［Abstract］　Objective　To investigate the association between interleukin-10( IL-10) polymorphism and the risk of coronary heart disease(CHD) in Guangxi Zhuang population. Methods　One thousand two hundred and two subjects were enrolled in this case-control study including 564 CHD cases(CHD group) and 638 controls(control group). Sequenom MassArray System was used to perform genotyping of IL-10 single nucleotide polymorphisms(SNPs), and enzyme linked immunosorbent assay(ELISA) was used to detect the level of plasma IL-10. Other biochemical parameters were tested by standard protocols in the lab of the People′s Hospital of Guangxi Zhuang Autonomous Region. Logistic regression model was used to evaluate the relationship between IL-10 polymorphism and the risk of CHD in Guangxi Zhuang population. Results　Compared with those in the controls, the associations between IL-10 polymorphisms including rs3021094, rs3790622, rs1800871 and the risk of CHD were not significant in Guangxi Zhuang population. After further adjustment for the risk factors, the results were not statistically significant. Meanwhile, the study did not find any significant differences in plasma IL-10 levels between those study genotypes. Conclusion　IL-10 polymorphisms of rs3021094, rs3790622 and rs1800871 might not be related to the risk of CHD in Guangxi Zhuang population.]]> 2019/5/31 17:17:32 YANG Zi-cong, SHI Ying, XUE Yan, et al. 6true ［Abstract］　Interleukin-37b(IL-37b) is a novel anti-inflammatory cytokine in the interleukin-1 ligand family. Accumulating evidence has demonstrated that both circulating and local IL-37b levels are increased in the patients with atherosclerotic disease and associated with an adverse outcome, and some experimental studies have showed that both exogenous IL-37b and endogenous IL-37b protect mice from atherosclerosis, which indicates that IL-37b may be a novel therapeutic target in prevention and treatment of atherosclerotic disease.]]> 2019/5/31 17:17:32 JI Qing-wei 5true ［Abstract］　Objective　To investigate the relationship between percutaneous coronary artery intervention(PCI) and cognitive impairment in acute myocardial infarction(AMI) patients. Methods　One hundred and fifty-five AMI patients were enrolled in this study, of whom 99 AMI cases were performed PCI(PCI group) and 56 AMI cases were not performed PCI(control group). Their cognitive function was evaluated by Telephone Interview for Cognitive Status-Modified(TICS-m), and biochemistry indexes were tested by standard procedures in the Lab of the People′s Hospital of Guangxi Zhuang Autonomous Region. All the subjects were followed up for 1 year, and their cognitive function was re-evaluated by TICS-m at the end of the follow-up. Results　There was no significant difference in TICS-m between the PCI group and the control group at baseline (P>0.05). The results indicated that the total scores of TICS-m in the control group were significantly lower than those in the PCI group［(31.07±1.74)points vs (32.56±2.21)points, P=0.000］, among which verbal and attention function scores in the control group were significantly lower than those in the PCI group［(13.16±1.43)points vs (14.49±1.64)points, P=0.000］, while there were no significant differences in memory and orientation scores(P>0.05) after 1-year follow up. As time went on, there were no significant differences in cognitive impairemnts among the patients with AMI in different positions in both of the two groups(P>0.05). Conclusion　The AMI patients not treated with PCI have more severe long-term cognitive impairment than those treated with PCI.]]> 2019/5/31 17:17:32 SHI Ying, LIU Hai-run, YANG Zi-cong, et al. 4true ［Abstract］　Thalassemia is a very important type of hereditary hemoglobinopathy in southern China and Southeast Asia. There are different conclusions about thalassemia and atherosclerotic diseases and their cardiovascular risks. There are controversial opinions about whether light thalassemia gene carrier is a contributor or a protective factor for cardiovascular risk and atherosclerosis. This paper summarizes these research views.]]> 2019/5/31 17:17:32 ZHONG You, WANG Fang 3true ［Abstract］　Resistant hypertension(RH) is a special type of hypertension, which is underscored by the associated risk of adverse outcomes compared with non-RH. Accurate diagnosis and treatment play an important role in control of blood pressure(BP) and prevention of cardiovascular events. Once antihypertensive medication adherence is confirmed and out-of-office BP recordings exclude a white-coat effect, evaluation includes identification of contributing lifestyle issues, detection of drugs interfering with antihypertensive medication effectiveness, screening for secondary hypertension, and assessment of target organ damage. Management of RH includes maximization of lifestyle interventions, use of long-acting thiazide-like diuretics and calcium channel blocker(CCB), addition of the renin-angiotensin system inhibitor(RASI) and a mineralocorticoid receptor antagonist according to the plasma renin level, and, if BP remains elevated, stepwise addition of antihypertensive drugs with complementary mechanisms of action is used to lower BP.]]> 2019/5/31 17:17:32 LI Shi-cheng, LIU Ling, YAN Xiao-wei 2true ［Abstract］　Cardiac resynchronization therapy(CRT) is an effective non-drug strategy for patients with chronice heart failure(CHF). It is highly recommended to treat CHF patients with NYHA class Ⅱ～Ⅳ, sinus rhythm and left bundle branch block. It can also be used in some non-left bundle branch block CHF patients. Althought CRT is effective in most patients, there are still some CHF patients who are not significantly improved by it(CRT nonresponders). How to reduce the proportion of CRT nonresponders is an inportant issue in the clinical application of CRT. In this review focus on the mechanisms of CRT, the results of CRT clinical trials, and the causes and solutions for CRT nonresponders.]]> 2019/5/31 17:17:32 ZHANG Hai-feng, WANG Jing-feng 1true