinic. In this paper, the research progress of renal pelvis high pressure related to the application of percutaneous nephrolithotripsy(PNL) and ureteroscopy is summarized. We mainly discuss renal pelvis high pressure related complications, their mechanisms, and prevention measures.]]> 2017/9/13 9:54:48 HUO Zhong-chao, LIU Gang 478true ［Abstract］　Allergic asthma is characterized by airway hyper-responsiveness and chronic airway mucosal inflammation which arises as a consequence of a defect in immune regulation. Pathogenic mechanisms underlying the development of airway inflammation are very complex and not yet entirely clarified. Regulatory T(Treg) cells play a key role in the maintenance and tolerance of immune regulation. T helper 17(Th17) cells typically promote neutrophilic inflammation, and also play important roles in airway hyperresponsiveness. Recently, research on mechanism of asthma has focused on the imbalance between Treg and Th17 cell phenotype. The purpose of this review is to discuss recent findings of the role of these novel populations in allergic asthma and to highlight the pleiotropic effects of these subsets on the development and regulation of airway inflammation.]]> 2017/9/15 8:39:15 QIN Xue-jun, YIN Wei-mou, TAN Yi 477true ［Abstract］　Evaluation of tubal patency is an important link in the process of diagnosis and treatment of infertility. There are several methods of evaluation of tubal patency. In recent years, with the continuous development of imaging technology and ultrasound contrast agents, hysterosalpingo-contrast sonography is gradually applied in clinic, and has acquired a great of achievements. This paper focuses on the clinical application and development of contrast-enhanced ultrasound in the diagnosis of fallopian tube patency.]]> 2017/9/15 8:39:15 CHENG Ping, ZHAO Wei-dong, TAN Yi 476true ［Abstract］　As an entirely new genome amplification technology to provide sufficient and stable DNA for subsequent detection of single cell, multiple displacement amplification(MDA) has acquired a great progress in experimental research and clinical application in preimplantation genetic diagnosis of thalassemia. In this review, we introduce the principles of MDA, technical characteristics and research progress in preimplantation genetic diagnosis of thalassemia.]]> 2017/9/15 8:39:15 WANG Shi-kai, HUANG Li, HE Bing 475true ［Abstract］　Azithromycin is one of the macrolide antibiotics with unique pharmacokinetic characteristics. It is effective and widely used in the treatment of mycoplasma pneumonia in children. In this paper, we review azithromycin in the treatment of mycoplasma pneumonia and its mechanism, conventional therapy, sequential therapy and combination therapy.]]> 2017/9/15 8:39:15 XIE Sheng-quan, TAN Yi 474true ［Abstract］　Preoperative skin preparation plays an important role in preventing incision infection and improving wound healing, which directly influences the surgical effect. Gynecological laparoscopy is a minimally invasive surgical technique, and has been applied widely on the treatment of gynecological diseases. However, it is still controversial to perform preoperative skin preparation for gynecological laparoscopy surgery. In order to improve the clinical care nursing effect, we review the progress of preoperative skin preparation for gynecological laparoscopy in this paper.]]> 2017/9/15 8:39:15 ZHANG Jing, ZENG Jing-hua, XIA Xiu-fang, et al. 473true ［Abstract］　The relationship between microRNA and malignant tumors is the research focus of oncomolecularbiology. The correlation between them involves various aspects including the occurrence, development, diagnosis, treatment and prognosis of malignant tumors. In this paper, we review the research progress of microRNAs in human malignant tumors.]]> 2017/7/13 10:28:25 XU Yu-biao, YANG Jian-rong 472true ［Abstract］　With the improvement of living standard and the changes of dietary pattern, the incidence of hypertension in adolescent is gradually increasing. More attention should be put to the prevention of hypertension, and the identification of high risk population with hypertension during adolescence is helpful to the early effective intervention and treatment to reduce the incidence of hypertension on adults. The epidemiological characteristics, diagnostic criteria, risk factors and target organ damage of hypertension in adolescents are reviewed in this paper.]]> 2017/7/13 10:28:25 QIN Yong-sheng, LIANG Ling 471true ［Abstract］　Due to knowing the diagnosis of cancer and being afflicted by a variety of uncomfortable symptoms and a variety of complex treatments(such as surgery, chemotherapy, radiation, etc.) and other factors affecting the quality of sleep, the cancer patients have many sleep disorders. Sleep disorders can lead to serious problems in various systems of the body, including the immune system, the cardiovascular circulatory system, the endocrine system and the nervous system, and affect the patients′ physiological and psychological health, clinical outcomes and the quality of life. The concept of sleep disorders, the examination and treatment of sleep disorders in cancer patients are reviewed in this paper.]]> 2017/7/13 10:28:25 ZHOU An-xiu, QIN Hai-jiao, LIANG Wu-qing 470true ［Abstract］　Preeclampsia(PE) is one of the specific diseases during pregnancy. Many researches show that the changes of the blood coagulation function during pregnancy are the main causes of PE, and a reasonable application of anticoagulant therapy can effectively prevent and treat the disease and its complications. Low molecular weight heparin and aspirin are the most commonly used anticoagulant drugs. In this paper, the studies on the application of the two drugs in the prevention and treatment of PE are reviewed.]]> 2017/7/13 10:28:25 WEI Xiu-yan, WANG Su-mei 469true ［Abstract］　The percutaneous nephrolithotomy（PCNL） is the most common surgery in the treatment of urolithiasis. The operative positions of PCNL include the prone position, supine position, lateral position and oblique supine position. We review the current research progress of the surgical postures for PCNL, and analyse the advantages and disadvantages of every position to provide helpful reference for choosing the most appropriate position for PCNL.]]> 2017/7/13 10:28:25 XU Lian-hang, LI Xiao-yan 468true ［Abstract］　Cholestasis is the main complication of parenteral nutrition in premature infants. The incidence of cholestasis associated with parenteral nutrition is related to premature, genetic susceptibility, parenteral nutrition formula, endotoxin, and intestinal mucosal barrier. In this paper, the pathogenesis of cholestasis associated with intravenous nutrition in preterm infants are reviewed.]]> 2017/7/13 10:29:15 ZHEN Hong, DU Hua 467true ［Abstract］　EGFR-TKIs is the first-line treatment of EGFR sensitive mutations in patients with advanced non-small cell lung cancer. However, the emergence of acquired drug resistance is inevitable. There are a variety of mechanisms for secondary drug resistance, of which EGFR T790M mutation is one of the main mechanisms. Currently, combinations of different molecular targeted drugs in the treatment of lung cancer secondary resistant to EGFR-TKIs are the important strategies. Their research progress is reviewed in this paper.]]> 2017/7/13 10:29:15 HUANG Dong-ming, FENG Guo-sheng 466true ［Abstract］　With the development of minimally invasive and visual technology, video-assisted thoracoscopic cardiac surgery has made rapid progress in recent years. A large number of clinical researches at home and abroad indicate that sufficient preoperative imageological examination, intensified Doppler ultrasonography monitoring during operation, fast-track anesthesia and effective one-lung ventilation lung protective strategy are the main points of anesthesia management in video-assisted thoracoscopic cardiac surgery. The research progress of anesthesia management in video-assisted thoracoscopic cardiac surgery is reviewed in this paper.]]> 2017/7/13 10:29:15 CHEN Xian, TAN Wen-hao 465true ［Abstract］　Hoarding disorder is a kind of mental disorders featured with persistent difficulty in discarding or parting with possessions. Many researches have showed that the etiology of hoarding disorder can be illustrated in the aspects of psychology, cognition and heredity. The etiology is also related to age, gender, traumatic events and obesity. These studies have significances on exploring the etiology of hoarding disorder.In this paper, we review the research progress on the etiology of hoarding disorder.]]> 2017/7/13 10:29:15 HUANG Qian, QIAO Wen-da 464true ［Abstract］　Aflatoxin B1(AFB1) and hepatitis B virus(HBV) are the major high risk factors of hepatocellular carcinoma(HCC) in Guangxi Zhuang Autonomous Region of China. The synergism of AFB1 and HBV inducing HCC is 30～60 times stronger than the induction of HCC by the single factor HBV. However, to date, the role and mechanisms of AFB1/HBV-induced HCC have not been known clear yet. The possible related factors of the occurrence of HCC in the high incidence area of Guangxi are summarized in this paper to provide the basis for the prevention and treatment of HCC.]]> 2017/7/13 10:29:15 CHEN Ke-he, CHEN Jia-xin 463true ［Abstract］　Early studies of traditional circumcision have been innovating and upgrading, In the last decade, the researches began to shift to the equipment type, showing the unique advantages: shorter operative time, better cosmetic penile appearance, and so on. However, some defects still exist in it. The surgical methods, indications and complications of circumcision are reviewed in this paper.]]> 2017/8/4 9:07:51 HUO Zhong-chao, LIU Gang 462true ［Abstract］　Ocular adnexal mucosa-associated lymphoid tissue lymphoma is a class of low malignant B cell non Hodgkin′s lymphoma, which occurs in many parts of the human body, such as conjunctiva, lacrimal gland, eye and eyelid. It affects not only normal function of eyes, but also the quality of life. The current treatment methods include surgical resection, radiotherapy and chemotherapy, antibiotic to eradicate Chlamydia psittaci(CPS), and immune therapy. In this paper, we review the treatment progress of ocular adnexal mucosa-associated lymphoid tissue lymphoma.]]> 2017/8/4 9:07:51 WU Yu, ZHANG Jiu-ming 461true ［Abstract］　Female pelvic floor dysfunctional diseases for postpartum are the common diseases in middle-aged and eldly women. They are the research hotspots in the field of gynecology and obstetrics in recent years. The defects of pelvic and genital tract support tissues, and the lack of the support of the normal tissue function result in the abnormal pelvic floor structure and function, including pelvic organ prolapse, stress urinary incontinence and chronic pelvic pain, which seriously impact the women′s physical and mental health and the quality of life. In this paper, the pathological mechanism of pelvic floor dysfunction, the clinical diagnosis and treatment methods are reviewed.]]> 2017/8/4 9:07:51 GONG Tian-liu, YAN Si-ping 460true ［Abstract］　Post abortion care(PAC) plays an important role in reducing the rate of repeated abortion and protecting mental and reproductive health in induced abortion women. We summarise the concept, significance, content and development process of PAC, and the positive effect of PAC on the patients′ mental and reproductive health in this paper. We introduce the importance of PAC for HIV/AIDS patients with early abortion as well.]]> 2017/8/4 9:07:51 WU Zhu-hong, ZHANG Bi, QING Rong-zhen 459true ［Abstract］　Variability is a hallmark of the human immunodeficiency virus type 1(HIV-1), which can be divided into 9 subtypes and 78 circulating recombinant forms(CRFs). HIV-1 subtypes are not evenly distributed around the world, and the diversity of HIV-1 subtypes may exert an influence on transmission routes, infectivity, virulence, disease progression, drug susceptibility, drug resistance and vaccine development and brings great challenges for AIDS prevention and treatment. The research progress of various HIV-1 subtypes is reviewed in this paper.]]> 2017/8/8 16:30:41 SU Qi-jian, TAN Yi 458true ［Abstract］　Iatrogenic pseudoaneurysm(IPSA) is one of the complications after arterial puncture and interventional diagnosis or treatment.With the development of catheterization, the incidence of IPSA has risen dramatically in recent years. The advance of color Doppler ultrasound in the diagnosis and treatment of IPSA is reviewed in this paper.]]> 2017/8/8 16:30:41 LAN Chun-yong, WANG Xiao-yan 457true ［Abstract］　Interventional therapy plays an increasingly important role in the multidisciplinary treatment of pernicious placenta previa.It can effectively control postpartum haemorrhage during placental dissection, and reduce transfusion requirements as well as the risk of hysterectomy. The research progress of the interventional therapy in the treatment of pernicious placenta previa in women with caesarean section is reviewed in this paper.]]> 2017/8/8 16:30:41 LIU Zhi-yong, YU Lei 456true ［Abstract］　With the development of cochlear implant and the wider diagnostic criteria of cochlear implantation, more and more patients with severe hearing loss in both ears receive surgery and can talk to other people in their daily life. Binaural devices are used to perform cochlear implantation, including binaural cochlear implant, monaural cochlear implant and contralateral hearing aid. In this paper, the basic psychophysical knowledge of binaural hearing, the choice of bimodal stimulation, and shortage in the technique of binaural stimulation are reviewed.]]> 2017/8/8 16:30:41 PENG Lu, LIANG Jian-ping 455true ［Abstract］　Hand-foot-mouth disease mostly develops in preschool children, with the highest incidence of reported cases occurring in children under the age of three years. As a common disease in children, there is no specific treatment. The disease epidemically occurs once every 2～3 years, with a few cases becoming severe and life-threatened, which seriously affects the children′s physical and mental health. With the increase of population in children, it is important to take effective measures for the prevention and control of hand-foot-mouth disease. In this paper, we mainly review the research progress on epidemiology, prevention and treatment of hand-foot-mouth disease.]]> 2017/8/8 16:30:41 MA An-xiang, WEI Qi-ping 454true ［Abstract］　Dexamethasone is a type of long acting glucocorticoid with low price, less side effects and convenience to use. Currently it has been used to relieve the patients′ clinical symptoms and improve the perioperative period of anesthesia. The research progress of dexamethasone in the treatment of the elderly patients with stress response during laparoscopic surgery is reviewed in this paper.]]> 2017/8/8 16:30:41 GONG Zheng, MA Li 453true ［Abstract］　Membranous nephropathy is one of the common causes of adult nephritic syndrome, and its incidence has been on the rise significantly. As a kind of autoimmune disease, membranous nephropathy is generally recognized to be caused by the deposition of immune complex formation under the glomerular basement membrane epithelium as a result of B lymphocyte proliferation and activation stimulated by T lymphocytes, but its specifical pathogenesis remains unclear. Peripheral blood lymphocyte subsets become a research hotspot in recent years. This paper aims to highlight the immunological research advances of T lymphocyte subsets and B lymphocytes in idiopathicmembranous nephropathy, so as to provide a novel target for the prevention and treatment of idiopathic membranous nephropathy.]]> 2017/8/10 9:01:20 LONG Teng-xiang, YE Kun 452true ［Abstract］　Coronary atherosclerotic heart disease threatens human health seriously. According to statistics from the World Health Organization, coronary heart disease is the first leading cause of death globally each year. The value of aVR lead is not mentioned in the diagnosis of myocardial infarction and myocardial ischemia in conventional electrocardiogram(ECG), therefore it is often ignored in clinics. Recent researches show that ST segment elevation or ST segment depression in aVR lead indicates severe left main coronary artery lesions or left anterior descending proximal lesions or three vessels lesions, and poorer prognosis. ST segment changes in aVR lead have significant clinical value for diagnosing and evaluating myocardial infarction, including the scope of coronary artery lesion and severity, and short-term prognosis. In this paper, the research progress of the changes of ST segments in aVR lead in diagnosis of acute coronary syndrome(ACS) is reviewed.]]> 2017/8/10 9:01:20 HONG Ji-ge, ZHANG Qin 451true ［Abstract］　Pulmonary surfactant(PS) has been conventionally used for prevention and treatment of neonatal respiratory distress syndrome(NRDS). A large number of literature on the clinical effects, the mode of administration, and the dosage of PS for the treatment of NRDS have been reported, but there are few researches on the optimal time of administration at present. The time of administration is closely related to the purposes of administration, including a prophylactic administration in the early stage, an alternative therapy for salvaging administration in the middle stage and a rescuing and repeated administration in the late stage of NRDS. Due to the different medical conditions and concepts of using PS, different time intervals of administration of PS have been reported in different parts of China. How to effectively administer PS in different patients in different levels hospitals needs to be further investigated. In this paper, the time of administration of PS for the treatment of respiratory distress syndrome in premature infants is reviewed.]]> 2017/8/10 9:01:20 HUANG Hong-kun, LIAO Ke-zhun, WEI Hai-lin, et al. 450true ［Abstract］　Many studies have found that children still suffer from huge psychological pressure and anxiety disorder although drug intervention may prevent them from memorizing the operative process, before and after the operation and during the anesthesia induction. Currently a variety of psychological behavior interventions have been studied to reduce the perioperative psychological anxiety in children. The behavior intervention modes are reviewed in this paper.]]> 2017/8/10 9:01:20 HE Si-ling, WAN Fu-hong, LIANG Ning 449true ［Abstract］　With the society developing,the incidence of deep vein thrombosis(DVT) is increasing day by day. Specifically after total hip replacement(THR）and total knee arthroplasty(TKA）, DVT occasionally happens, which has brought huge suffering and financial burden on patients. As a result, the orthopedics doctors have paid more attention to this phenomenon, and medication is the main measure to prevent DVT. The research progress of medication on preventing DVT after THR and TKA is reviewed in this paper.]]> 2017/8/10 9:01:20 LI Fu-lin, YIN Dong 448true ［Abstract］　Bladder cancer is one of the most common malignant tumors in the urinary system, which is divided into two types in clinic: bladder carcinoma with non muscular layer and muscular layer（T2 and above）. The former which referred to superficial bladder cancer in the past accounts for 70%, including in situ carcinoma(Tis), Ta and T1. Bladder cancer grows surfacely and invasively, with the characteristics of recurrence and metastasis. There are some methods of the treatment of bladder cancer, but their clinical effects are not satisfying. In this article, we review the progress of bladder perfusion in the treatment of non-muscle-invasive bladder cancer.]]> 2017/8/10 17:32:15 LI Wei, LI Dong-hui, BAI Jin-liang 447true ［Abstract］　The incidence of obesity is increasing year by year. Obesity and its complications severely affect the body′s normal physiological function. In recent years, bariatric surgery, especially laparoscopic bariatric surgery, becomes more and more popular in the treatment of obesity. In this paper, we discuss the epidemiology, pathophysiology and treatment of obesity.]]> 2017/8/10 17:32:15 YANG Sheng-fu, WU Dong-bo 446true ［Abstract］　We review the mechanism of cervical vertigo in this paper, including cervical proprioception disturbance, vertebral artery factors, hook vertebral joint hyperplasia, transverse foramen stenosis, atlas pivot joint disorders, cervical soft tissue injury, sympathetic nerve stimulation, vertebra disorder and humoral factors, which provides a guidance for the further study on the mechanism of cervical vertigo.]]> 2017/8/10 17:32:15 GAO Xin, LV Ya-nan 445true ［Abstract］　There are varying degrees of abnormal fluid distribution and electrolyte imbalances in the third space, which is due to the stress response and systemic inflammatory response after surgical trauma. The third space effect after abdomen laparoscopic surgery is summarized in this article.]]> 2017/8/10 17:32:15 WANG Long, MAI Wei 444true ［Abstract］　The male fertility is affected by many factors, and sperm DNA damage is one of the research hotspots in assisted reproductive technology(ART). A number of factors can lead to the DNA strand breaks or make double-stranded DNA into single-stranded DNA. In this paper we review the damage factors of sperm DNA, including sperm production error, oxidative stress, abnormal assembling of chromatin, and the related diseases, which provides some basic information for elucidating the mechanism of DNA damage, and optimal spermatozoa selection in ART.]]> 2017/8/30 17:15:13 HUANG Yue-yue, XUE Lin-tao, HE Bing 443true ［Abstract］　Varicocele is one of the most common causes of male infertility. The main methods for current treatment of varicocele are surgery procedures, including the traditional open surgery, laparoscopic surgery, and microsurgery. In this paper, the operation methods, characteristics, indications, and complications of varicocele are reviewed.]]> 2017/8/30 17:15:13 LAN Jian-jiang, ZHENG Xian-ning 442true ［Abstract］　Dry eye is one of the most common problems in ophthalmology. Its signs include punctate epithelial erosions, hyperemia, low tear lakes, rapid tear break-up time and meibomian gland disease. Given a complicated complaint presentation and a variety of signs and symptoms, it would be beneficial if there was an inexpensive, readily available, and reproducible diagnostic test for dry eye.In this paper, research progress in diagnosis of dry-eye disease is reviewed.]]> 2017/8/30 17:15:13 LIN Quan, LIU Wei-min 441true ［Abstract］　Small brain lesions is a concept of medical imaging, with which the patients often have no clinical symptoms and signs. The recent researches show that small brain lesions are associated with cerebrovascular events, and may be an early sign of cerebrovascular events. The purpose of this paper is to summarize the relationship between small brain lesions and cerebrovascular events, to explore the related risk factors and to prevent the cerebrovascular events better.]]> 2017/8/30 17:15:13 ZHONG You-an, HE Rong-xin, LU Hui 440true ［Abstract］　IL-22 is a new type of cytokine, which is closely related to multiple autoimmune diseases and chronic inflammatory diseases. Recently, the research of IL-22 achieved new developments in cardiovascular diseases. IL-22 has close correlation with the progression and prognosis of atherosclerosis, viral myocarditis and heart failure. In this paper, we review the research progress of IL-22 in cardiovascular diseases.]]> 2017/9/1 11:34:47 SHI Ying, LIU Ling, JI Qing-wei, et al. 439true ［Abstract］　Dry eye occurs when there is inadequate tear volume or function resulting in an unstable tear film and ocular surface disease.Invasive tear film break-up time(BUT), which is the traditional examination of tear film stability, has certain limitations. New technologies, such as tearscope, tear film interferometry, in vivo confocal microscopy and oculus keratograph, have less invasion, better stability and repeatability. The examinations of tear film stability are reviewed in this paper to provide a reliable basis for the diagnosis and treatment of dry eye.]]> 2017/9/1 11:34:47 LAN Qian-qian, MAN Ping-yi, ZENG Si-ming 438true ［Abstract］　At present, more and more attentions are paid to thoracic vertebra diseases. Some situations which usually cause spinal canal relatively narrow such as spinal tumor, tuberculosis, fracture, dislocation, herniated disk, calcification of posterior longistudinal ligament often require surgical treatment.How to choose more appropriate surgical approaches is a problem for orthopaedic surgeons. A summary of commonly used thoracic vertebra surgical approaches and their development in recent years is reviewed in this paper.]]> 2017/9/1 11:34:47 ZHAO You, MA Guang-bin, HUANG Yong-ji, et al. 437true ［Abstract］　Cesarean scar pregnancy (CSP) is a relatively rare ectopic pregnancy.With the increase of cesarean section rate, the incidence of CSP shows a growing trend, which causes the attention of the obstetricians. In this paper, the progress of its clinical research is reviewed.]]> 2017/9/1 11:34:47 LIANG Chan-yu,TAN Yi 436true ［Abstract］　Chronic prostatitis or chronic pelvic pain syndrome(CP/CPPS) is the most common type of chronic prostatitis and their etiologies remain unclear. As the researches move along, scholars find that psychological factors are closely related to CP/CPPS. Psychological factors can influence CP/CPPS on the occurrence, development and treatment. This review focuses on the manifestations and the mechanism of psychological disorder in CP/CPPS patients as well as on the psychological treatment.]]> 2017/9/1 11:34:47 LI Pei-feng, LIU Gang 435true ［Abstract］　Previous studies show that vitiligo is a complex disease. Though routine therapies are important for the treatment of vitiligo, side effects and poor efficacy affect their applications and patients′ compliance. To provide an effective basis for the clinical therapy and clinical research of vitiligo, we searched the related articles published in recent 5 years, and found that western medicine combining with traditional Chinese medicine(TCM) was effective in the treatment of vitiligo with shorter time of treatment and lower incidence of adverse reactions. This study mainly summarizes the relative researches of vitiligo treated by western medicine combining with TCM and provides an effective approach and reference for the clinic treatment.]]> 2017/9/6 16:16:49 DU Li-xing, HOU Ya-lin, SUN Ya-ru, et al. 434true ［Abstract］　Graves′disease(GD) is an autoimmune thyroid disease and a few of GD associated with kidney injury were reported in the literatures. As kidney disease with concealed onset is hard to find, and GD patients mainly visit thyropathy doctors in normal time, the patients will not go to see nephrologists until the definite clinical symptoms or renal insufficiency occur. The pathogenesis of GD-associated nephrotic is not clear and no consensus has been reached on the treatment for the disease. In order to better understand GD-associated nephrotic,diagnosis in the early stage and intervention treatments, the clinical manifestations, pathogenesis, diagnosis and the treatments of this disease are reviewed in this paper.]]> 2017/9/6 16:16:49 HUANG Wen-tan, GONG Zhi-feng 433true ［Abstract］　L-carnitine is critical for the transportation of long-chain fatty acids across the inner itochondrial membrane for subsequent β oxidation and energy production. L-carnitine has been used as adjuvant therapy in hemodialysis, cardiovascular diseases and cancer patients receiving chemotherapy. L-carnitine also has been used in hematologic malignancies, but these applications are only limited to the experimental study. In this paper, we review the physiological function and the application of L-carnitine in the therapeutic advances of hematological diseases.]]> 2017/9/6 16:16:49 XU Li, TAN Yi 432true ［Abstract］　This paper summarizes the research progress of acute-poisoning at home and abroad, discusses some new ideas of dealing with acute poisoning in Guangxi, sums up the research process, method and results, and puts forward the problems existing in the research and the future vision.]]> 2017/9/6 16:16:49 JIANG Dong-fang, ZHANG Zhen-ming, CHEN Xue-dong, et al. 431true ［Abstract］　Omentin-1 is mainly excreted by visceral adipose tissue, which has the actions of anti-inflammatory, anti-oxidant, anti-atherosclerosis, increasing insulin sensitivity and dilating blood vessels. The expression of omentin-1 in the patients who have cardiovascular diseases, glucose and lipid metabolism disorders, insulin resistance or obesity is lower than that in the normal population in many studies, however it will elevate after aerobic exercise and weight loss. Omentin-1 may become a new target for the prevention and treatment of cardiovascular related diseases in the future.]]> 2017/7/4 9:03:45 JIANG Ling-yun, YAN Xiao-dong 430true ［Abstract］　Acute fatty liver of pregnancy can lead to acute hepatic function failure with a high mortality rate when treated with conventional medical therapy. The application of artificial liver in acute fatty liver of pregnancy(AFLP) elevates the survival rate and improves the prognosis. We briefly review the progress of artificial liver in the treatment of AFLP in this paper.]]> 2017/7/4 9:03:45 MO Zu-cong, HUANG Zhai, QIN Wen-bo, et al 429true ［Abstract］　In recent years, some studies have found that hyperhomocysteinemia plays an important role in the process of the occurrence and development of ischemic cerebrovascular diseases. The characteristics and metabolic pathways of homocysteine and the pathogenic mechanism and the treatment of hyperhomocysteinemia in cerebrovascular diseases are reviewed in this paper.]]> 2017/7/4 9:03:45 WEI Shi-wen, WEI Yu-lu, QIN Wei-han, et al 428true ［Abstract］　Bronchopulmonary dysplasia(BPD) is one of the most common diseases in NICU. Present studies show that BPD in premature infants is correlated with many factors, including heredity, immature lung development, oxygen toxicity, ventilator-induced lung injury, and infection. There is no special treatment but prevention at present. The research progress on prevention and treatment of BPD is reviewed in this paper.]]> 2017/7/4 9:03:45 JIANG Li-shuang, QIN Li-ping 427true ［Abstract］　Essential hypertension is a risk factor for cardiovascular disease. Immuno-inflammatory response induced by CD4⁺ T cells is an important pathogenic mechanism for primary hypertension. Recently, the research of CD4⁺ T lymphocyte subsets has made continuous new progress. In this paper, we review the research progress of CD4⁺ T lymphocyte subsets in primary hypertension.]]> 2017/7/10 17:13:59 YANG Zi-cong, SHI Ying, LIU Ling 426true ［Abstract］　Soluble triggering receptor expressed on myeloid cells-1(sTREM-1) is a cell-surface receptor expressed on neutrophils and monocytes, and belongs to the member of immunoglobulin super family, and may amplify the inflammation responses. Chronic obstructive pulmonary disease(COPD) is a chronic inflammation of the airways. As a biomarker, sTREM-1 has a certain effect on the repeated exacerbations of inflammation and the repeated attacks of COPD. This review mainly summarizes the relationship between sTREM-1 and COPD.]]> 2017/7/10 17:13:59 HAN Mei-ling, CHEN Shao-ping 425true ［Abstract］　Minimally invasive surgery(MIS) has been widely applied in degenerative disease, tumour, fracture of spine. The treatments of MIS in spine tuberculosis include percutaneous catheter drainage and rinsing, thoracoscopic and endoscopic surgery, debridement and reestablish spinal stability via mini-open incision with retractor. We review the progress of MIS in the treatment of tuberculosis of thoracolumbar spine in this paper.]]> 2017/7/10 17:13:59 JIANG Jian-zhong, GAN Feng-ping, TAN Yi 424true ［Abstract］　Idiopathic membranous nephropathy(IMN) is the most common cause of nephrotic syndrome in adults. About one-third of the IMN patients develop end-stage renal disease. The treatment of IMN has become a hot spot in recent years. Angiotensin-converting enzyme inhibitor(ACEI) and angiotensin receptor antagonists(ARB) are the main methods to treat IMN due to their reducing glomerular perfusion pressure and proteinuria and other mechanisms to protect the function of the kidneys. More and more medications have accumulated experience in the treatment of IMN including immunosuppressive agents, rituximab, traditional Chinese medicine, and adrenocorticotropic hormone(ACTH). We review the treatment progress of IMN in this paper.]]> 2017/7/10 17:13:59 PAN Qing-deng, ZENG Chun 423true ［Abstract］　Hypertension seriously affects the physical and mental health of the middle-aged and elderly patients and their quality of life. Effective drug intervention can improve the patients′ compliance, the rate of blood pressure control and the patients′prognosis. In this paper, we review the research progress of antihypertensive drugs, including medical intervention, the choice of drug intervention and the combination of antihypertensive agents.]]> 2017/7/10 17:13:59 LU Gan, YIN Rui-xing 422true ［Abstract］　Osteosarcoma（OS） is a common malignant bone tumor, which has been threatening human beings over the years. From early amputation to neoadjuvant chemotherapy with limb salvage operation and to the comprehensive treatment, great efforts have been made to solve this worldwide problem. This article summarizes the commonly used treatment of OS, the new research methods and the new treatment strategies.]]> 2017/7/10 17:15:23 JIA Bin, LI Chao-xu, KONG Xiang-yun, et al. 421true ［Abstract］　In recent years, with the cerebrovascular stenting used in clinic widely, perioperative complications of stenting have become common concerns to the neurointerventional physicians and the patients. Perioperative cerebral hemorrhage is the most serious complication, as the death rate is extremely high. The mechanism and prevention of perioperative cerebral hemorrhage of cerebrovascular stenting are reviewed in this paper.]]> 2017/7/10 17:15:23 QIN Zhu-gui, ZHONG Wei-zhang 420true ［Abstract］　Emerging evidence suggests that vitamin D might be implicated in asthma pathophysiology. In this paper, we review the current experimental and clinical evidence of the association between vitamin D and asthma or the immune system, including the effect of vitamin D on the severity of asthma.]]> 2017/7/10 17:15:23 CHENG Peng-ling, SONG Ying-fang, LAI Guo-xiang 419true ［Abstract］　Non-small cell lung cancer(NSCLC) is one of the malignant tumors with the highest mortality. Micro-ribonucleic acid(miRNA) is a non-coding single-stranded small RNA comprised of 18 to 23 bases. With the unique biological features, it may become a new target for the diagnosis and therapy of NSCLC.The research progress of miRNAs in the diagnosis and targeted therapy of NSCLC is reviewed in this paper.]]> 2017/7/10 17:15:23 WEI Si-zun, FENG Jie, ZHOU Ji-hong 418true ［Abstract］　Enhanced recovery after surgery(ERAS), also known as fast-track surgery, is a combination of various perioperative patient care methods integrating evidence-based interventions which reduce trauma stress and accelerate recovery in patients. ERAS protocols have been most extensively applied in colorectal carcinoma. The impact of ERAS protocols on stress reaction, immunity and insulin resistance in the patients with colorectal carcinoma is reviwed in this paper.]]> 2017/7/10 17:15:23 LI Lin-de, WU Dong-bo, FENG Ze-rong 417true ［Abstract］　Diabetic foot（DF） ulcer is one of the most severe complications, belonging to refractory wound. Matrix metalloproteinases(MMPs) have the effect of degrading extracellular matrix(ECM) and promoting cell migration and involve in all the process of wound healing. Tissue inhibitor of metalloproteinases(TIMPs) which inhibit MMPs overexpression is a specific inhibitor of MMPs. They play an important role in wound healing together. In this paper, the role of MMPs and TIMPs in diabetic foot ulcer wound healing is reviewed.]]> 2017/9/26 8:05:56 CHANG Xue-hong, CHANG Fang-yuan, DONG Jian-feng, et al. 416true ［Abstract］　Breast cancer is a high incidence of malignant tumors in women and its treatment mode is individualized and comprehensive. Although there are many related guidelines and more and more standardized regimens for the treatment, some therapies are still controversy. Ⅱa and Ⅱb stages are the early stage of breast cancer, in which the curative rate is high. Many controversies of radiotherapies focus on T1, T2, with 1～3 metastatic lymph nodes or non-metastasis in the patients, which are usually called “recurrence of moderate risk” in a myriad of literature reviews. Combining the treatment guidelines and norms of breast cancer of Chinese Anti-Cancer Association, with NCCN and ESMO guidelines, is helpful to understand the current status of treatment for breast cancer, and some therapeutic controversies on which radiation therapist should focus.]]> 2017/9/26 8:05:56 QIN Heng, CHEN Long 415true ［Abstract］　Irritable bowel syndrome(IBS) is a kind of multi-factors functional gastrointestinal diseases. Its incidence rate is high, which seriously affects the patients′ quality of life. At present, the main treatments of IBS include medication, psychological intervention, dietary regulation and exercise, howerer the curative effects of the treatments are not consistent and their impacts on the quality of life are still unclear. This review summaries the treatment methods for improving the quality of life in the patients with IBS.]]> 2017/9/26 8:05:56 HUANG Xiu-mei, LIANG Lie-xin 414true ［Abstract］　Multidrug resistance of malignant tumors is the bottleneck of anti-tumor treatment at present. More and more researchers pay attention to the relationship between epigenetics and multidrug resistance. As a promising new star in the field of epigenetics study, Silent information regulator 1(SIRT1) has become a hot research topic in recent years because of its relationship with multidrug resistance of tumors. SIRT1 is a key regulator of cellular physiology and pathological processes such as cell proliferation, differentiation, DNA damage and stress response, aging and tumor formation. In this paper, we review the anti-tumor effect of SIRT1 and its drug resistance to provide a new idea for the treatment of malignant tumors using SIRT1 modulators.]]> 2017/9/26 8:05:56 XIA Xiao-yan, ZHOU Xiao-ming, LI Yao-jun 413true ［Abstract］　Continuing nursing care plays an important role in health management for the patients with hypertension after discharging from hospital. Nowadays, the development of continuing nursing care is still at the early stage in China, and its clinical effect doesn′t work well. So, it is really urgent and necessary to develop an appropriate model of continuous nursing care, for there are billions of hypertensive patients who are waiting for the professional management. The intervention methods and their clinical effects, the remaining problems and possible solving ways for the continuous nursing care of hypertension are reviewed in this paper to provide more references for the further progression of continuing nursing care for hypertensive patients.]]> 2017/9/26 8:05:56 JIN Xian-ping, SHEN Mao 412true ［Abstract］　Recently, homocysteine(Hcy) has become a hotspot on the research fields of pathophysiology of related diseases, the targeted treatment and prognosis evaluation. With the development of the researches, although the pathogenesis of Hcy is not yet clear, it has been generally recognized that Hcy is a amino acid that can injury the blood vessels. In this paper, we summarize the relationship between Hcy and the main clinical common diseases as well as the general pathogenesis.]]> 2017/8/29 17:08:47 HU Yao-shi, ZENG Zhi-yu 411true ［Abstract］　Central serous chorioretinopathy(CSC) is a common macular disease, which is more common in young male adults. Its etiology and pathogenesis are unclear yet, but it has irreversible effects on the visual function when lasting for a long course, so early treatment is very important.In this paper, research progress in the treatment of central serous chorioretinopathy is reviewed.]]> 2017/8/29 17:08:47 ZHAO Jun-hua, HE Jian-feng 410true ［Abstract］　Breast cancer lists the first malignant tumor in women and is prone to invasion and metastasis, which dose great harm to women′s health. With the rapid development of the field of molecular biology, understanding of the mechanism of the occurrence and evolution of breast cancer have been deepening. The study of molecular biology and prognostic factors of breast cancer is becoming a hot topic. The chemokine receptor 3(CXC-chemokine receptor3, CXCR3) and P120 catenin(P120ctn) are related to the occurrence, development, invasion and canceration of the tumor. The progress of research on the relationship between CXCR3, P120ctn and the development of breast cancer is reviewed in this paper.]]> 2017/8/29 17:08:47 WANG Yong-sheng, WANG Ying-bin 409true ［Abstract］　Lumbar disc herniation is one of the common and frequently occurring diseases in department of orthopedics. It can cause chronic pain in the low back and lower limbs and other symptoms, which seriously reduces the quality of life in the patients. With the changes of the way people live and work, the number of the patients with lumbar disc herniation is increasing year by year, especially in young patients. Although the studies on the pathogenesis of the disease have never been stopped, its complex physiological and pathological changes, and the pathogenesis are still unclear. However, its researches in various fields have attained great achievements including the theories of mechanics, matrix metalloproteinases and immune inflammatory reaction. This paper summarizes the domestic and foreign literature on the pathogenesis of the disease, and provides a new guidance for the contemporary research.]]> 2017/8/29 17:08:47 YU Chao-jie, CHU Ye, LIANG Bin 408true ［Abstract］　Along with the accelerating aging process, mental health problems in the elderly have aroused great concern in the society. Depression is one of the most common mental disorders in the elderly, and the comprehensive rehabilitations, including physical rehabilitation, psychological rehabilitation and social rehabilitation are recommended to tread the senile depression. The research progress of senile depression is reviewed in this paper.]]