［Abstract］　Artificial intelligence has gradually penetrated into the studies of genomics, transcriptomics, radiomics and pathomics of renal cancer, and has made important achievements and preliminary applications in the field of diagnosis and treatment of renal cancer. However, current studies mainly focus on the diagnosis of renal cancer and simple clinical prognosis prediction, and lack the prediction of the efficacy of targeted therapy for renal cancer and multi-center clinical validation. In the future, large-scale, multi-center studies are still needed to further verify the application value of artificial intelligence in the field of diagnosis and treatment for renal cancer. This paper reviews the application and prospect of artificial intelligence in diagnosis and treatment of renal cancer.]]> 2021/8/6 11:16:11 CHEN Si-teng, ZHENG Jun-hua 5true ［Abstract］　At present, systemic treatment is the main treatment for oligonucleotide metastatic prostate cancer, and there is a lack of high-level research evidence for local treatment of primary focus of metastatic prostate cancer. Some scholars put forward the concept of oligonucleotide metastatic prostate cancer for patients with small metastatic load, believing that prostate cancer patients with metastatic foci less than 5 have a relatively good prognosis. However, the criteria of oligosaccharide transfer included in various studies are not uniform. According to previous database retrospective studies, radiotherapy for primary focus of metastatic prostate cancer or surgery can improve the overall prognosis of prostate cancer patients with small metastatic load, but there is still a lack of large-sample randomized controlled studies to confirm its effectiveness. This paper reviews the existing studies on local treatment of oligonucleotide metastatic prostate cancer and evaluates the feasibility and effectiveness of local treatment of primary focus of oligonucleotide metastatic prostate cancer.]]> 2021/8/6 11:16:11 HOU Hui-min, LIU Ming 4true ［Abstract］　The repair and reconstruction of ureteral stricture, especially the repair and reconstruction of upper and middle ureteral stricture, has always been a major difficulty in urological surgery. If end-to-end ureteral anastomosis is not possible, the only options in the past are ileal ureter replacement and renal autotransplantation, causing great surgical trauma. The application of oral mucosa greatly reduces the trauma in the repair and reconstruction of upper and middle ureteral stricture, bringing a new option to those patients with upper and middle ureteral stricture. This paper summarizes the application of oral mucosa(buccal mucosa/lingual mucosa) in the repair and reconstruction of ureteral stricture.]]> 2021/8/6 11:16:11 CHAI Shuai-shuai, LI Bing 3true ［Abstract］　Objective　To investigate the clinicopathological characteristics, types of mutation and treatment methods of cell cycle-dependent kinase 12(CDK12)-mutant prostate cancer(PCa). Methods　The clinicopathological characteristics, gene mutation results and follow-up data of 10 patients with CDK12-mutant PCa were reported, and the related literature was reviewed and discussed. Results　The mean age of the 10 patients with a definite diagnosis was (66.60±6.80)years, and their mean serum prostate-specific antigen was 652.19 ng/ml, and their Gleason scores of puncture were more than or equal to 8 points. Of the 10 patients, eight had distant metastasis at the time of diagnosis. In addition, CDK 12 mutation occurred in castration-resistant stage in 6 patients. Conclusion　Patients with CDK12-mutant PCa, which has a high degree of malignancy and is prone to castration-resistant stage, may benefit from platinum-based chemotherapy, poly ADP-ribose polymerase(PARP) inhibitors or immunotherapy.]]> 2021/8/6 11:16:11 FAN Jun-jie, JIANG Fan, HE Da-lin, et al. 2true ［Abstract］　Objective　To evaluate the effects of two biopsy strategies, 6-core biopsy and 12-core biopsy, according to prostate-specific antigen(PSA) related parameters, and to provide appropriate individualized biopsy strategies for the patients. Methods　The data of 525 patients who underwent prostate needle biopsy in the People′s Hospital of Guangxi Zhuang Autonomous Region from March 2013 to November 2019 due to suspected prostate cancer were analyzed retrospectively. The total cancer detection rate(CDR) and the high-grade cancer detection rate(HGCDR) were compared between the two different strategies of prostate needle biopsy. Results　A total of 525 patients among whom 170 patients were diagnosed with prostate cancer were enrolled in this study, including 331 cases with serum total PSA(tPSA)<20 ng/ml. When tPSA<20 ng/ml and prostate volume(PV)≤60 ml, the CDR of 12-core biopsy was higher than that of 6-core biopsy. When tPSA<20 ng/ml and prostate-specific antigen density(PSAD)≥0.15 ng/(ml·cc), the CDR of 12-core biopsy was also higher than that of 6-core biopsy. The 12-core biopsy could help to find more high-grade cancers in patients with tPSA<20 ng/ml and negative transrectal ultrasound(TRUS). In addition, the HGCDR of the 12-core biopsy was higher in patients with tPSA<20 ng/ml and PV≤60 ml. Conclusion　For patients with tPSA<20 ng/ml, 12-core biopsy is recommended when PV≤60 ml and PSAD≥0.15 ng/(ml·cc) or in combination with the normal TURS results.]]> 2021/8/6 11:16:11 HUANG Gui-hai, LI Zuan, NONG De-yong, et al. 1true