［Abstract］　Objective　To retrospectively analyze the clinicopathological characteristics and prognosis of papillary gastric adenocarcinoma(PGC). Methods　One hundred and thirty-eight cases of PGC were collected and followed up. SPSS23.00 software was used for analyzing the related clinicopathological data. Results　In age at surgery, tumor location, differentiation degree and other factors, the advantage PGC group showed generally similar features to those of papillary adenocarcinoma. The postoperative survival time of the advantage PGC group was significantly shorter than that of the non-advantage PGC group. Pathological types and pTNM stages were the independent factors of survival for the patients with PGC, and the advantage PGC group might be associated with death in the patients with PGC in a multifactorial survival analysis. Conclusion　PGC is considered to have a poor prognosis among gastric cancer types. Its clinicopathological characteristics and prognosis need to be studied in multiple cases and centers. More accurate and effective medical services should be provided for PGC patients according to their pathological types.]]> 2019/11/28 12:01:08 WANG Xin-yu, ZHAO Wei, GU Peng-fei, et al. 5true ［Abstract］　Objective　To observe the safety and efficacy of laparoscopic radical gastrectomy for gastric cancer under the guidance of enhanced recovery after surgery(ERAS). Methods　A retrospective controlled study was performed on 51 patients undergoing gastric cancer surgery from May 2018 to October 2018 in Department of Oncological Surgery, the First Hospital of Lanzhou University. The patients with gastric cancer were divided into two groups according to different treatment modes. Group A received traditional open laparotomy+ERAS mode(27 cases) and group B received laparoscopic surgery+ERAS mode(24 cases). The levels of preoperative white blood cell(WBC) count and D-dimer were detected and the operation time, the intraoperative blood loss, the lymph nodes dissected, the incision length, the first oral feeding time, the first anal exhaust time, the days of abdominal drainage tube placement, the postoperative hospitalization time, the hospitalization costs, and the incidence of complications and death were recorded. The levels of WBC count and D-dimer were checked respectively on the first day and the third day after operation. Results　The intraoperative blood loss, the skin incision length, the first oral feeding time, the first anal exhaust time and the days of abdominal drainage tube placement in the group B were better than those in the group A(P<0.05), but the operation time was longer(P<0.05) and the hospitalization costs were higher in the group B(P<0.05). There were no significant differences in the number of lymph nodes dissected, the postoperative hospital stay, the incidence of postoperative complications, and the levels of WBC and D-dimer on the first day before surgery, the first day after surgery and the third day after surgery(P>0.05). Conclusion　Compared with the traditional open surgery+ERAS mode, laparoscopic surgery+ERAS mode has the advantages of speeding up the recovery of postoperative intestinal function, shortening the number of days of abdominal drainage tube placement and reduce intraoperative bleeding. ERAS mode can be safely and effectively implemented in laparoscopic radical gastrectomy.]]> 2019/11/28 12:01:08 ZHANG Kai-guang, ZHOU Xiao-hai, HAO Jian-peng, et al. 4true ［Abstract］　Objective　To explore the key operation skills of laparoscopic natural orifice specimen extraction surgery(NOSES) for colorectal cancer by resection of the tumor inside the body and dragging-out removal per anus and rectum. Methods　The clinical data of the colorectal cancer patients receiving laparoscopic NOSES for resection of the tumors inside the body and dragging-out removal per anus and rectum from June 2017 to March 2019 in Sichuan Cancer Hospital and the intra-operative surgical skills were retrospectively analyzed and summarized. Results　All the 29 patients underwent successful surgery, with average operative time of (252.0±57.7)minutes, intraoperative bleeding volume of (44.6±20.8)milliliters, postoperative exhausting time of (20.7±9.2)hours, and hospital stay of (10.7±2.5)days. No abdominal contamination occurred during operation. All the patients recovered smoothly after operation, and no anastomotic leakage occurred. All of the patient were followed up until October 2019, none of them had tumor recurrence or metastasis. Conclusion　Laparoscopic NOSES is safe and feasible for treatment of colorectal cancer by means of resection of the tumor inside the body and dragging-out removal per anus and rectum. Observing the principles of asepsis and tumor-free strictly and mastering the key manipulation skills are the key points to guarantee the success of the operation.]]> 2019/11/28 12:01:08 LI Jie, ZHOU Ying, RUI Yuan-yi, et al. 3true ［Abstract］　Objective　To explore the application value of three classification criteria and nomogram in Chinese patients with gastrointestinal stromal tumors(GIST). Methods　(1)The clinical and follow-up data of 163 GIST patients who had complete pathology and follow-up data and received complete surgical resection in the People′s Hospital of Guangxi Zhuang Autonomous Region between January 2005 and July 2018 were collected and retrospectively analyzed. (2)163 cases of GIST were evaluated for risk assessment by Fletcher, Miettinen and NIH2008 modified version, the accuracy of Fletcher, Miettinen and NIH2008 classifications were compared. (3)The nomogram model was established and its application value was evaluated. Results　(1)For the criteria of Fletcher, Miettinen and NIH2008, the tumor-free survival time of the very low-risk group and the low-risk group were significantly longer than those of the intermediate-risk group and the high-risk group(P<0.05), but there was no significant difference in tumor-free survival time between the very low-risk group and the low-risk group(P>0.05) and there was no significant difference in tumor-free survival time between the intermediate-risk group and the high-risk group(P>0.05). (2)The ROC curves of NIH2008 modified version, Miettinen and Fletcher classifications on outcomes were established, and their the area under the curves(AUCs) were 0.757, 0.760 and 0.767, respectively. (3)The nomogram model was established using R language. The alignment pattern was close to a straight line with slope 1, and AUC of the nomogram was 0.768(95%CI: 0.696～0.831). Conclusion　The three classification criteria of Fletcher, Miettinen and NIH2008 modified version can effectively assess the recurrence risk of GIST patients after surgery. Fletcher is convenient, but may misjudge the risk of recurrence of GIST in different parts. NIH2008 modified version has high accuracy and convenient operation. The nomogram can accurately and individually predict the postoperative recurrence risk of GIST for GIST patients, but has complicated operation.]]> 2019/11/28 12:01:08 ZHANG Dao-tong, LI Ze-lun, HUANG Liang, et al. 2true ［Abstract］　Colorectal cancer(CRC) is the most common malignant tumor of digestive tract in China and seriously endangers people′s health and quality of life. The occurrence and development of CRC is a multi-factor and multi-step process. microRNA(miRNA) is an endogenous, non-coding single stranded small RNA, and plays an important role in cell proliferation, differentiation, apoptosis, and tumorigenesis and development. At present, several miRNAs are found to play important role in CRC progress. In this paper, we review the role of miRNAs in CRC metastasis.]]> 2019/11/28 12:01:08 LAI Hao, ZHANG Jie, ZUO Hong-qun, et al. 1true