> 2017/8/29 17:08:47 KANG Hong, TAO Jian-qing 407true ［Abstract］　Andrographolide is a bioactive diterpenoid extracted from a traditional herbal medicine named andrographis paniculata. Previous studies show that andrographolide has antitumor activity. Its antitumor mechanisms include cell apoptosis, cell cycle arrestment, growth factor signaling modulation, suppressing cellular migration and angiogenesis. Andrographolide is a potentially novel natural antitumor medicine. The research progress of andrographolide on anticarcinogenic action and its mechanisms is reviewed in this paper.]]> 2017/7/28 17:24:59 CHEN Bo-yi, QU Li-li, LIU Jian-sheng 406true ［Abstract］　Along with the progress of technology, dentin adhesive system tends to be clinical steps simplified and multi-functional. Although the related performances of dentin adhesive system have been improved, a number of shortcomings and deficiencies still need to be solved. The research progress on the properties of the contemporary dentin adhesive system is reviewed in this paper.]]> 2017/7/28 17:24:59 LUO Pan, SHI Chun-mei 405true ［Abstract］　At present, the research progress of vaccine for human immunodeficiency virus(HIV） prevention has developed slowly. Pre-exposure prophylaxis(PrEP) has been proved by a number of clinical trials to be effective for prevention of HIV infection in high-risk populations. World Health Organization(WHO) and the Centers for Disease Control and Prevention of USA announced a clinical practice guideline that PrEP was taken as a new HIV intervention measure to the high-risk populations to reduce the rate of new HIV infections. Because PrEP becomes a public policy that needs to be extended, its cost- effectiveness must be known. The health economic evaluation of PrEP is reviewed in this paper.]]> 2017/7/28 17:24:59 WEI Suo-su, WU Teng-yan, TAN Yi 404true ［Abstract］　Explosive deafness is a common occupational disease, especially for the military personnel. Explosive deafness is the primary blast injury caused by blast waves, which can induce blast damage to the outer ears, middle ears and inner ears and lead to a series of clinical symptoms, such as deafness, tinnitus and earache. Recently, several studies suggest that blast not only caused mechanical injury of auditory system, but also initiated a series of molecular cascade reactions and cellular processes, such as increasing oxidative stress, decreasing cochlear blood flow, blood vessel contraction, glutamate excitability toxicity, and increasing calcium concentration in cells. Finding safe and effective interventions that attenuate explosive deafness according to these molecular mechanism will be helpful for the prevention and treatment of acquired hearing loss. The progress of research on explosive deafness is reviewed in this paper.]]> 2017/7/28 17:24:59 LIU Tong, CHEN Zi-long, ZHU Xiao-fen 403true ［Abstract］　Bedside ultrasound is an important examination in an intensive care unit(ICU). It is widely used with intensivists more understanding of the relationship between ultrasound and the physiology of related diseases. Bedside ultrasound can help the intensivists to evaluate diseases more promptly and comprehensively. In this paper, we review the progress of applying bedside ultrasound in ICU.]]> 2017/7/28 17:24:59 HUANG Dong-mei, HAN Lin 402true ［Abstract］　Lung cancer has become the first leading cause of cancer death. Degradation of the extracellular matrix and the basement membrane, which depends on the matrix metalloproteinases(MMPs) is necessary for the formation, growth and metastasis of lung cancer. Many studies have confirmed that MMP-10, one of the MMPs, plays an important role in the above developing processes of lung cancer. In this paper, we review the research progress of MMP-10 in lung cancer.]]> 2017/7/28 17:24:59 HUANG Si-guang, QIN Jian-ying, ZENG Jian-ye 401true ［Abstract］　Upper urinary tract calculi, including kidney stones and ureteral stones, are one of the common diseases of the urinary tract. Non-enhanced CT is the gold standard for the diagnosis of urinary calculi, and can initially predict the composition of the stones by measuring the CT values. Developing an ideal treatment method according to the different compositions of the stones is helpful to improve the curative effect and to reduce the complications. Analyzing the chemical compositions of the stones can prevent the recurrence of upper urinary calculi better after operation. With the improvement of CT equipment and CT image processing technology, the measurement of CT has good applications on predicting the stone compositions and the surgical effects. The research progress of prognostic value of CT on predicting upper urinary calculi is reviewed in this paper.]]> 2017/6/28 15:27:54 PENG Yi, BU Qiang 400true ［Abstract］　American Diabetes Association and World Health Organization recommend hemoglobin(HbA1c) as one of the diagnostic standards for diabetes. The testing standardization for HbA1c and diagnostic cut-off points of pre-diabetes and diabetes remain controversial. The testing standardization for HbA1c and its clinical application on diagnosing diabetes are reviewed in this paper.]]> 2017/6/28 15:27:54 ZHOU Xiao-na, ZHU Xing-cheng, YANG Yong-lin 399true ［Abstract］　Stromal cell derived factor-1(SDF-1) belongs to the family of chemokines.SDF-1/CXCR4 axis plays an important role in mesenchymal stem cell homing to chronic wound healing and it can be a potential treatment for the diabetic patients with chronic wounds including diabetic foot ulcer, venous ulcer, arterial ulcer and stress ulcer. This review summarizes the research progress in the mechanism and signaling pathways of SDF-1/CXCR4 axis in regulation of mesenchymal stem cell.]]> 2017/6/28 15:27:54 ZHANG Jie, XIANG Jie, QIN Ying-fen 398true ［Abstract］　Triple-receptor negative breast cancer(TNBC) is a kind of breast cancer whose expressions of estrogen receptor(ER), progesterone receptor(PR), and human epidermal growth factor receptor 2(HER2) are all negative.TNBC has special biological and pathological characteristics and poor prognosis. The progress of research on the ultrasonic imaging diagnosis of TNBC is reviewed in this paper.]]> 2017/6/28 15:27:54 HUANG Xiao-li, WANG Xiao-yan 397true ［Abstract］　Breast cancer is a common malignant tumor with high mortality. Long noncoding RNA HOX transcript antisense RNA(Lnc RNA HOTAIR) is relevant to the oncogenesis, progression, metastasis and prognosis of various human cancers. In this paper, we review the research progress of Lnc RNA HOTAIR in breast cancer.]]> 2017/6/5 17:27:11 DENG Yu-jie, PANG Wei-yi 396true ［Abstract］　Chemotherapeutic drugs applied to treating leukemia such as cyclophosphamide,gemcitabine, daunorubicin and so on can cause thrombocytopenia in varying degrees, leading to bleeding of the skin mucous membrane and the internal organs, and even the termination of chemotherapy and life threatening. At present platelet transfusion and platelet growth factors such as recombinant human interleukin-11(rhIL-11), recombinant human thrombopoietin(rhTPO) have been used clinically to treat thrombocytopenia associated with leukemia chemotherapy. In this paper, the pathogenesis of thrombocytopenia after chemotherapy, and the treatments of platelet transfusion and platelet growth factors are reviewed.]]> 2017/6/5 17:27:11 HU Xiao-liang, TAO Jie 395true ［Abstract］　Studies confirm that Icotinib is effective in the treatment of epidermal growth factor receptor（EGFR） mutations for the patients with advanced non-small- cell lung cancer（NSCLC）, and improves the curative effect of radiotherapy. A large number data of domestic studies show that Icotinib combined with radiotherapy can significantly improve the survival time for the patients, especially for the elderly patients or those with brain metastases. The combined therapy has less adverse reactions and improves the qualitiy of life, and will be an effective treatment for the patients with advanced NSCLC.]]> 2017/6/5 0:00:00 GUO Hong-yun, JIA Ya-sen, FENG Guo-sheng 394true ［Abstract］　Magnetic resonance imaging(MRI), with high resolution of soft tissue, multiplanar and multi-parameter imaging, has been widely used in the diagnosis of female pelvic diseases. The research progress of MRI in the diagnosis of endometrial polyps is reviewed in this paper.]]> 2017/6/5 17:27:11 LIU Ying, MA Long-bai 393true ［Abstract］　Renal cell carcinoma(RCC) is the second malignant tumors in the department of urology. The treatment of advanced RCC is limited, because it is not sensitive to radiotherapy and chemotherapy. Recently, targeted therapy has brought hope for the patients with RCC. Tumor targeted therapy mainly inhibits tumor angiogenesis and tumor cell proliferation. Tumor angiogenesis is influenced by many factors, and is regulated by many factors, like vascular endothelial growth factor(VEGF). Angiopoietin-2(Ang-2) has been shown to be a key regulator factor of angiogenesis. Clinical studies have confirmed that blocking VEGF has become an effective way to treat RCC. VEGF and Ang-2 have a synergistic effect on the regulation of angiogenesis. With the developments of these studies, Ang-2 can not only be used as a target for RCC treatment, but also be combined with VEGF in the treatment of RCC. The research progress of Ang-2 and VEGF in the treatment of RCC is reviewed in this paper.]]> 2017/6/5 0:00:00 WANG Jie, HAN Hui, QIN Zhen-zhen, et al 392true ［Abstract］　In recent years, the application of ultrasonography in diagnosis of lung diseases has become a hot research topic clinically. Lung ultrasound is radiation-free, inexpensive, convenient and bedside. There is a good correlation between it and high-resolution computed tomography(HRCT) and pulmonary function. The clinical application progress of lung ultrasound that is used to check the patients with interstitial lung disease(ILD) is reviewed in this paper.]]> 2017/6/5 17:27:11 HUANG Xiang-hong, TAN Yi 391true ［Abstract］　Rhegmatogenous retinal detachment（RRD） is a common and acute disease that can lead to blindness and RRD will severely affect the patients′ quality of life and work ability if they don′t get the correct diagnosis and treatment in time.The treatment of RRD is mainly through surgeries resently, including pneumatic retinopexy,scleral buckling,vitrectomy combined vitreous chamber filling silicone oil or gas.In recent years, these surgical approaches have been improved in some degree.In this paper, the progress of reseach on the surgical treatment of rhegmatogenous retinal detachment is reviewed.]]> 2017/6/9 0:00:00 CHEN Jie-hua, LI Min 390true ［Abstract］　In 2003, on the basis of classification of breast X-ray, the American College of Radiology(ACR) recommended that the Breast Imaging Reporting and Data Systems(BI-RADS) be the diagnostic method of breast tumors. The results of long-term practical applications around the world show that the BI-RADS classification is helpful to improve the diagnostic consistency among the doctors, and is helpful to improve the quality of data collection and monitoring results, and the quality of imaging diagnosis. With the progress of imaging technology and a better understanding of breast imaging in the diagnosis of breast tumors, in 2013, ACR in summing up the experience of the development of modern imaging technology and clinical practice, and on the basis of the updated BI-RADS, added some new terms, definitions and technologyies, especially on the ultrasonic part greatly extended.In this paper, the research progress of BI-RADS in diagnosis of benign and malignant breast tumors is reviewed.]]> 2017/6/9 8:58:44 WEI Cai-fen, LIANG Liu-ju 389true ［Abstract］　Fissure sealant called the anti-caries coating is a new type of oral medical polymer material developing in 1960s. When coated on the surface of teeth grooves, the material will form a barrier to seal the grooves. The barrier isolates the teeth from the damage caused by caries in the oral cavity. There is no obvious difference between the fissure sealant of permanent teeth and thesealant of deciduous teeth. When children are operated by sealing the deciduous teeth, they are too young to coordinate with the dentists. To achieve the better preventive effect on carious teeth, the short-term and easy operations are more suitable for the children. Dentists are very cautious of choosing the sealants when they are sealing the primary molars. The research progress of fissure sealants in sealing the primary molars is reviewed in this paper.]]> 2017/6/9 8:58:44 MENG Ke-yu, SHI Chun-mei 388true ［Abstract］　Total hip arthroplasty(THA) is one of the most successful surgical methods for the treatment of the patients with advanced hip joint disease, THA can significantly improve the function of the hip joint, correct the deformity and relieve the pain. It is very important to carry out the early,correct and effective rehabilitation exercises after THA. Many scholars advocate to perform the early full weight bearing exercise after the cementless THA, however there is not a specific standard time for the early full weight beariong exercise in the actual clinical practice. Many patients do not perform the early functional exercise and as a result the time of rehabilitation and functional recovery after THA is prolonged. To solve this problem, we review the research progress of early full weight bearing after uncemented THA in this paper.]]> 2017/6/9 8:58:44 ZHENG Dian-tao, YIN Dong 387true ［Abstract］　Mild cognitive impairment(MCI), a common cognitive impairment, is the clinical state between normal ageing and Alzheimer′s disease(AD). As a precursor phase of AD, positive MCI researches have important significance on retarding the further decline of cognitive function and development of AD. In this paper, we review the concept, diagnosis, classification, pathogenesis, risk factors and interventions of mild cognitive impairment.]]> 2017/6/9 8:58:44 HUANG Sheng-jin, ZHENG Li-ping 386true ［Abstract］　As a minimally invasive treatment, extracorporeal shock wave(ESW) is widely used in clinic. Encouragingly, it is applied more and more extensively in the field of orthopedics, especially in the treatment of nonunion, tennis elbow, scapulohumeral periarthritis, calcaneodynia and chronic lumbar strain. We summarize the physical property, the effect and mechanism of ESW in orthopedic diseases in this paper.]]> 2017/6/14 10:41:48 LIU Wen-hui, LI Fu-lin, YIN Dong 385true ［Abstract］　Perioperative stimulation can cause stress response. Moderate stress response is beneficial to the body, however excessive stress response can cause changes in the body′s internal environment, which may lead to high blood pressure, tachycardia, myocardial ischemia, arrhythmia and other adverse reactions of the cardiovascular system. The perioperative stress response and its prevention and treatment are reviewed in this paper.]]> 2017/6/14 10:41:48 YIN Shi-jie, LI Yong-lu 384true ［Abstract］　Currently, surgery and chemotherapy remain to be the primary therapeutic method for the patients with gastric cancer. For the patients undergoing surgery, the preoperative nutritional conditions directly affect their postoperative prognosis, overall survival and disease-specific survival rates. In this paper, we review the research progress of nutritional support treatment for the gastric cancer patients.]]> 2017/6/14 10:41:48 SU Tian-xiong, GUO Jian-sheng 383true ［Abstract］　Currently, lung cancers are the biggest threat to human health in all cancers, in which non-small cell lung cancer(NSCLC) accounts for about 75%～80% and 70% of the patients with NSCLC have missed the chance to receive the radical surgery when diagnosed. Radiation,chemotherapy and targeted therapy are the main therapies, but the prognosis is still poor. Therefore, improving the radiation sensitivity of NSCLC still needs to be solved. In this article，we review the research progress of radiotherapy sensitization in NSCLC.]]> 2017/6/14 10:41:48 LAI Xiang-li, GUO Hong-yun, FENG Guo-sheng 382true ［Abstract］　Simple superficial vein varicosity of lower limbs refers to the scope of pathological changes limited to the superficial vein of lower limbs, of which the most are the great saphenous vein. High ligation operation of stripping is the main treatment, however with the development of medical techniques, some novel surgical methods have achieved great success on the operation.In this paper, we review the progress of research on the treatment of great saphenous vein varicosity.]]> 2017/6/14 10:41:48 LI Nian, LIU Qiang, SHI Jian-jun 381true ［Abstract］　Gallbladder muddy stones are a comman disease. The pathogenesis of the disease involves a variety of factors, and the symptomatic patients need the proper treatments, including the traditional medical treatments, surgical treatments and endoscopic minimally invasive treatment. The last is a novel one and we review its progress of research on gallbladder muddy stones in this paper.]]> 2017/6/22 9:55:21 LUO Xian-ke, LU Xiu-ping, LU Zheng-feng, et al. 380true ［Abstract］　Spinal cord injury is one of the common and serious diseases in spinal surgery, and its treatment has been a worldwide tough problem. Secondary injury caused by spinal cord injury is more serious, and autophagy and apoptosis play an important role in the process of regulation. The research progress of the effects of therapeutic intervention on autophagy and apoptosis in spinal cord injury is reviewed in this paper.]]> 2017/6/22 9:55:21 GUI Yu-chang, XU Jian-wen 379true ［Abstract］　Tennis elbow is a common syndrome of over using the extensor tendons of the forearm. It is sometimes called lateral epicondylitis.The exact causes of lateral epicondylitis remain unclear. The management of tennis elbow includes conservative treatment and surgical therapy. Generally, the conservative treatment covers taking a rest and functional exercises, non-steroidal anti-inflammatory drugs, glucocorti-coid injection, botulinus toxin injections, autologous blood injections, ex-tracorporeal shock wave, eletric stimulation therapy, acupuncture therapy and laser therapy, in which extracorporeal shock wave shows a promising prospect in the treatment of tennis elbow. Surgical therapy is suitable for the intractable tennis elbow. In this paper,the pathogenesis, diagnosis and the current treatment of tennis elbow are reviewed.]]> 2017/6/22 9:55:21 LI Fu-lin, HUANG Yu, YIN Dong, et al. 378true ［Abstract］　Enterostomy is one of the common surgical procedures in colorectal cancer. Enterostomy changes the normal defecation, and brings great physical and mental suffering or discomfort to the patients, however, continuing care can help improve their quality of life. The tools of modern information technology used for continuing care include phoning, texting, QQ and WeChat. In order to provide the reference for promoting clinical application of the network information technology, we review the research progress of modern information technology used in enterostomy patients with continuing care in this paper.]]> 2017/6/22 9:55:21 ZHANG Xin, HUANG Lin-han, NA Wen-yan, et al. 377true ［Abstract］　The evaluation of imaging studies before the operation has significant clinical value. With the development of modern imaging technologies, the combination of different modalities will be prevail in colorectal cancer preoperative staging and is valuable in clinical practice. In this paper, the advances in image evaluation of colon carcinoma before the operation are reviewed.]]> 2017/6/22 9:55:21 NONG Li-hong, LU Bing-feng 376true ［Abstract］　The dysregulation of miroRNAs(miRNAs) is associated with many diseases. Evidences show that it also plays an important role in the occurrence of irritable bowel syndrome(IBS). Some special miRNAs may be both diagnostic and therapeutic tools for IBS. During the last several years, blood microvesicles(MV) have been found that they are pivotal physiological vehicles to deliver miRNAs in human beings. Thus, it is possible to use MV as vehicles to deliver miRNAs inhibitor vector(or miRNA precursor) in vivo in the future studies.]]> 2017/6/30 9:13:09 LIANG De-jiao, LIANG Lie-xin, ZHANG Fa-can 375true ［Abstract］　Human epicardial adipose tissue(EAT) is a kind of covering internal fat tissues on the surface of the heart and great vessels. It is not only a place where excessive energy storages, but also an endocrine organs. In recent years, the new progress of EAT has been made in cardiovascular diseases, atherosclerosis and metabolic syndrome. The clinical research progress of epicardial adipose tissue is reviewed in this paper.]]> 2017/6/30 9:13:09 LIU Wei-hua, PANG Zhen-yao 374true ［Abstract］　Portal vein thrombosis(PVT) refers to the thrombosis that happens in any part of the portal vein, including the main portal vein, superior mesenteric vein, inferior mesenteric vein and splenic vein. At present, PVT is the most common and serious complication in the patients with liver cirrhosis after splenectomy associated with devascularization, which can lead to abnormal hepatic blood inflow, portal vein hypertension aggravation, further liver function failure and even death. A comprehensive understanding of PVT is conducive to the early preoperative assessment of the risks and monitoring the occurrence of PVT. The new research progress of liver cirrhosis portal vein thrombosis after splenectomy is reviewed in this paper.]]> 2017/6/30 9:13:09 ZHANG Wen-xiang, XIE Qiang-qiang, LV Ting-ting, et al. 373true ［Abstract］　With the development of social economy and industrialization, deep tissue and soft tissue injuries caused by high energy damage such as muscle, fascia, skin and so on occur frequently. These injuries are often accompanied by different sizes of the wound and do not heal primarily. Vacuum sealing drainage(VSD) is so far the most effective method for treating skin and soft tissue defects. It can be applied in the whole process of the treatment. The relevant key points of VSD play an important role in the secondary skin grafting, because they can promote skin grafting survival and the early rehabilitation of the wound. We review the progress of vacuum sealing drainage in wound free skin grafting in this paper.]]> 2017/6/30 9:13:09 NONG Zhi-ning, WEI Jian-xun 372true ［Abstract］　Pancreaticoduodenectomy(PD) is one of the most traumatic procedures for abdominal surgery. The surgical approach should be improved because of the extensive excision scope, large surgical trauma, long-time operation, more postoperative complications and high mortality rate in the traditional PD. With the development of modern imaging technology and evidence-based medicine, some new characters and different viewpoints on PD appear. In consideration of the universality of PD in China, it is necessary to review the new techniques and new ideas of PD in this paper.]]> 2017/12/22 10:21:37 ZHANG Wen-tao, LIU Yu, MA Yan-bo 371true ［Abstract］　With the aging of population, the incidence of hip fracture in the elderly is increasing, which has become a social problem that affects the health of the elderly. Intertrochanteric fracture is a common clinical hip fracture for which there are a lot of current treatment methods. Artificial hip joint replacement is one of the selections of operation on the elderly with intertrochanteric fracture. However there are still some controversy points of view on choosing the prostheses clinically. The indications of two kinds of prostheses and the concept of their evolution, curative effects and complications in hip replacement for intertrochanteric fracture in the elderly are reviewed in this paper.]]> 2017/12/22 10:21:37 ZUO De-ling, YIN Dong 370true ［Abstract］　With the development of endoscopic technology, the diagnostic rate of early gastric cancer has been elevated. Early detection of gastric cancer will significantly improve the prognosis as well as survival rate of the patients. The advanced techniques such as narrow-band imaging, flexible spectral imaging color enhancement, I-scan, confocal laser endoscopy and blue laser imaging that are applied in early gastric cancer are reviewed in this paper.]]> 2017/12/22 10:21:37 LAI Chang-jiang, LIANG Lie-xin 369true ［Abstract］　Normally, there are more than 100 kinds of parasitic bacteria centered on the large intestine, and the quantity is over 100 trillion. They live in the intestinal tract and gather together, known as the “intestinal bacteria”. The intestinal bacteria are divided into “beneficial bacteria”, “harmful bacteria” and some groups of anaerobes. These microbes live in our guts and coexist peacefully in balance. Antibiotics play an important role in the treatment of bacterial infections or other infections caused by pathogenic microorganisms. Antibiotics kill not only the pathogenic microorganisms, but also some species of beneficial flora. Therefore, the intestinal microecological balance would be destroyed because of the abuse of antibiotics, which causes the dysbacteriosis. The research progress of the effects of antibiotics on the changes of intestinal flora is reviewed in this paper.]]> 2017/12/22 10:21:37 CHEN Hong-bing, TAN Yi 368true ［Abstract］　Osteonecrosis of femoral head(ONFH) is a progressive damage function of the hip disease. Early-stage treatment of ONFH will alleviate the patients′ pain and improve their quality of life. Bone marrow mesenchymal stem cells(BMSCs) can promote osteogenesis and angiogenesis of blood vessels of local ONFH in a suitable microenvironment, relieve or prevent ONFH further deterioration.In recent years, BMSCs has achieved a satisfactory curative effect on the treatment of the femoral head necrosis. The research progress in the treatment of ONFH with BMSCs is reviewed in this paper to provide the guidance of BMSCs for clinical treatments.]]> 2017/11/28 17:12:43 HUANG Si-cheng, LI Hong-yu 367true ［Abstract］　Radiation therapy is an important method for the comprehensive treatment of tumors, however resistance has been becoming an increasingly prominent problem, because radiation therapy is applied more and more extensively in clinics. Low radiation sensitivity is a main problem affecting the efficacy of radiotherapy for cancer patients. Cyclooxygenase-2 has been confirmed to participate in the occurrence and development of tumors. Recent studies indicat that the expression of cyclooxygenase-2 can lead to radiation resistance. The effects and mechanisms of the expression of cyclooxygenase-2 in the production of radiation resistance is reviewed in this paper.]]> 2017/11/28 17:12:43 LIU Shan, ZHAO Li, SHEN Hong-mei 366true ［Abstract］　Embryo implantation is the key to successful pregnancy after in vitro fertilization and embryo transfer. The cause of repeated embryo implantation failure is complicated, and difficult to treat, which is a research hotspot of reproductive medicine. Studies have shown that abnormal uterine contraction is one of the causes leading to the embryo implantation failure. If some depressants of uterine contraction are applied before and after embryo transfer, the inhibition of uterine contraction may be conducive to improving endometrial receptivity and the pregnancy outcome. In this paper, the progress of research on association between uterine contraction and embryo implantation and depressants of uterine contraction is reviewed.]]> 2017/11/28 17:12:43 ZHANG Yi-sheng, HE Bing 365true ［Abstract］　Ketogenic diet is a novel non-drug therapy for refactory epilepsy. The research progress of ketogenic diet in the treatment of epilepsy is reviewed in this paper.]]> 2017/11/28 17:12:43 WANG Liu-qing, ZHAO Wei-wei, ZHANG Shou-cheng 364true ［Abstract］　The treatment of osteonecrosis of the femoral head(ONFH) has always been being a major problem in department of orthopedics, and total hip arthroplasty(THA) is the best treatment in the advanced stage. ONFH has shown a younger trend in recent years, and the young adults who have longer life spans and high demand for joint mobility will face multiple repairing sugeries and heavier physical and economic burden. Hip preserving treatment is still the preferred treatment. The correct choice of the right hip therapy can delay the progression of the disease, reduce pain and the need for joint replacement in the patients with ONFH.]]> 2017/11/28 17:12:43 WU Yi-hua, ZHAO You, LU Chang-wei 363true ［Abstract］　Sepsis is one of the main causes of critical illness globally, which is faced with the challenges of improving the successful rescue, shortening the length of ICU stay, reducing the mortality and hospitalization expenses and these may be done by early interventing or blocking a series of inflammatory cascade reaction in the septic patients. These early treatments have important social and economic benefits for the patinents. So far, many studies have found that a blood perfusion joint continuous vein-vein hemofiltration treatment can effectively remove the inflammatory mediators, adjust the cell immunity and improve the internal environment of the body, which will bring a new hope for the treatment of sepsis. The progress of research on blood perfusion jiont continuous vein-vein hemofiltration for sepsis is reviewed in this paper.]]> 2017/10/26 8:15:41 PANG Jing, SHI Hui-rong, JIANG Ling-yu, et al. 362true ［Abstract］　Imitation of bioelectricity electrical stimulation is used in the treatment of gynecology and obstetrics in recent years. It improves the tissue microcirculation and the receptivity of endometrial and promotes the recovery of organic structures and biological function through different frequencies of current stimulation to increase and improve the blood circulation and nutrition of pelvic floor, vagina, endometrium and uterus muscles. It is a noninvasive, safe, convenient, well compliant and new treatment. In this paper, the research progress of imitation of bioelectricity electrical stimulation in the field of gynecology and obstetrics is reviewed.]]> 2017/10/26 8:15:41 ZHANG Cui-lan, LAN Xiao-mei 361true ［Abstract］　Many studies show that vertebral artery stent implantation can improve the blood flow in the patients with vertebral artery stenosis, but its restenosis rate is relatively high. Its long-term effect of prevention is not necessarily better than the best medication alone. In this paper, the research progress of vertebral artery stent implantation in treatment of vertebral artery atherosclerotic stenosis is reviewed.]]> 2017/10/26 8:15:41 LAN Xiang-lin, WANG Qia-ru 360true ［Abstract］　Diabetic nephropathy is one of the main microvascular complications of diabetes. The pathogenesis of diabetic nephropathy is not yet completely clear. Some multiple mechanisms contributing to the pathogenesis of diabetic nephropathy, including sugar metabolism disorders, inflammatory reaction, genetic susceptibility, hemodynamic changes and cytokines. Its clinical treatments including the control of diet, plasma glucose, blood pressure and lipid should be done to delay disease progression and to improve the quality of life. The research progress in the pathogenesis and treatment of diabetic nephropathy is reviewed in this paper.]]> 2017/10/26 8:15:41 YU Xiao-bo, YU Yong-zhuang 359true ［Abstract］　Early education is a measure for promoting the intelligence and physical development in infants, whose content and mode of implementation is one of the hot issues. Over the years, domestic and foreign experts have made the constant explorations of early education in infants. Despite of its various forms of researches, the results are that there is a positive effect on the infants′ growth and development. This article focuses on the research progress of early education in infants.]]> 2017/10/26 8:15:41 ZHANG Jing, FANG Yu 358true ［Abstract］　As a part of comfortable personalized health care, labor analgesia is becoming more and more demanding. Spinal canal anesthesia is the most recommended way of releasing labor pain. With the rapid development of modern medicine, the advanced way of anesthesia and analgesic adjuvants emerge. Among them, patient self-controlled epidural analgesia and automation technology are significant to improve the capability of the management of labor pain, which redefines the dosing strategy of labor analgesia. In this paper, we review the research progress of spinal canal anesthesia on labor pain.]]> 2018/9/30 16:15:19 ZHANG Yan-peng, YANG Bao-zhong 357true ［Abstract］　The intestinal tract is the digestion organ of human body, which has a barrier to the intestinal bacteria and their toxins. The intestinal mucosas are most vulnerable to stresses, such as trauma, infection, shock and surgery. If the intestinal mucosas are damaged, they will cause a series of pathophysiological changes, even leading to the occurrence of systemic inflammatory response syndrome(SIRS) and multi-organ dysfunction syndrome(MODS) which would result in an unbearable outcome for the patients. Early warning of the intestinal mucosal barrier function is very important for preventing the clinical adverse events of the intestinal mucosal barrier function.At present, domestic and foreign scholars have reported many markers related to the damage of intestinal mucosal barrier and hope that they can be used to predict severity and prognosis in the patients clinically. In this paper, we review the research progress of D-lactic acid and I-FABP in the impaired intestinal barrier function.]]> 2018/9/30 16:15:19 CHENG Yuan, XU Peng-yuan 356true ［Abstract］　Rotator cuff injury is a clinical common disease, especially in the elderly and athletes, and it′s very hard to cure. With the development of science and technology, great progress of medical treatment has been made in recent years, but there is still a certain failure rate in clinics. So the treatment of rotator cuff injury turns into an important issue. Various treatments and repair methods for the patients with rotator cuff injury have being emerging constantly, which improves the success rate of repair and makes the patients have more treatment options. This paper summarizes the treatment and repair methods of rotator cuff injury.]]> 2018/9/30 16:15:19 YANG Yong, ZHANG Jian-lin 355true ［Abstract］　Biochemical liver function is closely correlated with the progression of hepatitis C. There is also a correlation between different biochemical liver function indicators. To study the relationship among multiple indicators will be helpful to the diagnosis and treatment of hepatitis C. The advances in research on the correlation between liver function index and hepatitis C is reviewed in this paper.]]> 2018/9/30 16:15:19 LIU Wen-jun, ZHANG Min, LU Xiao-xu, et al. 354true ［Abstract］　The nasal type of extranodal NK/T-cell lymphoma(ENKTCL) is a kind of malignant lymphomas closely associated with Epstein-Barr virus(EBV) infection. The features of ENKTCL are aggressive strongly, poor response to chemotherapy, easy to relapse and poor prognosis. microRNA(miRNA) is about 20～24 nt noncoding RNA, and the dysregulation of miRNA can lead to the occurrence of many tumors and is closely related to the pathogenesis of ENKTCL. Effective markers are crucial in the diagnosis, treatment and prognostic evaluation of ENKTCL. We review the roles of miRNA in the development of ENKTCL in this paper.]]> 2018/8/24 16:25:15 CHEN Hui-ling, MO Xiang-lan 353true ［Abstract］　Adiponectin(APN) is a highly adipocyte-specific secretory adipokine by white adipose tissue. APN affects the regulation of lipid and energy metabolism, glucose metabolism and cardiovascular function. APN has a variety of functions including anti-flammatory, anti-atherosclerotic, insulin sensitization and so on. A large number of studies indicate that APN plays an important role in occurrence and development of acute pancreatitis. In this paper, we review the relationship between adiponectin and pancreatitis.]]> 2018/8/24 16:25:15 CAO Cong, HUANG Zan-song 352true ［Abstract］　With the rapid development of laparoscopic equipments and techniques and the continuous accumulation of operation experience, laparoscopic surgery is safe and effective for low rectal cancer. It has advantages of clear vision, less trauma and physiological disturbance and quick recovery after operation. To explore the efficacy of laparoscopic surgery for low rectal cancer and improve the anal function and quality of life of the patients, we review the research progress of laparoscopic radical resection for low rectal cancer in this paper.]]> 2018/8/24 16:25:15 XIE Gui-sheng, DONG Bao-guo 351true ［Abstract］　The transmission of human immunodeficiency virus(HIV) from maters to infants is the main source of infants infected with HIV virus. The prevention and control of the maternal-neonatal transmission is a complicated societal program which needs the efforts of the related people including different departments, social organizations and individuals to work together to reduce the HIV infection rate in infants. In this paper, we summarize the comprehensive measures in different aspects, such as the situation in pregnant women who infected with HIV, high risk groups, social organizations, the managements of floating population and medical treatment.]]> 2018/8/24 16:25:15 MO Zeng-luan, TIAN Mao 350true ［Abstract］　Three-dimensional finite element analysis is one of the most important research methods on orthopaedic biomechanics and only this analysis method can closely reveal the real research on physiology, pathology, disease mechanism of hip joint because of its complex anatomic structure and unique disease. In addition, the clinical diagnosis, treatment and prevention, as well as the design, production evaluation of surgical instruments researched by the three-dimensional finite element analysis have obtained tremendous development. In this paper, we review the advances in application of three-dimensional finite element analysis on measuring biomechanics of hip joint.]]> 2018/8/24 16:25:15 PAN Rong-gui, PENG Cong-cong, TENG Jü-zan 349true ［Abstract］　Since 1980s, autologous hematopoietic stem cells transplantation(auto-HSCT) has developed as one of the main therapies for hundreds of thousands of patients with acute myeloid leukemia(AML), for whom HLA-matched related donor can not be found and allogeneic hematopoietic stem cell transplantation was not done. This article aims at reviewing the progress of auto-HSCT in treating the AML patients with low, intermediate and high risk factors. and the refractory or recurrent AML, and reviewing the strategy about decreasing the relapse of auto-HSCT therapy.]]> 2018/7/30 16:15:15 CHEN Yong-sheng, HUANG Qin, YIN Xiao-lin 348true ［Abstract］　Sepsis and septic shock are the major problems in acute and severe medical care. The incidence of sepsis is increasing as the population ages and the medical-related invasive procedures increase. At present, the definition of sepsis is not only confined to infections and systemic inflammatory response, but accurately stressed the body′s response to infections resulting in loss of organ dysfunction, whose pathological process involves the aspects of neuroendocrine, metabolic disorders, coagulation abnormalities and nonimmunological diseases. Hyperglycemia is common in the patients with sepsis and septic shock, whose prognoses are usually bad if high blood sugar is not effectively controlled.]]> 2018/7/30 16:15:15 WEI Li-hong, ZHANG Jie 347true ［Abstract］　Central venous catheters（CVCs） are extensively used in the patients with severe diseases treated in Intensive Care Units. An important complication of CVCs is the development of catheter-related thrombosis(CRT) which becomes symptomatic in approximately 5% of the patients.The epidemiological characteristics, risk factors, symptoms, diagnosis, prevention and treatment of CRT are reviewed in this paper.]]> 2018/7/30 16:15:15 DENG Da-zhi, HUANG Xiang-hong 346true ［Abstract］　Neoadjuvant chemotherapy（NCT） is a systemic chemotherapy before local treatment of breast cancer. Clinical studies have shown that NCTs have a certain effect on improving breast-conserving rate, clinical downstaging, guiding the choice of chemotherapy regimens，preventing distant metastasis and improving the pathological complete remission rate. However, there are also many problems remaining to be solved. In this paper, we review the research progress of neoadjuvant chemotherapy for breast cancer.]]> 2018/7/30 16:15:15 TANG Jian-zhou, HE Jun 345true ［Abstract］　The application of Traditional Chinese Medicine(TCM) constitution identification in diagnosis and treatment of knee osteoarthritis(KOA) has been widely reported. Studies show that the constitution of the patients with KOA is mostly distributed in yang deficiency, qi deficiency and qi depression, and phlegm dampness results in a high incidence of male KOA. In women, qi deficiency, qi depression and phlegm wet quality result in a high incidence of constitution. On the basis of these TCM theories, the targeted TCM treatments have achieved good results. In this paper, we review the application status of TCM constitution identification in diagnosis and treatment of KOA.]]> 2018/7/30 16:15:15 ZHOU Jian-fei, HONG Ding-gang 344true ［Abstract］　Drug eruptions are the most common adverse reactions to drugs. Severe drug eruptions, including Stevens-Johnson syndrome(SJS), toxic epidermal necrolysis(TEN), drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome(DRESS/DIHS) and acute generalized exanthematous pustulosis(AGEP), can cause high mortality. Recently, substantial progress has been made in understanding the relationship between human leukocyte antigen(HLA) and severe drug eruptions. These findings will facilitate the establishment of testing methods for predicting potential genetic susceptibility to drug eruptions in individuals. In this paper, we review the relationship between severe drug eruptions and specific HLA alleles.]]