［Abstract］　Statins are the cornerstone of drug treatment of dyslipidemia and play an important role in the prevention and control of atherosclerotic cardiovascular disease(ASCVD) globally. However, statins often induce muscle toxicity in clinic, ranging from mild myalgia to rare severe rhabdomyolysis, which leads to the reduction of patients′ compliance and increases the medical burden of cardiovascular diseases. The hot spot and the focus of the clinical discussion are how to maximize the lipid-lowering effect of statins and reduce the occurrence of myotoxic adverse effects. The mechanisms of myotoxicity induced by statins may include two aspects: the pharmacokinetic conditions resulting in statins accumulation in the myocytes and the myocyte conditions favouring statin-induced myotoxicity. The risk factors of statin-induced myotoxicity can be classified into non-genetic factors and genetic factors. Non-genetic factors include advanced age, low body mass index, multisystem diseases, etc. Genetic factors include SLCO1B1, ABCG2, ABCB1 gene polymorphisms that affect statins exposure, among which SLCO1B1 gene polymorphism has the most significant effect.Therefore, the introduction of gene detection into clinical practice, combined with other risk factors, can better avoid adverse reactions and use statins reasonably.]]> 2021/11/2 15:11:32 CHEN Yan, LI Qing 5true ［Abstract］　Flavonoids widely exist in plants such as Chinese herbal medicine, fruits and vegetables, which have many biological effects. They play important roles in the improvement, prevention and treatment of many metabolic diseases such as obesity, diabetes and cancer.Flavonoid glycosides natural products are the main existing forms of flavonoids in plants. The common glycosyl ligands are glucose, rhamnose, neohesperidin and rutin. Therefore, the number of glycosyls and their linked positions determine the absorption, distribution, metabolism and biological activity of flavonoid glycosides in vivo. At the same time, flavonoids interact with intestinal microorganisms after entering the body, which directly affects their metabolism and biological activity. This review focuses on the in vivo absorption, interaction with gut microbiota and biological activity of glycosylated flavonoids and their application in clinical diseases.]]> 2021/11/2 15:11:32 WU Fang, CHEN Gui, CAO Zheng, et al. 4true ［Abstract］　Glycosphingolipids, as amphiphilic glycolipids on the surface of cell membranes of living organisms, have important biological functions such as maintaining plasma membrane stability, mediating cell recognition and adhesion, regulating signal transduction and so on. Specific glycosphingolipids have been found to be abnormally expressed in many tumor diseases and participate in related molecular mechanisms. They are closely related to the development of diseases and are widely studied as diagnostic markers of tumor diseases and important targets of immunotherapy.In this paper, the research progress in the correlation between different kinds of glycoshingolipids and tumor diseases is reviewed.]]> 2021/11/2 15:11:32 JIN Xue-feng, YANG Guang-yu 3true ［Abstract］　Objective　To investigate the role of nutrition support pharmacists(NSPs) in the comprehensive management of nutritional therapy for critically ill patients. Methods　Through the practice of NSPs on pharmaceutical care and intervention for 4 critically ill patients, this paper indentified how pharmacists balanced the benefits and risks of nutritional therapy for the critically ill patients with complicated problems, and then optimized the nutritional therapeutic regimen. Results　NSPs with abundant medical and nutritional knowledge and proficiency in the individualized use of nutritional medicines were able to optimize nutritional medication regimens to improve the prognosis of critically ill patients based on the specific situation of the patients. Conclusion　NSPs participating in the process of nutrition support for critically ill patients with complicated problems can improve the safety and effectiveness of nutritional pharmacotherapy, which reflects the core value and unique role of clinical pharmacy.]]> 2021/11/2 15:11:32 ZHOU Xin, LI Juan, YAO Gao-qiong, et al. 2true ［Abstract］　Objective　To analyze the situation of clinical pharmacists participating in the pharmaceutical consultations of anti-infection in Department of Urology, and to provide experience for the treatment and prevention of other infectious diseases. Methods　A total of 144 clinical pharmaceutical consultations of 105 urological patients participated by clinical pharmacists from January 2018 to December 2020 were retrospectively analyzed. The type of consultations, the distribution of infection foci, the formulation and adjustment of anti-infection schemes, the clinical adoption and effect evaluation were counted to evaluate the therapeutic effect of clinical pharmacists participating in the consultation of urinary tract infection. Results　Among the 144 consultations, clinical pharmacists made and adjusted anti-infection schemes in 33 cases(22.92%), and special-class antimicrobial agents approval in 87 cases(60.42%). The guidance on use of anti-infective drugs was completed in 24 cases(16.67%). The clinical adoption rate of clinical pharmaceutical consultations was 95.83%, and the effective rate was 97.83%. Conclusion　The participation of clinical pharmacists in urological anti-infective treatment consultations can explore the rationality of the use of anti-bacterial drugs in urological surgery from the perspective of pharmacy, and improve the effectiveness of anti-infective treatment.]]> 2021/11/2 15:11:32 LIU Xiao-xia, ZHANG Li, YE Xi, et al. 1true