［Abstract］　The treatment of hepatocellular carcinoma(HCC) has always been the focus of many scholars. Despite the development of new therapies, HCC remains a “difficult to treat” cancer because HCC typically occurs in advanced liver disease or hepatic cirrhosis. In terms of treatment, although surgical resection and liver transplantation are radical treatments, the two treatments are not suitable for most patients due to the complexity of transplant-related problems and the occult nature of HCC. In recent years, with the improvement of equipment and technology, more and more attention has been paid to the minimally invasive interventional treatment of HCC, of which transarterial chemoembolization(TACE) and tissue ablation(TA) are the most widely used.In this paper, we mainly discuss the effectiveness and feasibility of the combination of the two kinds of interventional therapy in the treatment of HCC, as well as the research progress of interventional therapy in the field of HCC in recent years.]]> 2020/4/10 18:04:33 LYU Tian-shi, ZOU Ying-hua 6true ［Abstract］　Hepatocellular carcinoma(HCC) is a primary malignant tumor of the liver, accounting for 85%～90% of primary liver cancer. With the continuous development of next-generation sequencing(NGS) technology, understanding molecular types and regulatory mechanisms of different signaling pathways, and molecular targeted therapy and immunotherapy for the target have become research hotspots in the field of HCC. This review summarizes the research status, the main genetic alterations and signaling pathways in the pathogenesis of HCC, providing novel ideas for the accurate clinical management and research of HCC.]]> 2020/4/10 18:04:33 CHEN Ting-ting, LI Jia-ping 5true ［Abstract］　The lungs have a dual blood supplies constituted by bronchial artery, pulmonary artery and pulmonary vein. The high-pressure bronchial artery and pulmonary vein consists the systemic circulation and the low-pressure pulmonary artery and pulmonary vein consists the pulmonary arterial circulation. Arteriovenous malformations of systemic high-pressure arteries include bronchial artery-pulmonary vein malformations and bronchial-pulmonary artery malformations. The feeding arteries, malformed vascular masses and drainage veins of arteriovenous malformations are easy to form aneurysms. Massive hemoptysis can be caused by ruptured pulmonary artery aneurysm. Pulmonary artery aneurysm is rare and easy to be missed in diagnosis. The blood supply of pulmonary artery aneurysm can origin from pulmonary circulation or systemic circulation alone, and can also involve pulmonary circulation and systemic circulation at the same time. It is difficult to control the ruptured pulmonary artery aneurysm with massive hemoptysis by systemic arterial embolization alone. Therefore, attention should be paid to the diagnosis and interventional treatment of pulmonary artery aneurysms in patients with massive hemoptysis.]]> 2020/4/10 18:04:33 LI Ya-hua, LI Jing, HAN Xin-wei 4true ［Abstract］　With the continuous innovation of endovascular treatment equipment, endovascular treatment has gradually become the main treatment mode for arterial stenosis and occlusion diseases of lower limbs. Due to the biomechanical characteristics of the femoral-popliteal artery in its special parts, the long-term patency rate is still unsatisfactory even for the latest generation of nickel-titanium alloy stents. In view of the role of drug coating technology in inhibiting intimal hyperplasia of lower limb arteries, drug-carrying devices have gradually become recommendations for high-level clinical applications, especially suitable for long-segment lesions of femoral-popliteal artery, calcified lesions, restenosis lesions and infrapatellar lesions. Moreover, ideal vascular preparation includes reasonable application of volume reduction measures and optimization of balloon dilation mode, which can further avoid vascular restenosis after balloon dilation or stent implantation or reduce the re-intervention rate. Therefore, endovascular treatment of lower extremity artery should be standardized,and the indications should be strictly controlled, and curative effect should be effectively improved in practice and innovation.]]> 2020/4/10 18:04:33 CUI Jin-guo, LIU Jing-lei 3true ［Abstract］　Objective　To explore the clinical application of ultrasound-guided antegrade venipuncture combined with AngioJet thrombus suction catheter and iliac vein stent implantation in one-stop treatment of thrombotic iliac vein compression syndrome. Methods　A retrospective analysis was made on 16 patients with thrombotic iliac vein compression syndrome admitted to our department from June 2018 to January 2020. Under the protection of inferior vena cava filter, ultrasound-guided anterograde venipuncture of popliteal vein or saphenous vein of left lower extremity was used to establish a pathway. After AngioJet thrombectomy, thrombolytic catheter was inserted, and iliac vein stent was implanted in Phase Ⅰ or Phase Ⅱ. Results　Among the 16 patients with thrombotic iliac vein compression syndrome, 11 patients received left popliteal vein puncture, and 5 patients received left small saphenous vein puncture. The puncture success rate and the technical success rate were 100.00%. The average suction volume was (178.20±14.20)ml, and the urokinase dosage was (150.59±60.92)million U. 7 patients were implanted with iliac vein stents in Phase Ⅰ, and 9 patients were implanted with iliac vein stents after thrombolysis. 13 patients were in grade Ⅲ thrombus clearance rate, and 3 patients in grade Ⅱ thrombus clearance rate. No serious complications such as fatal bleeding and symptomatic pulmonary embolism occurred. Conclusion　Ultrasound-guided anterograde left lower extremity venipuncture combined with AngioJet thrombus suction catheter and iliac vein stent can provide a one-stop solution for patients with thrombotic iliac vein compression syndrome, simplify the operation process and improve the success rate of the operation, and can improve the long-term effect and reduce the incidence of long-term post-thrombotic syndrome.]]> 2020/4/10 18:04:33 YIN Shi-wu, PAN Sheng-quan, XIANG Ting-miao, et al. 2true ［Abstract］　Objective　To investigate the clinical efficacy of arterial embolectomy assisted with intraoperative digital subtraction angiography(DSA) in treatment of acute limb ischemia(ALI). Methods　The clinical data of 74 patients(a total of 79 affected limbs) undergoing arterial embolectomy assisted with intraoperative DSA between September 2012 and June 2019 were collected, and the patients′ limb salvage rate, surgical procedures, recanalization ratio of inferior genicular artery, complications and following-up results were retrospectively analyzed to evaluate the surgical effects. Results　The operations were successfully completed on all the 74 patients with ALI, and no operation-related complications occurred during the operations. Sixty-one cases(64 affected limbs in total) succeeded in limb salvage, with a limb salvage rate of 81.01%(64/79). Among the 59 patients undergoing lower limb surgery, the total anterior tibial artery recanalization rate was 83.05%(49/59), and the total posterior tibial artery recanalization rate was 72.88%(43/59), and the total peroneal artery recanalization rate was 84.75%(50/59). There were no postoperative complications leading to death in 61 patients with effective follow-ups. Conclusion　Arterial embolectomy assisted with intraoperative DSA in treatment of ALI can improve the success rate of limb salvage and reduce the incidence of complications related to the operation.]]> 2020/4/10 18:04:33 NONG Jian-wen, WANG Chun-ming, WEI Yan-hua, et al. 1true