> 2018/6/29 17:08:36 XIANG Yi-kui, YAN Yan, WANG Bao-xi 343true ［Abstract］　Hepatitis B virus(HBV) infection has been a high incidence in China. HBV related acute liver injury is the main category of liver failure in China. T cells are the main components of the adaptive immune system, and play an indispensable role in the pathogenesis of HBV related acute liver injury. Because of the high heterogeneity of T cells and the complex effects of HBV infection on the host immune system in natural history, we currentlyl do not know thoroughly about the pathological process of HBV infection and T cell immunity involving in acute liver injury. In this paper, we discuss the changes and possible mechanisms of the two factors involving in acute liver injury from the biological process of HBV infection and the functional characteristics of T lymphocyte subsets.]]> 2018/6/29 17:08:36 MAO De-wen, WANG Ming-gang 342true ［Abstract］　The development of optical coherence tomography(OCT) has changed the clinical management models of many ophthalmic diseases by improving understanding of pathogenesis of the diseases, thereby improving the monitoring of disease progression and helping to quantify the treatment of ophthalmic diseases. OCT provides information to improve our understanding of glaucoma greatly. The research progress of OCT in diagnosis and treatment of glaucoma is reviewed in this paper.]]> 2018/6/29 17:08:36 LIANG Zhu-nian, MENG Xue-fang, ZENG Si-ming 341true ［Abstract］　The operations of spinal fractures are often delayed because of the increased risk of paraplegia in some patients with spinal cord injury and a critical condition in the patients with thoracic injuries and spinal fractures. These patients can not exercise early and have the disadvantage of respiratory function recovery due to the spinal fractures. Therefore, the patients often have bed-ridden complications(pneumonia, atelectasis, etc) and their conditions are further aggravated by these complications. The two kinds of injuries interact with each other, and the choice of therapeutic regimens is still in dispute. In this paper, we review the research progress in the treatment of thoracic injuries and spinal fractures.]]> 2018/6/29 17:08:36 MA Jun, XIA Hong, ZHAO Lin 340true ［Abstract］　Sepsis is a common critical illness in intensive care units, with high mortality, poor prognosis and difficulty in diagnosis and treatment. Interleukin-18(IL-18) is a pleiotropic proinflammatory cytokine that is highly expressed in sepsis and may be involved in the pathogenesis of sepsis through an inflammatory cascade.In this paper, we review the structure, biological characteristics, gene polymorphism and the mechanism of IL-18 in sepsis.]]> 2018/5/30 8:21:23 HUANG Yu-qing, LIAO Pin-hu 339true ［Abstract］　Statins have the actions of lipid-lowering, reversing atherosclerosis plaque stabilization, anti-inflammatory, anti-oxidation, antithrombotic and improving endothelial function, and are widely used in the prevention and treatment of ischemic cerebral apoplexy. The research progress of the application of statins in prevention of ischemic stroke and the non-lipid-lowering action of statins are reviewed in this paper.]]> 2018/5/30 8:21:23 WANG Ying-ying, JIANG Ya-bin 338true ［Abstract］　Group B streptococci(GBS) are the main pathogens of infections during perinatal period which can cause neonatal pneumonia, sepsis, meningitis and death, and pyelonephritis, premature infant, premature rupture of membranes, and chorioamnionitis endometritis. Newborn babies survived after infections may have severe neurological sequelae, including hydrocephalus, mental retardation, microcephaly and deafness. The effects of GBS on mothers and their fetuses, the detection methods, the treatment and prevention of group B streptococcus infections are reviewed in this paper to make clinical doctors pay more attention on group B streptococcus infections and to reduce the occurrence of adverse pregnancy outcomes.]]> 2018/5/30 8:21:23 WEI Yan-fen, ZHANG Shan-shan, LIAO Shao-xia, et al. 337true ［Abstract］　Alzheimer′s disease(AD) is a common neurodegenerative disorder, and inflammatory immune response plays an important role in the pathogenesis of AD. Ghrelin has been widely studied in recent years, and becomes a research hotspot. The research progress of inflammatory reaction and its control methods related to the pathogenesis of AD inflammation Ghrelin, Toll-like receptors and inflammation factors are reviewed in this paper.]]> 2018/5/30 8:21:23 HUANG Dong-ming, HU Cai-you 336true ［Abstract］　As a common independently recurrent disease of dizziness, vestibular migraine(VM) has been becoming one of the hotspots of clinical research. VM is characterized as repeated episodes of recurrent migraine and dizziness usually companied with photophobia and phonophobia, nausea and vomiting. Researches and theories about its pathogenesis, electrophysiology, radiography, and diagnosis and treatment are gradually increased. Some are similar and some are controversial, and there is no a uniform research conclusion for the disease. We review the research progress of VM in this paper.]]> 2018/5/30 8:21:23 YUAN Hong, LI Hai-yan, LIANG Jian-ping 335true ［Abstract］　Pancreatic tumors(PNETs) derived from pluripotent neuroendocrine pancreas stem cells are called islet cell tumor. PNETs are rare and unusual in clinical practice, whose incidence rate is about 4 to 5 ppm of the normal population. Surgery treatment has a good prognosis for the patients with PNETs. However, misdiagnosis and missed diagnosis of PNETs are likely to occur because of its type diversity and symptom complexity. Therefore, early and accurate diagnosis is very important for an effective treatment of PNETs. This paper is intended to systematically summarize the current progress in treatments of pancreatic neuroendocrine tumors.]]> 2018/4/27 7:59:26 TANG Zhen-yong, TANG Yun-tian 334true ［Abstract］　‘Placenta previa’ and ‘uterine rupture’ are the common serious complications of pregnancy after cesarean section during perinatal period. The standardized inspection can predict the related risks as early as possible, and provide favorable information for the delivery. Gradually refined perinatal management can improve the success rate of vaginal delivery after cesarean section, and reduce the incidence of emergency surgery and the related complications, and therefore improves the prognosis of the mothers and infants.]]> 2018/4/27 7:59:26 WU Huan-yu, ZHANG Xiu-guo 333true ［Abstract］　Bone mineral density(BMD) is a reflection of the level of bone mineral deposition, and is an important indicator to evaluate the growth and development of children′s nutritional status and bone health. This review summarizes the research progress in application of ultrasonic bone mineral density measurement to evaluate neonatal bone development to provide scientific basis for promoting the healthy development of children′s bone and preventing bone diseases.]]> 2018/4/27 7:59:26 HONG Mei, LU Ming-xu, HUANG Lin, et al. 332true ［Abstract］　The incidence of chronic kidney disease(CKD) is increasing globally year by year, and CKD has become a global public health problem. Researches of overseas and domestic scholars indicate that the patients with CKD have higher risk of cognitive impairment(CI). CI is a transitional phase between healthy aging and dementia, with a low rate of early diagnosis and poor prognosis. It gives the family and society a heavy burden. We review the research progress of cognitive impairment in the patients with CKD in this paper.]]> 2018/4/27 7:59:26 GAN Wen-qian, WANG Jie 331true ［Abstract］　Acute liver injury induced by sepsis is one of the manifestations of sepsis-induced multiple organ dysfunction syndrome. It plays an important role in the development of sepsis, which often indicates the severity of the illness. Improving liver function helps to improve the patients′ prognosis.In this paper, we review the current researches about the incidence,clinical manifestations, pathogenesis and treatment measures of sepsis-induced liver injury.]]> 2018/3/28 17:03:21 SUN Ning, LUAN Zheng-gang 330true ［Abstract］　Cholecystolithiasis complicated with choledocholithiasis is one of the common clinical diseases and is a serious threat to human physical and mental health. In the past, open surgery was its main treatment with characteristics of a large trauma, high incidence of complications and slow recovery. With the continuous development of minimally invasive surgery, surgical therapies also enrich the way of treatment. In recent years, through the cystic duct approach three mirrors(laparoscopy, choledochoscopy and duodenoscopy) combined with the common bile duct exploration and retention of endoscopic nasobiliary drainage gradually applies to the patients in clinics, as a new treatment. In this paper, we summarize the operation scopes(indications, contraindications), technical points, advantages and disadvantages of the surgery to provide a reliable reference for clinicians.]]> 2018/3/28 17:03:21 HUO Jun-kai, LI Kai-hua, LIU Hong 329true ［Abstract］　Tanshinone ⅡA, one of the lipid-soluble active ingredients of Traditional Chinese Medicine Salvia Miltiorrhiza, exhibits antibacterial and anti-tumor actions, and cardiovascular and liver-protection effects. Recent studies have shown that tanshinone ⅡA has protective effects on renal injuries resulted from different causes. In this paper,we review the research progress of tanshinone ⅡA in treatment of kidney injury.]]> 2018/3/28 17:03:21 CHEN Xiao-yu, XI Jia-xi, YE Dong-mei 328true ［Abstract］　At present, bone transplantation is an important method for treatment of various causes of bone defects. How to accelerate bone healing and reduce complications remains a thorny problem, also an urgent and unresolved issue. The clinical application of autogenous bone graft and bone allograft, and the research progress of autogenous bone graft combined with allogeneic bone transplantation are reviewed in this paper, and the advantages and the feasibility of the combined bone graft are expounded.]]> 2018/3/28 17:03:21 CHEN Xiong, YIN Dong 327true ［Abstract］　Osteosarcoma is the most common malignant bone tumor of clinical orthopedic tumors. It is derived from mesenchymal tissue and mainly consists of spindle fibroblasts and osteoblasts, and predominates in children. The overall treatment of osteosarcoma is difficult. With the advent of neoadjuvant chemotherapy and postoperative adjuvant chemotherapy, disease-free survival rate and prognosis have been greatly improved. However, the toxic and side effects of osteosarcoma chemotherapy, including myelosuppression, nausea, vomiting, hair loss, mucosal inflammation, loss of fertility and incidental allergic reactions, have caused physical and psychological damage to the patients. Simultaneously, Osteosarcoma resistance to chemical drugs and the emergence of resistant osteosarcoma cells make the treatment of osteosarcoma less effective than current chemotherapy regimens. In this paper, we review the chemotherapy of osteosarcoma to further illustrate the status and research progress of osteosarcoma chemotherapy.]]> 2018/3/28 17:03:21 LIU Huai-hao, LIANG Zhen, LIANG Pei-jie, et al. 326true ［Abstract］　More and more evidence shows that short-chain fatty acids play an important role in the intestinal energy supply, the maintaining of intestinal mucosal barrier, the regulation of intestinal hypersensitivity and motility, the immune regulation and anti-tumor effect. Clarifying the relationship between the physiological function of short-chain fatty acids and some intestinal diseases as well as the related mechanisms is significant for the prevention and treatment of these intestinal diseases. The physiological function of short-chain fatty acids in the intestine is reviewed in this paper.]]> 2018/3/2 17:10:11 MENG Dan-li, LIANG Lie-xin, SONG Huai-yu 325true ［Abstract］　Colorectal cancer is one of the common malignant tumors in the digestive tract. In recent years, the incidence and mortality of colorectal cancer have been increasing. How to develop targeted treatments for the pathogenesis of colorectal cancer, and how to improve the prognosis of the disease are a problem that needs to be solved urgently. In this paper, we review the clinical treatment of colorectal cancer at home and abroad.]]> 2018/3/2 17:10:11 WEI Jin-lei, ZHANG Sen 324true ［Abstract］　There is not unified diagnostic standard of athletic heart at present in China. This paper summarizes and analyzes the diagnostic status, advantages and disadvantages, and the research progress of athletic heart in China over the past decade. The authors puts forward that we should unify the athletic heart definition, perfect the epidemiological investigation and develop the multicenter study in China as soon as possible. It is necessary that sports physicians, clinicians and the relevant experts should work together to establish the athletic heart diagnostic standard suiting for China.]]> 2018/3/2 17:10:12 MO Yi, WEI Jun 323true ［Abstract］　In recent years, the deceleration capacity of rate(DC) detection was found as a brand new detection which based on the dynamic electrocardiogram. It is also a latest noninvasive electrocardiograph technique which can screen and predict sudden-death for the population at high risk. The DC detection has the characters of high sensitivity and specificity and can quantitatively analyze the intensities of nervi vagus action. At present, it has application value in judging the degree of autonomic nerve damage, the risk stratification and the screening and early warning of sudden-death in high-risk patients in research of angiocardiopathy. The changes of DC have beeen found to be related to blood glucose control in the patient with diabetes mellitus, however whether DC can be a new reference index to diagnose diabetic cardiac autonomic neuropathy(DCAN）is debatable. The progress of clinical application research on deceleration capacity of rate detection is reviewed in this paper.]]> 2018/3/2 17:10:12 TANG Wen-hong, ZHANG Qin 322true ［Abstract］　Colorectal cancer(CRC) is one of the most common gastrointestinal malignant tumors, and the pathogenesis of it has not been fully elucidated. Autophagy is a significant pathway for metabolism and homeostasis in eukaryotic cells including human cells, which is probably correlated with the development and progression of tumors. In recent years, various studies have shown the association between autophagy and CRC. Autophagy related gene(ATG) may play an important role in the pathogenesis of CRC by regulating autophagy. In addition, autophagy may also have potential value for the therapy of CRC.]]> 2018/1/26 9:57:02 KANG Yi-kun, DONG Li, GAO Tian-bo, et al. 321true ［Abstract］　Signal transducers and activators of transcription 1(STAT1) regulates and involves in the development, differentiation, apoptosis and expression of breast cancer cells when being activated. STAT1 plays a regulating motivating role in the subtype of the breast cancer tissue. The transcription of STAT1 promotes the development of breast cancer cells, and suppresses the angiogenesis and metastasis of the carcinoma cells, which creates a new prospect of diagnosing and treating breast cancer.]]> 2018/1/26 9:57:02 LI Jie-hua, SONG Xiao-wei, WEI Tian-fu, et al. 320true ［Abstract］　Breast cancer and cardiovascular diseases are common diseases in women. It is reported that cardiovascular diseases are the main cause of death in the patients with postmenopausal breast cancer. Potential cardiovascular toxicity and cardiovascular events have become common health risks for cancer survivors. For this reason, a burgeoning interdiscipline, oncocardiology, comes into being.Cardiac protection of breast cancer patients should be considered in the whole course of treatment. However, the current domestic surgeons and oncologists do not pay enough attention to the cardiac damage in the cancer patients′treatment. It is necessary to strengthen the propaganda and education of breast oncocardiology. In this paper, we introduce the significance of establishment of breast oncocardiology and the multidisciplinary collaboration.]]> 2018/1/26 9:57:02 LI Hao, KONG Ling-quan, WU Kai-nan 319true ［Abstract］　Diabetic kidney disease(DKD), one of the most common microvascular complications of diabetes, is the leading cause of end-stage renal disease(ESRD) and death. The pathogenesis of DKD is not yet clear, but poorly controlled frequent high blood glucose leads to occurrence and development of DKD. Glycolated hemoglobin(HbA1c) is the “gold standard” that reflects the control of blood glucose in diabetic patients. HbA1c is not only likely to be an independent predictor of DKD, but also plays an important role in early diagnosis and treatment of DKD. Well-controlled HbA1c is an important factor affecting the progress and prognosis of DKD.]]> 2018/1/26 9:57:02 WU Xiao-cong, WU Ge 318true ［Abstract］　In this paper, the concept of rapid detection in drinking water sanitation supervision and its application significance, configuration and usage of the rapid detection equipments, the main existing problems and their countermeasures are reviewed.]]> 2018/1/26 9:57:02 PAN Da-yan, TAN Yi 317true ［Abstract］　Chronic lymphocytic leukemia（CLL） is one of the most common B cell malignancies in western countries. Despite the lack of accurate epidemiological data in China, the incidence of CLL is increasing with aging of population and the improvement of diagnostic level. It is characterized by the accumulation of mature B lymphocytes in bone marrow, lymph nodes, blood, spleen, liver and other organs. Long-term progression-free survival(PFS) can be achieved in some CLL patients after traditional immunochemotherapy, but the prognosis of the patients with recurrent/refractory and high risk cytogenetics is still unfavourable. The emerging new drugs in recent years can improve the prognosis of these patients. The research progress of two B-cell receptor signaling pathway inhibitors, ibrutinib and idelalisib, in treatment of CLL is reviewed in this paper.]]> 2018/12/29 16:55:29 GAO Dan, TAO Jie 316true ［Abstract］　As a family of endogenous and non-coding small RNAs, microRNAs are known to play a key role in regulating a variety of cellular processes in the post transcription that consist of proliferation,differentiation, apoptosis and immune response. microRNA146a(miR146a) is the first microRNA which was found as the regulator of immunity in mammalian. Concerning its abnormal expression in autoimmune diseases, miR146a has been paid more attention. Understanding the mechanism of miR146a will be helpful to the diagnosis and treatment of autoimmune diseases. In this paper, we review the research advances of miR146a in autoimmune diseases.]]> 2018/12/29 16:55:29 SHI Yu-hong, REN Ya-fei, JIANG Ya-nian, et al. 315true ［Abstract］　Hysteroscopy can be performed in the outpatient department of gynecology,which is a common, safe, feasible, and accurate procedure. However, a major obstacle to its successful implementation as a commonplace procedure is pain management. Transcutaneous electric nervous stimulation is a nonpharmacologic pain-relieving method based on the delivery of pulsed electrical currents through the skin. In this paper, we review the research progress of transcutaneous electric nervous stimulation in pain management after hysteroscopy.]]> 2018/12/29 16:55:29 XU Li-li, YANG Liu 314true ［Abstract］　Venous thromboembolism(VTE) is one of the common complications after gynecological surgery. VTE mainly includes deep venous thrombosis(DVT) and pulmonary thromboembolism(PTE). DVT is caused by the thrombogenesis of red blood cells, platelets and fibrous protein which obstructs the venous backflow leading to inflammatory changes in the wall of the vein. PTE is caused by the caducous blood clots of DVT that runs with the blood to the lungs. Because DVT and PTE are the venous thromboembolic disease process in two stages, the prevention of DVT and PTE is very important for preventing the rapid onset of PTE and high mortality rate of the postoperative complications. The changes of female hormones and the blood concentration and lipid metabolism disorders make venous thromboembolism more likely to occur during pregnancy. Once the pulmonary vessels were blocked, the patients′life would be threatened severely. To find a more effective way to prevent postoperative venous thrombosis in gynecology,we review the prevention and treatment of deep venous thrombosis after gynecological surgery in this paper.]]> 2018/12/29 16:55:29 JIANG Zhi-feng, CHEN Chang-yi 313true ［Abstract］　Non-alcoholic fatty liver disease(NAFLD) is a metabolic stress liver injury which is closely related to insulin resistance(IR) and genetic susceptibility. It is related to the clinical and pathological changes of obesity, type 2 diabetes, hypertension and dyslipidemia.Some cases may advance to liver fibrosis, liver cirrhosis, even attenuation of liver function, and hepatocellular carcinoma.Therefore, the early quantitative diagnosis of nonalcoholic fatty liver disease by non-invasive method is of great significance for clinical intervention.In this paper, the current research status and progress of ultrasound, computed tomography(CT) and magnetic resonance imaging(MRI) in the qualitative and quantitative diagnosis of fat are reviewed.]]> 2018/12/29 16:55:29 CHEN Song, HUANG Ze-he 312true ［Abstract］　The stress reaction caused by childbirth pain has a great influence on the physiology and psychology of both mothers and their babies. At the same time, it also causes the changes of immune functions in them. Labor analgesia brings good news to the expectant women. The impact of labor analgesia on maternal and infant immune functions is reviewed in this paper to provide the theoretical support for labor analgesia to ensure the safety of the mothers and their babies.]]> 2018/11/22 14:41:34 CHEN Shu-xia, YANG Bao-zhong 311true ［Abstract］　Height is influenced by genetic and environmental factors. Medical studies have confirmed that genetic factors have a greater impact on height development. The genetic research of height genetics has gone through family single gene linkage analysis to candidate gene association analysis of complex diseases/traits and genome-wide association study. Great achievements have been achieved in every stage of research. So far, hundreds of genetic sites associated with height have been found and identified, which explains part of the mechanism of height genetics. The mechanisms of the stability and accuracy of most of the related gene loci remain unknown. These indicate that height is a complex trait controlled by multiple genes. In this paper, a summary of the genetic research of height is reviewed.]]> 2018/11/22 14:41:34 SONG Hong-chao, LIANG You-fang 310true ［Abstract］　The incidence of glioma is high in primary nervous system tumors. Traditional therapeutic methods have certain limitations for the tumor, and the prognosis of the therapies are poor. Looking for novel molecular target genes is a new breakthrough treatment for glioma. Studies find that small non-coding RNA(miRNA) participates in all the processes associated with cancer, including proliferation, apoptosis, metastasis, angiogenesis and immune response. miRNA plays a role in promoting or inhibiting tumors by inhibiting specific target gene expressions. In this paper,we review the recent progress of miRNA in glioma basic research and the application of miRNA in clinical diagnosis and treatment for glioma.]]> 2018/11/22 14:41:34 LIU Yan, XU Lu 309true ［Abstract］　The purpose of aerosol inhalation therapy is to deliver drugs to the upper and lower respiratory tracts of the patients with respiratory diseases. Compared with other administration modes, aerosol inhalation can achieve higher local drug concentration and reduce systemic adverse reactions. In recent years, aerosol inhalation preparations and technology have been developing rapidly to increase the concentration of drugs in the respiratory tract and improve the curative effect. In this paper, we review the research progress of aerosol inhalation both at home and abroad.]]> 2018/11/22 14:41:34 WU Ming-hui, LIU Qiang, TENG Xiao-ming 308true ［Abstract］　It is known that there is a close relationship between chronic kidney dysfunction and atherosclerosis cardiovascular diseases. Estimated glomerular filtration rate(eGFR) is considered as an independent predictor of coronary stenosis severity, however, whether the decrease of renal function is the risk factor of atherosclerosis remains controversial.In this paper, we aim to review the correlation between the severity of coronary artery stenosis and eGFR as following: First, the clinical evidences of chronic kidney dysfunction and the coronary artery leisions are presented. Second, the prognoses of coronary heart disease(CHD) in the patients with chronic kidney dysfunction are revealed. Third, the potential pathophysiology mechanisms of atherosclerosis and kidney dysfunction are discussed.]]> 2018/11/22 14:41:34 XIONG Ri-xin, ZENG Tao, LIU Ling 307true ［Abstract］　6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4(PFKFB4) is a key enzyme in the pathway of glucose metabolism, which is one of the four subtypes of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase(PFKFB). The main function of PFKFB4 is to synthesize the strongest allosteric activator of phosphoric acid fructose kinase -1(PFK-1), fructose-2, 6-bisphosphate(F-2, 6-BP). PFKFB4 regulates glycolysis flux and promotes the production of ATP, which affects the growth of tumors. Studies have shown that PFKFB4 is essential for the survival of many kinds of tumor cells. In recent years, PFKFB4 has gradually become a new focus on targeted medical therapy. In this paper, we review the roles of PFKFB4 in tumor glucose metabolism and its molecular mechanisms in tumorigenesis, progression and prognosis.]]> 2018/10/26 9:09:11 LI Xi-ming, LI Wei 306true ［Abstract］　Gallbladder cancer is the most common and aggressive malignancy of the biliary tract. Complete surgical resection is the only potentially curative approach in early stage. However, most cases are diagnosed in advanced stages and the response to traditional chemotherapy and radiotherapy is extremely limited, with a modest impact on overall survival. With the recent progress in understanding the molecular alterations of gallbladder cancer, long non-coding RNAs(LncRNAs) has emerged as the key regulators of gene expression and appears to play vital roles in the regulation of multiple cellular biological processes, including apoptosis, tumor invasion and metastasis. LncRNA is hopefully to become a new type of molecular marker and therapeutic target in the diagnosis and treatment of gallbladder cancer.This review discusses the recent remarkable progress in understanding LncRNAs that represent novel prognosis molecular markers and therapeutic targets for gallbladder cancer, which will provide opportunities for research and for developing innovative strategies that may enhance the benefit of conventional chemotherapy.]]> 2018/10/26 9:09:11 BAI Chao, LI Zhi-qiang, NAN Shang-lin, et al. 305true ［Abstract］　Dilated cardiomyopathy(DCM) is mostly appeared as “left ventricular and (or) ventricular enlargement, companied with myocardial contractile dysfunction” clinically, and belongs to a kind of primary myocardial disease, with myocardial cell degeneration, necrosis and myocardial interstitial fibrosis as the main pathological features. At present, the etiology and pathogenesis of DCM are not yet completely clear, and the treatment is only symptomatic lacking effective medical interventions. Gene mutations and genetic factors leading to DCM are research hotspots recently. The common pathogenic genes that are related to DCM are TTN, LMNA, SCN5A, MYBPC3, PLN and TNNT2 which are autosomal dominant manner, but the specific pathogenesises are still unknown. Clarifying the molecular biological mechanism of each gene mutation provides the possibility to establish the early diagnosis of DCM, focus on the accurate targeted therapy and the prognosis of the medical model. This review summarizes the research progress of common pathogenic genes and their pathogenic mechanisms in dilated cardiomyopathy]]> 2018/10/26 9:09:11 HUANG Mei-dan, HE Feng-zhen, ZHANG Zhuo-hua, et al. 304true ［Abstract］　Multiple primary esophageal carcinoma is the presence of two or more discontinuous cancers in the esophagus. Preoperative diagnosis directly affects the choice of treatment modalities and the prognosis and survival time of the patients. Endoscopy is the most intuitive and reliable diagnostic method. Currently, the application of new endoscopes, such as pigmented endoscopy, electronic staining endoscopy and magnifying endoscopy, has effectively improved the detection rates of esophageal carcinoma and multiple primary esophagus. In this paper, the current status and prospect of endoscopic diagnosis of multiple primary esophageal carcinoma are reviewed.]]> 2018/10/26 9:09:11 YI Nan, LIANG Lie-xin 303true ［Abstract］　The nonunion of the lateral humeral condyle in children is one of the complications of lateral humeral condyle fractures,which can cause the elbow dysplasia of bone, losing the matchup of the elbow joints, limb deformities and elbow dysfunctions, severely damaging the children′s physical and mental health. Understanding its causes,anatomy and surgical treatment methods helps to standardize the treatment of lateral humeral condyle fractures and prevent the complications. The research progress in the causes, anatomy and surgical treatment of the nonunion of the lateral humeral condyle in children are reviewed in this paper.]]> 2018/10/26 9:09:11 ZHANG Hui, LIANG Rui-de 302true ［Abstract］　Skeletal class Ⅲ malocclusion is common in clinic. Its characteristics are that the mandible is relatively anterior and the midface is sunken deformity. It not only affects chewing, language, breathing and other physiological functions, but also has an impact on facial beauty which is often accompanied with serious psychosocial problems, and the rate of clinical consultation is high. The upper airway is also known as the human “life cavity”, and obstruction of the upper airway will affect normal breathing and sleep. The upper airways have different changes during the orthodontic treatment due to many different factors in the patients with skeletal class Ⅲ malocclusion. Therefore, it is important to understand the upper airway characteristics of skeletal class Ⅲ malocclusion and to explore the effects of different treatments on the upper airway. We briefly review the advances in upper airway space of the patients with skeletal class Ⅲ malocclusion in this paper.]]> 2019/9/30 8:42:00 HU Hong-yun, NIE Gai-yun, LIANG Rong, et al. 301true ［Abstract］　Intrahepatic bile duct stones(IBDS) is one of the common diseases in hepatobiliary surgery. The causes of IBDS are complex and its treatment is difficult. IBDS has many complications and high incidence of postoperative recurrence, seriously affecting the quality of the patients′ life. Currently, the recurrence mechanism of IBDS in clinical practice is not completely clear, and may be related to bacterial and parasitic infections, recurrent cholangitis and cholestasis, genetic environment and dietary metabolism, and initial treatment mode and timing selection. With the development of modern medical technology, various treatment methods have emerged one after another. Precise hepatectomy, percutaneous hepatic choledochoscopy（PTCS）, various endoscopic and lithotriptic minimally invasive techniques have developed rapidly. In this paper, the etiological mechanism of recurrence of hepatolithiasis and its treatment progress are summarized, so as to provide some basis for clinical treatment and prevention of recurrence of IBDS after operation and to alleviate the patients′ pain and improve their quality of life.]]> 2019/9/30 8:42:00 FAN Hai-jun, TIAN Da-guang, WEI Xiao-ping 300true ［Abstract］　Evidence-based medicine has proved that laparoscopic complete staging can be an ideal operation for endometrial cancer. The oncological outcomes of laparoscopic surgery for endometrial cancer are as good as those of an open approach but with many benefits. With the success of laparoendoscopic single-site surgery(LESS) in the number of stages of endometrial cancer, more and more evidence shows that there are no significant differences in intraoperative and postoperative complications and long-term efficacy between LESS and traditional laparoscopic surgery. LESS has been gradually used in staging operation of endometrial carcinoma because of its advantages of aesthetics, less postoperative complications and faster postoperative recovery. Due to the difficulty of the operation and long-time learning, and lacking large samples and long-term studies, LESS has not been widely used in the staging of endometrial carcinoma. But with advances in technology and physician practice skills, LESS will play an increasingly important role in the staging of endometrial cancer, which will benefit more and more female patients.]]> 2019/9/30 8:42:00 XU Yu-quan, ZHAO Ren-feng 299true ［Abstract］　With the rapid development of industrial modernization and transportation industry, all kinds of high-energy injury lead to thoracolumbar fractures, causing great harm to people′s health. Performing standardized treatment of thoracolumbar fractures has become a challenge for orthopaedic surgeons. After several decades of research, there are some certain consensuses on the classification of thoracolumbar fractures, the choice of surgical approaches and surgical methods in spite of some problems to be worked out. The classification, treatment principles, surgical approaches and surgical methods of thoracolumbar fracture are reviewed in this paper to provide reference for diagnosis and treatment of the disease.]]> 2019/9/30 8:42:00 LU Xian-wei, WEI Wei 298true ［Abstract］　Rectal cancer is a common and frequently-occurring disease, and minimally invasive surgery is the development trend of treating rectal cancer. In this paper, we review the surgical treatment of rectal cancer, the origin and application of transanal total mesorectal excision（TaTME）, TaTME indications and its efficacy, and anastomosis reconstruction.]]> 2019/9/2 14:45:32 XU Sheng, HUANG Shun-rong 297true ［Abstract］　Because of the increasing population of the elderly, cerebrovascular diseases have become one of the main causes of death in them. Therefore, it is the common aspiration of medical workers in the world to further study the mechanism of the occurrence and development of ischemic stroke and actively carry out effective early prevention. In this paper, we review the research progress of purinergic 2X7(P2X7) receptor in the pathogenesis of ischemic stroke to provide theoretical basis for the treatment of ischemic stroke.]]> 2019/9/2 14:45:32 WANG Yi-xin, ZHANG Feng-fan, QIAO Xiang, et al. 296true ［Abstract］　The patients with chronic heart failure (CHF) have a high incidence of cognitive impairment, which can reduce the quality of life and increase the disability rate of the patients. In this paper, we review the research progress on cognitive impairment and its influencing factors in CHF patients.]]> 2019/9/2 14:45:32 CHEN Xiao, JIANG Wei, ZHANG Jia-wei, et al. 295true ［Abstract］　Gastroesophageal reflux disease(GERD) results from incompetency of the lower esophageal sphincter that allows the contents of the stomach and duodenum to reflux into the esophagus, the airways, and the mouth, causing discomfort and/or complications. The main symptoms include heartburn and reflux. At present, the main treatment methods of GERD include medications, endoscopic and surgical treatments. However, most patients have to take proton pump inhibitors for long-term therapy and put up with multiple postoperative complications or poor curative effects. LINX anti-reflux system is a new therapeutic technique emerging in recent years, and has its unique advantages in treatment of GERD. In this paper, we review the advances in the study on LINX anti-reflux system for treatment of GERD.]]> 2019/9/2 14:45:32 YUE Bin, TANG Xiao-dan. 294true ［Abstract］　Dry eye is a common chronic eye disease in clinical practice, but it is more and more concerned by people because its incidence has been increasing in recent years. However, there is no globally recognized classification of dry eye at present, although its definition and classification have been updating constantly with in-depth researches. In 1995, the National Eye Institute/Industry Workshop(the USA) proposed the definition and classification of dry eye, which will help to build a foundation for future researches. Later on, Tear Film and Ocular Surface Association(TFOS) issued Dry Eye Workshop Ⅰ(DEWS Ⅰ) and Dry Eye Workshop Ⅱ(DEWS Ⅱ) in 2007 and 2017 respectively, making significant progress in all aspects of dry eye research. In 2013, the first consensus of dry eye was established by the Corneal Disease Group of the Chinese Ophthalmological Society to guide significantly for the diagnosis and treatment of dry eye in China. Based on the above four expert consensus, the authors summarize the research status of the definition and classification of dry eye in this paper.]]> 2019/8/5 16:14:39 YU Se-jie, CHEN Zi-lin 293true ［Abstract］　Recently, the incidence of differentiated thyroid cancer is increasing gradually. Although the current treatment of differentiated thyroid cancer is mainly depending on surgery, the thyroid cancer with poor prognosis still relies on other types of therapy. Elucidating the mechanism by which proliferation and differentiation of differentiated thyroid cancer cells are regulated would help identify preventive and therapeutic targets for the disease. The regulatory mechanism of proliferation and differentiation of thyroid cancer is reviewed in this paper.]]> 2019/8/5 16:14:39 LIU Zhen-ming, LIU Ping-tao, XIE Zhong-jian 292true ［Abstract］　Calcitonin gene-related peptide(CGRP) is a kind of sensory neuropeptide that can strongly vasodilate blood vessels and has the effects of reducing myocardial ischemia/reperfusion injury(MI / RI), but the exact mechanism is still unknown. Myocardial ATP-sensitive potassium channels(K_ATP) have the effect of associating cell metabolism with the excitability of the cell membrane and involve the protection of arrhythmias and heart failure. Moreover, K_ATP channel may be a key node in the pathway of CGRP to reduce MI/RI. This paper aims at stating the role of K_ATP in myocardial protection of CGRP, and the mechanism of CGRP in reducing MI/RI is further described.]]> 2019/8/5 16:14:39 WANG Chen, YUAN Da-jiang 291true ［Abstract］　Cesarean section is one of the most common operations in obstetrics department, yet the pain after cesarean section should not be ignored. Good postoperative analgesia can significantly alleviate the pain and postoperative complications, and promote the recovery of the puerperants. In this paper, we review the research progress on postoperative analgesia after cesarean section and focus on the analgesia modes of cesarean section and the new medications.]]> 2019/8/5 16:14:39 WEI Shan-shan, WEI Ning, LIANG Xiang-ping 290true ［Abstract］　Fatty pancreas(FP) is proposed and studied in recent years, whose main manifestations are that fat accumulates inside and outside the cells of pancreatic parenchyma. Currently, it is clinically diagnosed by ultrasound, computed tomography(CT), magnetic resonance(MR) and other methods and has been found to be associated with diabetes, pancreatic cancer and other diseases in clinical studies. In this paper, we review the researches of its clinical diagnosis and clinical implications.]]> 2019/7/1 16:32:50 LIN Hai-ping, YU Shi-an 289true ［Abstract］　Hepatic fibrosis(HF) is an early stage of liver cirrhosis and can be caused by various chronic liver diseases. The continuous activation of hepatic stellate cells is the key link in the development of HF. For the most part, the pathway and mechanism involving the activation of hepatic stellate cells have been explained. However, the effects of calcium signal regulation on the activation of hepatic stellate cells and the collagen expression of hepatic stellate cells are still unclear. In this paper, the relationship between calcium signal and HF is reviewed to provide new ideas for the study of HF.]]> 2019/7/1 16:32:50 ZHANG Ying-geng, ZHANG Guo 288true ［Abstract］　Tuberculous meningitis(TBM) is a common extrapulmonary tuberculosis. It is serious, fast changing and harmful. Its morbidity and mortality are high. The clinical manifestations of TBM are not specific, and the sensitivity of laboratory tests is poor. Therefore, its diagnosis is still difficult. At present, the diagnosis of TBM is mainly based on clinical manifestations, laboratory tests and imaging examinations. Early diagnosis and timely and reasonable treatment of TBM are important factors to improve prognosis. The advances in diagnosis and treatment of TBM are reviewed in this paper.]]> 2019/7/1 16:32:50 WANG Xiao-feng, CHEN Nan-hui 287true ［Abstract］　Sarcopenia is a progressive disease, associated with physiological aging process and defined by the reduction of the muscle mass, strength and/or function. Patients with chronic kidney disease secondarily appear decreased muscle strength, selective muscle structure changes and significant muscle atrophy due to decreased appetite, low protein intake, chronic inflammation, metabolic acidosis and protein-energy wasting are diagnosed with uraemic sarcoprnia. Sarcopenia severely reduces the quality of life of dialysis patients, and increases the patients′ disability rate and death rate. Early detection, diagnosis, prevention and treatment of sarcopenia are essential for improving the quality of life of uraemic patients. The research progress of uraemic sarcopenia is reviewed in this paper.]]> 2019/7/1 16:32:50 LI Qiong-xiang, GUO Ai-ling, WENG Min 286true ［Abstract］　Acute kidney injury(AKI) is one of the most common complications of decompensated cirrhosis, and it primarily presents as a sharp decrease in glomerular filtration rate, rapid increase in serum creatinine(SCr) and urea nitrogen, water and sodium retention. At present, the sensitivity of SCr and urea nitrogen in clinical evaluation of renal function is low and susceptible to non-renal factors. Therefore, the search for specific and sensitive early diagnostic markers has been a research hot spot in recent years. This article summarizes the early detection indicators of liver cirrhosis complicated with AKI in recent five years, and provides the basis for clinical diagnosis and treatment.]]