［Abstract］　Objective　To analyse the clinical and pathological features between the patients with mass enhanced breast cancer and those with non-mass enhanced breast cancer. Methods　Seventy-six patients with invasive breast cancer admitted to the First Medical Center of the Chinese People′s Liberation Army(PLA) General Hospital from January 2019 to December 2019 were retrospectively collected. According to the results of breast dynamic contrast-enhanced magnetic resonance imaging(MRI), the patients were divided into mass enhancement group(57 cases) and non-mass enhancement group(19 cases). The clinical and pathological features were compared between the two groups. Results　Compared with those in the mass enhancement group, the apparent diffusion coefficient(ADC) value of the lesions in the non-mass enhancement group was increased ［(0.95±0.19) vs (0.85±0.17), P=0.034］, and the clear rate of lesion boundary in the non-mass enhancement group was decreased(15.79% vs 63.16%, P=0.000). The expression rate of human epidermal growth factor receptor-2(HER-2) negative in the non-mass enhancement group was significantly lower than that in the mass enhancement group(0.00% vs 26.32%, P=0.013). There were no significant differences in MRI early enhancement rate, enhancement platform, lesion size, estrogen receptor(ER), progesterone receptor(PR), proliferating cell nuclear antigen(Ki-67), metastasis rate, number of metastatic axillary lymph nodes supraclavicular lymph node metastasis rate, invasion rate of skin or chest wall, pathological type and lymphocyte infiltration rate between the patients in the two groups(P>0.05). Conclusion　The expression rate of HER-2 negative in the invasive breast cancer patients with non-mass enhancement is lower, and the ADC value of the lesions is higher, and the probability of unclear tumor boundary is higher, which may be related to the poor prognosis of the patients.]]> 2022/11/30 11:57:24 WU Xiang-dong, TIAN Lin, HAO Xiao-peng 6true ［Abstract］　Chinese Society of Clinical Oncology(CSCO) Guidelines for the Diagnosis and Treatment of Breast Cancer have greatly promoted the standardized diagnosis and treatment of breast cancer in China since they were issued in 2017 due to their scientificity, practicality and timeliness. The guidelines were updated again in April 2022 to better meet clinical needs. The key points of the updated guidelines on adjuvant therapy for breast cancer mainly focus on adjuvant therapy after neoadjuvant therapy and adjuvant therapy intensification strategy. On the basis of classified therapy, it further reflects stratified therapy and the influence of neoadjuvant therapy on postoperative adjuvant therapy, and enriches the content of adjuvant therapy after neoadjuvant therapy and the intensification therapy after adjuvant therapy. Based on the 2022 CSCO Guidelines for the Diagnosis and Treatment of Breast Cancer, this paper interprets the updated key points of adjuvant therapy for breast cancer.]]> 2022/11/30 11:57:24 WU Xue-xue, ZHOU Jin-mei, WANG Tao 5true ［Abstract］　Objective　To study the correlation between serum level of interleukin-6(IL-6) and neuropathic pain caused by the treatment of taxanes in breast cancer patients. Methods　The clinical data of 24 breast cancer patients who were treated with taxanes in the Affiliated Hospital of Inner Mongolia Medical University from January 2021 to September 2022 were retrospectively analyzed. The level of IL-6 in the serum was detected before chemotherapy, and the degree of neuropathic pain after 4 cycles of chemotherapy was evaluated by Visual Analogue Scale(VAS) score. According to the degrees of drug-induced neuropathic pain, the patients were divided into group A(no pain, 9 cases), group B(mild pain, 6 cases), group C(moderate pain, 5 cases) and group D(severe pain, 4 cases). The level of IL-6 in the serum before chemotherapy was compared among all groups, and the correlation between the IL-6 level and the VAS scores was analyzed. Receiver operating characteristic(ROC) curve was drawn to analyze the predictive value of IL-6 in the serum for neuropathic pain. Results　After 4 cycles of follow-up, 15 patients developed neuropathic pain. There was a significant difference in the level of IL-6 among the four groups before treatment(P<0.01). The patients with higher IL-6 level than the normal IL-6 level before treatment were more likely to develop neuralgia(P<0.05). The level of IL-6 in the patients with pain was positively correlated with the VAS scores(r=0.855, P<0.01). The results of ROC curve analysis showed that the serum level of IL-6 before treatment could predict the neuropathic pain caused by the treatment of taxanes for breast cancer［area under the curve(AUC)=0.881, P=0.002］. Conclusion　The serum level of IL-6 in patients before chemotherapy is positively correlated with the degree of chemotherapy-induced neuralgia. The serum level of IL-6 before chemotherapy can be used as a serological indicator to predict the neuropathic pain caused by the treatment of taxanes for breast cancer.]]> 2022/11/30 11:57:24 LIU Shu-juan, LIU Meng-ying, CHEN Yi-tao, et al. 4true ［Abstract］　Breast cancer is a highly heterogeneous disease, and metastatic breast cancer is the type with the worst prognosis. At present, the standard treatment of metastatic breast cancer is still systemic treatment. Clinically, accordingto the disease progression of patients, individualized treatment plans are formulated to improve the quality of life of the patients. Liquid biopsy is a process in which body fluids are sampled and analyzed, allowing continuous monitoring of multiple tumor indicators. This paper reviews the recent advances in application of liquid biopsy in diagnosis and treatment of metastatic breast cancer.]]> 2022/11/30 11:57:24 ZHU Ling-xiao, XIAO Chun, ZHANG Jian-hua 3true ［Abstract］　Objective　To analyze the causes of infusion port catheter inserted through the right internal jugular vein into the heterotopic ipsilateral subclavian vein by mistake in patients with infusion ports implanted in their chest walls. Methods　From August 2017 to August 2022, 206 cases of infusion port implantation via internal jugular vein approach in the Department of Breast and Thyroid Surgery of Tongliao City Hospital were reviewed, including 2 cases of ectopic catheter tip to ipsilateral subclavian vein. The causes of the occurrence and corresponding management strategies were analyzed. Results　The main causes of catheter ectopic placement were different placement paths of catheters in infusion ports, operation skills of the operators and body positions of the patients. Conclusion　The routine vascular examination before operation, fine operation during the surgery, patients′ body position coordination, puncture site selected, orientation of needle tip slope, and the patients′ feelings during the surgery are all methods to avoid ectopic puncture catheter.]]> 2022/11/30 11:57:24 ZHANG Jia-rui, LI Yan-xin 2true ［Abstract］　Breast cancer is the most common malignant tumor in women. At present, surgical resection is the main comprehensive treatment of breast cancer. For a variety of postoperative complications of breast cancer after surgery, early rehabilitation is needed. This paper reviews the advances in postoperative rehabilitation therapy for breast cancer patients.]]> 2022/11/30 11:57:24 QIN Lan-hui, CHEN Qi-bo, WANG Shuang-quan, et al. 1true