> 2019/5/31 17:17:33 LI Fang-fang, WANG Sheng-lan 285true ［Abstract］　Total knee arthroplasty(TKA) is mainly used in knee osteoarthritis, rheumatoid arthritis and other end-stage knee arthritis,which can restore the lower limb alignment and reconstruct the knee joint function. However, some problems that may ooccur after TKA include increasing drainage fluid and the hidden recessive blood loss, pain, swelling and ankylosis. Cryotherapy refers to using ice on the skin surface in vitro, which makes temperature of the muscle tissues and articular reduce because of conduction of heat, and then stimulates the sympathetic nerve and produces vasoconstriction. Cryotherapy can relieve pain, reduce bleeding and swelling, and promote joint function rehabilitation in TKA patients. So far, it is not clear what the proper treatment time, temperature and frequency of cryotherapy are. Some complications like skin frostbite, paralysis and wound infection may occur if the cryotherapy is performed for a long time or at a low temperature. Low temperatures may also reduce the patients′ comfort and cause poor quality of sleep. The research progress of cryotherapy in patients with TKA is reviewed in this paper.]]> 2019/5/31 17:17:33 SHI Wei-fa, WANG Cheng-long, HUANG Xiao, et al. 284true ［Abstract］　Acromioclavicular joint is a amphiarthrosis consisting of distal clavicle, medial side of shoulder, coracoid and coracoclavicular ligament, coracoclavicular ligament and acromioclavicular ligament. Acromioclavicular joint injury is a relatively common clinical shoulder injury. Currently, there are many ways to treat acromioclavicular joint dislocation in clinical practice, but there are still postoperative shoulder pain, impingement syndrome and internal fixation failure complications relating to the limitations of recognizing acromioclavicular joint anatomy and biomechanics. In this paper, we review the advances in applied anatomy and biomechanics of acromioclavicular joints.]]> 2019/5/31 17:17:33 LIANG Zhen, FENG Zong-quan, OU-YANG Han-bin, et al. 283true ［Abstract］　Cesarean scar pregnancy(CSP) is a special ectopic pregnancy. In recent years, with the implementation of two-child policy and an increasing number of cesarean section, the incidence of CSP is increasing. Because of its clinical symptoms and serum beta HCG having no specificity and inadequate knowledge of the disease, CSP is easily misdiagnosed, which causes serious consequences. Ultrasound is a preferred examination for CSP. In this paper, we review the progress of CSP diagnosed by ultrasound.]]> 2019/5/31 17:17:33 ZHANG Xia, CHEN Zhao-bei, SU Hai-qing 282true ［Abstract］　Pancreatic ascites is an intractable complication that is particularly challenging to manage in clinics. The research progress in pathogenesis, clinical manifestations, clinical examinations, diagnosis and treatments of pancreatic ascites is reviewed in this paper.]]> 2019/4/30 17:22:17 KONG Fan-biao, WU Dong-bo, WANG Xiao-tong 281true ［Abstract］　Tubeless single-port video-assisted thoracic surgery(tubeless VATS) is an advanced technology in accordance with the concept of enhanced recovery after surgery. The research progress of tubeless single-port video-assisted thoracic surgery under the guidance of enhanced recovery after surgery is reviewed in this paper and we focus on four aspects of tubeless VATS: (1) anesthesia methods of tubeless VATS; (2) clinical practice of tubeless VATS in pulmonary bullae resection, therapy of palmar hyperhidrosis, pulmonary biopsy, sub-lobectomy, lobectomy and mediastinal tumor resection; (3)advantages of tubeless VATS; (4)disadvantages of tubeless VATS; (5)vista of tubeless VATS.]]> 2019/4/30 17:22:17 YUE Han-xun, ZHANG Yu, LIN Rui-jiang, et al. 280true ［Abstract］　Maisonneuve fractures of the fibula(MFF) are special types of ankle injury, which is characterized by the injury of proximal 1/3 of the fibula fracture, lower tibiofibular joint and medial malleolus. It is commonly believed that MFF is a spinning-type fracture, however some scholars put forward some different points of view in recent years. The incidence of MFF is low, and this type of fracture is extremely unstable. Many scholars have studied the traumatic mechanism and treatment of MFF, and there is obvious dispute about the degree of dissection of the lower tibia, the extent of interosseous membrane damage and the choice of treatment methods. In recent years, scholars from all over the world put forward some new concepts of MFF development mechanism and treatment methods to raise the public awareness of the disease. In this paper, we review the research progress in diagnosis and treatment of MFF.]]> 2019/4/30 17:22:17 LI Shuo, ZHANG Yu, SUN Zheng-tao, et al. 279true ［Abstract］　The morbidity of male infertility increases progressively year by year, but clinically, the evaluation of male fertility still mainly relies on routine semen analysis. It is not enough to meet the requirement in current clinic practice. Some new indexes have been discovered and play important roles in this field. As one of the indicators for male fertility, acrosin activity has become a research hotspot for many years. In this paper, we review the function of acrosin activity, influencing factors,drug treatments and the research advances in assisted reproduction to provide a new idea for the diagnosis and treatment of male infertility.]]> 2019/4/30 17:22:17 LI Yuan-fa, LIANG Ji-hong 278true ［Abstract］　Fat is one of the three main energy sources. Adipose tissue is the important energy storage. The discovery of adipokine reveals another important identity of adipose tissue—endocrine organ. Adipokines are cytokines secreted by adipose tissue. Chemerin is a newly discovered adipokine which is closely related to high blood pressure, coronary atherosclerosis and heart failure. In this paper, the mechanisms of chemerin in cardiovascular diseases are reviewed.]]> 2019/4/1 16:03:54 HU Zhen, ZOU De-ling 277true ［Abstract］　Enhanced recovery after surgery（ERAS） refers to various perioperative management measures based on evidence-based medicine to promote the early postoperative rehabilitation of patients. After more than 20 years of development, ERAS has been widely used in gastrointestinal surgery, hepatobiliary surgery, urology surgery and other fields, but it is not given received enough attention in the field of craniocerebral surgery. The application of ERAS in craniocerebral surgery is reviewed in this paper to promote its application in the surgery.]]> 2019/4/1 0:00:00 LI Jia-wei, WANG Xiang-yu 276true ［Abstract］　As a new rehabilitation treatment technique, sling exercise therapy(SET) has been applying more and more widely in the field of rehabilitation. Because of the uniqueness and the importance of pediatric rehabilitation in the rehabilitation medicine system, we review the current status and prospects of studies on SET in pediatric rehabilitation application in this paper.]]> 2019/4/1 16:03:54 LIU Yuan-cheng, LI Lie-wang, LIU Zhen-ling 275true ［Abstract］　With the improvement of biomaterial technology and people′s living standards, traditional multifocal intraocular lens can initially solve the problems of cataract and distant and near vision problems in presbyopia patients, but the lack of distance vision and glare problem that is easy to be produced, night vision difference and poor visual effects still plagued the patients. In recent years, the new multifocal intraocular lens which have the advantage of improving the medium-distance vision, not only provide continuous high-quality vision, but also reduce the incidence of optical interference, and have become a popular choice in clinical practice. In this paper, we review the design principles, clinical application effects and existing problems of several new intraocular lens that are widely used at home and abroad.]]> 2019/4/1 16:03:54 JIAN Fei-long, SUN Kang, BI Wu-mu, et al. 274true ［Abstract］　Nasopharyngeal carcinoma(NPC) is one of the most common malignant tumors occurring in the head and neck in southern parts of China. About 10.00% to 36.00% of the patients with NPC suffer from local recurrence, and the effects of retreatment are unsatisfactory. With the advent of new treatments,more patients with recurrent NPC have better curative effect. In this paper, we review the treatment methods and advanced research on treatment of recurrent NPC.]]> 2019/4/1 16:03:54 LIANG Lei-feng, LIN Zhan 273true ［Abstract］　Interleukin 33(IL-33) is the 11th member of the IL-1 cytokine family and a double-function factor. After binding to TIR(Toll/IL-1R) receptor ST2L, IL-33 activates NF-κB and MAP kinases in immune cells, which potently drives the production of Th2-associated cytokines and chemokines and plays an important role in the development of allergic rhinits(AR). In this paper, we review the biological characteristics of IL-33 and its role in AR.]]> 2019/3/4 16:47:08 QIN Tai-jie, QU Shen-hong 272true ［Abstract］　The recent development of platelet-rich concentrate(PRC) is an evolution of the fibrin glue technologies used for many years. The initial concept of these autologous preparations is to concentrate platelets and their growth factors in a plasma solution, and to activate it into a fibrin glue on a surgical site, in order to improve local wound healing. Currently, PRC has been widely used in various medical fields owing to its advantages such as being autogenous, easy technique, time and cost effectiveness, and avoiding problems such as allergies, rejection reactions and ethical issues. Hence, the aim of this article is to review the biological properties of PRC and the advancement of different preparations in skin wound healing.]]> 2019/3/4 16:47:08 QIAO Xin-ting, LU Fa-qiang 271true ［Abstract］　Aphasia is one of the most common complications after stroke. Currently, the clinical effects of rehabilitation on aphasia after stroke are limited. As a noninvasive technique, transcranial magnetic stimulation(TMS) can facilitate the language network remodeling and implement the language rehabilitation. The research progress of TMS, language network, post-stroke language spontaneous recovery mechanism and the impact of TMS on post-stroke aphasia is reviewed in this paper.]]> 2019/3/4 16:47:08 CAO Wan, CHEN Zhuo-ming 270true ［Abstract］　Laparoscopic splenectomy has been widely used at home and abroad. It has the advantages of small trauma, less bleeding, faster recovery and shorter hospital stay. This paper introduces the characteristics of operative methods, including laparoscopic splenectomy, hand assisted laparoscopic splenectomy, single hole laparoscopic splenectomy, laparoscopic splenectomy, gasless laparoscopic partial splenectomy, natural orifice transluminal laparoscopic splenectomy and robot assisted laparoscopic splenectomy, and their clinical effects and application prospects.]]> 2019/3/4 16:47:08 WANG Zu-lai, HUANG Shun-rong 269true ［Abstract］　Community acquired pneumonia(CAP) is one of the common diseases in the respiratory system. Most of the CAP patients can be cured, however some of them do not respond to the first treatment even some become worsened. It is very important to find out the causes of non-responding pneumonia. We review the etiology of non-responding pneumonia in this paper.]]> 2019/1/31 16:31:42 AN Dong-shan, SHI Peng, WU Chun-feng, et al. 268true ［Abstract］　G-protein-coupled bile acid receptor, Gpbar1 (TGR5) is a member of the G-protein-coupled receptor(GPCR) superfamily. TGR5 expresses in various tissues, including the small intestine, stomach, liver, lung, placenta and spleen, and participates in the occurrence of many metabolic diseases in the body. TGR5, as a metabolic regulatory receptor, involves in glucose and lipid metabolism, reducing insulin resistance and increasing the body′s energy metabolism, regulating bile acid balance and keeping the metabolism system in a steady state. This review mainly focuses on the research progress of TGR5 in liver metabolism and its clinical significance in the related liver diseases.]]> 2019/1/31 16:31:42 WU Xiao-xian, WANG Xiao-ning 267true ［Abstract］　Chronic functional constipation is a common intestinal disease. Researches show that chronic functional constipation is related to intestinal microflora disorder, and microecological preparations that improve the intestinal flora disorder have a good clinical effect on chronic functional constipation. In recent years, some treatments of intestinal microflora disorder have made a certain progress in the field of chronic functional constipation, especially for the treatment of fecal bacteria transplantation(FMT) that has achieved good results. In this paper, we review the research progress of FMT in treatment of chronic functional constipation.]]> 2019/1/31 16:31:42 LI Shi-jun, WU Jian-guo, PENG Zhi-yang, et al. 266true ［Abstract］　The common treatments for painful heel syndrome(PHS) include oral non-steroidal anti-inflammatory drugs, local hormone occlusion injection, plantar fascia, acupuncture, massage and surgery. These therapies have certain curative effects on PHS, but still have the following defects: high recurrence rate, slow effect, long course of treatment and problems of insisting. As the modernization of Traditional Chinese Medicine in acupotomology improvement, small needle knife therapy strips inflammation parts from normal soft tissues, promotes local blood circulation and makes nutrients and anti-inflammatory factors locate in inflammatory sites. As a physical therapy, shock wave penetrates soft tissues to reach the inflammatory sites and eliminates the local inflammations noninvasively. Combining the two methods for the treatment of PHS has achieved good clinical effects.The clinical research progress of small needle knife therapy combined with extracorporeal shock wave therapy for heel pain is reviewed in this paper.]]> 2019/1/31 16:31:42 ZHAO Sheng-chao, YE Yi-jie, WU Bo, et al. 265true ［Abstract］　It has been confirmed that atrial fibrillation is a chronic inflammatory pathological process, and its occurrence and development are always accompanied by inflammatory response. Galectin-3 is an inflammatory factor, involving in the process of cell adhesion,proliferation and apoptosis. Recent studies have found that galectin-3 plays an important role in the occurrence and development of atrial fibrillation, and is an important biochemical marker for atrial fibrillation. Galecin-3 is expected to become a new target for atrial fibrillation treatment. We review the research progress of the galectin-3 and atrial fibrillation in this paper.]]> 2019/1/31 16:31:42 LI Qing-kuan, QIN Shao-ming 264true ［Abstract］　Lymph node metastasis is one of the important risk factors affecting the prognosis of gastric cancer patients. Currently, pathological biopsy is the only examination method that can confirm the positive lymph node metastasis. However, the perigastric lymph nodes are widely distributed and their anatomical positions are variable. Therefore, it is difficult to conduct biopsy of lymph nodes before operation. Among the existing examination methods, whether endoscopic ultrasound(EUS), multidetector-row computed tomography(MDCT) or magnetic resonance imaging(MRI), the diagnosis of lymph node metastasis is currently based on morphology. This paper reviews the research progress of imaging diagnosis and staging of lymph node metastasis of gastric cancer.]]> 2019/12/30 10:12:41 BAI Hui-hui, DENG Jing-yu 263true ［Abstract］　Deafness is one of the major human disabilities, and seriously affects the patients′ physical and mental health and quality of life. Genetic factors are the main causes of deafness and gene diagnosis of deafness has gradually developed into a necessary screening tool. The frequencies and hot spots of mutations of common genes(GJB2, mitochondrial 12S rRNA, SLC26A4 and GJB3) are significantly different among different countries, regions, human races and ethnic groups. In this paper, the advances in research on the correlation between common deafness gene mutations and regional and ethnic differences are reviewed.]]> 2019/12/30 10:12:41 ZHOU Kai, LIU Shui-xia, FENG Meng-long, et al. 262true ［Abstract］　Sling exercise therapy is a method of controlling the training of the body′s core muscle groups in an unstable state. In recent years, sling exercise therapy has become more and more popular in modern clinical rehabilitation and competitive sports training. In this paper, we review the mechanism of sling exercise therapy in improving neck and low back pain and the research progress of its clinical application.]]> 2019/12/30 10:12:41 DENG Jiao, HOU Wei-lin, CHI Hui, et al. 261true ［Abstract］　B cell-specific Moloney murine leukemia virus integration site 1(Bmi-1) is a member of the polycomb repressor complex 1(PRC1) that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells. This paper summarizes the progress of research on polycomb group protein, Bmi-1 in gynecological oncology.]]> 2019/12/30 10:12:41 QIN Rui, NONG Wen-zheng, MO Qiu-rong 260true ［Abstract］　Circulating tumor cell is an important tumor marker, and the detection of circulating tumor cell is a research hotspot in liquid biopsies in recent years. Esophageal cancer and gastric cancer are both malignant tumors with high morbidity and mortality, and dynamic monitoring of the number of circulating tumor cells is of great clinical significance in judging the early metastasis, chemotherapy efficacy and long-term prognosis of the two tumors. In this paper, we review the research progress in the expressions and clinical significances of circulating tumor cells in esophageal cancer and gastric cancer.]]> 2019/11/28 12:01:08 SHI Gao-kai, YANG Wan-li, HONG Liu, et al. 259true ［Abstract］　In recent years, the incidence of stroke increases year by year, with high mortality and morbidity, and convulsion is one of the most common complications of stroke. Clinical management of muscle spasms is directly related to the prognosis of the stroke patients, and the treatment of muscle spasms has been focused in the field of rehabilitation. Currently, there are some treatments for muscle spasms after stroke and their clinical effects are different. In this paper, the advances in treatment of muscle spasms after stroke are reviewed.]]> 2019/11/28 12:01:08 LIANG Hui, LU Ying, LIU Xi-xia, et al. 258true ［Abstract］　Kawasaki disease(KD) is predilection in infants and young children under 5 years of age. KD mainly affects small and medium blood vessels of the whole body, and its complications are aneurysm formation and coronary artery expansion. KD has become the main cause of pediatric acquered heart disease. At present, the pathogenesis of KD is still unclear. The diagnosis of KD is mainly based on its clinical features, laboratory and imaging examinations, and the clinical treatment of KD needs to be further improved. The research progress in pathogenesis, diagnosis and treatment of KD is reviewed in this paper.]]> 2019/11/28 12:01:08 CHEN Yong-qin 257true ［Abstract］　Obstructive sleep apnea（OSA） is a sleep disorder characterized by snoring and recurrent partial or complete collapse of the pharyngeal airway. OSA may result in excessive daytime sleepiness, neurocognitive and cardiovascular impairments. Wearing oral appliances is an effective treatment for OSA. The changes of airway structure on OSA, mechanism on oral appliances, subjective and objective evaluations of therapeutic effects of oral appliances, effects of oral appliances on hypertension, neuropsychology, sleep structure of OSA after using oral appliances and side effects are reviewed in this paper.]]> 2019/10/30 0:00:00 WANG Ling, RAO Ming-cong, HUANG Min-fang 256true ［Abstract］　Overactive bladder syndrome(OAB) is a group of syndromes characterized by frequent urination and urinary urgency, seriously effecting the quality of life in children with OAB. Solifenacin succinate is a new generation of muscarinic acetylcholine receptor(M receptor) antagonist with high selectivity for detrusor, and obviously relieves the symptoms of OAB in children. Small doses of solifenacin treatments for children with OAB are safe and effective. In this paper, we review the research progress of solifenacin succinate in treatment of OAB in children.]]> 2019/10/30 0:00:00 GONG Jin-wei, LI Chao-ming 255true ［Abstract］　Vitamin K₁(VitK₁) is indispensable as a cofactor for the synthesis of blood coagulation factors in infants and young children. Because of large changes of VitK₁ in serum concentration, the shortage and deficiency of VitK₁ can cause bleeding after blood vessel injury in infants and young children. Supplementing VitK₁ timely and adequately can stop the bleeding, while an excessive dosage can affect the blood coagulation function of the body. The blood coagulation function of infants and young children does not fully develop, which corresponds to the physiology of their blood circulation, and which will be perfected during growth and development. VitK₁ is necessary for the synthesis of clotting substances, which is closely related to the improvement of blood coagulation function in infants and young children. In this paper, the relationship between serum concentration of VitK₁ and the blood coagulation function in infants and young children is reviewed.]]> 2019/10/30 0:00:00 CHEN Hong-bing, LU Yan 254true ［Abstract］　Chronic intermittent hypoxia(CIH) is one of the typical physiological and pathological characteristics of obstructive sleep apnea syndrome(OSAS), and is a key initial factor leading to multi-organ system injury of OSAS. Toll-like receptor 4(TLR4), as a highly conserved immune receptor, participates in a variety of inflammatory responses and inflammatory cascades. In recent years, the role of TLR4 signaling pathway in CIH inducing inflammatory response has attracted more and more attention and research, providing new targets for the diagnosis and treatment of OSAS. In this paper, we review the recent advances in CIH, TLR4, TLR4 gene silencing technology and antagonists.]]> 2020/9/30 16:48:19 LI Xin-lan, WANG Ye-ying, LI Yong-xia 253true ［Abstract］　Antithrombotic therapy is vital to the patients with ST-segment elevation myocardial infarction. The optimal strategy of anticoagulation in the patients with ST-segment elevation myocardial infarction remains unclear. In this paper, we review the research progress in the application of bivalirudin in the patients with ST-segment elevation myocardial infarction.]]> 2020/9/30 16:48:19 CHEN Shuai, NING Bin 252true ［Abstract］　With the development of in vitro fertilization-embryo transfer(IVF-ET), it has become a conventional assisted reproductive technology, which helps many infertile couples to solve their reproductive problems, but there are still many problems to be solved, such as low fertilization rate, low clinical pregnancy rate and how to ensure the quality of transferred embryo transfer development. Sperm acrosome integrity is closely related to male infertility. In recent years, more and more scholars at home and abroad have paid attention to the relationship between sperm acrosome integrity and IVF-ET outcomes. In this paper, we review the research progress of the effects of sperm acrosome related knowledge and sperm acrosome integrity on IVF-ET fertilization rate, cleavage rate, good embryo rate, implantation rate, clinical pregnancy rate, live birth rate and abortion rate outcomes.]]> 2020/9/30 16:48:19 CHEN Qi-gui, LI Da-wen 251true ［Abstract］　The resistance of tumor cells to anti-tumor drugs is an important cause of treatment failure, and its mechanisms and reversal strategies have not been completely solved up to now. In recent years, the idea that tumor associated microbiota leads to drug resistance has been gradually confirmed. In this paper, the research progress on the correlation between microbiota and the efficacy of chemotherapy drugs, immunotherapy drugs and targeted drugs, and the reversal of drug resistance are reviewed.]]> 2020/9/30 16:48:19 LEI Yu, WU Qiong, LIANG Xue-hong, et al. 250true ［Abstract］　Linitis plastica is a special type of gastric cancer with diffuse growth, high malignancy, rapid development and usually poor prognosis. It belongs to diffuse infiltration(Borrmann Ⅳ) gastric cancer, and is more common in women. The improvement of diagnosis and treatment technology provides a new hope for the diagnosis and treatment of some linitis plastica patients. The specific pathogenesis and disease progression of linitis plastica have not been completely clear, so we review the diagnosis and treatment status and progress of linitis plastica in recent years in this paper.]]> 2020/9/2 15:08:59 WU Zi-zhen, DENG Jing-yu, LIANG Han 249true ［Abstract］　Periodontitis is a chronic inflammatory disease induced by periodontal pathogens and manifested by the progressive loss of periodontal supporting tissues, especially bone tissue. Recently, researches have revealed that autophagy and its associated proteins take effects on inflammatory process by mutual regulation with cytokines and inflammasomes. Meanwhile, autophagy and its related proteins act on bone tissue cells, especially participate in the genesis, differentiation and function of osteoclasts. This review focuses on how autophagy interacts with periodontitis and bone cells and its related research progress, aiming to elaborate the role of autophagy in periodontitis-induced bone loss to provide a new target for clinical treatment of periodontitis.]]> 2020/9/2 15:08:59 LIAN Lu-ya, ZHU Hai-hua 248true ［Abstract］　Non-alcoholic fatty liver disease(NAFLD) has a high incidence in breast cancer patients during chemotherapy and endocrine therapy. NAFLD is a common case of hepatic dysfunction and abnormal liver enzymes, and therefore affects the therapy and prognosis of breast cancer patients. However, the prevention and treatment of NAFLD has not attracted enough attention. In this paper, we systematically review the management, prevention and treatment of NAFLD in breast cancer patients during adjuvant therapy to raise awareness of NAFLD and further improve the quality of life and prognosis of breast cancer patients.]]> 2020/9/2 15:08:59 TIAN Shen, WU Juan, KONG Ling-quan, et al. 247true ［Abstract］　Severe traumatic brain injury(sTBI) is a disease with extremely high mortality and disability rate worldwide. Transcranial Doppler(TCD) ultrasound can efficiently and safely monitor the pathophysiological changes of sTBI patients at the bedside, and its detection results are highly reproducible.TCD can obtain the two-dimensional morphology of brain tissues in a non-invasive and real-time manner. The cerebral hemodynamic information is obtained by calculating the blood flow state of intracranial vessels, and the intracranial pressure is evaluated by analyzing the velocity and direction of cerebral blood flow, the function of vascular self-regulation and the change of vascular resistance. This paper reviews the clinical application status and prospect of bedside TCD in the treatment of craniocerebral trauma.]]> 2020/9/2 15:08:59 SHEN Yin, LYU Li-wen 246true ［Abstract］　Mandible has direct influence on facial aesthetics and maxillofacial function. In early researches, the morphological structure and position of mandible were mainly analyzed by lateral cephalometric radiographs. With the increasing application of cone-beam computed tomography(CBCT), three-dimensional cephalometry and three-dimensional superimposition can be used to analyze the morphological structure and position of mandible, so as to better guide the scientific research and clinical work in the fields of orthodontics and orthognathic surgery. In this paper, we review the research progress in three-dimensional measurement of mandible shape and position.]]> 2020/8/3 9:08:34 PANG Hui-qi, CHE Xiao-xia 245true ［Abstract］　Inflammasomes are important components of the innate immune system, among which NOD-like receptor protein 3(NLRP3) is a research hotspot. NLRP3 is involved in the occurrence and development of various chronic inflammatory diseases by activating the corresponding signaling pathways. Recent researches demonstrate that inflammasome NLRP3 plays a vital role in the pathogenesis of various diseases, such as atherosclerosis(AS), non-alcoholic fatty liver disease(NAFLD), Alzheimer ′s disease(AD), chronic obstructive pulmonary disease(COPD) and chronic renal disease. In this paper, we review the research progress of inflammasomes and chronic inflammatory related diseases.]]> 2020/8/3 9:08:34 LIN Kai-ling, XUE Yan, YU Hui-zhen 244true ［Abstract］　Skeletal class Ⅱ malocclusion is one of the common malocclusions in clinical practice. The patients with skeletal class Ⅱ malocclusion often have open lips and exposed teeth, which causes adverse effects on oral cavity function, facial beauty, mental health, and often accompanied by respiratory system structure and function abnormalities. The morphology of upper airway plays a very important role in respiratory function and speech function. There is a close relationship between the morphology of upper airway and craniomaxillofacial morphology and structure. Orthodontic treatments can improve cranial and maxillofacial bone structure of skeletal class Ⅱ malocclusion patients. The upper airway is a part of the cranial and maxillofacial bone structure and can also undergo corresponding changes. In this paper, the characteristics of the upper airway of skeletal class Ⅱ malocclusion and the effects of different orthodontic treatments on the morphology of the upper airway are reviewed.]]> 2020/8/3 9:08:34 NIE Gai-yun, HU Hong-yun, LIANG Rong, et al. 243true ［Abstract］　Over the past two decades, with the progress of science and technology, great findings of microsaccades in neural basis and physiological effects and its relationship with cognition have been achieved. The research of microsaccades has been one of the most rapid growing fields in visual neuroscience. It is not only a tool to understand the nature of vision, but also with great significance of both basic and clinical research in amblyopia. In this paper, we review the research status of neurophysiolog of microsaccades.]]> 2020/8/3 9:08:34 ZHAO Wu-xiao, GAN Lu, LAN Fang-fang 242true ［Abstract］　Breast cancer is a malignant tumor with the highest morbidity and mortality among middle-aged and elderly women, and the patients who get this cancer become younger and younger. The occurrence and development of breast cancer are regulated by many factors, and its etiology and pathogenesis are not completely clear. This paper aims to investigate the structure and function of the Chemokine(C-X-C motif) ligand 16(CXCL16)/C-X-C chemokine receptor type 6(CXCR6) axis and its regulatory role in the occurrence, development and invasion of breast cancer, and to provide a review of new ideas for molecular biological research and targeted anti-tumor therapy of breast cancer.]]> 2020/7/3 15:01:52 ZHOU Zi-ting, GE Fei, JIANG Ai-mei 241true ［Abstract］　In recent years, the treatment and prevention of myocardial ischemic-reperfusion injury(MIRI) is one of the emerging research topics in the cardiovascular field. Gap junction(GJ) is the basic structure of cardiac electrophysiology. Connexin(Cx) is the basic unit of GJ. Connexin 43(Cx43) is the most abundant member of the Cx family in the heart. The normal expression of Cx43 is essential for cardiac development, the coordination of electrically coupled cardiomyocyte activity and myocardial function. The relationship between Cx43 and MIRI has become the focus of current research. This paper reviews the relationship between Cx43 and myocardial ischemic-reperfusion arrhythmia.]]> 2020/7/3 15:01:52 CHEN Hong-yi, LIANG Yi-lin, HUANG Zhao-he 240true ［Abstract］　Age-related macular degeneration(AMD) is a common senile eye disease that causes blindness. In this paper, we review the research progress of AMD pathogenesis and clinical application of omics techndogy in AMD.]]> 2020/7/3 15:01:52 MA Jing, XU Xin-rong 239true ［Abstract］　Sepsis is a life-threatening organ dysfunction caused by the dysregulation of the body′s response to infections and remains a challenge in emergency and critical care medicine and also is a clinical problem to be solved urgently. Targeted anti-infection treatment as soon as possible after the pathogeny is clear can reduce the mortality, which is the key to the treatment of sepsis. At present, the detection technology of pathogeny is still lacking in timeliness and accuracy. In the diagnosis of pathogenic microorganisms, high-throughput sequencing technology can detect a wide range of species with rapid and accurate characteristics. In recent years, high-throughput sequencing has special advantages on monitoring pathogeny and drug resistance, and is being gradually applied to clinical medicine. In this paper, we review the value of high-throughput sequencing technology in pathogenic diagnosis of sepsis and prediction of drug resistance of pathogenic bacteria.]]> 2020/7/3 15:01:52 HAN Lin, JIANG Ling-yu, HUANG Lu, et al. 238true ［Abstract］　Allogeneic hematopoietic stem cell transplantation(allo-HSCT) is an aggressive and effective treatment for hematological malignancies. Central nervous system graft-versus-host disease(CNS-GVHD) is one of the rare and fierce complications after allo-HSCT. Based on the case reports and studies of CNS-GVHD at home and abroad, we review its pathogenesis, classification, clinical manifestations, diagnosis and treatment in this paper.]]> 2020/6/1 16:44:46 LIN Shang-nao, YU Jian 237true ［Abstract］　Ti-implant is a kind of ideal restore device for tooth loss. The main culprit why many implant surgeries fail lies in bacterial inflammation and poor osseointegration of the hard and soft tissues surrounding the implants. So far, many studies have found that implants equipped with coatings, which are able to curb bacterial attachment and promote proliferation and differentiation of osteoblast, make longer the implants′ duration of service accessible and reduce the failure rate of detal implant. Now there are various coatings in use. In this paper, the mechanism of action and the advantages and disadvantages of antibacterial coatings, osteogenic coatings and antibacterial-osteogenic composite coatings that are reported widely in recent years are summarized respectively.]]> 2020/6/1 16:44:46 LI Ling-li, LI Xiao 236true ［Abstract］　Delayed cerebral ischemia(DCI), as an important cause of neurological impairment after aneurysmal subarachnoid hemorrhage(aSAH), was once understood to be caused only by cerebral vasospasm and some scholars also directly defined DCI as the adverse prognosis of cerebral vasospasm. However, current researches show that the potential pathogenesis of DCI may be more than that. At present, there are more recognized mechanisms: early brain injury, cortical spreading depolarizations, microthrombosis, microvascular spasm, cerebral blood flow autoregulation disorders, oxidative stress and reactive oxygen species free radical production, and other mechanisms, such as cell death, inflammatory response, blood-brain barrier damage, etc. In this paper, we review the research progress in DCI after aSAH.]]> 2020/6/1 16:44:46 LI Xue-feng, WANG Jian-cun, HU Guan-cheng 235true ［Abstract］　With the development and application of artificial intelligence（AI）, AI would be helpful to build a new medical system for the prevention and therapy of cardiovascular diseases. In the domestic clinical practice, the clinical data are too huge and complicated to be analyzed and explored, however AI could work like human brain to learn and think to help clinical practice, based on an efficient computing system. In this paper, we make an introduction of AI and deep learning and review the application of AI in cardiovascular diagnosis and therapy to provide an efficent and accurate novel method of managing cardiovascular diseases.]]> 2020/6/1 16:44:46 XIONG Ri-xin, LIN Ying-zhong 234true ［Abstract］　Nasopharyngeal carcinoma(NPC) has a high incidence rate in South China. Early diagnosis and early therapy can improve the survival rate of NPC patients. Therefore, it is very important to improve the detection rate of early NPC in the population of South China.An important factor causing NPC is that nasopharyngeal epithelial cells are infected by Epstein-Barr virus(EBV). Some genes of EBV express a variety of proteins, such as R transactivator(Rta), Z transactivator(Zta), early antigen(EA), viral capsid antigen(VCA) and EBV nuclear antigen 1(EBNA1). Therefore, the main antibodies including immunoglobulin G(IgG) and immunoglobulin A(IgA) are formed in the serum of human body, among which Rta-IgG, Zta-IgG/IgA, EA-IgA, VCA-IgA and EBNA-IgA/IgG are specific markers of NPC. In this paper, we review the biological characteristics of the related genes and their expressed proteins, as well as the diagnostic value of these serological markers in screening the population in the high incidence area of NPC, so as to provide a basis for early screening of NPC.]]> 2020/4/30 17:42:57 LI Wei, LIU Fei 233true ［Abstract］　The word autophagy comes from Greek, meaning “eating oneself” and “precise cellular action”. It has been nearly 50 years since autophagy was first discovered. It has been found that autophagy can be activated by many stimuli, including hunger, toxins, oxidative stress and infection. Under normal conditions, autophagy of cardiomyocytes is maintained at a low level, but under high activation of stress response, autophagy activity is enhanced and plays an important role in regulating cardiac homeostasis and function. This paper reviews the research progress on the correlation between autophagy and cardiomyopathy.]]> 2020/4/30 17:42:57 SUI Xin, NIU Yu-lin, LI Kun 232true ［Abstract］　Trigeminal neuralgia is one of the common facial pains, but the etiology of trigeminal neuralgia is not clear yet. The theory of vascular oppression is generally accepted currently, and demyelination of nerve fibers is another cause of trigeminal neuralgia. No unified criterion by now leads to the diversity of the treatment methods and the results of treatments, complications and recurrence rates are also different. In this paper, we review the advances in the clinical treatment of trigeminal neuralgia.]]> 2020/4/30 17:42:57 LI Long-long, SHOU Ji-xin 231true ［Abstract］　Some patients receiving laparoscopic surgery often experience shoulder pain after the surgery. Most scholars believe that the shoulder pain is caused by pneumoperitoneum or carbon dioxide(CO₂) which is used to build up pneumoperitoneum forming carbonic acid to stimulate the phrenic nerve. Too high pneumoperitoneum pressure, too much CO₂ left under the diaphragm and too fast CO₂ inflation rate maintaining pneumoperitoneum may cause postoperative shoulder pain. A variety of post-laparoscopic shoulder pain(PLSP) are mainly dull pain, without obvious sites, most of which are mild to moderate pain. There are many measures to prevent and relieve the shoulder pain after laparoscopic surgery, including surgical, pharmaceutical and nursing measures, but the effects of various methods are different. At present, there is not an accepted method with definite effect. In this paper, the occurrence mechanisms, risk factors and methods of relieving PLSP are reviewed.]]> 2020/4/30 17:42:57 LI Jia-xin, ZHAO Zhao, HAN Ya-kun, et al. 230true ［Abstract］　Avascular necrosis of femoral head(ANFH) is a series of physiological and pathological changes induced by blood microcirculation disturbance of femoral head, which eventually leads to diseases of femoral head necrosis. Microcirculation disturbance is the most common cause of ANFH, and improving femoral head microcirculation can promote ANFH repairment and regeneration. Vascular endothelial growth factor(VEGF) gene transfection of bone marrow mesenchymal stem cells has a significant effect in the treatment of ANFH. Forkhead box C2(Foxc2) gene transfection of bone marrow mesenchymal stem cells can promote the differentiation of mesenchymal stem cells and osteogenic precursor cells into osteoblasts after implantation of necrosis of femoral head, so as to repair the necrosis of femoral head. High expression of osteopontin(OPN) gene can promote the proliferation and differentiation of osteoblasts. High expression of p53 gene reduces the generation of osteoblasts but increases the apoptosis, and increase of bcl-2 can inhibit the apoptosis. In this paper, we review the research progress in gene therapy for ANFH.]]> 2020/4/10 18:04:33 WEI Ming-zhao, LI Hong-yu 229true ［Abstract］　As the largest intra-articular fracture of the human body, acetabular fracture is one of the most difficult operations in orthopedic departments because of its deep location, difficult exposure, dense blood vessels and nerves around and the treatment of surgical anatomic reduction and rigid fixation. In this paper, we review the classic approaches and the advances in various approaches to improve acetabular fractures.]]> 2020/4/10 18:04:33 LI Shuo, ZHAO Yang-fei, ZHANG Yu, et al. 228true ［Abstract］　Micro ribonucleic acid-221/222(miR-221/222) is a kind of microRNAs closely related to tumorigenesis. Abnormal expression of miR-221/222 exists in the process of differentiation and development of multi-system, multi-step and multi-site tumors. MicroRNA-221/222 plays the role of tumor suppressor or oncogene through signal transduction pathway targeting different target genes, and is expected to become a biomarker and a novel therapeutic target for malignant tumors. In this paper, we review the research progress on the relationship between miR-221/222 and tumorigenesis and development.]]> 2020/4/10 18:04:33 YANG Meng-meng, CHEN Hong-yue, WU Hong-yuan 227true ［Abstract］　Therapeutic drug monitoring(TDM) is a research hotspot to guide the clinical medications in the field of psychopharmacology in recent years. Individualized and rationalized medications can be achieved through TDM to illuminate the relationship between blood drug concentration, dose, clinical efficacy and adverse reactions. In this paper, we review the research progress in the relationship between blood concentration of new type antidepressants and their clinical efficacy.]]> 2020/4/10 18:04:33 ZHU Jin-fang, CHEN Zhao-ni, LIU Tao-tao, et al. 226true ［Abstract］　Hyperglycemia can lead to the interruption of renal microvascular system, progressive damage of glomerular capillary and tubulointerstitial, and also induce the hypercoagulability of platelet(PLT). PLT plays an important role in diabetes mellitus(DM) and vascular complications by changing its morphology, function and activation state. The correlation between PLT and DM and diabetic nephropathy(DN) is reviewed in this paper.]]> 2020/3/16 15:42:28 CAI Jin-wei, LUO Yan-xia, KUANG Jian 225true ［Abstract］　Acquired immune deficiency syndrome(AIDS) patients, cancer patients, organ transplant recipients and the elderly are at high risk of herpes zoster. Postherpetic neuralgia(PHN) is one of the sequelae of herpes zoster and seriously affects the daily activities of the patients such as work, study, life and entertainment, leading to anxiety, depression, and even suicide. In this paper, we review summarizes the research progress of PHN diagnosis and treatment in recent years.]]> 2020/3/16 15:42:28 XU Bing, CHEN Qi-bo, GUAN Xue-hai 224true ［Abstract］　Chronic kidney diseases(CKD) are common diseases that seriously endanger human health lead to death. Strengthening the prevention and treatment of CKD has become a public health problem that can not be ignored. The pathogenesis of CKD is complex and diverse. Hypoxia inducible factor(HIF) plays an important role in the occurrence and development of CKD and CKD-related complications. HIF is a key nuclear transcription factor that regulates oxygen homeostasis in the body. It participates in the pathological process of renal fibrosis by regulating the transcription of downstream target genes and interacting with multiple signaling pathways. In addition, HIF also plays an important role in the transformation of acute kidney injury(AKI) into CKD. Therefore, targeted studies on HIF and its related signaling pathways have important clinical significance. This paper reviews the pathophysiological characteristics of HIF and its regulatory role in the development of CKD.]]> 2020/3/16 15:42:28 LIU Yi-ran, LIU Dan-dan, ZHANG Hong-xu 223true ［Abstract］　There are tens of thousands of non-coding ribonucleic acid(non-coding RNA,ncRNA) in cells. People′s understanding of ncRNA has changed from the initial transcription junk into functional regulators. Non-coding RNA is involved in mediating cell processes, including chromatin remodeling, transcription and post-transcriptional modification. Non-coding RNA plays a key regulatory role in many diseases, especially in malignant tumors, it can drive specific cellular biological activities as carcinogenic and anti-carcinogenic factors. So far, the etiology of ovarian cancer has not been clearly elucidated. Exploring the role and mechanism of ncRNA in ovarian cancer cells will help to provide new ideas for the study of ovarian cancer. In this paper, we review the studies on ncRNA associated with ovarian cancer, focusing on microRNA(miRNA), long non-coding RNA(lncRNA) and circular RNA(circRNA).]]> 2020/3/16 15:42:28 ZHANG Min, DU Yu-xuan, WANG Yang, et al. 222true ［Abstract］　Metastasis is the basic characteristics and important signs of malignant tumors, and also the primary cause of treatment failure or death of cancer patients.Micro ribonucleic acid(microRNA, miRNA) is a kind of non-coding RNA fragments with regulatory function. It plays an important role in tumorigenesis and development by regulating the transcription and translation of downstream target genes. miRNA plays an important role in the multiple important links in biological behavior of invasion and metastasis of malignant tumors. Elucidating the mechanisms of metastasis regulation of miRNA related to tumor metastasis will provide us with a new perspective on the occurrence and development of tumors and bring about a new breakthrough in the diagnosis and treatment of cancers. In this paper, we review the research progress of the regulation mechanisms in miRNA and tumor metastasis.]]> 2020/2/18 17:19:02 HUANG Yong-ta, MO Xiang-lan 221true ［Abstract］　Spinal cord injury(SCI) is a disease that seriously affects the living ability of patients. SCI is often caused by spinal fractures or structural changes due to traffic accidents, industrial accidents and movement errors resulting in a series of dysfunctions of which dyskinesia is a common symptom after SCI. Early rehabilitation training is beneficial to improving the movement function of the patients, and walking training plays an important role in the rehabilitation of movement function of the patients with SCI. In this paper, we review the characteristics of movement dysfunction caused by different segments of SCI, the timeliness and indications of walking training, and the advances in research on rehabilitation of lower limb dyskinesia caused by SCI via different walking trainings.]]> 2020/2/18 17:19:02 LU Ming-yi, WU Bing-jie, XU Jian-wen, et al. 220true ［Abstract］　Preterm birth, as a leading cause of death in children under five years old, causes severe family and global disease burden. One of the main challenges to prevent preterm birth is to determine the risk factors of preterm birth. In recent years, with the development of sequencing technology, the relationship between preterm birth and microbial community, especially vaginal microbiome, has become a research hotspot. In this paper, the research progress in the association between preterm birth and vaginal microbiome is briefly reviewed.]]> 2020/2/18 17:19:02 ZHANG Xiang-yang, MA Hai-ping, ZHANG Zhu-lan 219true ［Abstract］　Bezold-Jarisch reflex(BJR) is a cardiovascular inhibitory reflex that can cause severe bradycardia, hypotension and peripheral vasodilation. Failure in timely diagnosis and treatment of BJR will affect the patients′ clinical outcomes. At present, the early diagnosis rate of BJR in clinical practice is low and accurate principles of diagnosis and treatment are lacking. In this paper, we review the history, pathophysiological mechanisms, clinical phenomena and treatment measures of BJR.]]> 2020/2/18 17:19:02 XU Qing, GUO Wen-jun 218true ［Abstract］　Plazomicin is a novel aminoglycoside that is chemically synthesized from sisomicin with enhanced activity against most multidrug-resistant pathogens. Similar to other aminoglycosides, plazomicin inhibits protein synthesis by binding to the bacterial 30S ribosomal subunit. Plazomicin is engineered to overcome the most common aminoglycoside-modifying enzymes, but is not active against 16S rRNA methyltransferase. In this paper, we review the chemical structure, antibacterial mechanism, mechanism of drug resistance, antibacterial activity in vitro and in vivo, pharmacokinetics, pharmacodynamics, clinical application and drug compatibility of plazomicin.]]> 2020/12/31 15:05:24 WANG Ya-le, XIE Xiao-qian, ZHAO Ze-yue, et al. 217true ［Abstract］　Thalassemia is a common autosomal monogenic disease in tropical and subtropical areas. In Southern China, especially in Guangdong and Guangxi, it is a high incidence disease. In all types of thalassemia, severe α-thalassemia is a fatal disease. Prenatal diagnosis and genetic counseling are the primary way to prevent the birth of a fetus with severe α-thalassemia. The technology of non-invasive ultrasonic screening is the most frequently used in severe α-thalassemia. There are more valuable ultrasonic indicators for screening severe α-thalassemia like cardiothoracic ratio, middle cerebral artery peak systolic velocity and inner diameter of fetal umbilical vein. However, some fetuses with severe α-thalassemia often show abnormal ultrasound manifestations in late pregnancy. Therefore, it is necessary to search for more sensitive ultrasonic features and indicators to screen severe α-thalassemia fetuses. These ultrasonic features and indicators can find severe α-thalassemia fetuses in pregnancy, reduce the number of the patients who receive invasive examinations and help clinicians to make a decision for termination of abnormal pregnancies timely, and prevent the birth of fetuses with severe α-thalassemia more precisely, which has significances. In this paper, we review the ultrasonic features and indicators related to prenatal screening for severe α-thalassemia.]]> 2020/12/31 15:05:24 ZENG Ni, WAN Li-kai 216true ［Abstract］　Triple-negative breast cancer(TNBC) is a highly heterogeneous breast cancer with unique biological and pathological characteristics different from other types of breast cancer. Its immunohistochemical markers of estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(HER-2) are all negative.Due to the lack of the corresponding hormone receptors and HER-2 expression, up to now, the main early and postoperative treatment of TNBC is neoadjuvant chemotherapy containing anthracyclines and taxanes. However, there is still no effective treatment plan for the patients with recurrence or metastasis of TNBC, so the treatment of TNBC is still a thorny problem in the medical field. In this paper, the research progress in the treatment of TNBC is reviewed.]]> 2020/12/31 15:05:24 WANG Li-zhi, XING Xiao-jing 215true ［Abstract］　Faced with the severe challenges brought about by the low-oxygen environment of a plateau, high altitude populations may have two different manifestations: adaptation and non-adaptation. Among them, those who do not adapt to the plateau will be negatively affected by erythrocytosis, and this group of people may eventually suffer from chronic mountain sickness(CMS) when the time of maladaptation increases. To uncover the reasons for the differences in adaptation and CMS among different populations, researchers have now used genomics techniques and genetic statistics to identify some important genetic molecules, such as genes endothelial PAS domain protein 1(EPAS1) and SUMO-specific protease 1(SENP1), as well as related haplotypes and single-nucleotide polymorphisms(SNPs). Although these genetic molecules do not have sufficient functional verification results for the time being, these findings provide important reference information for understanding the pathological molecular mechanism of CMS.]]> 2020/12/5 0:00:00 ZHANG Han, ZHANG Zhi-ying, LIU Li-jun, et al. 214true ［Abstract］　Obstructive sleep apnea-hypopnea syndrome(OSAHS) is a kind of sleep respiratory disease with sleep snoring, apnea and daytime sleepiness as the main clinical manifestations. This disease has a complex etiology and is very harmful. In this paper, the research progress in the factors influencing sleep quality of OSAHS patients is reviewed.]]> 2020/12/5 15:52:01 RAO Ming-cong, WANG Ling, HUANG Min-fang 213true ［Abstract］　Cervical cancer is one of the most common malignant tumors in clinics. Invasion and metastasis of cervical cancer cells is an important cause of death. The abnormal glycosylation is closely related to the occurrence, invasion, metastasis and immune escape of cervical cancer. In this paper, the possible mechanisms of glycosylation and the occurrence and development of cervical cancer and its related application in the clinical diagnosis and treatment of cervical cancer are reviewed.]]> 2020/12/5 15:52:01 CHEN Ying-ying, ZENG Xiao-mei 212true ［Abstract］　Round spermatid injection(ROSI), a technique by which haploid round spermatids are injected into mature oocytes through microinjection to fertilize the oocytes and then divide them into embryos, is the last hope that non-obstructive azoospermia patients may obtain their own genetic offsprings. Round spermatids, haploid male germ cells, the last stage before spermatogonia undergo meiosis to form sperm, and are collected mainly through testicular sperm aspiration(TESA) or microscopic testicular sperm extraction(Micro-TESE). Although ROSI test-tube babies have been born, the ROSI technology efficiency(pregnancy rate, live birth rate) is generally low, and so far this technology has not been widely implemented at home and abroad. The inaccurate identification of living haploid round spermatids is one of the main reasons for the inefficiency of ROSI. This paper introduces several methods to identify human testis haploid round spermatid.]]> 2020/12/5 15:52:01 MAO Xian-bao, XUE Lin-tao 211true ［Abstract］　Land desertification causes dust weather frequently, which increases the concentration of fine particulate matter(PM) in the atmosphere and causes multi-system damage mainly to the respiratory system, attracting the attention of the government and the public. Dust weather increases the incidence of respiratory diseases, hospitalization rate and causes the corresponding lung function and chest radiograph changes in the population. Animal experiments have confirmed that exposure to PM causes the inflammatory damage of the lung tissues, and the formation of sand pneumoconiosis fibrosis in the chronic stage. At present, it is believed that immune inflammatory response and oxidative stress are the main mechanisms of respiratory system injury caused by dust PM. Therefore, an in-depth study on the respiratory system injury effect of dust PM and its mechanisms provides a theoretical basis for the effective prevention and treatment of human related diseases.]]> 2020/11/3 8:38:30 LI Yi, HOU Yin-huan, SANG Ying-zhu, et al. 210true ［Abstract］　Secondary hyperparathyroidism(SHPT) is one of the common complications of dialysis patients with chronic kidney disease. With the improvement of dialysis methods and techniques, the average life span of the patients is prolonged, and the incidence of SHPT during dialysis is gradually increasing. Some patients with refractory SHPT need surgical treatment. In this paper, we review the postoperative complications related to parathyroidectomy in SHPT patients.]]> 2020/11/3 8:38:30 ZOU Bao-shan, KONG Ling-quan, WU Kai-nan 209true ［Abstract］　Dexmedetomidine(DEX) is a highly selective α₂ adrenergic receptor agonist with a wide range of clinical effects. In this paper, the pharmacological action and organ protective effect of DEX are reviewed, with emphasis on the progress of its clinical application in the protection of nervous system and heart, lung, liver and kidney organs.]]> 2020/11/3 8:38:30 GONG Zheng, WEI Hui-jun, LI Jun, et al. 208true ［Abstract］　Cardiopulmonary bypass technique is the guarantee condition of cardiac surgery. Cardiopulmonary bypass provides a relatively bloodless surgical field for the surgeons, and also reduces the visceral blood flow of the patients, and leads to systemic inflammation caused by ischemia and hypoxia of important organs, among which liver injury cannot be ignored. This paper reviews risk factors related to perioperative liver injury during cardiopulmonary bypass to find out the best solution to reduce liver injury.]]> 2021/9/30 20:36:23 FU Jia-yu, GAO Shun, CHE Yan, et al. 207true ［Abstract］　Non-coding ribonucleic acids(ncRNAs) play an important role in human normal physiological processes and diseases. ncRNAs have been proved to be involved in the regulation of various inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis. Gout is a common inflammatory joint disease. In this paper, the current research progress of ncRNAs in gout is reviewed. Micro ribonucleic acids(miRNAs) and long non-coding ribonucleic acids(lncRNAs) may play a role in regulating the pathogenesis of gout through a variety of pathways. Targeting ncRNAs may be an effective strategy for the treatment of gout.]]> 2021/9/30 20:36:23 JIANG Ya-qiong, YANG Li-hua, MA Fu-cai, et al. 206true ［Abstract］　Secondary hyperparathyroidism(SHPT) is a common complication in patients with end-stage chronic kidney disease, and the incidence of SHPT is relatively high. Patients with advanced SHPT often develop drug resistance and need parathyroidectomy. Surgery can significantly relieve the symptoms of SHPT patients, such as bone pain and skin itching, improve the physical and mental health, improve the quality of life, and reduce the mortality of SHPT patients. The main surgical methods of SHPT include total parathyroidectomy, subtotal parathyroidectomy and total parathyroidectomy+autotransplantation, but there is no consensus on the choice of various surgical methods. This paper reviews the current status of surgical treatment of SHPT through consulting the literature at home and abroad.]]> 2021/9/30 20:36:23 CHEN Yuan-yuan, LIANG Bin, DONG Xiao-feng, et al. 205true ［Abstract］　Invasive micropapillary carcinoma(IMPC) is a rare subtype of breast cancer, accounting for 3.0%-8.0% of breast cancer. Therefore, IMPC still faces some problems in clinical practice. In view of its high vascular invasion rate, high lymph node metastasis rate and higher local recurrence rate, more and more scholars are exploring its pathological mechanisms, diagnosis methods and treatment options. This paper reviews the clinicopathological features and the factors related to the prognosis of IMPC in breast.]]> 2021/9/30 20:36:23 LI Qiu-yun, QIN Yan, YANG Hua-wei 204true ［Abstract］　Toll-like receptors(TLRs) can recognize many types of pathogen-related molecular patterns, and their mediated signal transductions play an important role in inflammatory response. Type 1 diabetes mellitus(T1DM) is caused by the autoimmune destruction of islet β cells. More and more studies have been observed that the changes of TLRs in T1DM. Abnormal TLRs signal transduction pathways change immune homeostasis and cause pathological damage of the pancreas, leading to autoimmune response. In this paper, the structure and signal transduction pathways of TLRs and their relationships with T1DM are reviewed.]]> 2021/9/4 10:38:09 CHEN Huan-huan, SONG Chao-jie, TANG Cong, et al. 203true ［Abstract］　In recent years, the global prevalence of non-tuberculous mycobacterial pulmonary disease has shown an upward trend. Non-tuberculous mycobacterial pulmonary disease has become a common disease and poses a threat to human health. Non-tuberculous mycobacteria(NTM) mainly involves the lung, and non-tuberculous mycobacterial pulmonary disease lacks specific clinical symptoms and signs, and it is difficult to distinguish it from other diseases. Many clinicians often neglect the existence of non-tuberculous mycobacterial pulmonary disease, which often leads to misdiagnosis or missed diagnosis. This paper reviews the definition, epidemiology and risk factors, pathogenesis and pathological changes, diagnosis, treatment and prevention of non-tuberculous mycobacterial pulmonary disease.]]> 2021/9/4 10:38:09 JIN Cong, WANG Zhen-shan 202true ［Abstract］　Magnesium is one of the important cations in the human body, and plays not only an important role in human metabolism and nerve conduction, but also a key role in regulating the biochemical changes of the brain. Serum magnesium level can affect several neural conduction pathways related to the development of depression.When the body is deficient in magnesium, a series of personality changes can occur, including indifference, depression, irritability, confusion, anxiety and insanity. Magnesium supplementation can improve depression state and alleviate anxiety, but the specific mechanisms of how serum magnesium level affects the patients′ emotions remain unclear. In this paper, the research progress in the relevant mechanisms between serum magnesium level and depression is reviewed.]]> 2021/9/4 10:38:09 YUAN Bo, DING Ya-meng, ZHANG Heng-fei, et al. 201true ［Abstract］　In-vivo confocal microscopy(IVCM) can detect the morphological structure of corneal tissues and cells of each layer in a rapid, non-invasive and high-resolution manner, which is crucial in the diagnosis of corneal lesions. The incidence of diabetes is getting higher and higher, and its serious complications not only affect the patients′ quality of life, but also increase the financial burden on the families and society. Diabetic ocular complications include diabetic retinopathy, cataract and corneal diseases. In this paper, we review the research progress of IVCM in detecting corneal lesions in diabetic patients.]]> 2021/9/4 10:38:09 CHEN Li-fei, HUANG Hui, CHEN Qi, et al. 200true ［Abstract］　Angiotensin Ⅱ type-2 receptor(AT2R) is a renin-angiotensin system(RAS) receptor that has not been fully revealed. In recent years, scholars have paid more and more attention to the potential of AT2R in clinical application. At the same time, AT2R is also one of the key damage factors of coronavirus disease 2019(COVID-19). In this paper, the advances in discovery, development and clinical application of AT2R are reviewed to provide ideas for clinical indications.]]> 2021/8/6 11:16:11 WU Zi-meng, LUO Yi-feng, LI Qian, et al. 199true ［Abstract］　Meteorin-like protein(Metrnl), as a new adipokine, is widely distributed in human body. Myocardial ischemia-reperfusion injury(MIRI) caused by revascularization after myocardial ischemia seriously affects the prognosis of patients with acute myocardial infarction(AMI), and Metrnl is closely related to the improvement of MIRI. This paper reviews the research progress of the relationship between Metrnl and MIRI.]]> 2021/8/6 11:16:11 MI Yong-cheng, HUANG Zhao-he 198true ［Abstract］　Spinal muscular atrophy(SMA) is a common autosomal recessive hereditary disease of the neuromuscular system, and the survival motor neuron 1(SMN1) gene is its pathogenic gene. At present, a number of studies have shown that SMA is a disease involving multiple systems, including the cardiovascular system, the digestive system, the metabolic system and the genitourinary system besides the neuromuscular system. The fact that the patients with the diversity of clinical manifestations and the same pathogenic mutations indicates that there were genetic and environmental modifying factors, such as the copy number of survival motor neuron 2, the copy number of neuronal apoptosis inhibitory protein, the over expressions of zinc finger protein 1 and plastin 3 protein, and down-regulation of neurocalcin delta protein, which all can modify the phenotypes. It can provide reference for genetic counseling and prognosis evaluation, and can be used as new therapeutic targets. In this paper, the research progress of the multi-system involvement of SMA and modifier genes is reviewed.]]> 2021/8/6 11:16:11 WU Xia, LI Mei 197true ［Abstract］　Metabolic associated fatty liver disease(MAFLD) is a group of highly heterogeneous diseases closely related to metabolic dysfunction, while metabolic syndrome is a group of syndrome with central obesity, dyslipidemia, hypertension, diabetes, or impaired glucose tolerance. MAFLD is generally considered to be the hepatic manifestation of metabolic syndrome, and insulin resistance is considered to be the key link between MAFLD and metabolic syndrome. The change in the prevalence rate of MAFLD is parallel to the epidemic trend of metabolic syndrome, and the prevalence rate continues to increase in an upward trend, and they make cause and effect each other, leading to the occurrence of metabolic, cardiovascular and hepatic complications. Lifestyle intervention is the cornerstone of its prevention and treatment, and multidisciplinary collaboration is a new model for management of patients with MAFLD and metabolic syndrome in the future. This paper reviews the research progress in the relationship between MAFLD and metabolic syndrome.]]> 2021/8/6 11:16:11 CAI Lian-ying, WANG Wen-juan, LIANG Yun-xiao, et al. 196true ［Abstract］　Patients with gastric varices(GV) are prone to bleeding, and have a high mortality. The current treatments of GV have not been standardized. Although endoscopic injection of tissue adhesives is the most widely used therapy for GV, it is associated with various complications, including ectopic embolism and recurring hemorrhage. Recently, the treatment of GV under the guidance of endoscopic ultrasonography(EUS) has become a promising new method with relatively high technology and clinical success rate, and low recurrence rate, and it is worthy of clinical application. In this paper, we mainly review the etiology, classification and treatment options of GV, especially the emerging endoscopic intervention.]]> 2021/7/5 12:12:34 ZHOU Qing-nan, GUO Xian-wen, ZHANG Guo, et al. 195true ［Abstract］　Clonorchiasis is a kind of food-borne parasitic diseases with great harmfulness. There are about 35 million people infected with liver flukes in the world, and about 1.1 billion people are at risk of infection. Cholangiocarcinoma(CCA) is the most serious complication caused by long-term infection of liver flukes. Therefore, World Health Organization International Cancer Research Agency has listed liver flukes as a class Ⅰ carcinogenic pathogen of CCA. In recent years, many scholars have done the corresponding clinical and experimental studies on the carcinogenic mechanisms of liver flukes infection, but so far their carcinogenic mechanisms are not very clear. In this paper, we review the pathogenesis of CCA caused by liver flukes.]]> 2021/7/5 12:12:34 XIE Hong-dan, CAO Cong 194true ［Abstract］　Ultrasound-guided fine-needle aspiration cytology(US-FNAC) is currently recognized as the first choice for preoperative differentiation of benign and malignant thyroid nodules. Due to the limitations of cytological diagnosis and other factors, 20% to 30% of the nodules cannot be definitively diagnosed. In recent years, the domestic and foreign literature has reported that the combination of US-FNAC with other diagnostic methods can further improve the diagnostic efficiency. This paper reviews the research progress of US-FNAC combined with gene detection, contrast-enhanced ultrasound and elastography in diagnosis of thyroid nodules.]]> 2021/7/5 12:12:34 YU Lu-lu, LIU Li-ping 193true ［Abstract］　Obstructive sleep apnea syndrome(OSAS) has been repeatedly recognized as an important independent risk factor of coronary heart disease(CHD), affecting the occurrence and development of CHD. The mechanisms are not fully understood, and may be related to intermittent hypoxia, sympathetic nerve activation, oxidative stress, hypercoagulability, inflammatory response, endothelial dysfunction and metabolic abnormalities. Whether continuous positive airway pressure(CPAP) has a positive effect on CHD remains controversial. In this paper, the key aspects of the classification and diagnosis of OSAS are summarized, and the possible mechanisms of OSAS involving in CHD are mainly discussed; the current evidence of the effect of CPAP on CHD is reviewed, and the prospects for the treatment of patients with CHD complicated with OSAS are proposed.]]> 2021/6/3 21:44:38 ZHANG Xi, HUANG Bing, WANG Gui-peng 192true ［Abstract］　Cough dysfunction is a common complication after stroke, leading to an increased risk of pneumonia and a poor prognosis. By understanding the risk factors associated with cough dysfunction after stroke, it is of great significance to take effective intervention measures for high-risk patients early. In this paper, the risk factors of cough dysfunction after stroke, the correlation between cough function and the risk of pneumonia and respiratory dysfunction, and the common rehabilitation treatment measures are reviewed.]]> 2021/6/3 21:44:38 LI Yi, YU He-ping 191true ［Abstract］　Lidocaine is an intermediate-acting local anesthetic with amino amide structure and is a sodium channel blocker. In addition to local anesthesia, regional anesthesia and antiarrhythmic treatment, lidocaine is widely used in clinical practice. In this paper, the clinical applications of lidocaine and their brief mechanisms are reviewed.]]> 2021/6/3 21:44:38 SHOU Yun-feng, LI Yuan-tao 190true ［Abstract］　High mobility group box-1(HMGB1) is a nuclear protein, which exists in the nuclei of almost all cells. It can regulate chromatin structure, DNA replication and gene transcription. It is essential for the normal development of cells. HMGB1 plays an important role in mediating the inflammatory response when it is released from the inside of cells to the outside of cells as a damage-related molecular pattern. Myocardial ischemia-reperfusion injury is a pathophysiological process in which a variety of cells and cytokines participate, and the signal molecules and pathways involved are extremely complex. With the development of molecular biology of diseases, studies have found that HMGB1 plays a key role in myocardial ischemia-reperfusion injury. Elucidating the role of HMGB1 in myocardial ischemia-reperfusion injury help us to explore new therapeutic targets. In this paper, the research progress of HMGB1 in myocardial ischemia-reperfusion injury is reviewed.]]> 2021/5/8 18:36:31 TANG Sen-hu, HUANG Zhao-he 189true ［Abstract］　Due to the severe shortage of donor livers, more and more extended criteria donor livers in organ donation after citizens′ death are applying to clinical practice. Machine perfusion(MP) can preserve the isolated livers better than traditional static cold storage(SCS). In this paper, the progress of the study on the clinical application of MP preservation of donor livers is reviewed.]]> 2021/5/8 18:36:31 HUANG Xiao-chun, LAI Yan-hua 188true ［Abstract］　Unhealthy weight control behaviors, such as strict restrictions of food intake, strenuous exercise, anorexia nervosa and use of diet pills are common causes of underweight in young people. However, underweight affects the level of leptin in the body, which interferes with the synthesis of sex hormones through the hypothalamic-pituitary-gonadal axis, thus reducing female reproductive ability and eventually leading to infertility. To solve the problem of underweight, multidisciplinary treatment is often needed, including nutritional support, psychological counseling and drug therapy.]]> 2021/5/8 18:36:31 CHE De-hui, XIAO Zhi-bo 187true ［Abstract］　Metformin is one of the most widely used oral glucose-lowering drugs in the treatment of type 2 diabetes mellitus(T2DM). It has a good curative effect on diabetes, and has relatively high safety and health economic benefits. In addition to the hypoglycemic effect, metformin also plays a role in cardiovascular disease and complications, chronic renal insufficiency, polycystic ovary syndrome and tumor, and the effects and mechanisms of metformin of these diseases are gradually being elucidated. In this paper, the research progress in multipotent pharmacological action of metformin is reviewed to provide evidence for the new clinical applications of the drug.]]> 2021/5/8 18:36:31 YANG Zhou-sheng, CHEN Xiao-yu 186true ［Abstract］　Minimal change disease(MCD) is considered to be a kind of podocytopathy, with a predominant clinical manifestation of nephrotic syndrome. Rituximab(RTX), a human-mouse chimeric monoclonal antibody, is currently administered in the treatment of immune-mediated renal diseases, and has achieved certain curative effect. In recent years, the research of RTX in the treatment of MCD patients has made some progress, which enriches the treatment options of MCD patients. In this paper, we review the current application progress of RTX in MCD patients.]]> 2021/4/2 14:58:35 TIAN Jing-wei, ZHUO li 185true ［Abstract］　Lung transplantation is currently recognized as an effective treatment for end-stage lung disease in the world. With the rapid development of lung transplantation, the survival rate and quality of life of lung transplant patients after surgery have improved significantly. Lung infections are not only the most common complication after lung transplantation, but also the most common cause of death after surgery, among which bacterial infections are the most common. Infections after lung transplantation also cause an increase in the patients′ mortality. In this paper, the current situation of bacterial infections after lung transplantation, the source of pathogens, the risk factors of infections, the progress in diagnosis, prevention and treatment are reviewed.]]> 2021/4/2 14:58:35 LI Rui, WANG Dong-kun, RUAN Chi-yi, et al. 184true ［Abstract］　Cochlear implant(CI) has been the most effective way to obtain hearing for patients with severe and very severe sensorineural hearing loss since its clinical application. However, a small number of patients with congenital deafness have not achieved satisfactory postoperative hearing improvement after CI despite receiving hearing and speech function training. In recent years, with the development of gene detection technology, preliminary results have been achieved in the study of deafness gene as the etiology of congenital deafness patients, and its influence on postoperative efficacy of CI has also been widely studied. In this paper, the correlation between deafness gene mutation and the postoperative efficacy of CI is reviewed.]]> 2021/4/2 14:58:35 HUANG Lan-cheng, ZHOU Kai, FENG Meng-long, et al. 183true ［Abstract］　Parenteral nutrition can provide essential nutrients to improve the clinical outcomes of the patients who cannot obtain nutrition from the gastrointestinal tract. In this paper, we review the research progress in the parenteral nutrition formula analysis and the construction of institutional repository.]]> 2021/4/2 14:58:35 HE Ying, LIANG Yu-hong, YANG Zhi-jie, et al. 182true ［Abstract］　Receptor for advanced glycation end products(RAGE), a member of the immunoglobulin superfamily transmembrane proteins with multiple ligands, is involved in the pathogenesis of a variety of diseases, including Alzheimer′s disease a neurodegenerative disease, diabetes complications, and many diseases related to aging and inflammation. RAGE also plays a key role in regulating the innate immune response. RAGE and its ligands are not only important factors in various inflammatory reactions but also express RAGE in bone marrow mesenchymal stem cells, osteoblasts and osteoclasts. In recent years, the role of RAGE and its ligands in the process of osteoblast and osteoclast proliferations and differentiations, chondrocyte development and bone remodeling has been gradually recognized. In this paper, we mainly review the effects of RAGE and its ligands on bone metabolism and the mechanisms, in order to reveal the regulatory mechanisms of chronic inflammation-related bone loss and bone remodeling, and provide new ideas for the treatment of metabolic bone diseases.]]> 2021/3/5 17:41:47 LIU Xiao-hui, CUI Shun 181true ［Abstract］　Coronary heart disease(CHD) is a disease with high morbidity and mortality, and depression has now been proven to be an independent risk factor for the occurrence and poor prognosis of CHD. Both of them can cause comorbidity, and affect each other, making the patient′s condition deteriorate together. CHD complicated with depression is a common disease in psycho-cardiology. In this paper, the pathogenic features, comorbidity mechanism, early screening, and evaluation and treatment of CHD complicated with depression are reviewed.]]> 2021/3/5 17:41:47 LIU An-bang, MA Huan, GENG Qing-shan 180true ［Abstract］　Spinal and epidural labor analgesia is currently recognized as an effective technique for labor analgesia and is widely accepted. However, whether it has an adverse effect on the birth process remains controversial. Searching for a more optimized protocol to provide safer and more effective analgesia for parturients is still the goal of anesthesiologists. In this paper, we review the recent related clinical studies on the effect of spinal and epidural labor analgesia on birth process and mainly elaborate the impacts of different spinal and epidural labor analgesia techniques, drug concentrations, timing of administration and drug delivery modes on birth process. Besides, we explore the possible mechanism of how spinal and epidural labor analgesia affects the birth process so as to provide a reference for further related researches on spinal and epidural labor analgesia.]]> 2021/3/5 17:41:47 JIA Li, CHEN Dai-li,LI Yuan-tao 179true ［Abstract］　The incidence of female breast diseases has been increasing year after year, Breast cancer has become the most common malignant tumor among Chinese women. The differential diagnosis of benign and malignant solid breast masses is always the key and difficult point in medical imaging research. Contrast-enhanced ultrasound(CEUS) can display the small blood vessels with low velocity and low flow in solid tumors and make real-time dynamic evaluation, thus improving the accuracy of the diagnosis and differentiation of benign and malignant breast masses. The application value of contrast-enhanced ultrasound in diagnosis of benign and malignant breast masses is reviewed in this paper.]]> 2021/3/5 17:41:47 HE Yan, WANG Xiao-yan 178true ［Abstract］　Gitelman syndrome(GS) is a relatively rare autosomal recessive inherited disease. It mainly expresses the sodium-potassium pump protein SLC12A3 gene mutation, resulting in the change of encoded protein and causing disease. GS is mainly manifested as symptoms of hypokalemia and metabolic alkalosis, in which hypomagnesaemia and hypocalciuria are the most valuable in diagnosis. In addition to SLC12A3 gene mutation, recent studies have found that CLCNKB gene mutation and autoimmune diseases may lead to GS. There are many mutation sites and types in SLC12A3 gene, which leads to obvious individual differences in genetics, clinical manifestations and biochemical indexes in GS patients. In this paper, we review the epidemiology, etiology, influencing factors of phenotype, diagnosis and treatment of GS, in order to improve the level of diagnosis and treatment of the disease.]]> 2021/2/3 9:17:59 ZHAI Zhen-wei, LU Wen-sheng 177true ［Abstract］　There are some certain damages to the blood during the perioperative period of cardiopulmonary bypass(CPB), which may lead to abnormal blood coagulation after the operation, and endanger the life of the patients. Moreover, it is difficult to determine the exact causes and mechanisms of the occurrence. Therefore, it is of great clinical value and significance to actively search for the causes and mechanisms of coagulation dysfunction during the perioperative period of CPB for the rehabilitation of the patients after cardiac surgery. In this paper, we review the research progress of coagulopathy during perioperative period of CPB.]]> 2021/2/3 9:17:59 YIN Shi-jie, HUANG Hai-qing 176true ［Abstract］　Spinal eosinophilic granuloma(EG) accounts for less than 1% of all bone tumors. It is a self-limiting disease, and the clinical manifestations of the patients are lack of specificity. It often shows osteolytic changes involving the vertebral body, and is more common in children than in adults. The first symptom is mostly local pain. If the cervical spine is involved, torticollis and activity limitation can be accompanied. If the lesion involves spinal cord or nerve root, it may lead to neurological damage. The characteristic imaging manifestation is a flat vertebra. The pathological feature is a large number of Langerhans cell hyperplasia with eosinophil and lymphocyte infiltration in the lesion tissue. The cervical spine is a rare site of spinal EG. Adult cervical EG mostly involves a single vertebral body, and a small part involves multiple vertebral bodies. Neck pain, limb weakness and movement restriction are the most common symptoms of adult cervical EG. With the deepening of research on spinal EG, the treatments of adult cervical EG are also constantly updated, and surgery is usually performed in the patients with severe neurological deficits and bone instability.]]> 2021/2/3 9:17:59 ZHANG Yu, YU Cheng-qiang, WU You-cai, et al. 175true ［Abstract］　Severe acute respiratory syndrome(SARS), Middle East respiratory syndrome(MERS) and 2019 corona virus disease(COVID-19) caused by three kinds of β-coronavirus infections have similarities and differences in clinical characteristics and organ damage. To summarize and compare their characteristics is helpful to explore the clinical diagnosis, treatment and epidemic prevention and control of COVID-19. Timely assessment of the progression of acute lung injury, prevention of acute respiratory distress syndrome(ARDS) and multiple organ dysfunction are of great clinical significance for the prevention and treatment of COVID-19.]]> 2021/2/3 9:17:59 LUO Ya-li, WANG Bi-wen, AN Fang-yu, et al. 174true ［Abstract］　Depth of anesthesia(DOA) monitoring is one of the key concerns in clinical anesthesia. Good DOA monitoring is helpful to stabilize intraoperative hemodynamics, reduce anesthetic dosage, shorten postoperative recovery time, and reduce the incidence of intraoperative adverse reactions and postoperative complications. In recent years, with the progress of science and technology, various DOA monitoring methods have been widely used in clinical anesthesia, such as bispectral index(BIS), auditory evoked potentials, Narcotrend index, entropy index, index of consciousness and anesthesia consciousness index(Ai), among which Ai is a new DOA monitoring indicator independently developed in China. This paper reviews the research progress of Ai in clinical depth of anesthesia monitoring, providing evidence for the future application of Ai in clinical anesthesia.]]> 2022/1/6 12:24:24 ZHANG Ya-ni, YAN Wen-jun 173true ［Abstract］　Insomnia disorder is closely related to stress and mood, which is one of the common sleep disorders. Insomnia disorder can cause disorders of gut microbiota, and gut microbiota can affect the host behavior through the gut-brain axis immunity, neuroendocrine and vagus nerve pathways. Gut microbiota can cause insomnia disorder by participating in the regulation of the gamma-amino butyric acid(GABA) system, activating the hypothalamic-pituitary-adrenal axis, and affecting the circadian rhythm. This paper reviews the possible pathogenesis of gut microbiota in the occurrence and development of insomnia disorder.]]> 2022/1/6 12:24:24 FAN Xiao-xuan, ZHAO Bin, ZHANG Qing-qing, et al. 172true ［Abstract］　Elevated level of low-density lipoprotein cholesterol(LDL-C) is an important risk factor for atherosclerosis, and lowering LDL-C level can effectively reduce the risk of cardiovascular and cerebrovascular diseases. Proprotein convertase subtilisin/kexin type 9(PCSK9) inhibitors have been shown to improve the prognosis of patients with cardiovascular disease and are widely used for the treatment of coronary atherosclerotic heart disease at acute phase or its secondary prevention in clinical practice. However, its application in ischemic stroke and its impact on stroke prognosis are rarely reported at present. This paper reviews the research progress in the application of PCSK9 inhibitors in ischemic stroke.]]> 2022/1/6 12:24:24 TIAN Xiao-bing, ZHANG Nan 171true ［Abstract］　Sepsis and septic shock are important clinical problems in emergency and critical care medicine. The morbidity and the mortality of septic shock in critically ill patients are very high. Venous-to-arterial carbon dioxide partial pressure difference［P(v-a)CO₂］ is closely related to the guidance of fluid resuscitation in septic shock, to the assessment of tissue oxygen supply and demand, and to the assessment of critical condition and the patients′ prognoses. In this paper, we review the research progress of the application of P(v-a)CO₂ in guiding the evaluation for treatment of septic shock.]]> 2022/1/6 12:24:24 LIN Xue-zhen, HUANG Zhai 170true ［Abstract］　Skeletal class Ⅱ malocclusion is a common malocclusion in adolescence. The effect of orthodontic treatment is closely related to the growth potential of the adolescents and the severity of their skeletal discrepancy. The characteristics and orthodontic treatment methods of skeletal class Ⅱ malocclusion, the craniomaxillofacial features recommended for orthodontic treatment in combination with orthognathic surgery, the limit of tooth movement and the characteristics of soft tissue changes in adolescents are reviewed in this paper, so as to better provide the basis for clinical selection of orthodontic treatment cases in adolescents with skeletal class Ⅱ malocclusion and the prediction of correction effect before treatment.]]> 2021/12/3 11:58:04 TAN Sheng-huan, ZHONG Rong-bin, HUANG Min-fang 169true ［Abstract］　Autism spectrum disorders(ASD) is a group of neurodevelopmental disorders with different degrees of social communication disorders, narrow interests, stereotyped and repetitive behaviors, and sensory and perceptual abnormalities as the main clinical manifestations. The incidence of ASD has been increasing rapidly in recent years. The etiology of ASD is unknown, and there is currently no specific drug therapy for the core symptoms of ASD. Special education intervention training can improve the symptoms of children with ASD and shorten the gap with normal children. This paper reviews the commonly used methods of ASD education intervention training in recent years.]]> 2021/12/3 11:58:04 LI Ai-wen, ZENG Ting 168true ［Abstract］　Endometriosis(ES), manifested as pelvic pain, infertility or adnexa mass, is a clinically common female disease. ES has always been considered as a potential risk factor for the development of endometriosis-associated ovarian cancer(EAOC), and EAOC is a subgroup of epithelial ovarian cancer(EOC), mainly including endometriosis-like and clear cell types. At present, the risk factors and pathogenesis of EAOC are still not completely clear. This paper reviews the research progress in the pathogenesis and targeted therapy of EAOC.]]> 2021/12/3 11:58:04 ZHAO Jing, ZHANG Qin, LIU Jian, et al. 167true ［Abstract］　Multi-vessel coronary artery disease(MVD) is a more serious type of coronary heart disease, and diabetes mellitus can affect the patency rate after different revascularizations and the risk and severity of perioperative related complications. When MVD complicated with diabetes mellitus occurs, the overall prognosis is very uncertain. This paper reviews the research progress of different treatment options for patients with MVD complicated with diabetes mellitus.]]> 2021/12/3 11:58:04 MENG Xiang-yu, GAO Shun, SHEN Chun-jian 166true ［Abstract］　Ultrasonic examination is a safe, effective, cheap and widely used diagnostic tool. The emergence of high intensity focused ultrasound(HIFU) makes therapeutic ultrasound a reality. At present, HIFU has been widely used to treat benign and malignant lesions of various solid organs and has provided a new treatment choice for patients who reject or are not suitable for surgery. In this paper, we review the research progresses of the treatment principles, application modes and usual and potential clinical applications of HIFU.]]> 2021/11/2 15:11:32 FU Xiao-feng, SI Xing, ZHU Jiang 165true ［Abstract］　Nasopharyngeal carcinoma is a malignant tumor originating from nasopharyngeal epithelium, and the microenvironment of nasopharyngeal carcinoma is the key factor affecting its growth and metastasis. A large number of functional proteins, mRNA, miRNA, DNA fragments and other bioactive substances carried by exosomes in the microenvironment can regulate the migration, invasion and angiogenesis of tumor cells through different mechanisms of action, and can also affect the hypoxic environment of tumors. Therefore, exploring the important exosomes and their signaling pathway mechanisms in microenvironment is of great value to understand the treatment and prognosis evaluation of nasopharyngeal carcinoma. This paper reviews the related exosomes of nasopharyngeal carcinoma microenvironment and research progress of their mechanisms in regulating tumors through different modes of action.]]> 2021/11/2 15:11:32 ZHONG Yu-xiao, HAO Yan-rong 164true ［Abstract］　Both type 2 diabetes mellitus and thyroid nodules are common endocrine and metabolic diseases. In recent years, studies have shown that the incidence of thyroid nodules is relatively high in type 2 diabetes mellitus patients. Analysis of risk factors for thyroid nodules in type 2 diabetes mellitus patients shows that there is a close relationship between thyroid nodules and type 2 diabetes mellitus.This paper reviews the research progress of the relationship between type 2 diabetes mellitus and thyroid nodules in recent 5 years.]]> 2021/11/2 15:11:32 CHEN Ming-ming, WANG Mei 163true ［Abstract］　Cognitive dysfunction is a kind of syndrome caused by many reasons, with the impairment of learning ability and knowledge application ability as the main clinical manifestations. At the same time, it is accompanied by emotional and mental behavior abnormalities, which seriously harms the health of middle-aged and elderly people. Cognitive dysfunction caused by cerebrovascular disease or risk factors of cerebrovascular disease is called vascular cognitive impairment(VCI). Studies have shown that atherosclerosis is one of the main risk factors of VCI. This paper reviews the correlation between atherosclerosis and VCI, the pathological mechanism, treatment and prevention of VCI.]]> 2021/11/2 15:11:32 SONG Xin-yu, SONG Jun-quan, HU Le 162true ［Abstract］　Cardiac surgery under cardiopulmonary bypass(CPB) may impair the central nervous function, which causes postoperative cognitive dysfunction(POCD) and affects the early postoperative recovery and prognosis of the patients. This paper reviews the high risk factors, pathogenesis, prevention and treatment measures of brain injury after cardiac sugery under CPB.]]> 2022/9/30 11:37:10 XIE Jie-lin, CHE Yan, SHEN Chun-jian 161true ［Abstract］　Chronic kidney disease(CKD) has a high incidence rate and great harm to human health, and early detection and intervention of its risk factors are crucial for its treatment. Hyperuricemia is a common complication and comorbidity of CKD. Hyperuricemia is not only the result of renal function decline, but also a risk factor for the deterioration and progression of renal function. In this paper, we review the effect of hyperuricemia on the development and progression of CKD, the pathogenic mechanisms, and the effect of uric acid-lowering therapy on the occurrence of CKD.]]> 2022/9/30 11:37:10 LAN Shu-zhen, ZHOU En-chao 160true ［Abstract］　Standardized application of early essential newborn care(EENC) technology can effectively improve the prognosis of mothers and their infants. This paper reviews the significance and role of the application of EENC technology, and its development and application status in China, and puts forward some thoughts and prospects.]]> 2022/9/30 11:37:10 LIANG Ying-fu, HUANG Fang, LIANG Chun-yan, et al. 159true ［Abstract］　The threat of metabolic-associated fatty liver disease(MAFLD) to human health cannot be ignored. There are many discussions about the pathogenesis of MAFLD in modern medicine. In this paper, we review the pathogenesis of MAFLD and its relationship with intestinal fungal community, and discuss the mechanisms by which the intestinal fungal community may influence the disease progression. Strategies to control the intestinal fungal community may be developed to treat or prevent liver disease.]]> 2022/9/1 11:53:33 XIE Jiao-jiao, WANG Li, HE Yan-fang, et al. 158true ［Abstract］　Mesenchymal stem cells(MSCs) have the function of multi-directional differentiation and paracrine bioactive factors. Therefore, they play important roles in immune regulation, anti-inflammation, angiogenesis and anti-apoptosis, and have been widely used in clinical cell therapy. MSCs-derived exosomes can not only carry the genetic information of MSCs, but also store and maintain the function of MSCs more easily than MSCs, which is beneficial to the repair and regeneration of various tissues after injury. In this paper, the biological characteristics and function of MSCs and their exosomes, and the roles of the exosomes of MSCs in different diseases and their mechanisms are reviewed.]]> 2022/9/1 11:53:33 YU Jing, XU Li 157true ［Abstract］　Hemoglobinopathy is the most common genetic disease in southern parts of China. The clinical manifestations of the disease vary from no phenotype to varying degrees of anemia, and the patients with severe types of hemoglobinopathy need blood transfusion or severe types of hemoglobinopathy can lead to fetal abortion and stillbirth during pregnancy. Glycosylated hemoglobin(HbA_1c) is an indicator reflecting the level of glycemic control in the past 2-3 months. It is widely used in clinical practice as an indicator for screening diabetes mellitus and blood glucose control. In recent years, a number of studies have showed that hemoglobinopathy interferes with the detection value of HbA_1c, which is related to the adopted methodology. In addition, studies have showed that the detection mode of HbA_1c by capillary electrophoresis is a new screening method for hemoglobinopathy. This paper reviews the effect of hemoglobinopathy on the determination results of HbA_1c.]]> 2022/9/1 11:53:33 LI You-qiong, TIAN Mao 156true ［Abstract］　Vascular intimal hyperplasia is the basic pathophysiological feature of a variety of vascular proliferative diseases, and chronic stress may lead to vascular intimal hyperplasia.In recent years, the role of chronic stress in vascular intimal hyperplasia and the studies of vascular intimal hyperplasia caused by cathepsin S(CatS) and cathepsin K(CatK) related signaling pathways have been increasing, and the relationship between chronic stress and vascular intimal hyperplasia has attracted more and more attention. This paper reviews the research progress on the role of chronic stress in vascular intimal hyperplasia and its molecular mechanism.]]> 2022/7/30 18:40:22 WANG Zheng, LI Xiang 155true ［Abstract］　Tumor metastasis-associated gene(MTA) is a gene family related to tumor progression, of which MTA1 is one of the main members. It is abnormally expressed in a variety of tumors, which is closely related to tumor invasion, metastasis and prognosis, and has important clinical research value. This paper reviews the structure and function of MTA1 and its research progress in gynecological malignant tumors.]]> 2022/7/30 18:40:22 SONG Zhen, JIN Ping 154true ［Abstract］　Total hip or knee arthroplasty is an effective way to treat end-stage hip or knee diseases. Postoperative nausea and vomiting(PONV) is one of the most common side effects after total hip or knee arthroplasty, and significantly reduces the postoperative satisfaction of the patients and increases the risk of complications, and caused the prolonged hospital stay of the patients. In this paper, we review the occurrence mechanism, influencing factors and basic preventive measures of nausea and vomiting after total hip or knee arthroplasty.]]> 2022/7/30 18:40:22 HUANG Xiao, YIN Dong 153true ［Abstract］　As bone tissue substitutes, biomaterials provide a new idea for the treatment of bone defects or fracture nonunion. However,conventional nanomaterials have the disadvantages of damaging cell adhesion and strong cytotoxicity. Thus, the preparation of biomaterials with high efficiency and low toxicity has become a current research hotspot in the field of tissue engineering. Magnetic nanoparticles can provide magnetic stimulation for bone regeneration, and the electromagnetic field is a kind of non-invasive physical therapy to promote bone repair. The magnetic responsive nanomaterials prepared by the combination of the magnetic nanoparticles and the electromagnetic field have been widely studied and applied in the biomedical field. In this paper, the preparation, classification and application of magnetic responsive nanomaterials in bone tissue engineering are reviewed.]]> 2022/7/4 12:13:21 SU Zhi-wen, WU De-guang, LI Dong-tai, et al. 152true ［Abstract］　Type Ⅱ innate lymphoid cells(ILC2) are stimulated to produce T-helper lymphocyte type 2(Th2) cytokines, which promote late phase reaction in allergic rhinitis(AR). Micro ribonucleic acid-155(microRNA-155, miR-155) plays a crucial role in the development of the immune system, the maturation and differentiation of immune cells and the maintenance of immune function. GATA binding protein 3(GATA3) is a transcription factor that can promote the development and maturation of ILC2, and in tumor research, GATA3 is the target gene of miR-155. In this paper, we mainly review the transcription factor GATA3 of ILC2 which is involved in AR in nasal mucosa and miR-155 which can interfere with GATA3 expression.]]> 2022/7/4 12:13:21 HUANG Xue-ying, LI Rong-rong, ZHANG Shao-jie, et al. 151true ［Abstract］　Helicobacter pylori(Hp) infection is one of the major public health threats in the world. Hp infection has a higher infection rate in patients with type 2 diabetes mellitus, and Hp infection is one of the risk factors for macroangiopathy in patients with type 2 diabetes mellitus. This paper reviews the research progress on the relationship between Helicobacter pylori infection and macroangiopathy in type 2 diabetes mellitus.]]> 2022/7/4 12:13:21 CHEN Jun-an, LUO Chang-jun 150true ［Abstract］　Radiation proctitis(RP) refers to rectal injury caused by radiotherapy of malignant tumors in the pelvic and abdominal cavity, and retroperitoneum, which seriously affects the disease prognosis and quality of life of cancer patients. Acute RP is self-limiting and the symptoms can be relieved after stopping radiotherapy. Only a small part of the patients have a severe and prolonged disease or condition. The clinical treatment of RP is mainly symptomatic treatment, so this paper mainly reviews the research progress in the medical therapy of RP.]]> 2022/6/10 17:57:16 LIN Li-li, CAI Hong-yi 149true ［Abstract］　Primary liver cancer is one of the most common malignancies. The early diagnosis of liver cancer is difficult. The overall surgical resection rate of liver cancer is low and the effect of traditional non-surgical treatment is not good. The conversion therapy of liver cancer is to convert unresectable liver cancer into resectable liver cancer through local/systemic treatment and benefit from surgical resection. In recent years, checkpoint inhibitor therapy has made a greater breakthrough in the treatment of advanced liver cancer. Some patients with moderate and advanced liver cancer have regained the opportunity of operation and benefited from the progress of local treatment represented by hepatic artery infusion chemotherapy(HAIC). This paper reviews the research progress in conversion therapy of hepatocellular carcinoma.]]> 2022/6/10 17:57:16 QIN Jian-lun, QIN Wei, MO Shu-tian, et al. 148true ［Abstract］　Anterior cruciate ligament reconstruction with autologous hamstring tendons is a popular surgical procedure for the treatment of anterior cruciate ligament injury of knee joints. It is believed that most tendons can be regenerated in situ after surgery, and can even be used as grafts for secondary reconstruction, and imaging plays an important role in the evaluation of hamstring tendon regeneration. This paper reviews the imaging research progress of regenerated tendons.]]> 2022/6/10 17:57:16 HUANG Xiao-li, ZHENG Hong-yu 147true ［Abstract］　Acute respiratory distress syndrome(ARDS) is a common critical disease in clinic. NLRP3 inflammasome is an important component of innate immune response and participates in the inflammatory process. This paper reviews the role of NLRP3 inflammasome in the occurrence and development of ARDS.]]> 2022/4/29 9:03:57 DONG Jue, JIANG Yu-jie, HUANG Xia, et al. 146true ［Abstract］　Reactive oxygen species(ROS) are by-products of aerobic respiration and metabolism, and are an integral part of sperm development physiology, capacitation and function. Oxidative stress occurs when the concentration of ROS exceeds the buffering capacity of antioxidants, and may have a negative impact on the ultrastructure, morphology and function of sperms. The research status of ROS affecting sperm ultrastructure is reviewed in this paper.]]> 2022/4/29 9:03:57 ZHANG Xi-yan, YAN Yi-xin, QIN Hong-ping, et al. 145true ［Abstract］　The increasing burden of cardiovascular diseases is a major health problem facing the world at present. Targeting gut microbiota is a potentially effective strategy to reduce the incidence and mortality of cardiovascular diseases. In recent years, the rise of probiotic therapy has provided new ideas for the prevention and treatment of cardiovascular diseases. Lactobacillus rhamnosus Gorbach-Goldin(LGG) shows great potential in the prevention and treatment of cardiovascular diseases through various mechanisms, such as anti-inflammation, anti-oxidative stress, regulation of gut microbiota, and protection of intestinal barrier.This paper reviews the research progress of LGG in cardiovascular diseases in recent years.]]> 2022/4/29 9:03:57 WEI Jin-tao, LI Ze-hua, OU Cai-wen 144true ［Abstract］　Vascular endothelial growth factor receptor 1(VEGFR1) is a transmembrane transport receptor, which is mainly related to the secretion of vascular endothelial growth factor(VEGF) family cytokines, and plays an important role in the formation of blood vessels, vascular endothelial cell migration and other basic life activities. In case of cardiac ischemia/reperfusion injury, VEGFR1 can alleviate the injury by regulating oxidative stress, inhibiting cardiomyocyte apoptosis and promoting vascular regeneration. This paper expounds the protective effect of VEGFR1 on cardiac ischemia/reperfusion injury, in order to look forward to a more reasonable clinical application of VEGFR1 as a target in patients with myocardial ischemia in the future and achieve better therapeutic effect.]]> 2022/3/31 9:14:30 HUANG Lu-ying, LI Cheng-yu, YANG Hui 143true ［Abstract］　Ankylosing spondylitis(AS) is a chronic inflammatory rheumatic disease mainly involving the axial bone. AS can cause progressive osteogenic changes of spinal ligaments and eventually leads to rigid kyphosis. Rigid kyphosis often leads to thoracolumbar kyphosis and cervicothoracic kyphosis, and thoracolumbar kyphosis is more common. Surgical osteotomy is the main treatment for thoracolumbar kyphosis of the spine caused by AS. This paper reviews the advances in surgical treatment of thoracolumbar kyphosis in ankylosing spondylitis.]]> 2022/3/31 9:14:30 WU You-cai,YU Cheng-qiang, QIN Yong-ting, et al. 142true ［Abstract］　The staging of tumors is of great significance in guiding treatment and predicting prognosis. In 2018, the International Federation of Gynecology and Obstetrics(FIGO) released new staging criteria for cervical cancer, which included pelvic and para-aortic lymph node metastasis in the staging of cervical cancer for the first time and classified it as stage ⅢC separately. In this paper, we review the related issues of cervical cancer with FIGO stage ⅢC and the related studies on clinical practice at home and abroad.]]> 2022/3/31 9:14:30 CHEN Bo, ZHANG Lu, WANG Qing-long, et al. 141true ［Abstract］　Transient receptor potential vanilloid 1(TRPV1) has attracted much attention as a nociceptor closely related to pain since its first successful cloning, and its molecular structure, physiological function, distribution characteristics, activation and inhibition have been widely studied. TRPV1 receptor is also closely related to pain in terms of its involvement in biological processes such as inflammation and lipid oxidation. A variety of endogenous and exogenous sensitizers or inhibitors can modulate the sensitivity of TRPV1 channel, thus mediating pain signal transmission. TRPV1 may also lead to the ablation of nociceptors through intracellular calcium overload and other mechanisms, which may be a potential effective approach in the treatment of pain. The aim of this paper is to review the research progress on the related mechanisms and the applications of TRPV1 receptor in mediating pain.]]> 2022/3/8 0:00:00 CHENG Xu-tao, HUA Zhen 140true ［Abstract］　FOXA, also known as forkbox transcription factor A, is originally found and extracted from rat hepatocytes and divided into FOXA1, FOXA2 and FOXA3. It plays an important role in embryonic development, metabolism, differentiation, growth and so on. In recent years, studies have shown that FOXA plays an important regulatory role in tumor metabolism, proliferation, extension and metastasis, especially in the process of epithelial-mesenchymal transition(EMT). This paper reviews the research progress on the role of FOXA in malignant tumors of the digestive system.]]> 2022/3/8 10:33:08 HUANG Yang-yuan, WANG Li-yan, CHEN Cai-huang, et al. 139true ［Abstract］　Total knee arthroplasty(TKA) is an effective method for the treatment of knee arthritis.However, the patients often have problems such as joint pain, swelling, activity limitations, and decreased muscle strength after TKA.Rehabilitation therapy plays a good role in improving the complications of the patients after TKA and promoting the recovery of their limb function. This paper reviews the research progress in rehabilitation therapy of TKA.]]> 2022/3/8 10:33:08 LI Xiu-fang, ZHOU De-zhi, YIN Meng-xing, et al. 138true ［Abstract］　Endometriosis(EMS) is a common hormone-dependent disease in gynecology, which often occurs in women of childbearing age. The clinical manifestations of EMS are mainly dysmenorrhea and infertility, and the clinical reports of EMS complicated with early recurrent spontaneous abortion(RSA) are less. The pathogenesis of EMS is still unknown. In recent years, relevant studies have shown that early RSA in patients with EMS is related to ovarian function impairment caused by ectopic endometrial implantation, immunomodulatory disorders, abnormal pelvic anatomical structure, embryo implantation site and development abnormalities caused by pelvic inflammatory reaction. In addition, the elevated prostaglandin levels, prothrombotic state, endocrine disorders and psychological factors in patients with EMS are also important causes for early RSA. In this paper, the research progress of EMS complicated with early RSA is reviewed.]]> 2022/3/8 10:33:08 JIANG Zhi-feng, ZHAO Ren-feng 137true ［Abstract］　Polyetheretherketone(PEEK), a three-dimensional(3D) printing material, is a polymer with many potential applications in the medical field. With the gradual rise of 3D printing technology, PEEK can not only be printed out for personalized implants according to the patients′ conditions and needs, but also has the necessary properties as implants. These two advantages indicate that PEEK is expected to replace the traditional repair materials in the field of auricle repair and reconstruction. This paper reviews the excellent properties of 3D printing material PEEK as implants, and its application prospect in the field of auricle reconstruction.]]> 2022/1/29 11:54:58 WU Di, ZHONG Zi-ling, HAN Xing, et al. 136true ［Abstract］　Type 2 diabetes mellitus(T2DM) and Alzheimer′s disease(AD) are both age-related aging diseases, and there are many common risk factors in the two diseases. The gut microbiota participates in the regulation of insulin physiological functions through a variety of metabolites, and plays a vital role in the occurrence and development of insulin resistance(IR). This paper reviews the internal relationship between gut microbiota metabolites and the pathogenesis of T2DM and AD from the perspective of IR.]]> 2022/1/29 11:54:58 WANG Zhong-ying, CHANG Li-na, Xiang Fang 135true ［Abstract］　Postmenopausal osteoporosis(PMOP) is a systemic bone disease with increasing morbidity in postmenopausal women. To explore its pathogenesis and find methods to prevent or even treat postmenopausal osteoporosis aiming at its mechanism is an important problem to be solved urgently in global public health.In recent years, interleukin-1(IL-1) has been found to play an important role in the occurrence and development of PMOP in some studies. This paper summarizes the research progress on the correlation between IL-1 and PMOP, so as to provide theoretical basis for the prevention and treatment of PMOP and the study of relevant molecular mechanisms.]]> 2022/1/29 11:54:58 FENG Yu, YAO Na, YUAN Bo-lin, et al. 134true ［Abstract］　Coronary atherosclerotic heart disease is the most common type of organ lesions caused by atherosclerosis, among which myocardial infarction caused by myocardial ischemia, hypoxia or necrosis due to coronary artery stenosis or occlusion poses a serious threat to human health. In recent years, studies show that mesenchymal stem cells(MSCs) transplantation has achieved a certain effect in the treatment of myocardial infarction, but there are still some problems and controversies. This paper reviews the biological characteristics, mechanism of action, problems and prospects of MSCs.]]> 2022/12/30 11:06:44 LIU Shu-heng, LIU Mei-lan 133true ［Abstract］　Gestational diabetes mellitus(GDM) is one of the common complications of pregnancy, which manifests as abnormal glucose metabolism during pregnancy and causes profound effects on pregnant women and their fetuses. Physiological changes in the number and type of intestinal flora occur during pregnancy, and numerous studies have showed that changes in the diversity and abundance of intestinal flora are potential contributing factors to the development of GDM. In this paper, we review the literature on the changes in intestinal flora of women with GDM.]]> 2022/12/30 0:00:00 CAO Yu-zhi, WANG Qian, MENG Yu-jun, et al. 132true ［Abstract］　As an emerging detection technology, liquid biopsy is mainly used to take samples of patients′ blood, urine, saliva and other body fluids by a non-invasive or minimally invasive way to detect cancer markers in them for diagnosis, prognosis assessment and follow-up.Liquid biopsy technique has important clinical significance for the early diagnosis, individualized treatment and improvement of prognosis of breast cancer. This paper introduces the research progress of liquid biopsy in breast cancer from the aspects of circulating tumor cells(CTCs), circulating tumor deoxyribonucleic acid(ctDNA) and micro ribonucleic acid(microRNA, miRNA).]]> 2022/12/30 11:06:44 SHEN Jia-yue, TANG Xiao-qi, ZHOU Tao-sheng, et al. 131true ［Abstract］　Psoriasis is a common, chronic, recurrent, inflammatory disease mediated by immune factors. At present, the etiology and pathogenesis of psoriasis are not clear. With the advancement of science and technology, studies have found that micro ribonucleic acid(microRNA, miRNA) plays an important role in the development and regulation of the immune system and the pathogenesis of psoriasis. This paper reviews the research results of miRNA involved in the pathogenesis of psoriasis and the research progress of the therapeutic effects of miRNA on psoriasis.]]> 2022/11/30 11:57:24 XIE Zhi, LI li-li 130true ［Abstract］　Non-suicidal self-injury(NSSI) is a kind of behavior by which one self-injury person deliberately hurts oneself without the purpose of ending his or her life and is not accepted by the society. The incidence of NSSI is high in adolescents, which is closely related to depression and other mental and psychological disorders. At present, the pathogenesis of NSSI is still unclear. Previous studies indicated that the adolescents with NSSI had abnormal brain structure and brain function, and multimodal magnetic resonance imaging(MRI)could provide abundant information for NSSI behavior, which had important value on studying the pathogenesis of NSSI. This paper reviews and summarizes the brain function and imaging studies of multimodal MRI in NSSI behavior.]]> 2022/11/30 11:57:24 YOU Xin-rui, CAO Rui-xiang, BAI Yan, et al. 129true ［Abstract］　Kidney is one of the target organs of obesity. The pathogenesis of obesity-related glomerulopathy(ORG) is complex and has not yet been fully understood so far. At present, the main treatment methods of ORG are weight loss and renin-angiotensin-aldosterone system(RAAS) inhibitors to reduce proteinuria and delay progression to end-stage renal disease in the patients. This paper reviews the research progress of ORG.]]> 2022/11/2 11:21:28 WANG Cong-xiu, GUAN Bao-zhang 128true ［Abstract］　The bodies of diabetic patients are in internal environment of hyperglycemia for a long time, and when their limb ischemia reperfusion(IR) occurs, the tissues and organs of the diabetic patients are more vulnerable and the damages of their tissues and organs are more serious than those of the non-diabetic patients. This paper reviews the myocardial injury caused by limb IR in patients with diabetes mellitus and its prevention and treatment.]]> 2022/11/2 11:21:28 XUE Yang, XU Zi-qing, ZHANG Jie, et al. 127true ［Abstract］　At present, lung cancer is a malignant tumor with relatively high morbidity and mortality in the world. People pay more and more attention to the early screening of lung cancer. Multiple pulmonary nodules(MPNs) are closely related to multiple primary lung cancer(MPLC). MPNs are usually found in low-dose computed tomography(LDCT) screening for lung cancer, and the detection rate of MPNs in the population increases year by year. Currently, the main treatment methods for MPNs are surgical resection and other non-operative treatment methods which include radiotherapy, local ablation, molecular targeted therapy, immunotherapy and chemotherapy. This paper reviews the research progress in the non-operative treatments of MPNs in recent years.]]> 2023/10/12 10:25:14 QI Tao, LI Lun, CHU Heng, et al. 126true ［Abstract］　Artificial intelligence(AI) has shown more and more powerful influence and application prospects in orthopaedics, and spinal orthopaedic surgery is the end-stage treatment of spinal deformities. Spinal orthopedic surgery is highly invasive, with high risk and many complications. AI can choose the therapeutic regimens according to the patients′ conditions to reduce surgical complications and improve surgical outcomes, and can also analyze risk factors associated with specific surgical patients to predict complications and outcomes, and design smarter implants. AI-assisted spinal orthopedic surgery can achieve satisfactory surgical results. This paper reviews the application of AI in spinal orthopedic surgery and summarizes its research progress.]]> 2023/10/12 10:25:14 LI Cheng, XIAO Nian-su, HU Wei 125true ［Abstract］　Myofascitis is an aseptic inflammation of the skeletal muscle system, often characterized by myofascial trigger points, painful tubercles and tense muscle bands in clinic. The common methods of treating myofascitis in modern medicine include oral or topical use of non-steroidal anti-inflammatory drugs, physical therapy and so on, but the symptoms of myofascitis are prone to recurrence, affecting the quality of life and work efficiency of the patients. In recent years, Traditional Chinese Medicine has been used to treat myofascitis with varying therapeutic effects. This paper reviews the research progress of Traditional Chinese Medicine external treatment in myofascitis.]]> 2023/10/12 10:25:14 WANG Cheng, LIAN Zhan-xiong, WEI Suo-su, et al. 124true ［Abstract］　Colorectal cancer(CRC), as a malignant tumor of the digestive system, is difficult to diagnose clinically by symptoms and signs alone because of its insidious onset, and its symptoms and signs are usually in the middle and late stages when diagnosed. The prognoses of the patients with CRC are also significantly different due to different stages. Early screening and diagnosis of CRC can improve the survival of the patients and reduce their mortality. This paper reviews the research progress in the diagnosis of CRC through the detection of stool markers, blood markers and liquid biopsy.]]> 2023/8/31 17:39:32 ZHAO Shi-yu, BAO Guo-lin, FAN Wei-hua, et al. 123true ［Abstract］　In recent years, the incidence of refractory heart failure(RHF) has increased significantly, and RHF patients have serious clinical symptoms, poorer quality of life and poor prognosis. Despite the continuous enrichment of modern medical treatment methods, the treatment of RHF has always been a challenge. In order to better improve the prognosis of RHF patients, this paper reviews the current studies on drug therapy for RHF.]]> 2023/8/31 17:39:32 CHENG Ke, MA Li, MAO Qing-ju 122true ［Abstract］　Methotrexate(MTX) is a dihydrofolate reductase inhibitor, and high-dose MTX shock therapy is commonly used in clinical preventive treatment of extramedullary leukemia. In clinical practice, high-dose MTX is often combined with other drugs, such as antibacterial drugs, proton pump inhibitors and non-steroidal anti-inflammatory drugs, which may lead to pharmacokinetic changes in MTX and affect the safety of administration of MTX. In recent years, a certain correlation between the delayed elimination of MTX and the co-administration of MTX has been reported in several cases. In this paper, the effects of combined drugs on the safety of high-dose MTX in treatment of acute lymphoblastic leukemia in children are reviewed.]]> 2023/8/31 17:39:32 SUN Hui-jing, WEI Si-rou, DAI Yan, et al. 121true ［Abstract］　Thin endometrium refers to the thickness of the endometrium below the minimum threshold for obtaining pregnancy, and is an important indicator for evaluating endometrial receptivity. The diagnostic criteria of thin endometrium are not yet unified, and its impact on pregnancy outcomes is not yet clear. This paper reviews the new progress in the treatment of thin endometrium in assisted reproductive technology.]]> 2023/8/4 12:14:58 TIAN Jing, LING Xiu-feng 120true ［Abstract］　Osteosarcoma(OS) is a kind of primary malignant bone tumor that is prone to occur in children and adolescents. Its main traditional treatment is multi-drug chemotherapy. Due to the problem of drug resistance to chemotherapy drugs, it is particularly urgent to explore new therapeutic targets for OS and carry out relevant researches on drug resistance to OS chemotherapy. Ferroptosis, an iron-dependent, non-apoptotic new type of programmed cell death, is characterized by the accumulation of lipid reactive oxygen species. At present, relevant studies have confirmed that ferroptosis plays important roles in the treatment, prognosis and reduction of drug resistance of OS. The research progress of ferroptosis in OS is reviewed in this paper to provide theoretical basis for the prevention and treatment of OS.]]> 2023/8/4 12:14:58 LI Ming, CHEN Long-ju 119true ［Abstract］　The application of robot operating system in the treatment of rectal cancer is gradually being developed both domestically and internationally, but the specimens still need to be extracted through an auxiliary incision. With the rise of natural orifice specimen extraction surgery(NOSES), the combination of robot operating system and NOSES has achieved good clinical results in the field of rectal cancer surgery. This paper reviews the application status of robotic NOSES in the treatment of rectal cancer.]]> 2023/8/4 12:14:58 DONG Chen-cheng, ZHANG Qiu-huan, ZHU Zhou 118true ［Abstract］　Inflammation is closely associated with cardiovascular diseases. Systemic immune-inflammatory index(SII) is a novel inflammatory marker that integrates neutrophils, lymphocytes and platelets, and can reflect the equilibrium state of systemic inflammation and local immunity more comprehensively. Recent studies have found that SII is closely related to the occurrence, development and prognosis of cardiovascular diseases. This paper reviews the research progress in correlation between SII and cardiovascular diseases.]]> 2023/7/3 10:09:37 LIU Ting, WU Keng 117true ［Abstract］　Acute kidney injury(AKI) is common in advanced liver cirrhosis, mainly including prerenal azotemia, hepatorenal syndrome and acute tubular necrosis. The evaluation of renal function and the differentiation between renal function damage and structural damage are the key points of treatment. The change of serum creatinine level is still the gold standard for the diagnosis of AKI in cirrhosis. However, its role in evaluating the renal function is limited. The novel biomarkers are expected to provide effective diagnosis, differential diagnosis and prognosis evaluation for liver cirrhosis patients with AKI. This paper reviews the recent studies on renal biomarkers of AKI in cirrhosis from the perspectives of diagnosis, etiological identification of AKI and clinical prognosis prediction.]]> 2023/7/3 10:09:37 HUANG Xue-lian, ZHANG Guo 116true ［Abstract］　The incidence and mortality of acute myocardial infarction(AMI) are increasing year by year. The application of revascularization can effectively relieve the symptoms of AMI patients, but the cardiac function of some patients is not improved after percutaneous coronary intervention. Evaluation of viable myocardium is particularly important for the selection of treatment strategies, evaluation of efficacy and prognosis of patients with AMI. Noninvasive imaging is a reliable method to evaluate viable myocardium. This paper reviews the characteristics of noninvasive imaging methods for evaluating viable myocardium and their correlations.]]> 2023/7/3 0:00:00 ZHONG Chang-li, LI Rong-shan 115true ［Abstract］　Parkinson′s disease(PD) is one of the most common neurodegenerative diseases, and its incidence rate is on the rise. The clinical manifestations of PD include four classic motor symptoms and non-motor symptoms. Non-motor symptoms of PD can accompany or precede motor symptoms, and seriously affect the quality of life of the patients. Therefore, the effective assessment of non-motor symptoms of PD is helpful to early identification and severity assessment of non-motor symptoms of the patients, and has important significance to improve the quality of life of the patients. The scales are the main means to assess the non-motor symptoms of PD patients. This paper reviews the non-motor symptom assessment scales commonly used in the current clinical practice.]]> 2023/5/31 0:00:00 LIN Zhao, ZHAO Hong, LU Zheng-yu 114true ［Abstract］　Breakpoint cluster region-Abelson(BCR-ABL) negative myeloproliferative neoplasms(MPNs) are a group of chronic blood cancer, characterized by clonal proliferation of hematopoietic stem progenitor cells. The mutation of JAK2V617F is common in MPNs and is one of the major diagnostic criteria for MPNs. JAK2V617F affects the phenotypic heterogeneity in MPNs through mutation frequency. In addition, signaling pathway, epigenetic modifications, immune abnormality, lifestyle and other factors also play roles in phenotypic heterogeneity. In this paper, we review the advances in the effect of JAK2V617F on MPNs phenotype.]]> 2023/5/31 10:09:27 XIANG Dan-hong, HUANG Jian 113true ［Abstract］　Normal crown-root ratio is an important indicator to determine the stability of teeth in the alveolar bone, whether they have good oral function and the long-term stability after various treatments in clinical orthodontic treatment. Understanding the definition, measurement methods, measurement tools, clinical application and influencing factors of the crown-root ratio in clinical practice will help orthodontists to achieve safe and efficient tooth movement and obtain stable correction effect in the correction of dental and jaw deformities.In this paper, the research progress on the application and influencing factors of crown-root ratio in orthodontic treatment is reviewed.]]> 2023/5/31 10:09:27 LUO Jia-qin, FANG Zhi-xin 112true ［Abstract］　Due to complex pathophysiological changes, the patients with traumatic brain injury(TBI) are often complicated with pulmonary infection, and the patients with pulmonary infection have poor prognosis, high mortality, and it is difficult to diagnose and treat them. With the development of endoscopic technology, fiberbronchoscopy has been widely used in the diagnosis and treatment of severe pulmonary infection, as well as in TBI patients complicated with pulmonary infection. This paper reviews the advances in bronchoscopic alveolar lavage in diagnosis and treatment of pulmonary infection in patients with traumatic brain injury.]]> 2023/4/30 11:53:10 TANG Zheng-neng, WANG Dong-kun, RUAN Chi-yi, et al. 111true ［Abstract］　Nucleoporin 210(NUP210) is a transmembrane nucleoporin glycoprotein involving in constituting the nuclear pore complex. NUP210 is traditionally considered to be involved only in the assembly of nuclear pore complexes and the breakdown of the nuclear membranes. However, recent studies have found that NUP210 is associated with some other biological functions, and its expression is up-regulated in a variety of malignant tumors, which is closely related to the occurrence and development of malignant tumors.This paper reviews the research progress in the relationship between NUP210 and malignant tumors in recent years.]]> 2023/4/30 11:53:10 WU Wei-quan, YE Shi-cai 110true ［Abstract］　MicroRNAs(miRNAs) are a group of small non-coding RNAs, which play the key roles in the biological process of malignant tumors. MiR-4516, one of the main members of miRNAs, is abnormally expressed in a variety of tumors and is closely related to tumor invasion, metastasis and prognosis, and is sensitive to chemical drugs, which has important clinical research value. This paper reviews the research progress of miR-4516 in digestive system neoplasm, glioblastoma, breast cancer, retinoblastoma and thyroid cancer.]]> 2023/4/30 11:53:10 YIN Wu, ZHONG Xiao-gang 109true ［Abstract］　Pulmonary fibrosis is an interstitial lung disease in which excessive deposition of extracellular matrix leads to the destruction of lung structure and scar formation.M2 macrophages are a kind of innate immune cells, which can regulate tissue repair by secreting a variety of pro-fibrotic mediators and play an important role in the pathogenesis of pulmonary fibrosis.This paper reviews the research progress in the effect of M2 macrophages on the pathogenesis of pulmonary fibrosis.]]> 2023/3/30 12:08:59 PI Ding-nan, MO Bi-wen 108true ［Abstract］　Neutrophil extracellular traps(NETs) are a fibrous structure released by neutrophils. The formation process is called NETosis. Recent studies have found that NETs can promote the proliferation, metastasis and recurrence of colorectal cancer. They are closely related to the prognosis of colorectal cancer. In this paper, the relationship between NETs and colorectal cancer is systematically reviewed to further understand the mechanism and clinical value of NETs in colorectal cancer.]]> 2023/3/30 12:08:59 DANG Chun-ping, YUE Hong-yun, ZHANG Bai-hong 107true ［Abstract］　Thalassemia is the most common autosomal recessive inheritance disease in southern parts of China. The pathogenesis of thalassemia is the genetic variation leading to an imbalance in the synthesis ratio of hemoglobin α chain and non-α chain, and the clinical manifestations of thalassemia are abnormalities such as chronic hemolytic anemia and iron overload. The current treatment methods of thalassemia include blood transfusion combined with iron removal therapy, drug therapy, hematopoietic stem cell transplantation, gene therapy and hepcidin-related therapy. The progress in clinical treatment of thalassemia is reviewed in this paper.]]> 2023/3/30 12:08:59 LONG Xi-gui, LI Hong-mian, QIN Ting, et al. 106true ［Abstract］　Affective disorders are a kind of mental disorders with high prevalence, and very complicated pathogenesis. It is of great significance to find out the related pathogenesis of affective disorders for the basic research and clinical treatment of affective disorders. Adenosine receptor plays an important role in affective disorders. This paper reviews the research progress on the mechanisms of adenosine receptor in affective disorders including depression and anxiety.]]> 2023/2/28 12:21:57 FENG Dan, ZHANG Biao, TANG Ming-zhi, et al. 105true ［Abstract］　Bruton′s tyrosine kinase(BTK) inhibitors can inhibit the growth of B cell-related malignancies by targeting BTK in the B cell receptor pathway. However, during the use of BTK inhibitors, some patients develop drug-related atrial fibrillation(AF). AF is one of the most common types of arrhythmia, and it is very important to study the mechanisms of its occurrence and development in the treatment of heart-related diseases. This paper reviews the progress in mechanisms of BTK inhibitor-induced AF.]]> 2023/2/28 12:21:57 GAO Shi-hao, ZHOU Tao 104true ［Abstract］　Ovarian hyperstimulation syndrome(OHSS) is one of the most serious iatrogenic complications in assisted reproductive technology. In the process of controlled ovarian stimulation, some patients develop OHSS, which affects the clinical outcome of assisted reproductive technology treatment, increases the psychological and economic burden of the patients, and endangers the life safety in some severe cases. Therefore, analysis and exploration of the studies on the molecular mechanisms related to OHSS have great significance for the clinical prevention and treatment. This paper reviews recent advances in molecular mechanisms related to the occurrence of OHSS.]]> 2023/2/28 12:21:57 WANG Tian, MO Shao-kang, WANG Ling 103true ［Abstract］　The elevated level of lipoprotein a［Lp(a)］ is an independent risk factor for atherosclerotic cardiovascular diseases(ASCVD), such as coronary artery disease(CAD), stroke, peripheral arterial disease and calcific aortic valve stenosis(CAVS). Studies have confirmed that the high levels of Lp(a) increase the risk of ASCVD even when the levels of low-density lipoprotein cholesterol(LDL-C) are kept within the ideal range. This paper reviews Lp(a) and its pathogenic mechanism, the relationship between Lp(a) level and ASCVD, and the treatment of high Lp(a) level in the blood.]]> 2023/2/10 17:50:33 LOU Qi, WANG Hong, LIU Guang-zhong, et al. 102true ［Abstract］　The most effective method to reduce multiple pregnancies in in vitro fertilization-embryo transfer(IVF-ET) cycles is selective single embryo transfer, and assessing the developmental potential of embryos is one of the key steps. Currently, static assessment systems are mostly used to assess the developmental potential of embryos, which are based on the morphology of the embryos and have certain subjectivity and limitations. With the widespread use of time-lapse imaging monitoring technology(time-lapse), a comprehensive assessment can be performed by morphokinetic parameters and embryo cleavage patterns, which not only provides more valuable parameters for assessing the developmental potential of embryos, but also overcomes the limitations of static assessment.This paper reviews the research progress in the application of time-lapse in IVF-ET.]]> 2023/2/10 17:50:33 WANG Shi-kai, XUE Lin-tao 101true ［Abstract］　The pathogenesis of sepsis is complex. In recent years, studies have confirmed that the activation and mechanism of cyclic guanosine monophosphate-adenosine monophosphate synthetase(cGAS)-stimulator of interferon genes(STING)(cGAS-STING) signaling pathway are of great significance in improving intestinal barrier dysfunction in sepsis. This paper reviews the activation of cGAS-STING signaling pathway, cGAS-STING signaling pathway and septic intestinal inflammatory reaction and the effect of cGAS-STING signaling pathway on intestinal barrier function.]]> 2023/2/10 17:50:33 GAO Wei-wei, WANG Xiao, GUAN Peng, et al. 100true ［Abstract］　Adjuvant endocrine therapy(AET) is an effective treatment strategy for patients with hormone receptor-positive breast cancer and can make the patients obtain significant survival benefits and reduce the risk of recurrence. To determine the most appropriate treatment strategy, AET for early breast cancer should consider a patient′s risk of disease recurrence and menopausal status at the time of diagnosis. The population in perimenopause is the population with high incidence of breast cancer. This paper focuses on the relevant research progress of AET for perimenopausal hormone receptor-positive breast cancer patients.]]> 2023/12/30 8:18:06 LUAN Bi-qing, GE Fei 99true ［Abstract］　The pathophysiological mechanisms of inflammatory diseases involve epigenetic regulation. The post-translational modification of histones is an important component of epigenetics, and the lactylated histones derived from lactic acid is a novel post-translational modification of histones discovered in recent years. Immune cells, including macrophages, play an important role in the repair of tissue damage in inflammatory diseases. Histone lactylation modification, as an epigenetic modification, mediates the expression regulation of immune cell repair genes, glycolytic genes, and programmed cell death, thereby participating in the regulation of tissue damage repair in inflammatory diseases. In this paper, the research progress on the involvement of histone lactylation in regulating tissue damage repair in inflammatory diseases is reviewed.]]> 2023/12/30 0:00:00 TANG Yu-jiao, LIU Ru-xin, BAI Xue, et al. 98true ［Abstract］　Autism children have more difficulties in oral care than healthy children because of their unique physiological and behavioral characteristics. In recent years, many studies on the prevention and treatment of mouth diseases in autism children have been conducted at home and abroad. This paper reviews the prevention and treatment of mouth diseases in autism children.]]> 2023/12/30 8:18:06 HE Yang-yan, YANG Yao-ju, SHI Chun-mei 97true ［Abstract］　The fat mass and obesity-associated protein(FTO) is identified as the first mRNA N6-methyladenosine(m6A) demethylase that regulates body mass index and obesity. FTO regulates the processing, translation and maturation of mRNA of lipid metabolism-related genes by participating in m6A demethylation. In adipose tissues, FTO promotes lipogenesis and inhibits lipolysis by participating in the m6A demethylation process. In the liver, overexpression of FTO can lead to lipid overaccumulation and non-alcoholic fatty liver disease. In other tissues, abnormal expression of FTO affects lipid uptake and metabolic disorders, leading to the occurrence of related metabolic diseases. In this paper, the research progress of m6A demethylase FTO in lipid metabolism is reviewed.]]> 2023/11/30 11:41:23 HUANG Chun-xiao, GUO Xue-ying, XIANG Xin-xin 96true ［Abstract］　Ischemic heart disease(IHD), also known as coronary heart disease, includes a group of diseases caused by coronary artery stenosis or obstruction. It is crucial to treat IHD-induced angiogenesis and vascular reconstruction. In recent years, researches have shown that exosomes can alleviate myocardial ischemia-reperfusion injury, inhibit fibrosis, and promote heart regeneration by promoting angiogenesis, which has a protective effect on IHD. Researches on promoting angiogenesis may provide new options for the treatment of IHD. In this paper,the advances in the treatment methods of angiogenesis induced by IHD is reviewed.]]> 2023/11/30 11:41:23 ZHANG Xue, LIU Mei-lan 95true ［Abstract］　Helicobacter pylori(Hp) infection is associated with various diseases such as chronic gastritis, peptic ulcer, gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer, etc, and all the patients infected with Hp should be given eradication treatment of Hp. As the global antibiotic resistance rate increases, the eradication rate of Hp decreases year by year, and new eradication schemes of Hp need to be excavated. Vonoprazan(VPZ), which is a novel potassium-competitive acid blockers, has strong, stable and long-lasting acid-suppressive effects. Patients with antibiotic resistance can also achieve a good effect when using VPZ. Its treatment as an alternative therapy of proton pump inhibitors has gradually gained serious attention. This paper reviews the mechanism of action, pharmacological properties and the therapeutic research status of VPZ.]]> 2023/11/30 11:41:23 ZENG Lin, NIE Gang 94true ［Abstract］　Cystic neutrophilic granulomatous mastitis(CNGM) is a specific subtype of granulomatous mastitis(GM) with a highly distinctive histological type. CNGM is characterised pathologically by suppurative adipose granuloma surrounded by neutrophils and epithelioid histiocytes forming a central lipid vacuole containing sparse Gram-positive bacteria, and the Gram-positive bacteria can be easily missed or neglected. The research progress in the correlation between Corynebacterium kroppenstedtii and cystic neutrophilic granulomatous mastitis is reviewed in this paper.]]> 2023/11/3 19:25:14 CUI Tian-yue, OUYANG Li-quan, ZHANG Sheng-chu 93true ［Abstract］　Gout is caused by the increase of blood uric acid concentration and the deposition of sodium urate crystals in joints, tendons and surrounding tissues,which leads to intermittent attacks of inflammatory joint disease. Toll-like receptor(TLR) is one of the pattern-recognition receptors(PRRs) in the innate immune system. It has been proved that gouty arthritis is caused by oversaturated monosodium urate(MSU) crystals precipitating in the blood and interacting with macrophages, which leads to the chemotaxis and aggregation of neutrophils, thus activating TLR2/TLR4-nuclear factor(NF)-κB signaling pathway and releasing inflammatory factors such as interleukin(IL)-1β, IL-6 and tumor necrosis factor-α(TNF-α), and proteases, leading to the occurrence and development of gouty arthritis. Taking gout and TLR2/TLR4-NF-κB signaling pathway as the main clue, this paper reviews the correlation between TLR2/TLR4-NF-κB signaling pathway and gout, and the treatment methods targeted by TLR2/TLR4-NF-κB signaling pathway.]]> 2023/11/3 19:25:14 BAI Dong-xue, LI Jing, MA Li-feng 92true ［Abstract］　Peptidyl-prolyl cis/trans isomerase never in mitosis A(NIMA)-interacting 1(PIN1) is abnormally expressed in hepatocellular carcinoma, and plays an important role in the proliferation, invasion, apoptosis and angiogenesis of hepatocellular carcinoma as a tumor catalytic molecule. This paper reviews the molecular structure and function of PIN1，the expression of PIN1 in hepatocellular carcinoma and its role in the occurrence and development of hepatocellular carcinoma.]]> 2023/11/3 19:25:14 MO Zhu-ning, HUANG Li 91true ［Abstract］　Acute myocardial infarction is a sudden reduction or interruption of blood supply to the heart due to a variety of obstructive or non-obstructive coronary causes, resulting in severe and persistent ischemia of the corresponding myocardia, ultimately leading to myocardial cell necrosis. Stem cells are used in the study on myocardial regeneration after myocardial infarction due to their multi-directional differentiation and self-renewal characteristics. In this paper, the research progress on application of stem cells in treatment of acute myocardial infarction is reviewed.]]> 2024/9/29 0:00:00 1, WANG Juan²]]> LYU Yongbo¹, WANG Juan² 90true ［Abstract］　Osteoporosis(OP) is one of the most common comorbidities of rheumatoid arthritis(RA). RA complicated with OP can exacerbate bone destruction, increase the risk of fractures, reduce the patients′ quality of life and increase social burden. The etiology of RA complicated with OP is complex and its pathogenesis is not fully understood. At present, the treatment of RA complicated with OP is a difficult point in clinical work. Understanding the signaling pathways of the disease can provide a new means for developing diagnosis and treatment of the disease. In this paper, the research progress on molecular mechanisms of the signaling pathways in RA complicated with OP is reviewed.]]> 2024/9/29 12:29:45 1, WANG Tingting², JIAN Congcong³, YANG Li¹, WU Jianhong^1,2]]> WANG Huan¹, WANG Tingting², JIAN Congcong³, YANG Li¹, WU Jianhong^1,2 89true ［Abstract］　Triglyceride-glucose(TyG) index is a biomarker of insulin resistance and is closely related to metabolic changes in human body. TyG index can be used as one of the indicators for the evaluation and prediction of some diseases. By monitoring the changes of TyG index, metabolic abnormalities can be detected, which is conducive to early intervention and treatment of diseases. Therefore, the TyG index has important clinical value. In this paper, the research progress on clinical application of TyG index is reviewed.]]> 2024/9/29 12:29:45 HAN Yunbiao, ZHU Lige, YU Lei, XU Libin 88true ［Abstract］　Ribonucleic acid(RNA) splicing dysregulation is one of the important molecular pathological features of tumors, and RNA splicing dysregulation is closely related to abnormal expression of splicing factors. Polypyrimidine tract binding protein 1(PTBP1), a kind of RNA binding protein, is one of the members of the splicing factor heterogeneous nuclear ribonucleoproteins(hnRNPs) family, and is involved in the occurrence and progression of various tumors through regulation of proliferation, migration, invasion, autophagy, apoptosis, immune surveillance and metabolic reprogramming, and is a potential clinical application target for digestive tract tumors. PTBP1, as a key splicing factor, regulates the splicing of target gene precursor messenger RNA(mRNA) and the stability of mRNA, and its novel molecular mechanism for regulating alternative splicing has also been further elucidated in digestive tract tumors. In this paper, the research progress on the role of splicing factor PTBP1 in digestive tract tumors is reviewed.]]> 2024/8/30 10:29:46 ZHOU Yajing, LI Dongbao, ZHOU Jin 87true ［Abstract］　In the children and adolescents in China, the prevalence rate of myopia is relatively high, and it shows a trend of young age and high myopia in myopia patients. The methods for prevention and control of myopia include drug intervention, optical intervention, behavioral intervention and environmental intervention. Orthokeratology(OK) lenses are optical products that can effectively prevent and control myopia. Myopic patients can achieve good naked eye vision by wearing OK lens at night, without the need for wearing frame glasses during the day, and can effectively delay the growth of the axial length. In this paper, the research progress on the factors affecting the effectiveness of night-wearing orthokeratology lens in prevention and control of myopia is reviewed.]]> 2024/8/30 0:00:00 1, DIAO Chunli¹, WU Xixi¹, DING Rui², LIANG Hao³]]> LAI Weixia¹, DIAO Chunli¹, WU Xixi¹, DING Rui², LIANG Hao³ 86true ［Abstract］　Congenital pulmonary airway malformation(CPAM) is a rare congenital cystic lung disease. In recent years, with the development of ultrasonic technology, the detection rate of CPAM has shown an upward trend. CPAM has the risk of repeated pulmonary infection and malignant transformation, so timely surgical treatment of CPAM is very important. Minimally invasive surgery has gradually become the preferred surgical method of CPAM due to its advantages of minimal trauma and rapid recovery. In this paper, the research progress on minimally invasive surgical treatment of CPAM in children is reviewed.]]> 2024/8/30 10:29:47 1, CHEN Junru², BAI Yaming¹, WU Jun¹]]> DAO Ya¹, CHEN Junru², BAI Yaming¹, WU Jun¹ 85true ［Abstract］　Convolutional neural network(CNN) has shown particularly outstanding performance in the field of image recognition. As a representative method of artificial intelligence, CNN has attracted widespread attention in the field of stomatology. CNN has high capabilities in predicting, diagnosing and treating oral diseases, and can help clinicians make treatment plans. In this paper, the research progress on the application of CNN in oral diseases is reviewed.]]> 2024/8/3 0:00:00 LU Yang, ZHOU Mengyuan, XIAO Can 84true ［Abstract］　Examination of the body fluids has become an important direction in the field of tumor research. Exosomes derived from maternal tumor cells contain messenger ribonucleic acid(mRNA), micro ribonucleic acid(miRNA) and other genomic proteins. These genomic proteins have the specificity of maternal tumors, and play an important role in the discovery, diagnosis and treatment of tumors. In this paper, the research progress of exosome detection in diagnosis and treatment of bone tumors is reviewed.]]> 2024/8/3 12:02:39 HU Yongsheng, ZHANG Xiaoxuan, SONG Xinghua 83true ［Abstract］　¹⁸F-fluorodeoxyglucose(¹⁸F-FDG) positron emission tomography/computed tomography(PET/CT) imaging is widely used in clinical practice, and standardized uptake value(SUV) is an important semi-quantitative indicator, which is of great significance for early diagnosis and differential diagnosis of diseases, prediction of early response to tumor treatment, and monitoring of therapeutic efficacy. In this paper, the research progress on measurement techniques, influencing factors and clinical applications of SUV in ¹⁸F-FDG PET/CT imaging is reviewed.]]> 2024/8/3 12:02:39 1,2, ZHOU Qing², SHEN Jun³, XU Bin⁴, ZHU Yuchun²]]> TANG Qingyan^1,2, ZHOU Qing², SHEN Jun³, XU Bin⁴, ZHU Yuchun² 82true ［Abstract］　Oral cancer is one of the most common types of malignant tumors in the head and neck region. Due to its unique location and high degree of malignancy, oral cancer can cause defects in the tissues of the oral and maxillofacial region, leading to loss of functions of language, chewing and swallowing, seriously affecting the patients′ quality of life, and even causing death. Researchers have established animal models of oral cancer similar to human oral cancer to study the etiology, development, infiltration and metastasis mechanisms of oral cancer, providing a basis for the diagnosis and treatment of oral cancer. In this paper, the research progress in establishing animal models of oral cancer is reviewed.]]> 2024/7/2 0:00:00 1,2, WANG Lu¹, XU Fengyi³, HAN Bing²]]> LIU Yan^1,2, WANG Lu¹, XU Fengyi³, HAN Bing² 81true ［Abstract］　Esophageal cancer(EC) is a common malignant tumor of the upper digestive tract, and its morbidity and mortality are increasing worldwide. The early detection rate of EC is low, and the prognosis is poor. Most patients are already in the middle and late stages of the disease when diagnosed. Early diagnosis and reasonable treatment plans are crucial for improving EC patients′ prognosis. Positron emission tomography(PET)/computed tomography(CT) radiomics quantifies and deeply analyzes the feature image data extracted by high-throughput, and then establishes clinical predictive models, which can provide reference for improving treatment strategies and evaluating prognosis of EC patients. In this paper, the research progress on the application of PET/CT radiomics in esophageal cancer is reviewed.]]> 2024/7/2 0:00:00 YU Lingyun, HAN Shuo, LIU Zhixiang 80true ［Abstract］　Vascular endothelium is the key barrier to maintain the balance of internal and external vascular environment. The injury of vascular endothelium can lead to the extravasation of plasma components and accumulation in the surrounding tissues, forming the pathological basis of various diseases. In recent years, the critical role of neutrophil extracellular traps(NETs) in vascular barrier injury has gradually received attention. In this paper, the research progress on the involvement of NETs in vascular endothelial injury in autoimmune diseases is reviewed.]]> 2024/7/2 12:19:14 1, JIANG Fengzhi²]]> ZHANG Wei¹, JIANG Fengzhi² 79true ［Abstract］　Macrophages, as an important component of the body′s immune system, directly affect the host′s ability to clear Mycobacterium tuberculosis(Mtb) through energy metabolism. Hypoxia-inducible factor-1α(HIF-1α) regulates the immune response to Mtb by influencing the energy metabolism pathway in macrophages, and plays an important role in the anti-tuberculosis immunity of macrophages. This paper reviews advances in the regulatory effect of HIF-1α on energy metabolism of macrophages during Mtb infection.]]> 2024/5/31 12:04:37 1, XU Junfa^1,2, ZHENG Biying¹]]> LI Chaowei¹, XU Junfa^1,2, ZHENG Biying¹ 78true ［Abstract］　Rheumatoid arthritis(RA) is an autoimmune disease characterized by synovitis and progressive joint destruction. At present, the pathogenesis of RA is unclear, and pyroptosis, as a newly discovered programmed cell death, has been confirmed to promote the development of RA by releasing pro-inflammatory mediators through intracellular kinase interactions. This paper reviews the research progress of pyroptosis in RA.]]> 2024/5/31 12:04:37 1, ZHOU Dianyou², WU Lijuan³]]> WANG Jiani¹, ZHOU Dianyou², WU Lijuan³ 77true ［Abstract］　Esophageal cancer(EC) is a common malignant tumor with high mortality. The traditional treatment methods of EC, including surgical resection, radiotherapy and chemotherapy, have limited efficacy. With the rapid development of immunotherapy, more and more studies have been exploring the potential of radiotherapy combined with immunotherapy for EC. In this paper, the research progress of radiotherapy combined with immunotherapy for EC is reviewed.]]> 2024/5/31 12:04:37 LIU Qianlin, ZHOU Jundong 76true ［Abstract］　The incidence rates of type 2 diabetes mellitus(T2DM) and heart failure(HF) show escalating trend. The two diseases often coexist, and compared to the patients with a single chronic disease of the two diseases, the patients with comorbidity of the two diseases have poor quality of life and poor prognosis problems. Therefore, early identification and prevention of the patients with a single disease of two diseases are particularly crucial. This paper reviews the research progress in the prevention and treatment of comorbidity of T2DM and HF, in order to help clinicians early identify single disease with high risk of comorbidity and implement effective drug intervention to improve the prognosis of the patients.]]> 2024/4/30 0:00:00 ZHANG Hong, XU Peicheng, MA Li 75true ［Abstract］　Lower limb motor dysfunction is a common sequela in stroke patients, which seriously affects the patients′ quality of life and daily activity ability. In recent years, transcranial direct current stimulation(tDCS), as a new non-invasive neuroregulatory treatment technique, has been applied to improve the lower limb gait balance disorder after stroke, which has received widespread attention. This paper reviews the research progress on tDCS in improving lower limb motor dysfunction after stroke.]]> 2024/4/30 11:24:22 1, ZHANG Lin², LIU Wenying¹]]> DUAN Qian¹, ZHANG Lin², LIU Wenying¹ 74true ［Abstract］　Obstructive sleep apnea(OSA) is a common sleep-related respiratory disorder. Chronic intermittent hypoxia can lead to inflammatory response in the body, activate various inflammatory pathways and aggravate OSA. Inflammatory cytokines are a class of cellular signaling molecules, which transmit information by means of autocrine, paracrine and endocrine. OSA is closely associated with systemic inflammation and inflammatory cytokines. Inflammatory cytokines, including tumor necrosis factor-α, interleukin(IL)-33, IL-17, IL-10, IL-1β, IL-6 and IL-8, have been proven to participate in the pathogenesis of OSA and promote the reactivation of inflammatory pathways. In this paper, the research progress on inflammatory cytokines and the occurrence and development of OSA is reviewed.]]> 2024/4/30 11:24:22 LI Dongyang, GUO Ao, MA Wenbin 73true ［Abstract］　Natural killer(NK) cells are innate lymphocytes with strong cytotoxicity and activity. NK cell-based immunotherapy has achieved significant efficacy in the treatment of hematological tumors, but has achieved lower efficacy in the treatment of solid malignant tumors. In this paper, the function and phenotype of NK cells, and the research progress of NK cells in tumor immunotherapy are reviewed.]]> 2024/4/3 11:46:24 1, WANG Liang², MO Anwei¹, HUANG Yanjing¹]]> XU Wei¹, WANG Liang², MO Anwei¹, HUANG Yanjing¹ 72true ［Abstract］　Positional plagiocephaly(PP) is a disease of abnormal cranial morphology in infants and young children, which can lead to abnormal biological force lines in the pediatric patients. Based on the stress mechanism and long-term hazards of PP in infants and young children, this paper reviews the finite element analysis of cranial mechanics in infants and young children and various mechanical treatment methods, seeking the basis for precise head orthopedics, and broadening the idea of expanding the treatment techniques of head orthopedics in the future.]]> 2024/4/3 11:46:24 YE Xin, YANG Ning, LIU Zhen 71true ［Abstract］　Metabolic dysfunction-associated steatotic liver disease(MASLD) is one of the chronic liver diseases, which causes a serious hazard to human health. However, the pathogenesis mechanisms of MASLD are complex and no specific drugs are available to treat it at present. In recent years, studies have proposed more pathogenesis mechanisms and their corresponding therapeutic schemes. This paper reviews the research progress in the treatment of MASLD.]]> 2024/4/3 11:46:24 1, SONG Huaiyu¹, HUANG Dinggui²]]> LI Fujian¹, SONG Huaiyu¹, HUANG Dinggui² 70true ［Abstract］　The incidence rate of recurrent spontaneous abortion(RSA) in women of childbearing age is about 5%, which seriously affects women′s physical and mental health. The types and quantity of intestinal floras in healthy adults are in a dynamic balance. The disturbance of intestinal floras may affect the occurrence and development of various reproductive endocrine diseases. The composition of maternal intestinal floras during pregnancy undergoes significant changes. This paper reviews the research progress in the effects of intestinal floras and their metabolites on RSA.]]> 2024/3/15 19:12:41 YUAN Xuejiao, ZHANG Ruopeng 69true ［Abstract］　Sepsis-induced cardiomyopathy(SIC) is a reversible myocardial injury caused by sepsis. It is a non-ischemic acute cardiac dysfunction that can significantly increase the mortality rate of sepsis patients, and β₁-receptor blockers have anti-stress, anti-oxidation, immune regulation and cell death inhibition effects, and have potential protective effects on myocardia. This paper reviews the research progress in the effect of β₁-receptor blockers on prevention and treatment of SIC.]]> 2024/3/15 19:12:41 1, YAO Liying¹, WEI Wei², GAO Yan²]]> HU Shenghui¹, YAO Liying¹, WEI Wei², GAO Yan² 68true ［Abstract］　Autism spectrum disorder(ASD) is a type of neurodevelopmental disorder whose prevalence is increasing year by year and there are no drugs to treat the core symptoms of ASD at present. In the absence of the regulation by intrinsic genetic factors, more and more researches have focused on the role of environmental parameters in neurodevelopment. This paper reviews the research progress on the role and application of environmental enrichment in children with ASD.]]> 2024/3/15 19:12:41 1, SANG Gao²]]> YANG Xiaozhen¹, SANG Gao² 67true ［Abstract］　Maxillary skeletal expander(MSE) is one of the orthodontic devices for the treatment of maxillary transverse deficiency(MTD). MSE is an effective treatment method for adult patients who have already passed their developmental peak and have no growth potential.In the treatment of maxillary arch expansion, different treatment schemes are selected according to the development phase of the maxillary midpalatal suture of the patients and the therapeutic goal of maxillary arch expansion. In this paper, the classification, specific operational approach, therapeutic effect and disadvantages of MSE are elaborated, and the research progress of MSE at home and abroad is summarized, so as to provide reference for clinicians to choose treatment schemes reasonably and effectively.]]> 2024/2/29 11:51:55 1, XU Weihua¹, ZHENG Zhijun²]]> WANG Hua¹, XU Weihua¹, ZHENG Zhijun² 66true ［Abstract］　The incidence of colorectal cancer is on the rise. As a precancerous lesion of colorectal cancer, colorectal polyps have received extensive attention. Diabetes mellitus is a risk factor for intestinal polyps, which increases the risk of various tumors, including colorectal cancer, and affect people′s physical health. In this paper, the research progress on the pathogenesis and carcinogenesis of colorectal polyps in patients with type 2 diabetes mellitus is reviewed.]]> 2024/2/29 11:51:55 YANG Teng, XUE Junli 65true ［Abstract］　Osteoarthritis(OA) is one of the most prevalent and highly disabling diseases worldwide, characterized by lesions involving the entire joint, including cartilage degeneration, bone remodeling, osteophyte formation, and synovial inflammation. At present, non-operative treatment of OA can not prevent the progression of OA. Bone marrow mesenchymal stem cells(BMSCs) are pluripotent stem cells derived from bone marrow that have the ability of multidirectional differentiation, self-proliferation, endocrine and paracrine factors to regulate cell and tissue proliferation, apoptosis, and immune response, etc. They play the role in inducing cell proliferation, stimulating angiogenesis, protecting cells from apoptosis and immune regulation. BMSCs have been increasingly used in the treatment of OA. This paper reviews the research progress of BMSCs in treatment of osteoarthritis in recent years.]]> 2024/2/29 11:51:55 LIU Yuhang, LIN Jinying 64true ［Abstract］　Nordihydroguaiaretic acid(NDGA) is a chemical compound extracted from the evergreen shrub fork Larrea divaricata. NDGA is used in the food processing industry due to the discovery of antioxidant properties in it. NDGA has also been proved to have pharmacological effects such as immune regulation, antibacterial action, antivirus activity, anti-tumor activity, anti-angiogenesis, anti-reproduction and anti-fibrosis, suggesting that NDGA has important potential value in the treatment of diseases. However, the role and mechanism of NDGA in the treatment of diseases have not been systematically summarized at present. In this paper, the research progress on pharmacological effects and mechanisms of NDGA is reviewed.]]> 2025/1/6 10:33:01 1,2, YANG Lijuan¹, MO Xiaojin^2,3, ZHANG Ting^2,3, ZHOU Fangye¹]]> GAO Haijun^1,2, YANG Lijuan¹, MO Xiaojin^2,3, ZHANG Ting^2,3, ZHOU Fangye¹ 63true ［Abstract］　Allergic bronchopulmonary aspergillosis(ABPA) is an allergic pulmonary inflammatory disease caused by allergy to Aspergillus antigen(mainly Aspergillus fumigatus). ABPA is characterized by recurrent difficult-to-control wheezing, coughing, expectorating, significantly elevated serum total immunoglobulin E, and pulmonary infiltration and proximal bronchiectasis. The ABPA patients who are not treated promptly may develop progressive respiratory failure and even die.In this paper, the research progress in treatment of ABPA is reviewed.]]> 2025/1/6 0:00:00 1, ZHANG Mingxian¹, CHEN Xiaoxue², ZHANG Huanping²]]> LI Xiaoyao¹, ZHANG Mingxian¹, CHEN Xiaoxue², ZHANG Huanping² 62true ［Abstract］　Chronic non-healing wounds refer to the type of wounds that cannot enter the normal wound healing process or have significantly delayed healing after 3 months of treatment. The healing process of such wounds is jointly inhibited by various factors such as infection, inflammatory response, ischemia and neuropathy. Traditional treatment methods are difficult to achieve ideal therapeutic effects for the patients. Autologous microskin grafting, as a rapidly developing technique in recent years, is widely used for the repair of chronic non-healing wounds due to its advantages of fast wound closure and large expansion scale. At present, there is still a lack of large-scale clinical data to verify the long-term effectiveness and wide applicability of microskin grafting. This paper provides a review of the research progress on the application of microskin grafting in treatment of chronic non-healing wounds.]]> 2025/1/6 10:33:02 1, AN Xiaochun²]]> ZHANG Fuyin¹, AN Xiaochun² 61true ［Abstract］　Diabetic complications include diabetic kidney disease, diabetic retinopathy, diabetic cardio-cerebrovascular disease, diabetic peripheral neuropathy and diabetic foot. The prognosis and outcomes of patients with diabetic complications are generally poor, and diabetic complications pose a serious threat to human health. Inflammation is a potential pathogenesis of diabetic complications. There are more and more studies on the related blood inflammatory markers and diabetic complications. Systemic immune-inflammatory index (SII) is a novel inflammatory marker, which integrates neutrophils, lymphocytes and platelets to more accurately evaluate the inflammatory state of the body. In this paper, the research progress of SII and diabetic complications is reviewed.]]> 2024/12/12 8:08:13 1, NIU Di¹, PANG Xinxin², ZHANG Xiaowei³]]> CHEN Ruifang¹, NIU Di¹, PANG Xinxin², ZHANG Xiaowei³ 60true ［Abstract］　Skin wound healing is an important issue that the medical field has long been concerned about and committed to improving. With the advancement of science and technology, cold plasma provides a new treatment strategy for skin wound healing with its unique advantages. In this paper, the research progress of cold plasma in promoting skin wound healing is reviewed.]]> 2024/12/12 0:00:00 1, DU Juan^1,2, YUAN Zhixin^2,3]]> ZHAO Chaoyue¹, DU Juan^1,2, YUAN Zhixin^2,3 59true ［Abstract］　Childhood interstitial lung diseases(chILD) are a complex and significantly heterogeneous group of diseases that mainly affect the interstitial tissues of children′s lungs, leading to respiratory distress and decrease in lung function, which has a significant impact on the children′s growth and development. Early diagnosis and effective treatment of chILD face many challenges. At present, the diagnostic methods for chILD mainly include imaging examinations and lung tissue biopsies. The treatment strategy for chILD needs to be adjusted according to the specific cause of disease and the individual situation of the patient. Treatment methods include medication, respiratory support and lung transplantation. In this paper, the research progress of chILD is reviewed.]]> 2024/12/12 8:08:13 LI Hongwei, HU Yingjie, CHEN Dehui 58true ［Abstract］　Different diseases can lead to gastrointestinal dysfunction and gastrointestinal symptoms, and then affect the gastric motility and gastric emptying function, seriously affecting the patients′ quality of life. Therefore, assessing the patients′ gastric motility and gastric emptying function is particularly important for guiding clinical treatment and evaluating therapeutic effect and predicting prognosis. Oral gastrointestinal contrast-enhanced ultrasound(OCUS) is the emerging imaging examination method in recent years, and its application in the field of gastric motility and gastric emptying is gradually mature. In this paper, the research progress of OCUS in evaluating the effects of different diseases on gastric motility and gastric emptying function is reviewed.]]> 2024/10/30 20:36:43 1,3, YUE Wensheng^1,2,3,4,5, YANG Hang^1,3, ZHANG Xiyue^1,3]]> LIU Yanzhou^1,3, YUE Wensheng^1,2,3,4,5, YANG Hang^1,3, ZHANG Xiyue^1,3 57true ［Abstract］　Breast cancer is a malignant tumor with a relatively high incidence in women worldwide. In breast cancer patients, human epidermal growth factor receptor 2(HER2)-positive breast cancer cases account for 20% to 30% of the total breast cancer cases, and compared with the other molecular types of breast cancer, HER2-positive breast cancer has a worse prognosis and is more prone to recurrence and metastasis. In recent years, the treatment of HER2-positive breast cancer has attracted much attention, the anti-HER2-targeted drugs can significantly improve the therapeutic effect of HER2-positive breast cancer patients. In this paper, the research progress in targeted therapy for HER2-positive breast cancer is reviewed.]]> 2024/10/30 20:36:43 WU You, DAI Jianguo 56true ［Abstract］　Migraine is a common chronic neurological disorder characterized by moderate to severe headache episodes accompanied by reversible nerve injury and systemic symptoms. Studies have confirmed that multiple mechanisms are involved in the onset of migraine. Vitamin D, as a steroid hormone, plays an important role in various life activities of the human body. Vitamin D deficiency is associated with migraine, and vitamin D has been used as a therapeutic agent in clinical trials for migraine. In this paper, the research progress on the role of vitamin D in the pathogenesis and clinical treatment of migraine is reviewed.]]> 2024/10/30 20:36:43 CHANG Weizun, SONG Zheyuan, ZHOU Luyao, LI Jiasi 55true ［Abstract］　Obstructive sleep apnea syndrome(OSAS) is a prevalent sleep disorder. The traditional diagnostic methods for OSASS have certain limitations. Digital technology has brought innovative breakthroughs to the diagnosis and treatment of OSAS. The progress in application of digital technology in the diagnosis and treatment of OSAS not only enhances the accuracy and convenience of diagnosis, but also optimizes the treatment plans, significantly improving the quality of life of OSAS patients.In this paper, the progress in application of digital technology in the field of diagnosis and treatment of OSAS is reviewed.]]> 2025/9/30 10:04:06 1,2, YANG Yong¹, TIAN Lei¹, SHANG Hongtao¹, BAI Shizhu², YU Bo¹]]> SHI Yulin^1,2, YANG Yong¹, TIAN Lei¹, SHANG Hongtao¹, BAI Shizhu², YU Bo¹ 54true ［Abstract］　Apolipoproteins are important structural and functional components of plasma lipoproteins, which affect lipid transport and metabolism in the human body. The important apolipoproteins related to clinical practice include apolipoprotein A-Ⅰ, apolipoprotein B, apolipoprotein C-Ⅱ, apolipoprotein C-Ⅲ, apolipoprotein E and apolipoprotein(a). In this paper, the research progress in apolipoprotein-related clinical translation and treatment is reviewed.]]> 2025/9/30 10:04:06 1, ZHANG Jie², ZHAO Peng³]]> LIU Mengyu¹, ZHANG Jie², ZHAO Peng³ 53true ［Abstract］　Three-dimensional finite element analysis(3D FEA), as an in vitro research tool, can effectively simulate human mechanical behavior. Its high repeatability and strong comparability make it have important guiding value in clinical practice. The field of stomatology involves a large number of biomechanical issues. With the continuous update of treatment concepts and the continuous progress of biomechanical techniques, the application scopes of finite element analysis in the field of oral biomechanics are extending increasingly. In this paper, the research progress in application of 3D FEA in the field of oral medicine is reviewed.]]> 2025/9/30 10:04:06 1, LIU Shu², GAO Juan², CHU Kejia², ZHENG Zhijun^1,2]]> CHEN Ji¹, LIU Shu², GAO Juan², CHU Kejia², ZHENG Zhijun^1,2 52true ［Abstract］　Glucose and lipid metabolism disorders caused by unhealthy lifestyles and the metabolic diseases they trigger are increasingly becoming a threat to public health. A variety of exercise therapies, including aerobic exercise, resistance training, high-intensity interval training and traditional martial arts exercises, can improve glucose and lipid metabolism disorders to some extent, and reduce the risk of metabolic diseases. In this paper, the research progress in the role of exercise intervention in regulating glucose and lipid metabolism disorders is reviewed.]]> 2025/8/29 0:00:00 1, SONG Zhicong¹, RAN Yuqin¹, SONG Xu², BU Shuai²]]> ZHANG Xihai¹, SONG Zhicong¹, RAN Yuqin¹, SONG Xu², BU Shuai² 51true ［Abstract］　Plant-derived exosome-like nanovesicles(PDNVs) are tiny nanoscale vesicles secreted by plant cells, and are rich in lipids, ribonucleic acids(RNAs), proteins, and various natural plant products. In recent years, PDNVs have attracted much attention due to their good therapeutic effects shown in the treatment of various diseases. Herbal medicine-derived exosome-like nanovesicles(HMDNVs) have great potential in cancer treatment. In this paper, the research progress in potential of PDNVs in cancer treatment is reviewed.]]> 2025/8/29 20:37:53 1, YU Hua²]]> HUANG Hongcai¹, YU Hua² 50true ［Abstract］　Adipose-derived stem cells(ADSCs) are a type of multipotent mesenchymal stem cells isolated from adipose tissues. In recent years, ADSCs have gradually become a research hotspot in the fields of regenerative medicine and immunomodulation. ADSCs not only have the potential for multi-directional differentiation, but also significantly inhibit transplant rejection and induce immune tolerance through various mechanisms, including secretion of multiple immune regulatory factors, signal transmission mediated by exosomes and direct contact between cells. In addition, ADSCs can also reshape the immune microenvironment by regulating the functions of T cells, B cells, dendritic cells and macrophages. With the aid of gene editing and preprocessing techniques, the immunosuppressive efficacy of ADSCs can be further enhanced. In this paper, the research progress in application of ADSCs transplantation in repairing tissue and organ injuries is reviewed.]]> 2025/8/29 0:00:00 1,2, LIANG Anru³, LUO Qinwen², LI Haiye², LI Hongmian^1,2]]> ZUO Yu′er^1,2, LIANG Anru³, LUO Qinwen², LI Haiye², LI Hongmian^1,2 49true ［Abstract］　Osteosarcoma(OS) originates from mesenchymal stem cells and is the most common primary malignant bone tumor, typically occurring in the distal femoral metaphysis, proximal tibia and proximal humerus. OS has a high degree of malignancy and a very poor prognosis, seriously threatening the health and life of children and adolescents. The pathological feature of OS is that tumor cells form an immature bone-like matrix, yet its key pathological mechanism has not been fully elucidated. In recent years, studies have shown that reducing copper levels in tumors through pharmacology may enhance the immunotherapy efficacy of the fight against cancer. Cuprotosis is a novel type of copper-dependent programmed cell death, induced by excessive accumulation of peroxidized lipids. Cuprotosis involves processes such as copper dependence, accumulation of fatty-acylated proteins, and reduction of iron-sulfur cluster proteins. These processes play important regulatory roles in the occurrence and outcome of OS. In this paper, the research progress of cuprotosis in OS is reviewed.]]> 2025/7/31 13:22:43 1, XIONG Xifeng², WANG Peigeng³, LI Xinye¹, MIAO Haixiong^1,2]]> WANG Yi¹, XIONG Xifeng², WANG Peigeng³, LI Xinye¹, MIAO Haixiong^1,2 48true ［Abstract］　Gambling disorder(GD) is a psychological and behavioral disorder characterized by persistent or recurrent gambling behavior, which does harm to individual health and has negative impacts on economy and society. At present, a considerable proportion of GD patients cannot be effectively alleviated through medication or psychological therapy. In recent years, non-invasive transcranial magnetic stimulation technology has made some progress in the treatment of GD. Studies have shown that this technology has certain therapeutic effects in reducing gambling cravings, alleviating negative emotions, and reducing gambling behaviors. However, selecting and setting key parameters such as stimulus target, stimulus mode and stimulus time are still controversial in academic circles. In this paper, the research progress of repetitive transcranial magnetic stimulation in treatment of GD is reviewed.]]> 2025/7/31 13:22:44 1, LI Yuanyuan¹, XU Jiajun¹, LAI Mingfeng¹, FU Peng²]]> SUN Yunyi¹, LI Yuanyuan¹, XU Jiajun¹, LAI Mingfeng¹, FU Peng² 47true ［Abstract］　Interleukin-36(IL-36), as a member of the interleukin-1 superfamily, has pro-inflammatory, pro-fibrotic and immunomodulatory effects. In recent years, studies have found a certain correlation between IL-36 and the occurrence and development of rheumatoid arthritis(RA) and interstitial lung disease(ILD). In this paper, the research progress of the role of IL-36 in RA and ILD is reviewed.]]> 2025/7/4 11:15:38 1, PAN Lili², LIAO Hua²]]> ZHANG Taihua¹, PAN Lili², LIAO Hua² 46true ［Abstract］　The incidence of obstructive sleep apnea(OSA) is high in children and OSA poses a serious threat to them.However, due to the overall lack of social awareness of OSA and the absence of effective screening mechanisms and convenient diagnostic methods, the disease has not yet been fully diagnosed in the target population. In recent years, a certain progress has been made in the diagnosis, treatment and management of the disease, but there are still many controversies. In this paper, the progress in diagnosis and treatment of OSA in children is reviewed.]]> 2025/7/4 0:00:00 YANG Yong, SHI Yulin, LU Jinbiao, SU Zhongping, KANG Yongjie, YUE Juan, YU Bo 45true ［Abstract］　The incidence of hip fractures is relatively high in the elderly population, and operation is the preferred treatment method for hip fractures in the elderly population at present. Elderly patients often have multiple underlying diseases, resulting in a significant increase in surgical risk. Choosing appropriate assessment models is of great significance for predicting the complications and death risks of the patients. In this paper, the research progress in surgical risk assessment systems for hip fractures in the elderly is reviewed.]]> 2025/7/4 11:15:38 LAN Xiaowen, HUANG Wenwen, HUANG Xiao, YIN Dong 44true ［Abstract］　Psoriasis is a chronic inflammatory skin disease, and its pathogenesis is not yet fully clear. At present, researches suggest that immune abnormalities play a significant role in the occurrence and development of psoriasis. Interleukin-1β(IL-1β) is an important member of the interleukin-1 family and has a strong pro-inflammatory effect. In psoriasis lesions, the expression of IL-1β is significantly increased and plays a key role in the pathophysiological process. In addition, the polymorphism of the genes of IL-1β can affect its transcription and expression, and is closely related to psoriasis. In this paper, the research progress in relationship between IL-1β and psoriasis is reviewed.]]> 2025/6/5 10:27:59 LIU Hongjie, LIU Junlin 43true ［Abstract］　Myeloproliferative neoplasms(MPNs) with TP53 gene mutations are at high risk of transforming into leukemia, characterized by repeated copy number variation and DNA damage during the disease progression, and unique erythroid-biased differentiation in the context of JAK2V617F mutations. Studies have shown that the activation of BMP2/SMAD signaling pathway and the change of CEBPA/GATA1 expression ratio in megakaryocyte-erythroid progenitor are its important molecular mechanisms. In addition, complete inactivation of TP53 gene and a certain mutation load are the necessary conditions for leukemia transformation. Chronic inflammation and immune evasion may be the key driving factors for cells with TP53 gene mutations to obtain dominant clones. In this paper, the research progress in transformation of MPNs with TP53 gene mutations into leukemia is reviewed.]]> 2025/6/5 10:28:00 1, HUANG Jian²]]> BAO Xiaojing¹, HUANG Jian² 42true ［Abstract］　Rheumatoid arthritis(RA) and depression often become comorbidity in clinical practice, and RA and depression have some common risk factors and pathological mechanisms. Oxidative stress refers to the imbalance between the excessive accumulations of reactive oxygen species in the body and their related metabolites and the insufficient antioxidant capacity of the body. This imbalance can lead to tissue damage and cause diseases. Oxidative stress plays an important role in the pathological mechanisms of RA and depression. In this paper, the research progress in the mechanism of oxidative stress in the comorbidity of rheumatoid arthritis and depression is reviewed.]]> 2025/6/5 10:28:00 1, YI Menglin¹, WANG Tingting², WU Jianhong²]]> CHENG Fangfang¹, YI Menglin¹, WANG Tingting², WU Jianhong² 41true ［Abstract］　Dental erosion due to gastroesophageal reflux disease refers to irreversible softening and demineralization destruction of dental hard tissues induced by non-bacterial acidification after gastric contents reflux into the oral cavity. The consistency and accuracy of clinical diagnosis of the disease are unsatisfactory. Dental erosion due to gastroesophageal reflux disease is closely related to bruxism, and their synergistic effect can destroy the whole dentition. In consideration of the progressive nature of the disease, early intervention and protection of the integrity of tooth structure are emphasized. In this paper, the research progress in etiology, diagnosis and treatment of dental erosion due to gastroesophageal reflux disease is reviewed.]]> 2025/4/30 9:48:46 1,2, WANG Lei³, SONG Weihua⁴, XU Tingting², CHENG Yanmei^1,2]]> HU Ziling^1,2, WANG Lei³, SONG Weihua⁴, XU Tingting², CHENG Yanmei^1,2 40true ［Abstract］　The pathological phenomenon of disorder of volume status is common in hemodialysis patients and the disorder of volume status is one of the main factors of high morbidity and high mortality of cardiovascular diseases. Therefore, an accurate assessment of body volume status is crucial for the hemodialysis patients. In recent years, volume assessment methods such as ultrasonic evaluation method, bioelectrical impedance analysis and biomarkers have received widespread attention in clinical practice. However, each method has its limitations. In this paper, the research progress of volume assessment methods in hemodialysis patients is reviewed.]]> 2025/4/30 0:00:00 1, GU Yajing¹, LIU Liting², JIANG Yan², SU Chaojiang², LIU Zongyang²]]> XU Ting¹, GU Yajing¹, LIU Liting², JIANG Yan², SU Chaojiang², LIU Zongyang² 39true ［Abstract］　Myopia is a global public health issue, especially in children and adolescents, and the incidence of myopia is increasing year by year. In recent years, low-concentration atropine has attracted wide attention because of its significant effects and minor adverse reactions in the prevention and control of myopia. In this paper, the research progress in the application of low-concentration atropine in treatment of myopia is reviewed.]]> 2025/4/30 9:48:46 LI Jinping, HONG Lu, QIN Decheng 38true ［Abstract］　Hip joint pericapsular nerve group(PENG) block is a newly emerging regional analgesia technique in recent years, which is mainly used for perioperative analgesia in hip surgery. With the in-depth study of this technique, its unique advantages are gradually revealed, and the clinical application scope is also expanded.In this paper, the research progress on clinical application of hip joint PENG block is reviewed.]]> 2025/3/28 8:07:34 QIAN Qing, ZHAO Di 37true ［Abstract］　The incidence of chronic kidney disease(CKD) is increasing year by year and CKD has become a global public health problem. Optimizing the management strategy of CKD and improving the prevention and treatment level of CKD are crucial for controlling the occurrence and development of CKD and reducing the occurrence of end-stage renal failure. In recent years, studies on the correlation between metabolic disorders and CKD have become the focus of attention in the field of prevention and treatment of kidney diseases. Insulin resistance(IR) is one of the key factors in the occurrence and development of CKD, and triglyceride-glucose(TyG) index is easy to obtain in clinical practice, and can be used as an alternative biomarker of IR and a potential biomarker for predicting CKD. Therefore, TyG index has gradually attracted attention. In this paper, the research progress on the correlation between TyG index and CKD is reviewed.]]> 2025/3/28 8:07:34 1, WU Qiuxia², LIANG Meiyuan¹, TANG Sheng², DENG Meiqiu²]]> DU Yingying¹, WU Qiuxia², LIANG Meiyuan¹, TANG Sheng², DENG Meiqiu² 36true ［Abstract］　Diabetic nephropathy(DN) is one of the common clinical complications of diabetes. DN is difficult to cure with a protracted disease course, and needs replacement therapy in the later stage. At present, the pathogenesis of DN is not fully understood, and there is a lack of effective treatment method in clinical practice. In recent years, researches have found that microinflammatory plays an important role in the disease progression of DN. Western Medicine believes that the pathogenesis of microinflammation of DN is related to endoplasmic reticulum stress, imbalance of intestinal flora, abnormal activation of renin-angiotensin system, disorders of glucose and lipid metabolism, etc. Anti-inflammatory treatment has become a new idea and method to treat DN. Traditional Chinese Medicine(TCM) practitioners believe that microinflammation of DN is related to the concepts of “stagnant heat ”, “dampness turbidity ” and “dampness heat” in TCM theory. In terms of treatment, some methods such as medication and TCM external treatment were adopted through the syndrome differentiation of TCM. In this paper, the research progress on etiology, pathogenesis and treatment of microinflammatory state in DN is reviewed.]]> 2025/3/28 8:07:34 PAN Xinyu, GAO Yunyi, WEI Shuwu, CHEN Ruishuang, WEI Junping 35true ［Abstract］　Platelets play an important role in thrombosis, especially in arterial thrombosis. However, antithrombotic drugs have more or less adverse reactions at present. Therefore, it is of great significance to explore and study new candidate drugs for the clinical treatment of thrombosis-related diseases. In this paper, the research progress on mechanisms related to antiplatelet thrombosis in Traditional Chinese Medicine is reviewed.]]> 2025/3/1 12:31:01 1, QIAO Jianlin²]]> GU Wei¹, QIAO Jianlin² 34true ［Abstract］　Patients with refractory gout(RG) often have severe disease condition, and don′t respond well to medication. The patients are prone to recurrent acute attacks, and are more prone to joint destruction and dysfunction, which seriously affect the quality of life of the patients. In recent years, a new understanding of the clinical characteristics and risk factors of RG has been obtained, and new progress has been made in the research of therapeutic drugs. In this paper, the research progress of drug therapy for RG is reviewed.]]> 2025/3/1 0:00:00 1,2, YU Ling³, LI Guo¹, ZHANG Quanbo², QING Yufeng²]]> WANG Peng^1,2, YU Ling³, LI Guo¹, ZHANG Quanbo², QING Yufeng² 33true ［Abstract］　Osteomyelitis is an infectious inflammation of deep tissues caused by bacterial infection. Persistent infection leads to dissolution and necrosis of bone tissues. The treatment of osteomyelitis becomes complicated because of the emergence of drug-resistant strains and the formation of bacterial biofilms. As a new anti-infection method, sonodynamic therapy(SDT) can effectively kill bacteria and destroy the biofilms of the bacteria by activating the reactive oxygen species(ROS) generated by acoustic sensitizer with ultrasound, which has a good effect on infection caused by drug-resistant bacteria.In this paper, the research progress of SDT for osteomyelitis is reviewed.]]> 2025/3/1 12:31:01 YUAN Yugang, LIU Liyang, CUI Cao 32true ［Abstract］　Platelet-rich plasma(PRP) is rich in high concentrations of platelets and a variety of cytokines, and has the properties of anti-inflammatory, promoting cell proliferation and tissue repair. At present, PRP has been widely used in stomatology, orthopedics, plastic surgery, otolaryngology and other fields, with remarkable efficacy and high safety. Autologous PRP is derived from the patient′s own plasma without the risk of immune rejection and disease transmission. In recent years, autologous PRP has been gradually applied to the treatments of respiratory diseases such as bronchial fistula, bronchial hemorrhage, chronic obstructive pulmonary disease, inhalation lung injury and spontaneous pneumothorax. In this paper, the progress in the application of autologous PRP in respiratory diseases is reviewed.]]> 2025/2/7 0:00:00 LI Xiaopeng, HUANG Min, YUAN Shouqin, HE Yayun, HE Renzhong, JIANG Zhan 31true ［Abstract］　Breast cancer is one of the most common malignant tumors in women.The status of axillary lymph nodes is very important for the clinical staging, treatment strategy and prognosis assessment of breast cancer. Although traditional open sentinel lymph node biopsy is significantly effective in evaluating the status of axillary lymph nodes in early breast cancer, it may leave large scars after surgery and the patients have a longer recovery period. With the continuous progress of endoscopic technology, the application of endoscopic-assisted sentinel lymph node biopsy in the treatment of breast cancer is increasing. In this paper, the research progress on the application of endoscopic sentinel lymph node biopsy in breast cancer is reviewed.]]> 2025/2/7 8:31:46 1,2, ZHAO Yingzhu², HUANG Dong², ZOU Quanqing²]]> WEI Wensong^1,2, ZHAO Yingzhu², HUANG Dong², ZOU Quanqing² 30true ［Abstract］　The problem of facial aging is age-related, mainly caused by sagging and volume loss of facial soft tissues, which is a key aspect of facial rejuvenation treatment. The facial rejuvenation treatment is gradually shifting towards a combination of facial lifting surgery and facial fat filling surgery. Facial lifting surgery mainly solves the problems of sagging and loosing facial skin, while facial fat filling surgery can restore the loss of facial volume and improve skin texture. This combined surgery can solve the problem of facial sagging and the problem of increased facial volume under the same course of treatment, which can improve the overall appearance of facial aging and provide targeted treatment for local aging problem. In this paper, the research progress of facial lifting surgery combined with facial fat filling surgery in facial rejuvenation is reviewed.]]> 2025/2/7 8:31:46 1, CHEN Weihua²]]> ZHU Tianyu¹, CHEN Weihua² 29true ［Abstract］　Polymyositis(PM) is a rare heterogeneous autoimmune disorder, characterized by symmetrical proximal muscle weakness as the mainly clinical manifestation, which can affect the quality of life and life expectancy of the patients. The etiology and pathogenesis of PM are complex and highly heterogeneous, involving multiple levels and pathways such as genetic susceptibility, environmental triggering factors and the immune system. In this paper, the research progress in complex immunopathogenesis and multi-target therapy of PM is reviewed.]]> 2025/12/31 13:19:40 1, GAO Mengxun¹, HU Maomao¹, WANG Miaomiao¹, MA Feilan¹, GUO Donggeng^1,2,3]]> MA Jingshu¹, GAO Mengxun¹, HU Maomao¹, WANG Miaomiao¹, MA Feilan¹, GUO Donggeng^1,2,3 28true ［Abstract］　The global burden of diseases in cervical cancer, endometrial cancer and ovarian cancer continues to increase, and the onset age of patients with these diseases shows a trend of getting younger. As an emerging therapeutic strategy, hyperthermic intraperitoneal chemotherapy(HIPEC) has been proven to significantly improve the prognosis of patients with advanced, recurrent or metastatic gynecological malignant tumors by constructing a synergistic thermochemotherapy system, especially in ovarian cancer patients after interval cytoreductive surgery. Given that the regulation of tumor microenvironment is a key mechanism for HIPEC to exert therapeutic effects, in-depth research on the mechanism is expected to provide the patients with more precise personalized treatment regimens. In this paper, the research progress of HIPEC combined with multimodal therapy in regulating the microenvironment of gynecological malignant tumors is reviewed.]]> 2025/12/31 13:19:40 1, YANG Jiang², WEN Shiyu¹, QIN Xiaomin²]]> DUAN Shiqian¹, YANG Jiang², WEN Shiyu¹, QIN Xiaomin² 27true ［Abstract］　Artificial intelligence(AI) has brought new transformations to academic research and scholarly publishing, emerging as a new productive force driving technological progress and societal development. However, the application of AI in medical research and publishing field faces a series of ethical risks, which has attracted widespread attention in the publishing industry. This article provides an overview of the current application status, ethical dilemmas, and governance pathways of AI technology in various aspects of medical research and scholarly publishing, aiming to offer references for medical science and technology journals in addressing ethical issues arising from the application of AI in the field of medical research.]]> 2025/12/31 0:00:00 JIANG Longyan, YU Jun, LYU Wenjuan, WEI Ying, ZHANG Hongman, HUANG Xiaohong 26true ［Abstract］　Cardiac autonomic neuropathy(CAN) in diabetes is a common complication of type 2 diabetes mellitus, which seriously affects the quality of life and life span of the patients. Exercise training, as an economical and effective intervention method, has significant effects on preventing and delaying the progression of CAN, as well as improving cardiac autonomic nervous function(CAF). Exercise training can improve CAF by improving heart rate variability, activating baroreceptor reflex, and strengthening heart rate recovery after exercise. In this paper, the research progress in effects of exercise training on CAF in type 2 diabetes mellitus patients is reviewed.]]> 2025/11/29 0:00:00 1, YOU Qiqi², XU Shaoyong³]]> JIA Yanyan¹, YOU Qiqi², XU Shaoyong³ 25true ［Abstract］　With the widespread application of general anesthesia techniques in pediatric patients, the effects of drugs for general anesthesia on their developing brain function have become one of the issues that people pay high attention to. The prolonged and repeated exposures of drugs for general anesthesia to infants and young children during their infancy and early childhood may lead to long-term cognitive and behavioral function impairments, significantly increasing the risk of developing diseases such as learning disabilities and attention deficit disorders. The neurotoxic mechanisms such as apoptosis, mitochondrial dysfunction and oxidative stress caused by early exposure to drugs for general anesthesia may be significant causes of long-term cognitive and behavioral function impairments in infants and young children. In this paper, the research progress in the effects of drugs for general anesthesia on brain development of infants and young children is reviewed.]]> 2025/11/29 21:17:25 1, SHI Zhaoling², QIN Weifeng¹, SHI Wenpu³, SUN Xude³, ZHANG Xiajing³]]> JIN Hua¹, SHI Zhaoling², QIN Weifeng¹, SHI Wenpu³, SUN Xude³, ZHANG Xiajing³ 24true ［Abstract］　Parkinson′s disease(PD) is a common neurodegenerative disease with insidious onset and atypical early symptoms, posing challenges for early diagnosis and treatment. Eye movement abnormalities, as an important window reflecting the dysfunction of the central nervous system, show a good application prospect in the research of PD. In this paper, the research progress in pathological mechanisms and clinical application value of eye movement abnormalities in PD is reviewed.]]> 2025/11/29 21:17:25 1,2, MO Qi³, CHEN Yangkun^1,2]]> LAI Jiongyao^1,2, MO Qi³, CHEN Yangkun^1,2 23true ［Abstract］　Minimal change disease(MCD) is a glomerular disease characterized by mild glomerular lesions under light microscopy, often lacking immune complex deposition, but characterized by diffuse foot process fusion under electron microscopy. Previous studies have generally believed that this disease is closely related to T lymphocyte dysfunction. However, recent studies have found that the depletion agent of B lymphocytes, rituximab(RTX), can induce remission of MCD, suggesting that B lymphocytes may play an important role in the occurrence and development of MCD. In this paper, the research progress in involvement of B lymphocytes in pathogenesis of MCD is reviewed.]]> 2025/10/31 10:05:07 XING Xueqi, WANG Yan, HE Weichun 22true ［Abstract］　Lung cancer is one of the leading causes of cancer deaths worldwide. Visceral pleural invasion(VPI) refers to the infiltration of tumor cells beyond the elastic fibrous layer of the pleura. VPI has significant effects on the clinical staging and survival prognosis of patients with early-stage lung cancer. Imaging examinations have the advantages of comprehensiveness, non-invasiveness and good repeatability, and have played an important role in the preoperative assessment of the VPI status of lung cancer. In this paper, the progress in imaging studies on VPI in lung cancer is reviewed.]]> 2025/10/31 0:00:00 1, LI Siye², SHEN Jun³, XU Bin⁴, YU Yueyang¹, ZHU Yuchun⁵]]> HUANG Zikang¹, LI Siye², SHEN Jun³, XU Bin⁴, YU Yueyang¹, ZHU Yuchun⁵ 21true ［Abstract］　CO external fixation technique, an innovation based on the development of traditional Chinese orthopedics, demonstrates good clinical efficacy in treatment of limb fractures and aligns with the biomechanical principles of fracture healing. However, the molecular biological mechanisms by which CO external fixation technique promotes fracture healing remain unclear. This paper discusses the molecular biological mechanisms of CO external fixation technique in promoting osteogenic differentiation of bone marrow mesenchymal stem cells and vascularization of endothelial progenitor cells on the basis of traditional Chinese medicine theory and biomechanical principles of CO external fixation technique, and summarizes the signal pathways that may be involved in these molecular biological mechanisms, which will provide new ideas for the scientific treatment of fractures in traditional Chinese medicine and the experimental researches of CO external fixation technique.]]> 2025/10/31 10:05:07 1, LI Xiaomin¹, LI Rui¹, DAI Junze¹, CHENG Yongzhong¹, WANG Chaolu^1,2]]> LIU Fei¹, LI Xiaomin¹, LI Rui¹, DAI Junze¹, CHENG Yongzhong¹, WANG Chaolu^1,2 20true ［Abstract］　The mammary gland is a highly dynamic organ in mammals. Its development mainly occurs from birth to puberty and pregnancy, and it involves processes of regression and regeneration. The culture of organoids has become efficient methods for studying mammary gland development and breast cancer due to their high similarity in structure and function to in vivo tissues. The technology of mammary organoids demonstrates significant application value in characterizing mammary stem cell properties, investigating tumor initiation mechanisms, and developing personalized treatment strategies. This paper systematically reviews the molecular regulatory network and morphogenetic processes of mammary gland development, focusing on the three-dimensional culture microenvironment for constructing mammary organoids, the dynamic regulatory system of mammary stem cells, and the activation conditions of signaling pathways.]]> 2026/7/31 10:41:34 1, Shi Xin^1,2, Zhang Chenglu¹, Zeng Dejun¹, Wu Jiayong³]]> Peng Siqi¹, Shi Xin^1,2, Zhang Chenglu¹, Zeng Dejun¹, Wu Jiayong³ 19true ［Abstract］　Cervical cancer(CC) poses a serious threat to female health. Early and precise diagnosis and treatment are crucial for improving the prognosis. The high heterogeneity of the tumor microenvironment(TME) hinders the development of effective treatment strategies. Single-cell RNA sequencing(scRNA-seq) technology provides a powerful tool for deciphering the cellular heterogeneity of CC. This paper reviews the research achievements of scRNA-seq in the field of CC in recent years, aiming to explore the application potential of this technology in resolving the heterogeneity of TME, elucidating metastatic mechanisms, and guiding the development of therapeutic strategies.]]> 2026/7/31 10:41:34 1, Cheng Yinglong², Liu Li²]]> Zheng Rui¹, Cheng Yinglong², Liu Li² 18true ［Abstract］　Alzheimer′s disease(AD) is the most common type of dementia, and its pathological mechanisms have not been fully elucidated. Dyslipidemia, as a significant contributing factor to various chronic diseases, is also a controllable risk factor for AD. Dyslipidemia may lead to changes in gray and white matter as well as brain network connectivity in AD patients through multiple pathways, including β-amyloid protein and tau protein deposition, induction of neuroinflammatory responses, causing damage to the blood-brain barrier, and interactions with genetic susceptibility, ultimately resulting in cognitive dysfunction. However, the specific mechanisms remain unclear. This paper reviews the research progress of magnetic resonance imaging(MRI) related to AD and brain structure and function from the perspective of the lipid theory.]]> 2026/7/31 10:41:34 1,2, Lei Miao³, Deng Demao³]]> Lu Tao^1,2, Lei Miao³, Deng Demao³ 17true ［Abstract］　Hepatocellular carcinoma(HCC) is one of the malignant tumors with the highest mortality rate worldwide. The incidence rate of HCC in China is relatively high, and the prevention and treatment situation is severe. The existing treatment methods for HCC still have considerable limitations. In recent years, oncolytic viruses(OVs) have demonstrated advantages in treatment of HCC. In this paper, the research progress of OVs in treatment of HCC is reviewed.]]> 2026/6/30 0:00:00 1,2, CAI Ling², WANG Gang², ZHU Shaoliang³, LUO Honglin^1,2]]> YANG Tao^1,2, CAI Ling², WANG Gang², ZHU Shaoliang³, LUO Honglin^1,2 16true ［Abstract］　Cell death plays a crucial role in the pathophysiological processes of diseases, and in-depth analysis on its mechanisms and regulatory networks is of great scientific significance. As a novel form of programmed cell death, ferroptosis is involved in regulating and controlling the pathological processes of various cardiovascular diseases and may become a potential intervention target. In this paper, the advances in molecular mechanisms and clinical researches of ferroptosis in the development and progression of cardiovascular diseases are reviewed.]]> 2026/6/30 0:00:00 1, LU Zhengde², ZHANG Chaoyong¹]]> HU Yaoshi¹, LU Zhengde², ZHANG Chaoyong¹ 15true ［Abstract］　Epstein-Barr virus(EBV) is a type of ubiquitous oncogenic herpes virus and closely associated with various diseases such as infectious mononucleosis, chronic active EBV infection, and EBV-related autoimmune disorders. EBV primarily infects children aged 3 to 5 years. Recent studies reveals that the immunological imbalance of Th17(T helper cells 17)/Treg(regulatory T cells) plays a significant role in the development and progression of EBV-associated diseases. EBV can disrupt the balance of Th17/Treg by regulating host immune responses, leading to immune system disorders and creating favorable conditions for persistent viral infection and progression of related diseases. In this paper, the research progress of the immunological imbalance of Th17/Treg in children with EBV infection-related diseases is reviewed.]]> 2026/6/30 0:00:00 YANG Pengli, PANG Gaofeng 14true ［Abstract］　Diabetic nephropathy(DN) is one of the most significant microvascular complications of diabetes, and renal fibrosis is the core pathological link for its progression to end-stage renal disease. The pathogenesis of diabetic nephropathy-related renal fibrosis is complex, mainly involving oxidative stress, inflammatory response, abnormal expressions of key cytokines and regulations of multiple signaling pathways. The therapeutic strategies of diabetic nephropathy-related renal fibrosis include traditional targeted intervention strategies, emerging therapeutic targets such as vitamin D receptors and NLRP3 inflammasomes, as well as multi-component and multi-target regulation strategies of traditional Chinese medicine. In this paper, the research progress in the pathogenesis and treatment of diabetic nephropathy-related renal fibrosis is reviewed.]]> 2026/5/29 19:40:21 WANG Jing, XIONG Fei 13true ［Abstract］　The lesion of endometriosis is essentially a wound that undergoes repeated tissue injury and repair. Fibrosis is the main pathological feature of endometriosis. Its core mechanisms include the processes of cellular plasticity involving epithelial-mesenchymal transition, fibroblast-myofibroblast transition and macrophage-myofibroblast transition. The excessive deposition of extracellular matrix components produced by myofibroblasts derived from cell-cell transition leads to the formation of permanent scars and the loss of normal tissue structure and function. In this paper, the research progress in the role of cell transition in the development and progression of fibrosis in endometriosis is reviewed.]]> 2026/5/29 19:40:21 1,3, LIANG Yanchun², CAI Heng³, WEN Jinjuan³, JIANG Shaoru^1,3]]> HE Yao′e^1,3, LIANG Yanchun², CAI Heng³, WEN Jinjuan³, JIANG Shaoru^1,3 12true ［Abstract］　The clinical benefits of tumor immunotherapy are significantly limited by the profound spatial heterogeneity of the tumor microenvironment, especially the existence of “immune cold zones”. The breakthrough of spatial transcriptomics(ST) technology has made it possible to empower high-resolution dissection of the spatial topological framework of immune evasion at subcellular and single-cell scales. This paper systematically describes the application of ST in identifying immune-desert and immune-excluded niches, and discusses the core role of tertiary lymphoid structures maturity-related gradients and their spatial distribution in determining the efficiency of effector cell infiltration. On this basis, this paper proposes that the dissection of the tumor immune microenvironment should transition from simple “spatial description” to a “functional spatial intervention” model. By remodeling epigenetics, precisely blocking metabolic pathways, and inducing the generation of high endothelial venules, the immunopermissive microenvironment can be reconstructed, providing a scientific theoretical basis based on spatial biology for overcoming immunotherapy resistance in solid tumors.]]> 2026/5/29 19:40:21 1, CHEN Qicong², WEI Jiazhang³]]> QU Ziquan¹, CHEN Qicong², WEI Jiazhang³ 11true ［Abstract］　Rheumatoid arthritis(RA) is a chronic systemic immune-mediated disease caused by the combined effect of genetic and environmental factors, characterized by the production of autoantibodies, resulting in symmetrical lesions of peripheral joints. The main clinical manifestations of RA include joint swelling, morning stiffness and persistent pain. In recent years, some studies show that the composition of the gut microbiota in RA patients is significantly different from that in healthy people. In this paper, the research progress in the effects of gut microbiota imbalance on RA is reviewed.]]> 2026/4/30 0:00:00 1, LUO Yuhan¹, ZHANG Lang¹, YUAN Jing², ZHA Yan², LIN Xin^1,2]]> SHAO Xingqin¹, LUO Yuhan¹, ZHANG Lang¹, YUAN Jing², ZHA Yan², LIN Xin^1,2 10true ［Abstract］　Unilateral biportal endoscopy(UBE) technique is a rapidly developing minimally invasive spine surgery technique in recent years. Its core feature is to construct two independent channels on the same side of the spine, one for providing a field of vision and the other for operating instruments. Compared with traditional open surgery, UBE technology has the advantages of shorter operation time, less bleeding, faster postoperative recovery and satisfactory surgical outcomes in treatment of lumbar disc herniation(LDH). In recent years, the incidence of LDH has been on the rise and has seriously affected the quality of life of the patients.In this paper, the research progress of UBE technique in treatment of highly migrated LDH is reviewed.]]> 2026/4/30 0:00:00 1, HU Yang²]]> LIU Pengju¹, HU Yang² 9true ［Abstract］　The incidence and mortality rates of lung cancer have been long ranked top among malignant tumors, posing a serious threat to public health and becoming a major public health issue in China. Pyroptosis is a novel type of programmed cell death and has received extensive attention in recent years. Researches have confirmed that gasdermin D(GSDMD), as a key effector molecule of pyroptosis, is closely related to the occurrence and development of tumors. In non-small cell lung cancer(NSCLC), the high expression of GSDMD plays a significant role in the occurrence, development, treatment, drug resistance and prognosis of the disease. In this paper, the research progress in the mechanism of GSDMD-mediated pyroptosis and its clinical translation in non-small cell lung cancer is reviewed.]]> 2026/4/30 11:10:44 YOU Xiu, WANG Lihong 8true ［Abstract］　Patellofemoral osteoarthritis is a common degenerative disease of the knee joints among middle-aged and elderly populations. The main manifestations of patellofemoral osteoarthritis include anterior knee pain and difficulty in going up and down stairs. In recent years, the incidence of the disease has been on the rise year by year, which not only seriously affects the quality of life of the patients but also imposes a significant economic burden on society. At present, there are many treatment methods for patellofemoral osteoarthritis, but individualized treatments are still in the early stages of the research. Biological therapy, as an emerging therapeutic approach, exerts therapeutic effects through promoting cartilage regeneration, regulating immunity, reducing inflammatory responses and secreting bioactive substances, and gradually becomes a research hotspot in the treatment of patellofemoral osteoarthritis. In this paper, the research progress of biological therapy in treatment of patellofemoral osteoarthritis is reviewed.]]> 2026/3/31 0:00:00 1, XU Qi², HUO Lukuan¹, WU Xiaozhe¹, HA Chengzhi²]]> JIA Shuwei¹, XU Qi², HUO Lukuan¹, WU Xiaozhe¹, HA Chengzhi² 7true ［Abstract］　Acute ischemic stroke(AIS) is a severe thrombotic disease with high incidence, disability and mortality rates. Its pathogenesis is complex, and thrombosis and aseptic inflammation are the core pathological processes. Neutrophil extracellular traps(NETs) are fibrous mesh-like structures released by activated neutrophils, which not only participate in host defense against pathogens but also play a crucial role in the pathological processes of thrombotic disease. NETs can initiate and amplify the thrombus-inflammation cascade, induce brain tissue damage, and aggravate the progression and deterioration of AIS. In this paper, the research progress in NETs-mediated AIS is reviewed.]]> 2026/3/31 9:16:42 1, ZHANG Yixin¹, YIN Limin^1,2, PU Kuairong², ZHAO Xiaoli^1,2]]> WANG Yaxin¹, ZHANG Yixin¹, YIN Limin^1,2, PU Kuairong², ZHAO Xiaoli^1,2 6true ［Abstract］　The incidence of type 2 diabetes mellitus(T2DM) is on a continuous upward trend. The pathological mechanisms of T2DM are relatively complex, involving insulin resistance, disorders of glucose and lipid metabolism and intestinal flora imbalance. Marine-derived chitooligosaccharides(COS) and its derivatives have significant multiple biological activities such as anti-inflammation, antioxidation, improving glucose and lipid metabolism, and regulating gut microbiota. The multi-target synergistic mechanisms of COS and its derivatives in anti-diabetes provide theoretical support for the construction of targeted nutritional intervention programs and highlight the clinical translational value in the comprehensive treatment of diabetes. In this paper, the research progress in mechanisms of COS regulating T2DM through multiple targets is reviewed.]]> 2026/2/28 11:50:11 1, WEI Xiaomei¹, XIANG Xinxin²]]> DING Yabin¹, WEI Xiaomei¹, XIANG Xinxin² 5true ［Abstract］　Among intracranial secondary malignant tumors, cystic metastatic brain tumors are relatively uncommon. In view of the large volume and obvious space-occupying effect of cystic metastatic brain tumors, the clinical symptoms of the patients with cystic metastatic brain tumors are relatively serious and their prognoses are relatively poor. At present, there is still a lack of a standard treatment regimen for cystic metastatic brain tumors. Therefore, optimizing treatment regimens to improve the patients′ quality of life, prolong their survival period and improve their long-term prognoses has become an important issue of concern for clinicians. In this paper, the research progress in diagnosis and treatment of cystic metastatic brain tumors is reviewed.]]> 2026/2/28 11:50:11 WANG Zhen, HE Zhanbiao 4true ［Abstract］　Acute respiratory distress syndrome(ARDS) is a life-threatening critical illness. In recent years, the role of nuclear receptor neuron-derived clone 77(Nur77) in pathogenesis of ARDS has gradually attracted attention. Nur77, as a nuclear transcriptional regulatory protein, is widely distributed in various tissues and cells. The expression of Nur77 is influenced by various external stimuli. Nur77 is involved in the pathophysiological processes of ARDS by regulating multiple mechanisms such as metabolic reprogramming, immune homeostasis balance, and inflammatory signal transduction. In this paper, the research progress in the role of Nur77 in pathogenesis of ARDS is reviewed.]]> 2026/1/31 11:24:05 1,2, LIANG Yejin^1,3, JIANG Yujie⁴]]> ZHONG Jinmei^1,2, LIANG Yejin^1,3, JIANG Yujie⁴ 3true ［Abstract］　The incidence of metabolic diseases is on the rise, seriously affecting people′s physical health. Adipose tissue phenotype transformation is a key target for regulating metabolic diseases, promoting adipose tissue browning, significantly improving insulin resistance and energy imbalance, while adipose tissue whitening exacerbates inflammatory responses and accelerates disease progression. In this paper, the research progress in the mechanism of adipose tissue phenotype transformation and its role in metabolic diseases is reviewed.]]> 2026/1/31 11:24:05 1, DING Yabin¹, XIANG Xinxin²]]> WEI Xiaomei¹, DING Yabin¹, XIANG Xinxin² 2true ［Abstract］　Advanced thyroid cancer remains a clinical challenge due to the limited effectiveness of traditional treatments. Although molecular targeted therapy can prolong the progression-free survival of the patients, the problem of drug resistance limits its long-term effectiveness. The combination of immunotherapy with targeted therapy or radioiodine shows potential for synergy, but the overall efficacy still needs further optimization. In this paper, the research progress in precision medicine for advanced thyroid cancer is reviewed.]]> 2026/1/31 11:24:05 DENG Chao, WUFUER Yimaer 1true